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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NRCAM-NRCAM (FusionGDB2 ID:60226)

Fusion Gene Summary for NRCAM-NRCAM

check button Fusion gene summary
Fusion gene informationFusion gene name: NRCAM-NRCAM
Fusion gene ID: 60226
HgeneTgene
Gene symbol

NRCAM

NRCAM

Gene ID

4897

4897

Gene nameneuronal cell adhesion moleculeneuronal cell adhesion molecule
Synonyms--
Cytomap

7q31.1

7q31.1

Type of geneprotein-codingprotein-coding
Descriptionneuronal cell adhesion moleculeNgCAM-related cell adhesion moleculeneuronal surface protein Bravoneuronal cell adhesion moleculeNgCAM-related cell adhesion moleculeneuronal surface protein Bravo
Modification date2020031320200313
UniProtAcc

Q92823

Q92823

Ensembl transtripts involved in fusion geneENST00000351718, ENST00000379022, 
ENST00000379024, ENST00000379028, 
ENST00000413765, ENST00000425651, 
ENST00000522550, 		ENST00000351718, 
ENST00000379024, ENST00000379028, 
ENST00000413765, ENST00000522550, 
ENST00000379022, ENST00000425651, 
Fusion gene scores* DoF score11 X 8 X 7=6167 X 5 X 5=175
# samples 127
** MAII scorelog2(12/616*10)=-2.35989594508638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NRCAM [Title/Abstract] AND NRCAM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNRCAM(107788350)-NRCAM(107789159), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNRCAM

GO:0045162

clustering of voltage-gated sodium channels

14602817

TgeneNRCAM

GO:0045162

clustering of voltage-gated sodium channels

14602817


check buttonFusion gene breakpoints across NRCAM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NRCAM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAI401223NRCAMchr7

107788350

+NRCAMchr7

107789159

-
ChiTaRS5.0N/ABF593690NRCAMchr7

107788350

+NRCAMchr7

107789159

-


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Fusion Gene ORF analysis for NRCAM-NRCAM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000351718ENST00000351718NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000351718ENST00000379024NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000351718ENST00000379028NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000351718ENST00000413765NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000379022ENST00000351718NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000379022ENST00000379024NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000379022ENST00000379028NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000379022ENST00000413765NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000379024ENST00000351718NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000379024ENST00000379024NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000379024ENST00000379028NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000379024ENST00000413765NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000379028ENST00000351718NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000379028ENST00000379024NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000379028ENST00000379028NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000379028ENST00000413765NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000413765ENST00000351718NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000413765ENST00000379024NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000413765ENST00000379028NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000413765ENST00000413765NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000425651ENST00000351718NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000425651ENST00000379024NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000425651ENST00000379028NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000425651ENST00000413765NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000522550ENST00000351718NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000522550ENST00000379024NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000522550ENST00000379028NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-3UTRENST00000522550ENST00000413765NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-5UTRENST00000351718ENST00000522550NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-5UTRENST00000379022ENST00000522550NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-5UTRENST00000379024ENST00000522550NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-5UTRENST00000379028ENST00000522550NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-5UTRENST00000413765ENST00000522550NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-5UTRENST00000425651ENST00000522550NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-5UTRENST00000522550ENST00000522550NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000351718ENST00000379022NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000351718ENST00000425651NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000379022ENST00000379022NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000379022ENST00000425651NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000379024ENST00000379022NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000379024ENST00000425651NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000379028ENST00000379022NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000379028ENST00000425651NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000413765ENST00000379022NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000413765ENST00000425651NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000425651ENST00000379022NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000425651ENST00000425651NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000522550ENST00000379022NRCAMchr7

107788350

+NRCAMchr7

107789159

-
intron-intronENST00000522550ENST00000425651NRCAMchr7

107788350

+NRCAMchr7

107789159

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NRCAM-NRCAM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NRCAM-NRCAM


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:107788350/:107789159)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NRCAM

Q92823

NRCAM

Q92823

FUNCTION: Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. {ECO:0000250|UniProtKB:Q810U4}.FUNCTION: Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. {ECO:0000250|UniProtKB:Q810U4}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NRCAM-NRCAM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NRCAM-NRCAM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NRCAM-NRCAM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NRCAM-NRCAM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource