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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ARHGAP28-MORF4L2 (FusionGDB2 ID:6053)

Fusion Gene Summary for ARHGAP28-MORF4L2

Fusion gene summary

Fusion gene information	Fusion gene name: ARHGAP28-MORF4L2
	Fusion gene ID: 6053
		Hgene	Tgene
	Gene symbol	ARHGAP28	MORF4L2
	Gene ID	79822	9643
	Gene name	Rho GTPase activating protein 28	mortality factor 4 like 2
	Synonyms	-	MORFL2\|MRGX
	Cytomap	18p11.31	Xq22.2
	Type of gene	protein-coding	protein-coding
	Description	rho GTPase-activating protein 28rho-type GTPase-activating protein 28	mortality factor 4-like protein 2MORF-related gene X proteinMSL3-2 proteinprotein MSL3-2transcription factor-like protein MRGX
	Modification date	20200313	20200313
	UniProtAcc	Q9P2N2	Q15014
	Ensembl transtripts involved in fusion gene	ENST00000262227, ENST00000314319, ENST00000383472, ENST00000400091, ENST00000418986, ENST00000419673, ENST00000531294, ENST00000532996,	ENST00000360458, ENST00000422154, ENST00000423833, ENST00000433176, ENST00000441076, ENST00000451301, ENST00000492116,
Fusion gene scores	* DoF score	3 X 3 X 3=27	4 X 4 X 2=32
	# samples	3	4
	** MAII score	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ARHGAP28 [Title/Abstract] AND MORF4L2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ARHGAP28(6842955)-MORF4L2(102936686), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ARHGAP28 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MORF4L2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	FN079004	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+

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Fusion Gene ORF analysis for ARHGAP28-MORF4L2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000262227	ENST00000360458	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000262227	ENST00000422154	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000262227	ENST00000423833	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000262227	ENST00000433176	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000262227	ENST00000441076	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000262227	ENST00000451301	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000262227	ENST00000492116	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000314319	ENST00000360458	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000314319	ENST00000422154	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000314319	ENST00000423833	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000314319	ENST00000433176	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000314319	ENST00000441076	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000314319	ENST00000451301	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000314319	ENST00000492116	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000383472	ENST00000360458	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000383472	ENST00000422154	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000383472	ENST00000423833	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000383472	ENST00000433176	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000383472	ENST00000441076	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000383472	ENST00000451301	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000383472	ENST00000492116	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000400091	ENST00000360458	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000400091	ENST00000422154	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000400091	ENST00000423833	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000400091	ENST00000433176	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000400091	ENST00000441076	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000400091	ENST00000451301	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000400091	ENST00000492116	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000418986	ENST00000360458	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000418986	ENST00000422154	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000418986	ENST00000423833	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000418986	ENST00000433176	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000418986	ENST00000441076	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000418986	ENST00000451301	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000418986	ENST00000492116	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000419673	ENST00000360458	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000419673	ENST00000422154	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000419673	ENST00000423833	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000419673	ENST00000433176	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000419673	ENST00000441076	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000419673	ENST00000451301	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000419673	ENST00000492116	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000531294	ENST00000360458	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000531294	ENST00000422154	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000531294	ENST00000423833	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000531294	ENST00000433176	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000531294	ENST00000441076	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000531294	ENST00000451301	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000531294	ENST00000492116	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000532996	ENST00000360458	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000532996	ENST00000422154	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000532996	ENST00000423833	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000532996	ENST00000433176	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000532996	ENST00000441076	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000532996	ENST00000451301	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+
intron-intron	ENST00000532996	ENST00000492116	ARHGAP28	chr18	6842955	+	MORF4L2	chrX	102936686	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for ARHGAP28-MORF4L2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARHGAP28-MORF4L2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:6842955/:102936686)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ARHGAP28 Q9P2N2	MORF4L2 Q15014
FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.	FUNCTION: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ARHGAP28-MORF4L2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ARHGAP28-MORF4L2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ARHGAP28-MORF4L2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ARHGAP28-MORF4L2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source