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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NSD1-EFNA5 (FusionGDB2 ID:60417)

Fusion Gene Summary for NSD1-EFNA5

check button Fusion gene summary
Fusion gene informationFusion gene name: NSD1-EFNA5
Fusion gene ID: 60417
HgeneTgene
Gene symbol

NSD1

EFNA5

Gene ID

64324

1946

Gene namenuclear receptor binding SET domain protein 1ephrin A5
SynonymsARA267|KMT3B|SOTOS|SOTOS1|STOAF1|EFL5|EPLG7|GLC1M|LERK7|RAGS
Cytomap

5q35.3

5q21.3

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specificH3-K36-HMTaseH4-K20-HMTaseNR-binding SET domain-containing proteinandrogen receptor coactivator 267 kDa proteinandrogen receptor-associated coregulator 267androgen receptor-asephrin-A5AL-1LERK-7eph-related receptor tyrosine kinase ligand 7
Modification date2020032120200313
UniProtAcc.

P52803

Ensembl transtripts involved in fusion geneENST00000347982, ENST00000354179, 
ENST00000439151, ENST00000361032, 
ENST00000511258, 		ENST00000510359, 
ENST00000333274, ENST00000509503, 
Fusion gene scores* DoF score23 X 14 X 17=54745 X 3 X 4=60
# samples 376
** MAII scorelog2(37/5474*10)=-3.88699825884864
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/60*10)=0
Context

PubMed: NSD1 [Title/Abstract] AND EFNA5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNSD1(176619020)-EFNA5(106717077), # samples:4
Anticipated loss of major functional domain due to fusion event.NSD1-EFNA5 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NSD1-EFNA5 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
NSD1-EFNA5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NSD1-EFNA5 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
NSD1-EFNA5 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNSD1

GO:0045893

positive regulation of transcription, DNA-templated

11509567

TgeneEFNA5

GO:0006915

apoptotic process

11870224

TgeneEFNA5

GO:0022407

regulation of cell-cell adhesion

11870224

TgeneEFNA5

GO:0022604

regulation of cell morphogenesis

23242526

TgeneEFNA5

GO:0032956

regulation of actin cytoskeleton organization

11870224

TgeneEFNA5

GO:0043087

regulation of GTPase activity

11870224

TgeneEFNA5

GO:0048013

ephrin receptor signaling pathway

11870224

TgeneEFNA5

GO:0051893

regulation of focal adhesion assembly

11870224

TgeneEFNA5

GO:0070507

regulation of microtubule cytoskeleton organization

11870224

TgeneEFNA5

GO:1900025

negative regulation of substrate adhesion-dependent cell spreading

23242526


check buttonFusion gene breakpoints across NSD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EFNA5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5JS-01ANSD1chr5

176619020

-EFNA5chr5

106717077

-
ChimerDB4ACCTCGA-OR-A5JS-01ANSD1chr5

176619020

+EFNA5chr5

106717077

-
ChimerDB4ACCTCGA-OR-A5JSNSD1chr5

176619020

+EFNA5chr5

106717077

-


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Fusion Gene ORF analysis for NSD1-EFNA5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000347982ENST00000510359NSD1chr5

176619020

+EFNA5chr5

106717077

-
5CDS-5UTRENST00000354179ENST00000510359NSD1chr5

176619020

+EFNA5chr5

106717077

-
5CDS-5UTRENST00000439151ENST00000510359NSD1chr5

176619020

+EFNA5chr5

106717077

-
Frame-shiftENST00000347982ENST00000333274NSD1chr5

176619020

+EFNA5chr5

106717077

-
Frame-shiftENST00000354179ENST00000333274NSD1chr5

176619020

+EFNA5chr5

106717077

-
Frame-shiftENST00000439151ENST00000333274NSD1chr5

176619020

+EFNA5chr5

106717077

-
In-frameENST00000347982ENST00000509503NSD1chr5

176619020

+EFNA5chr5

106717077

-
In-frameENST00000354179ENST00000509503NSD1chr5

176619020

+EFNA5chr5

106717077

-
In-frameENST00000439151ENST00000509503NSD1chr5

176619020

+EFNA5chr5

106717077

-
intron-3CDSENST00000361032ENST00000333274NSD1chr5

176619020

+EFNA5chr5

106717077

-
intron-3CDSENST00000361032ENST00000509503NSD1chr5

176619020

+EFNA5chr5

106717077

-
intron-3CDSENST00000511258ENST00000333274NSD1chr5

176619020

+EFNA5chr5

106717077

-
intron-3CDSENST00000511258ENST00000509503NSD1chr5

176619020

+EFNA5chr5

106717077

-
intron-5UTRENST00000361032ENST00000510359NSD1chr5

176619020

+EFNA5chr5

106717077

-
intron-5UTRENST00000511258ENST00000510359NSD1chr5

176619020

+EFNA5chr5

106717077

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000354179NSD1chr5176619020+ENST00000509503EFNA5chr5106717077-555416160537125
ENST00000439151NSD1chr5176619020+ENST00000509503EFNA5chr5106717077-12471108451229394
ENST00000347982NSD1chr5176619020+ENST00000509503EFNA5chr5106717077-496357101478125

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000354179ENST00000509503NSD1chr5176619020+EFNA5chr5106717077-0.0287729450.9712271
ENST00000439151ENST00000509503NSD1chr5176619020+EFNA5chr5106717077-0.0012539730.99874604
ENST00000347982ENST00000509503NSD1chr5176619020+EFNA5chr5106717077-0.0346927940.9653072

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Fusion Genomic Features for NSD1-EFNA5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NSD1-EFNA5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:176619020/chr5:106717077)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EFNA5

P52803

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion. {ECO:0000269|PubMed:10601038, ECO:0000269|PubMed:11870224}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNSD1chr5:176619020chr5:106717077ENST00000347982+4242207_2421852428.0Compositional biasNote=Pro-rich
HgeneNSD1chr5:176619020chr5:106717077ENST00000354179+4242207_2421852428.0Compositional biasNote=Pro-rich
HgeneNSD1chr5:176619020chr5:106717077ENST00000361032+1202207_242102594.0Compositional biasNote=Pro-rich
HgeneNSD1chr5:176619020chr5:106717077ENST00000439151+3232207_24213542697.0Compositional biasNote=Pro-rich
HgeneNSD1chr5:176619020chr5:106717077ENST00000347982+4241756_1818852428.0DomainPWWP 2
HgeneNSD1chr5:176619020chr5:106717077ENST00000347982+4241890_1940852428.0DomainAWS
HgeneNSD1chr5:176619020chr5:106717077ENST00000347982+4241942_2059852428.0DomainSET
HgeneNSD1chr5:176619020chr5:106717077ENST00000347982+4242066_2082852428.0DomainPost-SET
HgeneNSD1chr5:176619020chr5:106717077ENST00000347982+424323_388852428.0DomainPWWP 1
HgeneNSD1chr5:176619020chr5:106717077ENST00000354179+4241756_1818852428.0DomainPWWP 2
HgeneNSD1chr5:176619020chr5:106717077ENST00000354179+4241890_1940852428.0DomainAWS
HgeneNSD1chr5:176619020chr5:106717077ENST00000354179+4241942_2059852428.0DomainSET
HgeneNSD1chr5:176619020chr5:106717077ENST00000354179+4242066_2082852428.0DomainPost-SET
HgeneNSD1chr5:176619020chr5:106717077ENST00000354179+424323_388852428.0DomainPWWP 1
HgeneNSD1chr5:176619020chr5:106717077ENST00000361032+1201756_181802594.0DomainPWWP 2
HgeneNSD1chr5:176619020chr5:106717077ENST00000361032+1201890_194002594.0DomainAWS
HgeneNSD1chr5:176619020chr5:106717077ENST00000361032+1201942_205902594.0DomainSET
HgeneNSD1chr5:176619020chr5:106717077ENST00000361032+1202066_208202594.0DomainPost-SET
HgeneNSD1chr5:176619020chr5:106717077ENST00000361032+120323_38802594.0DomainPWWP 1
HgeneNSD1chr5:176619020chr5:106717077ENST00000439151+3231756_18183542697.0DomainPWWP 2
HgeneNSD1chr5:176619020chr5:106717077ENST00000439151+3231890_19403542697.0DomainAWS
HgeneNSD1chr5:176619020chr5:106717077ENST00000439151+3231942_20593542697.0DomainSET
HgeneNSD1chr5:176619020chr5:106717077ENST00000439151+3232066_20823542697.0DomainPost-SET
HgeneNSD1chr5:176619020chr5:106717077ENST00000439151+323323_3883542697.0DomainPWWP 1
HgeneNSD1chr5:176619020chr5:106717077ENST00000347982+4241952_1954852428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:106717077ENST00000347982+4241994_1997852428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:106717077ENST00000347982+4242020_2021852428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:106717077ENST00000347982+4242060_2066852428.0RegionNote=Inhibits enzyme activity in the absence of bound histone
HgeneNSD1chr5:176619020chr5:106717077ENST00000354179+4241952_1954852428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:106717077ENST00000354179+4241994_1997852428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:106717077ENST00000354179+4242020_2021852428.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:106717077ENST00000354179+4242060_2066852428.0RegionNote=Inhibits enzyme activity in the absence of bound histone
HgeneNSD1chr5:176619020chr5:106717077ENST00000361032+1201952_195402594.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:106717077ENST00000361032+1201994_199702594.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:106717077ENST00000361032+1202020_202102594.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:106717077ENST00000361032+1202060_206602594.0RegionNote=Inhibits enzyme activity in the absence of bound histone
HgeneNSD1chr5:176619020chr5:106717077ENST00000439151+3231952_19543542697.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:106717077ENST00000439151+3231994_19973542697.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:106717077ENST00000439151+3232020_20213542697.0RegionNote=S-adenosyl-L-methionine binding
HgeneNSD1chr5:176619020chr5:106717077ENST00000439151+3232060_20663542697.0RegionNote=Inhibits enzyme activity in the absence of bound histone
HgeneNSD1chr5:176619020chr5:106717077ENST00000347982+4241543_1589852428.0Zinc fingerPHD-type 1
HgeneNSD1chr5:176619020chr5:106717077ENST00000347982+4241590_1646852428.0Zinc fingerPHD-type 2
HgeneNSD1chr5:176619020chr5:106717077ENST00000347982+4241707_1751852428.0Zinc fingerPHD-type 3
HgeneNSD1chr5:176619020chr5:106717077ENST00000347982+4242118_2165852428.0Zinc fingerPHD-type 4%3B atypical
HgeneNSD1chr5:176619020chr5:106717077ENST00000354179+4241543_1589852428.0Zinc fingerPHD-type 1
HgeneNSD1chr5:176619020chr5:106717077ENST00000354179+4241590_1646852428.0Zinc fingerPHD-type 2
HgeneNSD1chr5:176619020chr5:106717077ENST00000354179+4241707_1751852428.0Zinc fingerPHD-type 3
HgeneNSD1chr5:176619020chr5:106717077ENST00000354179+4242118_2165852428.0Zinc fingerPHD-type 4%3B atypical
HgeneNSD1chr5:176619020chr5:106717077ENST00000361032+1201543_158902594.0Zinc fingerPHD-type 1
HgeneNSD1chr5:176619020chr5:106717077ENST00000361032+1201590_164602594.0Zinc fingerPHD-type 2
HgeneNSD1chr5:176619020chr5:106717077ENST00000361032+1201707_175102594.0Zinc fingerPHD-type 3
HgeneNSD1chr5:176619020chr5:106717077ENST00000361032+1202118_216502594.0Zinc fingerPHD-type 4%3B atypical
HgeneNSD1chr5:176619020chr5:106717077ENST00000439151+3231543_15893542697.0Zinc fingerPHD-type 1
HgeneNSD1chr5:176619020chr5:106717077ENST00000439151+3231590_16463542697.0Zinc fingerPHD-type 2
HgeneNSD1chr5:176619020chr5:106717077ENST00000439151+3231707_17513542697.0Zinc fingerPHD-type 3
HgeneNSD1chr5:176619020chr5:106717077ENST00000439151+3232118_21653542697.0Zinc fingerPHD-type 4%3B atypical
TgeneEFNA5chr5:176619020chr5:106717077ENST000003332743529_162188229.0DomainEphrin RBD


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Fusion Gene Sequence for NSD1-EFNA5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>60417_60417_1_NSD1-EFNA5_NSD1_chr5_176619020_ENST00000347982_EFNA5_chr5_106717077_ENST00000509503_length(transcript)=496nt_BP=357nt
CCTCCGCCTCCCCTCAGGTTGATGCCGGCCCAGGATGGATCAGACCTGTGAACTACCCAGAAGAAATTGTCTGCTGCCCTTTTCCAATCC
AGTGAATTTAGATGCCCCTGAAGACAAGGACAGCCCTTTCGGATGATCCAGATTCCAGTACCAGTACATTAGGAAACATGCTAGAATTAC
CTGGAACTTCATCATCATCTACTTCACAGGAATTGCCATTTTGTCAACCTAAGAAAAAGTCTACGCCACTGAAGTATGAAGTTGGAGATC
TCATCTGGGCAAAATTCAAGAGACGCCCATGGTGGCCCTGCAGGATTTGTTCTGATCCGTTGATTAACACACATTCAAAAATGAAAGATG
ACACCGTACATGAGTCAGCCGAGCCATCCCGCGGCGAGAACGCGGCACAAACACCAAGGATACCCAGCCGCCTTTTGGCAATCCTACTGT

>60417_60417_1_NSD1-EFNA5_NSD1_chr5_176619020_ENST00000347982_EFNA5_chr5_106717077_ENST00000509503_length(amino acids)=125AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKDDTVH

--------------------------------------------------------------
>60417_60417_2_NSD1-EFNA5_NSD1_chr5_176619020_ENST00000354179_EFNA5_chr5_106717077_ENST00000509503_length(transcript)=555nt_BP=416nt
GGCCGGGTAGGGGGTTCGCCTGCGGCCGCGTCTGCTCGGGGCCTGAGGCCTCGAAGACCCCAGCCCAAGCCCCCAGGTTGATGCCGGCCC
AGGATGGATCAGACCTGTGAACTACCCAGAAGAAATTGTCTGCTGCCCTTTTCCAATCCAGTGAATTTAGATGCCCCTGAAGACAAGGAC
AGCCCTTTCGGATGATCCAGATTCCAGTACCAGTACATTAGGAAACATGCTAGAATTACCTGGAACTTCATCATCATCTACTTCACAGGA
ATTGCCATTTTGTCAACCTAAGAAAAAGTCTACGCCACTGAAGTATGAAGTTGGAGATCTCATCTGGGCAAAATTCAAGAGACGCCCATG
GTGGCCCTGCAGGATTTGTTCTGATCCGTTGATTAACACACATTCAAAAATGAAAGATGACACCGTACATGAGTCAGCCGAGCCATCCCG
CGGCGAGAACGCGGCACAAACACCAAGGATACCCAGCCGCCTTTTGGCAATCCTACTGTTCCTCCTGGCGATGCTTTTGACATTATAGCA

>60417_60417_2_NSD1-EFNA5_NSD1_chr5_176619020_ENST00000354179_EFNA5_chr5_106717077_ENST00000509503_length(amino acids)=125AA_BP=85
MPLKTRTALSDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKDDTVH

--------------------------------------------------------------
>60417_60417_3_NSD1-EFNA5_NSD1_chr5_176619020_ENST00000439151_EFNA5_chr5_106717077_ENST00000509503_length(transcript)=1247nt_BP=1108nt
GCTGGCCCGGGAGGGGGCGCGGGGCACGGTTGATGCCGGCCCAGGATGGATCAGACCTGTGAACTACCCAGAAGAAATTGTCTGCTGCCC
TTTTCCAATCCAGTGAATTTAGATGCCCCTGAAGACAAGGACAGCCCTTTCGGTAATGGTCAATCCAATTTTTCTGAGCCACTTAATGGG
TGTACTATGCAGTTATCGACTGTCAGTGGAACATCCCAAAATGCTTATGGACAAGATTCTCCATCTTGTTACATTCCACTGCGGAGACTA
CAGGATTTGGCCTCCATGATCAATGTAGAGTATTTAAATGGGTCTGCTGATGGATCAGAATCCTTTCAAGACCCTGAAAAAAGTGATTCA
AGAGCTCAGACGCCAATTGTTTGCACTTCCTTGAGTCCTGGTGGTCCTACAGCACTTGCTATGAAACAGGAACCCTCTTGTAATAACTCC
CCTGAACTCCAGGTAAAAGTAACAAAGACTATCAAGAATGGCTTTCTGCACTTTGAGAATTTTACTTGTGTGGACGATGCAGATGTAGAT
TCTGAAATGGACCCAGAACAGCCAGTCACAGAGGATGAGAGTATAGAGGAGATCTTTGAGGAAACTCAGACCAATGCCACCTGCAATTAT
GAGACTAAATCAGAGAATGGTGTAAAAGTGGCCATGGGAAGTGAACAAGACAGCACACCAGAGAGTAGACACGGTGCAGTCAAATCGCCA
TTCTTGCCATTAGCTCCTCAGACTGAAACACAGAAAAATAAGCAAAGAAATGAAGTGGACGGCAGCAATGAAAAAGCAGCCCTTCTCCCA
GCCCCCTTTTCACTAGGAGACACAAACATTACAATAGAAGAGCAATTAAACTCAATAAATTTATCTTTTCAGGATGATCCAGATTCCAGT
ACCAGTACATTAGGAAACATGCTAGAATTACCTGGAACTTCATCATCATCTACTTCACAGGAATTGCCATTTTGTCAACCTAAGAAAAAG
TCTACGCCACTGAAGTATGAAGTTGGAGATCTCATCTGGGCAAAATTCAAGAGACGCCCATGGTGGCCCTGCAGGATTTGTTCTGATCCG
TTGATTAACACACATTCAAAAATGAAAGATGACACCGTACATGAGTCAGCCGAGCCATCCCGCGGCGAGAACGCGGCACAAACACCAAGG

>60417_60417_3_NSD1-EFNA5_NSD1_chr5_176619020_ENST00000439151_EFNA5_chr5_106717077_ENST00000509503_length(amino acids)=394AA_BP=354
MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDSPSCYIPLRRLQDLASMINVEYLNGS
ADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESI
EEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQ
LNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKDDTVHE

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Fusion Gene PPI Analysis for NSD1-EFNA5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NSD1-EFNA5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NSD1-EFNA5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource