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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NSMCE2-SNTB1 (FusionGDB2 ID:60531)

Fusion Gene Summary for NSMCE2-SNTB1

check button Fusion gene summary
Fusion gene informationFusion gene name: NSMCE2-SNTB1
Fusion gene ID: 60531
HgeneTgene
Gene symbol

NSMCE2

SNTB1

Gene ID

286053

6641

Gene nameNSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligasesyntrophin beta 1
SynonymsC8orf36|MMS21|NSE2|ZMIZ759-DAP|A1B|BSYN2|DAPA1B|SNT2|SNT2B1|TIP-43
Cytomap

8q24.13

8q24.12

Type of geneprotein-codingprotein-coding
DescriptionE3 SUMO-protein ligase NSE2E3 SUMO-protein transferase NSE2NSMCE2/PVT1 fusionPVT1/NSMCE2 fusionmethyl methanesulfonate sensitivity gene 21non-SMC element 2, MMS21 homolognon-structural maintenance of chromosomes element 2 homologzinc finger, MIZ-tybeta-1-syntrophin59 kDa dystrophin-associated protein A1 basic component 1dystrophin-associated protein A1, 59kD, basic component 1syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)syntrophin-2tax interaction protein 43
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000287437, ENST00000517315, 
ENST00000522563, ENST00000521460, 
ENST00000519177, ENST00000395601, 
ENST00000517992, 
Fusion gene scores* DoF score23 X 24 X 7=38646 X 6 X 6=216
# samples 298
** MAII scorelog2(29/3864*10)=-3.73597028882084
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/216*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NSMCE2 [Title/Abstract] AND SNTB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNSMCE2(126163519)-SNTB1(121587465), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NSMCE2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SNTB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A08B-01ANSMCE2chr8

126163519

-SNTB1chr8

121587465

-
ChimerDB4BRCATCGA-A8-A08B-01ANSMCE2chr8

126163519

+SNTB1chr8

121587465

-


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Fusion Gene ORF analysis for NSMCE2-SNTB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000287437ENST00000519177NSMCE2chr8

126163519

+SNTB1chr8

121587465

-
5CDS-5UTRENST00000517315ENST00000519177NSMCE2chr8

126163519

+SNTB1chr8

121587465

-
5CDS-5UTRENST00000522563ENST00000519177NSMCE2chr8

126163519

+SNTB1chr8

121587465

-
In-frameENST00000287437ENST00000395601NSMCE2chr8

126163519

+SNTB1chr8

121587465

-
In-frameENST00000287437ENST00000517992NSMCE2chr8

126163519

+SNTB1chr8

121587465

-
In-frameENST00000517315ENST00000395601NSMCE2chr8

126163519

+SNTB1chr8

121587465

-
In-frameENST00000517315ENST00000517992NSMCE2chr8

126163519

+SNTB1chr8

121587465

-
In-frameENST00000522563ENST00000395601NSMCE2chr8

126163519

+SNTB1chr8

121587465

-
In-frameENST00000522563ENST00000517992NSMCE2chr8

126163519

+SNTB1chr8

121587465

-
intron-3CDSENST00000521460ENST00000395601NSMCE2chr8

126163519

+SNTB1chr8

121587465

-
intron-3CDSENST00000521460ENST00000517992NSMCE2chr8

126163519

+SNTB1chr8

121587465

-
intron-5UTRENST00000521460ENST00000519177NSMCE2chr8

126163519

+SNTB1chr8

121587465

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000287437NSMCE2chr8126163519+ENST00000395601SNTB1chr8121587465-42334801201100326
ENST00000287437NSMCE2chr8126163519+ENST00000517992SNTB1chr8121587465-14574801201100326
ENST00000522563NSMCE2chr8126163519+ENST00000395601SNTB1chr8121587465-4120367103987294
ENST00000522563NSMCE2chr8126163519+ENST00000517992SNTB1chr8121587465-1344367103987294
ENST00000517315NSMCE2chr8126163519+ENST00000395601SNTB1chr8121587465-4036283199903234
ENST00000517315NSMCE2chr8126163519+ENST00000517992SNTB1chr8121587465-1260283199903234

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000287437ENST00000395601NSMCE2chr8126163519+SNTB1chr8121587465-0.0009395620.99906045
ENST00000287437ENST00000517992NSMCE2chr8126163519+SNTB1chr8121587465-0.0053616150.9946384
ENST00000522563ENST00000395601NSMCE2chr8126163519+SNTB1chr8121587465-0.000947260.9990527
ENST00000522563ENST00000517992NSMCE2chr8126163519+SNTB1chr8121587465-0.0057287330.9942713
ENST00000517315ENST00000395601NSMCE2chr8126163519+SNTB1chr8121587465-0.0013224180.99867755
ENST00000517315ENST00000517992NSMCE2chr8126163519+SNTB1chr8121587465-0.0063057980.9936941

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Fusion Genomic Features for NSMCE2-SNTB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NSMCE2-SNTB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:126163519/chr8:121587465)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSNTB1chr8:126163519chr8:121587465ENST0000039560138482_538332539.0DomainNote=SU
TgeneSNTB1chr8:126163519chr8:121587465ENST0000051799227482_538332539.0DomainNote=SU
TgeneSNTB1chr8:126163519chr8:121587465ENST0000039560138518_538332539.0RegionCalmodulin-binding
TgeneSNTB1chr8:126163519chr8:121587465ENST0000051799227518_538332539.0RegionCalmodulin-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNSMCE2chr8:126163519chr8:121587465ENST00000287437+48154_23688248.0Zinc fingerSP-RING-type
HgeneNSMCE2chr8:126163519chr8:121587465ENST00000522563+37154_23688248.0Zinc fingerSP-RING-type
TgeneSNTB1chr8:126163519chr8:121587465ENST00000395601382_10332539.0Compositional biasNote=Poly-Ala
TgeneSNTB1chr8:126163519chr8:121587465ENST00000517992272_10332539.0Compositional biasNote=Poly-Ala
TgeneSNTB1chr8:126163519chr8:121587465ENST0000039560138112_195332539.0DomainPDZ
TgeneSNTB1chr8:126163519chr8:121587465ENST000003956013819_298332539.0DomainPH 1
TgeneSNTB1chr8:126163519chr8:121587465ENST0000039560138322_433332539.0DomainPH 2
TgeneSNTB1chr8:126163519chr8:121587465ENST0000051799227112_195332539.0DomainPDZ
TgeneSNTB1chr8:126163519chr8:121587465ENST000005179922719_298332539.0DomainPH 1
TgeneSNTB1chr8:126163519chr8:121587465ENST0000051799227322_433332539.0DomainPH 2


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Fusion Gene Sequence for NSMCE2-SNTB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>60531_60531_1_NSMCE2-SNTB1_NSMCE2_chr8_126163519_ENST00000287437_SNTB1_chr8_121587465_ENST00000395601_length(transcript)=4233nt_BP=480nt
GCCCGCTCTCACTTTTCAGCGGCAGGCGAAGGGGGCTGAGGAAAGGAGGTGGGTCTAGGCAGGGGAAATTGGGGTGCCACCAGACGGAGA
CAGCTTGGACTACCAGAATCAAGCACTCTTTTGGAAGAGGGTAATCTCTCTCCAAAAACTGAGGACACTTACCTTCCCCATATATTGAGT
CCAGCTGTGTTTGGTGGCCCAGGTACTAATTTCAAGATGCCAGGACGTTCCAGTTCAAATTCAGGTTCAACTGGTTTCATCTCCTTCAGT
GGTGTAGAGTCTGCTCTCTCCTCCTTGAAAAACTTCCAAGCCTGTATCAACTCTGGTATGGACACAGCTTCTAGTGTTGCTTTGGATCTT
GTGGAAAGTCAGACTGAAGTGAGTAGTGAATATAGTATGGACAAGGCAATGGTTGAATTTGCTACATTGGATCGGCAACTAAACCATTAT
GTAAAGGCTGTTCAATCTACAATAAATCATGTGCCAGGGGAGAGCAAGAAACAGTGGAAACCAGCCCTGGTTGTGCTGACTGAGAAAGAC
CTTTTAATCTATGACAGCATGCCACGGAGGAAGGAAGCCTGGTTCAGCCCAGTTCACACATACCCTCTTCTTGCCACCAGGCTGGTCCAT
TCAGGTCCAGGAAAGGGATCACCCCAGGCTGGTGTGGATCTGTCCTTTGCAACGCGAACTGGTACCAGGCAAGGGATTGAAACACATCTC
TTCAGAGCAGAGACCAGCAGGGACCTCTCCCACTGGACAAGGAGCATAGTACAGGGTTGCCACAATTCTGCTGAACTCATTGCTGAAATC
AGCACTGCTTGCACCTACAAAAACCAGGAGTGCCGTTTGACCATACATTATGAGAATGGATTTTCTATTACCACTGAACCACAGGAGGGT
GCCTTTCCCAAGACCATCATACAGTCTCCTTATGAAAAGCTCAAAATGTCTTCAGATGATGGAATCAGGATGCTGTATTTAGATTTTGGA
GGCAAAGATGGAGAGATTCAACTGGACCTTCATTCCTGCCCCAAGCCAATTGTTTTCATCATTCATTCCTTCCTGTCAGCTAAGATTACA
AGACTGGGCTTGGTGGCCTGAAGACAGGGGTGACTTGCCTTTGAGAAAAGAAGGGCTGCAATGCCACCAGAGAACGTGATGTCAGACACC
ATCTGTAGTGAGCAGCGCACCAGATGTAGCGTGCTACAGTCAGCTTTAGCTCTCAAGAGTCGTATGTAACTGTCCCAGACTCCTCTGTCA
GTTTCAGCAACTACAAGGGATACCCTGCGAAAGTACCATGAGAAATATCAGAGTAAAACTTTCTAGAACAGTACAAGGTTAAAGAGGTGA
GGTGACGGGAAATACACAGCATAGCTTTGAAATAATGACAACCAAGGACATGACCATTAGAACAGCATGTGCAGATCTTAATCATCCCAG
TTCCTAGGCAACTTGTTCACCAGGTACGCAAGGGCCGAATAGTTGAGAAATGGACATTCTTACCTACTCCTCCTAGCCCCCTATCCCCAG
TAACAGTGATCCCTTTTCTTATTGTGATTTATTTCCTAATTCTTGCTGAGTTGACTTTCCCTTGTAGGAAAAGAAAAATATTTCAAATAG
AAACCCACCTTTTATTTAAGTATGAAGCAGCTGTTACTTTTTAAAAAATGAATTATCTTTCAATGGTGTAGAATGATTCCAAAGTGTCTC
CATTAGCATATACTGAGCAGGAATTAAATAAAGCATCAGATACTGATCTGAGCTGTAAGCTGGTAGAATCTGAGCCAAAGTAGACTGCTT
AAATTGATAAGCTTTGCTAAAGAGTTGTATGCACAAAGGATGATTAATTCTGGGACTATACTCACACCAAGGTCTGCTGTCTTATAGCCA
AGAATTACAGCTTTATTTATAGAGAGTGAATTATGGGTATTTTTTCAGAAAATATTGTCATCTGATATACACATAAAACAACTCACATTG
TTGGAGTTAACTAATTATCCCCATTTCATGGTTTTCAGTGGCAACTTACTGACCCTTGTTTTTGCCTGTGCTTGTATGCATGCATTTTCA
AGCAAGTAATAAAGCAGCCTCATTTAATTCTGGATAATGCTGGGTTTTACATATAGACTGAATGCTATAATCAAATCTATTGACAGTATC
TGCAGTTCTTTCAGAATTCCAGGGAAATAATATAACGACCTGATATCTTTCTACAGGAATATTTTCAGACATTATATAGCACATTACTGA
TTTAATGCTTTTACTTTTATCTTTCAAAACAAATTCACTAAAAATAACACCTATTGATTTTGAAGTCACTTTTCTCAAACCTTGAAAATG
AGCTCTAGGATCTCTATAAACATTTCTAACACTTTTCCTGTAGTTTACATAGACAGACATCTGTTGTTAGACCTGTGTGTTTTTAAAGAA
TCATATGTTAACAAATACCCATGCAAAGAGCTTCAAAAAGTGAAACCGTGTTAAAGGAACACAATTTTTCTCACTCAGACATATTTGTTT
ATTGAATTGCAAAGTTTTATTTTAAATCAGCATTTCCCCAAAGAATATATCATATGACGCTAGTTCCAAGGGGCTTGACTGAGTGGTGTT
TTGCTGGGGGGAGACAGGGGTTTGTTAATACACTTTACTAAATACTGAGCTGAAAAATGTTAAATAGATTTCACGATTGCCTCCTTGAAG
ATTTTAAAGTTCATTGTGGTTCTTCAAGGCGAAATCCGGTGAACCATTCCTCACACTTACCTACAGGACTCTTTTCTAATGGAGCATCTT
GTGAAGCTAGTGGGTTTTTTTGTTGTTGTTATTTGTTTTTTTTTTTTAATGCTTTAGAAAACACAGCTTTAGGATATTGACTTTTTGTTT
ATTTCTATTTTCAAATGCTGAAAAGTCAAGTCCCAGTTTGAATACCATAGAAAAGCTTTGATGCATTTGTAAATTATATTGCACTCTTTC
ACTATATATTTTCAAAATCACTGGAATGTTGTTATACAAGAGAATTATAATTGTGTATTGTAAATAACATATTAAAATACATATATTAAT
GCCAATAGTTAAATTCAACAATATGTAATCTAAGGTGCTCGGTTCTACATGAAGTATGAGTTAACTGCTCATAATTAAGTTGCCAAGATT
CTATTATATATTTATAGACAAATTAAAATGATCATAATTACAAATATGATTTCTTTATCACTTAAGCTTTGGGCTGATTAATATCTGTGT
GGGGGTCAATGGAAACTACATTCTCTACATTTATAAACATTTAATTTAATTATTTATATTTTAGGAAAATATATTTGAATAAAATTAATG
CATTTTCTAGAGTAAATTAAAATGTTATTAGCAAGAAATAGAAAATTTGACTAAGATAATTGTGTATATGAATCATTTTTCCCCCAAGTT
AAAATGTATCATAATAGAGAGGCTCTAATGAATCAATTTCCAATACTCATTTCTTTCTTATTTTGAATTCAAGTTACAATGACTTTACAC
TGTAGATTTTAATCTTGTCTGATGTGTGCTGGTGTGTATGACACAAACTCATAAGTCTGGATCATGCTTGGGTACAGTCAATGAATCAAC
CGAGTCACTTTGAGGAATTTGTTTTTGTCCAATTTGCTCTGTGCTCAATCCCATGAATTATTAAATTTACAATGTTTGTCCCCAAATGAA
AACCAATATAAATGAATGATGTTTTAATCTGTACTTTATGGGAAGTTGCCTATTTGTCAGTAGATGTGGTTAAGTGAGTCCTCTGGTGCA
GTGACATCCTTTTAAGCCATCTCATAGGGATTTAAAGAAGGCCAATAGGAATATAGATATTGGTTTTTCTTTCTCTGACTTGAACTAAGT
AGGAGAAACCAAACCATAAACCTATTACAAACTACCCAGGCAGAGGCATTTACTTAATTCATCAACTAGTGCAATTAAAACCCTGAAAAC
ACATGATCCTTGTTGACTCTGCTTGGTTGAAGCAGGAAAGAATGGTCTTGATGGTCAGAAAGTTTTAAAATTAATGGGCAGGGCCTTTCT
GGACCCTGTTTTCCAAACACGTTAGATATTCCGTCTTGAGGGGATTGGAGTAGGCTACAGTGAGGGGGTAATTTTTGGATGTATCTGGAC
TTTTAAAAAATGTGCCTATATTTATAGCACCATGAATATTATGTAAAATTTATATATGAATTAAATAAATATTCACCTCTGATTTCCAGT

>60531_60531_1_NSMCE2-SNTB1_NSMCE2_chr8_126163519_ENST00000287437_SNTB1_chr8_121587465_ENST00000395601_length(amino acids)=326AA_BP=120
MEEGNLSPKTEDTYLPHILSPAVFGGPGTNFKMPGRSSSNSGSTGFISFSGVESALSSLKNFQACINSGMDTASSVALDLVESQTEVSSE
YSMDKAMVEFATLDRQLNHYVKAVQSTINHVPGESKKQWKPALVVLTEKDLLIYDSMPRRKEAWFSPVHTYPLLATRLVHSGPGKGSPQA
GVDLSFATRTGTRQGIETHLFRAETSRDLSHWTRSIVQGCHNSAELIAEISTACTYKNQECRLTIHYENGFSITTEPQEGAFPKTIIQSP

--------------------------------------------------------------
>60531_60531_2_NSMCE2-SNTB1_NSMCE2_chr8_126163519_ENST00000287437_SNTB1_chr8_121587465_ENST00000517992_length(transcript)=1457nt_BP=480nt
GCCCGCTCTCACTTTTCAGCGGCAGGCGAAGGGGGCTGAGGAAAGGAGGTGGGTCTAGGCAGGGGAAATTGGGGTGCCACCAGACGGAGA
CAGCTTGGACTACCAGAATCAAGCACTCTTTTGGAAGAGGGTAATCTCTCTCCAAAAACTGAGGACACTTACCTTCCCCATATATTGAGT
CCAGCTGTGTTTGGTGGCCCAGGTACTAATTTCAAGATGCCAGGACGTTCCAGTTCAAATTCAGGTTCAACTGGTTTCATCTCCTTCAGT
GGTGTAGAGTCTGCTCTCTCCTCCTTGAAAAACTTCCAAGCCTGTATCAACTCTGGTATGGACACAGCTTCTAGTGTTGCTTTGGATCTT
GTGGAAAGTCAGACTGAAGTGAGTAGTGAATATAGTATGGACAAGGCAATGGTTGAATTTGCTACATTGGATCGGCAACTAAACCATTAT
GTAAAGGCTGTTCAATCTACAATAAATCATGTGCCAGGGGAGAGCAAGAAACAGTGGAAACCAGCCCTGGTTGTGCTGACTGAGAAAGAC
CTTTTAATCTATGACAGCATGCCACGGAGGAAGGAAGCCTGGTTCAGCCCAGTTCACACATACCCTCTTCTTGCCACCAGGCTGGTCCAT
TCAGGTCCAGGAAAGGGATCACCCCAGGCTGGTGTGGATCTGTCCTTTGCAACGCGAACTGGTACCAGGCAAGGGATTGAAACACATCTC
TTCAGAGCAGAGACCAGCAGGGACCTCTCCCACTGGACAAGGAGCATAGTACAGGGTTGCCACAATTCTGCTGAACTCATTGCTGAAATC
AGCACTGCTTGCACCTACAAAAACCAGGAGTGCCGTTTGACCATACATTATGAGAATGGATTTTCTATTACCACTGAACCACAGGAGGGT
GCCTTTCCCAAGACCATCATACAGTCTCCTTATGAAAAGCTCAAAATGTCTTCAGATGATGGAATCAGGATGCTGTATTTAGATTTTGGA
GGCAAAGATGGAGAGATTCAACTGGACCTTCATTCCTGCCCCAAGCCAATTGTTTTCATCATTCATTCCTTCCTGTCAGCTAAGATTACA
AGACTGGGCTTGGTGGCCTGAAGACAGGGGTGACTTGCCTTTGAGAAAAGAAGGGCTGCAATGCCACCAGAGAACGTGATGTCAGACACC
ATCTGTAGTGAGCAGCGCACCAGATGTAGCGTGCTACAGTCAGCTTTAGCTCTCAAGAGTCGTATGTAACTGTCCCAGACTCCTCTGTCA
GTTTCAGCAACTACAAGGGATACCCTGCGAAAGTACCATGAGAAATATCAGAGTAAAACTTTCTAGAACAGTACAAGGTTAAAGAGGTGA
GGTGACGGGAAATACACAGCATAGCTTTGAAATAATGACAACCAAGGACATGACCATTAGAACAGCATGTGCAGATCTTAATCATCCCAG

>60531_60531_2_NSMCE2-SNTB1_NSMCE2_chr8_126163519_ENST00000287437_SNTB1_chr8_121587465_ENST00000517992_length(amino acids)=326AA_BP=120
MEEGNLSPKTEDTYLPHILSPAVFGGPGTNFKMPGRSSSNSGSTGFISFSGVESALSSLKNFQACINSGMDTASSVALDLVESQTEVSSE
YSMDKAMVEFATLDRQLNHYVKAVQSTINHVPGESKKQWKPALVVLTEKDLLIYDSMPRRKEAWFSPVHTYPLLATRLVHSGPGKGSPQA
GVDLSFATRTGTRQGIETHLFRAETSRDLSHWTRSIVQGCHNSAELIAEISTACTYKNQECRLTIHYENGFSITTEPQEGAFPKTIIQSP

--------------------------------------------------------------
>60531_60531_3_NSMCE2-SNTB1_NSMCE2_chr8_126163519_ENST00000517315_SNTB1_chr8_121587465_ENST00000395601_length(transcript)=4036nt_BP=283nt
TAATATGTGGTCTTTTGTGACTGGCTGTTTTCTTAGCATAAGGTTTTCAAGGTTCATCCATGTTGCATGTATCAGTGAGAGAGGTGGATG
CTTTGGAGCTTTTGGCTCAGAAATGATAATGTACATAACACAGGCAGCCATGAGTTAAAATGCAAGTTCTGCTATCTGCTAGCTCTCTGA
AGTGAGTAGTGAATATAGTATGGACAAGGCAATGGTTGAATTTGCTACATTGGATCGGCAACTAAACCATTATGTAAAGGCTGTTCAATC
TACAATAAATCATGTGCCAGGGGAGAGCAAGAAACAGTGGAAACCAGCCCTGGTTGTGCTGACTGAGAAAGACCTTTTAATCTATGACAG
CATGCCACGGAGGAAGGAAGCCTGGTTCAGCCCAGTTCACACATACCCTCTTCTTGCCACCAGGCTGGTCCATTCAGGTCCAGGAAAGGG
ATCACCCCAGGCTGGTGTGGATCTGTCCTTTGCAACGCGAACTGGTACCAGGCAAGGGATTGAAACACATCTCTTCAGAGCAGAGACCAG
CAGGGACCTCTCCCACTGGACAAGGAGCATAGTACAGGGTTGCCACAATTCTGCTGAACTCATTGCTGAAATCAGCACTGCTTGCACCTA
CAAAAACCAGGAGTGCCGTTTGACCATACATTATGAGAATGGATTTTCTATTACCACTGAACCACAGGAGGGTGCCTTTCCCAAGACCAT
CATACAGTCTCCTTATGAAAAGCTCAAAATGTCTTCAGATGATGGAATCAGGATGCTGTATTTAGATTTTGGAGGCAAAGATGGAGAGAT
TCAACTGGACCTTCATTCCTGCCCCAAGCCAATTGTTTTCATCATTCATTCCTTCCTGTCAGCTAAGATTACAAGACTGGGCTTGGTGGC
CTGAAGACAGGGGTGACTTGCCTTTGAGAAAAGAAGGGCTGCAATGCCACCAGAGAACGTGATGTCAGACACCATCTGTAGTGAGCAGCG
CACCAGATGTAGCGTGCTACAGTCAGCTTTAGCTCTCAAGAGTCGTATGTAACTGTCCCAGACTCCTCTGTCAGTTTCAGCAACTACAAG
GGATACCCTGCGAAAGTACCATGAGAAATATCAGAGTAAAACTTTCTAGAACAGTACAAGGTTAAAGAGGTGAGGTGACGGGAAATACAC
AGCATAGCTTTGAAATAATGACAACCAAGGACATGACCATTAGAACAGCATGTGCAGATCTTAATCATCCCAGTTCCTAGGCAACTTGTT
CACCAGGTACGCAAGGGCCGAATAGTTGAGAAATGGACATTCTTACCTACTCCTCCTAGCCCCCTATCCCCAGTAACAGTGATCCCTTTT
CTTATTGTGATTTATTTCCTAATTCTTGCTGAGTTGACTTTCCCTTGTAGGAAAAGAAAAATATTTCAAATAGAAACCCACCTTTTATTT
AAGTATGAAGCAGCTGTTACTTTTTAAAAAATGAATTATCTTTCAATGGTGTAGAATGATTCCAAAGTGTCTCCATTAGCATATACTGAG
CAGGAATTAAATAAAGCATCAGATACTGATCTGAGCTGTAAGCTGGTAGAATCTGAGCCAAAGTAGACTGCTTAAATTGATAAGCTTTGC
TAAAGAGTTGTATGCACAAAGGATGATTAATTCTGGGACTATACTCACACCAAGGTCTGCTGTCTTATAGCCAAGAATTACAGCTTTATT
TATAGAGAGTGAATTATGGGTATTTTTTCAGAAAATATTGTCATCTGATATACACATAAAACAACTCACATTGTTGGAGTTAACTAATTA
TCCCCATTTCATGGTTTTCAGTGGCAACTTACTGACCCTTGTTTTTGCCTGTGCTTGTATGCATGCATTTTCAAGCAAGTAATAAAGCAG
CCTCATTTAATTCTGGATAATGCTGGGTTTTACATATAGACTGAATGCTATAATCAAATCTATTGACAGTATCTGCAGTTCTTTCAGAAT
TCCAGGGAAATAATATAACGACCTGATATCTTTCTACAGGAATATTTTCAGACATTATATAGCACATTACTGATTTAATGCTTTTACTTT
TATCTTTCAAAACAAATTCACTAAAAATAACACCTATTGATTTTGAAGTCACTTTTCTCAAACCTTGAAAATGAGCTCTAGGATCTCTAT
AAACATTTCTAACACTTTTCCTGTAGTTTACATAGACAGACATCTGTTGTTAGACCTGTGTGTTTTTAAAGAATCATATGTTAACAAATA
CCCATGCAAAGAGCTTCAAAAAGTGAAACCGTGTTAAAGGAACACAATTTTTCTCACTCAGACATATTTGTTTATTGAATTGCAAAGTTT
TATTTTAAATCAGCATTTCCCCAAAGAATATATCATATGACGCTAGTTCCAAGGGGCTTGACTGAGTGGTGTTTTGCTGGGGGGAGACAG
GGGTTTGTTAATACACTTTACTAAATACTGAGCTGAAAAATGTTAAATAGATTTCACGATTGCCTCCTTGAAGATTTTAAAGTTCATTGT
GGTTCTTCAAGGCGAAATCCGGTGAACCATTCCTCACACTTACCTACAGGACTCTTTTCTAATGGAGCATCTTGTGAAGCTAGTGGGTTT
TTTTGTTGTTGTTATTTGTTTTTTTTTTTTAATGCTTTAGAAAACACAGCTTTAGGATATTGACTTTTTGTTTATTTCTATTTTCAAATG
CTGAAAAGTCAAGTCCCAGTTTGAATACCATAGAAAAGCTTTGATGCATTTGTAAATTATATTGCACTCTTTCACTATATATTTTCAAAA
TCACTGGAATGTTGTTATACAAGAGAATTATAATTGTGTATTGTAAATAACATATTAAAATACATATATTAATGCCAATAGTTAAATTCA
ACAATATGTAATCTAAGGTGCTCGGTTCTACATGAAGTATGAGTTAACTGCTCATAATTAAGTTGCCAAGATTCTATTATATATTTATAG
ACAAATTAAAATGATCATAATTACAAATATGATTTCTTTATCACTTAAGCTTTGGGCTGATTAATATCTGTGTGGGGGTCAATGGAAACT
ACATTCTCTACATTTATAAACATTTAATTTAATTATTTATATTTTAGGAAAATATATTTGAATAAAATTAATGCATTTTCTAGAGTAAAT
TAAAATGTTATTAGCAAGAAATAGAAAATTTGACTAAGATAATTGTGTATATGAATCATTTTTCCCCCAAGTTAAAATGTATCATAATAG
AGAGGCTCTAATGAATCAATTTCCAATACTCATTTCTTTCTTATTTTGAATTCAAGTTACAATGACTTTACACTGTAGATTTTAATCTTG
TCTGATGTGTGCTGGTGTGTATGACACAAACTCATAAGTCTGGATCATGCTTGGGTACAGTCAATGAATCAACCGAGTCACTTTGAGGAA
TTTGTTTTTGTCCAATTTGCTCTGTGCTCAATCCCATGAATTATTAAATTTACAATGTTTGTCCCCAAATGAAAACCAATATAAATGAAT
GATGTTTTAATCTGTACTTTATGGGAAGTTGCCTATTTGTCAGTAGATGTGGTTAAGTGAGTCCTCTGGTGCAGTGACATCCTTTTAAGC
CATCTCATAGGGATTTAAAGAAGGCCAATAGGAATATAGATATTGGTTTTTCTTTCTCTGACTTGAACTAAGTAGGAGAAACCAAACCAT
AAACCTATTACAAACTACCCAGGCAGAGGCATTTACTTAATTCATCAACTAGTGCAATTAAAACCCTGAAAACACATGATCCTTGTTGAC
TCTGCTTGGTTGAAGCAGGAAAGAATGGTCTTGATGGTCAGAAAGTTTTAAAATTAATGGGCAGGGCCTTTCTGGACCCTGTTTTCCAAA
CACGTTAGATATTCCGTCTTGAGGGGATTGGAGTAGGCTACAGTGAGGGGGTAATTTTTGGATGTATCTGGACTTTTAAAAAATGTGCCT

>60531_60531_3_NSMCE2-SNTB1_NSMCE2_chr8_126163519_ENST00000517315_SNTB1_chr8_121587465_ENST00000395601_length(amino acids)=234AA_BP=28
MDKAMVEFATLDRQLNHYVKAVQSTINHVPGESKKQWKPALVVLTEKDLLIYDSMPRRKEAWFSPVHTYPLLATRLVHSGPGKGSPQAGV
DLSFATRTGTRQGIETHLFRAETSRDLSHWTRSIVQGCHNSAELIAEISTACTYKNQECRLTIHYENGFSITTEPQEGAFPKTIIQSPYE

--------------------------------------------------------------
>60531_60531_4_NSMCE2-SNTB1_NSMCE2_chr8_126163519_ENST00000517315_SNTB1_chr8_121587465_ENST00000517992_length(transcript)=1260nt_BP=283nt
TAATATGTGGTCTTTTGTGACTGGCTGTTTTCTTAGCATAAGGTTTTCAAGGTTCATCCATGTTGCATGTATCAGTGAGAGAGGTGGATG
CTTTGGAGCTTTTGGCTCAGAAATGATAATGTACATAACACAGGCAGCCATGAGTTAAAATGCAAGTTCTGCTATCTGCTAGCTCTCTGA
AGTGAGTAGTGAATATAGTATGGACAAGGCAATGGTTGAATTTGCTACATTGGATCGGCAACTAAACCATTATGTAAAGGCTGTTCAATC
TACAATAAATCATGTGCCAGGGGAGAGCAAGAAACAGTGGAAACCAGCCCTGGTTGTGCTGACTGAGAAAGACCTTTTAATCTATGACAG
CATGCCACGGAGGAAGGAAGCCTGGTTCAGCCCAGTTCACACATACCCTCTTCTTGCCACCAGGCTGGTCCATTCAGGTCCAGGAAAGGG
ATCACCCCAGGCTGGTGTGGATCTGTCCTTTGCAACGCGAACTGGTACCAGGCAAGGGATTGAAACACATCTCTTCAGAGCAGAGACCAG
CAGGGACCTCTCCCACTGGACAAGGAGCATAGTACAGGGTTGCCACAATTCTGCTGAACTCATTGCTGAAATCAGCACTGCTTGCACCTA
CAAAAACCAGGAGTGCCGTTTGACCATACATTATGAGAATGGATTTTCTATTACCACTGAACCACAGGAGGGTGCCTTTCCCAAGACCAT
CATACAGTCTCCTTATGAAAAGCTCAAAATGTCTTCAGATGATGGAATCAGGATGCTGTATTTAGATTTTGGAGGCAAAGATGGAGAGAT
TCAACTGGACCTTCATTCCTGCCCCAAGCCAATTGTTTTCATCATTCATTCCTTCCTGTCAGCTAAGATTACAAGACTGGGCTTGGTGGC
CTGAAGACAGGGGTGACTTGCCTTTGAGAAAAGAAGGGCTGCAATGCCACCAGAGAACGTGATGTCAGACACCATCTGTAGTGAGCAGCG
CACCAGATGTAGCGTGCTACAGTCAGCTTTAGCTCTCAAGAGTCGTATGTAACTGTCCCAGACTCCTCTGTCAGTTTCAGCAACTACAAG
GGATACCCTGCGAAAGTACCATGAGAAATATCAGAGTAAAACTTTCTAGAACAGTACAAGGTTAAAGAGGTGAGGTGACGGGAAATACAC
AGCATAGCTTTGAAATAATGACAACCAAGGACATGACCATTAGAACAGCATGTGCAGATCTTAATCATCCCAGTTCCTAGGCAACTTGTT

>60531_60531_4_NSMCE2-SNTB1_NSMCE2_chr8_126163519_ENST00000517315_SNTB1_chr8_121587465_ENST00000517992_length(amino acids)=234AA_BP=28
MDKAMVEFATLDRQLNHYVKAVQSTINHVPGESKKQWKPALVVLTEKDLLIYDSMPRRKEAWFSPVHTYPLLATRLVHSGPGKGSPQAGV
DLSFATRTGTRQGIETHLFRAETSRDLSHWTRSIVQGCHNSAELIAEISTACTYKNQECRLTIHYENGFSITTEPQEGAFPKTIIQSPYE

--------------------------------------------------------------
>60531_60531_5_NSMCE2-SNTB1_NSMCE2_chr8_126163519_ENST00000522563_SNTB1_chr8_121587465_ENST00000395601_length(transcript)=4120nt_BP=367nt
AGCGGCAGGCGAAGGGGGCTGAGGAAAGGAGGTGGGTCTAGGCAGGGGAAATTGGGGTGCCACCAGACGGAGACAGCTTGGACTACCAGG
TACTAATTTCAAGATGCCAGGACGTTCCAGTTCAAATTCAGGTTCAACTGGTTTCATCTCCTTCAGTGGTGTAGAGTCTGCTCTCTCCTC
CTTGAAAAACTTCCAAGCCTGTATCAACTCTGGTATGGACACAGCTTCTAGTGTTGCTTTGGATCTTGTGGAAAGTCAGACTGAAGTGAG
TAGTGAATATAGTATGGACAAGGCAATGGTTGAATTTGCTACATTGGATCGGCAACTAAACCATTATGTAAAGGCTGTTCAATCTACAAT
AAATCATGTGCCAGGGGAGAGCAAGAAACAGTGGAAACCAGCCCTGGTTGTGCTGACTGAGAAAGACCTTTTAATCTATGACAGCATGCC
ACGGAGGAAGGAAGCCTGGTTCAGCCCAGTTCACACATACCCTCTTCTTGCCACCAGGCTGGTCCATTCAGGTCCAGGAAAGGGATCACC
CCAGGCTGGTGTGGATCTGTCCTTTGCAACGCGAACTGGTACCAGGCAAGGGATTGAAACACATCTCTTCAGAGCAGAGACCAGCAGGGA
CCTCTCCCACTGGACAAGGAGCATAGTACAGGGTTGCCACAATTCTGCTGAACTCATTGCTGAAATCAGCACTGCTTGCACCTACAAAAA
CCAGGAGTGCCGTTTGACCATACATTATGAGAATGGATTTTCTATTACCACTGAACCACAGGAGGGTGCCTTTCCCAAGACCATCATACA
GTCTCCTTATGAAAAGCTCAAAATGTCTTCAGATGATGGAATCAGGATGCTGTATTTAGATTTTGGAGGCAAAGATGGAGAGATTCAACT
GGACCTTCATTCCTGCCCCAAGCCAATTGTTTTCATCATTCATTCCTTCCTGTCAGCTAAGATTACAAGACTGGGCTTGGTGGCCTGAAG
ACAGGGGTGACTTGCCTTTGAGAAAAGAAGGGCTGCAATGCCACCAGAGAACGTGATGTCAGACACCATCTGTAGTGAGCAGCGCACCAG
ATGTAGCGTGCTACAGTCAGCTTTAGCTCTCAAGAGTCGTATGTAACTGTCCCAGACTCCTCTGTCAGTTTCAGCAACTACAAGGGATAC
CCTGCGAAAGTACCATGAGAAATATCAGAGTAAAACTTTCTAGAACAGTACAAGGTTAAAGAGGTGAGGTGACGGGAAATACACAGCATA
GCTTTGAAATAATGACAACCAAGGACATGACCATTAGAACAGCATGTGCAGATCTTAATCATCCCAGTTCCTAGGCAACTTGTTCACCAG
GTACGCAAGGGCCGAATAGTTGAGAAATGGACATTCTTACCTACTCCTCCTAGCCCCCTATCCCCAGTAACAGTGATCCCTTTTCTTATT
GTGATTTATTTCCTAATTCTTGCTGAGTTGACTTTCCCTTGTAGGAAAAGAAAAATATTTCAAATAGAAACCCACCTTTTATTTAAGTAT
GAAGCAGCTGTTACTTTTTAAAAAATGAATTATCTTTCAATGGTGTAGAATGATTCCAAAGTGTCTCCATTAGCATATACTGAGCAGGAA
TTAAATAAAGCATCAGATACTGATCTGAGCTGTAAGCTGGTAGAATCTGAGCCAAAGTAGACTGCTTAAATTGATAAGCTTTGCTAAAGA
GTTGTATGCACAAAGGATGATTAATTCTGGGACTATACTCACACCAAGGTCTGCTGTCTTATAGCCAAGAATTACAGCTTTATTTATAGA
GAGTGAATTATGGGTATTTTTTCAGAAAATATTGTCATCTGATATACACATAAAACAACTCACATTGTTGGAGTTAACTAATTATCCCCA
TTTCATGGTTTTCAGTGGCAACTTACTGACCCTTGTTTTTGCCTGTGCTTGTATGCATGCATTTTCAAGCAAGTAATAAAGCAGCCTCAT
TTAATTCTGGATAATGCTGGGTTTTACATATAGACTGAATGCTATAATCAAATCTATTGACAGTATCTGCAGTTCTTTCAGAATTCCAGG
GAAATAATATAACGACCTGATATCTTTCTACAGGAATATTTTCAGACATTATATAGCACATTACTGATTTAATGCTTTTACTTTTATCTT
TCAAAACAAATTCACTAAAAATAACACCTATTGATTTTGAAGTCACTTTTCTCAAACCTTGAAAATGAGCTCTAGGATCTCTATAAACAT
TTCTAACACTTTTCCTGTAGTTTACATAGACAGACATCTGTTGTTAGACCTGTGTGTTTTTAAAGAATCATATGTTAACAAATACCCATG
CAAAGAGCTTCAAAAAGTGAAACCGTGTTAAAGGAACACAATTTTTCTCACTCAGACATATTTGTTTATTGAATTGCAAAGTTTTATTTT
AAATCAGCATTTCCCCAAAGAATATATCATATGACGCTAGTTCCAAGGGGCTTGACTGAGTGGTGTTTTGCTGGGGGGAGACAGGGGTTT
GTTAATACACTTTACTAAATACTGAGCTGAAAAATGTTAAATAGATTTCACGATTGCCTCCTTGAAGATTTTAAAGTTCATTGTGGTTCT
TCAAGGCGAAATCCGGTGAACCATTCCTCACACTTACCTACAGGACTCTTTTCTAATGGAGCATCTTGTGAAGCTAGTGGGTTTTTTTGT
TGTTGTTATTTGTTTTTTTTTTTTAATGCTTTAGAAAACACAGCTTTAGGATATTGACTTTTTGTTTATTTCTATTTTCAAATGCTGAAA
AGTCAAGTCCCAGTTTGAATACCATAGAAAAGCTTTGATGCATTTGTAAATTATATTGCACTCTTTCACTATATATTTTCAAAATCACTG
GAATGTTGTTATACAAGAGAATTATAATTGTGTATTGTAAATAACATATTAAAATACATATATTAATGCCAATAGTTAAATTCAACAATA
TGTAATCTAAGGTGCTCGGTTCTACATGAAGTATGAGTTAACTGCTCATAATTAAGTTGCCAAGATTCTATTATATATTTATAGACAAAT
TAAAATGATCATAATTACAAATATGATTTCTTTATCACTTAAGCTTTGGGCTGATTAATATCTGTGTGGGGGTCAATGGAAACTACATTC
TCTACATTTATAAACATTTAATTTAATTATTTATATTTTAGGAAAATATATTTGAATAAAATTAATGCATTTTCTAGAGTAAATTAAAAT
GTTATTAGCAAGAAATAGAAAATTTGACTAAGATAATTGTGTATATGAATCATTTTTCCCCCAAGTTAAAATGTATCATAATAGAGAGGC
TCTAATGAATCAATTTCCAATACTCATTTCTTTCTTATTTTGAATTCAAGTTACAATGACTTTACACTGTAGATTTTAATCTTGTCTGAT
GTGTGCTGGTGTGTATGACACAAACTCATAAGTCTGGATCATGCTTGGGTACAGTCAATGAATCAACCGAGTCACTTTGAGGAATTTGTT
TTTGTCCAATTTGCTCTGTGCTCAATCCCATGAATTATTAAATTTACAATGTTTGTCCCCAAATGAAAACCAATATAAATGAATGATGTT
TTAATCTGTACTTTATGGGAAGTTGCCTATTTGTCAGTAGATGTGGTTAAGTGAGTCCTCTGGTGCAGTGACATCCTTTTAAGCCATCTC
ATAGGGATTTAAAGAAGGCCAATAGGAATATAGATATTGGTTTTTCTTTCTCTGACTTGAACTAAGTAGGAGAAACCAAACCATAAACCT
ATTACAAACTACCCAGGCAGAGGCATTTACTTAATTCATCAACTAGTGCAATTAAAACCCTGAAAACACATGATCCTTGTTGACTCTGCT
TGGTTGAAGCAGGAAAGAATGGTCTTGATGGTCAGAAAGTTTTAAAATTAATGGGCAGGGCCTTTCTGGACCCTGTTTTCCAAACACGTT
AGATATTCCGTCTTGAGGGGATTGGAGTAGGCTACAGTGAGGGGGTAATTTTTGGATGTATCTGGACTTTTAAAAAATGTGCCTATATTT

>60531_60531_5_NSMCE2-SNTB1_NSMCE2_chr8_126163519_ENST00000522563_SNTB1_chr8_121587465_ENST00000395601_length(amino acids)=294AA_BP=88
MPGRSSSNSGSTGFISFSGVESALSSLKNFQACINSGMDTASSVALDLVESQTEVSSEYSMDKAMVEFATLDRQLNHYVKAVQSTINHVP
GESKKQWKPALVVLTEKDLLIYDSMPRRKEAWFSPVHTYPLLATRLVHSGPGKGSPQAGVDLSFATRTGTRQGIETHLFRAETSRDLSHW
TRSIVQGCHNSAELIAEISTACTYKNQECRLTIHYENGFSITTEPQEGAFPKTIIQSPYEKLKMSSDDGIRMLYLDFGGKDGEIQLDLHS

--------------------------------------------------------------
>60531_60531_6_NSMCE2-SNTB1_NSMCE2_chr8_126163519_ENST00000522563_SNTB1_chr8_121587465_ENST00000517992_length(transcript)=1344nt_BP=367nt
AGCGGCAGGCGAAGGGGGCTGAGGAAAGGAGGTGGGTCTAGGCAGGGGAAATTGGGGTGCCACCAGACGGAGACAGCTTGGACTACCAGG
TACTAATTTCAAGATGCCAGGACGTTCCAGTTCAAATTCAGGTTCAACTGGTTTCATCTCCTTCAGTGGTGTAGAGTCTGCTCTCTCCTC
CTTGAAAAACTTCCAAGCCTGTATCAACTCTGGTATGGACACAGCTTCTAGTGTTGCTTTGGATCTTGTGGAAAGTCAGACTGAAGTGAG
TAGTGAATATAGTATGGACAAGGCAATGGTTGAATTTGCTACATTGGATCGGCAACTAAACCATTATGTAAAGGCTGTTCAATCTACAAT
AAATCATGTGCCAGGGGAGAGCAAGAAACAGTGGAAACCAGCCCTGGTTGTGCTGACTGAGAAAGACCTTTTAATCTATGACAGCATGCC
ACGGAGGAAGGAAGCCTGGTTCAGCCCAGTTCACACATACCCTCTTCTTGCCACCAGGCTGGTCCATTCAGGTCCAGGAAAGGGATCACC
CCAGGCTGGTGTGGATCTGTCCTTTGCAACGCGAACTGGTACCAGGCAAGGGATTGAAACACATCTCTTCAGAGCAGAGACCAGCAGGGA
CCTCTCCCACTGGACAAGGAGCATAGTACAGGGTTGCCACAATTCTGCTGAACTCATTGCTGAAATCAGCACTGCTTGCACCTACAAAAA
CCAGGAGTGCCGTTTGACCATACATTATGAGAATGGATTTTCTATTACCACTGAACCACAGGAGGGTGCCTTTCCCAAGACCATCATACA
GTCTCCTTATGAAAAGCTCAAAATGTCTTCAGATGATGGAATCAGGATGCTGTATTTAGATTTTGGAGGCAAAGATGGAGAGATTCAACT
GGACCTTCATTCCTGCCCCAAGCCAATTGTTTTCATCATTCATTCCTTCCTGTCAGCTAAGATTACAAGACTGGGCTTGGTGGCCTGAAG
ACAGGGGTGACTTGCCTTTGAGAAAAGAAGGGCTGCAATGCCACCAGAGAACGTGATGTCAGACACCATCTGTAGTGAGCAGCGCACCAG
ATGTAGCGTGCTACAGTCAGCTTTAGCTCTCAAGAGTCGTATGTAACTGTCCCAGACTCCTCTGTCAGTTTCAGCAACTACAAGGGATAC
CCTGCGAAAGTACCATGAGAAATATCAGAGTAAAACTTTCTAGAACAGTACAAGGTTAAAGAGGTGAGGTGACGGGAAATACACAGCATA

>60531_60531_6_NSMCE2-SNTB1_NSMCE2_chr8_126163519_ENST00000522563_SNTB1_chr8_121587465_ENST00000517992_length(amino acids)=294AA_BP=88
MPGRSSSNSGSTGFISFSGVESALSSLKNFQACINSGMDTASSVALDLVESQTEVSSEYSMDKAMVEFATLDRQLNHYVKAVQSTINHVP
GESKKQWKPALVVLTEKDLLIYDSMPRRKEAWFSPVHTYPLLATRLVHSGPGKGSPQAGVDLSFATRTGTRQGIETHLFRAETSRDLSHW
TRSIVQGCHNSAELIAEISTACTYKNQECRLTIHYENGFSITTEPQEGAFPKTIIQSPYEKLKMSSDDGIRMLYLDFGGKDGEIQLDLHS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NSMCE2-SNTB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NSMCE2-SNTB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NSMCE2-SNTB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource