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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NR6A1-GOLGA1 (FusionGDB2 ID:60189)

Fusion Gene Summary for NR6A1-GOLGA1

Fusion gene summary

Fusion gene information	Fusion gene name: NR6A1-GOLGA1
	Fusion gene ID: 60189
		Hgene	Tgene
	Gene symbol	NR6A1	GOLGA1
	Gene ID	2649	2800
	Gene name	nuclear receptor subfamily 6 group A member 1	golgin A1
	Synonyms	CT150\|GCNF\|GCNF1\|NR61\|RTR\|hGCNF\|hRTR	golgin-97
	Cytomap	9q33.3	9q33.3
	Type of gene	protein-coding	protein-coding
	Description	nuclear receptor subfamily 6 group A member 1germ cell nuclear factor variant 1retinoic acid receptor-related testis-associated receptorretinoid receptor-related testis-specific receptor	golgin subfamily A member 1gap junction protein, alpha 4, 37kDgolgi autoantigen, golgin subfamily a, 1
	Modification date	20200313	20200313
	UniProtAcc	Q15406	Q92805
	Ensembl transtripts involved in fusion gene	ENST00000344523, ENST00000373584, ENST00000416460, ENST00000487099,	ENST00000373555,
Fusion gene scores	* DoF score	4 X 5 X 5=100	5 X 6 X 7=210
	# samples	8	10
	** MAII score	log2(8/100*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/210*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NR6A1 [Title/Abstract] AND GOLGA1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NR6A1(127495586)-GOLGA1(127662826), # samples:2
Anticipated loss of major functional domain due to fusion event.	NR6A1-GOLGA1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. NR6A1-GOLGA1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across NR6A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GOLGA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	CESC	TCGA-VS-A9UT-01A	NR6A1	chr9	127495587	-	GOLGA1	chr9	127701145	-
ChimerDB4	OV	TCGA-24-2026	NR6A1	chr9	127495586	-	GOLGA1	chr9	127662826	-
ChimerDB4	OV	TCGA-25-2397-01A	NR6A1	chr9	127495587	-	GOLGA1	chr9	127652757	-
ChimerDB4	OV	TCGA-25-2397	NR6A1	chr9	127495586	-	GOLGA1	chr9	127652757	-
ChimerDB4	SKCM	TCGA-ER-A19T-01A	NR6A1	chr9	127533299	-	GOLGA1	chr9	127644848	-
ChimerDB4	UCEC	TCGA-B5-A11J	NR6A1	chr9	127495586	-	GOLGA1	chr9	127662826	-

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Fusion Gene ORF analysis for NR6A1-GOLGA1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000344523	ENST00000373555	NR6A1	chr9	127495587	-	GOLGA1	chr9	127701145	-
5CDS-5UTR	ENST00000373584	ENST00000373555	NR6A1	chr9	127495587	-	GOLGA1	chr9	127701145	-
5CDS-5UTR	ENST00000416460	ENST00000373555	NR6A1	chr9	127495587	-	GOLGA1	chr9	127701145	-
5CDS-5UTR	ENST00000487099	ENST00000373555	NR6A1	chr9	127495587	-	GOLGA1	chr9	127701145	-
Frame-shift	ENST00000344523	ENST00000373555	NR6A1	chr9	127495586	-	GOLGA1	chr9	127662826	-
Frame-shift	ENST00000344523	ENST00000373555	NR6A1	chr9	127495587	-	GOLGA1	chr9	127652757	-
Frame-shift	ENST00000344523	ENST00000373555	NR6A1	chr9	127495586	-	GOLGA1	chr9	127652757	-
Frame-shift	ENST00000373584	ENST00000373555	NR6A1	chr9	127495586	-	GOLGA1	chr9	127662826	-
Frame-shift	ENST00000373584	ENST00000373555	NR6A1	chr9	127495587	-	GOLGA1	chr9	127652757	-
Frame-shift	ENST00000373584	ENST00000373555	NR6A1	chr9	127495586	-	GOLGA1	chr9	127652757	-
Frame-shift	ENST00000416460	ENST00000373555	NR6A1	chr9	127495586	-	GOLGA1	chr9	127662826	-
Frame-shift	ENST00000416460	ENST00000373555	NR6A1	chr9	127495587	-	GOLGA1	chr9	127652757	-
Frame-shift	ENST00000416460	ENST00000373555	NR6A1	chr9	127495586	-	GOLGA1	chr9	127652757	-
Frame-shift	ENST00000487099	ENST00000373555	NR6A1	chr9	127495586	-	GOLGA1	chr9	127662826	-
Frame-shift	ENST00000487099	ENST00000373555	NR6A1	chr9	127495587	-	GOLGA1	chr9	127652757	-
Frame-shift	ENST00000487099	ENST00000373555	NR6A1	chr9	127495586	-	GOLGA1	chr9	127652757	-
In-frame	ENST00000344523	ENST00000373555	NR6A1	chr9	127533299	-	GOLGA1	chr9	127644848	-
In-frame	ENST00000373584	ENST00000373555	NR6A1	chr9	127533299	-	GOLGA1	chr9	127644848	-
In-frame	ENST00000416460	ENST00000373555	NR6A1	chr9	127533299	-	GOLGA1	chr9	127644848	-
In-frame	ENST00000487099	ENST00000373555	NR6A1	chr9	127533299	-	GOLGA1	chr9	127644848	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000487099	NR6A1	chr9	127533299	-	ENST00000373555	GOLGA1	chr9	127644848	-	2820	258	270	656	128
ENST00000373584	NR6A1	chr9	127533299	-	ENST00000373555	GOLGA1	chr9	127644848	-	2840	278	290	676	128
ENST00000416460	NR6A1	chr9	127533299	-	ENST00000373555	GOLGA1	chr9	127644848	-	2853	291	303	689	128
ENST00000344523	NR6A1	chr9	127533299	-	ENST00000373555	GOLGA1	chr9	127644848	-	2830	268	280	666	128

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000487099	ENST00000373555	NR6A1	chr9	127533299	-	GOLGA1	chr9	127644848	-	0.020481583	0.97951835
ENST00000373584	ENST00000373555	NR6A1	chr9	127533299	-	GOLGA1	chr9	127644848	-	0.00870422	0.9912958
ENST00000416460	ENST00000373555	NR6A1	chr9	127533299	-	GOLGA1	chr9	127644848	-	0.009689451	0.9903106
ENST00000344523	ENST00000373555	NR6A1	chr9	127533299	-	GOLGA1	chr9	127644848	-	0.010252192	0.9897479

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Fusion Genomic Features for NR6A1-GOLGA1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NR6A1-GOLGA1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:127495586/chr9:127662826)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NR6A1 Q15406	GOLGA1 Q92805
FUNCTION: Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity). {ECO:0000250}.	FUNCTION: Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking. {ECO:0000269\|PubMed:29084197}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

GOLGA1

chr9:127533299

chr9:127644848

ENST00000373555

688_737

635

768.0

Domain

GRIP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NR6A1

chr9:127533299

chr9:127644848

ENST00000344523

57_132

480.0

DNA binding

Nuclear receptor

Hgene

NR6A1

chr9:127533299

chr9:127644848

ENST00000373584

57_132

477.0

DNA binding

Nuclear receptor

Hgene

NR6A1

chr9:127533299

chr9:127644848

ENST00000416460

57_132

476.0

DNA binding

Nuclear receptor

Hgene

NR6A1

chr9:127533299

chr9:127644848

ENST00000487099

57_132

481.0

DNA binding

Nuclear receptor

Hgene

NR6A1

chr9:127533299

chr9:127644848

ENST00000344523

249_480

480.0

Domain

NR LBD

Hgene

NR6A1

chr9:127533299

chr9:127644848

ENST00000373584

249_480

477.0

Domain

NR LBD

Hgene

NR6A1

chr9:127533299

chr9:127644848

ENST00000416460

249_480

476.0

Domain

NR LBD

Hgene

NR6A1

chr9:127533299

chr9:127644848

ENST00000487099

249_480

481.0

Domain

NR LBD

Hgene

NR6A1

chr9:127533299

chr9:127644848

ENST00000344523

60_80

480.0

Zinc finger

NR C4-type

Hgene

NR6A1

chr9:127533299

chr9:127644848

ENST00000344523

96_120

480.0

Zinc finger

NR C4-type

Hgene

NR6A1

chr9:127533299

chr9:127644848

ENST00000373584

60_80

477.0

Zinc finger

NR C4-type

Hgene

NR6A1

chr9:127533299

chr9:127644848

ENST00000373584

96_120

477.0

Zinc finger

NR C4-type

Hgene

NR6A1

chr9:127533299

chr9:127644848

ENST00000416460

60_80

476.0

Zinc finger

NR C4-type

Hgene

NR6A1

chr9:127533299

chr9:127644848

ENST00000416460

96_120

476.0

Zinc finger

NR C4-type

Hgene

NR6A1

chr9:127533299

chr9:127644848

ENST00000487099

60_80

481.0

Zinc finger

NR C4-type

Hgene

NR6A1

chr9:127533299

chr9:127644848

ENST00000487099

96_120

481.0

Zinc finger

NR C4-type

Tgene

GOLGA1

chr9:127533299

chr9:127644848

ENST00000373555

50_657

635

768.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

GOLGA1

chr9:127533299

chr9:127644848

ENST00000373555

361_546

635

768.0

Compositional bias

Note=Gln-rich

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Fusion Gene Sequence for NR6A1-GOLGA1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>60189_60189_1_NR6A1-GOLGA1_NR6A1_chr9_127533299_ENST00000344523_GOLGA1_chr9_127644848_ENST00000373555_length(transcript)=2830nt_BP=268nt
GGGGCGCGGAGCGGCGCGGAGCCGGGCGGCTCGGGGCCCAGAGAGAGCCGCGGCCGGGAGCTCGCGGGCTCCTGACAACCTCCTCCCCTC
GGCGGACGACGACCACGGCGACTAGGGCGCCGGTCATGGCGGAGCAACAAACCCGGCGCGGACCCTAGGCACCACCGCATGGAGCGGGAC
GAACCGCCGCCTAGCGGAGGGGGAGGCGGCGGGGGCTCGGCGGGGTTCCTGGAGCCTCCCGCCGCGCTCCCTCCGCCGCCGCGCAACGAC
CATAAAGCAGATGCAGCAGCGGATGCTGGAGCTCCGGAAGACTCTGCAGAAGGAGCTGAAAATCAGACCCGATAATGAGCTCTTCGAAGT
CCGGGAGAAACCTGGACCTGAGATGGCAAACATGGCGCCTTCCGTCACGAATAACACTGACCTGACAGATGCCCGCGAGATCAACTTTGA
GTACCTTAAACATGTGGTTTTAAAATTCATGTCTTGTCGCGAATCCGAGGCTTTTCATCTTATAAAAGCTGTGTCAGTGTTGCTGAACTT
TTCCCAAGAGGAGGAGAACATGCTCAAGGAAACTCTGGAATATAAGATGTCATGGTTTGGGTCCAAACCAGCTCCCAAGGGCAGCATCCG
GCCGTCTATCTCAAACCCTCGGATACCATGGTCCTAGAGGGGACTACCCAAGGATGGAGCTCCGTGGGTTGACACTTTTTCTGTGAAAAG
AACACTGACACACCAGTCTGGGTGGGTTTTTAATCACTGTAACTGCAGTATTTTGTACAAGTGTCTAAACATTGTTTACAAGACTAAGGC
CCACTTCCCTGCAGGCTGACCTGAACCTCAGGGGGTAGCTGATCCTGTCATTCTGGTCACCAAACAGGAGGGTCCTGGCACTACCCAGAT
TTCCACAGTGCTGCTAATATCCCAGCTCCAGCCAGCACCCCATCTGCACCTGAATCCTCTAACTTCACGGTAGCACTTACAGCTGAAGCC
ATCAGCATCTGGCAGGCACACCTGAGTCACCATGTAGCGCTGCTACTGGAGGTAGAGACGGCCCTTTGAGATGGTGCCCAGCAGGCCAAA
CCCACCTGCCTCTGCCAGGAACAGCCAACTCCATGGGAACTCTATGGGAGTGGCTTTTAAAAATTCAGATGAGTTAGAAGCTTTTTATCC
CTTCCTCTCAAGAAAATATTCTTTCACCCTGTCTCTCAAACCACCTAGAACTTTAGAGGATCCATCTTTAAGGGTCGGTGTGGATGAATG
AGAAAATGCACCTTTCTGACAGTATCTCCACTTTACTTAAGAAAACTAGCAAATATATGAAAAGACCCTTAGTACCAAATACACTCAATT
GCCTTTTTAATGAATGTACTTGTCTTGGATAGGTTGCTGGTAAACCATTTTAAACTATTTTTTATAGCTGAAGTTCTTCACTACTATAAA
CATGTCTTCTGTACTATAAAATCCATTTAACTGGTGTTCTTAAAATCAGAGCGTCCAGAGGAAATTCTTCCTAAAACTAGGATTCCTGTT
CCTTTGTCTTCTCACTCGCACTCTGGCACTGCTCCCTCTGAAGTGCAGTGGGATCTCGTGTGCTTTGTCTTGATTCTGTGCTGCGCTGCC
GCTGGGCGATGCAGACCACCTGTCTTCTACTGAAGGACAGTCCGCTGTCTCCAGTGGGGGCAGCAGCTGTCCCCCAGCCTCGATGGAGAC
ACTGGGGCAGTCTGCCTTGTCTGTGGAGCTGCTCTCTCTCCCTCATCCCACCCCAAATACTTAAAATGACACTACACCCAGACGGCGCCC
AGCTGGCTGCAGCACTTGTAGCATGCACATGACTCTGGTAGTAACCAACAAAAACTTGTTTTATGGATTCCTCGTTTACTGAGGAAAGGG
AACATGCTGGTTCTGGAAAAGCCACAATATTGAATCTAAAAGGAAACCGTTTATTGTTTGATGAAAGTTTCACTGGTTAAATAAAAAACT
AAATTAATAACTGGAGCCTCTAAATTTATTATCCATTATCCAGTGATGGAAAGTTGTATTTCTCAATCATGCTTAGGGCCAAAATAGGTA
TATAAAATGTGTCACAGAAAAACACGCATTTGCAACGTTAACCTAACGAAATTTCCATGAAGAACCAAGTCAGGGCAGCATCTCCTTAGT
CCCAGCTCAGGCTCTCTGCCTTCCAGAGGCCGCTTCTCCAGTGACTAACCTCCTCCTCTGGCTCCTCCTTGCAGACAGTTATCCCTTGTT
TAGAACACGAATTTCCATTTACCTGGTGGGAACACGAAACAGGAGTCTCTTCTGTTCTGCAAGTTTGATGGGTAAGAGGTAGCCTTTTTT
CAAAGTAGGATTTCCTTTTTCAACTGTTCCAGGAAAGAATCTCTAAGACTGGGTAGCTCACAGCCAGCCAAAGGCAGCTACATTTCCACA
GAAGCCCATCCGCTGCCTCCGTGGCTTCTCCAGCCATTGAACTGGTCCCACACGCACCCCAGGCCCCACTCCTCGGCAGTTTCAGGTGTA
GCTGTGGGGCCCGTTCCTAGGTCTGTACTCACTTTAGGGAGGCTTCACTGACTAGGCTTTCCTCCTGCATGTTGAATTTCCTTCAGCTTT
AAGAGGAAGAGTGGAATAAATATTCTAAGTGATTTAATGCACTTTGACTTGTATAAAACTTTCTGTGTTAGCGACGGTATCTATAGCCCT
TTATACGAGCGATGGATCTTGAGCTCTCCTTCCATGTTGTAAATAGGGATTGTATTCTTGAAAACTGCTGTAGCAAATTCATCTGTGGTG

>60189_60189_1_NR6A1-GOLGA1_NR6A1_chr9_127533299_ENST00000344523_GOLGA1_chr9_127644848_ENST00000373555_length(amino acids)=128AA_BP=
MQQRMLELRKTLQKELKIRPDNELFEVREKPGPEMANMAPSVTNNTDLTDAREINFEYLKHVVLKFMSCRESEAFHLIKAVSVLLNFSQE

--------------------------------------------------------------
>60189_60189_2_NR6A1-GOLGA1_NR6A1_chr9_127533299_ENST00000373584_GOLGA1_chr9_127644848_ENST00000373555_length(transcript)=2840nt_BP=278nt
GCGGCGCGGAGGGGCGCGGAGCGGCGCGGAGCCGGGCGGCTCGGGGCCCAGAGAGAGCCGCGGCCGGGAGCTCGCGGGCTCCTGACAACC
TCCTCCCCTCGGCGGACGACGACCACGGCGACTAGGGCGCCGGTCATGGCGGAGCAACAAACCCGGCGCGGACCCTAGGCACCACCGCAT
GGAGCGGGACGAACCGCCGCCTAGCGGAGGGGGAGGCGGCGGGGGCTCGGCGGGGTTCCTGGAGCCTCCCGCCGCGCTCCCTCCGCCGCC
GCGCAACGACCATAAAGCAGATGCAGCAGCGGATGCTGGAGCTCCGGAAGACTCTGCAGAAGGAGCTGAAAATCAGACCCGATAATGAGC
TCTTCGAAGTCCGGGAGAAACCTGGACCTGAGATGGCAAACATGGCGCCTTCCGTCACGAATAACACTGACCTGACAGATGCCCGCGAGA
TCAACTTTGAGTACCTTAAACATGTGGTTTTAAAATTCATGTCTTGTCGCGAATCCGAGGCTTTTCATCTTATAAAAGCTGTGTCAGTGT
TGCTGAACTTTTCCCAAGAGGAGGAGAACATGCTCAAGGAAACTCTGGAATATAAGATGTCATGGTTTGGGTCCAAACCAGCTCCCAAGG
GCAGCATCCGGCCGTCTATCTCAAACCCTCGGATACCATGGTCCTAGAGGGGACTACCCAAGGATGGAGCTCCGTGGGTTGACACTTTTT
CTGTGAAAAGAACACTGACACACCAGTCTGGGTGGGTTTTTAATCACTGTAACTGCAGTATTTTGTACAAGTGTCTAAACATTGTTTACA
AGACTAAGGCCCACTTCCCTGCAGGCTGACCTGAACCTCAGGGGGTAGCTGATCCTGTCATTCTGGTCACCAAACAGGAGGGTCCTGGCA
CTACCCAGATTTCCACAGTGCTGCTAATATCCCAGCTCCAGCCAGCACCCCATCTGCACCTGAATCCTCTAACTTCACGGTAGCACTTAC
AGCTGAAGCCATCAGCATCTGGCAGGCACACCTGAGTCACCATGTAGCGCTGCTACTGGAGGTAGAGACGGCCCTTTGAGATGGTGCCCA
GCAGGCCAAACCCACCTGCCTCTGCCAGGAACAGCCAACTCCATGGGAACTCTATGGGAGTGGCTTTTAAAAATTCAGATGAGTTAGAAG
CTTTTTATCCCTTCCTCTCAAGAAAATATTCTTTCACCCTGTCTCTCAAACCACCTAGAACTTTAGAGGATCCATCTTTAAGGGTCGGTG
TGGATGAATGAGAAAATGCACCTTTCTGACAGTATCTCCACTTTACTTAAGAAAACTAGCAAATATATGAAAAGACCCTTAGTACCAAAT
ACACTCAATTGCCTTTTTAATGAATGTACTTGTCTTGGATAGGTTGCTGGTAAACCATTTTAAACTATTTTTTATAGCTGAAGTTCTTCA
CTACTATAAACATGTCTTCTGTACTATAAAATCCATTTAACTGGTGTTCTTAAAATCAGAGCGTCCAGAGGAAATTCTTCCTAAAACTAG
GATTCCTGTTCCTTTGTCTTCTCACTCGCACTCTGGCACTGCTCCCTCTGAAGTGCAGTGGGATCTCGTGTGCTTTGTCTTGATTCTGTG
CTGCGCTGCCGCTGGGCGATGCAGACCACCTGTCTTCTACTGAAGGACAGTCCGCTGTCTCCAGTGGGGGCAGCAGCTGTCCCCCAGCCT
CGATGGAGACACTGGGGCAGTCTGCCTTGTCTGTGGAGCTGCTCTCTCTCCCTCATCCCACCCCAAATACTTAAAATGACACTACACCCA
GACGGCGCCCAGCTGGCTGCAGCACTTGTAGCATGCACATGACTCTGGTAGTAACCAACAAAAACTTGTTTTATGGATTCCTCGTTTACT
GAGGAAAGGGAACATGCTGGTTCTGGAAAAGCCACAATATTGAATCTAAAAGGAAACCGTTTATTGTTTGATGAAAGTTTCACTGGTTAA
ATAAAAAACTAAATTAATAACTGGAGCCTCTAAATTTATTATCCATTATCCAGTGATGGAAAGTTGTATTTCTCAATCATGCTTAGGGCC
AAAATAGGTATATAAAATGTGTCACAGAAAAACACGCATTTGCAACGTTAACCTAACGAAATTTCCATGAAGAACCAAGTCAGGGCAGCA
TCTCCTTAGTCCCAGCTCAGGCTCTCTGCCTTCCAGAGGCCGCTTCTCCAGTGACTAACCTCCTCCTCTGGCTCCTCCTTGCAGACAGTT
ATCCCTTGTTTAGAACACGAATTTCCATTTACCTGGTGGGAACACGAAACAGGAGTCTCTTCTGTTCTGCAAGTTTGATGGGTAAGAGGT
AGCCTTTTTTCAAAGTAGGATTTCCTTTTTCAACTGTTCCAGGAAAGAATCTCTAAGACTGGGTAGCTCACAGCCAGCCAAAGGCAGCTA
CATTTCCACAGAAGCCCATCCGCTGCCTCCGTGGCTTCTCCAGCCATTGAACTGGTCCCACACGCACCCCAGGCCCCACTCCTCGGCAGT
TTCAGGTGTAGCTGTGGGGCCCGTTCCTAGGTCTGTACTCACTTTAGGGAGGCTTCACTGACTAGGCTTTCCTCCTGCATGTTGAATTTC
CTTCAGCTTTAAGAGGAAGAGTGGAATAAATATTCTAAGTGATTTAATGCACTTTGACTTGTATAAAACTTTCTGTGTTAGCGACGGTAT
CTATAGCCCTTTATACGAGCGATGGATCTTGAGCTCTCCTTCCATGTTGTAAATAGGGATTGTATTCTTGAAAACTGCTGTAGCAAATTC

>60189_60189_2_NR6A1-GOLGA1_NR6A1_chr9_127533299_ENST00000373584_GOLGA1_chr9_127644848_ENST00000373555_length(amino acids)=128AA_BP=
MQQRMLELRKTLQKELKIRPDNELFEVREKPGPEMANMAPSVTNNTDLTDAREINFEYLKHVVLKFMSCRESEAFHLIKAVSVLLNFSQE

--------------------------------------------------------------
>60189_60189_3_NR6A1-GOLGA1_NR6A1_chr9_127533299_ENST00000416460_GOLGA1_chr9_127644848_ENST00000373555_length(transcript)=2853nt_BP=291nt
GTGCTGAGGGGGCGCGGCGCGGAGGGGCGCGGAGCGGCGCGGAGCCGGGCGGCTCGGGGCCCAGAGAGAGCCGCGGCCGGGAGCTCGCGG
GCTCCTGACAACCTCCTCCCCTCGGCGGACGACGACCACGGCGACTAGGGCGCCGGTCATGGCGGAGCAACAAACCCGGCGCGGACCCTA
GGCACCACCGCATGGAGCGGGACGAACCGCCGCCTAGCGGAGGGGGAGGCGGCGGGGGCTCGGCGGGGTTCCTGGAGCCTCCCGCCGCGC
TCCCTCCGCCGCCGCGCAACGACCATAAAGCAGATGCAGCAGCGGATGCTGGAGCTCCGGAAGACTCTGCAGAAGGAGCTGAAAATCAGA
CCCGATAATGAGCTCTTCGAAGTCCGGGAGAAACCTGGACCTGAGATGGCAAACATGGCGCCTTCCGTCACGAATAACACTGACCTGACA
GATGCCCGCGAGATCAACTTTGAGTACCTTAAACATGTGGTTTTAAAATTCATGTCTTGTCGCGAATCCGAGGCTTTTCATCTTATAAAA
GCTGTGTCAGTGTTGCTGAACTTTTCCCAAGAGGAGGAGAACATGCTCAAGGAAACTCTGGAATATAAGATGTCATGGTTTGGGTCCAAA
CCAGCTCCCAAGGGCAGCATCCGGCCGTCTATCTCAAACCCTCGGATACCATGGTCCTAGAGGGGACTACCCAAGGATGGAGCTCCGTGG
GTTGACACTTTTTCTGTGAAAAGAACACTGACACACCAGTCTGGGTGGGTTTTTAATCACTGTAACTGCAGTATTTTGTACAAGTGTCTA
AACATTGTTTACAAGACTAAGGCCCACTTCCCTGCAGGCTGACCTGAACCTCAGGGGGTAGCTGATCCTGTCATTCTGGTCACCAAACAG
GAGGGTCCTGGCACTACCCAGATTTCCACAGTGCTGCTAATATCCCAGCTCCAGCCAGCACCCCATCTGCACCTGAATCCTCTAACTTCA
CGGTAGCACTTACAGCTGAAGCCATCAGCATCTGGCAGGCACACCTGAGTCACCATGTAGCGCTGCTACTGGAGGTAGAGACGGCCCTTT
GAGATGGTGCCCAGCAGGCCAAACCCACCTGCCTCTGCCAGGAACAGCCAACTCCATGGGAACTCTATGGGAGTGGCTTTTAAAAATTCA
GATGAGTTAGAAGCTTTTTATCCCTTCCTCTCAAGAAAATATTCTTTCACCCTGTCTCTCAAACCACCTAGAACTTTAGAGGATCCATCT
TTAAGGGTCGGTGTGGATGAATGAGAAAATGCACCTTTCTGACAGTATCTCCACTTTACTTAAGAAAACTAGCAAATATATGAAAAGACC
CTTAGTACCAAATACACTCAATTGCCTTTTTAATGAATGTACTTGTCTTGGATAGGTTGCTGGTAAACCATTTTAAACTATTTTTTATAG
CTGAAGTTCTTCACTACTATAAACATGTCTTCTGTACTATAAAATCCATTTAACTGGTGTTCTTAAAATCAGAGCGTCCAGAGGAAATTC
TTCCTAAAACTAGGATTCCTGTTCCTTTGTCTTCTCACTCGCACTCTGGCACTGCTCCCTCTGAAGTGCAGTGGGATCTCGTGTGCTTTG
TCTTGATTCTGTGCTGCGCTGCCGCTGGGCGATGCAGACCACCTGTCTTCTACTGAAGGACAGTCCGCTGTCTCCAGTGGGGGCAGCAGC
TGTCCCCCAGCCTCGATGGAGACACTGGGGCAGTCTGCCTTGTCTGTGGAGCTGCTCTCTCTCCCTCATCCCACCCCAAATACTTAAAAT
GACACTACACCCAGACGGCGCCCAGCTGGCTGCAGCACTTGTAGCATGCACATGACTCTGGTAGTAACCAACAAAAACTTGTTTTATGGA
TTCCTCGTTTACTGAGGAAAGGGAACATGCTGGTTCTGGAAAAGCCACAATATTGAATCTAAAAGGAAACCGTTTATTGTTTGATGAAAG
TTTCACTGGTTAAATAAAAAACTAAATTAATAACTGGAGCCTCTAAATTTATTATCCATTATCCAGTGATGGAAAGTTGTATTTCTCAAT
CATGCTTAGGGCCAAAATAGGTATATAAAATGTGTCACAGAAAAACACGCATTTGCAACGTTAACCTAACGAAATTTCCATGAAGAACCA
AGTCAGGGCAGCATCTCCTTAGTCCCAGCTCAGGCTCTCTGCCTTCCAGAGGCCGCTTCTCCAGTGACTAACCTCCTCCTCTGGCTCCTC
CTTGCAGACAGTTATCCCTTGTTTAGAACACGAATTTCCATTTACCTGGTGGGAACACGAAACAGGAGTCTCTTCTGTTCTGCAAGTTTG
ATGGGTAAGAGGTAGCCTTTTTTCAAAGTAGGATTTCCTTTTTCAACTGTTCCAGGAAAGAATCTCTAAGACTGGGTAGCTCACAGCCAG
CCAAAGGCAGCTACATTTCCACAGAAGCCCATCCGCTGCCTCCGTGGCTTCTCCAGCCATTGAACTGGTCCCACACGCACCCCAGGCCCC
ACTCCTCGGCAGTTTCAGGTGTAGCTGTGGGGCCCGTTCCTAGGTCTGTACTCACTTTAGGGAGGCTTCACTGACTAGGCTTTCCTCCTG
CATGTTGAATTTCCTTCAGCTTTAAGAGGAAGAGTGGAATAAATATTCTAAGTGATTTAATGCACTTTGACTTGTATAAAACTTTCTGTG
TTAGCGACGGTATCTATAGCCCTTTATACGAGCGATGGATCTTGAGCTCTCCTTCCATGTTGTAAATAGGGATTGTATTCTTGAAAACTG

>60189_60189_3_NR6A1-GOLGA1_NR6A1_chr9_127533299_ENST00000416460_GOLGA1_chr9_127644848_ENST00000373555_length(amino acids)=128AA_BP=
MQQRMLELRKTLQKELKIRPDNELFEVREKPGPEMANMAPSVTNNTDLTDAREINFEYLKHVVLKFMSCRESEAFHLIKAVSVLLNFSQE

--------------------------------------------------------------
>60189_60189_4_NR6A1-GOLGA1_NR6A1_chr9_127533299_ENST00000487099_GOLGA1_chr9_127644848_ENST00000373555_length(transcript)=2820nt_BP=258nt
GCGGCGCGGAGCCGGGCGGCTCGGGGCCCAGAGAGAGCCGCGGCCGGGAGCTCGCGGGCTCCTGACAACCTCCTCCCCTCGGCGGACGAC
GACCACGGCGACTAGGGCGCCGGTCATGGCGGAGCAACAAACCCGGCGCGGACCCTAGGCACCACCGCATGGAGCGGGACGAACCGCCGC
CTAGCGGAGGGGGAGGCGGCGGGGGCTCGGCGGGGTTCCTGGAGCCTCCCGCCGCGCTCCCTCCGCCGCCGCGCAACGACCATAAAGCAG
ATGCAGCAGCGGATGCTGGAGCTCCGGAAGACTCTGCAGAAGGAGCTGAAAATCAGACCCGATAATGAGCTCTTCGAAGTCCGGGAGAAA
CCTGGACCTGAGATGGCAAACATGGCGCCTTCCGTCACGAATAACACTGACCTGACAGATGCCCGCGAGATCAACTTTGAGTACCTTAAA
CATGTGGTTTTAAAATTCATGTCTTGTCGCGAATCCGAGGCTTTTCATCTTATAAAAGCTGTGTCAGTGTTGCTGAACTTTTCCCAAGAG
GAGGAGAACATGCTCAAGGAAACTCTGGAATATAAGATGTCATGGTTTGGGTCCAAACCAGCTCCCAAGGGCAGCATCCGGCCGTCTATC
TCAAACCCTCGGATACCATGGTCCTAGAGGGGACTACCCAAGGATGGAGCTCCGTGGGTTGACACTTTTTCTGTGAAAAGAACACTGACA
CACCAGTCTGGGTGGGTTTTTAATCACTGTAACTGCAGTATTTTGTACAAGTGTCTAAACATTGTTTACAAGACTAAGGCCCACTTCCCT
GCAGGCTGACCTGAACCTCAGGGGGTAGCTGATCCTGTCATTCTGGTCACCAAACAGGAGGGTCCTGGCACTACCCAGATTTCCACAGTG
CTGCTAATATCCCAGCTCCAGCCAGCACCCCATCTGCACCTGAATCCTCTAACTTCACGGTAGCACTTACAGCTGAAGCCATCAGCATCT
GGCAGGCACACCTGAGTCACCATGTAGCGCTGCTACTGGAGGTAGAGACGGCCCTTTGAGATGGTGCCCAGCAGGCCAAACCCACCTGCC
TCTGCCAGGAACAGCCAACTCCATGGGAACTCTATGGGAGTGGCTTTTAAAAATTCAGATGAGTTAGAAGCTTTTTATCCCTTCCTCTCA
AGAAAATATTCTTTCACCCTGTCTCTCAAACCACCTAGAACTTTAGAGGATCCATCTTTAAGGGTCGGTGTGGATGAATGAGAAAATGCA
CCTTTCTGACAGTATCTCCACTTTACTTAAGAAAACTAGCAAATATATGAAAAGACCCTTAGTACCAAATACACTCAATTGCCTTTTTAA
TGAATGTACTTGTCTTGGATAGGTTGCTGGTAAACCATTTTAAACTATTTTTTATAGCTGAAGTTCTTCACTACTATAAACATGTCTTCT
GTACTATAAAATCCATTTAACTGGTGTTCTTAAAATCAGAGCGTCCAGAGGAAATTCTTCCTAAAACTAGGATTCCTGTTCCTTTGTCTT
CTCACTCGCACTCTGGCACTGCTCCCTCTGAAGTGCAGTGGGATCTCGTGTGCTTTGTCTTGATTCTGTGCTGCGCTGCCGCTGGGCGAT
GCAGACCACCTGTCTTCTACTGAAGGACAGTCCGCTGTCTCCAGTGGGGGCAGCAGCTGTCCCCCAGCCTCGATGGAGACACTGGGGCAG
TCTGCCTTGTCTGTGGAGCTGCTCTCTCTCCCTCATCCCACCCCAAATACTTAAAATGACACTACACCCAGACGGCGCCCAGCTGGCTGC
AGCACTTGTAGCATGCACATGACTCTGGTAGTAACCAACAAAAACTTGTTTTATGGATTCCTCGTTTACTGAGGAAAGGGAACATGCTGG
TTCTGGAAAAGCCACAATATTGAATCTAAAAGGAAACCGTTTATTGTTTGATGAAAGTTTCACTGGTTAAATAAAAAACTAAATTAATAA
CTGGAGCCTCTAAATTTATTATCCATTATCCAGTGATGGAAAGTTGTATTTCTCAATCATGCTTAGGGCCAAAATAGGTATATAAAATGT
GTCACAGAAAAACACGCATTTGCAACGTTAACCTAACGAAATTTCCATGAAGAACCAAGTCAGGGCAGCATCTCCTTAGTCCCAGCTCAG
GCTCTCTGCCTTCCAGAGGCCGCTTCTCCAGTGACTAACCTCCTCCTCTGGCTCCTCCTTGCAGACAGTTATCCCTTGTTTAGAACACGA
ATTTCCATTTACCTGGTGGGAACACGAAACAGGAGTCTCTTCTGTTCTGCAAGTTTGATGGGTAAGAGGTAGCCTTTTTTCAAAGTAGGA
TTTCCTTTTTCAACTGTTCCAGGAAAGAATCTCTAAGACTGGGTAGCTCACAGCCAGCCAAAGGCAGCTACATTTCCACAGAAGCCCATC
CGCTGCCTCCGTGGCTTCTCCAGCCATTGAACTGGTCCCACACGCACCCCAGGCCCCACTCCTCGGCAGTTTCAGGTGTAGCTGTGGGGC
CCGTTCCTAGGTCTGTACTCACTTTAGGGAGGCTTCACTGACTAGGCTTTCCTCCTGCATGTTGAATTTCCTTCAGCTTTAAGAGGAAGA
GTGGAATAAATATTCTAAGTGATTTAATGCACTTTGACTTGTATAAAACTTTCTGTGTTAGCGACGGTATCTATAGCCCTTTATACGAGC
GATGGATCTTGAGCTCTCCTTCCATGTTGTAAATAGGGATTGTATTCTTGAAAACTGCTGTAGCAAATTCATCTGTGGTGCAATACACTT

>60189_60189_4_NR6A1-GOLGA1_NR6A1_chr9_127533299_ENST00000487099_GOLGA1_chr9_127644848_ENST00000373555_length(amino acids)=128AA_BP=
MQQRMLELRKTLQKELKIRPDNELFEVREKPGPEMANMAPSVTNNTDLTDAREINFEYLKHVVLKFMSCRESEAFHLIKAVSVLLNFSQE

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Fusion Gene PPI Analysis for NR6A1-GOLGA1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for NR6A1-GOLGA1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for NR6A1-GOLGA1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source