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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:NRF1-PDIA4 (FusionGDB2 ID:60265) |
Fusion Gene Summary for NRF1-PDIA4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NRF1-PDIA4 | Fusion gene ID: 60265 | Hgene | Tgene | Gene symbol | NRF1 | PDIA4 | Gene ID | 4899 | 9601 |
| Gene name | nuclear respiratory factor 1 | protein disulfide isomerase family A member 4 | |
| Synonyms | ALPHA-PAL | ERP70|ERP72|ERp-72 | |
| Cytomap | 7q32.2 | 7q36.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear respiratory factor 1alpha palindromic-binding protein | protein disulfide-isomerase A4ER protein 70ER protein 72endoplasmic reticulum resident protein 70endoplasmic reticulum resident protein 72protein disulfide isomerase related protein (calcium-binding protein, intestinal-related)protein disulfide isom | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000223190, ENST00000311967, ENST00000353868, ENST00000393230, ENST00000393231, ENST00000393232, ENST00000539636, ENST00000477428, | ENST00000286091, | |
| Fusion gene scores | * DoF score | 14 X 9 X 8=1008 | 5 X 4 X 4=80 |
| # samples | 16 | 5 | |
| ** MAII score | log2(16/1008*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NRF1 [Title/Abstract] AND PDIA4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | NRF1(129367205)-PDIA4(148718239), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across NRF1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across PDIA4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PRAD | TCGA-EJ-A8FU-01A | NRF1 | chr7 | 129367205 | + | PDIA4 | chr7 | 148718239 | - |
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Fusion Gene ORF analysis for NRF1-PDIA4 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000223190 | ENST00000286091 | NRF1 | chr7 | 129367205 | + | PDIA4 | chr7 | 148718239 | - |
| In-frame | ENST00000311967 | ENST00000286091 | NRF1 | chr7 | 129367205 | + | PDIA4 | chr7 | 148718239 | - |
| In-frame | ENST00000353868 | ENST00000286091 | NRF1 | chr7 | 129367205 | + | PDIA4 | chr7 | 148718239 | - |
| In-frame | ENST00000393230 | ENST00000286091 | NRF1 | chr7 | 129367205 | + | PDIA4 | chr7 | 148718239 | - |
| In-frame | ENST00000393231 | ENST00000286091 | NRF1 | chr7 | 129367205 | + | PDIA4 | chr7 | 148718239 | - |
| In-frame | ENST00000393232 | ENST00000286091 | NRF1 | chr7 | 129367205 | + | PDIA4 | chr7 | 148718239 | - |
| In-frame | ENST00000539636 | ENST00000286091 | NRF1 | chr7 | 129367205 | + | PDIA4 | chr7 | 148718239 | - |
| intron-3CDS | ENST00000477428 | ENST00000286091 | NRF1 | chr7 | 129367205 | + | PDIA4 | chr7 | 148718239 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000393232 | NRF1 | chr7 | 129367205 | + | ENST00000286091 | PDIA4 | chr7 | 148718239 | - | 4047 | 1465 | 117 | 3314 | 1065 |
| ENST00000353868 | NRF1 | chr7 | 129367205 | + | ENST00000286091 | PDIA4 | chr7 | 148718239 | - | 3849 | 1267 | 117 | 3116 | 999 |
| ENST00000539636 | NRF1 | chr7 | 129367205 | + | ENST00000286091 | PDIA4 | chr7 | 148718239 | - | 3910 | 1328 | 433 | 3177 | 914 |
| ENST00000311967 | NRF1 | chr7 | 129367205 | + | ENST00000286091 | PDIA4 | chr7 | 148718239 | - | 4008 | 1426 | 78 | 3275 | 1065 |
| ENST00000223190 | NRF1 | chr7 | 129367205 | + | ENST00000286091 | PDIA4 | chr7 | 148718239 | - | 4008 | 1426 | 78 | 3275 | 1065 |
| ENST00000393230 | NRF1 | chr7 | 129367205 | + | ENST00000286091 | PDIA4 | chr7 | 148718239 | - | 4040 | 1458 | 110 | 3307 | 1065 |
| ENST00000393231 | NRF1 | chr7 | 129367205 | + | ENST00000286091 | PDIA4 | chr7 | 148718239 | - | 3931 | 1349 | 1 | 3198 | 1065 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000393232 | ENST00000286091 | NRF1 | chr7 | 129367205 | + | PDIA4 | chr7 | 148718239 | - | 0.001433511 | 0.99856657 |
| ENST00000353868 | ENST00000286091 | NRF1 | chr7 | 129367205 | + | PDIA4 | chr7 | 148718239 | - | 0.002129941 | 0.9978701 |
| ENST00000539636 | ENST00000286091 | NRF1 | chr7 | 129367205 | + | PDIA4 | chr7 | 148718239 | - | 0.001321521 | 0.9986785 |
| ENST00000311967 | ENST00000286091 | NRF1 | chr7 | 129367205 | + | PDIA4 | chr7 | 148718239 | - | 0.001261734 | 0.9987382 |
| ENST00000223190 | ENST00000286091 | NRF1 | chr7 | 129367205 | + | PDIA4 | chr7 | 148718239 | - | 0.001261734 | 0.9987382 |
| ENST00000393230 | ENST00000286091 | NRF1 | chr7 | 129367205 | + | PDIA4 | chr7 | 148718239 | - | 0.001035158 | 0.9989648 |
| ENST00000393231 | ENST00000286091 | NRF1 | chr7 | 129367205 | + | PDIA4 | chr7 | 148718239 | - | 0.00103408 | 0.998966 |
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Fusion Genomic Features for NRF1-PDIA4 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for NRF1-PDIA4 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:129367205/chr7:148718239) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NRF1 | chr7:129367205 | chr7:148718239 | ENST00000223190 | + | 10 | 11 | 41_66 | 449 | 504.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | NRF1 | chr7:129367205 | chr7:148718239 | ENST00000223190 | + | 10 | 11 | 80_86 | 449 | 504.0 | Compositional bias | Note=Poly-Ala |
| Hgene | NRF1 | chr7:129367205 | chr7:148718239 | ENST00000353868 | + | 9 | 10 | 41_66 | 383 | 438.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | NRF1 | chr7:129367205 | chr7:148718239 | ENST00000353868 | + | 9 | 10 | 80_86 | 383 | 438.0 | Compositional bias | Note=Poly-Ala |
| Hgene | NRF1 | chr7:129367205 | chr7:148718239 | ENST00000393230 | + | 10 | 11 | 41_66 | 449 | 504.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | NRF1 | chr7:129367205 | chr7:148718239 | ENST00000393230 | + | 10 | 11 | 80_86 | 449 | 504.0 | Compositional bias | Note=Poly-Ala |
| Hgene | NRF1 | chr7:129367205 | chr7:148718239 | ENST00000393232 | + | 10 | 11 | 41_66 | 449 | 504.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | NRF1 | chr7:129367205 | chr7:148718239 | ENST00000393232 | + | 10 | 11 | 80_86 | 449 | 504.0 | Compositional bias | Note=Poly-Ala |
| Hgene | NRF1 | chr7:129367205 | chr7:148718239 | ENST00000223190 | + | 10 | 11 | 109_305 | 449 | 504.0 | DNA binding | . |
| Hgene | NRF1 | chr7:129367205 | chr7:148718239 | ENST00000353868 | + | 9 | 10 | 109_305 | 383 | 438.0 | DNA binding | . |
| Hgene | NRF1 | chr7:129367205 | chr7:148718239 | ENST00000393230 | + | 10 | 11 | 109_305 | 449 | 504.0 | DNA binding | . |
| Hgene | NRF1 | chr7:129367205 | chr7:148718239 | ENST00000393232 | + | 10 | 11 | 109_305 | 449 | 504.0 | DNA binding | . |
| Hgene | NRF1 | chr7:129367205 | chr7:148718239 | ENST00000223190 | + | 10 | 11 | 88_116 | 449 | 504.0 | Motif | Note=Nuclear localization signal |
| Hgene | NRF1 | chr7:129367205 | chr7:148718239 | ENST00000353868 | + | 9 | 10 | 88_116 | 383 | 438.0 | Motif | Note=Nuclear localization signal |
| Hgene | NRF1 | chr7:129367205 | chr7:148718239 | ENST00000393230 | + | 10 | 11 | 88_116 | 449 | 504.0 | Motif | Note=Nuclear localization signal |
| Hgene | NRF1 | chr7:129367205 | chr7:148718239 | ENST00000393232 | + | 10 | 11 | 88_116 | 449 | 504.0 | Motif | Note=Nuclear localization signal |
| Hgene | NRF1 | chr7:129367205 | chr7:148718239 | ENST00000223190 | + | 10 | 11 | 1_78 | 449 | 504.0 | Region | Note=Dimerization |
| Hgene | NRF1 | chr7:129367205 | chr7:148718239 | ENST00000353868 | + | 9 | 10 | 1_78 | 383 | 438.0 | Region | Note=Dimerization |
| Hgene | NRF1 | chr7:129367205 | chr7:148718239 | ENST00000393230 | + | 10 | 11 | 1_78 | 449 | 504.0 | Region | Note=Dimerization |
| Hgene | NRF1 | chr7:129367205 | chr7:148718239 | ENST00000393232 | + | 10 | 11 | 1_78 | 449 | 504.0 | Region | Note=Dimerization |
| Tgene | PDIA4 | chr7:129367205 | chr7:148718239 | ENST00000286091 | 0 | 10 | 39_55 | 29 | 646.0 | Compositional bias | Note=Asp/Glu-rich (acidic) | |
| Tgene | PDIA4 | chr7:129367205 | chr7:148718239 | ENST00000286091 | 0 | 10 | 158_301 | 29 | 646.0 | Domain | Thioredoxin 2 | |
| Tgene | PDIA4 | chr7:129367205 | chr7:148718239 | ENST00000286091 | 0 | 10 | 505_636 | 29 | 646.0 | Domain | Thioredoxin 3 | |
| Tgene | PDIA4 | chr7:129367205 | chr7:148718239 | ENST00000286091 | 0 | 10 | 642_645 | 29 | 646.0 | Motif | Note=Prevents secretion from ER |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NRF1 | chr7:129367205 | chr7:148718239 | ENST00000223190 | + | 10 | 11 | 301_476 | 449 | 504.0 | Region | Note=Required for transcriptional activation |
| Hgene | NRF1 | chr7:129367205 | chr7:148718239 | ENST00000353868 | + | 9 | 10 | 301_476 | 383 | 438.0 | Region | Note=Required for transcriptional activation |
| Hgene | NRF1 | chr7:129367205 | chr7:148718239 | ENST00000393230 | + | 10 | 11 | 301_476 | 449 | 504.0 | Region | Note=Required for transcriptional activation |
| Hgene | NRF1 | chr7:129367205 | chr7:148718239 | ENST00000393232 | + | 10 | 11 | 301_476 | 449 | 504.0 | Region | Note=Required for transcriptional activation |
| Tgene | PDIA4 | chr7:129367205 | chr7:148718239 | ENST00000286091 | 0 | 10 | 21_169 | 29 | 646.0 | Domain | Thioredoxin 1 |
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Fusion Gene Sequence for NRF1-PDIA4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >60265_60265_1_NRF1-PDIA4_NRF1_chr7_129367205_ENST00000223190_PDIA4_chr7_148718239_ENST00000286091_length(transcript)=4008nt_BP=1426nt GAGGCTGCGAGGAGCCGGCGCGGTCGCAGTCTCCACGGCGCAGGCCCACGGTAGCGCAGCCGCTCTGAGTAGAACTTCATGGAGGAACAC GGAGTGACCCAAACCGAACATATGGCTACCATAGAAGCACATGCAGTGGCCCAGCAAGTGCAGCAGGTCCATGTGGCTACTTACACCGAG CATAGTATGCTGAGTGCTGATGAAGACTCGCCTTCTTCTCCCGAGGACACCTCTTACGATGACTCAGATATACTCAACTCCACAGCAGCT GATGAGGTGACAGCTCATCTGGCAGCTGCAGGTCCTGTGGGAATGGCCGCTGCTGCTGCTGTGGCAACAGGAAAGAAACGGAAACGGCCT CATGTATTTGAGTCTAATCCATCTATCCGGAAGAGGCAACAAACACGTTTGCTTCGGAAACTTCGAGCCACGTTAGATGAATATACTACT CGTGTGGGACAGCAAGCTATTGTCCTCTGTATCTCACCCTCCAAACCTAACCCTGTCTTTAAAGTGTTTGGTGCAGCACCTTTGGAGAAT GTGGTGCGTAAGTACAAGAGCATGATCCTGGAAGACCTGGAGTCTGCTCTGGCAGAACACGCCCCTGCGCCACAGGAGGTTAACTCAGAA CTGCCGCCTCTCACCATCGACGGAATTCCAGTCTCTGTGGACAAAATGACCCAGGCCCAGCTTCGGGCATTTATCCCAGAGATGCTCAAG TACTCTACAGGTCGGGGAAAACCAGGCTGGGGGAAAGAAAGCTGCAAGCCCATCTGGTGGCCTGAAGATATCCCCTGGGCAAATGTCCGG AGTGATGTCCGCACAGAAGAGCAAAAGCAGAGGGTTTCATGGACCCAGGCACTACGGACCATAGTTAAAAACTGTTATAAACAGCATGGG CGGGAAGACCTTTTGTATGCCTTTGAAGATCAGCAAACGCAAACACAGGCCACAGCCACACATAGTATAGCTCATCTTGTACCATCACAG ACTGTAGTCCAGACTTTTAGTAACCCTGATGGCACTGTCTCACTTATCCAGGTTGGTACGGGGGCAACAGTAGCCACATTGGCTGATGCT TCAGAATTGCCAACCACGGTCACCGTTGCCCAAGTGAATTATTCTGCCGTGGCTGATGGAGAGGTGGAACAAAATTGGGCCACGTTACAG GGAGGTGAGATGACCATCCAGACGACGCAAGCATCAGAGGCCACCCAGGCGGTGGCATCGTTGGCAGAGGCCGCAGTGGCAGCTTCTCAG GAGATGCAGCAGGGAGCTACAGTCACTATGGCGCTTAACAGCGAAGCTGCCGCCCATGCTGTCGCCACCCTGGCTGAGGCCACCTTACAA GGTGGGGGACAGATCGTCTTGTCTGGGGAAACCGCAGCAGCCGTCGGAGCACTTACTGGAGTCCAAGATGCTAATGATTCTTCTAACAGA GAAAATGCCATTGAGGATGAAGAGGAGGAGGAGGAGGAAGATGATGATGAGGAAGAAGACGACTTGGAAGTTAAGGAAGAAAATGGAGTC TTGGTCCTAAATGATGCAAACTTTGATAATTTTGTGGCTGACAAAGACACAGTGCTGCTGGAGTTTTATGCTCCATGGTGTGGACATTGC AAGCAGTTTGCTCCGGAATATGAAAAAATTGCCAACATATTAAAGGATAAAGATCCTCCCATTCCTGTTGCCAAGATCGATGCAACCTCA GCGTCTGTGCTGGCCAGCAGGTTTGATGTGAGTGGCTACCCCACCATCAAGATCCTTAAGAAGGGGCAGGCTGTAGACTACGAGGGCTCC AGAACCCAGGAAGAAATTGTTGCCAAGGTCAGAGAAGTCTCCCAGCCCGACTGGACGCCTCCACCAGAAGTCACGCTTGTGTTGACCAAA GAGAACTTTGATGAAGTTGTGAATGATGCAGATATCATTCTGGTGGAGTTTTATGCCCCATGGTGTGGACACTGCAAGAAACTTGCCCCC GAGTATGAGAAGGCCGCCAAGGAGCTCAGCAAGCGTTCTCCTCCAATTCCCCTGGCAAAGGTCGACGCCACCGCAGAAACAGACCTGGCC AAGAGGTTTGATGTCTCTGGCTATCCCACCCTGAAAATTTTCCGCAAAGGAAGGCCTTATGACTACAACGGCCCACGAGAAAAATATGGA ATCGTTGATTACATGATCGAGCAGTCCGGGCCTCCCTCCAAGGAGATTCTGACCCTGAAGCAGGTCCAGGAGTTCCTGAAGGATGGAGAC GATGTCATCATCATCGGGGTCTTTAAGGGGGAGAGTGACCCAGCCTACCAGCAATACCAGGATGCCGCTAACAACCTGAGAGAAGATTAC AAATTTCACCACACTTTCAGCACAGAAATAGCAAAGTTCTTGAAAGTCTCCCAGGGGCAGTTGGTTGTAATGCAGCCTGAGAAATTCCAG TCCAAGTATGAGCCCCGGAGCCACATGATGGACGTCCAGGGCTCCACCCAGGACTCGGCCATCAAGGACTTCGTGCTGAAGTACGCCCTG CCCCTGGTTGGCCACCGCAAGGTGTCAAACGATGCTAAGCGCTACACCAGGCGCCCCCTGGTGGTCGTCTACTACAGTGTGGACTTCAGC TTTGATTACAGAGCTGCAACTCAGTTTTGGCGGAGCAAAGTCCTAGAGGTGGCCAAGGACTTCCCTGAGTACACCTTTGCCATTGCGGAC GAAGAGGACTATGCTGGGGAGGTGAAGGACCTGGGGCTCAGCGAGAGTGGGGAGGATGTCAATGCCGCCATCCTGGACGAGAGTGGGAAG AAGTTCGCCATGGAGCCAGAGGAGTTTGACTCTGACACCCTCCGCGAGTTTGTCACTGCTTTCAAAAAAGGAAAACTGAAGCCAGTCATC AAATCCCAGCCAGTGCCCAAGAACAACAAGGGACCCGTCAAGGTCGTGGTGGGAAAGACCTTTGACTCCATTGTGATGGACCCCAAGAAG GACGTCCTCATCGAGTTCTACGCGCCATGGTGCGGGCACTGCAAGCAGCTAGAGCCCGTGTACAACAGCCTGGCCAAGAAGTACAAGGGC CAAAAGGGCCTGGTCATCGCCAAGATGGACGCCACTGCCAACGACGTCCCCAGCGACCGCTATAAGGTGGAGGGCTTCCCCACCATCTAC TTCGCCCCCAGTGGGGACAAAAAGAACCCAGTTAAATTTGAGGGTGGAGACAGAGATCTGGAGCATTTGAGCAAGTTTATAGAAGAACAT GCCACAAAACTGAGCAGGACCAAGGAAGAGCTTTGAAGGCCTGAGGTCTGCGGAAGGTGGGAGGAGGCAGACGCCCTGCGTGGCCCATGG TCGGGGCGTCCACGCCGAGGCCGGCAACAAACGACAGTATCTCGGATTCCTTTTTTTTTTTTTTTAATTTTTTATACTTTGGTGTTTCAC TTCATGCTCTGAATACTGAATAACCATGAATGACTGAATAGTTTAGTCCAGATTTTTACAGAGGATACATCTATTTTTATCATTATTTGG GGTTTGAAAAATTTTTTTTTACACCTTCTAATTTCTTTATTTCTCAAAGCAGATAATTCTTCTGTGTGAAAATGTTTTCTTTTTTTAATT TAAGGTTTAAAATTCCTTTTCCAAATCATGTTGATTTTGCTCTTTGCTTTTTCGTTGTCTGAGAAATTGTTGGCGTAGATTTGGCTTCTG GTATGTGTTTCTGATTGCTTCCTGTTGAGCACAAAGTGAGAGCTGCCACTGAGCAGCCCTGCCAGGGGTGCTGTTTCAGGCTGGGCATCG CCAGGCGGCCTCCCTGCAAACCAAGGGCTGGGGGCAAAGGGGCATGATCCAGGGTCCCCCAGGGTGGGCTCAGCTCCAGGGAGAGGCCAC CCACGTGGCAGCCCCACCTCTTGAGAGCCCCCAGTGCCGGAGCAGAAAGGACCCTGGACCCAGAGGCAGATACTGCGGGGTGGTAGAAAA >60265_60265_1_NRF1-PDIA4_NRF1_chr7_129367205_ENST00000223190_PDIA4_chr7_148718239_ENST00000286091_length(amino acids)=1065AA_BP=449 MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSADEDSPSSPEDTSYDDSDILNSTAADEVTAHLAAAGPVGMAAAAAVATGKK RKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLENVVRKYKSMILEDLESALAEHAPAPQE VNSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQRVSWTQALRTIVKNCY KQHGREDLLYAFEDQQTQTQATATHSIAHLVPSQTVVQTFSNPDGTVSLIQVGTGATVATLADASELPTTVTVAQVNYSAVADGEVEQNW ATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQQGATVTMALNSEAAAHAVATLAEATLQGGGQIVLSGETAAAVGALTGVQDAND SSNRENAIEDEEEEEEEDDDEEEDDLEVKEENGVLVLNDANFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKI DATSASVLASRFDVSGYPTIKILKKGQAVDYEGSRTQEEIVAKVREVSQPDWTPPPEVTLVLTKENFDEVVNDADIILVEFYAPWCGHCK KLAPEYEKAAKELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTLKIFRKGRPYDYNGPREKYGIVDYMIEQSGPPSKEILTLKQVQEFL KDGDDVIIIGVFKGESDPAYQQYQDAANNLREDYKFHHTFSTEIAKFLKVSQGQLVVMQPEKFQSKYEPRSHMMDVQGSTQDSAIKDFVL KYALPLVGHRKVSNDAKRYTRRPLVVVYYSVDFSFDYRAATQFWRSKVLEVAKDFPEYTFAIADEEDYAGEVKDLGLSESGEDVNAAILD ESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIKSQPVPKNNKGPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAK -------------------------------------------------------------- >60265_60265_2_NRF1-PDIA4_NRF1_chr7_129367205_ENST00000311967_PDIA4_chr7_148718239_ENST00000286091_length(transcript)=4008nt_BP=1426nt GAGGCTGCGAGGAGCCGGCGCGGTCGCAGTCTCCACGGCGCAGGCCCACGGTAGCGCAGCCGCTCTGAGTAGAACTTCATGGAGGAACAC GGAGTGACCCAAACCGAACATATGGCTACCATAGAAGCACATGCAGTGGCCCAGCAAGTGCAGCAGGTCCATGTGGCTACTTACACCGAG CATAGTATGCTGAGTGCTGATGAAGACTCGCCTTCTTCTCCCGAGGACACCTCTTACGATGACTCAGATATACTCAACTCCACAGCAGCT GATGAGGTGACAGCTCATCTGGCAGCTGCAGGTCCTGTGGGAATGGCCGCTGCTGCTGCTGTGGCAACAGGAAAGAAACGGAAACGGCCT CATGTATTTGAGTCTAATCCATCTATCCGGAAGAGGCAACAAACACGTTTGCTTCGGAAACTTCGAGCCACGTTAGATGAATATACTACT CGTGTGGGACAGCAAGCTATTGTCCTCTGTATCTCACCCTCCAAACCTAACCCTGTCTTTAAAGTGTTTGGTGCAGCACCTTTGGAGAAT GTGGTGCGTAAGTACAAGAGCATGATCCTGGAAGACCTGGAGTCTGCTCTGGCAGAACACGCCCCTGCGCCACAGGAGGTTAACTCAGAA CTGCCGCCTCTCACCATCGACGGAATTCCAGTCTCTGTGGACAAAATGACCCAGGCCCAGCTTCGGGCATTTATCCCAGAGATGCTCAAG TACTCTACAGGTCGGGGAAAACCAGGCTGGGGGAAAGAAAGCTGCAAGCCCATCTGGTGGCCTGAAGATATCCCCTGGGCAAATGTCCGG AGTGATGTCCGCACAGAAGAGCAAAAGCAGAGGGTTTCATGGACCCAGGCACTACGGACCATAGTTAAAAACTGTTATAAACAGCATGGG CGGGAAGACCTTTTGTATGCCTTTGAAGATCAGCAAACGCAAACACAGGCCACAGCCACACATAGTATAGCTCATCTTGTACCATCACAG ACTGTAGTCCAGACTTTTAGTAACCCTGATGGCACTGTCTCACTTATCCAGGTTGGTACGGGGGCAACAGTAGCCACATTGGCTGATGCT TCAGAATTGCCAACCACGGTCACCGTTGCCCAAGTGAATTATTCTGCCGTGGCTGATGGAGAGGTGGAACAAAATTGGGCCACGTTACAG GGAGGTGAGATGACCATCCAGACGACGCAAGCATCAGAGGCCACCCAGGCGGTGGCATCGTTGGCAGAGGCCGCAGTGGCAGCTTCTCAG GAGATGCAGCAGGGAGCTACAGTCACTATGGCGCTTAACAGCGAAGCTGCCGCCCATGCTGTCGCCACCCTGGCTGAGGCCACCTTACAA GGTGGGGGACAGATCGTCTTGTCTGGGGAAACCGCAGCAGCCGTCGGAGCACTTACTGGAGTCCAAGATGCTAATGATTCTTCTAACAGA GAAAATGCCATTGAGGATGAAGAGGAGGAGGAGGAGGAAGATGATGATGAGGAAGAAGACGACTTGGAAGTTAAGGAAGAAAATGGAGTC TTGGTCCTAAATGATGCAAACTTTGATAATTTTGTGGCTGACAAAGACACAGTGCTGCTGGAGTTTTATGCTCCATGGTGTGGACATTGC AAGCAGTTTGCTCCGGAATATGAAAAAATTGCCAACATATTAAAGGATAAAGATCCTCCCATTCCTGTTGCCAAGATCGATGCAACCTCA GCGTCTGTGCTGGCCAGCAGGTTTGATGTGAGTGGCTACCCCACCATCAAGATCCTTAAGAAGGGGCAGGCTGTAGACTACGAGGGCTCC AGAACCCAGGAAGAAATTGTTGCCAAGGTCAGAGAAGTCTCCCAGCCCGACTGGACGCCTCCACCAGAAGTCACGCTTGTGTTGACCAAA GAGAACTTTGATGAAGTTGTGAATGATGCAGATATCATTCTGGTGGAGTTTTATGCCCCATGGTGTGGACACTGCAAGAAACTTGCCCCC GAGTATGAGAAGGCCGCCAAGGAGCTCAGCAAGCGTTCTCCTCCAATTCCCCTGGCAAAGGTCGACGCCACCGCAGAAACAGACCTGGCC AAGAGGTTTGATGTCTCTGGCTATCCCACCCTGAAAATTTTCCGCAAAGGAAGGCCTTATGACTACAACGGCCCACGAGAAAAATATGGA ATCGTTGATTACATGATCGAGCAGTCCGGGCCTCCCTCCAAGGAGATTCTGACCCTGAAGCAGGTCCAGGAGTTCCTGAAGGATGGAGAC GATGTCATCATCATCGGGGTCTTTAAGGGGGAGAGTGACCCAGCCTACCAGCAATACCAGGATGCCGCTAACAACCTGAGAGAAGATTAC AAATTTCACCACACTTTCAGCACAGAAATAGCAAAGTTCTTGAAAGTCTCCCAGGGGCAGTTGGTTGTAATGCAGCCTGAGAAATTCCAG TCCAAGTATGAGCCCCGGAGCCACATGATGGACGTCCAGGGCTCCACCCAGGACTCGGCCATCAAGGACTTCGTGCTGAAGTACGCCCTG CCCCTGGTTGGCCACCGCAAGGTGTCAAACGATGCTAAGCGCTACACCAGGCGCCCCCTGGTGGTCGTCTACTACAGTGTGGACTTCAGC TTTGATTACAGAGCTGCAACTCAGTTTTGGCGGAGCAAAGTCCTAGAGGTGGCCAAGGACTTCCCTGAGTACACCTTTGCCATTGCGGAC GAAGAGGACTATGCTGGGGAGGTGAAGGACCTGGGGCTCAGCGAGAGTGGGGAGGATGTCAATGCCGCCATCCTGGACGAGAGTGGGAAG AAGTTCGCCATGGAGCCAGAGGAGTTTGACTCTGACACCCTCCGCGAGTTTGTCACTGCTTTCAAAAAAGGAAAACTGAAGCCAGTCATC AAATCCCAGCCAGTGCCCAAGAACAACAAGGGACCCGTCAAGGTCGTGGTGGGAAAGACCTTTGACTCCATTGTGATGGACCCCAAGAAG GACGTCCTCATCGAGTTCTACGCGCCATGGTGCGGGCACTGCAAGCAGCTAGAGCCCGTGTACAACAGCCTGGCCAAGAAGTACAAGGGC CAAAAGGGCCTGGTCATCGCCAAGATGGACGCCACTGCCAACGACGTCCCCAGCGACCGCTATAAGGTGGAGGGCTTCCCCACCATCTAC TTCGCCCCCAGTGGGGACAAAAAGAACCCAGTTAAATTTGAGGGTGGAGACAGAGATCTGGAGCATTTGAGCAAGTTTATAGAAGAACAT GCCACAAAACTGAGCAGGACCAAGGAAGAGCTTTGAAGGCCTGAGGTCTGCGGAAGGTGGGAGGAGGCAGACGCCCTGCGTGGCCCATGG TCGGGGCGTCCACGCCGAGGCCGGCAACAAACGACAGTATCTCGGATTCCTTTTTTTTTTTTTTTAATTTTTTATACTTTGGTGTTTCAC TTCATGCTCTGAATACTGAATAACCATGAATGACTGAATAGTTTAGTCCAGATTTTTACAGAGGATACATCTATTTTTATCATTATTTGG GGTTTGAAAAATTTTTTTTTACACCTTCTAATTTCTTTATTTCTCAAAGCAGATAATTCTTCTGTGTGAAAATGTTTTCTTTTTTTAATT TAAGGTTTAAAATTCCTTTTCCAAATCATGTTGATTTTGCTCTTTGCTTTTTCGTTGTCTGAGAAATTGTTGGCGTAGATTTGGCTTCTG GTATGTGTTTCTGATTGCTTCCTGTTGAGCACAAAGTGAGAGCTGCCACTGAGCAGCCCTGCCAGGGGTGCTGTTTCAGGCTGGGCATCG CCAGGCGGCCTCCCTGCAAACCAAGGGCTGGGGGCAAAGGGGCATGATCCAGGGTCCCCCAGGGTGGGCTCAGCTCCAGGGAGAGGCCAC CCACGTGGCAGCCCCACCTCTTGAGAGCCCCCAGTGCCGGAGCAGAAAGGACCCTGGACCCAGAGGCAGATACTGCGGGGTGGTAGAAAA >60265_60265_2_NRF1-PDIA4_NRF1_chr7_129367205_ENST00000311967_PDIA4_chr7_148718239_ENST00000286091_length(amino acids)=1065AA_BP=449 MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSADEDSPSSPEDTSYDDSDILNSTAADEVTAHLAAAGPVGMAAAAAVATGKK RKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLENVVRKYKSMILEDLESALAEHAPAPQE VNSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQRVSWTQALRTIVKNCY KQHGREDLLYAFEDQQTQTQATATHSIAHLVPSQTVVQTFSNPDGTVSLIQVGTGATVATLADASELPTTVTVAQVNYSAVADGEVEQNW ATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQQGATVTMALNSEAAAHAVATLAEATLQGGGQIVLSGETAAAVGALTGVQDAND SSNRENAIEDEEEEEEEDDDEEEDDLEVKEENGVLVLNDANFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKI DATSASVLASRFDVSGYPTIKILKKGQAVDYEGSRTQEEIVAKVREVSQPDWTPPPEVTLVLTKENFDEVVNDADIILVEFYAPWCGHCK KLAPEYEKAAKELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTLKIFRKGRPYDYNGPREKYGIVDYMIEQSGPPSKEILTLKQVQEFL KDGDDVIIIGVFKGESDPAYQQYQDAANNLREDYKFHHTFSTEIAKFLKVSQGQLVVMQPEKFQSKYEPRSHMMDVQGSTQDSAIKDFVL KYALPLVGHRKVSNDAKRYTRRPLVVVYYSVDFSFDYRAATQFWRSKVLEVAKDFPEYTFAIADEEDYAGEVKDLGLSESGEDVNAAILD ESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIKSQPVPKNNKGPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAK -------------------------------------------------------------- >60265_60265_3_NRF1-PDIA4_NRF1_chr7_129367205_ENST00000353868_PDIA4_chr7_148718239_ENST00000286091_length(transcript)=3849nt_BP=1267nt GGCGGCAGAAGCGGCAGCGCTCGCCATTGCCGCTGGTGGCAGGAGGCTGCGAGGAGCCGGCGCGGTCGCAGTCTCCACGGCGCAGGCCCA CGGTAGCGCAGCCGCTCTGAGAACTTCATGGAGGAACACGGAGTGACCCAAACCGAACATATGGCTACCATAGAAGCACATGCAGTGGCC CAGCAAGTGCAGCAGGTCCATGTGGCTACTTACACCGAGCATAGTATGCTGAGTGCTGATGAAGACTCGCCTTCTTCTCCCGAGGACACC TCTTACGATGACTCAGATATACTCAACTCCACAGCAGCTGATGAGGTGACAGCTCATCTGGCAGCTGCAGGTCCTGTGGGAATGGCCGCT GCTGCTGCTGTGGCAACAGGAAAGAAACGGAAACGGCCTCATGTATTTGAGTCTAATCCATCTATCCGGAAGAGGCAACAAACACGTTTG CTTCGGAAACTTCGAGCCACGTTAGATGAATATACTACTCGTGTGGGACAGCAAGCTATTGTCCTCTGTATCTCACCCTCCAAACCTAAC CCTGTCTTTAAAGTGTTTGGTGCAGCACCTTTGGAGAATGTGGTGCGTAAGTACAAGAGCATGATCCTGGAAGACCTGGAGTCTGCTCTG GCAGAACACGCCCCTGCGCCACAGGAGGTTAACTCAGAACTGCCGCCTCTCACCATCGACGGAATTCCAGTCTCTGTGGACAAAATGACC CAGGCCCAGCTTCGGGCATTTATCCCAGAGATGCTCAAGTACTCTACAGGTCGGGGAAAACCAGGCTGGGGGAAAGAAAGCTGCAAGCCC ATCTGGTGGCCTGAAGATATCCCCTGGGCAAATGTCCGGAGTGATGTCCGCACAGAAGAGCAAAAGCAGAGGGTTGGTACGGGGGCAACA GTAGCCACATTGGCTGATGCTTCAGAATTGCCAACCACGGTCACCGTTGCCCAAGTGAATTATTCTGCCGTGGCTGATGGAGAGGTGGAA CAAAATTGGGCCACGTTACAGGGAGGTGAGATGACCATCCAGACGACGCAAGCATCAGAGGCCACCCAGGCGGTGGCATCGTTGGCAGAG GCCGCAGTGGCAGCTTCTCAGGAGATGCAGCAGGGAGCTACAGTCACTATGGCGCTTAACAGCGAAGCTGCCGCCCATGCTGTCGCCACC CTGGCTGAGGCCACCTTACAAGGTGGGGGACAGATCGTCTTGTCTGGGGAAACCGCAGCAGCCGTCGGAGCACTTACTGGAGTCCAAGAT GCTAATGATTCTTCTAACAGAGAAAATGCCATTGAGGATGAAGAGGAGGAGGAGGAGGAAGATGATGATGAGGAAGAAGACGACTTGGAA GTTAAGGAAGAAAATGGAGTCTTGGTCCTAAATGATGCAAACTTTGATAATTTTGTGGCTGACAAAGACACAGTGCTGCTGGAGTTTTAT GCTCCATGGTGTGGACATTGCAAGCAGTTTGCTCCGGAATATGAAAAAATTGCCAACATATTAAAGGATAAAGATCCTCCCATTCCTGTT GCCAAGATCGATGCAACCTCAGCGTCTGTGCTGGCCAGCAGGTTTGATGTGAGTGGCTACCCCACCATCAAGATCCTTAAGAAGGGGCAG GCTGTAGACTACGAGGGCTCCAGAACCCAGGAAGAAATTGTTGCCAAGGTCAGAGAAGTCTCCCAGCCCGACTGGACGCCTCCACCAGAA GTCACGCTTGTGTTGACCAAAGAGAACTTTGATGAAGTTGTGAATGATGCAGATATCATTCTGGTGGAGTTTTATGCCCCATGGTGTGGA CACTGCAAGAAACTTGCCCCCGAGTATGAGAAGGCCGCCAAGGAGCTCAGCAAGCGTTCTCCTCCAATTCCCCTGGCAAAGGTCGACGCC ACCGCAGAAACAGACCTGGCCAAGAGGTTTGATGTCTCTGGCTATCCCACCCTGAAAATTTTCCGCAAAGGAAGGCCTTATGACTACAAC GGCCCACGAGAAAAATATGGAATCGTTGATTACATGATCGAGCAGTCCGGGCCTCCCTCCAAGGAGATTCTGACCCTGAAGCAGGTCCAG GAGTTCCTGAAGGATGGAGACGATGTCATCATCATCGGGGTCTTTAAGGGGGAGAGTGACCCAGCCTACCAGCAATACCAGGATGCCGCT AACAACCTGAGAGAAGATTACAAATTTCACCACACTTTCAGCACAGAAATAGCAAAGTTCTTGAAAGTCTCCCAGGGGCAGTTGGTTGTA ATGCAGCCTGAGAAATTCCAGTCCAAGTATGAGCCCCGGAGCCACATGATGGACGTCCAGGGCTCCACCCAGGACTCGGCCATCAAGGAC TTCGTGCTGAAGTACGCCCTGCCCCTGGTTGGCCACCGCAAGGTGTCAAACGATGCTAAGCGCTACACCAGGCGCCCCCTGGTGGTCGTC TACTACAGTGTGGACTTCAGCTTTGATTACAGAGCTGCAACTCAGTTTTGGCGGAGCAAAGTCCTAGAGGTGGCCAAGGACTTCCCTGAG TACACCTTTGCCATTGCGGACGAAGAGGACTATGCTGGGGAGGTGAAGGACCTGGGGCTCAGCGAGAGTGGGGAGGATGTCAATGCCGCC ATCCTGGACGAGAGTGGGAAGAAGTTCGCCATGGAGCCAGAGGAGTTTGACTCTGACACCCTCCGCGAGTTTGTCACTGCTTTCAAAAAA GGAAAACTGAAGCCAGTCATCAAATCCCAGCCAGTGCCCAAGAACAACAAGGGACCCGTCAAGGTCGTGGTGGGAAAGACCTTTGACTCC ATTGTGATGGACCCCAAGAAGGACGTCCTCATCGAGTTCTACGCGCCATGGTGCGGGCACTGCAAGCAGCTAGAGCCCGTGTACAACAGC CTGGCCAAGAAGTACAAGGGCCAAAAGGGCCTGGTCATCGCCAAGATGGACGCCACTGCCAACGACGTCCCCAGCGACCGCTATAAGGTG GAGGGCTTCCCCACCATCTACTTCGCCCCCAGTGGGGACAAAAAGAACCCAGTTAAATTTGAGGGTGGAGACAGAGATCTGGAGCATTTG AGCAAGTTTATAGAAGAACATGCCACAAAACTGAGCAGGACCAAGGAAGAGCTTTGAAGGCCTGAGGTCTGCGGAAGGTGGGAGGAGGCA GACGCCCTGCGTGGCCCATGGTCGGGGCGTCCACGCCGAGGCCGGCAACAAACGACAGTATCTCGGATTCCTTTTTTTTTTTTTTTAATT TTTTATACTTTGGTGTTTCACTTCATGCTCTGAATACTGAATAACCATGAATGACTGAATAGTTTAGTCCAGATTTTTACAGAGGATACA TCTATTTTTATCATTATTTGGGGTTTGAAAAATTTTTTTTTACACCTTCTAATTTCTTTATTTCTCAAAGCAGATAATTCTTCTGTGTGA AAATGTTTTCTTTTTTTAATTTAAGGTTTAAAATTCCTTTTCCAAATCATGTTGATTTTGCTCTTTGCTTTTTCGTTGTCTGAGAAATTG TTGGCGTAGATTTGGCTTCTGGTATGTGTTTCTGATTGCTTCCTGTTGAGCACAAAGTGAGAGCTGCCACTGAGCAGCCCTGCCAGGGGT GCTGTTTCAGGCTGGGCATCGCCAGGCGGCCTCCCTGCAAACCAAGGGCTGGGGGCAAAGGGGCATGATCCAGGGTCCCCCAGGGTGGGC TCAGCTCCAGGGAGAGGCCACCCACGTGGCAGCCCCACCTCTTGAGAGCCCCCAGTGCCGGAGCAGAAAGGACCCTGGACCCAGAGGCAG >60265_60265_3_NRF1-PDIA4_NRF1_chr7_129367205_ENST00000353868_PDIA4_chr7_148718239_ENST00000286091_length(amino acids)=999AA_BP=383 MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSADEDSPSSPEDTSYDDSDILNSTAADEVTAHLAAAGPVGMAAAAAVATGKK RKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLENVVRKYKSMILEDLESALAEHAPAPQE VNSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQRVGTGATVATLADASE LPTTVTVAQVNYSAVADGEVEQNWATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQQGATVTMALNSEAAAHAVATLAEATLQGG GQIVLSGETAAAVGALTGVQDANDSSNRENAIEDEEEEEEEDDDEEEDDLEVKEENGVLVLNDANFDNFVADKDTVLLEFYAPWCGHCKQ FAPEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVSGYPTIKILKKGQAVDYEGSRTQEEIVAKVREVSQPDWTPPPEVTLVLTKEN FDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTLKIFRKGRPYDYNGPREKYGIV DYMIEQSGPPSKEILTLKQVQEFLKDGDDVIIIGVFKGESDPAYQQYQDAANNLREDYKFHHTFSTEIAKFLKVSQGQLVVMQPEKFQSK YEPRSHMMDVQGSTQDSAIKDFVLKYALPLVGHRKVSNDAKRYTRRPLVVVYYSVDFSFDYRAATQFWRSKVLEVAKDFPEYTFAIADEE DYAGEVKDLGLSESGEDVNAAILDESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIKSQPVPKNNKGPVKVVVGKTFDSIVMDPKKDV LIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDLEHLSKFIEEHAT -------------------------------------------------------------- >60265_60265_4_NRF1-PDIA4_NRF1_chr7_129367205_ENST00000393230_PDIA4_chr7_148718239_ENST00000286091_length(transcript)=4040nt_BP=1458nt CCCCTTTCAGTTCCTGGTCCAGAACTTTACACAGAAAAGGTGCTCAAAGGATATTTGTTTAATGAATGTGGTATGCTGACATTTAAACAG GACAAAACTTGTAGAACTTCATGGAGGAACACGGAGTGACCCAAACCGAACATATGGCTACCATAGAAGCACATGCAGTGGCCCAGCAAG TGCAGCAGGTCCATGTGGCTACTTACACCGAGCATAGTATGCTGAGTGCTGATGAAGACTCGCCTTCTTCTCCCGAGGACACCTCTTACG ATGACTCAGATATACTCAACTCCACAGCAGCTGATGAGGTGACAGCTCATCTGGCAGCTGCAGGTCCTGTGGGAATGGCCGCTGCTGCTG CTGTGGCAACAGGAAAGAAACGGAAACGGCCTCATGTATTTGAGTCTAATCCATCTATCCGGAAGAGGCAACAAACACGTTTGCTTCGGA AACTTCGAGCCACGTTAGATGAATATACTACTCGTGTGGGACAGCAAGCTATTGTCCTCTGTATCTCACCCTCCAAACCTAACCCTGTCT TTAAAGTGTTTGGTGCAGCACCTTTGGAGAATGTGGTGCGTAAGTACAAGAGCATGATCCTGGAAGACCTGGAGTCTGCTCTGGCAGAAC ACGCCCCTGCGCCACAGGAGGTTAACTCAGAACTGCCGCCTCTCACCATCGACGGAATTCCAGTCTCTGTGGACAAAATGACCCAGGCCC AGCTTCGGGCATTTATCCCAGAGATGCTCAAGTACTCTACAGGTCGGGGAAAACCAGGCTGGGGGAAAGAAAGCTGCAAGCCCATCTGGT GGCCTGAAGATATCCCCTGGGCAAATGTCCGGAGTGATGTCCGCACAGAAGAGCAAAAGCAGAGGGTTTCATGGACCCAGGCACTACGGA CCATAGTTAAAAACTGTTATAAACAGCATGGGCGGGAAGACCTTTTGTATGCCTTTGAAGATCAGCAAACGCAAACACAGGCCACAGCCA CACATAGTATAGCTCATCTTGTACCATCACAGACTGTAGTCCAGACTTTTAGTAACCCTGATGGCACTGTCTCACTTATCCAGGTTGGTA CGGGGGCAACAGTAGCCACATTGGCTGATGCTTCAGAATTGCCAACCACGGTCACCGTTGCCCAAGTGAATTATTCTGCCGTGGCTGATG GAGAGGTGGAACAAAATTGGGCCACGTTACAGGGAGGTGAGATGACCATCCAGACGACGCAAGCATCAGAGGCCACCCAGGCGGTGGCAT CGTTGGCAGAGGCCGCAGTGGCAGCTTCTCAGGAGATGCAGCAGGGAGCTACAGTCACTATGGCGCTTAACAGCGAAGCTGCCGCCCATG CTGTCGCCACCCTGGCTGAGGCCACCTTACAAGGTGGGGGACAGATCGTCTTGTCTGGGGAAACCGCAGCAGCCGTCGGAGCACTTACTG GAGTCCAAGATGCTAATGATTCTTCTAACAGAGAAAATGCCATTGAGGATGAAGAGGAGGAGGAGGAGGAAGATGATGATGAGGAAGAAG ACGACTTGGAAGTTAAGGAAGAAAATGGAGTCTTGGTCCTAAATGATGCAAACTTTGATAATTTTGTGGCTGACAAAGACACAGTGCTGC TGGAGTTTTATGCTCCATGGTGTGGACATTGCAAGCAGTTTGCTCCGGAATATGAAAAAATTGCCAACATATTAAAGGATAAAGATCCTC CCATTCCTGTTGCCAAGATCGATGCAACCTCAGCGTCTGTGCTGGCCAGCAGGTTTGATGTGAGTGGCTACCCCACCATCAAGATCCTTA AGAAGGGGCAGGCTGTAGACTACGAGGGCTCCAGAACCCAGGAAGAAATTGTTGCCAAGGTCAGAGAAGTCTCCCAGCCCGACTGGACGC CTCCACCAGAAGTCACGCTTGTGTTGACCAAAGAGAACTTTGATGAAGTTGTGAATGATGCAGATATCATTCTGGTGGAGTTTTATGCCC CATGGTGTGGACACTGCAAGAAACTTGCCCCCGAGTATGAGAAGGCCGCCAAGGAGCTCAGCAAGCGTTCTCCTCCAATTCCCCTGGCAA AGGTCGACGCCACCGCAGAAACAGACCTGGCCAAGAGGTTTGATGTCTCTGGCTATCCCACCCTGAAAATTTTCCGCAAAGGAAGGCCTT ATGACTACAACGGCCCACGAGAAAAATATGGAATCGTTGATTACATGATCGAGCAGTCCGGGCCTCCCTCCAAGGAGATTCTGACCCTGA AGCAGGTCCAGGAGTTCCTGAAGGATGGAGACGATGTCATCATCATCGGGGTCTTTAAGGGGGAGAGTGACCCAGCCTACCAGCAATACC AGGATGCCGCTAACAACCTGAGAGAAGATTACAAATTTCACCACACTTTCAGCACAGAAATAGCAAAGTTCTTGAAAGTCTCCCAGGGGC AGTTGGTTGTAATGCAGCCTGAGAAATTCCAGTCCAAGTATGAGCCCCGGAGCCACATGATGGACGTCCAGGGCTCCACCCAGGACTCGG CCATCAAGGACTTCGTGCTGAAGTACGCCCTGCCCCTGGTTGGCCACCGCAAGGTGTCAAACGATGCTAAGCGCTACACCAGGCGCCCCC TGGTGGTCGTCTACTACAGTGTGGACTTCAGCTTTGATTACAGAGCTGCAACTCAGTTTTGGCGGAGCAAAGTCCTAGAGGTGGCCAAGG ACTTCCCTGAGTACACCTTTGCCATTGCGGACGAAGAGGACTATGCTGGGGAGGTGAAGGACCTGGGGCTCAGCGAGAGTGGGGAGGATG TCAATGCCGCCATCCTGGACGAGAGTGGGAAGAAGTTCGCCATGGAGCCAGAGGAGTTTGACTCTGACACCCTCCGCGAGTTTGTCACTG CTTTCAAAAAAGGAAAACTGAAGCCAGTCATCAAATCCCAGCCAGTGCCCAAGAACAACAAGGGACCCGTCAAGGTCGTGGTGGGAAAGA CCTTTGACTCCATTGTGATGGACCCCAAGAAGGACGTCCTCATCGAGTTCTACGCGCCATGGTGCGGGCACTGCAAGCAGCTAGAGCCCG TGTACAACAGCCTGGCCAAGAAGTACAAGGGCCAAAAGGGCCTGGTCATCGCCAAGATGGACGCCACTGCCAACGACGTCCCCAGCGACC GCTATAAGGTGGAGGGCTTCCCCACCATCTACTTCGCCCCCAGTGGGGACAAAAAGAACCCAGTTAAATTTGAGGGTGGAGACAGAGATC TGGAGCATTTGAGCAAGTTTATAGAAGAACATGCCACAAAACTGAGCAGGACCAAGGAAGAGCTTTGAAGGCCTGAGGTCTGCGGAAGGT GGGAGGAGGCAGACGCCCTGCGTGGCCCATGGTCGGGGCGTCCACGCCGAGGCCGGCAACAAACGACAGTATCTCGGATTCCTTTTTTTT TTTTTTTAATTTTTTATACTTTGGTGTTTCACTTCATGCTCTGAATACTGAATAACCATGAATGACTGAATAGTTTAGTCCAGATTTTTA CAGAGGATACATCTATTTTTATCATTATTTGGGGTTTGAAAAATTTTTTTTTACACCTTCTAATTTCTTTATTTCTCAAAGCAGATAATT CTTCTGTGTGAAAATGTTTTCTTTTTTTAATTTAAGGTTTAAAATTCCTTTTCCAAATCATGTTGATTTTGCTCTTTGCTTTTTCGTTGT CTGAGAAATTGTTGGCGTAGATTTGGCTTCTGGTATGTGTTTCTGATTGCTTCCTGTTGAGCACAAAGTGAGAGCTGCCACTGAGCAGCC CTGCCAGGGGTGCTGTTTCAGGCTGGGCATCGCCAGGCGGCCTCCCTGCAAACCAAGGGCTGGGGGCAAAGGGGCATGATCCAGGGTCCC CCAGGGTGGGCTCAGCTCCAGGGAGAGGCCACCCACGTGGCAGCCCCACCTCTTGAGAGCCCCCAGTGCCGGAGCAGAAAGGACCCTGGA >60265_60265_4_NRF1-PDIA4_NRF1_chr7_129367205_ENST00000393230_PDIA4_chr7_148718239_ENST00000286091_length(amino acids)=1065AA_BP=449 MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSADEDSPSSPEDTSYDDSDILNSTAADEVTAHLAAAGPVGMAAAAAVATGKK RKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLENVVRKYKSMILEDLESALAEHAPAPQE VNSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQRVSWTQALRTIVKNCY KQHGREDLLYAFEDQQTQTQATATHSIAHLVPSQTVVQTFSNPDGTVSLIQVGTGATVATLADASELPTTVTVAQVNYSAVADGEVEQNW ATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQQGATVTMALNSEAAAHAVATLAEATLQGGGQIVLSGETAAAVGALTGVQDAND SSNRENAIEDEEEEEEEDDDEEEDDLEVKEENGVLVLNDANFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKI DATSASVLASRFDVSGYPTIKILKKGQAVDYEGSRTQEEIVAKVREVSQPDWTPPPEVTLVLTKENFDEVVNDADIILVEFYAPWCGHCK KLAPEYEKAAKELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTLKIFRKGRPYDYNGPREKYGIVDYMIEQSGPPSKEILTLKQVQEFL KDGDDVIIIGVFKGESDPAYQQYQDAANNLREDYKFHHTFSTEIAKFLKVSQGQLVVMQPEKFQSKYEPRSHMMDVQGSTQDSAIKDFVL KYALPLVGHRKVSNDAKRYTRRPLVVVYYSVDFSFDYRAATQFWRSKVLEVAKDFPEYTFAIADEEDYAGEVKDLGLSESGEDVNAAILD ESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIKSQPVPKNNKGPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAK -------------------------------------------------------------- >60265_60265_5_NRF1-PDIA4_NRF1_chr7_129367205_ENST00000393231_PDIA4_chr7_148718239_ENST00000286091_length(transcript)=3931nt_BP=1349nt CATGGAGGAACACGGAGTGACCCAAACCGAACATATGGCTACCATAGAAGCACATGCAGTGGCCCAGCAAGTGCAGCAGGTCCATGTGGC TACTTACACCGAGCATAGTATGCTGAGTGCTGATGAAGACTCGCCTTCTTCTCCCGAGGACACCTCTTACGATGACTCAGATATACTCAA CTCCACAGCAGCTGATGAGGTGACAGCTCATCTGGCAGCTGCAGGTCCTGTGGGAATGGCCGCTGCTGCTGCTGTGGCAACAGGAAAGAA ACGGAAACGGCCTCATGTATTTGAGTCTAATCCATCTATCCGGAAGAGGCAACAAACACGTTTGCTTCGGAAACTTCGAGCCACGTTAGA TGAATATACTACTCGTGTGGGACAGCAAGCTATTGTCCTCTGTATCTCACCCTCCAAACCTAACCCTGTCTTTAAAGTGTTTGGTGCAGC ACCTTTGGAGAATGTGGTGCGTAAGTACAAGAGCATGATCCTGGAAGACCTGGAGTCTGCTCTGGCAGAACACGCCCCTGCGCCACAGGA GGTTAACTCAGAACTGCCGCCTCTCACCATCGACGGAATTCCAGTCTCTGTGGACAAAATGACCCAGGCCCAGCTTCGGGCATTTATCCC AGAGATGCTCAAGTACTCTACAGGTCGGGGAAAACCAGGCTGGGGGAAAGAAAGCTGCAAGCCCATCTGGTGGCCTGAAGATATCCCCTG GGCAAATGTCCGGAGTGATGTCCGCACAGAAGAGCAAAAGCAGAGGGTTTCATGGACCCAGGCACTACGGACCATAGTTAAAAACTGTTA TAAACAGCATGGGCGGGAAGACCTTTTGTATGCCTTTGAAGATCAGCAAACGCAAACACAGGCCACAGCCACACATAGTATAGCTCATCT TGTACCATCACAGACTGTAGTCCAGACTTTTAGTAACCCTGATGGCACTGTCTCACTTATCCAGGTTGGTACGGGGGCAACAGTAGCCAC ATTGGCTGATGCTTCAGAATTGCCAACCACGGTCACCGTTGCCCAAGTGAATTATTCTGCCGTGGCTGATGGAGAGGTGGAACAAAATTG GGCCACGTTACAGGGAGGTGAGATGACCATCCAGACGACGCAAGCATCAGAGGCCACCCAGGCGGTGGCATCGTTGGCAGAGGCCGCAGT GGCAGCTTCTCAGGAGATGCAGCAGGGAGCTACAGTCACTATGGCGCTTAACAGCGAAGCTGCCGCCCATGCTGTCGCCACCCTGGCTGA GGCCACCTTACAAGGTGGGGGACAGATCGTCTTGTCTGGGGAAACCGCAGCAGCCGTCGGAGCACTTACTGGAGTCCAAGATGCTAATGA TTCTTCTAACAGAGAAAATGCCATTGAGGATGAAGAGGAGGAGGAGGAGGAAGATGATGATGAGGAAGAAGACGACTTGGAAGTTAAGGA AGAAAATGGAGTCTTGGTCCTAAATGATGCAAACTTTGATAATTTTGTGGCTGACAAAGACACAGTGCTGCTGGAGTTTTATGCTCCATG GTGTGGACATTGCAAGCAGTTTGCTCCGGAATATGAAAAAATTGCCAACATATTAAAGGATAAAGATCCTCCCATTCCTGTTGCCAAGAT CGATGCAACCTCAGCGTCTGTGCTGGCCAGCAGGTTTGATGTGAGTGGCTACCCCACCATCAAGATCCTTAAGAAGGGGCAGGCTGTAGA CTACGAGGGCTCCAGAACCCAGGAAGAAATTGTTGCCAAGGTCAGAGAAGTCTCCCAGCCCGACTGGACGCCTCCACCAGAAGTCACGCT TGTGTTGACCAAAGAGAACTTTGATGAAGTTGTGAATGATGCAGATATCATTCTGGTGGAGTTTTATGCCCCATGGTGTGGACACTGCAA GAAACTTGCCCCCGAGTATGAGAAGGCCGCCAAGGAGCTCAGCAAGCGTTCTCCTCCAATTCCCCTGGCAAAGGTCGACGCCACCGCAGA AACAGACCTGGCCAAGAGGTTTGATGTCTCTGGCTATCCCACCCTGAAAATTTTCCGCAAAGGAAGGCCTTATGACTACAACGGCCCACG AGAAAAATATGGAATCGTTGATTACATGATCGAGCAGTCCGGGCCTCCCTCCAAGGAGATTCTGACCCTGAAGCAGGTCCAGGAGTTCCT GAAGGATGGAGACGATGTCATCATCATCGGGGTCTTTAAGGGGGAGAGTGACCCAGCCTACCAGCAATACCAGGATGCCGCTAACAACCT GAGAGAAGATTACAAATTTCACCACACTTTCAGCACAGAAATAGCAAAGTTCTTGAAAGTCTCCCAGGGGCAGTTGGTTGTAATGCAGCC TGAGAAATTCCAGTCCAAGTATGAGCCCCGGAGCCACATGATGGACGTCCAGGGCTCCACCCAGGACTCGGCCATCAAGGACTTCGTGCT GAAGTACGCCCTGCCCCTGGTTGGCCACCGCAAGGTGTCAAACGATGCTAAGCGCTACACCAGGCGCCCCCTGGTGGTCGTCTACTACAG TGTGGACTTCAGCTTTGATTACAGAGCTGCAACTCAGTTTTGGCGGAGCAAAGTCCTAGAGGTGGCCAAGGACTTCCCTGAGTACACCTT TGCCATTGCGGACGAAGAGGACTATGCTGGGGAGGTGAAGGACCTGGGGCTCAGCGAGAGTGGGGAGGATGTCAATGCCGCCATCCTGGA CGAGAGTGGGAAGAAGTTCGCCATGGAGCCAGAGGAGTTTGACTCTGACACCCTCCGCGAGTTTGTCACTGCTTTCAAAAAAGGAAAACT GAAGCCAGTCATCAAATCCCAGCCAGTGCCCAAGAACAACAAGGGACCCGTCAAGGTCGTGGTGGGAAAGACCTTTGACTCCATTGTGAT GGACCCCAAGAAGGACGTCCTCATCGAGTTCTACGCGCCATGGTGCGGGCACTGCAAGCAGCTAGAGCCCGTGTACAACAGCCTGGCCAA GAAGTACAAGGGCCAAAAGGGCCTGGTCATCGCCAAGATGGACGCCACTGCCAACGACGTCCCCAGCGACCGCTATAAGGTGGAGGGCTT CCCCACCATCTACTTCGCCCCCAGTGGGGACAAAAAGAACCCAGTTAAATTTGAGGGTGGAGACAGAGATCTGGAGCATTTGAGCAAGTT TATAGAAGAACATGCCACAAAACTGAGCAGGACCAAGGAAGAGCTTTGAAGGCCTGAGGTCTGCGGAAGGTGGGAGGAGGCAGACGCCCT GCGTGGCCCATGGTCGGGGCGTCCACGCCGAGGCCGGCAACAAACGACAGTATCTCGGATTCCTTTTTTTTTTTTTTTAATTTTTTATAC TTTGGTGTTTCACTTCATGCTCTGAATACTGAATAACCATGAATGACTGAATAGTTTAGTCCAGATTTTTACAGAGGATACATCTATTTT TATCATTATTTGGGGTTTGAAAAATTTTTTTTTACACCTTCTAATTTCTTTATTTCTCAAAGCAGATAATTCTTCTGTGTGAAAATGTTT TCTTTTTTTAATTTAAGGTTTAAAATTCCTTTTCCAAATCATGTTGATTTTGCTCTTTGCTTTTTCGTTGTCTGAGAAATTGTTGGCGTA GATTTGGCTTCTGGTATGTGTTTCTGATTGCTTCCTGTTGAGCACAAAGTGAGAGCTGCCACTGAGCAGCCCTGCCAGGGGTGCTGTTTC AGGCTGGGCATCGCCAGGCGGCCTCCCTGCAAACCAAGGGCTGGGGGCAAAGGGGCATGATCCAGGGTCCCCCAGGGTGGGCTCAGCTCC AGGGAGAGGCCACCCACGTGGCAGCCCCACCTCTTGAGAGCCCCCAGTGCCGGAGCAGAAAGGACCCTGGACCCAGAGGCAGATACTGCG >60265_60265_5_NRF1-PDIA4_NRF1_chr7_129367205_ENST00000393231_PDIA4_chr7_148718239_ENST00000286091_length(amino acids)=1065AA_BP=449 MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSADEDSPSSPEDTSYDDSDILNSTAADEVTAHLAAAGPVGMAAAAAVATGKK RKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLENVVRKYKSMILEDLESALAEHAPAPQE VNSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQRVSWTQALRTIVKNCY KQHGREDLLYAFEDQQTQTQATATHSIAHLVPSQTVVQTFSNPDGTVSLIQVGTGATVATLADASELPTTVTVAQVNYSAVADGEVEQNW ATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQQGATVTMALNSEAAAHAVATLAEATLQGGGQIVLSGETAAAVGALTGVQDAND SSNRENAIEDEEEEEEEDDDEEEDDLEVKEENGVLVLNDANFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKI DATSASVLASRFDVSGYPTIKILKKGQAVDYEGSRTQEEIVAKVREVSQPDWTPPPEVTLVLTKENFDEVVNDADIILVEFYAPWCGHCK KLAPEYEKAAKELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTLKIFRKGRPYDYNGPREKYGIVDYMIEQSGPPSKEILTLKQVQEFL KDGDDVIIIGVFKGESDPAYQQYQDAANNLREDYKFHHTFSTEIAKFLKVSQGQLVVMQPEKFQSKYEPRSHMMDVQGSTQDSAIKDFVL KYALPLVGHRKVSNDAKRYTRRPLVVVYYSVDFSFDYRAATQFWRSKVLEVAKDFPEYTFAIADEEDYAGEVKDLGLSESGEDVNAAILD ESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIKSQPVPKNNKGPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAK -------------------------------------------------------------- >60265_60265_6_NRF1-PDIA4_NRF1_chr7_129367205_ENST00000393232_PDIA4_chr7_148718239_ENST00000286091_length(transcript)=4047nt_BP=1465nt GGCGGCAGAAGCGGCAGCGCTCGCCATTGCCGCTGGTGGCAGGAGGCTGCGAGGAGCCGGCGCGGTCGCAGTCTCCACGGCGCAGGCCCA CGGTAGCGCAGCCGCTCTGAGAACTTCATGGAGGAACACGGAGTGACCCAAACCGAACATATGGCTACCATAGAAGCACATGCAGTGGCC CAGCAAGTGCAGCAGGTCCATGTGGCTACTTACACCGAGCATAGTATGCTGAGTGCTGATGAAGACTCGCCTTCTTCTCCCGAGGACACC TCTTACGATGACTCAGATATACTCAACTCCACAGCAGCTGATGAGGTGACAGCTCATCTGGCAGCTGCAGGTCCTGTGGGAATGGCCGCT GCTGCTGCTGTGGCAACAGGAAAGAAACGGAAACGGCCTCATGTATTTGAGTCTAATCCATCTATCCGGAAGAGGCAACAAACACGTTTG CTTCGGAAACTTCGAGCCACGTTAGATGAATATACTACTCGTGTGGGACAGCAAGCTATTGTCCTCTGTATCTCACCCTCCAAACCTAAC CCTGTCTTTAAAGTGTTTGGTGCAGCACCTTTGGAGAATGTGGTGCGTAAGTACAAGAGCATGATCCTGGAAGACCTGGAGTCTGCTCTG GCAGAACACGCCCCTGCGCCACAGGAGGTTAACTCAGAACTGCCGCCTCTCACCATCGACGGAATTCCAGTCTCTGTGGACAAAATGACC CAGGCCCAGCTTCGGGCATTTATCCCAGAGATGCTCAAGTACTCTACAGGTCGGGGAAAACCAGGCTGGGGGAAAGAAAGCTGCAAGCCC ATCTGGTGGCCTGAAGATATCCCCTGGGCAAATGTCCGGAGTGATGTCCGCACAGAAGAGCAAAAGCAGAGGGTTTCATGGACCCAGGCA CTACGGACCATAGTTAAAAACTGTTATAAACAGCATGGGCGGGAAGACCTTTTGTATGCCTTTGAAGATCAGCAAACGCAAACACAGGCC ACAGCCACACATAGTATAGCTCATCTTGTACCATCACAGACTGTAGTCCAGACTTTTAGTAACCCTGATGGCACTGTCTCACTTATCCAG GTTGGTACGGGGGCAACAGTAGCCACATTGGCTGATGCTTCAGAATTGCCAACCACGGTCACCGTTGCCCAAGTGAATTATTCTGCCGTG GCTGATGGAGAGGTGGAACAAAATTGGGCCACGTTACAGGGAGGTGAGATGACCATCCAGACGACGCAAGCATCAGAGGCCACCCAGGCG GTGGCATCGTTGGCAGAGGCCGCAGTGGCAGCTTCTCAGGAGATGCAGCAGGGAGCTACAGTCACTATGGCGCTTAACAGCGAAGCTGCC GCCCATGCTGTCGCCACCCTGGCTGAGGCCACCTTACAAGGTGGGGGACAGATCGTCTTGTCTGGGGAAACCGCAGCAGCCGTCGGAGCA CTTACTGGAGTCCAAGATGCTAATGATTCTTCTAACAGAGAAAATGCCATTGAGGATGAAGAGGAGGAGGAGGAGGAAGATGATGATGAG GAAGAAGACGACTTGGAAGTTAAGGAAGAAAATGGAGTCTTGGTCCTAAATGATGCAAACTTTGATAATTTTGTGGCTGACAAAGACACA GTGCTGCTGGAGTTTTATGCTCCATGGTGTGGACATTGCAAGCAGTTTGCTCCGGAATATGAAAAAATTGCCAACATATTAAAGGATAAA GATCCTCCCATTCCTGTTGCCAAGATCGATGCAACCTCAGCGTCTGTGCTGGCCAGCAGGTTTGATGTGAGTGGCTACCCCACCATCAAG ATCCTTAAGAAGGGGCAGGCTGTAGACTACGAGGGCTCCAGAACCCAGGAAGAAATTGTTGCCAAGGTCAGAGAAGTCTCCCAGCCCGAC TGGACGCCTCCACCAGAAGTCACGCTTGTGTTGACCAAAGAGAACTTTGATGAAGTTGTGAATGATGCAGATATCATTCTGGTGGAGTTT TATGCCCCATGGTGTGGACACTGCAAGAAACTTGCCCCCGAGTATGAGAAGGCCGCCAAGGAGCTCAGCAAGCGTTCTCCTCCAATTCCC CTGGCAAAGGTCGACGCCACCGCAGAAACAGACCTGGCCAAGAGGTTTGATGTCTCTGGCTATCCCACCCTGAAAATTTTCCGCAAAGGA AGGCCTTATGACTACAACGGCCCACGAGAAAAATATGGAATCGTTGATTACATGATCGAGCAGTCCGGGCCTCCCTCCAAGGAGATTCTG ACCCTGAAGCAGGTCCAGGAGTTCCTGAAGGATGGAGACGATGTCATCATCATCGGGGTCTTTAAGGGGGAGAGTGACCCAGCCTACCAG CAATACCAGGATGCCGCTAACAACCTGAGAGAAGATTACAAATTTCACCACACTTTCAGCACAGAAATAGCAAAGTTCTTGAAAGTCTCC CAGGGGCAGTTGGTTGTAATGCAGCCTGAGAAATTCCAGTCCAAGTATGAGCCCCGGAGCCACATGATGGACGTCCAGGGCTCCACCCAG GACTCGGCCATCAAGGACTTCGTGCTGAAGTACGCCCTGCCCCTGGTTGGCCACCGCAAGGTGTCAAACGATGCTAAGCGCTACACCAGG CGCCCCCTGGTGGTCGTCTACTACAGTGTGGACTTCAGCTTTGATTACAGAGCTGCAACTCAGTTTTGGCGGAGCAAAGTCCTAGAGGTG GCCAAGGACTTCCCTGAGTACACCTTTGCCATTGCGGACGAAGAGGACTATGCTGGGGAGGTGAAGGACCTGGGGCTCAGCGAGAGTGGG GAGGATGTCAATGCCGCCATCCTGGACGAGAGTGGGAAGAAGTTCGCCATGGAGCCAGAGGAGTTTGACTCTGACACCCTCCGCGAGTTT GTCACTGCTTTCAAAAAAGGAAAACTGAAGCCAGTCATCAAATCCCAGCCAGTGCCCAAGAACAACAAGGGACCCGTCAAGGTCGTGGTG GGAAAGACCTTTGACTCCATTGTGATGGACCCCAAGAAGGACGTCCTCATCGAGTTCTACGCGCCATGGTGCGGGCACTGCAAGCAGCTA GAGCCCGTGTACAACAGCCTGGCCAAGAAGTACAAGGGCCAAAAGGGCCTGGTCATCGCCAAGATGGACGCCACTGCCAACGACGTCCCC AGCGACCGCTATAAGGTGGAGGGCTTCCCCACCATCTACTTCGCCCCCAGTGGGGACAAAAAGAACCCAGTTAAATTTGAGGGTGGAGAC AGAGATCTGGAGCATTTGAGCAAGTTTATAGAAGAACATGCCACAAAACTGAGCAGGACCAAGGAAGAGCTTTGAAGGCCTGAGGTCTGC GGAAGGTGGGAGGAGGCAGACGCCCTGCGTGGCCCATGGTCGGGGCGTCCACGCCGAGGCCGGCAACAAACGACAGTATCTCGGATTCCT TTTTTTTTTTTTTTAATTTTTTATACTTTGGTGTTTCACTTCATGCTCTGAATACTGAATAACCATGAATGACTGAATAGTTTAGTCCAG ATTTTTACAGAGGATACATCTATTTTTATCATTATTTGGGGTTTGAAAAATTTTTTTTTACACCTTCTAATTTCTTTATTTCTCAAAGCA GATAATTCTTCTGTGTGAAAATGTTTTCTTTTTTTAATTTAAGGTTTAAAATTCCTTTTCCAAATCATGTTGATTTTGCTCTTTGCTTTT TCGTTGTCTGAGAAATTGTTGGCGTAGATTTGGCTTCTGGTATGTGTTTCTGATTGCTTCCTGTTGAGCACAAAGTGAGAGCTGCCACTG AGCAGCCCTGCCAGGGGTGCTGTTTCAGGCTGGGCATCGCCAGGCGGCCTCCCTGCAAACCAAGGGCTGGGGGCAAAGGGGCATGATCCA GGGTCCCCCAGGGTGGGCTCAGCTCCAGGGAGAGGCCACCCACGTGGCAGCCCCACCTCTTGAGAGCCCCCAGTGCCGGAGCAGAAAGGA >60265_60265_6_NRF1-PDIA4_NRF1_chr7_129367205_ENST00000393232_PDIA4_chr7_148718239_ENST00000286091_length(amino acids)=1065AA_BP=449 MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSADEDSPSSPEDTSYDDSDILNSTAADEVTAHLAAAGPVGMAAAAAVATGKK RKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLENVVRKYKSMILEDLESALAEHAPAPQE VNSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQRVSWTQALRTIVKNCY KQHGREDLLYAFEDQQTQTQATATHSIAHLVPSQTVVQTFSNPDGTVSLIQVGTGATVATLADASELPTTVTVAQVNYSAVADGEVEQNW ATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQQGATVTMALNSEAAAHAVATLAEATLQGGGQIVLSGETAAAVGALTGVQDAND SSNRENAIEDEEEEEEEDDDEEEDDLEVKEENGVLVLNDANFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKI DATSASVLASRFDVSGYPTIKILKKGQAVDYEGSRTQEEIVAKVREVSQPDWTPPPEVTLVLTKENFDEVVNDADIILVEFYAPWCGHCK KLAPEYEKAAKELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTLKIFRKGRPYDYNGPREKYGIVDYMIEQSGPPSKEILTLKQVQEFL KDGDDVIIIGVFKGESDPAYQQYQDAANNLREDYKFHHTFSTEIAKFLKVSQGQLVVMQPEKFQSKYEPRSHMMDVQGSTQDSAIKDFVL KYALPLVGHRKVSNDAKRYTRRPLVVVYYSVDFSFDYRAATQFWRSKVLEVAKDFPEYTFAIADEEDYAGEVKDLGLSESGEDVNAAILD ESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIKSQPVPKNNKGPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAK -------------------------------------------------------------- >60265_60265_7_NRF1-PDIA4_NRF1_chr7_129367205_ENST00000539636_PDIA4_chr7_148718239_ENST00000286091_length(transcript)=3910nt_BP=1328nt ATTGCCGCTGGTGGCAGGAGGCTGCGAGGAGCCGGCGCGGTCGCAGTCTCCACGGCGCAGGCCCACGGTAGCGCAGCCGCTCTGAGTAGA ACTTCATGGAGGAACACGGAGTGACCCAAACCGAACATATGGCTACCATAGAAGCACATGCAGTGGCCCAGCAAGTGCAGCAGGTCCATG TGGCTACTTACACCGAGCATAGTATGCTGAGTGCTGATGAAGACTCGCCTTCTTCTCCCGAGGACACCTCTTACGATGACTCAGATATAC TCAACTCCACAGCAGCTGATGAGGTGACAGCTCATCTGGCAGCTGCAGGAAACTTCGAGCCACGTTAGATGAATATACTACTCGTGTGGG ACAGCAAGCTATTGTCCTCTGTATCTCACCCTCCAAACCTAACCCTGTCTTTAAAGTGTTTGGTGCAGCACCTTTGGAGAATGTGGTGCG TAAGTACAAGAGCATGATCCTGGAAGACCTGGAGTCTGCTCTGGCAGAACACGCCCCTGCGCCACAGGAGGTTAACTCAGAACTGCCGCC TCTCACCATCGACGGAATTCCAGTCTCTGTGGACAAAATGACCCAGGCCCAGCTTCGGGCATTTATCCCAGAGATGCTCAAGTACTCTAC AGGTCGGGGAAAACCAGGCTGGGGGAAAGAAAGCTGCAAGCCCATCTGGTGGCCTGAAGATATCCCCTGGGCAAATGTCCGGAGTGATGT CCGCACAGAAGAGCAAAAGCAGAGGGTTTCATGGACCCAGGCACTACGGACCATAGTTAAAAACTGTTATAAACAGCATGGGCGGGAAGA CCTTTTGTATGCCTTTGAAGATCAGCAAACGCAAACACAGGCCACAGCCACACATAGTATAGCTCATCTTGTACCATCACAGACTGTAGT CCAGACTTTTAGTAACCCTGATGGCACTGTCTCACTTATCCAGGTTGGTACGGGGGCAACAGTAGCCACATTGGCTGATGCTTCAGAATT GCCAACCACGGTCACCGTTGCCCAAGTGAATTATTCTGCCGTGGCTGATGGAGAGGTGGAACAAAATTGGGCCACGTTACAGGGAGGTGA GATGACCATCCAGACGACGCAAGCATCAGAGGCCACCCAGGCGGTGGCATCGTTGGCAGAGGCCGCAGTGGCAGCTTCTCAGGAGATGCA GCAGGGAGCTACAGTCACTATGGCGCTTAACAGCGAAGCTGCCGCCCATGCTGTCGCCACCCTGGCTGAGGCCACCTTACAAGGTGGGGG ACAGATCGTCTTGTCTGGGGAAACCGCAGCAGCCGTCGGAGCACTTACTGGAGTCCAAGATGCTAATGATTCTTCTAACAGAGAAAATGC CATTGAGGATGAAGAGGAGGAGGAGGAGGAAGATGATGATGAGGAAGAAGACGACTTGGAAGTTAAGGAAGAAAATGGAGTCTTGGTCCT AAATGATGCAAACTTTGATAATTTTGTGGCTGACAAAGACACAGTGCTGCTGGAGTTTTATGCTCCATGGTGTGGACATTGCAAGCAGTT TGCTCCGGAATATGAAAAAATTGCCAACATATTAAAGGATAAAGATCCTCCCATTCCTGTTGCCAAGATCGATGCAACCTCAGCGTCTGT GCTGGCCAGCAGGTTTGATGTGAGTGGCTACCCCACCATCAAGATCCTTAAGAAGGGGCAGGCTGTAGACTACGAGGGCTCCAGAACCCA GGAAGAAATTGTTGCCAAGGTCAGAGAAGTCTCCCAGCCCGACTGGACGCCTCCACCAGAAGTCACGCTTGTGTTGACCAAAGAGAACTT TGATGAAGTTGTGAATGATGCAGATATCATTCTGGTGGAGTTTTATGCCCCATGGTGTGGACACTGCAAGAAACTTGCCCCCGAGTATGA GAAGGCCGCCAAGGAGCTCAGCAAGCGTTCTCCTCCAATTCCCCTGGCAAAGGTCGACGCCACCGCAGAAACAGACCTGGCCAAGAGGTT TGATGTCTCTGGCTATCCCACCCTGAAAATTTTCCGCAAAGGAAGGCCTTATGACTACAACGGCCCACGAGAAAAATATGGAATCGTTGA TTACATGATCGAGCAGTCCGGGCCTCCCTCCAAGGAGATTCTGACCCTGAAGCAGGTCCAGGAGTTCCTGAAGGATGGAGACGATGTCAT CATCATCGGGGTCTTTAAGGGGGAGAGTGACCCAGCCTACCAGCAATACCAGGATGCCGCTAACAACCTGAGAGAAGATTACAAATTTCA CCACACTTTCAGCACAGAAATAGCAAAGTTCTTGAAAGTCTCCCAGGGGCAGTTGGTTGTAATGCAGCCTGAGAAATTCCAGTCCAAGTA TGAGCCCCGGAGCCACATGATGGACGTCCAGGGCTCCACCCAGGACTCGGCCATCAAGGACTTCGTGCTGAAGTACGCCCTGCCCCTGGT TGGCCACCGCAAGGTGTCAAACGATGCTAAGCGCTACACCAGGCGCCCCCTGGTGGTCGTCTACTACAGTGTGGACTTCAGCTTTGATTA CAGAGCTGCAACTCAGTTTTGGCGGAGCAAAGTCCTAGAGGTGGCCAAGGACTTCCCTGAGTACACCTTTGCCATTGCGGACGAAGAGGA CTATGCTGGGGAGGTGAAGGACCTGGGGCTCAGCGAGAGTGGGGAGGATGTCAATGCCGCCATCCTGGACGAGAGTGGGAAGAAGTTCGC CATGGAGCCAGAGGAGTTTGACTCTGACACCCTCCGCGAGTTTGTCACTGCTTTCAAAAAAGGAAAACTGAAGCCAGTCATCAAATCCCA GCCAGTGCCCAAGAACAACAAGGGACCCGTCAAGGTCGTGGTGGGAAAGACCTTTGACTCCATTGTGATGGACCCCAAGAAGGACGTCCT CATCGAGTTCTACGCGCCATGGTGCGGGCACTGCAAGCAGCTAGAGCCCGTGTACAACAGCCTGGCCAAGAAGTACAAGGGCCAAAAGGG CCTGGTCATCGCCAAGATGGACGCCACTGCCAACGACGTCCCCAGCGACCGCTATAAGGTGGAGGGCTTCCCCACCATCTACTTCGCCCC CAGTGGGGACAAAAAGAACCCAGTTAAATTTGAGGGTGGAGACAGAGATCTGGAGCATTTGAGCAAGTTTATAGAAGAACATGCCACAAA ACTGAGCAGGACCAAGGAAGAGCTTTGAAGGCCTGAGGTCTGCGGAAGGTGGGAGGAGGCAGACGCCCTGCGTGGCCCATGGTCGGGGCG TCCACGCCGAGGCCGGCAACAAACGACAGTATCTCGGATTCCTTTTTTTTTTTTTTTAATTTTTTATACTTTGGTGTTTCACTTCATGCT CTGAATACTGAATAACCATGAATGACTGAATAGTTTAGTCCAGATTTTTACAGAGGATACATCTATTTTTATCATTATTTGGGGTTTGAA AAATTTTTTTTTACACCTTCTAATTTCTTTATTTCTCAAAGCAGATAATTCTTCTGTGTGAAAATGTTTTCTTTTTTTAATTTAAGGTTT AAAATTCCTTTTCCAAATCATGTTGATTTTGCTCTTTGCTTTTTCGTTGTCTGAGAAATTGTTGGCGTAGATTTGGCTTCTGGTATGTGT TTCTGATTGCTTCCTGTTGAGCACAAAGTGAGAGCTGCCACTGAGCAGCCCTGCCAGGGGTGCTGTTTCAGGCTGGGCATCGCCAGGCGG CCTCCCTGCAAACCAAGGGCTGGGGGCAAAGGGGCATGATCCAGGGTCCCCCAGGGTGGGCTCAGCTCCAGGGAGAGGCCACCCACGTGG CAGCCCCACCTCTTGAGAGCCCCCAGTGCCGGAGCAGAAAGGACCCTGGACCCAGAGGCAGATACTGCGGGGTGGTAGAAAAGGTAGAGT >60265_60265_7_NRF1-PDIA4_NRF1_chr7_129367205_ENST00000539636_PDIA4_chr7_148718239_ENST00000286091_length(amino acids)=914AA_BP=298 MENVVRKYKSMILEDLESALAEHAPAPQEVNSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWA NVRSDVRTEEQKQRVSWTQALRTIVKNCYKQHGREDLLYAFEDQQTQTQATATHSIAHLVPSQTVVQTFSNPDGTVSLIQVGTGATVATL ADASELPTTVTVAQVNYSAVADGEVEQNWATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQQGATVTMALNSEAAAHAVATLAEA TLQGGGQIVLSGETAAAVGALTGVQDANDSSNRENAIEDEEEEEEEDDDEEEDDLEVKEENGVLVLNDANFDNFVADKDTVLLEFYAPWC GHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVSGYPTIKILKKGQAVDYEGSRTQEEIVAKVREVSQPDWTPPPEVTLV LTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTLKIFRKGRPYDYNGPRE KYGIVDYMIEQSGPPSKEILTLKQVQEFLKDGDDVIIIGVFKGESDPAYQQYQDAANNLREDYKFHHTFSTEIAKFLKVSQGQLVVMQPE KFQSKYEPRSHMMDVQGSTQDSAIKDFVLKYALPLVGHRKVSNDAKRYTRRPLVVVYYSVDFSFDYRAATQFWRSKVLEVAKDFPEYTFA IADEEDYAGEVKDLGLSESGEDVNAAILDESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIKSQPVPKNNKGPVKVVVGKTFDSIVMD PKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDLEHLSKFI -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for NRF1-PDIA4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for NRF1-PDIA4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for NRF1-PDIA4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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