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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NRG1-NRG1 (FusionGDB2 ID:60276)

Fusion Gene Summary for NRG1-NRG1

Fusion gene summary

Fusion gene information	Fusion gene name: NRG1-NRG1
	Fusion gene ID: 60276
		Hgene	Tgene
	Gene symbol	NRG1	NRG1
	Gene ID	3084	3084
	Gene name	neuregulin 1	neuregulin 1
	Synonyms	ARIA\|GGF\|GGF2\|HGL\|HRG\|HRG1\|HRGA\|MST131\|MSTP131\|NDF\|NRG1-IT2\|SMDF	ARIA\|GGF\|GGF2\|HGL\|HRG\|HRG1\|HRGA\|MST131\|MSTP131\|NDF\|NRG1-IT2\|SMDF
	Cytomap	8p12	8p12
	Type of gene	protein-coding	protein-coding
	Description	pro-neuregulin-1, membrane-bound isoformacetylcholine receptor-inducing activityglial growth factor 2heregulin, alpha (45kD, ERBB2 p185-activator)neu differentiation factorpro-NRG1sensory and motor neuron derived factor	pro-neuregulin-1, membrane-bound isoformacetylcholine receptor-inducing activityglial growth factor 2heregulin, alpha (45kD, ERBB2 p185-activator)neu differentiation factorpro-NRG1sensory and motor neuron derived factor
	Modification date	20200320	20200320
	UniProtAcc	Q02297	Q02297
	Ensembl transtripts involved in fusion gene	ENST00000519301, ENST00000287842, ENST00000287845, ENST00000338921, ENST00000341377, ENST00000356819, ENST00000405005, ENST00000520407, ENST00000520502, ENST00000521670, ENST00000523079, ENST00000523681, ENST00000539990,	ENST00000520502, ENST00000523681, ENST00000539990, ENST00000287842, ENST00000287845, ENST00000338921, ENST00000341377, ENST00000356819, ENST00000405005, ENST00000519301, ENST00000520407, ENST00000521670, ENST00000523079,
Fusion gene scores	* DoF score	12 X 10 X 7=840	25 X 17 X 14=5950
	# samples	12	27
	** MAII score	log2(12/840*10)=-2.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(27/5950*10)=-4.46185835603184 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NRG1 [Title/Abstract] AND NRG1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NRG1(31496947)-NRG1(32453344), # samples:13
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NRG1	GO:0003222	ventricular trabecula myocardium morphogenesis	17336907
Hgene	NRG1	GO:0031334	positive regulation of protein complex assembly	10559227
Hgene	NRG1	GO:0038127	ERBB signaling pathway	11389077
Hgene	NRG1	GO:0038129	ERBB3 signaling pathway	27353365
Hgene	NRG1	GO:0045892	negative regulation of transcription, DNA-templated	15073182
Hgene	NRG1	GO:0051048	negative regulation of secretion	10559227
Hgene	NRG1	GO:0060379	cardiac muscle cell myoblast differentiation	17336907
Hgene	NRG1	GO:0060956	endocardial cell differentiation	17336907
Tgene	NRG1	GO:0003222	ventricular trabecula myocardium morphogenesis	17336907
Tgene	NRG1	GO:0031334	positive regulation of protein complex assembly	10559227
Tgene	NRG1	GO:0038127	ERBB signaling pathway	11389077
Tgene	NRG1	GO:0038129	ERBB3 signaling pathway	27353365
Tgene	NRG1	GO:0045892	negative regulation of transcription, DNA-templated	15073182
Tgene	NRG1	GO:0051048	negative regulation of secretion	10559227
Tgene	NRG1	GO:0060379	cardiac muscle cell myoblast differentiation	17336907
Tgene	NRG1	GO:0060956	endocardial cell differentiation	17336907

Fusion gene breakpoints across NRG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NRG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	EF372273	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
ChiTaRS5.0	N/A	EF372274	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
ChiTaRS5.0	N/A	EF372275	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
ChiTaRS5.0	N/A	EF372276	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
ChiTaRS5.0	N/A	EF372277	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
ChiTaRS5.0	N/A	EF517295	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
ChiTaRS5.0	N/A	EF517296	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
ChiTaRS5.0	N/A	EF517297	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
ChiTaRS5.0	N/A	NM_001159995	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
ChiTaRS5.0	N/A	NM_001159999	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
ChiTaRS5.0	N/A	NM_001160001	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
ChiTaRS5.0	N/A	NM_001322201	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
ChiTaRS5.0	N/A	NM_001322202	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+

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Fusion Gene ORF analysis for NRG1-NRG1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000519301	ENST00000520502	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
5CDS-intron	ENST00000519301	ENST00000523681	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
5CDS-intron	ENST00000519301	ENST00000539990	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
In-frame	ENST00000519301	ENST00000287842	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
In-frame	ENST00000519301	ENST00000287845	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
In-frame	ENST00000519301	ENST00000338921	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
In-frame	ENST00000519301	ENST00000341377	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
In-frame	ENST00000519301	ENST00000356819	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
In-frame	ENST00000519301	ENST00000405005	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
In-frame	ENST00000519301	ENST00000519301	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
In-frame	ENST00000519301	ENST00000520407	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
In-frame	ENST00000519301	ENST00000521670	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
In-frame	ENST00000519301	ENST00000523079	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000287842	ENST00000287842	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000287842	ENST00000287845	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000287842	ENST00000338921	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000287842	ENST00000341377	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000287842	ENST00000356819	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000287842	ENST00000405005	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000287842	ENST00000519301	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000287842	ENST00000520407	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000287842	ENST00000521670	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000287842	ENST00000523079	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000287845	ENST00000287842	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000287845	ENST00000287845	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000287845	ENST00000338921	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000287845	ENST00000341377	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000287845	ENST00000356819	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000287845	ENST00000405005	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000287845	ENST00000519301	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000287845	ENST00000520407	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000287845	ENST00000521670	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000287845	ENST00000523079	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000338921	ENST00000287842	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000338921	ENST00000287845	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000338921	ENST00000338921	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000338921	ENST00000341377	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000338921	ENST00000356819	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000338921	ENST00000405005	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000338921	ENST00000519301	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000338921	ENST00000520407	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000338921	ENST00000521670	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000338921	ENST00000523079	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000341377	ENST00000287842	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000341377	ENST00000287845	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000341377	ENST00000338921	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000341377	ENST00000341377	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000341377	ENST00000356819	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000341377	ENST00000405005	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000341377	ENST00000519301	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000341377	ENST00000520407	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000341377	ENST00000521670	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000341377	ENST00000523079	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000356819	ENST00000287842	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000356819	ENST00000287845	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000356819	ENST00000338921	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000356819	ENST00000341377	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000356819	ENST00000356819	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000356819	ENST00000405005	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000356819	ENST00000519301	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000356819	ENST00000520407	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000356819	ENST00000521670	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000356819	ENST00000523079	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000405005	ENST00000287842	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000405005	ENST00000287845	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000405005	ENST00000338921	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000405005	ENST00000341377	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000405005	ENST00000356819	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000405005	ENST00000405005	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000405005	ENST00000519301	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000405005	ENST00000520407	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000405005	ENST00000521670	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000405005	ENST00000523079	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000520407	ENST00000287842	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000520407	ENST00000287845	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000520407	ENST00000338921	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000520407	ENST00000341377	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000520407	ENST00000356819	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000520407	ENST00000405005	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000520407	ENST00000519301	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000520407	ENST00000520407	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000520407	ENST00000521670	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000520407	ENST00000523079	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000520502	ENST00000287842	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000520502	ENST00000287845	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000520502	ENST00000338921	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000520502	ENST00000341377	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000520502	ENST00000356819	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000520502	ENST00000405005	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000520502	ENST00000519301	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000520502	ENST00000520407	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000520502	ENST00000521670	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000520502	ENST00000523079	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000521670	ENST00000287842	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000521670	ENST00000287845	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000521670	ENST00000338921	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000521670	ENST00000341377	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000521670	ENST00000356819	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000521670	ENST00000405005	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000521670	ENST00000519301	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000521670	ENST00000520407	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000521670	ENST00000521670	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000521670	ENST00000523079	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000523079	ENST00000287842	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000523079	ENST00000287845	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000523079	ENST00000338921	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000523079	ENST00000341377	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000523079	ENST00000356819	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000523079	ENST00000405005	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000523079	ENST00000519301	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000523079	ENST00000520407	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000523079	ENST00000521670	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000523079	ENST00000523079	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000523681	ENST00000287842	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000523681	ENST00000287845	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000523681	ENST00000338921	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000523681	ENST00000341377	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000523681	ENST00000356819	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000523681	ENST00000405005	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000523681	ENST00000519301	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000523681	ENST00000520407	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000523681	ENST00000521670	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000523681	ENST00000523079	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000539990	ENST00000287842	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000539990	ENST00000287845	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000539990	ENST00000338921	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000539990	ENST00000341377	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000539990	ENST00000356819	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000539990	ENST00000405005	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000539990	ENST00000519301	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000539990	ENST00000520407	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000539990	ENST00000521670	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-3CDS	ENST00000539990	ENST00000523079	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000287842	ENST00000520502	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000287842	ENST00000523681	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000287842	ENST00000539990	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000287845	ENST00000520502	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000287845	ENST00000523681	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000287845	ENST00000539990	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000338921	ENST00000520502	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000338921	ENST00000523681	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000338921	ENST00000539990	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000341377	ENST00000520502	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000341377	ENST00000523681	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000341377	ENST00000539990	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000356819	ENST00000520502	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000356819	ENST00000523681	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000356819	ENST00000539990	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000405005	ENST00000520502	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000405005	ENST00000523681	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000405005	ENST00000539990	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000520407	ENST00000520502	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000520407	ENST00000523681	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000520407	ENST00000539990	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000520502	ENST00000520502	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000520502	ENST00000523681	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000520502	ENST00000539990	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000521670	ENST00000520502	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000521670	ENST00000523681	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000521670	ENST00000539990	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000523079	ENST00000520502	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000523079	ENST00000523681	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000523079	ENST00000539990	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000523681	ENST00000520502	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000523681	ENST00000523681	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000523681	ENST00000539990	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000539990	ENST00000520502	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000539990	ENST00000523681	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+
intron-intron	ENST00000539990	ENST00000539990	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000519301	NRG1	chr8	31496947	+	ENST00000519301	NRG1	chr8	32453344	+	1785	46	9	1781	590
ENST00000519301	NRG1	chr8	31496947	+	ENST00000520407	NRG1	chr8	32453344	+	1026	46	9	569	186
ENST00000519301	NRG1	chr8	31496947	+	ENST00000523079	NRG1	chr8	32453344	+	1788	46	9	1208	399
ENST00000519301	NRG1	chr8	31496947	+	ENST00000338921	NRG1	chr8	32453344	+	2521	46	9	1892	627
ENST00000519301	NRG1	chr8	31496947	+	ENST00000356819	NRG1	chr8	32453344	+	2512	46	9	1883	624
ENST00000519301	NRG1	chr8	31496947	+	ENST00000287845	NRG1	chr8	32453344	+	2410	46	9	1781	590
ENST00000519301	NRG1	chr8	31496947	+	ENST00000341377	NRG1	chr8	32453344	+	2556	46	689	1927	412
ENST00000519301	NRG1	chr8	31496947	+	ENST00000287842	NRG1	chr8	32453344	+	1969	46	9	1859	616
ENST00000519301	NRG1	chr8	31496947	+	ENST00000521670	NRG1	chr8	32453344	+	1607	46	9	1334	441
ENST00000519301	NRG1	chr8	31496947	+	ENST00000405005	NRG1	chr8	32453344	+	1938	46	9	1868	619

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000519301	ENST00000519301	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+	0.012085608	0.9879144
ENST00000519301	ENST00000520407	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+	0.004736614	0.99526334
ENST00000519301	ENST00000523079	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+	0.006751682	0.99324834
ENST00000519301	ENST00000338921	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+	0.004683498	0.9953165
ENST00000519301	ENST00000356819	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+	0.003776387	0.99622357
ENST00000519301	ENST00000287845	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+	0.00392518	0.9960748
ENST00000519301	ENST00000341377	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+	0.004885315	0.9951147
ENST00000519301	ENST00000287842	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+	0.007732549	0.99226743
ENST00000519301	ENST00000521670	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+	0.031561658	0.9684383
ENST00000519301	ENST00000405005	NRG1	chr8	31496947	+	NRG1	chr8	32453344	+	0.010651933	0.98934805

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Fusion Genomic Features for NRG1-NRG1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
NRG1	chr8	31496947	+	NRG1	chr8	32453345	+	0.9971923	0.002807661
NRG1	chr8	31496947	+	NRG1	chr8	32453345	+	0.9971923	0.002807661

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NRG1-NRG1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:31496947/chr8:32453344)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NRG1 Q02297	NRG1 Q02297
FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity). {ECO:0000250\|UniProtKB:P43322, ECO:0000269\|PubMed:10867024, ECO:0000269\|PubMed:1348215, ECO:0000269\|PubMed:20682778, ECO:0000269\|PubMed:7902537}.	FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity). {ECO:0000250\|UniProtKB:P43322, ECO:0000269\|PubMed:10867024, ECO:0000269\|PubMed:1348215, ECO:0000269\|PubMed:20682778, ECO:0000269\|PubMed:7902537}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000287842

165_177

638.0

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000341377

165_177

525.3333333333334

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000356819

165_177

646.0

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000405005

165_177

641.0

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000519301

165_177

591.0

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000520502

165_177

297.0

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000521670

165_177

477.3333333333333

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000523079

165_177

421.0

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000287842

178_222

638.0

Domain

EGF-like

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000287842

37_128

638.0

Domain

Note=Ig-like C2-type

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000341377

178_222

525.3333333333334

Domain

EGF-like

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000341377

37_128

525.3333333333334

Domain

Note=Ig-like C2-type

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000356819

178_222

646.0

Domain

EGF-like

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000356819

37_128

646.0

Domain

Note=Ig-like C2-type

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000405005

178_222

641.0

Domain

EGF-like

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000405005

37_128

641.0

Domain

Note=Ig-like C2-type

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000519301

178_222

591.0

Domain

EGF-like

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000519301

37_128

591.0

Domain

Note=Ig-like C2-type

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000520502

178_222

297.0

Domain

EGF-like

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000520502

37_128

297.0

Domain

Note=Ig-like C2-type

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000521670

178_222

477.3333333333333

Domain

EGF-like

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000521670

37_128

477.3333333333333

Domain

Note=Ig-like C2-type

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000523079

178_222

421.0

Domain

EGF-like

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000523079

37_128

421.0

Domain

Note=Ig-like C2-type

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000287842

266_640

638.0

Topological domain

Cytoplasmic

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000341377

266_640

525.3333333333334

Topological domain

Cytoplasmic

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000356819

266_640

646.0

Topological domain

Cytoplasmic

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000405005

266_640

641.0

Topological domain

Cytoplasmic

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000519301

20_242

591.0

Topological domain

Extracellular

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000519301

266_640

591.0

Topological domain

Cytoplasmic

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000520407

266_640

248

423.0

Topological domain

Cytoplasmic

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000520502

20_242

297.0

Topological domain

Extracellular

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000520502

266_640

297.0

Topological domain

Cytoplasmic

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000521670

266_640

477.3333333333333

Topological domain

Cytoplasmic

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000523079

266_640

421.0

Topological domain

Cytoplasmic

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000287842

243_265

638.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000341377

243_265

525.3333333333334

Transmembrane

Helical%3B Note%3DInternal signal sequence

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000356819

243_265

646.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000405005

243_265

641.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000519301

243_265

591.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000520502

243_265

297.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000521670

243_265

477.3333333333333

Transmembrane

Helical%3B Note%3DInternal signal sequence

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000523079

243_265

421.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000287842

165_177

638.0

Compositional bias

Note=Ser/Thr-rich

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000341377

165_177

525.3333333333334

Compositional bias

Note=Ser/Thr-rich

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000356819

165_177

646.0

Compositional bias

Note=Ser/Thr-rich

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000405005

165_177

641.0

Compositional bias

Note=Ser/Thr-rich

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000519301

165_177

591.0

Compositional bias

Note=Ser/Thr-rich

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000520407

165_177

423.0

Compositional bias

Note=Ser/Thr-rich

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000520502

165_177

297.0

Compositional bias

Note=Ser/Thr-rich

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000521670

165_177

477.3333333333333

Compositional bias

Note=Ser/Thr-rich

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000523079

165_177

421.0

Compositional bias

Note=Ser/Thr-rich

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000287842

178_222

638.0

Domain

EGF-like

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000287842

37_128

638.0

Domain

Note=Ig-like C2-type

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000341377

178_222

525.3333333333334

Domain

EGF-like

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000341377

37_128

525.3333333333334

Domain

Note=Ig-like C2-type

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000356819

178_222

646.0

Domain

EGF-like

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000356819

37_128

646.0

Domain

Note=Ig-like C2-type

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000405005

178_222

641.0

Domain

EGF-like

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000405005

37_128

641.0

Domain

Note=Ig-like C2-type

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000519301

178_222

591.0

Domain

EGF-like

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000519301

37_128

591.0

Domain

Note=Ig-like C2-type

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000520407

178_222

423.0

Domain

EGF-like

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000520407

37_128

423.0

Domain

Note=Ig-like C2-type

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000520502

178_222

297.0

Domain

EGF-like

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000520502

37_128

297.0

Domain

Note=Ig-like C2-type

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000521670

178_222

477.3333333333333

Domain

EGF-like

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000521670

37_128

477.3333333333333

Domain

Note=Ig-like C2-type

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000523079

178_222

421.0

Domain

EGF-like

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000523079

37_128

421.0

Domain

Note=Ig-like C2-type

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000287842

20_242

638.0

Topological domain

Extracellular

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000287842

266_640

638.0

Topological domain

Cytoplasmic

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000341377

20_242

525.3333333333334

Topological domain

Extracellular

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000341377

266_640

525.3333333333334

Topological domain

Cytoplasmic

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000356819

20_242

646.0

Topological domain

Extracellular

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000356819

266_640

646.0

Topological domain

Cytoplasmic

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000405005

20_242

641.0

Topological domain

Extracellular

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000405005

266_640

641.0

Topological domain

Cytoplasmic

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000519301

20_242

591.0

Topological domain

Extracellular

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000519301

266_640

591.0

Topological domain

Cytoplasmic

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000520407

20_242

423.0

Topological domain

Extracellular

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000520407

266_640

423.0

Topological domain

Cytoplasmic

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000520502

20_242

297.0

Topological domain

Extracellular

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000520502

266_640

297.0

Topological domain

Cytoplasmic

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000521670

20_242

477.3333333333333

Topological domain

Extracellular

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000521670

266_640

477.3333333333333

Topological domain

Cytoplasmic

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000523079

20_242

421.0

Topological domain

Extracellular

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000523079

266_640

421.0

Topological domain

Cytoplasmic

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000287842

243_265

638.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000341377

243_265

525.3333333333334

Transmembrane

Helical%3B Note%3DInternal signal sequence

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000356819

243_265

646.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000405005

243_265

641.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000519301

243_265

591.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000520407

243_265

423.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000520502

243_265

297.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000521670

243_265

477.3333333333333

Transmembrane

Helical%3B Note%3DInternal signal sequence

Hgene

NRG1

chr8:31496947

chr8:32453344

ENST00000523079

243_265

421.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000520407

165_177

248

423.0

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000520407

178_222

248

423.0

Domain

EGF-like

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000520407

37_128

248

423.0

Domain

Note=Ig-like C2-type

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000287842

20_242

638.0

Topological domain

Extracellular

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000341377

20_242

525.3333333333334

Topological domain

Extracellular

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000356819

20_242

646.0

Topological domain

Extracellular

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000405005

20_242

641.0

Topological domain

Extracellular

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000520407

20_242

248

423.0

Topological domain

Extracellular

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000521670

20_242

477.3333333333333

Topological domain

Extracellular

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000523079

20_242

421.0

Topological domain

Extracellular

Tgene

NRG1

chr8:31496947

chr8:32453344

ENST00000520407

243_265

248

423.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Top

Fusion Gene Sequence for NRG1-NRG1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>60276_60276_1_NRG1-NRG1_NRG1_chr8_31496947_ENST00000519301_NRG1_chr8_32453344_ENST00000287842_length(transcript)=1969nt_BP=46nt
GGCAGCAGCATGGGGAAAGGACGCGCGGGCCGAGTTGGCACCACAGCCTTGCCTCCCCGATTGAAAGAGATGAAAAGCCAGGAATCGGCT
GCAGGTTCCAAACTAGTCCTTCGGTGTGAAACCAGTTCTGAATACTCCTCTCTCAGATTCAAGTGGTTCAAGAATGGGAATGAATTGAAT
CGAAAAAACAAACCACAAAATATCAAGATACAAAAAAAGCCAGGGAAGTCAGAACTTCGCATTAACAAAGCATCACTGGCTGATTCTGGA
GAGTATATGTGCAAAGTGATCAGCAAATTAGGAAATGACAGTGCCTCTGCCAATATCACCATCGTGGAATCAAACGAGATCATCACTGGT
ATGCCAGCCTCAACTGAAGGAGCATATGTGTCTTCAGAGTCTCCCATTAGAATATCAGTATCCACAGAAGGAGCAAATACTTCTTCATCT
ACATCTACATCCACCACTGGGACAAGCCATCTTGTAAAATGTGCGGAGAAGGAGAAAACTTTCTGTGTGAATGGAGGGGAGTGCTTCATG
GTGAAAGACCTTTCAAACCCCTCGAGATACTTGTGCAAGTGCCCAAATGAGTTTACTGGTGATCGCTGCCAAAACTACGTAATGGCCAGC
TTCTACAAGGCGGAGGAGCTGTACCAGAAGAGAGTGCTGACCATAACCGGCATCTGCATCGCCCTCCTTGTGGTCGGCATCATGTGTGTG
GTGGCCTACTGCAAAACCAAGAAACAGCGGAAAAAGCTGCATGACCGTCTTCGGCAGAGCCTTCGGTCTGAACGAAACAATATGATGAAC
ATTGCCAATGGGCCTCACCATCCTAACCCACCCCCCGAGAATGTCCAGCTGGTGAATCAATACGTATCTAAAAACGTCATCTCCAGTGAG
CATATTGTTGAGAGAGAAGCAGAGACATCCTTTTCCACCAGTCACTATACTTCCACAGCCCATCACTCCACTACTGTCACCCAGACTCCT
AGCCACAGCTGGAGCAACGGACACACTGAAAGCATCCTTTCCGAAAGCCACTCTGTAATCGTGATGTCATCCGTAGAAAACAGTAGGCAC
AGCAGCCCAACTGGGGGCCCAAGAGGACGTCTTAATGGCACAGGAGGCCCTCGTGAATGTAACAGCTTCCTCAGGCATGCCAGAGAAACC
CCTGATTCCTACCGAGACTCTCCTCATAGTGAAAGGTATGTGTCAGCCATGACCACCCCGGCTCGTATGTCACCTGTAGATTTCCACACG
CCAAGCTCCCCCAAATCGCCCCCTTCGGAAATGTCTCCACCCGTGTCCAGCATGACGGTGTCCATGCCTTCCATGGCGGTCAGCCCCTTC
ATGGAAGAAGAGAGACCTCTACTTCTCGTGACACCACCAAGGCTGCGGGAGAAGAAGTTTGACCATCACCCTCAGCAGTTCAGCTCCTTC
CACCACAACCCCGCGCATGACAGTAACAGCCTCCCTGCTAGCCCCTTGAGGATAGTGGAGGATGAGGAGTATGAAACGACCCAAGAGTAC
GAGCCAGCCCAAGAGCCTGTTAAGAAACTCGCCAATAGCCGGCGGGCCAAAAGAACCAAGCCCAATGGCCACATTGCTAACAGATTGGAA
GTGGACAGCAACACAAGCTCCCAGAGCAGTAACTCAGAGAGTGAAACAGAAGATGAAAGAGTAGGTGAAGATACGCCTTTCCTGGGCATA
CAGAACCCCCTGGCAGCCAGTCTTGAGGCAACACCTGCCTTCCGCCTGGCTGACAGCAGGACTAACCCAGCAGGCCGCTTCTCGACACAG
GAAGAAATCCAGGCCAGGCTGTCTAGTGTAATTGCTAACCAAGACCCTATTGCTGTATAAAACCTAAATAAACACATAGATTCACCTGTA

>60276_60276_1_NRG1-NRG1_NRG1_chr8_31496947_ENST00000519301_NRG1_chr8_32453344_ENST00000287842_length(amino acids)=616AA_BP=12
MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM
CKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD
LSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIAN
GPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSP
TGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEE
ERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDS

--------------------------------------------------------------
>60276_60276_2_NRG1-NRG1_NRG1_chr8_31496947_ENST00000519301_NRG1_chr8_32453344_ENST00000287845_length(transcript)=2410nt_BP=46nt
GGCAGCAGCATGGGGAAAGGACGCGCGGGCCGAGTTGGCACCACAGCCTTGCCTCCCCGATTGAAAGAGATGAAAAGCCAGGAATCGGCT
GCAGGTTCCAAACTAGTCCTTCGGTGTGAAACCAGTTCTGAATACTCCTCTCTCAGATTCAAGTGGTTCAAGAATGGGAATGAATTGAAT
CGAAAAAACAAACCACAAAATATCAAGATACAAAAAAAGCCAGGGAAGTCAGAACTTCGCATTAACAAAGCATCACTGGCTGATTCTGGA
GAGTATATGTGCAAAGTGATCAGCAAATTAGGAAATGACAGTGCCTCTGCCAATATCACCATCGTGGAATCAAACGCTACATCTACATCC
ACCACTGGGACAAGCCATCTTGTAAAATGTGCGGAGAAGGAGAAAACTTTCTGTGTGAATGGAGGGGAGTGCTTCATGGTGAAAGACCTT
TCAAACCCCTCGAGATACTTGTGCAAGTGCCCAAATGAGTTTACTGGTGATCGCTGCCAAAACTACGTAATGGCCAGCTTCTACAAGCAT
CTTGGGATTGAATTTATGGAGGCGGAGGAGCTGTACCAGAAGAGAGTGCTGACCATAACCGGCATCTGCATCGCCCTCCTTGTGGTCGGC
ATCATGTGTGTGGTGGCCTACTGCAAAACCAAGAAACAGCGGAAAAAGCTGCATGACCGTCTTCGGCAGAGCCTTCGGTCTGAACGAAAC
AATATGATGAACATTGCCAATGGGCCTCACCATCCTAACCCACCCCCCGAGAATGTCCAGCTGGTGAATCAATACGTATCTAAAAACGTC
ATCTCCAGTGAGCATATTGTTGAGAGAGAAGCAGAGACATCCTTTTCCACCAGTCACTATACTTCCACAGCCCATCACTCCACTACTGTC
ACCCAGACTCCTAGCCACAGCTGGAGCAACGGACACACTGAAAGCATCCTTTCCGAAAGCCACTCTGTAATCGTGATGTCATCCGTAGAA
AACAGTAGGCACAGCAGCCCAACTGGGGGCCCAAGAGGACGTCTTAATGGCACAGGAGGCCCTCGTGAATGTAACAGCTTCCTCAGGCAT
GCCAGAGAAACCCCTGATTCCTACCGAGACTCTCCTCATAGTGAAAGGTATGTGTCAGCCATGACCACCCCGGCTCGTATGTCACCTGTA
GATTTCCACACGCCAAGCTCCCCCAAATCGCCCCCTTCGGAAATGTCTCCACCCGTGTCCAGCATGACGGTGTCCATGCCTTCCATGGCG
GTCAGCCCCTTCATGGAAGAAGAGAGACCTCTACTTCTCGTGACACCACCAAGGCTGCGGGAGAAGAAGTTTGACCATCACCCTCAGCAG
TTCAGCTCCTTCCACCACAACCCCGCGCATGACAGTAACAGCCTCCCTGCTAGCCCCTTGAGGATAGTGGAGGATGAGGAGTATGAAACG
ACCCAAGAGTACGAGCCAGCCCAAGAGCCTGTTAAGAAACTCGCCAATAGCCGGCGGGCCAAAAGAACCAAGCCCAATGGCCACATTGCT
AACAGATTGGAAGTGGACAGCAACACAAGCTCCCAGAGCAGTAACTCAGAGAGTGAAACAGAAGATGAAAGAGTAGGTGAAGATACGCCT
TTCCTGGGCATACAGAACCCCCTGGCAGCCAGTCTTGAGGCAACACCTGCCTTCCGCCTGGCTGACAGCAGGACTAACCCAGCAGGCCGC
TTCTCGACACAGGAAGAAATCCAGGCCAGGCTGTCTAGTGTAATTGCTAACCAAGACCCTATTGCTGTATAAAACCTAAATAAACACATA
GATTCACCTGTAAAACTTTATTTTATATAATAAAGTATTCCACCTTAAATTAAACAATTTATTTTATTTTAGCAGTTCTGCAAATAGAAA
ACAGGAAAAAAACTTTTATAAATTAAATATATGTATGTAAAAATGTGTTATGTGCCATATGTAGCAATTTTTTACAGTATTTCAAAACGA
GAAAGATATCAATGGTGCCTTTATGTTATGTTATGTCGAGAGCAAGTTTTGTACAGTTACAGTGATTGCTTTTCCACAGTATTTCTGCAA
AACCTCTCATAGATTCAGTTTTTGCTGGCTTCTTGTGCATTGCATTATGATGTTGACTGGATGTATGATTTGCAAGACTTGCAACTGTCC
CTCTGTTTGCTTGTAGTAGCACCCGATCAGTATGTCTTGTAATGGCACATCCATCCAGATATGCCTCTCTTGTGTATGAAGTTTTCTTTG
CTTTCAGAATATGAAATGAGTTGTGTCTACTCTGCCAGCCAAAGGTTTGCCTCATTGGGCTCTGAGATAATAGTAGATCCAACAGCATGC

>60276_60276_2_NRG1-NRG1_NRG1_chr8_31496947_ENST00000519301_NRG1_chr8_32453344_ENST00000287845_length(amino acids)=590AA_BP=12
MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM
CKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGI
EFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISS
EHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARE
TPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSS
FHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLG

--------------------------------------------------------------
>60276_60276_3_NRG1-NRG1_NRG1_chr8_31496947_ENST00000519301_NRG1_chr8_32453344_ENST00000338921_length(transcript)=2521nt_BP=46nt
GGCAGCAGCATGGGGAAAGGACGCGCGGGCCGAGTTGGCACCACAGCCTTGCCTCCCCGATTGAAAGAGATGAAAAGCCAGGAATCGGCT
GCAGGTTCCAAACTAGTCCTTCGGTGTGAAACCAGTTCTGAATACTCCTCTCTCAGATTCAAGTGGTTCAAGAATGGGAATGAATTGAAT
CGAAAAAACAAACCACAAAATATCAAGATACAAAAAAAGCCAGGGAAGTCAGAACTTCGCATTAACAAAGCATCACTGGCTGATTCTGGA
GAGTATATGTGCAAAGTGATCAGCAAATTAGGAAATGACAGTGCCTCTGCCAATATCACCATCGTGGAATCAAACGAGATCATCACTGGT
ATGCCAGCCTCAACTGAAGGAGCATATGTGTCTTCAGAGTCTCCCATTAGAATATCAGTATCCACAGAAGGAGCAAATACTTCTTCATCT
ACATCTACATCCACCACTGGGACAAGCCATCTTGTAAAATGTGCGGAGAAGGAGAAAACTTTCTGTGTGAATGGAGGGGAGTGCTTCATG
GTGAAAGACCTTTCAAACCCCTCGAGATACTTGTGCAAGTGCCAACCTGGATTCACTGGAGCAAGATGTACTGAGAATGTGCCCATGAAA
GTCCAAAACCAAGAAAAGCATTCTGGAGAACCCTTTCCAGAGGCGGAGGAGCTGTACCAGAAGAGAGTGCTGACCATAACCGGCATCTGC
ATCGCCCTCCTTGTGGTCGGCATCATGTGTGTGGTGGCCTACTGCAAAACCAAGAAACAGCGGAAAAAGCTGCATGACCGTCTTCGGCAG
AGCCTTCGGTCTGAACGAAACAATATGATGAACATTGCCAATGGGCCTCACCATCCTAACCCACCCCCCGAGAATGTCCAGCTGGTGAAT
CAATACGTATCTAAAAACGTCATCTCCAGTGAGCATATTGTTGAGAGAGAAGCAGAGACATCCTTTTCCACCAGTCACTATACTTCCACA
GCCCATCACTCCACTACTGTCACCCAGACTCCTAGCCACAGCTGGAGCAACGGACACACTGAAAGCATCCTTTCCGAAAGCCACTCTGTA
ATCGTGATGTCATCCGTAGAAAACAGTAGGCACAGCAGCCCAACTGGGGGCCCAAGAGGACGTCTTAATGGCACAGGAGGCCCTCGTGAA
TGTAACAGCTTCCTCAGGCATGCCAGAGAAACCCCTGATTCCTACCGAGACTCTCCTCATAGTGAAAGGTATGTGTCAGCCATGACCACC
CCGGCTCGTATGTCACCTGTAGATTTCCACACGCCAAGCTCCCCCAAATCGCCCCCTTCGGAAATGTCTCCACCCGTGTCCAGCATGACG
GTGTCCATGCCTTCCATGGCGGTCAGCCCCTTCATGGAAGAAGAGAGACCTCTACTTCTCGTGACACCACCAAGGCTGCGGGAGAAGAAG
TTTGACCATCACCCTCAGCAGTTCAGCTCCTTCCACCACAACCCCGCGCATGACAGTAACAGCCTCCCTGCTAGCCCCTTGAGGATAGTG
GAGGATGAGGAGTATGAAACGACCCAAGAGTACGAGCCAGCCCAAGAGCCTGTTAAGAAACTCGCCAATAGCCGGCGGGCCAAAAGAACC
AAGCCCAATGGCCACATTGCTAACAGATTGGAAGTGGACAGCAACACAAGCTCCCAGAGCAGTAACTCAGAGAGTGAAACAGAAGATGAA
AGAGTAGGTGAAGATACGCCTTTCCTGGGCATACAGAACCCCCTGGCAGCCAGTCTTGAGGCAACACCTGCCTTCCGCCTGGCTGACAGC
AGGACTAACCCAGCAGGCCGCTTCTCGACACAGGAAGAAATCCAGGCCAGGCTGTCTAGTGTAATTGCTAACCAAGACCCTATTGCTGTA
TAAAACCTAAATAAACACATAGATTCACCTGTAAAACTTTATTTTATATAATAAAGTATTCCACCTTAAATTAAACAATTTATTTTATTT
TAGCAGTTCTGCAAATAGAAAACAGGAAAAAAACTTTTATAAATTAAATATATGTATGTAAAAATGTGTTATGTGCCATATGTAGCAATT
TTTTACAGTATTTCAAAACGAGAAAGATATCAATGGTGCCTTTATGTTATGTTATGTCGAGAGCAAGTTTTGTACAGTTACAGTGATTGC
TTTTCCACAGTATTTCTGCAAAACCTCTCATAGATTCAGTTTTTGCTGGCTTCTTGTGCATTGCATTATGATGTTGACTGGATGTATGAT
TTGCAAGACTTGCAACTGTCCCTCTGTTTGCTTGTAGTAGCACCCGATCAGTATGTCTTGTAATGGCACATCCATCCAGATATGCCTCTC
TTGTGTATGAAGTTTTCTTTGCTTTCAGAATATGAAATGAGTTGTGTCTACTCTGCCAGCCAAAGGTTTGCCTCATTGGGCTCTGAGATA
ATAGTAGATCCAACAGCATGCTACTATTAAATACAGCAAGAAACTGCATTAAGTAATGTTAAATATTAGGAAGAAAGTAATACTGTGATT

>60276_60276_3_NRG1-NRG1_NRG1_chr8_31496947_ENST00000519301_NRG1_chr8_32453344_ENST00000338921_length(amino acids)=627AA_BP=12
MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM
CKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD
LSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKHSGEPFPEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLR
SERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVM
SSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSM
PSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPN

--------------------------------------------------------------
>60276_60276_4_NRG1-NRG1_NRG1_chr8_31496947_ENST00000519301_NRG1_chr8_32453344_ENST00000341377_length(transcript)=2556nt_BP=46nt
GGCAGCAGCATGGGGAAAGGACGCGCGGGCCGAGTTGGCACCACAGCCTTGCCTCCCCGATTGAAAGAGATGAAAAGCCAGGAATCGGCT
GCAGGTTCCAAACTAGTCCTTCGGTGTGAAACCAGTTCTGAATACTCCTCTCTCAGATTCAAGTGGTTCAAGAATGGGAATGAATTGAAT
CGAAAAAACAAACCACAAAATATCAAGATACAAAAAAAGCCAGGGAAGTCAGAACTTCGCATTAACAAAGCATCACTGGCTGATTCTGGA
GAGTATATGTGCAAAGTGATCAGCAAATTAGGAAATGACAGTGCCTCTGCCAATATCACCATCGTGGAATCAAACGAGATCATCACTGGT
ATGCCAGCCTCAACTGAAGGAGCATATGTGTCTTCAGAGTCTCCCATTAGAATATCAGTATCCACAGAAGGAGCAAATACTTCTTCATCT
ACATCTACATCCACCACTGGGACAAGCCATCTTGTAAAATGTGCGGAGAAGGAGAAAACTTTCTGTGTGAATGGAGGGGAGTGCTTCATG
GTGAAAGACCTTTCAAACCCCTCGAGATACTTGTGCAAGTGCCAACCTGGATTCACTGGAGCAAGATGTACTGAGAATGTGCCCATGAAA
GTCCAAAACCAAGAAAGTGCCCAAATGAGTTTACTGGTGATCGCTGCCAAAACTACGTAATGGCCAGCTTCTACAAGGCGGAGGAGCTGT
ACCAGAAGAGAGTGCTGACCATAACCGGCATCTGCATCGCCCTCCTTGTGGTCGGCATCATGTGTGTGGTGGCCTACTGCAAAACCAAGA
AACAGCGGAAAAAGCTGCATGACCGTCTTCGGCAGAGCCTTCGGTCTGAACGAAACAATATGATGAACATTGCCAATGGGCCTCACCATC
CTAACCCACCCCCCGAGAATGTCCAGCTGGTGAATCAATACGTATCTAAAAACGTCATCTCCAGTGAGCATATTGTTGAGAGAGAAGCAG
AGACATCCTTTTCCACCAGTCACTATACTTCCACAGCCCATCACTCCACTACTGTCACCCAGACTCCTAGCCACAGCTGGAGCAACGGAC
ACACTGAAAGCATCCTTTCCGAAAGCCACTCTGTAATCGTGATGTCATCCGTAGAAAACAGTAGGCACAGCAGCCCAACTGGGGGCCCAA
GAGGACGTCTTAATGGCACAGGAGGCCCTCGTGAATGTAACAGCTTCCTCAGGCATGCCAGAGAAACCCCTGATTCCTACCGAGACTCTC
CTCATAGTGAAAGGTATGTGTCAGCCATGACCACCCCGGCTCGTATGTCACCTGTAGATTTCCACACGCCAAGCTCCCCCAAATCGCCCC
CTTCGGAAATGTCTCCACCCGTGTCCAGCATGACGGTGTCCATGCCTTCCATGGCGGTCAGCCCCTTCATGGAAGAAGAGAGACCTCTAC
TTCTCGTGACACCACCAAGGCTGCGGGAGAAGAAGTTTGACCATCACCCTCAGCAGTTCAGCTCCTTCCACCACAACCCCGCGCATGACA
GTAACAGCCTCCCTGCTAGCCCCTTGAGGATAGTGGAGGATGAGGAGTATGAAACGACCCAAGAGTACGAGCCAGCCCAAGAGCCTGTTA
AGAAACTCGCCAATAGCCGGCGGGCCAAAAGAACCAAGCCCAATGGCCACATTGCTAACAGATTGGAAGTGGACAGCAACACAAGCTCCC
AGAGCAGTAACTCAGAGAGTGAAACAGAAGATGAAAGAGTAGGTGAAGATACGCCTTTCCTGGGCATACAGAACCCCCTGGCAGCCAGTC
TTGAGGCAACACCTGCCTTCCGCCTGGCTGACAGCAGGACTAACCCAGCAGGCCGCTTCTCGACACAGGAAGAAATCCAGGCCAGGCTGT
CTAGTGTAATTGCTAACCAAGACCCTATTGCTGTATAAAACCTAAATAAACACATAGATTCACCTGTAAAACTTTATTTTATATAATAAA
GTATTCCACCTTAAATTAAACAATTTATTTTATTTTAGCAGTTCTGCAAATAGAAAACAGGAAAAAAACTTTTATAAATTAAATATATGT
ATGTAAAAATGTGTTATGTGCCATATGTAGCAATTTTTTACAGTATTTCAAAACGAGAAAGATATCAATGGTGCCTTTATGTTATGTTAT
GTCGAGAGCAAGTTTTGTACAGTTACAGTGATTGCTTTTCCACAGTATTTCTGCAAAACCTCTCATAGATTCAGTTTTTGCTGGCTTCTT
GTGCATTGCATTATGATGTTGACTGGATGTATGATTTGCAAGACTTGCAACTGTCCCTCTGTTTGCTTGTAGTAGCACCCGATCAGTATG
TCTTGTAATGGCACATCCATCCAGATATGCCTCTCTTGTGTATGAAGTTTTCTTTGCTTTCAGAATATGAAATGAGTTGTGTCTACTCTG
CCAGCCAAAGGTTTGCCTCATTGGGCTCTGAGATAATAGTAGATCCAACAGCATGCTACTATTAAATACAGCAAGAAACTGCATTAAGTA

>60276_60276_4_NRG1-NRG1_NRG1_chr8_31496947_ENST00000519301_NRG1_chr8_32453344_ENST00000341377_length(amino acids)=412AA_BP=
MASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVI
SSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHA
RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQF
SSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPF

--------------------------------------------------------------
>60276_60276_5_NRG1-NRG1_NRG1_chr8_31496947_ENST00000519301_NRG1_chr8_32453344_ENST00000356819_length(transcript)=2512nt_BP=46nt
GGCAGCAGCATGGGGAAAGGACGCGCGGGCCGAGTTGGCACCACAGCCTTGCCTCCCCGATTGAAAGAGATGAAAAGCCAGGAATCGGCT
GCAGGTTCCAAACTAGTCCTTCGGTGTGAAACCAGTTCTGAATACTCCTCTCTCAGATTCAAGTGGTTCAAGAATGGGAATGAATTGAAT
CGAAAAAACAAACCACAAAATATCAAGATACAAAAAAAGCCAGGGAAGTCAGAACTTCGCATTAACAAAGCATCACTGGCTGATTCTGGA
GAGTATATGTGCAAAGTGATCAGCAAATTAGGAAATGACAGTGCCTCTGCCAATATCACCATCGTGGAATCAAACGAGATCATCACTGGT
ATGCCAGCCTCAACTGAAGGAGCATATGTGTCTTCAGAGTCTCCCATTAGAATATCAGTATCCACAGAAGGAGCAAATACTTCTTCATCT
ACATCTACATCCACCACTGGGACAAGCCATCTTGTAAAATGTGCGGAGAAGGAGAAAACTTTCTGTGTGAATGGAGGGGAGTGCTTCATG
GTGAAAGACCTTTCAAACCCCTCGAGATACTTGTGCAAGTGCCCAAATGAGTTTACTGGTGATCGCTGCCAAAACTACGTAATGGCCAGC
TTCTACAAGCATCTTGGGATTGAATTTATGGAGGCGGAGGAGCTGTACCAGAAGAGAGTGCTGACCATAACCGGCATCTGCATCGCCCTC
CTTGTGGTCGGCATCATGTGTGTGGTGGCCTACTGCAAAACCAAGAAACAGCGGAAAAAGCTGCATGACCGTCTTCGGCAGAGCCTTCGG
TCTGAACGAAACAATATGATGAACATTGCCAATGGGCCTCACCATCCTAACCCACCCCCCGAGAATGTCCAGCTGGTGAATCAATACGTA
TCTAAAAACGTCATCTCCAGTGAGCATATTGTTGAGAGAGAAGCAGAGACATCCTTTTCCACCAGTCACTATACTTCCACAGCCCATCAC
TCCACTACTGTCACCCAGACTCCTAGCCACAGCTGGAGCAACGGACACACTGAAAGCATCCTTTCCGAAAGCCACTCTGTAATCGTGATG
TCATCCGTAGAAAACAGTAGGCACAGCAGCCCAACTGGGGGCCCAAGAGGACGTCTTAATGGCACAGGAGGCCCTCGTGAATGTAACAGC
TTCCTCAGGCATGCCAGAGAAACCCCTGATTCCTACCGAGACTCTCCTCATAGTGAAAGGTATGTGTCAGCCATGACCACCCCGGCTCGT
ATGTCACCTGTAGATTTCCACACGCCAAGCTCCCCCAAATCGCCCCCTTCGGAAATGTCTCCACCCGTGTCCAGCATGACGGTGTCCATG
CCTTCCATGGCGGTCAGCCCCTTCATGGAAGAAGAGAGACCTCTACTTCTCGTGACACCACCAAGGCTGCGGGAGAAGAAGTTTGACCAT
CACCCTCAGCAGTTCAGCTCCTTCCACCACAACCCCGCGCATGACAGTAACAGCCTCCCTGCTAGCCCCTTGAGGATAGTGGAGGATGAG
GAGTATGAAACGACCCAAGAGTACGAGCCAGCCCAAGAGCCTGTTAAGAAACTCGCCAATAGCCGGCGGGCCAAAAGAACCAAGCCCAAT
GGCCACATTGCTAACAGATTGGAAGTGGACAGCAACACAAGCTCCCAGAGCAGTAACTCAGAGAGTGAAACAGAAGATGAAAGAGTAGGT
GAAGATACGCCTTTCCTGGGCATACAGAACCCCCTGGCAGCCAGTCTTGAGGCAACACCTGCCTTCCGCCTGGCTGACAGCAGGACTAAC
CCAGCAGGCCGCTTCTCGACACAGGAAGAAATCCAGGCCAGGCTGTCTAGTGTAATTGCTAACCAAGACCCTATTGCTGTATAAAACCTA
AATAAACACATAGATTCACCTGTAAAACTTTATTTTATATAATAAAGTATTCCACCTTAAATTAAACAATTTATTTTATTTTAGCAGTTC
TGCAAATAGAAAACAGGAAAAAAACTTTTATAAATTAAATATATGTATGTAAAAATGTGTTATGTGCCATATGTAGCAATTTTTTACAGT
ATTTCAAAACGAGAAAGATATCAATGGTGCCTTTATGTTATGTTATGTCGAGAGCAAGTTTTGTACAGTTACAGTGATTGCTTTTCCACA
GTATTTCTGCAAAACCTCTCATAGATTCAGTTTTTGCTGGCTTCTTGTGCATTGCATTATGATGTTGACTGGATGTATGATTTGCAAGAC
TTGCAACTGTCCCTCTGTTTGCTTGTAGTAGCACCCGATCAGTATGTCTTGTAATGGCACATCCATCCAGATATGCCTCTCTTGTGTATG
AAGTTTTCTTTGCTTTCAGAATATGAAATGAGTTGTGTCTACTCTGCCAGCCAAAGGTTTGCCTCATTGGGCTCTGAGATAATAGTAGAT

>60276_60276_5_NRG1-NRG1_NRG1_chr8_31496947_ENST00000519301_NRG1_chr8_32453344_ENST00000356819_length(amino acids)=624AA_BP=12
MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM
CKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD
LSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSER
NNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSV
ENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSM
AVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHI

--------------------------------------------------------------
>60276_60276_6_NRG1-NRG1_NRG1_chr8_31496947_ENST00000519301_NRG1_chr8_32453344_ENST00000405005_length(transcript)=1938nt_BP=46nt
GGCAGCAGCATGGGGAAAGGACGCGCGGGCCGAGTTGGCACCACAGCCTTGCCTCCCCGATTGAAAGAGATGAAAAGCCAGGAATCGGCT
GCAGGTTCCAAACTAGTCCTTCGGTGTGAAACCAGTTCTGAATACTCCTCTCTCAGATTCAAGTGGTTCAAGAATGGGAATGAATTGAAT
CGAAAAAACAAACCACAAAATATCAAGATACAAAAAAAGCCAGGGAAGTCAGAACTTCGCATTAACAAAGCATCACTGGCTGATTCTGGA
GAGTATATGTGCAAAGTGATCAGCAAATTAGGAAATGACAGTGCCTCTGCCAATATCACCATCGTGGAATCAAACGAGATCATCACTGGT
ATGCCAGCCTCAACTGAAGGAGCATATGTGTCTTCAGAGTCTCCCATTAGAATATCAGTATCCACAGAAGGAGCAAATACTTCTTCATCT
ACATCTACATCCACCACTGGGACAAGCCATCTTGTAAAATGTGCGGAGAAGGAGAAAACTTTCTGTGTGAATGGAGGGGAGTGCTTCATG
GTGAAAGACCTTTCAAACCCCTCGAGATACTTGTGCAAGTGCCAACCTGGATTCACTGGAGCAAGATGTACTGAGAATGTGCCCATGAAA
GTCCAAAACCAAGAAAAGGCGGAGGAGCTGTACCAGAAGAGAGTGCTGACCATAACCGGCATCTGCATCGCCCTCCTTGTGGTCGGCATC
ATGTGTGTGGTGGCCTACTGCAAAACCAAGAAACAGCGGAAAAAGCTGCATGACCGTCTTCGGCAGAGCCTTCGGTCTGAACGAAACAAT
ATGATGAACATTGCCAATGGGCCTCACCATCCTAACCCACCCCCCGAGAATGTCCAGCTGGTGAATCAATACGTATCTAAAAACGTCATC
TCCAGTGAGCATATTGTTGAGAGAGAAGCAGAGACATCCTTTTCCACCAGTCACTATACTTCCACAGCCCATCACTCCACTACTGTCACC
CAGACTCCTAGCCACAGCTGGAGCAACGGACACACTGAAAGCATCCTTTCCGAAAGCCACTCTGTAATCGTGATGTCATCCGTAGAAAAC
AGTAGGCACAGCAGCCCAACTGGGGGCCCAAGAGGACGTCTTAATGGCACAGGAGGCCCTCGTGAATGTAACAGCTTCCTCAGGCATGCC
AGAGAAACCCCTGATTCCTACCGAGACTCTCCTCATAGTGAAAGGTATGTGTCAGCCATGACCACCCCGGCTCGTATGTCACCTGTAGAT
TTCCACACGCCAAGCTCCCCCAAATCGCCCCCTTCGGAAATGTCTCCACCCGTGTCCAGCATGACGGTGTCCATGCCTTCCATGGCGGTC
AGCCCCTTCATGGAAGAAGAGAGACCTCTACTTCTCGTGACACCACCAAGGCTGCGGGAGAAGAAGTTTGACCATCACCCTCAGCAGTTC
AGCTCCTTCCACCACAACCCCGCGCATGACAGTAACAGCCTCCCTGCTAGCCCCTTGAGGATAGTGGAGGATGAGGAGTATGAAACGACC
CAAGAGTACGAGCCAGCCCAAGAGCCTGTTAAGAAACTCGCCAATAGCCGGCGGGCCAAAAGAACCAAGCCCAATGGCCACATTGCTAAC
AGATTGGAAGTGGACAGCAACACAAGCTCCCAGAGCAGTAACTCAGAGAGTGAAACAGAAGATGAAAGAGTAGGTGAAGATACGCCTTTC
CTGGGCATACAGAACCCCCTGGCAGCCAGTCTTGAGGCAACACCTGCCTTCCGCCTGGCTGACAGCAGGACTAACCCAGCAGGCCGCTTC
TCGACACAGGAAGAAATCCAGGCCAGGCTGTCTAGTGTAATTGCTAACCAAGACCCTATTGCTGTATAAAACCTAAATAAACACATAGAT

>60276_60276_6_NRG1-NRG1_NRG1_chr8_31496947_ENST00000519301_NRG1_chr8_32453344_ENST00000405005_length(amino acids)=619AA_BP=12
MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM
CKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD
LSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMN
IANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRH
SSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPF
MEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLE

--------------------------------------------------------------
>60276_60276_7_NRG1-NRG1_NRG1_chr8_31496947_ENST00000519301_NRG1_chr8_32453344_ENST00000519301_length(transcript)=1785nt_BP=46nt
GGCAGCAGCATGGGGAAAGGACGCGCGGGCCGAGTTGGCACCACAGCCTTGCCTCCCCGATTGAAAGAGATGAAAAGCCAGGAATCGGCT
GCAGGTTCCAAACTAGTCCTTCGGTGTGAAACCAGTTCTGAATACTCCTCTCTCAGATTCAAGTGGTTCAAGAATGGGAATGAATTGAAT
CGAAAAAACAAACCACAAAATATCAAGATACAAAAAAAGCCAGGGAAGTCAGAACTTCGCATTAACAAAGCATCACTGGCTGATTCTGGA
GAGTATATGTGCAAAGTGATCAGCAAATTAGGAAATGACAGTGCCTCTGCCAATATCACCATCGTGGAATCAAACGCTACATCTACATCC
ACCACTGGGACAAGCCATCTTGTAAAATGTGCGGAGAAGGAGAAAACTTTCTGTGTGAATGGAGGGGAGTGCTTCATGGTGAAAGACCTT
TCAAACCCCTCGAGATACTTGTGCAAGTGCCCAAATGAGTTTACTGGTGATCGCTGCCAAAACTACGTAATGGCCAGCTTCTACAAGCAT
CTTGGGATTGAATTTATGGAGGCGGAGGAGCTGTACCAGAAGAGAGTGCTGACCATAACCGGCATCTGCATCGCCCTCCTTGTGGTCGGC
ATCATGTGTGTGGTGGCCTACTGCAAAACCAAGAAACAGCGGAAAAAGCTGCATGACCGTCTTCGGCAGAGCCTTCGGTCTGAACGAAAC
AATATGATGAACATTGCCAATGGGCCTCACCATCCTAACCCACCCCCCGAGAATGTCCAGCTGGTGAATCAATACGTATCTAAAAACGTC
ATCTCCAGTGAGCATATTGTTGAGAGAGAAGCAGAGACATCCTTTTCCACCAGTCACTATACTTCCACAGCCCATCACTCCACTACTGTC
ACCCAGACTCCTAGCCACAGCTGGAGCAACGGACACACTGAAAGCATCCTTTCCGAAAGCCACTCTGTAATCGTGATGTCATCCGTAGAA
AACAGTAGGCACAGCAGCCCAACTGGGGGCCCAAGAGGACGTCTTAATGGCACAGGAGGCCCTCGTGAATGTAACAGCTTCCTCAGGCAT
GCCAGAGAAACCCCTGATTCCTACCGAGACTCTCCTCATAGTGAAAGGTATGTGTCAGCCATGACCACCCCGGCTCGTATGTCACCTGTA
GATTTCCACACGCCAAGCTCCCCCAAATCGCCCCCTTCGGAAATGTCTCCACCCGTGTCCAGCATGACGGTGTCCATGCCTTCCATGGCG
GTCAGCCCCTTCATGGAAGAAGAGAGACCTCTACTTCTCGTGACACCACCAAGGCTGCGGGAGAAGAAGTTTGACCATCACCCTCAGCAG
TTCAGCTCCTTCCACCACAACCCCGCGCATGACAGTAACAGCCTCCCTGCTAGCCCCTTGAGGATAGTGGAGGATGAGGAGTATGAAACG
ACCCAAGAGTACGAGCCAGCCCAAGAGCCTGTTAAGAAACTCGCCAATAGCCGGCGGGCCAAAAGAACCAAGCCCAATGGCCACATTGCT
AACAGATTGGAAGTGGACAGCAACACAAGCTCCCAGAGCAGTAACTCAGAGAGTGAAACAGAAGATGAAAGAGTAGGTGAAGATACGCCT
TTCCTGGGCATACAGAACCCCCTGGCAGCCAGTCTTGAGGCAACACCTGCCTTCCGCCTGGCTGACAGCAGGACTAACCCAGCAGGCCGC

>60276_60276_7_NRG1-NRG1_NRG1_chr8_31496947_ENST00000519301_NRG1_chr8_32453344_ENST00000519301_length(amino acids)=590AA_BP=12
MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM
CKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGI
EFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISS
EHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARE
TPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSS
FHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLG

--------------------------------------------------------------
>60276_60276_8_NRG1-NRG1_NRG1_chr8_31496947_ENST00000519301_NRG1_chr8_32453344_ENST00000520407_length(transcript)=1026nt_BP=46nt
GGCAGCAGCATGGGGAAAGGACGCGCGGGCCGAGTTGGCACCACAGCCTTGCCTCCCCGATTGAAAGAGATGAAAAGCCAGGAATCGGCT
GCAGGTTCCAAACTAGTCCTTCGGTGTGAAACCAGTTCTGAATACTCCTCTCTCAGATTCAAGTGGTTCAAGAATGGGAATGAATTGAAT
CGAAAAAACAAACCACAAAATATCAAGATACAAAAAAAGCCAGGGAAGTCAGAACTTCGCATTAACAAAGCATCACTGGCTGATTCTGGA
GAGTATATGTGCAAAGTGATCAGCAAATTAGGAAATGACAGTGCCTCTGCCAATATCACCATCGTGGAATCAAACGCTACATCTACATCC
ACCACTGGGACAAGCCATCTTGTAAAATGTGCGGAGAAGGAGAAAACTTTCTGTGTGAATGGAGGGGAGTGCTTCATGGTGAAAGACCTT
TCAAACCCCTCGAGATACTTGTGCAAGTGCCCAAATGAGTTTACTGGTGATCGCTGCCAAAACTACGTAATGGCCAGCTTCTACAGTACG
TCCACTCCCTTTCTGTCTCTGCCTGAATAGGAGCATGCTCAGTTGGTGCTGCTTTCTTGTTGCTGCATCTCCCCTCAGATTCCACCTAGA
GCTAGATGTGTCTTACCAGATCTAATATTGACTGCCTCTGCCTGTCGCATGAGAACATTAACAAAAGCAATTGTATTACTTCCTCTGTTC
GCGACTAGTTGGCTCTGAGATACTAATAGGTGTGTGAGGCTCCGGATGTTTCTGGAATTGATATTGAATGATGTGATACAAATTGATAGT
CAATATCAAGCAGTGAAATATGATAATAAAGGCATTTCAAAGTCTCACTTTTATTGATAAAATAAAAATCATTCTACTGAACAGTCCATC
TTCTTTATACAATGACCACATCCTGAAAAGGGTGTTGCTAAGCTGTAACCGATATGCACTTGAAATGATGGTAAGTTAATTTTGATTCAG

>60276_60276_8_NRG1-NRG1_NRG1_chr8_31496947_ENST00000519301_NRG1_chr8_32453344_ENST00000520407_length(amino acids)=186AA_BP=12
MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM
CKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTP

--------------------------------------------------------------
>60276_60276_9_NRG1-NRG1_NRG1_chr8_31496947_ENST00000519301_NRG1_chr8_32453344_ENST00000521670_length(transcript)=1607nt_BP=46nt
GGCAGCAGCATGGGGAAAGGACGCGCGGGCCGAGTTGGCACCACAGCCTTGCCTCCCCGATTGAAAGAGATGAAAAGCCAGGAATCGGCT
GCAGGTTCCAAACTAGTCCTTCGGTGTGAAACCAGTTCTGAATACTCCTCTCTCAGATTCAAGTGGTTCAAGAATGGGAATGAATTGAAT
CGAAAAAACAAACCACAAAATATCAAGATACAAAAAAAGCCAGGGAAGTCAGAACTTCGCATTAACAAAGCATCACTGGCTGATTCTGGA
GAGTATATGTGCAAAGTGATCAGCAAATTAGGAAATGACAGTGCCTCTGCCAATATCACCATCGTGGAATCAAACGAGATCATCACTGGT
ATGCCAGCCTCAACTGAAGGAGCATATGTGTCTTCAGAGTCTCCCATTAGAATATCAGTATCCACAGAAGGAGCAAATACTTCTTCATCT
ACATCTACATCCACCACTGGGACAAGCCATCTTGTAAAATGTGCGGAGAAGGAGAAAACTTTCTGTGTGAATGGAGGGGAGTGCTTCATG
GTGAAAGACCTTTCAAACCCCTCGAGATACTTGTGCAAGTGCCAACCTGGATTCACTGGAGCAAGATGTACTGAGAATGTGCCCATGAAA
GTCCAAAACCAAGAAAAGGCGGAGGAGCTGTACCAGAAGAGAGTGCTGACCATAACCGGCATCTGCATCGCCCTCCTTGTGGTCGGCATC
ATGTGTGTGGTGGCCTACTGCAAAACCAAGAAACAGCGGAAAAAGCTGCATGACCGTCTTCGGCAGAGCCTTCGGTCTGAACGAAACAAT
ATGATGAACATTGCCAATGGGCCTCACCATCCTAACCCACCCCCCGAGAATGTCCAGCTGGTGAATCAATACGTATCTAAAAACGTCATC
TCCAGTGAGCATATTGTTGAGAGAGAAGCAGAGACATCCTTTTCCACCAGTCACTATACTTCCACAGCCCATCACTCCACTACTGTCACC
CAGACTCCTAGCCACAGCTGGAGCAACGGACACACTGAAAGCATCCTTTCCGAAAGCCACTCTGTAATCGTGATGTCATCCGTAGAAAAC
AGTAGGCACAGCAGCCCAACTGGGGGCCCAAGAGGACGTCTTAATGGCACAGGAGGCCCTCGTGAATGTAACAGCTTCCTCAGGCATGCC
AGAGAAACCCCTGATTCCTACCGAGACTCTCCTCATAGTGAAAGACATAACCTTATAGCTGAGCTAAGGAGAAACAAGGCACACAGATCC
AAATGCATGCAGATCCAGCTATCAGCAACTCATCTTAGATCTTCTTCCATTCCCCATTTGGGCTTCATTCTCTAAGACCCCTTGGCCTTT
AGGAAGGTATGTGTCAGCCATGACCACCCCGGCTCGTATGTCACCTGTAGATTTCCACACGCCAAGCTCCCCCAAATCGCCCCCTTCGGA
AATGTCTCCACCCGTGTCCAGCATGACGGTGTCCATGCCTTCCATGGCGGTCAGCCCCTTCATGGAAGAAGAGAGACCTCTACTTCTCGT

>60276_60276_9_NRG1-NRG1_NRG1_chr8_31496947_ENST00000519301_NRG1_chr8_32453344_ENST00000521670_length(amino acids)=441AA_BP=12
MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM
CKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD
LSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMN
IANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRH

--------------------------------------------------------------
>60276_60276_10_NRG1-NRG1_NRG1_chr8_31496947_ENST00000519301_NRG1_chr8_32453344_ENST00000523079_length(transcript)=1788nt_BP=46nt
GGCAGCAGCATGGGGAAAGGACGCGCGGGCCGAGTTGGCACCACAGCCTTGCCTCCCCGATTGAAAGAGATGAAAAGCCAGGAATCGGCT
GCAGGTTCCAAACTAGTCCTTCGGTGTGAAACCAGTTCTGAATACTCCTCTCTCAGATTCAAGTGGTTCAAGAATGGGAATGAATTGAAT
CGAAAAAACAAACCACAAAATATCAAGATACAAAAAAAGCCAGGGAAGTCAGAACTTCGCATTAACAAAGCATCACTGGCTGATTCTGGA
GAGTATATGTGCAAAGTGATCAGCAAATTAGGAAATGACAGTGCCTCTGCCAATATCACCATCGTGGAATCAAACGAGATCATCACTGGT
ATGCCAGCCTCAACTGAAGGAGCATATGTGTCTTCAGAGTCTCCCATTAGAATATCAGTATCCACAGAAGGAGCAAATACTTCTTCATCT
ACATCTACATCCACCACTGGGACAAGCCATCTTGTAAAATGTGCGGAGAAGGAGAAAACTTTCTGTGTGAATGGAGGGGAGTGCTTCATG
GTGAAAGACCTTTCAAACCCCTCGAGATACTTGTGCAAGTGCCCAAATGAGTTTACTGGTGATCGCTGCCAAAACTACGTAATGGCCAGC
TTCTACAAGGCGGAGGAGCTGTACCAGAAGAGAGTGCTGACCATAACCGGCATCTGCATCGCCCTCCTTGTGGTCGGCATCATGTGTGTG
GTGGCCTACTGCAAAACCAAGAAACAGCGGAAAAAGCTGCATGACCGTCTTCGGCAGAGCCTTCGGTCTGAACGAAACAATATGATGAAC
ATTGCCAATGGGCCTCACCATCCTAACCCACCCCCCGAGAATGTCCAGCTGGTGAATCAATACGTATCTAAAAACGTCATCTCCAGTGAG
CATATTGTTGAGAGAGAAGCAGAGACATCCTTTTCCACCAGTCACTATACTTCCACAGCCCATCACTCCACTACTGTCACCCAGACTCCT
AGCCACAGCTGGAGCAACGGACACACTGAAAGCATCCTTTCCGAAAGCCACTCTGTAATCGTGATGTCATCCGTAGAAAACAGTAGGCAC
AGCAGCCCAACTGGGGGCCCAAGAGGACGTCTTAATGGCACAGGAGGCCCTCGTGAATGTAACAGCTTCCTCAGGCATGCCAGAGAAACC
CCTGATTCCTACCGAGACTCTCCTCATAGTGAAAGGTAAAACCGAAGGGCAAAGCTACTGCAGAGGAGAAACTCAGTCAGAGAATCCCTG
TGAGCACCTGCGGTCTCACCTCAGGAAATCTACTCTAATCAGAATAAGGGGCGGCAGTTACCTGTTCTAGGAGTGCTCCTAGTTGATGAA
GTCATCTCTTTGTTTGACGGAACTTATTTCTTCTGAGCTTCTCTCGTCGTCCCAGTGACTGACAGGCAACAGACTCTTAAAGAGCTGGGA
TGCTTTGATGCGGAAGGTGCAGCACATGGAGTTTCCAGCTCTGGCCATGGGCTCAGACCCACTCGGGGTCTCAGTGTCCTCAGTTGTAAC
ATTAGAGAGATGGCATCAATGCTTGATAAGGACCCTTCTATAATTCCAATTGCCAGTTATCCAAACTCTGATTCGGTGGTCGAGCTGGCC
TCGTGTTCTTATCTGCTAACCCTGTCTTACCTTCCAGCCTCAGTTAAGTCAAATCAAGGGCTATGTCATTGCTGAATGTCATGGGGGGCA

>60276_60276_10_NRG1-NRG1_NRG1_chr8_31496947_ENST00000519301_NRG1_chr8_32453344_ENST00000523079_length(amino acids)=399AA_BP=12
MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM
CKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD
LSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIAN
GPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSP

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Fusion Gene PPI Analysis for NRG1-NRG1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for NRG1-NRG1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for NRG1-NRG1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source