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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NREP-COMMD10 (FusionGDB2 ID:60250)

Fusion Gene Summary for NREP-COMMD10

check button Fusion gene summary
Fusion gene informationFusion gene name: NREP-COMMD10
Fusion gene ID: 60250
HgeneTgene
Gene symbol

NREP

COMMD10

Gene ID

9315

51397

Gene nameneuronal regeneration related proteinCOMM domain containing 10
SynonymsC5orf13|D4S114|P311|PRO1873|PTZ17|SEZ17PTD002
Cytomap

5q22.1

5q23.1

Type of geneprotein-codingprotein-coding
Descriptionneuronal regeneration-related proteinneuronal protein 3.1neuronal regeneration related protein homologprotein p311COMM domain-containing protein 10
Modification date2020031320200313
UniProtAcc

Q16612

Q9Y6G5

Ensembl transtripts involved in fusion geneENST00000257435, ENST00000379671, 
ENST00000419114, ENST00000446294, 
ENST00000447165, ENST00000450761, 
ENST00000453526, ENST00000455559, 
ENST00000508870, ENST00000509025, 
ENST00000509427, ENST00000509979, 
ENST00000515855, ENST00000395634, 
ENST00000507742, 		ENST00000503424, 
ENST00000274458, ENST00000515539, 
Fusion gene scores* DoF score4 X 4 X 2=3214 X 11 X 6=924
# samples 414
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(14/924*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NREP [Title/Abstract] AND COMMD10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNREP(111091467)-COMMD10(115469765), # samples:1
Anticipated loss of major functional domain due to fusion event.NREP-COMMD10 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NREP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across COMMD10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-A3-3376-01ANREPchr5

111091467

-COMMD10chr5

115469765

+


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Fusion Gene ORF analysis for NREP-COMMD10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000257435ENST00000503424NREPchr5

111091467

-COMMD10chr5

115469765

+
5CDS-intronENST00000379671ENST00000503424NREPchr5

111091467

-COMMD10chr5

115469765

+
5CDS-intronENST00000419114ENST00000503424NREPchr5

111091467

-COMMD10chr5

115469765

+
5CDS-intronENST00000446294ENST00000503424NREPchr5

111091467

-COMMD10chr5

115469765

+
5CDS-intronENST00000447165ENST00000503424NREPchr5

111091467

-COMMD10chr5

115469765

+
5CDS-intronENST00000450761ENST00000503424NREPchr5

111091467

-COMMD10chr5

115469765

+
5CDS-intronENST00000453526ENST00000503424NREPchr5

111091467

-COMMD10chr5

115469765

+
5CDS-intronENST00000455559ENST00000503424NREPchr5

111091467

-COMMD10chr5

115469765

+
5CDS-intronENST00000508870ENST00000503424NREPchr5

111091467

-COMMD10chr5

115469765

+
5CDS-intronENST00000509025ENST00000503424NREPchr5

111091467

-COMMD10chr5

115469765

+
5CDS-intronENST00000509427ENST00000503424NREPchr5

111091467

-COMMD10chr5

115469765

+
5CDS-intronENST00000509979ENST00000503424NREPchr5

111091467

-COMMD10chr5

115469765

+
5CDS-intronENST00000515855ENST00000503424NREPchr5

111091467

-COMMD10chr5

115469765

+
Frame-shiftENST00000379671ENST00000274458NREPchr5

111091467

-COMMD10chr5

115469765

+
Frame-shiftENST00000379671ENST00000515539NREPchr5

111091467

-COMMD10chr5

115469765

+
Frame-shiftENST00000446294ENST00000274458NREPchr5

111091467

-COMMD10chr5

115469765

+
Frame-shiftENST00000446294ENST00000515539NREPchr5

111091467

-COMMD10chr5

115469765

+
Frame-shiftENST00000450761ENST00000274458NREPchr5

111091467

-COMMD10chr5

115469765

+
Frame-shiftENST00000450761ENST00000515539NREPchr5

111091467

-COMMD10chr5

115469765

+
Frame-shiftENST00000453526ENST00000274458NREPchr5

111091467

-COMMD10chr5

115469765

+
Frame-shiftENST00000453526ENST00000515539NREPchr5

111091467

-COMMD10chr5

115469765

+
Frame-shiftENST00000508870ENST00000274458NREPchr5

111091467

-COMMD10chr5

115469765

+
Frame-shiftENST00000508870ENST00000515539NREPchr5

111091467

-COMMD10chr5

115469765

+
Frame-shiftENST00000509427ENST00000274458NREPchr5

111091467

-COMMD10chr5

115469765

+
Frame-shiftENST00000509427ENST00000515539NREPchr5

111091467

-COMMD10chr5

115469765

+
Frame-shiftENST00000509979ENST00000274458NREPchr5

111091467

-COMMD10chr5

115469765

+
Frame-shiftENST00000509979ENST00000515539NREPchr5

111091467

-COMMD10chr5

115469765

+
In-frameENST00000257435ENST00000274458NREPchr5

111091467

-COMMD10chr5

115469765

+
In-frameENST00000257435ENST00000515539NREPchr5

111091467

-COMMD10chr5

115469765

+
In-frameENST00000419114ENST00000274458NREPchr5

111091467

-COMMD10chr5

115469765

+
In-frameENST00000419114ENST00000515539NREPchr5

111091467

-COMMD10chr5

115469765

+
In-frameENST00000447165ENST00000274458NREPchr5

111091467

-COMMD10chr5

115469765

+
In-frameENST00000447165ENST00000515539NREPchr5

111091467

-COMMD10chr5

115469765

+
In-frameENST00000455559ENST00000274458NREPchr5

111091467

-COMMD10chr5

115469765

+
In-frameENST00000455559ENST00000515539NREPchr5

111091467

-COMMD10chr5

115469765

+
In-frameENST00000509025ENST00000274458NREPchr5

111091467

-COMMD10chr5

115469765

+
In-frameENST00000509025ENST00000515539NREPchr5

111091467

-COMMD10chr5

115469765

+
In-frameENST00000515855ENST00000274458NREPchr5

111091467

-COMMD10chr5

115469765

+
In-frameENST00000515855ENST00000515539NREPchr5

111091467

-COMMD10chr5

115469765

+
intron-3CDSENST00000395634ENST00000274458NREPchr5

111091467

-COMMD10chr5

115469765

+
intron-3CDSENST00000395634ENST00000515539NREPchr5

111091467

-COMMD10chr5

115469765

+
intron-3CDSENST00000507742ENST00000274458NREPchr5

111091467

-COMMD10chr5

115469765

+
intron-3CDSENST00000507742ENST00000515539NREPchr5

111091467

-COMMD10chr5

115469765

+
intron-intronENST00000395634ENST00000503424NREPchr5

111091467

-COMMD10chr5

115469765

+
intron-intronENST00000507742ENST00000503424NREPchr5

111091467

-COMMD10chr5

115469765

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000509025NREPchr5111091467-ENST00000274458COMMD10chr5115469765+1128120866549105
ENST00000509025NREPchr5111091467-ENST00000515539COMMD10chr5115469765+49812011732970
ENST00000257435NREPchr5111091467-ENST00000274458COMMD10chr5115469765+1192184930613105
ENST00000257435NREPchr5111091467-ENST00000515539COMMD10chr5115469765+56218418139370
ENST00000447165NREPchr5111091467-ENST00000274458COMMD10chr5115469765+14904821228911105
ENST00000447165NREPchr5111091467-ENST00000515539COMMD10chr5115469765+86048247969170
ENST00000515855NREPchr5111091467-ENST00000274458COMMD10chr5115469765+1128120866549105
ENST00000515855NREPchr5111091467-ENST00000515539COMMD10chr5115469765+49812011732970
ENST00000419114NREPchr5111091467-ENST00000274458COMMD10chr5115469765+12912831029712105
ENST00000419114NREPchr5111091467-ENST00000515539COMMD10chr5115469765+66128328049270
ENST00000455559NREPchr5111091467-ENST00000274458COMMD10chr5115469765+13873793740125
ENST00000455559NREPchr5111091467-ENST00000515539COMMD10chr5115469765+7573793740125

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000509025ENST00000274458NREPchr5111091467-COMMD10chr5115469765+0.270370750.7296292
ENST00000509025ENST00000515539NREPchr5111091467-COMMD10chr5115469765+0.100346120.89965385
ENST00000257435ENST00000274458NREPchr5111091467-COMMD10chr5115469765+0.291061550.7089385
ENST00000257435ENST00000515539NREPchr5111091467-COMMD10chr5115469765+0.0610400550.93895996
ENST00000447165ENST00000274458NREPchr5111091467-COMMD10chr5115469765+0.183361070.8166389
ENST00000447165ENST00000515539NREPchr5111091467-COMMD10chr5115469765+0.066280710.9337193
ENST00000515855ENST00000274458NREPchr5111091467-COMMD10chr5115469765+0.270370750.7296292
ENST00000515855ENST00000515539NREPchr5111091467-COMMD10chr5115469765+0.100346120.89965385
ENST00000419114ENST00000274458NREPchr5111091467-COMMD10chr5115469765+0.52317820.4768218
ENST00000419114ENST00000515539NREPchr5111091467-COMMD10chr5115469765+0.197202250.80279773
ENST00000455559ENST00000274458NREPchr5111091467-COMMD10chr5115469765+0.33174650.6682535
ENST00000455559ENST00000515539NREPchr5111091467-COMMD10chr5115469765+0.10850040.8914996

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Fusion Genomic Features for NREP-COMMD10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NREPchr5111091466-COMMD10chr5115469764+0.65542880.34457114
NREPchr5111091466-COMMD10chr5115469764+0.65542880.34457114

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NREP-COMMD10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:111091467/chr5:115469765)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NREP

Q16612

COMMD10

Q9Y6G5

FUNCTION: May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation. {ECO:0000250, ECO:0000269|PubMed:11358844, ECO:0000269|PubMed:16229809}.FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). {ECO:0000269|PubMed:15799966, ECO:0000305|PubMed:21778237}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCOMMD10chr5:111091467chr5:115469765ENST0000027445837133_202133203.0DomainCOMM

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NREP-COMMD10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>60250_60250_1_NREP-COMMD10_NREP_chr5_111091467_ENST00000257435_COMMD10_chr5_115469765_ENST00000274458_length(transcript)=1192nt_BP=184nt
CTCCCTCCCCCAATCCCCCCTCCCCCCCCAATCTGTCTTTCTAGCATGTTGCCCTTTTTCAACCACATTTGTGTTTCAGGTGTAGAGAGG
AGAGAGAGTGAACAGGGAGCGGGGCTTTTGTCTGTTGGTCTCCCTGGACTGAAGAGAGGGAGAATAGAAGCCCAAGACTAAGATTCTCAA
AATGCTAGAGACCGTTGGATGGCAGCTTAACCTTCAGATGGCTCACTCTGCTCAAGCAAAACTAAAATCTCCTCAAGCTGTGTTACAACT
CGGAGTGAACAATGAAGATTCAAAGAGCCTGGAGAAAGTTCTTGTGGAATTCAGTCACAAGGAGTTGTTTGATTTCTATAACAAGCTAGA
GACTATACAAGCACAGCTGGATTCCCTTACATGATGTTTTCGAAGACTGTTTTTTTCATCACGCTCCTGCCACCTCATTATTTTGCATTG
AAGATACATTGCCAGGTTGTGTTTTCTGAAGGATTCAGTGACTTGCTTTCTGTAAATTATATGGCTTATCACTTCTTAGACAAATAACAA
CCAATAGAGATCATTGTTAAGAATACTGAGGTTCTAATATACTTTCTTTAGTTCTGTGAGCCAACAGTAATTATTAAGAACACTTTCCCT
TTAAAGGAAACAAAAGTGAATACCATATTGTTTTTACTGTCATAGTGTTGCTTTCTTGCCTGTCCTGCTTAGTTTTTACTTGCTGGATGA
TACCATAATGTATCAAGGAGCGTCCATGGATACAAGATAAGATGTGTACCTTAGTAGAATACAGAGCTTTGGTAATTACATGAATAAAAT
TAAGAAAATAGCCATATACAATCAAATACACTATGGCATTTTTATTTGAATATGATGAGTATATTTTGCTTCGGAAATAATATAGGAAGG
AAATGTAAAATAGTGAGTAGTATGGTATCAGTTAATTCCAGTCTGAGCTTCTCTGTCAACTTCAGTTTCTCTCTCAGTTTAATGATTTAA
TAATAGTCCAGGTTTTTGTGTGTTTTTCTTTATACTGCAAATTAATAATGATTCACTTTATAGTTTGGGAGACAGAATCAGGTCTTGAAT
AAAATAATTGTAATGAGTGCTAAATGGGCACCATTATTCGAATCAGATACCTTTTATATTCTCTTTCCATAAATACGTTGATTTCTGTCA

>60250_60250_1_NREP-COMMD10_NREP_chr5_111091467_ENST00000257435_COMMD10_chr5_115469765_ENST00000274458_length(amino acids)=105AA_BP=
MIPYYSLFYISFLYYFRSKIYSSYSNKNAIVYLIVYGYFLNFIHVITKALYSTKVHILSCIHGRSLIHYGIIQQVKTKQDRQESNTMTVK

--------------------------------------------------------------
>60250_60250_2_NREP-COMMD10_NREP_chr5_111091467_ENST00000257435_COMMD10_chr5_115469765_ENST00000515539_length(transcript)=562nt_BP=184nt
CTCCCTCCCCCAATCCCCCCTCCCCCCCCAATCTGTCTTTCTAGCATGTTGCCCTTTTTCAACCACATTTGTGTTTCAGGTGTAGAGAGG
AGAGAGAGTGAACAGGGAGCGGGGCTTTTGTCTGTTGGTCTCCCTGGACTGAAGAGAGGGAGAATAGAAGCCCAAGACTAAGATTCTCAA
AATGCTAGAGACCGTTGGATGGCAGCTTAACCTTCAGATGGCTCACTCTGCTCAAGCAAAACTAAAATCTCCTCAAGCTGTGTTACAACT
CGGAGTGAACAATGAAGATTCAAAGAGCCTGGAGAAAGTTCTTGTGGAATTCAGTCACAAGGAGTTGTTTGATTTCTATAACAAGCTAGA
GACTATACAAGCACAGCTGGATTCCCTTACATGATGTTTTCGAAGACTGTTTTTTTCATCACGCTCCTGCCACCTCATTATTTTGCATTG
AAGATACATTGCCAGGTTGTGTTTTCTGAAGGATTCAGTGACTTGCTTTCTGTAAATTATATGGCTTATCACTTCTTAGACAAATAACAA

>60250_60250_2_NREP-COMMD10_NREP_chr5_111091467_ENST00000257435_COMMD10_chr5_115469765_ENST00000515539_length(amino acids)=70AA_BP=1

--------------------------------------------------------------
>60250_60250_3_NREP-COMMD10_NREP_chr5_111091467_ENST00000419114_COMMD10_chr5_115469765_ENST00000274458_length(transcript)=1291nt_BP=283nt
AGTCTGGCTCCTAGGCGGCTGCACAGTGGCAGCAAGGCTGGGGCGCTGGCTCCGCGCCAGCTCCATCAGAATTAGCTCATTGTTCACTAG
CACCCTAGCGGGAGAGAGAGGGAAAGGGAGAGAGAGAGACTCTTAGAGAAAGAGAGAGACACACACACTCTTGGAGAGAGAGCGCGAGGT
GTAGAGAGGAGAGAGAGTGAACAGGGAGCGGGGCTTTTGTCTGTTGGTCTCCCTGGACTGAAGAGAGGGAGAATAGAAGCCCAAGACTAA
GATTCTCAAAATGCTAGAGACCGTTGGATGGCAGCTTAACCTTCAGATGGCTCACTCTGCTCAAGCAAAACTAAAATCTCCTCAAGCTGT
GTTACAACTCGGAGTGAACAATGAAGATTCAAAGAGCCTGGAGAAAGTTCTTGTGGAATTCAGTCACAAGGAGTTGTTTGATTTCTATAA
CAAGCTAGAGACTATACAAGCACAGCTGGATTCCCTTACATGATGTTTTCGAAGACTGTTTTTTTCATCACGCTCCTGCCACCTCATTAT
TTTGCATTGAAGATACATTGCCAGGTTGTGTTTTCTGAAGGATTCAGTGACTTGCTTTCTGTAAATTATATGGCTTATCACTTCTTAGAC
AAATAACAACCAATAGAGATCATTGTTAAGAATACTGAGGTTCTAATATACTTTCTTTAGTTCTGTGAGCCAACAGTAATTATTAAGAAC
ACTTTCCCTTTAAAGGAAACAAAAGTGAATACCATATTGTTTTTACTGTCATAGTGTTGCTTTCTTGCCTGTCCTGCTTAGTTTTTACTT
GCTGGATGATACCATAATGTATCAAGGAGCGTCCATGGATACAAGATAAGATGTGTACCTTAGTAGAATACAGAGCTTTGGTAATTACAT
GAATAAAATTAAGAAAATAGCCATATACAATCAAATACACTATGGCATTTTTATTTGAATATGATGAGTATATTTTGCTTCGGAAATAAT
ATAGGAAGGAAATGTAAAATAGTGAGTAGTATGGTATCAGTTAATTCCAGTCTGAGCTTCTCTGTCAACTTCAGTTTCTCTCTCAGTTTA
ATGATTTAATAATAGTCCAGGTTTTTGTGTGTTTTTCTTTATACTGCAAATTAATAATGATTCACTTTATAGTTTGGGAGACAGAATCAG
GTCTTGAATAAAATAATTGTAATGAGTGCTAAATGGGCACCATTATTCGAATCAGATACCTTTTATATTCTCTTTCCATAAATACGTTGA

>60250_60250_3_NREP-COMMD10_NREP_chr5_111091467_ENST00000419114_COMMD10_chr5_115469765_ENST00000274458_length(amino acids)=105AA_BP=
MIPYYSLFYISFLYYFRSKIYSSYSNKNAIVYLIVYGYFLNFIHVITKALYSTKVHILSCIHGRSLIHYGIIQQVKTKQDRQESNTMTVK

--------------------------------------------------------------
>60250_60250_4_NREP-COMMD10_NREP_chr5_111091467_ENST00000419114_COMMD10_chr5_115469765_ENST00000515539_length(transcript)=661nt_BP=283nt
AGTCTGGCTCCTAGGCGGCTGCACAGTGGCAGCAAGGCTGGGGCGCTGGCTCCGCGCCAGCTCCATCAGAATTAGCTCATTGTTCACTAG
CACCCTAGCGGGAGAGAGAGGGAAAGGGAGAGAGAGAGACTCTTAGAGAAAGAGAGAGACACACACACTCTTGGAGAGAGAGCGCGAGGT
GTAGAGAGGAGAGAGAGTGAACAGGGAGCGGGGCTTTTGTCTGTTGGTCTCCCTGGACTGAAGAGAGGGAGAATAGAAGCCCAAGACTAA
GATTCTCAAAATGCTAGAGACCGTTGGATGGCAGCTTAACCTTCAGATGGCTCACTCTGCTCAAGCAAAACTAAAATCTCCTCAAGCTGT
GTTACAACTCGGAGTGAACAATGAAGATTCAAAGAGCCTGGAGAAAGTTCTTGTGGAATTCAGTCACAAGGAGTTGTTTGATTTCTATAA
CAAGCTAGAGACTATACAAGCACAGCTGGATTCCCTTACATGATGTTTTCGAAGACTGTTTTTTTCATCACGCTCCTGCCACCTCATTAT
TTTGCATTGAAGATACATTGCCAGGTTGTGTTTTCTGAAGGATTCAGTGACTTGCTTTCTGTAAATTATATGGCTTATCACTTCTTAGAC

>60250_60250_4_NREP-COMMD10_NREP_chr5_111091467_ENST00000419114_COMMD10_chr5_115469765_ENST00000515539_length(amino acids)=70AA_BP=1

--------------------------------------------------------------
>60250_60250_5_NREP-COMMD10_NREP_chr5_111091467_ENST00000447165_COMMD10_chr5_115469765_ENST00000274458_length(transcript)=1490nt_BP=482nt
ACTCTGAGGCATTACACTACACGGTGGAAGGCTGATTCCTATTCTGTCGTCTTGATTGCAAATATACTGCCAGTAGTATGTCTGGGAACA
AAGAGCAGCCAGAAAACAATCTATTTTTATCACTTGGTTCTACTTTTAAGTTGCTAAACCTTTTGAACTCATGCAATTTAAAGATGAACC
AAACACTAAGAATAGCCCAGGACTCTGCAAAGCCAAGTACCAGGGATTCCTTTGTCCCTTAGTTAAGCCTATAGGCCACTTGGAAAGCTC
TTTCAGAAATCCCAGTAGTTAACAATAATTTGCATGTAACTTATCTTAACCACAGAAAATGGTTATTCGTCTGTAACCTCTAAAGAGGCA
TTTTTCGTTTGCTGACCTGTGGTGAGGCGATGTGTCTACTGTATTTAAACATATTTTGCAGGTTGGTCTCCCTGGACTGAAGAGAGGGAG
AATAGAAGCCCAAGACTAAGATTCTCAAAATGCTAGAGACCGTTGGATGGCAGCTTAACCTTCAGATGGCTCACTCTGCTCAAGCAAAAC
TAAAATCTCCTCAAGCTGTGTTACAACTCGGAGTGAACAATGAAGATTCAAAGAGCCTGGAGAAAGTTCTTGTGGAATTCAGTCACAAGG
AGTTGTTTGATTTCTATAACAAGCTAGAGACTATACAAGCACAGCTGGATTCCCTTACATGATGTTTTCGAAGACTGTTTTTTTCATCAC
GCTCCTGCCACCTCATTATTTTGCATTGAAGATACATTGCCAGGTTGTGTTTTCTGAAGGATTCAGTGACTTGCTTTCTGTAAATTATAT
GGCTTATCACTTCTTAGACAAATAACAACCAATAGAGATCATTGTTAAGAATACTGAGGTTCTAATATACTTTCTTTAGTTCTGTGAGCC
AACAGTAATTATTAAGAACACTTTCCCTTTAAAGGAAACAAAAGTGAATACCATATTGTTTTTACTGTCATAGTGTTGCTTTCTTGCCTG
TCCTGCTTAGTTTTTACTTGCTGGATGATACCATAATGTATCAAGGAGCGTCCATGGATACAAGATAAGATGTGTACCTTAGTAGAATAC
AGAGCTTTGGTAATTACATGAATAAAATTAAGAAAATAGCCATATACAATCAAATACACTATGGCATTTTTATTTGAATATGATGAGTAT
ATTTTGCTTCGGAAATAATATAGGAAGGAAATGTAAAATAGTGAGTAGTATGGTATCAGTTAATTCCAGTCTGAGCTTCTCTGTCAACTT
CAGTTTCTCTCTCAGTTTAATGATTTAATAATAGTCCAGGTTTTTGTGTGTTTTTCTTTATACTGCAAATTAATAATGATTCACTTTATA
GTTTGGGAGACAGAATCAGGTCTTGAATAAAATAATTGTAATGAGTGCTAAATGGGCACCATTATTCGAATCAGATACCTTTTATATTCT

>60250_60250_5_NREP-COMMD10_NREP_chr5_111091467_ENST00000447165_COMMD10_chr5_115469765_ENST00000274458_length(amino acids)=105AA_BP=
MIPYYSLFYISFLYYFRSKIYSSYSNKNAIVYLIVYGYFLNFIHVITKALYSTKVHILSCIHGRSLIHYGIIQQVKTKQDRQESNTMTVK

--------------------------------------------------------------
>60250_60250_6_NREP-COMMD10_NREP_chr5_111091467_ENST00000447165_COMMD10_chr5_115469765_ENST00000515539_length(transcript)=860nt_BP=482nt
ACTCTGAGGCATTACACTACACGGTGGAAGGCTGATTCCTATTCTGTCGTCTTGATTGCAAATATACTGCCAGTAGTATGTCTGGGAACA
AAGAGCAGCCAGAAAACAATCTATTTTTATCACTTGGTTCTACTTTTAAGTTGCTAAACCTTTTGAACTCATGCAATTTAAAGATGAACC
AAACACTAAGAATAGCCCAGGACTCTGCAAAGCCAAGTACCAGGGATTCCTTTGTCCCTTAGTTAAGCCTATAGGCCACTTGGAAAGCTC
TTTCAGAAATCCCAGTAGTTAACAATAATTTGCATGTAACTTATCTTAACCACAGAAAATGGTTATTCGTCTGTAACCTCTAAAGAGGCA
TTTTTCGTTTGCTGACCTGTGGTGAGGCGATGTGTCTACTGTATTTAAACATATTTTGCAGGTTGGTCTCCCTGGACTGAAGAGAGGGAG
AATAGAAGCCCAAGACTAAGATTCTCAAAATGCTAGAGACCGTTGGATGGCAGCTTAACCTTCAGATGGCTCACTCTGCTCAAGCAAAAC
TAAAATCTCCTCAAGCTGTGTTACAACTCGGAGTGAACAATGAAGATTCAAAGAGCCTGGAGAAAGTTCTTGTGGAATTCAGTCACAAGG
AGTTGTTTGATTTCTATAACAAGCTAGAGACTATACAAGCACAGCTGGATTCCCTTACATGATGTTTTCGAAGACTGTTTTTTTCATCAC
GCTCCTGCCACCTCATTATTTTGCATTGAAGATACATTGCCAGGTTGTGTTTTCTGAAGGATTCAGTGACTTGCTTTCTGTAAATTATAT

>60250_60250_6_NREP-COMMD10_NREP_chr5_111091467_ENST00000447165_COMMD10_chr5_115469765_ENST00000515539_length(amino acids)=70AA_BP=1

--------------------------------------------------------------
>60250_60250_7_NREP-COMMD10_NREP_chr5_111091467_ENST00000455559_COMMD10_chr5_115469765_ENST00000274458_length(transcript)=1387nt_BP=379nt
ACGCGCAGCCACAGGACCTCTGGGCCCGGCCTTCAGGGGCGCTCCCCGCCCCGGGCTTCCCCGCGGAAGGGAGTGGGGCGCGCGTACCCA
GCTGAGGGGCAGGGTCCGACCCGAGGCCGTGTGCAAATGCATCCTTCGCGGACTCTTTGTGTGTCTGAGCGCGGCTCCGCGCCGCCGCAG
GCACCATTTTCTGCTTCGCTCAGGACAGGCACATAAAAGGAAGGCGGCTGCCGCCCGTCGCCGTCCTCTTTTCCTCAGATGCCCTCTGCT
GCAGGTGTAGAGAGGAGAGAGAGTGAACAGGGAGCGGGGCTTTTGTCTGTTGGTCTCCCTGGACTGAAGAGAGGGAGAATAGAAGCCCAA
GACTAAGATTCTCAAAATGCTAGAGACCGTTGGATGGCAGCTTAACCTTCAGATGGCTCACTCTGCTCAAGCAAAACTAAAATCTCCTCA
AGCTGTGTTACAACTCGGAGTGAACAATGAAGATTCAAAGAGCCTGGAGAAAGTTCTTGTGGAATTCAGTCACAAGGAGTTGTTTGATTT
CTATAACAAGCTAGAGACTATACAAGCACAGCTGGATTCCCTTACATGATGTTTTCGAAGACTGTTTTTTTCATCACGCTCCTGCCACCT
CATTATTTTGCATTGAAGATACATTGCCAGGTTGTGTTTTCTGAAGGATTCAGTGACTTGCTTTCTGTAAATTATATGGCTTATCACTTC
TTAGACAAATAACAACCAATAGAGATCATTGTTAAGAATACTGAGGTTCTAATATACTTTCTTTAGTTCTGTGAGCCAACAGTAATTATT
AAGAACACTTTCCCTTTAAAGGAAACAAAAGTGAATACCATATTGTTTTTACTGTCATAGTGTTGCTTTCTTGCCTGTCCTGCTTAGTTT
TTACTTGCTGGATGATACCATAATGTATCAAGGAGCGTCCATGGATACAAGATAAGATGTGTACCTTAGTAGAATACAGAGCTTTGGTAA
TTACATGAATAAAATTAAGAAAATAGCCATATACAATCAAATACACTATGGCATTTTTATTTGAATATGATGAGTATATTTTGCTTCGGA
AATAATATAGGAAGGAAATGTAAAATAGTGAGTAGTATGGTATCAGTTAATTCCAGTCTGAGCTTCTCTGTCAACTTCAGTTTCTCTCTC
AGTTTAATGATTTAATAATAGTCCAGGTTTTTGTGTGTTTTTCTTTATACTGCAAATTAATAATGATTCACTTTATAGTTTGGGAGACAG
AATCAGGTCTTGAATAAAATAATTGTAATGAGTGCTAAATGGGCACCATTATTCGAATCAGATACCTTTTATATTCTCTTTCCATAAATA

>60250_60250_7_NREP-COMMD10_NREP_chr5_111091467_ENST00000455559_COMMD10_chr5_115469765_ENST00000274458_length(amino acids)=125AA_BP=
MRILVLGFYSPSLQSRETNRQKPRSLFTLSPLYTCSRGHLRKRGRRRAAAAFLLCACPERSRKWCLRRRGAALRHTKSPRRMHLHTASGR

--------------------------------------------------------------
>60250_60250_8_NREP-COMMD10_NREP_chr5_111091467_ENST00000455559_COMMD10_chr5_115469765_ENST00000515539_length(transcript)=757nt_BP=379nt
ACGCGCAGCCACAGGACCTCTGGGCCCGGCCTTCAGGGGCGCTCCCCGCCCCGGGCTTCCCCGCGGAAGGGAGTGGGGCGCGCGTACCCA
GCTGAGGGGCAGGGTCCGACCCGAGGCCGTGTGCAAATGCATCCTTCGCGGACTCTTTGTGTGTCTGAGCGCGGCTCCGCGCCGCCGCAG
GCACCATTTTCTGCTTCGCTCAGGACAGGCACATAAAAGGAAGGCGGCTGCCGCCCGTCGCCGTCCTCTTTTCCTCAGATGCCCTCTGCT
GCAGGTGTAGAGAGGAGAGAGAGTGAACAGGGAGCGGGGCTTTTGTCTGTTGGTCTCCCTGGACTGAAGAGAGGGAGAATAGAAGCCCAA
GACTAAGATTCTCAAAATGCTAGAGACCGTTGGATGGCAGCTTAACCTTCAGATGGCTCACTCTGCTCAAGCAAAACTAAAATCTCCTCA
AGCTGTGTTACAACTCGGAGTGAACAATGAAGATTCAAAGAGCCTGGAGAAAGTTCTTGTGGAATTCAGTCACAAGGAGTTGTTTGATTT
CTATAACAAGCTAGAGACTATACAAGCACAGCTGGATTCCCTTACATGATGTTTTCGAAGACTGTTTTTTTCATCACGCTCCTGCCACCT
CATTATTTTGCATTGAAGATACATTGCCAGGTTGTGTTTTCTGAAGGATTCAGTGACTTGCTTTCTGTAAATTATATGGCTTATCACTTC

>60250_60250_8_NREP-COMMD10_NREP_chr5_111091467_ENST00000455559_COMMD10_chr5_115469765_ENST00000515539_length(amino acids)=125AA_BP=
MRILVLGFYSPSLQSRETNRQKPRSLFTLSPLYTCSRGHLRKRGRRRAAAAFLLCACPERSRKWCLRRRGAALRHTKSPRRMHLHTASGR

--------------------------------------------------------------
>60250_60250_9_NREP-COMMD10_NREP_chr5_111091467_ENST00000509025_COMMD10_chr5_115469765_ENST00000274458_length(transcript)=1128nt_BP=120nt
ACATTTGTGTTTCAGGTGTAGAGAGGAGAGAGAGTGAACAGGGAGCGGGGCTTTTGTCTGTTGGTCTCCCTGGACTGAAGAGAGGGAGAA
TAGAAGCCCAAGACTAAGATTCTCAAAATGCTAGAGACCGTTGGATGGCAGCTTAACCTTCAGATGGCTCACTCTGCTCAAGCAAAACTA
AAATCTCCTCAAGCTGTGTTACAACTCGGAGTGAACAATGAAGATTCAAAGAGCCTGGAGAAAGTTCTTGTGGAATTCAGTCACAAGGAG
TTGTTTGATTTCTATAACAAGCTAGAGACTATACAAGCACAGCTGGATTCCCTTACATGATGTTTTCGAAGACTGTTTTTTTCATCACGC
TCCTGCCACCTCATTATTTTGCATTGAAGATACATTGCCAGGTTGTGTTTTCTGAAGGATTCAGTGACTTGCTTTCTGTAAATTATATGG
CTTATCACTTCTTAGACAAATAACAACCAATAGAGATCATTGTTAAGAATACTGAGGTTCTAATATACTTTCTTTAGTTCTGTGAGCCAA
CAGTAATTATTAAGAACACTTTCCCTTTAAAGGAAACAAAAGTGAATACCATATTGTTTTTACTGTCATAGTGTTGCTTTCTTGCCTGTC
CTGCTTAGTTTTTACTTGCTGGATGATACCATAATGTATCAAGGAGCGTCCATGGATACAAGATAAGATGTGTACCTTAGTAGAATACAG
AGCTTTGGTAATTACATGAATAAAATTAAGAAAATAGCCATATACAATCAAATACACTATGGCATTTTTATTTGAATATGATGAGTATAT
TTTGCTTCGGAAATAATATAGGAAGGAAATGTAAAATAGTGAGTAGTATGGTATCAGTTAATTCCAGTCTGAGCTTCTCTGTCAACTTCA
GTTTCTCTCTCAGTTTAATGATTTAATAATAGTCCAGGTTTTTGTGTGTTTTTCTTTATACTGCAAATTAATAATGATTCACTTTATAGT
TTGGGAGACAGAATCAGGTCTTGAATAAAATAATTGTAATGAGTGCTAAATGGGCACCATTATTCGAATCAGATACCTTTTATATTCTCT

>60250_60250_9_NREP-COMMD10_NREP_chr5_111091467_ENST00000509025_COMMD10_chr5_115469765_ENST00000274458_length(amino acids)=105AA_BP=
MIPYYSLFYISFLYYFRSKIYSSYSNKNAIVYLIVYGYFLNFIHVITKALYSTKVHILSCIHGRSLIHYGIIQQVKTKQDRQESNTMTVK

--------------------------------------------------------------
>60250_60250_10_NREP-COMMD10_NREP_chr5_111091467_ENST00000509025_COMMD10_chr5_115469765_ENST00000515539_length(transcript)=498nt_BP=120nt
ACATTTGTGTTTCAGGTGTAGAGAGGAGAGAGAGTGAACAGGGAGCGGGGCTTTTGTCTGTTGGTCTCCCTGGACTGAAGAGAGGGAGAA
TAGAAGCCCAAGACTAAGATTCTCAAAATGCTAGAGACCGTTGGATGGCAGCTTAACCTTCAGATGGCTCACTCTGCTCAAGCAAAACTA
AAATCTCCTCAAGCTGTGTTACAACTCGGAGTGAACAATGAAGATTCAAAGAGCCTGGAGAAAGTTCTTGTGGAATTCAGTCACAAGGAG
TTGTTTGATTTCTATAACAAGCTAGAGACTATACAAGCACAGCTGGATTCCCTTACATGATGTTTTCGAAGACTGTTTTTTTCATCACGC
TCCTGCCACCTCATTATTTTGCATTGAAGATACATTGCCAGGTTGTGTTTTCTGAAGGATTCAGTGACTTGCTTTCTGTAAATTATATGG

>60250_60250_10_NREP-COMMD10_NREP_chr5_111091467_ENST00000509025_COMMD10_chr5_115469765_ENST00000515539_length(amino acids)=70AA_BP=1

--------------------------------------------------------------
>60250_60250_11_NREP-COMMD10_NREP_chr5_111091467_ENST00000515855_COMMD10_chr5_115469765_ENST00000274458_length(transcript)=1128nt_BP=120nt
ACATTTGTGTTTCAGGTGTAGAGAGGAGAGAGAGTGAACAGGGAGCGGGGCTTTTGTCTGTTGGTCTCCCTGGACTGAAGAGAGGGAGAA
TAGAAGCCCAAGACTAAGATTCTCAAAATGCTAGAGACCGTTGGATGGCAGCTTAACCTTCAGATGGCTCACTCTGCTCAAGCAAAACTA
AAATCTCCTCAAGCTGTGTTACAACTCGGAGTGAACAATGAAGATTCAAAGAGCCTGGAGAAAGTTCTTGTGGAATTCAGTCACAAGGAG
TTGTTTGATTTCTATAACAAGCTAGAGACTATACAAGCACAGCTGGATTCCCTTACATGATGTTTTCGAAGACTGTTTTTTTCATCACGC
TCCTGCCACCTCATTATTTTGCATTGAAGATACATTGCCAGGTTGTGTTTTCTGAAGGATTCAGTGACTTGCTTTCTGTAAATTATATGG
CTTATCACTTCTTAGACAAATAACAACCAATAGAGATCATTGTTAAGAATACTGAGGTTCTAATATACTTTCTTTAGTTCTGTGAGCCAA
CAGTAATTATTAAGAACACTTTCCCTTTAAAGGAAACAAAAGTGAATACCATATTGTTTTTACTGTCATAGTGTTGCTTTCTTGCCTGTC
CTGCTTAGTTTTTACTTGCTGGATGATACCATAATGTATCAAGGAGCGTCCATGGATACAAGATAAGATGTGTACCTTAGTAGAATACAG
AGCTTTGGTAATTACATGAATAAAATTAAGAAAATAGCCATATACAATCAAATACACTATGGCATTTTTATTTGAATATGATGAGTATAT
TTTGCTTCGGAAATAATATAGGAAGGAAATGTAAAATAGTGAGTAGTATGGTATCAGTTAATTCCAGTCTGAGCTTCTCTGTCAACTTCA
GTTTCTCTCTCAGTTTAATGATTTAATAATAGTCCAGGTTTTTGTGTGTTTTTCTTTATACTGCAAATTAATAATGATTCACTTTATAGT
TTGGGAGACAGAATCAGGTCTTGAATAAAATAATTGTAATGAGTGCTAAATGGGCACCATTATTCGAATCAGATACCTTTTATATTCTCT

>60250_60250_11_NREP-COMMD10_NREP_chr5_111091467_ENST00000515855_COMMD10_chr5_115469765_ENST00000274458_length(amino acids)=105AA_BP=
MIPYYSLFYISFLYYFRSKIYSSYSNKNAIVYLIVYGYFLNFIHVITKALYSTKVHILSCIHGRSLIHYGIIQQVKTKQDRQESNTMTVK

--------------------------------------------------------------
>60250_60250_12_NREP-COMMD10_NREP_chr5_111091467_ENST00000515855_COMMD10_chr5_115469765_ENST00000515539_length(transcript)=498nt_BP=120nt
ACATTTGTGTTTCAGGTGTAGAGAGGAGAGAGAGTGAACAGGGAGCGGGGCTTTTGTCTGTTGGTCTCCCTGGACTGAAGAGAGGGAGAA
TAGAAGCCCAAGACTAAGATTCTCAAAATGCTAGAGACCGTTGGATGGCAGCTTAACCTTCAGATGGCTCACTCTGCTCAAGCAAAACTA
AAATCTCCTCAAGCTGTGTTACAACTCGGAGTGAACAATGAAGATTCAAAGAGCCTGGAGAAAGTTCTTGTGGAATTCAGTCACAAGGAG
TTGTTTGATTTCTATAACAAGCTAGAGACTATACAAGCACAGCTGGATTCCCTTACATGATGTTTTCGAAGACTGTTTTTTTCATCACGC
TCCTGCCACCTCATTATTTTGCATTGAAGATACATTGCCAGGTTGTGTTTTCTGAAGGATTCAGTGACTTGCTTTCTGTAAATTATATGG

>60250_60250_12_NREP-COMMD10_NREP_chr5_111091467_ENST00000515855_COMMD10_chr5_115469765_ENST00000515539_length(amino acids)=70AA_BP=1

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NREP-COMMD10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NREP-COMMD10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NREP-COMMD10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource