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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NR4A2-GPD2 (FusionGDB2 ID:60177)

Fusion Gene Summary for NR4A2-GPD2

Fusion gene summary

Fusion gene information	Fusion gene name: NR4A2-GPD2
	Fusion gene ID: 60177
		Hgene	Tgene
	Gene symbol	NR4A2	GPD2
	Gene ID	4929	2820
	Gene name	nuclear receptor subfamily 4 group A member 2	glycerol-3-phosphate dehydrogenase 2
	Synonyms	HZF-3\|NOT\|NURR1\|RNR1\|TINUR	GDH2\|GPDM\|mGPDH
	Cytomap	2q24.1	2q24.1
	Type of gene	protein-coding	protein-coding
	Description	nuclear receptor subfamily 4 group A member 2NGFI-B/nur77 beta-type transcription factor homologT-cell nuclear receptor NOTimmediate-early response protein NOTintermediate-early receptor proteinnuclear receptor related 1nur related protein-1, human	glycerol-3-phosphate dehydrogenase, mitochondrialGPD-MGPDH-Mglycerol-3-phosphate dehydrogenase 2 (mitochondrial)mitochondrial glycerophosphate dehydrogenasemtGPDtesticular tissue protein Li 76
	Modification date	20200313	20200313
	UniProtAcc	P43354	P43304
	Ensembl transtripts involved in fusion gene	ENST00000539077, ENST00000339562, ENST00000409108, ENST00000409572, ENST00000426264, ENST00000429376,	ENST00000310454, ENST00000409125, ENST00000409674, ENST00000438166, ENST00000540309, ENST00000496190,
Fusion gene scores	* DoF score	3 X 5 X 2=30	4 X 4 X 3=48
	# samples	4	5
	** MAII score	log2(4/30*10)=0.415037499278844 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: NR4A2 [Title/Abstract] AND GPD2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GPD2(157332719)-NR4A2(157182840), # samples:3 NR4A2(157187180)-GPD2(157332610), # samples:3
Anticipated loss of major functional domain due to fusion event.	GPD2-NR4A2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. GPD2-NR4A2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. GPD2-NR4A2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NR4A2	GO:0006351	transcription, DNA-templated	17184956
Hgene	NR4A2	GO:0031668	cellular response to extracellular stimulus	7877627

Fusion gene breakpoints across NR4A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GPD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-HD-A634-01A	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
ChimerDB4	HNSC	TCGA-HD-A634	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
ChimerDB4	HNSC	TCGA-HD-A634	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
ChimerDB4	HNSC	TCGA-HD-A634	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+

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Fusion Gene ORF analysis for NR4A2-GPD2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000539077	ENST00000310454	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
5CDS-5UTR	ENST00000539077	ENST00000409125	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
5CDS-5UTR	ENST00000539077	ENST00000409674	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
5CDS-5UTR	ENST00000539077	ENST00000438166	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
5CDS-5UTR	ENST00000539077	ENST00000540309	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
5CDS-intron	ENST00000539077	ENST00000496190	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000339562	ENST00000310454	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000339562	ENST00000310454	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-5UTR	ENST00000339562	ENST00000310454	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000339562	ENST00000409125	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000339562	ENST00000409125	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-5UTR	ENST00000339562	ENST00000409125	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000339562	ENST00000409674	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000339562	ENST00000409674	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-5UTR	ENST00000339562	ENST00000409674	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000339562	ENST00000438166	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000339562	ENST00000438166	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-5UTR	ENST00000339562	ENST00000438166	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000339562	ENST00000540309	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000339562	ENST00000540309	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-5UTR	ENST00000339562	ENST00000540309	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000409108	ENST00000310454	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000409108	ENST00000310454	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-5UTR	ENST00000409108	ENST00000409125	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000409108	ENST00000409125	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-5UTR	ENST00000409108	ENST00000409674	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000409108	ENST00000409674	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-5UTR	ENST00000409108	ENST00000438166	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000409108	ENST00000438166	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-5UTR	ENST00000409108	ENST00000540309	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000409108	ENST00000540309	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-5UTR	ENST00000409572	ENST00000310454	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000409572	ENST00000310454	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-5UTR	ENST00000409572	ENST00000409125	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000409572	ENST00000409125	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-5UTR	ENST00000409572	ENST00000409674	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000409572	ENST00000409674	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-5UTR	ENST00000409572	ENST00000438166	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000409572	ENST00000438166	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-5UTR	ENST00000409572	ENST00000540309	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000409572	ENST00000540309	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-5UTR	ENST00000426264	ENST00000310454	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000426264	ENST00000310454	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-5UTR	ENST00000426264	ENST00000310454	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000426264	ENST00000409125	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000426264	ENST00000409125	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-5UTR	ENST00000426264	ENST00000409125	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000426264	ENST00000409674	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000426264	ENST00000409674	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-5UTR	ENST00000426264	ENST00000409674	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000426264	ENST00000438166	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000426264	ENST00000438166	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-5UTR	ENST00000426264	ENST00000438166	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000426264	ENST00000540309	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000426264	ENST00000540309	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-5UTR	ENST00000426264	ENST00000540309	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000429376	ENST00000310454	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000429376	ENST00000310454	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-5UTR	ENST00000429376	ENST00000409125	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000429376	ENST00000409125	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-5UTR	ENST00000429376	ENST00000409674	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000429376	ENST00000409674	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-5UTR	ENST00000429376	ENST00000438166	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000429376	ENST00000438166	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-5UTR	ENST00000429376	ENST00000540309	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-5UTR	ENST00000429376	ENST00000540309	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-intron	ENST00000339562	ENST00000496190	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-intron	ENST00000339562	ENST00000496190	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-intron	ENST00000339562	ENST00000496190	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
5UTR-intron	ENST00000409108	ENST00000496190	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-intron	ENST00000409108	ENST00000496190	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-intron	ENST00000409572	ENST00000496190	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-intron	ENST00000409572	ENST00000496190	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-intron	ENST00000426264	ENST00000496190	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-intron	ENST00000426264	ENST00000496190	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
5UTR-intron	ENST00000426264	ENST00000496190	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
5UTR-intron	ENST00000429376	ENST00000496190	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
5UTR-intron	ENST00000429376	ENST00000496190	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
intron-5UTR	ENST00000409108	ENST00000310454	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
intron-5UTR	ENST00000409108	ENST00000409125	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
intron-5UTR	ENST00000409108	ENST00000409674	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
intron-5UTR	ENST00000409108	ENST00000438166	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
intron-5UTR	ENST00000409108	ENST00000540309	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
intron-5UTR	ENST00000409572	ENST00000310454	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
intron-5UTR	ENST00000409572	ENST00000409125	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
intron-5UTR	ENST00000409572	ENST00000409674	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
intron-5UTR	ENST00000409572	ENST00000438166	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
intron-5UTR	ENST00000409572	ENST00000540309	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
intron-5UTR	ENST00000429376	ENST00000310454	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
intron-5UTR	ENST00000429376	ENST00000409125	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
intron-5UTR	ENST00000429376	ENST00000409674	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
intron-5UTR	ENST00000429376	ENST00000438166	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
intron-5UTR	ENST00000429376	ENST00000540309	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
intron-5UTR	ENST00000539077	ENST00000310454	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
intron-5UTR	ENST00000539077	ENST00000310454	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
intron-5UTR	ENST00000539077	ENST00000409125	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
intron-5UTR	ENST00000539077	ENST00000409125	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
intron-5UTR	ENST00000539077	ENST00000409674	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
intron-5UTR	ENST00000539077	ENST00000409674	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
intron-5UTR	ENST00000539077	ENST00000438166	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
intron-5UTR	ENST00000539077	ENST00000438166	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
intron-5UTR	ENST00000539077	ENST00000540309	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
intron-5UTR	ENST00000539077	ENST00000540309	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+
intron-intron	ENST00000409108	ENST00000496190	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
intron-intron	ENST00000409572	ENST00000496190	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
intron-intron	ENST00000429376	ENST00000496190	NR4A2	chr2	157188992	-	GPD2	chr2	157332610	+
intron-intron	ENST00000539077	ENST00000496190	NR4A2	chr2	157187180	-	GPD2	chr2	157332610	+
intron-intron	ENST00000539077	ENST00000496190	NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for NR4A2-GPD2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+	0.02179659	0.9782034
NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+	0.02179659	0.9782034
NR4A2	chr2	157188991	-	GPD2	chr2	157332609	+	7.16E-06	0.99999285
NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+	0.02179659	0.9782034
NR4A2	chr2	157187179	-	GPD2	chr2	157332609	+	0.02179659	0.9782034
NR4A2	chr2	157188991	-	GPD2	chr2	157332609	+	7.16E-06	0.99999285

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NR4A2-GPD2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:157332719/:157182840)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NR4A2 P43354	GPD2 P43304
FUNCTION: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). {ECO:0000250, ECO:0000269\|PubMed:17184956}.	FUNCTION: Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device. {ECO:0000269\|PubMed:9070847}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for NR4A2-GPD2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NR4A2-GPD2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for NR4A2-GPD2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for NR4A2-GPD2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source