|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:NRF1-ZNRF2 (FusionGDB2 ID:60271) |
Fusion Gene Summary for NRF1-ZNRF2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NRF1-ZNRF2 | Fusion gene ID: 60271 | Hgene | Tgene | Gene symbol | NRF1 | ZNRF2 | Gene ID | 4899 | 223082 |
| Gene name | nuclear respiratory factor 1 | zinc and ring finger 2 | |
| Synonyms | ALPHA-PAL | RNF202 | |
| Cytomap | 7q32.2 | 7p14.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear respiratory factor 1alpha palindromic-binding protein | E3 ubiquitin-protein ligase ZNRF2RING finger protein 202RING-type E3 ubiquitin transferase ZNRF2protein Ells2zinc and ring finger 2, E3 ubiquitin protein ligasezinc finger/RING finger 2zinc/RING finger protein 2 | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000223190, ENST00000311967, ENST00000353868, ENST00000393230, ENST00000393231, ENST00000393232, ENST00000539636, ENST00000477428, | ENST00000459998, ENST00000323037, | |
| Fusion gene scores | * DoF score | 14 X 9 X 8=1008 | 7 X 4 X 4=112 |
| # samples | 16 | 7 | |
| ** MAII score | log2(16/1008*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/112*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NRF1 [Title/Abstract] AND ZNRF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | NRF1(129367205)-ZNRF2(30363258), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across NRF1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across ZNRF2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-EQ-A4SO-01A | NRF1 | chr7 | 129367205 | + | ZNRF2 | chr7 | 30363258 | + |
Top |
Fusion Gene ORF analysis for NRF1-ZNRF2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000223190 | ENST00000459998 | NRF1 | chr7 | 129367205 | + | ZNRF2 | chr7 | 30363258 | + |
| 5CDS-intron | ENST00000311967 | ENST00000459998 | NRF1 | chr7 | 129367205 | + | ZNRF2 | chr7 | 30363258 | + |
| 5CDS-intron | ENST00000353868 | ENST00000459998 | NRF1 | chr7 | 129367205 | + | ZNRF2 | chr7 | 30363258 | + |
| 5CDS-intron | ENST00000393230 | ENST00000459998 | NRF1 | chr7 | 129367205 | + | ZNRF2 | chr7 | 30363258 | + |
| 5CDS-intron | ENST00000393231 | ENST00000459998 | NRF1 | chr7 | 129367205 | + | ZNRF2 | chr7 | 30363258 | + |
| 5CDS-intron | ENST00000393232 | ENST00000459998 | NRF1 | chr7 | 129367205 | + | ZNRF2 | chr7 | 30363258 | + |
| 5CDS-intron | ENST00000539636 | ENST00000459998 | NRF1 | chr7 | 129367205 | + | ZNRF2 | chr7 | 30363258 | + |
| In-frame | ENST00000223190 | ENST00000323037 | NRF1 | chr7 | 129367205 | + | ZNRF2 | chr7 | 30363258 | + |
| In-frame | ENST00000311967 | ENST00000323037 | NRF1 | chr7 | 129367205 | + | ZNRF2 | chr7 | 30363258 | + |
| In-frame | ENST00000353868 | ENST00000323037 | NRF1 | chr7 | 129367205 | + | ZNRF2 | chr7 | 30363258 | + |
| In-frame | ENST00000393230 | ENST00000323037 | NRF1 | chr7 | 129367205 | + | ZNRF2 | chr7 | 30363258 | + |
| In-frame | ENST00000393231 | ENST00000323037 | NRF1 | chr7 | 129367205 | + | ZNRF2 | chr7 | 30363258 | + |
| In-frame | ENST00000393232 | ENST00000323037 | NRF1 | chr7 | 129367205 | + | ZNRF2 | chr7 | 30363258 | + |
| In-frame | ENST00000539636 | ENST00000323037 | NRF1 | chr7 | 129367205 | + | ZNRF2 | chr7 | 30363258 | + |
| intron-3CDS | ENST00000477428 | ENST00000323037 | NRF1 | chr7 | 129367205 | + | ZNRF2 | chr7 | 30363258 | + |
| intron-intron | ENST00000477428 | ENST00000459998 | NRF1 | chr7 | 129367205 | + | ZNRF2 | chr7 | 30363258 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000393232 | NRF1 | chr7 | 129367205 | + | ENST00000323037 | ZNRF2 | chr7 | 30363258 | + | 3405 | 1465 | 117 | 1724 | 535 |
| ENST00000353868 | NRF1 | chr7 | 129367205 | + | ENST00000323037 | ZNRF2 | chr7 | 30363258 | + | 3207 | 1267 | 117 | 1526 | 469 |
| ENST00000539636 | NRF1 | chr7 | 129367205 | + | ENST00000323037 | ZNRF2 | chr7 | 30363258 | + | 3268 | 1328 | 433 | 1587 | 384 |
| ENST00000311967 | NRF1 | chr7 | 129367205 | + | ENST00000323037 | ZNRF2 | chr7 | 30363258 | + | 3366 | 1426 | 78 | 1685 | 535 |
| ENST00000223190 | NRF1 | chr7 | 129367205 | + | ENST00000323037 | ZNRF2 | chr7 | 30363258 | + | 3366 | 1426 | 78 | 1685 | 535 |
| ENST00000393230 | NRF1 | chr7 | 129367205 | + | ENST00000323037 | ZNRF2 | chr7 | 30363258 | + | 3398 | 1458 | 110 | 1717 | 535 |
| ENST00000393231 | NRF1 | chr7 | 129367205 | + | ENST00000323037 | ZNRF2 | chr7 | 30363258 | + | 3289 | 1349 | 1 | 1608 | 535 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000393232 | ENST00000323037 | NRF1 | chr7 | 129367205 | + | ZNRF2 | chr7 | 30363258 | + | 0.000663315 | 0.99933666 |
| ENST00000353868 | ENST00000323037 | NRF1 | chr7 | 129367205 | + | ZNRF2 | chr7 | 30363258 | + | 0.000649391 | 0.9993506 |
| ENST00000539636 | ENST00000323037 | NRF1 | chr7 | 129367205 | + | ZNRF2 | chr7 | 30363258 | + | 0.000363339 | 0.99963665 |
| ENST00000311967 | ENST00000323037 | NRF1 | chr7 | 129367205 | + | ZNRF2 | chr7 | 30363258 | + | 0.000617674 | 0.99938226 |
| ENST00000223190 | ENST00000323037 | NRF1 | chr7 | 129367205 | + | ZNRF2 | chr7 | 30363258 | + | 0.000617674 | 0.99938226 |
| ENST00000393230 | ENST00000323037 | NRF1 | chr7 | 129367205 | + | ZNRF2 | chr7 | 30363258 | + | 0.000559563 | 0.9994404 |
| ENST00000393231 | ENST00000323037 | NRF1 | chr7 | 129367205 | + | ZNRF2 | chr7 | 30363258 | + | 0.000565887 | 0.99943405 |
Top |
Fusion Genomic Features for NRF1-ZNRF2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| NRF1 | chr7 | 129367205 | + | ZNRF2 | chr7 | 30363257 | + | 3.18E-06 | 0.9999968 |
| NRF1 | chr7 | 129367205 | + | ZNRF2 | chr7 | 30363257 | + | 3.18E-06 | 0.9999968 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
 |
Top |
Fusion Protein Features for NRF1-ZNRF2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:129367205/chr7:30363258) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NRF1 | chr7:129367205 | chr7:30363258 | ENST00000223190 | + | 10 | 11 | 41_66 | 449 | 504.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | NRF1 | chr7:129367205 | chr7:30363258 | ENST00000223190 | + | 10 | 11 | 80_86 | 449 | 504.0 | Compositional bias | Note=Poly-Ala |
| Hgene | NRF1 | chr7:129367205 | chr7:30363258 | ENST00000353868 | + | 9 | 10 | 41_66 | 383 | 438.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | NRF1 | chr7:129367205 | chr7:30363258 | ENST00000353868 | + | 9 | 10 | 80_86 | 383 | 438.0 | Compositional bias | Note=Poly-Ala |
| Hgene | NRF1 | chr7:129367205 | chr7:30363258 | ENST00000393230 | + | 10 | 11 | 41_66 | 449 | 504.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | NRF1 | chr7:129367205 | chr7:30363258 | ENST00000393230 | + | 10 | 11 | 80_86 | 449 | 504.0 | Compositional bias | Note=Poly-Ala |
| Hgene | NRF1 | chr7:129367205 | chr7:30363258 | ENST00000393232 | + | 10 | 11 | 41_66 | 449 | 504.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | NRF1 | chr7:129367205 | chr7:30363258 | ENST00000393232 | + | 10 | 11 | 80_86 | 449 | 504.0 | Compositional bias | Note=Poly-Ala |
| Hgene | NRF1 | chr7:129367205 | chr7:30363258 | ENST00000223190 | + | 10 | 11 | 109_305 | 449 | 504.0 | DNA binding | . |
| Hgene | NRF1 | chr7:129367205 | chr7:30363258 | ENST00000353868 | + | 9 | 10 | 109_305 | 383 | 438.0 | DNA binding | . |
| Hgene | NRF1 | chr7:129367205 | chr7:30363258 | ENST00000393230 | + | 10 | 11 | 109_305 | 449 | 504.0 | DNA binding | . |
| Hgene | NRF1 | chr7:129367205 | chr7:30363258 | ENST00000393232 | + | 10 | 11 | 109_305 | 449 | 504.0 | DNA binding | . |
| Hgene | NRF1 | chr7:129367205 | chr7:30363258 | ENST00000223190 | + | 10 | 11 | 88_116 | 449 | 504.0 | Motif | Note=Nuclear localization signal |
| Hgene | NRF1 | chr7:129367205 | chr7:30363258 | ENST00000353868 | + | 9 | 10 | 88_116 | 383 | 438.0 | Motif | Note=Nuclear localization signal |
| Hgene | NRF1 | chr7:129367205 | chr7:30363258 | ENST00000393230 | + | 10 | 11 | 88_116 | 449 | 504.0 | Motif | Note=Nuclear localization signal |
| Hgene | NRF1 | chr7:129367205 | chr7:30363258 | ENST00000393232 | + | 10 | 11 | 88_116 | 449 | 504.0 | Motif | Note=Nuclear localization signal |
| Hgene | NRF1 | chr7:129367205 | chr7:30363258 | ENST00000223190 | + | 10 | 11 | 1_78 | 449 | 504.0 | Region | Note=Dimerization |
| Hgene | NRF1 | chr7:129367205 | chr7:30363258 | ENST00000353868 | + | 9 | 10 | 1_78 | 383 | 438.0 | Region | Note=Dimerization |
| Hgene | NRF1 | chr7:129367205 | chr7:30363258 | ENST00000393230 | + | 10 | 11 | 1_78 | 449 | 504.0 | Region | Note=Dimerization |
| Hgene | NRF1 | chr7:129367205 | chr7:30363258 | ENST00000393232 | + | 10 | 11 | 1_78 | 449 | 504.0 | Region | Note=Dimerization |
| Tgene | ZNRF2 | chr7:129367205 | chr7:30363258 | ENST00000323037 | 0 | 5 | 199_240 | 156 | 289.0 | Zinc finger | RING-type%3B atypical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NRF1 | chr7:129367205 | chr7:30363258 | ENST00000223190 | + | 10 | 11 | 301_476 | 449 | 504.0 | Region | Note=Required for transcriptional activation |
| Hgene | NRF1 | chr7:129367205 | chr7:30363258 | ENST00000353868 | + | 9 | 10 | 301_476 | 383 | 438.0 | Region | Note=Required for transcriptional activation |
| Hgene | NRF1 | chr7:129367205 | chr7:30363258 | ENST00000393230 | + | 10 | 11 | 301_476 | 449 | 504.0 | Region | Note=Required for transcriptional activation |
| Hgene | NRF1 | chr7:129367205 | chr7:30363258 | ENST00000393232 | + | 10 | 11 | 301_476 | 449 | 504.0 | Region | Note=Required for transcriptional activation |
| Tgene | ZNRF2 | chr7:129367205 | chr7:30363258 | ENST00000323037 | 0 | 5 | 124_127 | 156 | 289.0 | Compositional bias | Note=Poly-Gly | |
| Tgene | ZNRF2 | chr7:129367205 | chr7:30363258 | ENST00000323037 | 0 | 5 | 36_40 | 156 | 289.0 | Compositional bias | Note=Poly-Gly | |
| Tgene | ZNRF2 | chr7:129367205 | chr7:30363258 | ENST00000323037 | 0 | 5 | 41_97 | 156 | 289.0 | Compositional bias | Note=Ala-rich |
Top |
Fusion Gene Sequence for NRF1-ZNRF2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >60271_60271_1_NRF1-ZNRF2_NRF1_chr7_129367205_ENST00000223190_ZNRF2_chr7_30363258_ENST00000323037_length(transcript)=3366nt_BP=1426nt GAGGCTGCGAGGAGCCGGCGCGGTCGCAGTCTCCACGGCGCAGGCCCACGGTAGCGCAGCCGCTCTGAGTAGAACTTCATGGAGGAACAC GGAGTGACCCAAACCGAACATATGGCTACCATAGAAGCACATGCAGTGGCCCAGCAAGTGCAGCAGGTCCATGTGGCTACTTACACCGAG CATAGTATGCTGAGTGCTGATGAAGACTCGCCTTCTTCTCCCGAGGACACCTCTTACGATGACTCAGATATACTCAACTCCACAGCAGCT GATGAGGTGACAGCTCATCTGGCAGCTGCAGGTCCTGTGGGAATGGCCGCTGCTGCTGCTGTGGCAACAGGAAAGAAACGGAAACGGCCT CATGTATTTGAGTCTAATCCATCTATCCGGAAGAGGCAACAAACACGTTTGCTTCGGAAACTTCGAGCCACGTTAGATGAATATACTACT CGTGTGGGACAGCAAGCTATTGTCCTCTGTATCTCACCCTCCAAACCTAACCCTGTCTTTAAAGTGTTTGGTGCAGCACCTTTGGAGAAT GTGGTGCGTAAGTACAAGAGCATGATCCTGGAAGACCTGGAGTCTGCTCTGGCAGAACACGCCCCTGCGCCACAGGAGGTTAACTCAGAA CTGCCGCCTCTCACCATCGACGGAATTCCAGTCTCTGTGGACAAAATGACCCAGGCCCAGCTTCGGGCATTTATCCCAGAGATGCTCAAG TACTCTACAGGTCGGGGAAAACCAGGCTGGGGGAAAGAAAGCTGCAAGCCCATCTGGTGGCCTGAAGATATCCCCTGGGCAAATGTCCGG AGTGATGTCCGCACAGAAGAGCAAAAGCAGAGGGTTTCATGGACCCAGGCACTACGGACCATAGTTAAAAACTGTTATAAACAGCATGGG CGGGAAGACCTTTTGTATGCCTTTGAAGATCAGCAAACGCAAACACAGGCCACAGCCACACATAGTATAGCTCATCTTGTACCATCACAG ACTGTAGTCCAGACTTTTAGTAACCCTGATGGCACTGTCTCACTTATCCAGGTTGGTACGGGGGCAACAGTAGCCACATTGGCTGATGCT TCAGAATTGCCAACCACGGTCACCGTTGCCCAAGTGAATTATTCTGCCGTGGCTGATGGAGAGGTGGAACAAAATTGGGCCACGTTACAG GGAGGTGAGATGACCATCCAGACGACGCAAGCATCAGAGGCCACCCAGGCGGTGGCATCGTTGGCAGAGGCCGCAGTGGCAGCTTCTCAG GAGATGCAGCAGGGAGCTACAGTCACTATGGCGCTTAACAGCGAAGCTGCCGCCCATGCTGTCGCCACCCTGGCTGAGGCCACCTTACAA GGTGGGGGACAGATCGTCTTGTCTGGGGAAACCGCAGCAGCCGTCGGAGCACTTACTGGAGTCCAAGATGCTAATGGATTTAAGTGCCCT GTATGCTCAAAATTTGTATCCTCAGATGAAATGGATTTGCATCTTGTAATGTGTTTAACAAAGCCACGAATAACCTATAATGAGGATGTA CTGAGTAAAGATGCTGGGGAATGTGCAATATGCCTTGAAGAATTGCAGCAGGGAGATACTATAGCACGACTGCCTTGTCTATGCATATAT CATAAAGGCTGCATAGATGAATGGTTTGAAGTAAATAGATCTTGCCCTGAGCACCCTTCAGATTAAGCGTCAGCTTCCTGTTTTATAGGT TTTCTTGTCTTGACAAGATGCTTGAAAAACCAAGAGGATATGAAAATCTGTCTCTGGAGAAACAAAGACGCAGGCATACTCAGCCAGAAA TCTGAGTTTTGTGAGACTTGGTAATACAGAGATGGACAATCGTACTGGGGTAAAAAAACCCTGCTGAAGAGAGGACAGTGACCACAGAAC TCAGTGTACCAAACATGCATACAAAGGACACACAGGGATTTTGAAAATGCTGCACATCCCTTAATAGTCATCTACATAGGTAATACTGAT AAACATTTTGTATTCAGACGCCAAAGTTAACTGATTTAAAAGTTGATTTACTTTTTATTAAGTTCTCCAGAGCTGCACAACTAGTTATGT TTTGATTTGTTTTGTTTTTTAATTTGGGGTCTCTTTGTTTTCCCCAACATAATGTTCATAATGTTTCTGCATTCATCTGTTCTTAAATTG AAAAACATATAATTTACTTCTTATAAATTGAAGTCTTAAATGTGAAACCAAGAAATGTAATCAAGCAGTAAAAACATCTGAATGTAGACC ATGATCTCAAGTTCTTCCATTTTCTCCCCCACGAGTGGAAAATAGACTTCTACATAGGAAAGCTAAAATATGTTAATATTTTTAAATTAA AGGTTTAATATCAGAATGCAGTCCAAAGAGCAAATCATATTACATAATTACATTTTAATTAAATATAGAATATTCTACTGAATTGCAATT TATTAAATATTCTTATCCTCTTAAATAAAACTGCTCAACAGTTAATCAGCAGTGAATCATCTTGCAGCTATGCAATTTAAAAAAAATACA GATTACCAATTTCAAGTGCTGCCAGCTAAAATAACTGTTTTAACGGGTATCTTTTGTTTGTTCTTTTCACTTAATTATTTTATTGTGCTT TGCATCTCCAGGCAGTTCTCTCACATTTGGGTAAAATGTTTAGCAGGCTGTAAACTTAAGAAAAGGGTAAAATAAAATTTTCTGGAGAGG AACTTGGAATTTGAGGGAGATTTTATATACCTTTAAAAACTGTAATTTAATTGGGATGCCAGGTTTATAGCAATTTGCAACTTTAATTTT CCAGATAATCTGGAGGTTAGCATTTGATAAATGATTTTTTAAAGTAGATATGAAGATTTTGTTAATTTATAATTTATTCATGTGTTATTA CTGTAATTGAAAATGTTATAGACACTTTTAAATTCAGTTTGTGTAGAAAGAAATGTGTTAAACAAAATTATGTTAATAAATATTCCCACA TAATACATCTGAATGGTTAAAAATACTGGAAGAGTTGTCAGGGCTACAATAGTGAATGTCCTTTTTTTTAATATCAAAAATATCGATAAG TAGGTTTTGTGTTTTCAACGTAGGGAAAATGTTATCAGTGAATAGGTGGTGTACTTTACTTGGTATAATTTAAAGTTGCACAGTAAGTAC TGTTTCCTTATTTTAATCTTTCTTTACTCATAATGTATTTAAGAATTTGCTGTTTTATTTAACGCTGCTACTCTTAATCTTCTCTAAATT TTTCCCCCTACTTTCTTGCTTCTGTTTCACATTTTTTAAAAGGGCAAGTACAGGAGCAACTGCTGCTACCCAGAAAAATGTGTGTATTAT >60271_60271_1_NRF1-ZNRF2_NRF1_chr7_129367205_ENST00000223190_ZNRF2_chr7_30363258_ENST00000323037_length(amino acids)=535AA_BP=449 MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSADEDSPSSPEDTSYDDSDILNSTAADEVTAHLAAAGPVGMAAAAAVATGKK RKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLENVVRKYKSMILEDLESALAEHAPAPQE VNSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQRVSWTQALRTIVKNCY KQHGREDLLYAFEDQQTQTQATATHSIAHLVPSQTVVQTFSNPDGTVSLIQVGTGATVATLADASELPTTVTVAQVNYSAVADGEVEQNW ATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQQGATVTMALNSEAAAHAVATLAEATLQGGGQIVLSGETAAAVGALTGVQDANG -------------------------------------------------------------- >60271_60271_2_NRF1-ZNRF2_NRF1_chr7_129367205_ENST00000311967_ZNRF2_chr7_30363258_ENST00000323037_length(transcript)=3366nt_BP=1426nt GAGGCTGCGAGGAGCCGGCGCGGTCGCAGTCTCCACGGCGCAGGCCCACGGTAGCGCAGCCGCTCTGAGTAGAACTTCATGGAGGAACAC GGAGTGACCCAAACCGAACATATGGCTACCATAGAAGCACATGCAGTGGCCCAGCAAGTGCAGCAGGTCCATGTGGCTACTTACACCGAG CATAGTATGCTGAGTGCTGATGAAGACTCGCCTTCTTCTCCCGAGGACACCTCTTACGATGACTCAGATATACTCAACTCCACAGCAGCT GATGAGGTGACAGCTCATCTGGCAGCTGCAGGTCCTGTGGGAATGGCCGCTGCTGCTGCTGTGGCAACAGGAAAGAAACGGAAACGGCCT CATGTATTTGAGTCTAATCCATCTATCCGGAAGAGGCAACAAACACGTTTGCTTCGGAAACTTCGAGCCACGTTAGATGAATATACTACT CGTGTGGGACAGCAAGCTATTGTCCTCTGTATCTCACCCTCCAAACCTAACCCTGTCTTTAAAGTGTTTGGTGCAGCACCTTTGGAGAAT GTGGTGCGTAAGTACAAGAGCATGATCCTGGAAGACCTGGAGTCTGCTCTGGCAGAACACGCCCCTGCGCCACAGGAGGTTAACTCAGAA CTGCCGCCTCTCACCATCGACGGAATTCCAGTCTCTGTGGACAAAATGACCCAGGCCCAGCTTCGGGCATTTATCCCAGAGATGCTCAAG TACTCTACAGGTCGGGGAAAACCAGGCTGGGGGAAAGAAAGCTGCAAGCCCATCTGGTGGCCTGAAGATATCCCCTGGGCAAATGTCCGG AGTGATGTCCGCACAGAAGAGCAAAAGCAGAGGGTTTCATGGACCCAGGCACTACGGACCATAGTTAAAAACTGTTATAAACAGCATGGG CGGGAAGACCTTTTGTATGCCTTTGAAGATCAGCAAACGCAAACACAGGCCACAGCCACACATAGTATAGCTCATCTTGTACCATCACAG ACTGTAGTCCAGACTTTTAGTAACCCTGATGGCACTGTCTCACTTATCCAGGTTGGTACGGGGGCAACAGTAGCCACATTGGCTGATGCT TCAGAATTGCCAACCACGGTCACCGTTGCCCAAGTGAATTATTCTGCCGTGGCTGATGGAGAGGTGGAACAAAATTGGGCCACGTTACAG GGAGGTGAGATGACCATCCAGACGACGCAAGCATCAGAGGCCACCCAGGCGGTGGCATCGTTGGCAGAGGCCGCAGTGGCAGCTTCTCAG GAGATGCAGCAGGGAGCTACAGTCACTATGGCGCTTAACAGCGAAGCTGCCGCCCATGCTGTCGCCACCCTGGCTGAGGCCACCTTACAA GGTGGGGGACAGATCGTCTTGTCTGGGGAAACCGCAGCAGCCGTCGGAGCACTTACTGGAGTCCAAGATGCTAATGGATTTAAGTGCCCT GTATGCTCAAAATTTGTATCCTCAGATGAAATGGATTTGCATCTTGTAATGTGTTTAACAAAGCCACGAATAACCTATAATGAGGATGTA CTGAGTAAAGATGCTGGGGAATGTGCAATATGCCTTGAAGAATTGCAGCAGGGAGATACTATAGCACGACTGCCTTGTCTATGCATATAT CATAAAGGCTGCATAGATGAATGGTTTGAAGTAAATAGATCTTGCCCTGAGCACCCTTCAGATTAAGCGTCAGCTTCCTGTTTTATAGGT TTTCTTGTCTTGACAAGATGCTTGAAAAACCAAGAGGATATGAAAATCTGTCTCTGGAGAAACAAAGACGCAGGCATACTCAGCCAGAAA TCTGAGTTTTGTGAGACTTGGTAATACAGAGATGGACAATCGTACTGGGGTAAAAAAACCCTGCTGAAGAGAGGACAGTGACCACAGAAC TCAGTGTACCAAACATGCATACAAAGGACACACAGGGATTTTGAAAATGCTGCACATCCCTTAATAGTCATCTACATAGGTAATACTGAT AAACATTTTGTATTCAGACGCCAAAGTTAACTGATTTAAAAGTTGATTTACTTTTTATTAAGTTCTCCAGAGCTGCACAACTAGTTATGT TTTGATTTGTTTTGTTTTTTAATTTGGGGTCTCTTTGTTTTCCCCAACATAATGTTCATAATGTTTCTGCATTCATCTGTTCTTAAATTG AAAAACATATAATTTACTTCTTATAAATTGAAGTCTTAAATGTGAAACCAAGAAATGTAATCAAGCAGTAAAAACATCTGAATGTAGACC ATGATCTCAAGTTCTTCCATTTTCTCCCCCACGAGTGGAAAATAGACTTCTACATAGGAAAGCTAAAATATGTTAATATTTTTAAATTAA AGGTTTAATATCAGAATGCAGTCCAAAGAGCAAATCATATTACATAATTACATTTTAATTAAATATAGAATATTCTACTGAATTGCAATT TATTAAATATTCTTATCCTCTTAAATAAAACTGCTCAACAGTTAATCAGCAGTGAATCATCTTGCAGCTATGCAATTTAAAAAAAATACA GATTACCAATTTCAAGTGCTGCCAGCTAAAATAACTGTTTTAACGGGTATCTTTTGTTTGTTCTTTTCACTTAATTATTTTATTGTGCTT TGCATCTCCAGGCAGTTCTCTCACATTTGGGTAAAATGTTTAGCAGGCTGTAAACTTAAGAAAAGGGTAAAATAAAATTTTCTGGAGAGG AACTTGGAATTTGAGGGAGATTTTATATACCTTTAAAAACTGTAATTTAATTGGGATGCCAGGTTTATAGCAATTTGCAACTTTAATTTT CCAGATAATCTGGAGGTTAGCATTTGATAAATGATTTTTTAAAGTAGATATGAAGATTTTGTTAATTTATAATTTATTCATGTGTTATTA CTGTAATTGAAAATGTTATAGACACTTTTAAATTCAGTTTGTGTAGAAAGAAATGTGTTAAACAAAATTATGTTAATAAATATTCCCACA TAATACATCTGAATGGTTAAAAATACTGGAAGAGTTGTCAGGGCTACAATAGTGAATGTCCTTTTTTTTAATATCAAAAATATCGATAAG TAGGTTTTGTGTTTTCAACGTAGGGAAAATGTTATCAGTGAATAGGTGGTGTACTTTACTTGGTATAATTTAAAGTTGCACAGTAAGTAC TGTTTCCTTATTTTAATCTTTCTTTACTCATAATGTATTTAAGAATTTGCTGTTTTATTTAACGCTGCTACTCTTAATCTTCTCTAAATT TTTCCCCCTACTTTCTTGCTTCTGTTTCACATTTTTTAAAAGGGCAAGTACAGGAGCAACTGCTGCTACCCAGAAAAATGTGTGTATTAT >60271_60271_2_NRF1-ZNRF2_NRF1_chr7_129367205_ENST00000311967_ZNRF2_chr7_30363258_ENST00000323037_length(amino acids)=535AA_BP=449 MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSADEDSPSSPEDTSYDDSDILNSTAADEVTAHLAAAGPVGMAAAAAVATGKK RKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLENVVRKYKSMILEDLESALAEHAPAPQE VNSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQRVSWTQALRTIVKNCY KQHGREDLLYAFEDQQTQTQATATHSIAHLVPSQTVVQTFSNPDGTVSLIQVGTGATVATLADASELPTTVTVAQVNYSAVADGEVEQNW ATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQQGATVTMALNSEAAAHAVATLAEATLQGGGQIVLSGETAAAVGALTGVQDANG -------------------------------------------------------------- >60271_60271_3_NRF1-ZNRF2_NRF1_chr7_129367205_ENST00000353868_ZNRF2_chr7_30363258_ENST00000323037_length(transcript)=3207nt_BP=1267nt GGCGGCAGAAGCGGCAGCGCTCGCCATTGCCGCTGGTGGCAGGAGGCTGCGAGGAGCCGGCGCGGTCGCAGTCTCCACGGCGCAGGCCCA CGGTAGCGCAGCCGCTCTGAGAACTTCATGGAGGAACACGGAGTGACCCAAACCGAACATATGGCTACCATAGAAGCACATGCAGTGGCC CAGCAAGTGCAGCAGGTCCATGTGGCTACTTACACCGAGCATAGTATGCTGAGTGCTGATGAAGACTCGCCTTCTTCTCCCGAGGACACC TCTTACGATGACTCAGATATACTCAACTCCACAGCAGCTGATGAGGTGACAGCTCATCTGGCAGCTGCAGGTCCTGTGGGAATGGCCGCT GCTGCTGCTGTGGCAACAGGAAAGAAACGGAAACGGCCTCATGTATTTGAGTCTAATCCATCTATCCGGAAGAGGCAACAAACACGTTTG CTTCGGAAACTTCGAGCCACGTTAGATGAATATACTACTCGTGTGGGACAGCAAGCTATTGTCCTCTGTATCTCACCCTCCAAACCTAAC CCTGTCTTTAAAGTGTTTGGTGCAGCACCTTTGGAGAATGTGGTGCGTAAGTACAAGAGCATGATCCTGGAAGACCTGGAGTCTGCTCTG GCAGAACACGCCCCTGCGCCACAGGAGGTTAACTCAGAACTGCCGCCTCTCACCATCGACGGAATTCCAGTCTCTGTGGACAAAATGACC CAGGCCCAGCTTCGGGCATTTATCCCAGAGATGCTCAAGTACTCTACAGGTCGGGGAAAACCAGGCTGGGGGAAAGAAAGCTGCAAGCCC ATCTGGTGGCCTGAAGATATCCCCTGGGCAAATGTCCGGAGTGATGTCCGCACAGAAGAGCAAAAGCAGAGGGTTGGTACGGGGGCAACA GTAGCCACATTGGCTGATGCTTCAGAATTGCCAACCACGGTCACCGTTGCCCAAGTGAATTATTCTGCCGTGGCTGATGGAGAGGTGGAA CAAAATTGGGCCACGTTACAGGGAGGTGAGATGACCATCCAGACGACGCAAGCATCAGAGGCCACCCAGGCGGTGGCATCGTTGGCAGAG GCCGCAGTGGCAGCTTCTCAGGAGATGCAGCAGGGAGCTACAGTCACTATGGCGCTTAACAGCGAAGCTGCCGCCCATGCTGTCGCCACC CTGGCTGAGGCCACCTTACAAGGTGGGGGACAGATCGTCTTGTCTGGGGAAACCGCAGCAGCCGTCGGAGCACTTACTGGAGTCCAAGAT GCTAATGGATTTAAGTGCCCTGTATGCTCAAAATTTGTATCCTCAGATGAAATGGATTTGCATCTTGTAATGTGTTTAACAAAGCCACGA ATAACCTATAATGAGGATGTACTGAGTAAAGATGCTGGGGAATGTGCAATATGCCTTGAAGAATTGCAGCAGGGAGATACTATAGCACGA CTGCCTTGTCTATGCATATATCATAAAGGCTGCATAGATGAATGGTTTGAAGTAAATAGATCTTGCCCTGAGCACCCTTCAGATTAAGCG TCAGCTTCCTGTTTTATAGGTTTTCTTGTCTTGACAAGATGCTTGAAAAACCAAGAGGATATGAAAATCTGTCTCTGGAGAAACAAAGAC GCAGGCATACTCAGCCAGAAATCTGAGTTTTGTGAGACTTGGTAATACAGAGATGGACAATCGTACTGGGGTAAAAAAACCCTGCTGAAG AGAGGACAGTGACCACAGAACTCAGTGTACCAAACATGCATACAAAGGACACACAGGGATTTTGAAAATGCTGCACATCCCTTAATAGTC ATCTACATAGGTAATACTGATAAACATTTTGTATTCAGACGCCAAAGTTAACTGATTTAAAAGTTGATTTACTTTTTATTAAGTTCTCCA GAGCTGCACAACTAGTTATGTTTTGATTTGTTTTGTTTTTTAATTTGGGGTCTCTTTGTTTTCCCCAACATAATGTTCATAATGTTTCTG CATTCATCTGTTCTTAAATTGAAAAACATATAATTTACTTCTTATAAATTGAAGTCTTAAATGTGAAACCAAGAAATGTAATCAAGCAGT AAAAACATCTGAATGTAGACCATGATCTCAAGTTCTTCCATTTTCTCCCCCACGAGTGGAAAATAGACTTCTACATAGGAAAGCTAAAAT ATGTTAATATTTTTAAATTAAAGGTTTAATATCAGAATGCAGTCCAAAGAGCAAATCATATTACATAATTACATTTTAATTAAATATAGA ATATTCTACTGAATTGCAATTTATTAAATATTCTTATCCTCTTAAATAAAACTGCTCAACAGTTAATCAGCAGTGAATCATCTTGCAGCT ATGCAATTTAAAAAAAATACAGATTACCAATTTCAAGTGCTGCCAGCTAAAATAACTGTTTTAACGGGTATCTTTTGTTTGTTCTTTTCA CTTAATTATTTTATTGTGCTTTGCATCTCCAGGCAGTTCTCTCACATTTGGGTAAAATGTTTAGCAGGCTGTAAACTTAAGAAAAGGGTA AAATAAAATTTTCTGGAGAGGAACTTGGAATTTGAGGGAGATTTTATATACCTTTAAAAACTGTAATTTAATTGGGATGCCAGGTTTATA GCAATTTGCAACTTTAATTTTCCAGATAATCTGGAGGTTAGCATTTGATAAATGATTTTTTAAAGTAGATATGAAGATTTTGTTAATTTA TAATTTATTCATGTGTTATTACTGTAATTGAAAATGTTATAGACACTTTTAAATTCAGTTTGTGTAGAAAGAAATGTGTTAAACAAAATT ATGTTAATAAATATTCCCACATAATACATCTGAATGGTTAAAAATACTGGAAGAGTTGTCAGGGCTACAATAGTGAATGTCCTTTTTTTT AATATCAAAAATATCGATAAGTAGGTTTTGTGTTTTCAACGTAGGGAAAATGTTATCAGTGAATAGGTGGTGTACTTTACTTGGTATAAT TTAAAGTTGCACAGTAAGTACTGTTTCCTTATTTTAATCTTTCTTTACTCATAATGTATTTAAGAATTTGCTGTTTTATTTAACGCTGCT ACTCTTAATCTTCTCTAAATTTTTCCCCCTACTTTCTTGCTTCTGTTTCACATTTTTTAAAAGGGCAAGTACAGGAGCAACTGCTGCTAC >60271_60271_3_NRF1-ZNRF2_NRF1_chr7_129367205_ENST00000353868_ZNRF2_chr7_30363258_ENST00000323037_length(amino acids)=469AA_BP=383 MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSADEDSPSSPEDTSYDDSDILNSTAADEVTAHLAAAGPVGMAAAAAVATGKK RKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLENVVRKYKSMILEDLESALAEHAPAPQE VNSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQRVGTGATVATLADASE LPTTVTVAQVNYSAVADGEVEQNWATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQQGATVTMALNSEAAAHAVATLAEATLQGG GQIVLSGETAAAVGALTGVQDANGFKCPVCSKFVSSDEMDLHLVMCLTKPRITYNEDVLSKDAGECAICLEELQQGDTIARLPCLCIYHK -------------------------------------------------------------- >60271_60271_4_NRF1-ZNRF2_NRF1_chr7_129367205_ENST00000393230_ZNRF2_chr7_30363258_ENST00000323037_length(transcript)=3398nt_BP=1458nt CCCCTTTCAGTTCCTGGTCCAGAACTTTACACAGAAAAGGTGCTCAAAGGATATTTGTTTAATGAATGTGGTATGCTGACATTTAAACAG GACAAAACTTGTAGAACTTCATGGAGGAACACGGAGTGACCCAAACCGAACATATGGCTACCATAGAAGCACATGCAGTGGCCCAGCAAG TGCAGCAGGTCCATGTGGCTACTTACACCGAGCATAGTATGCTGAGTGCTGATGAAGACTCGCCTTCTTCTCCCGAGGACACCTCTTACG ATGACTCAGATATACTCAACTCCACAGCAGCTGATGAGGTGACAGCTCATCTGGCAGCTGCAGGTCCTGTGGGAATGGCCGCTGCTGCTG CTGTGGCAACAGGAAAGAAACGGAAACGGCCTCATGTATTTGAGTCTAATCCATCTATCCGGAAGAGGCAACAAACACGTTTGCTTCGGA AACTTCGAGCCACGTTAGATGAATATACTACTCGTGTGGGACAGCAAGCTATTGTCCTCTGTATCTCACCCTCCAAACCTAACCCTGTCT TTAAAGTGTTTGGTGCAGCACCTTTGGAGAATGTGGTGCGTAAGTACAAGAGCATGATCCTGGAAGACCTGGAGTCTGCTCTGGCAGAAC ACGCCCCTGCGCCACAGGAGGTTAACTCAGAACTGCCGCCTCTCACCATCGACGGAATTCCAGTCTCTGTGGACAAAATGACCCAGGCCC AGCTTCGGGCATTTATCCCAGAGATGCTCAAGTACTCTACAGGTCGGGGAAAACCAGGCTGGGGGAAAGAAAGCTGCAAGCCCATCTGGT GGCCTGAAGATATCCCCTGGGCAAATGTCCGGAGTGATGTCCGCACAGAAGAGCAAAAGCAGAGGGTTTCATGGACCCAGGCACTACGGA CCATAGTTAAAAACTGTTATAAACAGCATGGGCGGGAAGACCTTTTGTATGCCTTTGAAGATCAGCAAACGCAAACACAGGCCACAGCCA CACATAGTATAGCTCATCTTGTACCATCACAGACTGTAGTCCAGACTTTTAGTAACCCTGATGGCACTGTCTCACTTATCCAGGTTGGTA CGGGGGCAACAGTAGCCACATTGGCTGATGCTTCAGAATTGCCAACCACGGTCACCGTTGCCCAAGTGAATTATTCTGCCGTGGCTGATG GAGAGGTGGAACAAAATTGGGCCACGTTACAGGGAGGTGAGATGACCATCCAGACGACGCAAGCATCAGAGGCCACCCAGGCGGTGGCAT CGTTGGCAGAGGCCGCAGTGGCAGCTTCTCAGGAGATGCAGCAGGGAGCTACAGTCACTATGGCGCTTAACAGCGAAGCTGCCGCCCATG CTGTCGCCACCCTGGCTGAGGCCACCTTACAAGGTGGGGGACAGATCGTCTTGTCTGGGGAAACCGCAGCAGCCGTCGGAGCACTTACTG GAGTCCAAGATGCTAATGGATTTAAGTGCCCTGTATGCTCAAAATTTGTATCCTCAGATGAAATGGATTTGCATCTTGTAATGTGTTTAA CAAAGCCACGAATAACCTATAATGAGGATGTACTGAGTAAAGATGCTGGGGAATGTGCAATATGCCTTGAAGAATTGCAGCAGGGAGATA CTATAGCACGACTGCCTTGTCTATGCATATATCATAAAGGCTGCATAGATGAATGGTTTGAAGTAAATAGATCTTGCCCTGAGCACCCTT CAGATTAAGCGTCAGCTTCCTGTTTTATAGGTTTTCTTGTCTTGACAAGATGCTTGAAAAACCAAGAGGATATGAAAATCTGTCTCTGGA GAAACAAAGACGCAGGCATACTCAGCCAGAAATCTGAGTTTTGTGAGACTTGGTAATACAGAGATGGACAATCGTACTGGGGTAAAAAAA CCCTGCTGAAGAGAGGACAGTGACCACAGAACTCAGTGTACCAAACATGCATACAAAGGACACACAGGGATTTTGAAAATGCTGCACATC CCTTAATAGTCATCTACATAGGTAATACTGATAAACATTTTGTATTCAGACGCCAAAGTTAACTGATTTAAAAGTTGATTTACTTTTTAT TAAGTTCTCCAGAGCTGCACAACTAGTTATGTTTTGATTTGTTTTGTTTTTTAATTTGGGGTCTCTTTGTTTTCCCCAACATAATGTTCA TAATGTTTCTGCATTCATCTGTTCTTAAATTGAAAAACATATAATTTACTTCTTATAAATTGAAGTCTTAAATGTGAAACCAAGAAATGT AATCAAGCAGTAAAAACATCTGAATGTAGACCATGATCTCAAGTTCTTCCATTTTCTCCCCCACGAGTGGAAAATAGACTTCTACATAGG AAAGCTAAAATATGTTAATATTTTTAAATTAAAGGTTTAATATCAGAATGCAGTCCAAAGAGCAAATCATATTACATAATTACATTTTAA TTAAATATAGAATATTCTACTGAATTGCAATTTATTAAATATTCTTATCCTCTTAAATAAAACTGCTCAACAGTTAATCAGCAGTGAATC ATCTTGCAGCTATGCAATTTAAAAAAAATACAGATTACCAATTTCAAGTGCTGCCAGCTAAAATAACTGTTTTAACGGGTATCTTTTGTT TGTTCTTTTCACTTAATTATTTTATTGTGCTTTGCATCTCCAGGCAGTTCTCTCACATTTGGGTAAAATGTTTAGCAGGCTGTAAACTTA AGAAAAGGGTAAAATAAAATTTTCTGGAGAGGAACTTGGAATTTGAGGGAGATTTTATATACCTTTAAAAACTGTAATTTAATTGGGATG CCAGGTTTATAGCAATTTGCAACTTTAATTTTCCAGATAATCTGGAGGTTAGCATTTGATAAATGATTTTTTAAAGTAGATATGAAGATT TTGTTAATTTATAATTTATTCATGTGTTATTACTGTAATTGAAAATGTTATAGACACTTTTAAATTCAGTTTGTGTAGAAAGAAATGTGT TAAACAAAATTATGTTAATAAATATTCCCACATAATACATCTGAATGGTTAAAAATACTGGAAGAGTTGTCAGGGCTACAATAGTGAATG TCCTTTTTTTTAATATCAAAAATATCGATAAGTAGGTTTTGTGTTTTCAACGTAGGGAAAATGTTATCAGTGAATAGGTGGTGTACTTTA CTTGGTATAATTTAAAGTTGCACAGTAAGTACTGTTTCCTTATTTTAATCTTTCTTTACTCATAATGTATTTAAGAATTTGCTGTTTTAT TTAACGCTGCTACTCTTAATCTTCTCTAAATTTTTCCCCCTACTTTCTTGCTTCTGTTTCACATTTTTTAAAAGGGCAAGTACAGGAGCA >60271_60271_4_NRF1-ZNRF2_NRF1_chr7_129367205_ENST00000393230_ZNRF2_chr7_30363258_ENST00000323037_length(amino acids)=535AA_BP=449 MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSADEDSPSSPEDTSYDDSDILNSTAADEVTAHLAAAGPVGMAAAAAVATGKK RKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLENVVRKYKSMILEDLESALAEHAPAPQE VNSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQRVSWTQALRTIVKNCY KQHGREDLLYAFEDQQTQTQATATHSIAHLVPSQTVVQTFSNPDGTVSLIQVGTGATVATLADASELPTTVTVAQVNYSAVADGEVEQNW ATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQQGATVTMALNSEAAAHAVATLAEATLQGGGQIVLSGETAAAVGALTGVQDANG -------------------------------------------------------------- >60271_60271_5_NRF1-ZNRF2_NRF1_chr7_129367205_ENST00000393231_ZNRF2_chr7_30363258_ENST00000323037_length(transcript)=3289nt_BP=1349nt CATGGAGGAACACGGAGTGACCCAAACCGAACATATGGCTACCATAGAAGCACATGCAGTGGCCCAGCAAGTGCAGCAGGTCCATGTGGC TACTTACACCGAGCATAGTATGCTGAGTGCTGATGAAGACTCGCCTTCTTCTCCCGAGGACACCTCTTACGATGACTCAGATATACTCAA CTCCACAGCAGCTGATGAGGTGACAGCTCATCTGGCAGCTGCAGGTCCTGTGGGAATGGCCGCTGCTGCTGCTGTGGCAACAGGAAAGAA ACGGAAACGGCCTCATGTATTTGAGTCTAATCCATCTATCCGGAAGAGGCAACAAACACGTTTGCTTCGGAAACTTCGAGCCACGTTAGA TGAATATACTACTCGTGTGGGACAGCAAGCTATTGTCCTCTGTATCTCACCCTCCAAACCTAACCCTGTCTTTAAAGTGTTTGGTGCAGC ACCTTTGGAGAATGTGGTGCGTAAGTACAAGAGCATGATCCTGGAAGACCTGGAGTCTGCTCTGGCAGAACACGCCCCTGCGCCACAGGA GGTTAACTCAGAACTGCCGCCTCTCACCATCGACGGAATTCCAGTCTCTGTGGACAAAATGACCCAGGCCCAGCTTCGGGCATTTATCCC AGAGATGCTCAAGTACTCTACAGGTCGGGGAAAACCAGGCTGGGGGAAAGAAAGCTGCAAGCCCATCTGGTGGCCTGAAGATATCCCCTG GGCAAATGTCCGGAGTGATGTCCGCACAGAAGAGCAAAAGCAGAGGGTTTCATGGACCCAGGCACTACGGACCATAGTTAAAAACTGTTA TAAACAGCATGGGCGGGAAGACCTTTTGTATGCCTTTGAAGATCAGCAAACGCAAACACAGGCCACAGCCACACATAGTATAGCTCATCT TGTACCATCACAGACTGTAGTCCAGACTTTTAGTAACCCTGATGGCACTGTCTCACTTATCCAGGTTGGTACGGGGGCAACAGTAGCCAC ATTGGCTGATGCTTCAGAATTGCCAACCACGGTCACCGTTGCCCAAGTGAATTATTCTGCCGTGGCTGATGGAGAGGTGGAACAAAATTG GGCCACGTTACAGGGAGGTGAGATGACCATCCAGACGACGCAAGCATCAGAGGCCACCCAGGCGGTGGCATCGTTGGCAGAGGCCGCAGT GGCAGCTTCTCAGGAGATGCAGCAGGGAGCTACAGTCACTATGGCGCTTAACAGCGAAGCTGCCGCCCATGCTGTCGCCACCCTGGCTGA GGCCACCTTACAAGGTGGGGGACAGATCGTCTTGTCTGGGGAAACCGCAGCAGCCGTCGGAGCACTTACTGGAGTCCAAGATGCTAATGG ATTTAAGTGCCCTGTATGCTCAAAATTTGTATCCTCAGATGAAATGGATTTGCATCTTGTAATGTGTTTAACAAAGCCACGAATAACCTA TAATGAGGATGTACTGAGTAAAGATGCTGGGGAATGTGCAATATGCCTTGAAGAATTGCAGCAGGGAGATACTATAGCACGACTGCCTTG TCTATGCATATATCATAAAGGCTGCATAGATGAATGGTTTGAAGTAAATAGATCTTGCCCTGAGCACCCTTCAGATTAAGCGTCAGCTTC CTGTTTTATAGGTTTTCTTGTCTTGACAAGATGCTTGAAAAACCAAGAGGATATGAAAATCTGTCTCTGGAGAAACAAAGACGCAGGCAT ACTCAGCCAGAAATCTGAGTTTTGTGAGACTTGGTAATACAGAGATGGACAATCGTACTGGGGTAAAAAAACCCTGCTGAAGAGAGGACA GTGACCACAGAACTCAGTGTACCAAACATGCATACAAAGGACACACAGGGATTTTGAAAATGCTGCACATCCCTTAATAGTCATCTACAT AGGTAATACTGATAAACATTTTGTATTCAGACGCCAAAGTTAACTGATTTAAAAGTTGATTTACTTTTTATTAAGTTCTCCAGAGCTGCA CAACTAGTTATGTTTTGATTTGTTTTGTTTTTTAATTTGGGGTCTCTTTGTTTTCCCCAACATAATGTTCATAATGTTTCTGCATTCATC TGTTCTTAAATTGAAAAACATATAATTTACTTCTTATAAATTGAAGTCTTAAATGTGAAACCAAGAAATGTAATCAAGCAGTAAAAACAT CTGAATGTAGACCATGATCTCAAGTTCTTCCATTTTCTCCCCCACGAGTGGAAAATAGACTTCTACATAGGAAAGCTAAAATATGTTAAT ATTTTTAAATTAAAGGTTTAATATCAGAATGCAGTCCAAAGAGCAAATCATATTACATAATTACATTTTAATTAAATATAGAATATTCTA CTGAATTGCAATTTATTAAATATTCTTATCCTCTTAAATAAAACTGCTCAACAGTTAATCAGCAGTGAATCATCTTGCAGCTATGCAATT TAAAAAAAATACAGATTACCAATTTCAAGTGCTGCCAGCTAAAATAACTGTTTTAACGGGTATCTTTTGTTTGTTCTTTTCACTTAATTA TTTTATTGTGCTTTGCATCTCCAGGCAGTTCTCTCACATTTGGGTAAAATGTTTAGCAGGCTGTAAACTTAAGAAAAGGGTAAAATAAAA TTTTCTGGAGAGGAACTTGGAATTTGAGGGAGATTTTATATACCTTTAAAAACTGTAATTTAATTGGGATGCCAGGTTTATAGCAATTTG CAACTTTAATTTTCCAGATAATCTGGAGGTTAGCATTTGATAAATGATTTTTTAAAGTAGATATGAAGATTTTGTTAATTTATAATTTAT TCATGTGTTATTACTGTAATTGAAAATGTTATAGACACTTTTAAATTCAGTTTGTGTAGAAAGAAATGTGTTAAACAAAATTATGTTAAT AAATATTCCCACATAATACATCTGAATGGTTAAAAATACTGGAAGAGTTGTCAGGGCTACAATAGTGAATGTCCTTTTTTTTAATATCAA AAATATCGATAAGTAGGTTTTGTGTTTTCAACGTAGGGAAAATGTTATCAGTGAATAGGTGGTGTACTTTACTTGGTATAATTTAAAGTT GCACAGTAAGTACTGTTTCCTTATTTTAATCTTTCTTTACTCATAATGTATTTAAGAATTTGCTGTTTTATTTAACGCTGCTACTCTTAA TCTTCTCTAAATTTTTCCCCCTACTTTCTTGCTTCTGTTTCACATTTTTTAAAAGGGCAAGTACAGGAGCAACTGCTGCTACCCAGAAAA >60271_60271_5_NRF1-ZNRF2_NRF1_chr7_129367205_ENST00000393231_ZNRF2_chr7_30363258_ENST00000323037_length(amino acids)=535AA_BP=449 MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSADEDSPSSPEDTSYDDSDILNSTAADEVTAHLAAAGPVGMAAAAAVATGKK RKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLENVVRKYKSMILEDLESALAEHAPAPQE VNSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQRVSWTQALRTIVKNCY KQHGREDLLYAFEDQQTQTQATATHSIAHLVPSQTVVQTFSNPDGTVSLIQVGTGATVATLADASELPTTVTVAQVNYSAVADGEVEQNW ATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQQGATVTMALNSEAAAHAVATLAEATLQGGGQIVLSGETAAAVGALTGVQDANG -------------------------------------------------------------- >60271_60271_6_NRF1-ZNRF2_NRF1_chr7_129367205_ENST00000393232_ZNRF2_chr7_30363258_ENST00000323037_length(transcript)=3405nt_BP=1465nt GGCGGCAGAAGCGGCAGCGCTCGCCATTGCCGCTGGTGGCAGGAGGCTGCGAGGAGCCGGCGCGGTCGCAGTCTCCACGGCGCAGGCCCA CGGTAGCGCAGCCGCTCTGAGAACTTCATGGAGGAACACGGAGTGACCCAAACCGAACATATGGCTACCATAGAAGCACATGCAGTGGCC CAGCAAGTGCAGCAGGTCCATGTGGCTACTTACACCGAGCATAGTATGCTGAGTGCTGATGAAGACTCGCCTTCTTCTCCCGAGGACACC TCTTACGATGACTCAGATATACTCAACTCCACAGCAGCTGATGAGGTGACAGCTCATCTGGCAGCTGCAGGTCCTGTGGGAATGGCCGCT GCTGCTGCTGTGGCAACAGGAAAGAAACGGAAACGGCCTCATGTATTTGAGTCTAATCCATCTATCCGGAAGAGGCAACAAACACGTTTG CTTCGGAAACTTCGAGCCACGTTAGATGAATATACTACTCGTGTGGGACAGCAAGCTATTGTCCTCTGTATCTCACCCTCCAAACCTAAC CCTGTCTTTAAAGTGTTTGGTGCAGCACCTTTGGAGAATGTGGTGCGTAAGTACAAGAGCATGATCCTGGAAGACCTGGAGTCTGCTCTG GCAGAACACGCCCCTGCGCCACAGGAGGTTAACTCAGAACTGCCGCCTCTCACCATCGACGGAATTCCAGTCTCTGTGGACAAAATGACC CAGGCCCAGCTTCGGGCATTTATCCCAGAGATGCTCAAGTACTCTACAGGTCGGGGAAAACCAGGCTGGGGGAAAGAAAGCTGCAAGCCC ATCTGGTGGCCTGAAGATATCCCCTGGGCAAATGTCCGGAGTGATGTCCGCACAGAAGAGCAAAAGCAGAGGGTTTCATGGACCCAGGCA CTACGGACCATAGTTAAAAACTGTTATAAACAGCATGGGCGGGAAGACCTTTTGTATGCCTTTGAAGATCAGCAAACGCAAACACAGGCC ACAGCCACACATAGTATAGCTCATCTTGTACCATCACAGACTGTAGTCCAGACTTTTAGTAACCCTGATGGCACTGTCTCACTTATCCAG GTTGGTACGGGGGCAACAGTAGCCACATTGGCTGATGCTTCAGAATTGCCAACCACGGTCACCGTTGCCCAAGTGAATTATTCTGCCGTG GCTGATGGAGAGGTGGAACAAAATTGGGCCACGTTACAGGGAGGTGAGATGACCATCCAGACGACGCAAGCATCAGAGGCCACCCAGGCG GTGGCATCGTTGGCAGAGGCCGCAGTGGCAGCTTCTCAGGAGATGCAGCAGGGAGCTACAGTCACTATGGCGCTTAACAGCGAAGCTGCC GCCCATGCTGTCGCCACCCTGGCTGAGGCCACCTTACAAGGTGGGGGACAGATCGTCTTGTCTGGGGAAACCGCAGCAGCCGTCGGAGCA CTTACTGGAGTCCAAGATGCTAATGGATTTAAGTGCCCTGTATGCTCAAAATTTGTATCCTCAGATGAAATGGATTTGCATCTTGTAATG TGTTTAACAAAGCCACGAATAACCTATAATGAGGATGTACTGAGTAAAGATGCTGGGGAATGTGCAATATGCCTTGAAGAATTGCAGCAG GGAGATACTATAGCACGACTGCCTTGTCTATGCATATATCATAAAGGCTGCATAGATGAATGGTTTGAAGTAAATAGATCTTGCCCTGAG CACCCTTCAGATTAAGCGTCAGCTTCCTGTTTTATAGGTTTTCTTGTCTTGACAAGATGCTTGAAAAACCAAGAGGATATGAAAATCTGT CTCTGGAGAAACAAAGACGCAGGCATACTCAGCCAGAAATCTGAGTTTTGTGAGACTTGGTAATACAGAGATGGACAATCGTACTGGGGT AAAAAAACCCTGCTGAAGAGAGGACAGTGACCACAGAACTCAGTGTACCAAACATGCATACAAAGGACACACAGGGATTTTGAAAATGCT GCACATCCCTTAATAGTCATCTACATAGGTAATACTGATAAACATTTTGTATTCAGACGCCAAAGTTAACTGATTTAAAAGTTGATTTAC TTTTTATTAAGTTCTCCAGAGCTGCACAACTAGTTATGTTTTGATTTGTTTTGTTTTTTAATTTGGGGTCTCTTTGTTTTCCCCAACATA ATGTTCATAATGTTTCTGCATTCATCTGTTCTTAAATTGAAAAACATATAATTTACTTCTTATAAATTGAAGTCTTAAATGTGAAACCAA GAAATGTAATCAAGCAGTAAAAACATCTGAATGTAGACCATGATCTCAAGTTCTTCCATTTTCTCCCCCACGAGTGGAAAATAGACTTCT ACATAGGAAAGCTAAAATATGTTAATATTTTTAAATTAAAGGTTTAATATCAGAATGCAGTCCAAAGAGCAAATCATATTACATAATTAC ATTTTAATTAAATATAGAATATTCTACTGAATTGCAATTTATTAAATATTCTTATCCTCTTAAATAAAACTGCTCAACAGTTAATCAGCA GTGAATCATCTTGCAGCTATGCAATTTAAAAAAAATACAGATTACCAATTTCAAGTGCTGCCAGCTAAAATAACTGTTTTAACGGGTATC TTTTGTTTGTTCTTTTCACTTAATTATTTTATTGTGCTTTGCATCTCCAGGCAGTTCTCTCACATTTGGGTAAAATGTTTAGCAGGCTGT AAACTTAAGAAAAGGGTAAAATAAAATTTTCTGGAGAGGAACTTGGAATTTGAGGGAGATTTTATATACCTTTAAAAACTGTAATTTAAT TGGGATGCCAGGTTTATAGCAATTTGCAACTTTAATTTTCCAGATAATCTGGAGGTTAGCATTTGATAAATGATTTTTTAAAGTAGATAT GAAGATTTTGTTAATTTATAATTTATTCATGTGTTATTACTGTAATTGAAAATGTTATAGACACTTTTAAATTCAGTTTGTGTAGAAAGA AATGTGTTAAACAAAATTATGTTAATAAATATTCCCACATAATACATCTGAATGGTTAAAAATACTGGAAGAGTTGTCAGGGCTACAATA GTGAATGTCCTTTTTTTTAATATCAAAAATATCGATAAGTAGGTTTTGTGTTTTCAACGTAGGGAAAATGTTATCAGTGAATAGGTGGTG TACTTTACTTGGTATAATTTAAAGTTGCACAGTAAGTACTGTTTCCTTATTTTAATCTTTCTTTACTCATAATGTATTTAAGAATTTGCT GTTTTATTTAACGCTGCTACTCTTAATCTTCTCTAAATTTTTCCCCCTACTTTCTTGCTTCTGTTTCACATTTTTTAAAAGGGCAAGTAC >60271_60271_6_NRF1-ZNRF2_NRF1_chr7_129367205_ENST00000393232_ZNRF2_chr7_30363258_ENST00000323037_length(amino acids)=535AA_BP=449 MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSADEDSPSSPEDTSYDDSDILNSTAADEVTAHLAAAGPVGMAAAAAVATGKK RKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLENVVRKYKSMILEDLESALAEHAPAPQE VNSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQRVSWTQALRTIVKNCY KQHGREDLLYAFEDQQTQTQATATHSIAHLVPSQTVVQTFSNPDGTVSLIQVGTGATVATLADASELPTTVTVAQVNYSAVADGEVEQNW ATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQQGATVTMALNSEAAAHAVATLAEATLQGGGQIVLSGETAAAVGALTGVQDANG -------------------------------------------------------------- >60271_60271_7_NRF1-ZNRF2_NRF1_chr7_129367205_ENST00000539636_ZNRF2_chr7_30363258_ENST00000323037_length(transcript)=3268nt_BP=1328nt ATTGCCGCTGGTGGCAGGAGGCTGCGAGGAGCCGGCGCGGTCGCAGTCTCCACGGCGCAGGCCCACGGTAGCGCAGCCGCTCTGAGTAGA ACTTCATGGAGGAACACGGAGTGACCCAAACCGAACATATGGCTACCATAGAAGCACATGCAGTGGCCCAGCAAGTGCAGCAGGTCCATG TGGCTACTTACACCGAGCATAGTATGCTGAGTGCTGATGAAGACTCGCCTTCTTCTCCCGAGGACACCTCTTACGATGACTCAGATATAC TCAACTCCACAGCAGCTGATGAGGTGACAGCTCATCTGGCAGCTGCAGGAAACTTCGAGCCACGTTAGATGAATATACTACTCGTGTGGG ACAGCAAGCTATTGTCCTCTGTATCTCACCCTCCAAACCTAACCCTGTCTTTAAAGTGTTTGGTGCAGCACCTTTGGAGAATGTGGTGCG TAAGTACAAGAGCATGATCCTGGAAGACCTGGAGTCTGCTCTGGCAGAACACGCCCCTGCGCCACAGGAGGTTAACTCAGAACTGCCGCC TCTCACCATCGACGGAATTCCAGTCTCTGTGGACAAAATGACCCAGGCCCAGCTTCGGGCATTTATCCCAGAGATGCTCAAGTACTCTAC AGGTCGGGGAAAACCAGGCTGGGGGAAAGAAAGCTGCAAGCCCATCTGGTGGCCTGAAGATATCCCCTGGGCAAATGTCCGGAGTGATGT CCGCACAGAAGAGCAAAAGCAGAGGGTTTCATGGACCCAGGCACTACGGACCATAGTTAAAAACTGTTATAAACAGCATGGGCGGGAAGA CCTTTTGTATGCCTTTGAAGATCAGCAAACGCAAACACAGGCCACAGCCACACATAGTATAGCTCATCTTGTACCATCACAGACTGTAGT CCAGACTTTTAGTAACCCTGATGGCACTGTCTCACTTATCCAGGTTGGTACGGGGGCAACAGTAGCCACATTGGCTGATGCTTCAGAATT GCCAACCACGGTCACCGTTGCCCAAGTGAATTATTCTGCCGTGGCTGATGGAGAGGTGGAACAAAATTGGGCCACGTTACAGGGAGGTGA GATGACCATCCAGACGACGCAAGCATCAGAGGCCACCCAGGCGGTGGCATCGTTGGCAGAGGCCGCAGTGGCAGCTTCTCAGGAGATGCA GCAGGGAGCTACAGTCACTATGGCGCTTAACAGCGAAGCTGCCGCCCATGCTGTCGCCACCCTGGCTGAGGCCACCTTACAAGGTGGGGG ACAGATCGTCTTGTCTGGGGAAACCGCAGCAGCCGTCGGAGCACTTACTGGAGTCCAAGATGCTAATGGATTTAAGTGCCCTGTATGCTC AAAATTTGTATCCTCAGATGAAATGGATTTGCATCTTGTAATGTGTTTAACAAAGCCACGAATAACCTATAATGAGGATGTACTGAGTAA AGATGCTGGGGAATGTGCAATATGCCTTGAAGAATTGCAGCAGGGAGATACTATAGCACGACTGCCTTGTCTATGCATATATCATAAAGG CTGCATAGATGAATGGTTTGAAGTAAATAGATCTTGCCCTGAGCACCCTTCAGATTAAGCGTCAGCTTCCTGTTTTATAGGTTTTCTTGT CTTGACAAGATGCTTGAAAAACCAAGAGGATATGAAAATCTGTCTCTGGAGAAACAAAGACGCAGGCATACTCAGCCAGAAATCTGAGTT TTGTGAGACTTGGTAATACAGAGATGGACAATCGTACTGGGGTAAAAAAACCCTGCTGAAGAGAGGACAGTGACCACAGAACTCAGTGTA CCAAACATGCATACAAAGGACACACAGGGATTTTGAAAATGCTGCACATCCCTTAATAGTCATCTACATAGGTAATACTGATAAACATTT TGTATTCAGACGCCAAAGTTAACTGATTTAAAAGTTGATTTACTTTTTATTAAGTTCTCCAGAGCTGCACAACTAGTTATGTTTTGATTT GTTTTGTTTTTTAATTTGGGGTCTCTTTGTTTTCCCCAACATAATGTTCATAATGTTTCTGCATTCATCTGTTCTTAAATTGAAAAACAT ATAATTTACTTCTTATAAATTGAAGTCTTAAATGTGAAACCAAGAAATGTAATCAAGCAGTAAAAACATCTGAATGTAGACCATGATCTC AAGTTCTTCCATTTTCTCCCCCACGAGTGGAAAATAGACTTCTACATAGGAAAGCTAAAATATGTTAATATTTTTAAATTAAAGGTTTAA TATCAGAATGCAGTCCAAAGAGCAAATCATATTACATAATTACATTTTAATTAAATATAGAATATTCTACTGAATTGCAATTTATTAAAT ATTCTTATCCTCTTAAATAAAACTGCTCAACAGTTAATCAGCAGTGAATCATCTTGCAGCTATGCAATTTAAAAAAAATACAGATTACCA ATTTCAAGTGCTGCCAGCTAAAATAACTGTTTTAACGGGTATCTTTTGTTTGTTCTTTTCACTTAATTATTTTATTGTGCTTTGCATCTC CAGGCAGTTCTCTCACATTTGGGTAAAATGTTTAGCAGGCTGTAAACTTAAGAAAAGGGTAAAATAAAATTTTCTGGAGAGGAACTTGGA ATTTGAGGGAGATTTTATATACCTTTAAAAACTGTAATTTAATTGGGATGCCAGGTTTATAGCAATTTGCAACTTTAATTTTCCAGATAA TCTGGAGGTTAGCATTTGATAAATGATTTTTTAAAGTAGATATGAAGATTTTGTTAATTTATAATTTATTCATGTGTTATTACTGTAATT GAAAATGTTATAGACACTTTTAAATTCAGTTTGTGTAGAAAGAAATGTGTTAAACAAAATTATGTTAATAAATATTCCCACATAATACAT CTGAATGGTTAAAAATACTGGAAGAGTTGTCAGGGCTACAATAGTGAATGTCCTTTTTTTTAATATCAAAAATATCGATAAGTAGGTTTT GTGTTTTCAACGTAGGGAAAATGTTATCAGTGAATAGGTGGTGTACTTTACTTGGTATAATTTAAAGTTGCACAGTAAGTACTGTTTCCT TATTTTAATCTTTCTTTACTCATAATGTATTTAAGAATTTGCTGTTTTATTTAACGCTGCTACTCTTAATCTTCTCTAAATTTTTCCCCC TACTTTCTTGCTTCTGTTTCACATTTTTTAAAAGGGCAAGTACAGGAGCAACTGCTGCTACCCAGAAAAATGTGTGTATTATAAATAATT >60271_60271_7_NRF1-ZNRF2_NRF1_chr7_129367205_ENST00000539636_ZNRF2_chr7_30363258_ENST00000323037_length(amino acids)=384AA_BP=298 MENVVRKYKSMILEDLESALAEHAPAPQEVNSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWA NVRSDVRTEEQKQRVSWTQALRTIVKNCYKQHGREDLLYAFEDQQTQTQATATHSIAHLVPSQTVVQTFSNPDGTVSLIQVGTGATVATL ADASELPTTVTVAQVNYSAVADGEVEQNWATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQQGATVTMALNSEAAAHAVATLAEA TLQGGGQIVLSGETAAAVGALTGVQDANGFKCPVCSKFVSSDEMDLHLVMCLTKPRITYNEDVLSKDAGECAICLEELQQGDTIARLPCL -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for NRF1-ZNRF2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for NRF1-ZNRF2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for NRF1-ZNRF2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies