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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGAP24-MAPK10 (FusionGDB2 ID:6018)

Fusion Gene Summary for ARHGAP24-MAPK10

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP24-MAPK10
Fusion gene ID: 6018
HgeneTgene
Gene symbol

ARHGAP24

MAPK10

Gene ID

83478

5602

Gene nameRho GTPase activating protein 24mitogen-activated protein kinase 10
SynonymsFILGAP|RC-GAP72|RCGAP72|p73|p73RhoGAPJNK3|JNK3A|PRKM10|SAPK1b|p493F12|p54bSAPK
Cytomap

4q21.23-q21.3

4q21.3

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 24RAC1- and CDC42-specific GTPase-activating protein of 72 kDafilamin-A-associated RhoGAPrhoGAP of 73 kDasarcoma antigen NY-SAR-88mitogen-activated protein kinase 10JNK3 alpha protein kinaseMAP kinase 10MAP kinase p49 3F12c-Jun N-terminal kinase 3stress activated protein kinase betastress-activated protein kinase 1bstress-activated protein kinase JNK3
Modification date2020031320200313
UniProtAcc

Q8N264

P53779

Ensembl transtripts involved in fusion geneENST00000264343, ENST00000395183, 
ENST00000395184, ENST00000503995, 
ENST00000506421, 		ENST00000395157, 
ENST00000395160, ENST00000513839, 
ENST00000359221, ENST00000361569, 
ENST00000395161, ENST00000395166, 
ENST00000395169, ENST00000449047, 
Fusion gene scores* DoF score11 X 10 X 6=6609 X 9 X 7=567
# samples 1413
** MAII scorelog2(14/660*10)=-2.23703919730085
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/567*10)=-2.12483711191377
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP24 [Title/Abstract] AND MAPK10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP24(86700118)-MAPK10(87115560), # samples:2
ARHGAP24(86863426)-MAPK10(86938523), # samples:2
ARHGAP24(86863426)-MAPK10(86938528), # samples:2
MAPK10(87275683)-ARHGAP24(86893189), # samples:2
Anticipated loss of major functional domain due to fusion event.ARHGAP24-MAPK10 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ARHGAP24-MAPK10 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
ARHGAP24-MAPK10 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARHGAP24 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAPK10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-KK-A6E0-01AARHGAP24chr4

86700118

-MAPK10chr4

87115560

-
ChimerDB4PRADTCGA-KK-A6E0-01AARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
ChimerDB4SARCTCGA-DX-A8BM-01AARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
ChimerDB4SARCTCGA-DX-A8BM-01AARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
ChimerDB4SARCTCGA-SI-AA8C-01AARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
ChimerDB4SARCTCGA-SI-AA8C-01AARHGAP24chr4

86863426

-MAPK10chr4

86938528

-


Top

Fusion Gene ORF analysis for ARHGAP24-MAPK10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000264343ENST00000395157ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
5CDS-intronENST00000264343ENST00000395157ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
5CDS-intronENST00000264343ENST00000395160ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
5CDS-intronENST00000264343ENST00000395160ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
5CDS-intronENST00000264343ENST00000513839ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
5CDS-intronENST00000264343ENST00000513839ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
5CDS-intronENST00000395183ENST00000395157ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
5CDS-intronENST00000395183ENST00000395157ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
5CDS-intronENST00000395183ENST00000395160ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
5CDS-intronENST00000395183ENST00000395160ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
5CDS-intronENST00000395183ENST00000513839ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
5CDS-intronENST00000395183ENST00000513839ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
5CDS-intronENST00000395184ENST00000395157ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
5CDS-intronENST00000395184ENST00000395157ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
5CDS-intronENST00000395184ENST00000395160ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
5CDS-intronENST00000395184ENST00000395160ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
5CDS-intronENST00000395184ENST00000513839ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
5CDS-intronENST00000395184ENST00000513839ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
5CDS-intronENST00000503995ENST00000395157ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
5CDS-intronENST00000503995ENST00000395157ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
5CDS-intronENST00000503995ENST00000395160ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
5CDS-intronENST00000503995ENST00000395160ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
5CDS-intronENST00000503995ENST00000513839ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
5CDS-intronENST00000503995ENST00000513839ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
5UTR-5UTRENST00000395183ENST00000359221ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
5UTR-5UTRENST00000395183ENST00000361569ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
5UTR-5UTRENST00000395183ENST00000395161ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
5UTR-5UTRENST00000395183ENST00000395166ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
5UTR-5UTRENST00000395183ENST00000395169ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
5UTR-5UTRENST00000395183ENST00000449047ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
5UTR-5UTRENST00000395183ENST00000513839ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
5UTR-intronENST00000395183ENST00000395157ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
5UTR-intronENST00000395183ENST00000395160ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
Frame-shiftENST00000264343ENST00000359221ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000264343ENST00000359221ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000264343ENST00000395161ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000264343ENST00000395161ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000264343ENST00000395166ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000264343ENST00000395166ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000264343ENST00000449047ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000264343ENST00000449047ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000395183ENST00000359221ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000395183ENST00000359221ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000395183ENST00000395161ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000395183ENST00000395161ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000395183ENST00000395166ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000395183ENST00000395166ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000395183ENST00000449047ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000395183ENST00000449047ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000395184ENST00000359221ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000395184ENST00000359221ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000395184ENST00000395161ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000395184ENST00000395161ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000395184ENST00000395166ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000395184ENST00000395166ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000395184ENST00000449047ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000395184ENST00000449047ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000503995ENST00000359221ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000503995ENST00000359221ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000503995ENST00000395161ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000503995ENST00000395161ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000503995ENST00000395166ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000503995ENST00000395166ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
Frame-shiftENST00000503995ENST00000449047ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
Frame-shiftENST00000503995ENST00000449047ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
In-frameENST00000264343ENST00000361569ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
In-frameENST00000264343ENST00000361569ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
In-frameENST00000264343ENST00000395169ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
In-frameENST00000264343ENST00000395169ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
In-frameENST00000395183ENST00000361569ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
In-frameENST00000395183ENST00000361569ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
In-frameENST00000395183ENST00000395169ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
In-frameENST00000395183ENST00000395169ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
In-frameENST00000395184ENST00000361569ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
In-frameENST00000395184ENST00000361569ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
In-frameENST00000395184ENST00000395169ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
In-frameENST00000395184ENST00000395169ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
In-frameENST00000503995ENST00000361569ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
In-frameENST00000503995ENST00000361569ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
In-frameENST00000503995ENST00000395169ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
In-frameENST00000503995ENST00000395169ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
intron-3CDSENST00000506421ENST00000359221ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
intron-3CDSENST00000506421ENST00000359221ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
intron-3CDSENST00000506421ENST00000361569ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
intron-3CDSENST00000506421ENST00000361569ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
intron-3CDSENST00000506421ENST00000395161ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
intron-3CDSENST00000506421ENST00000395161ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
intron-3CDSENST00000506421ENST00000395166ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
intron-3CDSENST00000506421ENST00000395166ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
intron-3CDSENST00000506421ENST00000395169ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
intron-3CDSENST00000506421ENST00000395169ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
intron-3CDSENST00000506421ENST00000449047ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
intron-3CDSENST00000506421ENST00000449047ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
intron-5UTRENST00000264343ENST00000359221ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000264343ENST00000361569ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000264343ENST00000395161ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000264343ENST00000395166ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000264343ENST00000395169ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000264343ENST00000449047ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000264343ENST00000513839ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000395184ENST00000359221ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000395184ENST00000361569ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000395184ENST00000395161ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000395184ENST00000395166ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000395184ENST00000395169ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000395184ENST00000449047ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000395184ENST00000513839ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000503995ENST00000359221ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000503995ENST00000361569ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000503995ENST00000395161ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000503995ENST00000395166ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000503995ENST00000395169ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000503995ENST00000449047ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000503995ENST00000513839ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000506421ENST00000359221ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000506421ENST00000361569ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000506421ENST00000395161ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000506421ENST00000395166ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000506421ENST00000395169ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000506421ENST00000449047ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-5UTRENST00000506421ENST00000513839ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-intronENST00000264343ENST00000395157ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-intronENST00000264343ENST00000395160ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-intronENST00000395184ENST00000395157ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-intronENST00000395184ENST00000395160ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-intronENST00000503995ENST00000395157ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-intronENST00000503995ENST00000395160ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-intronENST00000506421ENST00000395157ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-intronENST00000506421ENST00000395157ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
intron-intronENST00000506421ENST00000395157ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
intron-intronENST00000506421ENST00000395160ARHGAP24chr4

86700118

+MAPK10chr4

87115560

-
intron-intronENST00000506421ENST00000395160ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
intron-intronENST00000506421ENST00000395160ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-
intron-intronENST00000506421ENST00000513839ARHGAP24chr4

86863426

+MAPK10chr4

86938528

-
intron-intronENST00000506421ENST00000513839ARHGAP24chr4

86863426

+MAPK10chr4

86938523

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for ARHGAP24-MAPK10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARHGAP24-MAPK10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:86700118/chr4:87115560)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP24

Q8N264

MAPK10

P53779

FUNCTION: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. {ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}.FUNCTION: Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296). {ECO:0000269|PubMed:11718727, ECO:0000269|PubMed:22327296, ECO:0000269|PubMed:22441692}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP24chr4:86863426chr4:86938523ENST00000395184+51019_125199749.0DomainPH
HgeneARHGAP24chr4:86863426chr4:86938523ENST00000503995+5619_125199247.0DomainPH
HgeneARHGAP24chr4:86863426chr4:86938528ENST00000395184+51019_125199749.0DomainPH
HgeneARHGAP24chr4:86863426chr4:86938528ENST00000503995+5619_125199247.0DomainPH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP24chr4:86863426chr4:86938523ENST00000264343+27649_729106656.0Coiled coilOntology_term=ECO:0000255
HgeneARHGAP24chr4:86863426chr4:86938523ENST00000395183+38649_729104654.0Coiled coilOntology_term=ECO:0000255
HgeneARHGAP24chr4:86863426chr4:86938523ENST00000395184+510649_729199749.0Coiled coilOntology_term=ECO:0000255
HgeneARHGAP24chr4:86863426chr4:86938523ENST00000503995+56649_729199247.0Coiled coilOntology_term=ECO:0000255
HgeneARHGAP24chr4:86863426chr4:86938528ENST00000264343+27649_729106656.0Coiled coilOntology_term=ECO:0000255
HgeneARHGAP24chr4:86863426chr4:86938528ENST00000395183+38649_729104654.0Coiled coilOntology_term=ECO:0000255
HgeneARHGAP24chr4:86863426chr4:86938528ENST00000395184+510649_729199749.0Coiled coilOntology_term=ECO:0000255
HgeneARHGAP24chr4:86863426chr4:86938528ENST00000503995+56649_729199247.0Coiled coilOntology_term=ECO:0000255
HgeneARHGAP24chr4:86863426chr4:86938523ENST00000264343+27135_329106656.0DomainRho-GAP
HgeneARHGAP24chr4:86863426chr4:86938523ENST00000264343+2719_125106656.0DomainPH
HgeneARHGAP24chr4:86863426chr4:86938523ENST00000395183+38135_329104654.0DomainRho-GAP
HgeneARHGAP24chr4:86863426chr4:86938523ENST00000395183+3819_125104654.0DomainPH
HgeneARHGAP24chr4:86863426chr4:86938523ENST00000395184+510135_329199749.0DomainRho-GAP
HgeneARHGAP24chr4:86863426chr4:86938523ENST00000503995+56135_329199247.0DomainRho-GAP
HgeneARHGAP24chr4:86863426chr4:86938528ENST00000264343+27135_329106656.0DomainRho-GAP
HgeneARHGAP24chr4:86863426chr4:86938528ENST00000264343+2719_125106656.0DomainPH
HgeneARHGAP24chr4:86863426chr4:86938528ENST00000395183+38135_329104654.0DomainRho-GAP
HgeneARHGAP24chr4:86863426chr4:86938528ENST00000395183+3819_125104654.0DomainPH
HgeneARHGAP24chr4:86863426chr4:86938528ENST00000395184+510135_329199749.0DomainRho-GAP
HgeneARHGAP24chr4:86863426chr4:86938528ENST00000503995+56135_329199247.0DomainRho-GAP
TgeneMAPK10chr4:86863426chr4:86938523ENST00000359221121464_359417465.0DomainProtein kinase
TgeneMAPK10chr4:86863426chr4:86938523ENST00000361569121464_359417423.0DomainProtein kinase
TgeneMAPK10chr4:86863426chr4:86938523ENST000003951607964_359272278.0DomainProtein kinase
TgeneMAPK10chr4:86863426chr4:86938523ENST00000395161121464_359417423.0DomainProtein kinase
TgeneMAPK10chr4:86863426chr4:86938523ENST00000395166121464_359379427.0DomainProtein kinase
TgeneMAPK10chr4:86863426chr4:86938523ENST00000395169121464_359379427.0DomainProtein kinase
TgeneMAPK10chr4:86863426chr4:86938528ENST00000359221121464_359417465.0DomainProtein kinase
TgeneMAPK10chr4:86863426chr4:86938528ENST00000361569121464_359417423.0DomainProtein kinase
TgeneMAPK10chr4:86863426chr4:86938528ENST000003951607964_359272278.0DomainProtein kinase
TgeneMAPK10chr4:86863426chr4:86938528ENST00000395161121464_359417423.0DomainProtein kinase
TgeneMAPK10chr4:86863426chr4:86938528ENST00000395166121464_359379427.0DomainProtein kinase
TgeneMAPK10chr4:86863426chr4:86938528ENST00000395169121464_359379427.0DomainProtein kinase
TgeneMAPK10chr4:86863426chr4:86938523ENST000003592211214221_223417465.0MotifNote=TXY
TgeneMAPK10chr4:86863426chr4:86938523ENST000003615691214221_223417423.0MotifNote=TXY
TgeneMAPK10chr4:86863426chr4:86938523ENST0000039516079221_223272278.0MotifNote=TXY
TgeneMAPK10chr4:86863426chr4:86938523ENST000003951611214221_223417423.0MotifNote=TXY
TgeneMAPK10chr4:86863426chr4:86938523ENST000003951661214221_223379427.0MotifNote=TXY
TgeneMAPK10chr4:86863426chr4:86938523ENST000003951691214221_223379427.0MotifNote=TXY
TgeneMAPK10chr4:86863426chr4:86938528ENST000003592211214221_223417465.0MotifNote=TXY
TgeneMAPK10chr4:86863426chr4:86938528ENST000003615691214221_223417423.0MotifNote=TXY
TgeneMAPK10chr4:86863426chr4:86938528ENST0000039516079221_223272278.0MotifNote=TXY
TgeneMAPK10chr4:86863426chr4:86938528ENST000003951611214221_223417423.0MotifNote=TXY
TgeneMAPK10chr4:86863426chr4:86938528ENST000003951661214221_223379427.0MotifNote=TXY
TgeneMAPK10chr4:86863426chr4:86938528ENST000003951691214221_223379427.0MotifNote=TXY
TgeneMAPK10chr4:86863426chr4:86938523ENST00000359221121470_78417465.0Nucleotide bindingNote=ATP
TgeneMAPK10chr4:86863426chr4:86938523ENST00000361569121470_78417423.0Nucleotide bindingNote=ATP
TgeneMAPK10chr4:86863426chr4:86938523ENST000003951607970_78272278.0Nucleotide bindingNote=ATP
TgeneMAPK10chr4:86863426chr4:86938523ENST00000395161121470_78417423.0Nucleotide bindingNote=ATP
TgeneMAPK10chr4:86863426chr4:86938523ENST00000395166121470_78379427.0Nucleotide bindingNote=ATP
TgeneMAPK10chr4:86863426chr4:86938523ENST00000395169121470_78379427.0Nucleotide bindingNote=ATP
TgeneMAPK10chr4:86863426chr4:86938528ENST00000359221121470_78417465.0Nucleotide bindingNote=ATP
TgeneMAPK10chr4:86863426chr4:86938528ENST00000361569121470_78417423.0Nucleotide bindingNote=ATP
TgeneMAPK10chr4:86863426chr4:86938528ENST000003951607970_78272278.0Nucleotide bindingNote=ATP
TgeneMAPK10chr4:86863426chr4:86938528ENST00000395161121470_78417423.0Nucleotide bindingNote=ATP
TgeneMAPK10chr4:86863426chr4:86938528ENST00000395166121470_78379427.0Nucleotide bindingNote=ATP
TgeneMAPK10chr4:86863426chr4:86938528ENST00000395169121470_78379427.0Nucleotide bindingNote=ATP


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Fusion Gene Sequence for ARHGAP24-MAPK10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ARHGAP24-MAPK10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGAP24-MAPK10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGAP24-MAPK10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource