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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NRG1-PMEPA1 (FusionGDB2 ID:60277)

Fusion Gene Summary for NRG1-PMEPA1

check button Fusion gene summary
Fusion gene informationFusion gene name: NRG1-PMEPA1
Fusion gene ID: 60277
HgeneTgene
Gene symbol

NRG1

PMEPA1

Gene ID

3084

56937

Gene nameneuregulin 1prostate transmembrane protein, androgen induced 1
SynonymsARIA|GGF|GGF2|HGL|HRG|HRG1|HRGA|MST131|MSTP131|NDF|NRG1-IT2|SMDFSTAG1|TMEPAI
Cytomap

8p12

20q13.31

Type of geneprotein-codingprotein-coding
Descriptionpro-neuregulin-1, membrane-bound isoformacetylcholine receptor-inducing activityglial growth factor 2heregulin, alpha (45kD, ERBB2 p185-activator)neu differentiation factorpro-NRG1sensory and motor neuron derived factorprotein TMEPAIsolid tumor-associated 1 proteintransmembrane, prostate androgen induced RNA
Modification date2020032020200313
UniProtAcc

Q02297

.
Ensembl transtripts involved in fusion geneENST00000520407, ENST00000287842, 
ENST00000287845, ENST00000338921, 
ENST00000341377, ENST00000356819, 
ENST00000405005, ENST00000519301, 
ENST00000520502, ENST00000521670, 
ENST00000523079, ENST00000523681, 
ENST00000539990, 		ENST00000265626, 
ENST00000347215, ENST00000395814, 
ENST00000395816, ENST00000472841, 
ENST00000341744, 
Fusion gene scores* DoF score12 X 10 X 7=8408 X 5 X 5=200
# samples 128
** MAII scorelog2(12/840*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/200*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NRG1 [Title/Abstract] AND PMEPA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNRG1(31498245)-PMEPA1(56234753), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNRG1

GO:0003222

ventricular trabecula myocardium morphogenesis

17336907

HgeneNRG1

GO:0031334

positive regulation of protein complex assembly

10559227

HgeneNRG1

GO:0038127

ERBB signaling pathway

11389077

HgeneNRG1

GO:0038129

ERBB3 signaling pathway

27353365

HgeneNRG1

GO:0045892

negative regulation of transcription, DNA-templated

15073182

HgeneNRG1

GO:0051048

negative regulation of secretion

10559227

HgeneNRG1

GO:0060379

cardiac muscle cell myoblast differentiation

17336907

HgeneNRG1

GO:0060956

endocardial cell differentiation

17336907

TgenePMEPA1

GO:0010991

negative regulation of SMAD protein complex assembly

20129061

TgenePMEPA1

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

24627487

TgenePMEPA1

GO:0060394

negative regulation of pathway-restricted SMAD protein phosphorylation

24627487


check buttonFusion gene breakpoints across NRG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PMEPA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-ND-A4WA-01ANRG1chr8

31498245

-PMEPA1chr20

56234753

-
ChimerDB4UCSTCGA-ND-A4WA-01ANRG1chr8

31498245

+PMEPA1chr20

56234753

-
ChimerDB4UCSTCGA-ND-A4WANRG1chr8

31498245

+PMEPA1chr20

56234753

-


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Fusion Gene ORF analysis for NRG1-PMEPA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000520407ENST00000265626NRG1chr8

31498245

+PMEPA1chr20

56234753

-
5CDS-5UTRENST00000520407ENST00000347215NRG1chr8

31498245

+PMEPA1chr20

56234753

-
5CDS-5UTRENST00000520407ENST00000395814NRG1chr8

31498245

+PMEPA1chr20

56234753

-
5CDS-5UTRENST00000520407ENST00000395816NRG1chr8

31498245

+PMEPA1chr20

56234753

-
5CDS-5UTRENST00000520407ENST00000472841NRG1chr8

31498245

+PMEPA1chr20

56234753

-
In-frameENST00000520407ENST00000341744NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-3CDSENST00000287842ENST00000341744NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-3CDSENST00000287845ENST00000341744NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-3CDSENST00000338921ENST00000341744NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-3CDSENST00000341377ENST00000341744NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-3CDSENST00000356819ENST00000341744NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-3CDSENST00000405005ENST00000341744NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-3CDSENST00000519301ENST00000341744NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-3CDSENST00000520502ENST00000341744NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-3CDSENST00000521670ENST00000341744NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-3CDSENST00000523079ENST00000341744NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-3CDSENST00000523681ENST00000341744NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-3CDSENST00000539990ENST00000341744NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000287842ENST00000265626NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000287842ENST00000347215NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000287842ENST00000395814NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000287842ENST00000395816NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000287842ENST00000472841NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000287845ENST00000265626NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000287845ENST00000347215NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000287845ENST00000395814NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000287845ENST00000395816NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000287845ENST00000472841NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000338921ENST00000265626NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000338921ENST00000347215NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000338921ENST00000395814NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000338921ENST00000395816NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000338921ENST00000472841NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000341377ENST00000265626NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000341377ENST00000347215NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000341377ENST00000395814NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000341377ENST00000395816NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000341377ENST00000472841NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000356819ENST00000265626NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000356819ENST00000347215NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000356819ENST00000395814NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000356819ENST00000395816NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000356819ENST00000472841NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000405005ENST00000265626NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000405005ENST00000347215NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000405005ENST00000395814NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000405005ENST00000395816NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000405005ENST00000472841NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000519301ENST00000265626NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000519301ENST00000347215NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000519301ENST00000395814NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000519301ENST00000395816NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000519301ENST00000472841NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000520502ENST00000265626NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000520502ENST00000347215NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000520502ENST00000395814NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000520502ENST00000395816NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000520502ENST00000472841NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000521670ENST00000265626NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000521670ENST00000347215NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000521670ENST00000395814NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000521670ENST00000395816NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000521670ENST00000472841NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000523079ENST00000265626NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000523079ENST00000347215NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000523079ENST00000395814NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000523079ENST00000395816NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000523079ENST00000472841NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000523681ENST00000265626NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000523681ENST00000347215NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000523681ENST00000395814NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000523681ENST00000395816NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000523681ENST00000472841NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000539990ENST00000265626NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000539990ENST00000347215NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000539990ENST00000395814NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000539990ENST00000395816NRG1chr8

31498245

+PMEPA1chr20

56234753

-
intron-5UTRENST00000539990ENST00000472841NRG1chr8

31498245

+PMEPA1chr20

56234753

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000520407NRG1chr831498245+ENST00000341744PMEPA1chr2056234753-53919752301729499

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000520407ENST00000341744NRG1chr831498245+PMEPA1chr2056234753-0.0323828980.96761703

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Fusion Genomic Features for NRG1-PMEPA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NRG1-PMEPA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:31498245/chr20:56234753)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NRG1

Q02297

.
FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity). {ECO:0000250|UniProtKB:P43322, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:1348215, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:7902537}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNRG1chr8:31498245chr20:56234753ENST00000520407+15165_177248423.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:31498245chr20:56234753ENST00000520407+15178_222248423.0DomainEGF-like
HgeneNRG1chr8:31498245chr20:56234753ENST00000520407+1537_128248423.0DomainNote=Ig-like C2-type
HgeneNRG1chr8:31498245chr20:56234753ENST00000520407+1520_242248423.0Topological domainExtracellular
TgenePMEPA1chr8:31498245chr20:56234753ENST0000026562604158_1610238.0MotifNote=PPxY motif 1
TgenePMEPA1chr8:31498245chr20:56234753ENST0000026562604229_2320238.0MotifNote=PPxY motif 2
TgenePMEPA1chr8:31498245chr20:56234753ENST0000034174404158_16136288.0MotifNote=PPxY motif 1
TgenePMEPA1chr8:31498245chr20:56234753ENST0000034174404229_23236288.0MotifNote=PPxY motif 2
TgenePMEPA1chr8:31498245chr20:56234753ENST0000034721504158_1611253.0MotifNote=PPxY motif 1
TgenePMEPA1chr8:31498245chr20:56234753ENST0000034721504229_2321253.0MotifNote=PPxY motif 2
TgenePMEPA1chr8:31498245chr20:56234753ENST0000039581404158_1610238.0MotifNote=PPxY motif 1
TgenePMEPA1chr8:31498245chr20:56234753ENST0000039581404229_2320238.0MotifNote=PPxY motif 2
TgenePMEPA1chr8:31498245chr20:56234753ENST0000039581604158_1610238.0MotifNote=PPxY motif 1
TgenePMEPA1chr8:31498245chr20:56234753ENST0000039581604229_2320238.0MotifNote=PPxY motif 2
TgenePMEPA1chr8:31498245chr20:56234753ENST00000265626041_400238.0Topological domainLumenal
TgenePMEPA1chr8:31498245chr20:56234753ENST000002656260464_2870238.0Topological domainCytoplasmic
TgenePMEPA1chr8:31498245chr20:56234753ENST000003417440464_28736288.0Topological domainCytoplasmic
TgenePMEPA1chr8:31498245chr20:56234753ENST00000347215041_401253.0Topological domainLumenal
TgenePMEPA1chr8:31498245chr20:56234753ENST000003472150464_2871253.0Topological domainCytoplasmic
TgenePMEPA1chr8:31498245chr20:56234753ENST00000395814041_400238.0Topological domainLumenal
TgenePMEPA1chr8:31498245chr20:56234753ENST000003958140464_2870238.0Topological domainCytoplasmic
TgenePMEPA1chr8:31498245chr20:56234753ENST00000395816041_400238.0Topological domainLumenal
TgenePMEPA1chr8:31498245chr20:56234753ENST000003958160464_2870238.0Topological domainCytoplasmic
TgenePMEPA1chr8:31498245chr20:56234753ENST000002656260441_630238.0TransmembraneHelical
TgenePMEPA1chr8:31498245chr20:56234753ENST000003417440441_6336288.0TransmembraneHelical
TgenePMEPA1chr8:31498245chr20:56234753ENST000003472150441_631253.0TransmembraneHelical
TgenePMEPA1chr8:31498245chr20:56234753ENST000003958140441_630238.0TransmembraneHelical
TgenePMEPA1chr8:31498245chr20:56234753ENST000003958160441_630238.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNRG1chr8:31498245chr20:56234753ENST00000287842+112165_1770638.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:31498245chr20:56234753ENST00000341377+113165_1770525.3333333333334Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:31498245chr20:56234753ENST00000356819+113165_1770646.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:31498245chr20:56234753ENST00000405005+112165_1770641.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:31498245chr20:56234753ENST00000519301+111165_1770591.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:31498245chr20:56234753ENST00000520502+13165_1770297.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:31498245chr20:56234753ENST00000521670+113165_1770477.3333333333333Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:31498245chr20:56234753ENST00000523079+111165_1770421.0Compositional biasNote=Ser/Thr-rich
HgeneNRG1chr8:31498245chr20:56234753ENST00000287842+112178_2220638.0DomainEGF-like
HgeneNRG1chr8:31498245chr20:56234753ENST00000287842+11237_1280638.0DomainNote=Ig-like C2-type
HgeneNRG1chr8:31498245chr20:56234753ENST00000341377+113178_2220525.3333333333334DomainEGF-like
HgeneNRG1chr8:31498245chr20:56234753ENST00000341377+11337_1280525.3333333333334DomainNote=Ig-like C2-type
HgeneNRG1chr8:31498245chr20:56234753ENST00000356819+113178_2220646.0DomainEGF-like
HgeneNRG1chr8:31498245chr20:56234753ENST00000356819+11337_1280646.0DomainNote=Ig-like C2-type
HgeneNRG1chr8:31498245chr20:56234753ENST00000405005+112178_2220641.0DomainEGF-like
HgeneNRG1chr8:31498245chr20:56234753ENST00000405005+11237_1280641.0DomainNote=Ig-like C2-type
HgeneNRG1chr8:31498245chr20:56234753ENST00000519301+111178_2220591.0DomainEGF-like
HgeneNRG1chr8:31498245chr20:56234753ENST00000519301+11137_1280591.0DomainNote=Ig-like C2-type
HgeneNRG1chr8:31498245chr20:56234753ENST00000520502+13178_2220297.0DomainEGF-like
HgeneNRG1chr8:31498245chr20:56234753ENST00000520502+1337_1280297.0DomainNote=Ig-like C2-type
HgeneNRG1chr8:31498245chr20:56234753ENST00000521670+113178_2220477.3333333333333DomainEGF-like
HgeneNRG1chr8:31498245chr20:56234753ENST00000521670+11337_1280477.3333333333333DomainNote=Ig-like C2-type
HgeneNRG1chr8:31498245chr20:56234753ENST00000523079+111178_2220421.0DomainEGF-like
HgeneNRG1chr8:31498245chr20:56234753ENST00000523079+11137_1280421.0DomainNote=Ig-like C2-type
HgeneNRG1chr8:31498245chr20:56234753ENST00000287842+11220_2420638.0Topological domainExtracellular
HgeneNRG1chr8:31498245chr20:56234753ENST00000287842+112266_6400638.0Topological domainCytoplasmic
HgeneNRG1chr8:31498245chr20:56234753ENST00000341377+11320_2420525.3333333333334Topological domainExtracellular
HgeneNRG1chr8:31498245chr20:56234753ENST00000341377+113266_6400525.3333333333334Topological domainCytoplasmic
HgeneNRG1chr8:31498245chr20:56234753ENST00000356819+11320_2420646.0Topological domainExtracellular
HgeneNRG1chr8:31498245chr20:56234753ENST00000356819+113266_6400646.0Topological domainCytoplasmic
HgeneNRG1chr8:31498245chr20:56234753ENST00000405005+11220_2420641.0Topological domainExtracellular
HgeneNRG1chr8:31498245chr20:56234753ENST00000405005+112266_6400641.0Topological domainCytoplasmic
HgeneNRG1chr8:31498245chr20:56234753ENST00000519301+11120_2420591.0Topological domainExtracellular
HgeneNRG1chr8:31498245chr20:56234753ENST00000519301+111266_6400591.0Topological domainCytoplasmic
HgeneNRG1chr8:31498245chr20:56234753ENST00000520407+15266_640248423.0Topological domainCytoplasmic
HgeneNRG1chr8:31498245chr20:56234753ENST00000520502+1320_2420297.0Topological domainExtracellular
HgeneNRG1chr8:31498245chr20:56234753ENST00000520502+13266_6400297.0Topological domainCytoplasmic
HgeneNRG1chr8:31498245chr20:56234753ENST00000521670+11320_2420477.3333333333333Topological domainExtracellular
HgeneNRG1chr8:31498245chr20:56234753ENST00000521670+113266_6400477.3333333333333Topological domainCytoplasmic
HgeneNRG1chr8:31498245chr20:56234753ENST00000523079+11120_2420421.0Topological domainExtracellular
HgeneNRG1chr8:31498245chr20:56234753ENST00000523079+111266_6400421.0Topological domainCytoplasmic
HgeneNRG1chr8:31498245chr20:56234753ENST00000287842+112243_2650638.0TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:31498245chr20:56234753ENST00000341377+113243_2650525.3333333333334TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:31498245chr20:56234753ENST00000356819+113243_2650646.0TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:31498245chr20:56234753ENST00000405005+112243_2650641.0TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:31498245chr20:56234753ENST00000519301+111243_2650591.0TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:31498245chr20:56234753ENST00000520407+15243_265248423.0TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:31498245chr20:56234753ENST00000520502+13243_2650297.0TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:31498245chr20:56234753ENST00000521670+113243_2650477.3333333333333TransmembraneHelical%3B Note%3DInternal signal sequence
HgeneNRG1chr8:31498245chr20:56234753ENST00000523079+111243_2650421.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgenePMEPA1chr8:31498245chr20:56234753ENST00000341744041_4036288.0Topological domainLumenal


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Fusion Gene Sequence for NRG1-PMEPA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>60277_60277_1_NRG1-PMEPA1_NRG1_chr8_31498245_ENST00000520407_PMEPA1_chr20_56234753_ENST00000341744_length(transcript)=5391nt_BP=975nt
TTTTTTTTGCCCTTATACCTCTTCGCCTTTCTGTGGTTCCATCCACTTCTTCCCCCTCCTCCTCCCATAAACAACTCTCCTACCCCTGCA
CCCCCAATAAATAAATAAAAGGAGGAGGGCAAGGGGGGAGGAGGAGGAGTGGTGCTGCGAGGGGAAGGAAAAGGGAGGCAGCGCGAGAGA
GCCGGGCAGAGTCCGAACCGACAGCCAGAAGCCCGCACGCACCTCGCACCATGAGATGGCGACGCGCCCCGCGCCGCTCCGGGCGTCCCG
GCCCCCGGGCCCAGCGCCCCGGCTCCGCCGCCCGCTCGTCGCCGCCGCTGCCGCTGCTGCCACTACTGCTGCTGCTGGGGACCGCGGCCC
TGGCGCCGGGGGCGGCGGCCGGCAACGAGGCGGCTCCCGCGGGGGCCTCGGTGTGCTACTCGTCCCCGCCCAGCGTGGGATCGGTGCAGG
AGCTAGCTCAGCGCGCCGCGGTGGTGATCGAGGGAAAGGTGCACCCGCAGCGGCGGCAGCAGGGGGCACTCGACAGGAAGGCGGCGGCGG
CGGCGGGCGAGGCAGGGGCGTGGGGCGGCGATCGCGAGCCGCCAGCCGCGGGCCCACGGGCGCTGGGGCCGCCCGCCGAGGAGCCGCTGC
TCGCCGCCAACGGGACCGTGCCCTCTTGGCCCACCGCCCCGGTGCCCAGCGCCGGCGAGCCCGGGGAGGAGGCGCCCTATCTGGTGAAGG
TGCACCAGGTGTGGGCGGTGAAAGCCGGGGGCTTGAAGAAGGACTCGCTGCTCACCGTGCGCCTGGGGACCTGGGGCCACCCCGCCTTCC
CCTCCTGCGGGAGGCTCAAGGAGGACAGCAGGTACATCTTCTTCATGGAGCCCGACGCCAACAGCACCAGCCGCGCGCCGGCCGCCTTCC
GAGCCTCTTTCCCCCCTCTGGAGACGGGCCGGAACCTCAAGAAGGAGGTCAGCCGGGTGCTGTGCAAGCGGTGCGCGGAGCTGGAGTTTG
TTCAGATCATCATCATCGTGGTGGTGATGATGGTGATGGTGGTGGTGATCACGTGCCTGCTGAGCCACTACAAGCTGTCTGCACGGTCCT
TCATCAGCCGGCACAGCCAGGGGCGGAGGAGAGAAGATGCCCTGTCCTCAGAAGGATGCCTGTGGCCCTCGGAGAGCACAGTGTCAGGCA
ACGGAATCCCAGAGCCGCAGGTCTACGCCCCGCCTCGGCCCACCGACCGCCTGGCCGTGCCGCCCTTCGCCCAGCGGGAGCGCTTCCACC
GCTTCCAGCCCACCTATCCGTACCTGCAGCACGAGATCGACCTGCCACCCACCATCTCGCTGTCAGACGGGGAGGAGCCCCCACCCTACC
AGGGCCCCTGCACCCTCCAGCTTCGGGACCCCGAGCAGCAGCTGGAACTGAACCGGGAGTCGGTGCGCGCACCCCCAAACAGAACCATCT
TCGACAGTGACCTGATGGATAGTGCCAGGCTGGGCGGCCCCTGCCCCCCCAGCAGTAACTCGGGCATCAGCGCCACGTGCTACGGCAGCG
GCGGGCGCATGGAGGGGCCGCCGCCCACCTACAGCGAGGTCATCGGCCACTACCCGGGGTCCTCCTTCCAGCACCAGCAGAGCAGTGGGC
CGCCCTCCTTGCTGGAGGGGACCCGGCTCCACCACACACACATCGCGCCCCTAGAGAGCGCAGCCATCTGGAGCAAAGAGAAGGATAAAC
AGAAAGGACACCCTCTCTAGGGTCCCCAGGGGGGCCGGGCTGGGGCTGCGTAGGTGAAAAGGCAGAACACTCCGCGCTTCTTAGAAGAGG
AGTGAGAGGAAGGCGGGGGGCGCAGCAACGCATCGTGTGGCCCTCCCCTCCCACCTCCCTGTGTATAAATATTTACATGTGATGTCTGGT
CTGAATGCACAAGCTAAGAGAGCTTGCAAAAAAAAAAAGAAAAAAGAAAAAAAAAAACCACGTTTCTTTGTTGAGCTGTGTCTTGAAGGC
AAAAGAAAAAAAATTTCTACAGTAGTCTTTCTTGTTTCTAGTTGAGCTGCGTGCGTGAATGCTTATTTTCTTTTGTTTATGATAATTTCA
CTTAACTTTAAAGACATATTTGCACAAAACCTTTGTTTAAAGATCTGCAATATTATATATATAAATATATATAAGATAAGAGAAACTGTA
TGTGCGAGGGCAGGAGTATTTTTGTATTAGAAGAGGCCTATTAAAAAAAAAAGTTGTTTTCTGAACTAGAAGAGGAAAAAAATGGCAATT
TTTGAGTGCCAAGTCAGAAAGTGTGTATTACCTTGTAAAGAAAAAAATTACAAAGCAGGGGTTTAGAGTTATTTATATAAATGTTGAGAT
TTTGCACTATTTTTTAATATAAATATGTCAGTGCTTGCTTGATGGAAACTTCTCTTGTGTCTGTTGAGACTTTAAGGGAGAAATGTCGGA
ATTTCAGAGTCGCCTGACGGCAGAGGGTGAGCCCCCGTGGAGTCTGCAGAGAGGCCTTGGCCAGGAGCGGCGGGCTTTCCCGAGGGGCCA
CTGTCCCTGCAGAGTGGATGCTTCTGCCTAGTGACAGGTTATCACCACGTTATATATTCCCTACCGAAGGAGACACCTTTTCCCCCCTGA
CCCAGAACAGCCTTTAAATCACAAGCAAAATAGGAAAGTTAACCACGGAGGCACCGAGTTCCAGGTAGTGGTTTTGCCTTTCCCAAAAAT
GAAAATAAACTGTTACCGAAGGAATTAGTTTTTCCTCTTCTTTTTTCCAACTGTGAAGGTCCCCGTGGGGTGGAGCATGGTGCCCCTCAC
AAGCCGCAGCGGCTGGTGCCCGGGCTACCAGGGACATGCCAGAGGGCTCGATGACTTGTCTCTGCAGGGCGCTTTGGTGGTTGTTCAGCT
GGCTAAAGGTTCACCGGTGAAGGCAGGTGCGGTAACTGCCGCACTGGACCCTAGGAAGCCCCAGGTATTCGCAATCTGACCTCCTCCTGT
CTGTTTCCCTTCACGGATCAATTCTCACTTAAGAGGCCAATAAACAACCCAACATGAAAAGGTGACAAGCCTGGGTTTCTCCCAGGATAG
GTGAAAGGGTTAAAATGAGTAAAGCAGTTGAGCAAACACCAACCCGAGCTTCGGGCGCAGAATTCTTCACCTTCTCTTCCCCTTTCCATC
TCCTTTCCCCGCGGAAACAACGCTTCCCTTCTGGTGTGTCTGTTGATCTGTGTTTTCATTTACATCTCTCTTAGACTCCGCTCTTGTTCT
CCAGGTTTTCACCAGATAGATTTGGGGTTGGCGGGACCTGCTGGTGACGTGCAGGTGAAGGACAGGAAGGGGCATGTGAGCGTAAATAGA
GGTGACCAGAGGAGAGCATGAGGGGTGGGGCTTTGGGACCCACCGGGGCCAGTGGCTGGAGCTTGACGTCTTTCCTCCCCATGGGGGTGG
GAGGGCCCCCAGCTGGAAGAGCAGACTCCCAGCTGCTACCCCCTCCCTTCCCATGGGAGTGGCTTTCCATTTTGGGCAGAATGCTGACTA
GTAGACTAACATAAAAGATATAAAAGGCAATAACTATTGTTTGTGAGCAACTTTTTTATAACTTCCAAAACAAAAACCTGAGCACAGTTT
TGAAGTTCTAGCCACTCGAGCTCATGCATGTGAAACGTGTGCTTTACGAAGGTGGCAGCTGACAGACGTGGGCTCTGCATGCCGCCAGCC
TAGTAGAAAGTTCTCGTTCATTGGCAACAGCAGAACCTGCCTCTCCGTGAAGTCGTCAGCCTAAAATTTGTTTCTCTCTTGAAGAGGATT
CTTTGAAAAGGTCCTGCAGAGAAATCAGTACAGGTTATCCCGAAAGGTACAAGGACGCACTTGTAAAGATGATTAAAACGTATCTTTCCT
TTATGTGACGCGTCTCTAGTGCCTTACTGAAGAAGCAGTGACACTCCCGTCGCTCGGTGAGGACGTTCCCGGACAGTGCCTCACTCACCT
GGGACTGGTATCCCCTCCCAGGGTCCACCAAGGGCTCCTGCTTTTCAGACACCCCATCATCCTCGCGCGTCCTCACCCTGTCTCTACCAG
GGAGGTGCCTAGCTTGGTGAGGTTACTCCTGCTCCTCCAACCTTTTTTTGCCAAGGTTTGTACACGACTCCCATCTAGGCTGAAAACCTA
GAAGTGGACCTTGTGTGTGTGCATGGTGTCAGCCCAAAGCCAGGCTGAGACAGTCCTCATATCCTCTTGAGCCAAACTGTTTGGGTCTCG
TTGCTTCATGGTATGGTCTGGATTTGTGGGAATGGCTTTGCGTGAGAAAGGGGAGGAGAGTGGTTGCTGCCCTCAGCCGGCTTGAGGACA
GAGCCTGTCCCTCTCATGACAACTCAGTGTTGAAGCCCAGTGTCCTCAGCTTCATGTCCAGTGGATGGCAGAAGTTCATGGGGTAGTGGC
CTCTCAAAGGCTGGGCGCATCCCAAGACAGCCAGCAGGTTGTCTCTGGAAACGACCAGAGTTAAGCTCTCGGCTTCTCTGCTGAGGGTGC
ACCCTTTCCTCTAGATGGTAGTTGTCACGTTATCTTTGAAAACTCTTGGACTGCTCCTGAGGAGGCCCTCTTTTCCAGTAGGAAGTTAGA
TGGGGGTTCTCAGAAGTGGCTGATTGGAAGGGGACAAGCTTCGTTTCAGGGGTCTGCCGTTCCATCCTGGTTCAGAGAAGGCCGAGCGTG
GCTTTCTCTAGCCTTGTCACTGTCTCCCTGCCTGTCAATCACCACCTTTCCTCCAGAGGAGGAAAATTATCTCCCCTGCAAAGCCCGGTT
CTACACAGATTTCACAAATTGTGCTAAGAACCGTCCGTGTTCTCAGAAAGCCCAGTGTTTTTGCAAAGAATGAAAAGGGACCCCATATGT
AGCAAAAATCAGGGCTGGGGGAGAGCCGGGTTCATTCCCTGTCCTCATTGGTCGTCCCTATGAATTGTACGTTTCAGAGAAATTTTTTTT
CCTATGTGCAACACGAAGCTTCCAGAACCATAAAATATCCCGTCGATAAGGAAAGAAAATGTCGTTGTTGTTGTTTTTCTGGAAACTGCT
TGAAATCTTGCTGTACTATAGAGCTCAGAAGGACACAGCCCGTCCTCCCCTGCCTGCCTGATTCCATGGCTGTTGTGCTGATTCCAATGC
TTTCACGTTGGTTCCTGGCGTGGGAACTGCTCTCCTTTGCAGCCCCATTTCCCAAGCTCTGTTCAAGTTAAACTTATGTAAGCTTTCCGT
GGCATGCGGGGCGCGCACCCACGTCCCCGCTGCGTAAGACTCTGTATTTGGATGCCAATCCACAGGCCTGAAGAAACTGCTTGTTGTGTA

>60277_60277_1_NRG1-PMEPA1_NRG1_chr8_31498245_ENST00000520407_PMEPA1_chr20_56234753_ENST00000341744_length(amino acids)=499AA_BP=248
MRWRRAPRRSGRPGPRAQRPGSAARSSPPLPLLPLLLLLGTAALAPGAAAGNEAAPAGASVCYSSPPSVGSVQELAQRAAVVIEGKVHPQ
RRQQGALDRKAAAAAGEAGAWGGDREPPAAGPRALGPPAEEPLLAANGTVPSWPTAPVPSAGEPGEEAPYLVKVHQVWAVKAGGLKKDSL
LTVRLGTWGHPAFPSCGRLKEDSRYIFFMEPDANSTSRAPAAFRASFPPLETGRNLKKEVSRVLCKRCAELEFVQIIIIVVVMMVMVVVI
TCLLSHYKLSARSFISRHSQGRRREDALSSEGCLWPSESTVSGNGIPEPQVYAPPRPTDRLAVPPFAQRERFHRFQPTYPYLQHEIDLPP
TISLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRAPPNRTIFDSDLMDSARLGGPCPPSSNSGISATCYGSGGRMEGPPPTYSEVIGH

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Fusion Gene PPI Analysis for NRG1-PMEPA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NRG1-PMEPA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NRG1-PMEPA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource