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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGAP28-PSPN (FusionGDB2 ID:6054)

Fusion Gene Summary for ARHGAP28-PSPN

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP28-PSPN
Fusion gene ID: 6054
HgeneTgene
Gene symbol

ARHGAP28

PSPN

Gene ID

79822

5623

Gene nameRho GTPase activating protein 28persephin
Synonyms-PSP
Cytomap

18p11.31

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 28rho-type GTPase-activating protein 28persephin
Modification date2020031320200313
UniProtAcc

Q9P2N2

.
Ensembl transtripts involved in fusion geneENST00000314319, ENST00000383472, 
ENST00000419673, ENST00000531294, 
ENST00000262227, ENST00000400091, 
ENST00000418986, ENST00000532996, 
ENST00000245810, ENST00000597721, 
Fusion gene scores* DoF score3 X 3 X 3=272 X 2 X 2=8
# samples 32
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context

PubMed: ARHGAP28 [Title/Abstract] AND PSPN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP28(6909023)-PSPN(6375627), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARHGAP28 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PSPN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A15M-01AARHGAP28chr18

6909023

+PSPNchr19

6375627

-


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Fusion Gene ORF analysis for ARHGAP28-PSPN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000314319ENST00000245810ARHGAP28chr18

6909023

+PSPNchr19

6375627

-
Frame-shiftENST00000383472ENST00000245810ARHGAP28chr18

6909023

+PSPNchr19

6375627

-
Frame-shiftENST00000419673ENST00000245810ARHGAP28chr18

6909023

+PSPNchr19

6375627

-
Frame-shiftENST00000531294ENST00000245810ARHGAP28chr18

6909023

+PSPNchr19

6375627

-
In-frameENST00000314319ENST00000597721ARHGAP28chr18

6909023

+PSPNchr19

6375627

-
In-frameENST00000383472ENST00000597721ARHGAP28chr18

6909023

+PSPNchr19

6375627

-
In-frameENST00000419673ENST00000597721ARHGAP28chr18

6909023

+PSPNchr19

6375627

-
In-frameENST00000531294ENST00000597721ARHGAP28chr18

6909023

+PSPNchr19

6375627

-
intron-3CDSENST00000262227ENST00000245810ARHGAP28chr18

6909023

+PSPNchr19

6375627

-
intron-3CDSENST00000262227ENST00000597721ARHGAP28chr18

6909023

+PSPNchr19

6375627

-
intron-3CDSENST00000400091ENST00000245810ARHGAP28chr18

6909023

+PSPNchr19

6375627

-
intron-3CDSENST00000400091ENST00000597721ARHGAP28chr18

6909023

+PSPNchr19

6375627

-
intron-3CDSENST00000418986ENST00000245810ARHGAP28chr18

6909023

+PSPNchr19

6375627

-
intron-3CDSENST00000418986ENST00000597721ARHGAP28chr18

6909023

+PSPNchr19

6375627

-
intron-3CDSENST00000532996ENST00000245810ARHGAP28chr18

6909023

+PSPNchr19

6375627

-
intron-3CDSENST00000532996ENST00000597721ARHGAP28chr18

6909023

+PSPNchr19

6375627

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000383472ARHGAP28chr186909023+ENST00000597721PSPNchr196375627-26682199502521823
ENST00000419673ARHGAP28chr186909023+ENST00000597721PSPNchr196375627-23041835882157689
ENST00000531294ARHGAP28chr186909023+ENST00000597721PSPNchr196375627-22841815832137684
ENST00000314319ARHGAP28chr186909023+ENST00000597721PSPNchr196375627-22431774272096689

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000383472ENST00000597721ARHGAP28chr186909023+PSPNchr196375627-0.0018327830.99816716
ENST00000419673ENST00000597721ARHGAP28chr186909023+PSPNchr196375627-0.0020363010.99796367
ENST00000531294ENST00000597721ARHGAP28chr186909023+PSPNchr196375627-0.0041051320.9958949
ENST00000314319ENST00000597721ARHGAP28chr186909023+PSPNchr196375627-0.0020248790.9979752

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Fusion Genomic Features for ARHGAP28-PSPN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARHGAP28-PSPN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:6909023/chr19:6375627)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP28

Q9P2N2

.
FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP28chr18:6909023chr19:6375627ENST00000383472+1718380_577698730.0DomainRho-GAP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP28chr18:6909023chr19:6375627ENST00000262227+117380_5770671.0DomainRho-GAP
HgeneARHGAP28chr18:6909023chr19:6375627ENST00000314319+1516380_577539571.0DomainRho-GAP
HgeneARHGAP28chr18:6909023chr19:6375627ENST00000419673+1617380_577539571.0DomainRho-GAP
HgeneARHGAP28chr18:6909023chr19:6375627ENST00000532996+115380_5770546.0DomainRho-GAP


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Fusion Gene Sequence for ARHGAP28-PSPN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6054_6054_1_ARHGAP28-PSPN_ARHGAP28_chr18_6909023_ENST00000314319_PSPN_chr19_6375627_ENST00000597721_length(transcript)=2243nt_BP=1774nt
ACAGAAGGAGAACTTGAAGCAGAATGGCTGCAAGATGTGGGTTTATCAACTCTGATCTCAGGTGATGAAGAGGAAGATGGCAAAGCCTTG
CTCTCCACATTGACTCGAACCCAAGCAGCTGCCGTGCAAAAGAGATACCATACCTATACCCAAACCATGAGGAAAAAGGATAAGCAATCT
ATCAGGGATGTCAGAGACATTTTTGGAGTCAGTGAATCTCCTCCTCGTGATACCTGTGGCAACCACACTAATCAGCTGGATGGCACCAAG
GAAGAAAGAGAGCTTCCAAGAGTTATCAAGACAAGTGGTTCCATGCCAGATGATGCTTCTCTCAACAGTACTACCCTGTCTGACGCATCC
CAGGATAAAGAAGGGAGTTTTGCGGTTCCCAGGAGTGACTCTGTGGCTATACTTGAGACCATTCCAGTTCTACCAGTTCATTCCAATGGA
TCACCGGAGCCTGGACAGCCAGTTCAGAATGCGATAAGTGATGATGATTTTCTGGAAAAGAACATTCCACCAGAGGCTGAAGAGCTGTCA
TTTGAAGTGTCTTATTCAGAAATGGTTACGGAGGCTCTAAAAAGAAATAAACTTAAGAAATCAGAGATTAAGAAAGAAGACTATGTTTTA
ACTAAATTTAATGTTCAGAAAACCAGATTTGGCTTAACTGAAGCAGGAGATCTGTCTGCTGAAGACATGAAGAAAATCCGCCATCTCTCT
CTGATTGAATTGACTGCCTTTTTTGATGCCTTTGGAATTCAACTGAAAAGGAACAAAACAGAGAAAGTAAAAGGACGAGACAATGGGATT
TTTGGAGTTCCACTTACAGTCCTCCTGGACGGTGACCGAAAGAAAGACCCTGGAGTGAAAGTTCCCCTGGTATTACAAAAATTTTTTGAG
AAAGTTGAGGAATCAGGTCTGGAATCTGAAGGAATTTTTCGACTTTCAGGATGTACTGCTAAAGTCAAGCAATACCGTGAAGAACTTGAT
GCCAAGTTTAATGCTGATAAATTTAAATGGGACAAAATGTGCCATAGAGAAGCTGCAGTAATGTTGAAAGCGTTTTTCAGAGAACTACCC
ACCTCTCTCTTCCCTGTGGAATATATACCTGCCTTCATCAGTCTAATGGAAAGAGGGCCTCACGTCAAAGTACAGTTTCAAGCCTTACAC
CTCATGGTCATGGCGCTGCCTGATGCCAACAGAGATGCAGCTCAGGCCCTCATGACATTCTTCAATAAAGTGATTGCCAATGAATCAAAA
AACCGAATGAGTCTGTGGAACATTTCTACAGTGATGGCACCAAACCTTTTCTTCAGTAGAAGCAAACACTCTGATTATGAAGAATTACTG
TTAGCAAACACTGCGGCCCACATCATCCGCCTAATGCTTAAGTACCAGAAGATTTTGTGGAAGGTTCCATCTTTCTTAATCACTCAAGTA
AGAAGAATGAATGAAGCCACGATGCTATTGAAGAAGCAGCTCCCAAGTGTCAGGAAGCTGCTCAGGAGGAAGACCCTCGAGCGGGAGACT
GCAAGCCCCAAGACTTCAAAGGTACTGCAAAAATCACCCTCGGCAAGACGAATGTCTGACGTGCCGGAAGGAGTCATACGGGTCCATGCT
CCACTTCTCTCCAAGGTGTCCATGGCCATTCAACTCAACAATCAAACCAAAGCCAAAGACATATTGGCAAAATTTCAATATGAAAACAGT
CATGGTTCATCAGAATGTATTAAGATTCAGAACCAAAGGTTATATGAAATTGGAGGAAATATAGGCACCCACCGCCCCCTTGCCCGCCTG
CGCCGAGCCCTGTCTGGTCCATGCCAGCTGTGGAGCCTGACCCTGTCCGTGGCAGAGCTAGGCCTGGGCTACGCCTCAGAGGAGAAGGTC
ATCTTCCGCTACTGCGCCGGCAGCTGCCCCCGTGGTGCCCGCACCCAGCATGGCCTGGCGCTGGCCCGGCTGCAGGGCCAGGGCCGAGCC
CACGGCGGGCCCTGCTGCCGGCCCACTCGCTACACCGACGTGGCCTTCCTCGATGACCGCCACCGCTGGCAGCGGCTGCCCCAGCTCTCG
GCGGCTGCCTGCGGCTGTGGTGGCTGAGGGTGCCCGGCCTGGCACCCAGAAGCTGCAGTGCTGGGGGAGCTCGGCTGACTTATTTATTGG

>6054_6054_1_ARHGAP28-PSPN_ARHGAP28_chr18_6909023_ENST00000314319_PSPN_chr19_6375627_ENST00000597721_length(amino acids)=689AA_BP=582
MQDVGLSTLISGDEEEDGKALLSTLTRTQAAAVQKRYHTYTQTMRKKDKQSIRDVRDIFGVSESPPRDTCGNHTNQLDGTKEERELPRVI
KTSGSMPDDASLNSTTLSDASQDKEGSFAVPRSDSVAILETIPVLPVHSNGSPEPGQPVQNAISDDDFLEKNIPPEAEELSFEVSYSEMV
TEALKRNKLKKSEIKKEDYVLTKFNVQKTRFGLTEAGDLSAEDMKKIRHLSLIELTAFFDAFGIQLKRNKTEKVKGRDNGIFGVPLTVLL
DGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYI
PAFISLMERGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSKHSDYEELLLANTAAHII
RLMLKYQKILWKVPSFLITQVRRMNEATMLLKKQLPSVRKLLRRKTLERETASPKTSKVLQKSPSARRMSDVPEGVIRVHAPLLSKVSMA
IQLNNQTKAKDILAKFQYENSHGSSECIKIQNQRLYEIGGNIGTHRPLARLRRALSGPCQLWSLTLSVAELGLGYASEEKVIFRYCAGSC

--------------------------------------------------------------
>6054_6054_2_ARHGAP28-PSPN_ARHGAP28_chr18_6909023_ENST00000383472_PSPN_chr19_6375627_ENST00000597721_length(transcript)=2668nt_BP=2199nt
ACCTCGGGCCGCGCCGCCCAGCTGCTGACAGCCTCCCGGCGCGCCGGTCCATGCTGGTCCCGGTCTTTGTTCTGGGGCCGGCGCCGAGAC
ATGCGCGGCTGACGATGGAGGTGGAGGACTCGGGCGGCGTGGTGCTGACCGCCTACCACTCGTACGCGCGCGCCCAGCCCCCCAACGCCG
AGTCGCGCTGCGCGCCCCGCGCCGCAGCCAGCCACCCGCTCAGCAGAAAATCCATTCCTCGCTGCCGAAGAATTAACAGGATGCTCTCCA
ATGAATCCCTCCATCCTCCTGCCTTCAGCCGTTCCAACTCAGAAGCCTCCGTAGACAGCGCCTCCATGGAGGATTTCTGGCGGGAAATAG
AAAGTATTAAAGACAGCAGCATGGGAGGGCAAGAAGAGCCACCGCCAGCTGAGGTCACACCTGTGGATGAAGGAGAACTTGAAGCAGAAT
GGCTGCAAGATGTGGGTTTATCAACTCTGATCTCAGGTGATGAAGAGGAAGATGGCAAAGCCTTGCTCTCCACATTGACTCGAACCCAAG
CAGCTGCCGTGCAAAAGAGATACCATACCTATACCCAAACCATGAGGAAAAAGGATAAGCAATCTATCAGGGATGTCAGAGACATTTTTG
GAGTCAGTGAATCTCCTCCTCGTGATACCTGTGGCAACCACACTAATCAGCTGGATGGCACCAAGGAAGAAAGAGAGCTTCCAAGAGTTA
TCAAGACAAGTGGTTCCATGCCAGATGATGCTTCTCTCAACAGTACTACCCTGTCTGACGCATCCCAGGATAAAGAAGGGAGTTTTGCGG
TTCCCAGGAGTGACTCTGTGGCTATACTTGAGACCATTCCAGTTCTACCAGTTCATTCCAATGGATCACCGGAGCCTGGACAGCCAGTTC
AGAATGCGATAAGTGATGATGATTTTCTGGAAAAGAACATTCCACCAGAGGCTGAAGAGCTGTCATTTGAAGTGTCTTATTCAGAAATGG
TTACGGAGGCTCTAAAAAGAAATAAACTTAAGAAATCAGAGATTAAGAAAGAAGACTATGTTTTAACTAAATTTAATGTTCAGAAAACCA
GATTTGGCTTAACTGAAGCAGGAGATCTGTCTGCTGAAGACATGAAGAAAATCCGCCATCTCTCTCTGATTGAATTGACTGCCTTTTTTG
ATGCCTTTGGAATTCAACTGAAAAGGAACAAAACAGAGAAAGTAAAAGGACGAGACAATGGGATTTTTGGAGTTCCACTTACAGTCCTCC
TGGACGGTGACCGAAAGAAAGACCCTGGAGTGAAAGTTCCCCTGGTATTACAAAAATTTTTTGAGAAAGTTGAGGAATCAGGTCTGGAAT
CTGAAGGAATTTTTCGACTTTCAGGATGTACTGCTAAAGTCAAGCAATACCGTGAAGAACTTGATGCCAAGTTTAATGCTGATAAATTTA
AATGGGACAAAATGTGCCATAGAGAAGCTGCAGTAATGTTGAAAGCGTTTTTCAGAGAACTACCCACCTCTCTCTTCCCTGTGGAATATA
TACCTGCCTTCATCAGTCTAATGGAAAGAGGGCCTCACGTCAAAGTACAGTTTCAAGCCTTACACCTCATGGTCATGGCGCTGCCTGATG
CCAACAGAGATGCAGCTCAGGCCCTCATGACATTCTTCAATAAAGTGATTGCCAATGAATCAAAAAACCGAATGAGTCTGTGGAACATTT
CTACAGTGATGGCACCAAACCTTTTCTTCAGTAGAAGCAAACACTCTGATTATGAAGAATTACTGTTAGCAAACACTGCGGCCCACATCA
TCCGCCTAATGCTTAAGTACCAGAAGATTTTGTGGAAGGTTCCATCTTTCTTAATCACTCAAGTAAGAAGAATGAATGAAGCCACGATGC
TATTGAAGAAGCAGCTCCCAAGTGTCAGGAAGCTGCTCAGGAGGAAGACCCTCGAGCGGGAGACTGCAAGCCCCAAGACTTCAAAGGTAC
TGCAAAAATCACCCTCGGCAAGACGAATGTCTGACGTGCCGGAAGGAGTCATACGGGTCCATGCTCCACTTCTCTCCAAGGTGTCCATGG
CCATTCAACTCAACAATCAAACCAAAGCCAAAGACATATTGGCAAAATTTCAATATGAAAACAGTCATGGTTCATCAGAATGTATTAAGA
TTCAGAACCAAAGGTTATATGAAATTGGAGGAAATATAGGCACCCACCGCCCCCTTGCCCGCCTGCGCCGAGCCCTGTCTGGTCCATGCC
AGCTGTGGAGCCTGACCCTGTCCGTGGCAGAGCTAGGCCTGGGCTACGCCTCAGAGGAGAAGGTCATCTTCCGCTACTGCGCCGGCAGCT
GCCCCCGTGGTGCCCGCACCCAGCATGGCCTGGCGCTGGCCCGGCTGCAGGGCCAGGGCCGAGCCCACGGCGGGCCCTGCTGCCGGCCCA
CTCGCTACACCGACGTGGCCTTCCTCGATGACCGCCACCGCTGGCAGCGGCTGCCCCAGCTCTCGGCGGCTGCCTGCGGCTGTGGTGGCT
GAGGGTGCCCGGCCTGGCACCCAGAAGCTGCAGTGCTGGGGGAGCTCGGCTGACTTATTTATTGGAGACCTGGATGCAGAGACAACGAGG

>6054_6054_2_ARHGAP28-PSPN_ARHGAP28_chr18_6909023_ENST00000383472_PSPN_chr19_6375627_ENST00000597721_length(amino acids)=823AA_BP=716
MLVPVFVLGPAPRHARLTMEVEDSGGVVLTAYHSYARAQPPNAESRCAPRAAASHPLSRKSIPRCRRINRMLSNESLHPPAFSRSNSEAS
VDSASMEDFWREIESIKDSSMGGQEEPPPAEVTPVDEGELEAEWLQDVGLSTLISGDEEEDGKALLSTLTRTQAAAVQKRYHTYTQTMRK
KDKQSIRDVRDIFGVSESPPRDTCGNHTNQLDGTKEERELPRVIKTSGSMPDDASLNSTTLSDASQDKEGSFAVPRSDSVAILETIPVLP
VHSNGSPEPGQPVQNAISDDDFLEKNIPPEAEELSFEVSYSEMVTEALKRNKLKKSEIKKEDYVLTKFNVQKTRFGLTEAGDLSAEDMKK
IRHLSLIELTAFFDAFGIQLKRNKTEKVKGRDNGIFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQY
REELDAKFNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAFISLMERGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVI
ANESKNRMSLWNISTVMAPNLFFSRSKHSDYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVRRMNEATMLLKKQLPSVRKLLRRKT
LERETASPKTSKVLQKSPSARRMSDVPEGVIRVHAPLLSKVSMAIQLNNQTKAKDILAKFQYENSHGSSECIKIQNQRLYEIGGNIGTHR
PLARLRRALSGPCQLWSLTLSVAELGLGYASEEKVIFRYCAGSCPRGARTQHGLALARLQGQGRAHGGPCCRPTRYTDVAFLDDRHRWQR

--------------------------------------------------------------
>6054_6054_3_ARHGAP28-PSPN_ARHGAP28_chr18_6909023_ENST00000419673_PSPN_chr19_6375627_ENST00000597721_length(transcript)=2304nt_BP=1835nt
AAAGTAGGCCAGTATTGCCAGAGAACAGGAGAGGAGGAGAGTATGGTATAAGCATGTCCAGAAATAAGGAGAACTTGAAGCAGAATGGCT
GCAAGATGTGGGTTTATCAACTCTGATCTCAGGTGATGAAGAGGAAGATGGCAAAGCCTTGCTCTCCACATTGACTCGAACCCAAGCAGC
TGCCGTGCAAAAGAGATACCATACCTATACCCAAACCATGAGGAAAAAGGATAAGCAATCTATCAGGGATGTCAGAGACATTTTTGGAGT
CAGTGAATCTCCTCCTCGTGATACCTGTGGCAACCACACTAATCAGCTGGATGGCACCAAGGAAGAAAGAGAGCTTCCAAGAGTTATCAA
GACAAGTGGTTCCATGCCAGATGATGCTTCTCTCAACAGTACTACCCTGTCTGACGCATCCCAGGATAAAGAAGGGAGTTTTGCGGTTCC
CAGGAGTGACTCTGTGGCTATACTTGAGACCATTCCAGTTCTACCAGTTCATTCCAATGGATCACCGGAGCCTGGACAGCCAGTTCAGAA
TGCGATAAGTGATGATGATTTTCTGGAAAAGAACATTCCACCAGAGGCTGAAGAGCTGTCATTTGAAGTGTCTTATTCAGAAATGGTTAC
GGAGGCTCTAAAAAGAAATAAACTTAAGAAATCAGAGATTAAGAAAGAAGACTATGTTTTAACTAAATTTAATGTTCAGAAAACCAGATT
TGGCTTAACTGAAGCAGGAGATCTGTCTGCTGAAGACATGAAGAAAATCCGCCATCTCTCTCTGATTGAATTGACTGCCTTTTTTGATGC
CTTTGGAATTCAACTGAAAAGGAACAAAACAGAGAAAGTAAAAGGACGAGACAATGGGATTTTTGGAGTTCCACTTACAGTCCTCCTGGA
CGGTGACCGAAAGAAAGACCCTGGAGTGAAAGTTCCCCTGGTATTACAAAAATTTTTTGAGAAAGTTGAGGAATCAGGTCTGGAATCTGA
AGGAATTTTTCGACTTTCAGGATGTACTGCTAAAGTCAAGCAATACCGTGAAGAACTTGATGCCAAGTTTAATGCTGATAAATTTAAATG
GGACAAAATGTGCCATAGAGAAGCTGCAGTAATGTTGAAAGCGTTTTTCAGAGAACTACCCACCTCTCTCTTCCCTGTGGAATATATACC
TGCCTTCATCAGTCTAATGGAAAGAGGGCCTCACGTCAAAGTACAGTTTCAAGCCTTACACCTCATGGTCATGGCGCTGCCTGATGCCAA
CAGAGATGCAGCTCAGGCCCTCATGACATTCTTCAATAAAGTGATTGCCAATGAATCAAAAAACCGAATGAGTCTGTGGAACATTTCTAC
AGTGATGGCACCAAACCTTTTCTTCAGTAGAAGCAAACACTCTGATTATGAAGAATTACTGTTAGCAAACACTGCGGCCCACATCATCCG
CCTAATGCTTAAGTACCAGAAGATTTTGTGGAAGGTTCCATCTTTCTTAATCACTCAAGTAAGAAGAATGAATGAAGCCACGATGCTATT
GAAGAAGCAGCTCCCAAGTGTCAGGAAGCTGCTCAGGAGGAAGACCCTCGAGCGGGAGACTGCAAGCCCCAAGACTTCAAAGGTACTGCA
AAAATCACCCTCGGCAAGACGAATGTCTGACGTGCCGGAAGGAGTCATACGGGTCCATGCTCCACTTCTCTCCAAGGTGTCCATGGCCAT
TCAACTCAACAATCAAACCAAAGCCAAAGACATATTGGCAAAATTTCAATATGAAAACAGTCATGGTTCATCAGAATGTATTAAGATTCA
GAACCAAAGGTTATATGAAATTGGAGGAAATATAGGCACCCACCGCCCCCTTGCCCGCCTGCGCCGAGCCCTGTCTGGTCCATGCCAGCT
GTGGAGCCTGACCCTGTCCGTGGCAGAGCTAGGCCTGGGCTACGCCTCAGAGGAGAAGGTCATCTTCCGCTACTGCGCCGGCAGCTGCCC
CCGTGGTGCCCGCACCCAGCATGGCCTGGCGCTGGCCCGGCTGCAGGGCCAGGGCCGAGCCCACGGCGGGCCCTGCTGCCGGCCCACTCG
CTACACCGACGTGGCCTTCCTCGATGACCGCCACCGCTGGCAGCGGCTGCCCCAGCTCTCGGCGGCTGCCTGCGGCTGTGGTGGCTGAGG
GTGCCCGGCCTGGCACCCAGAAGCTGCAGTGCTGGGGGAGCTCGGCTGACTTATTTATTGGAGACCTGGATGCAGAGACAACGAGGAGGG

>6054_6054_3_ARHGAP28-PSPN_ARHGAP28_chr18_6909023_ENST00000419673_PSPN_chr19_6375627_ENST00000597721_length(amino acids)=689AA_BP=582
MQDVGLSTLISGDEEEDGKALLSTLTRTQAAAVQKRYHTYTQTMRKKDKQSIRDVRDIFGVSESPPRDTCGNHTNQLDGTKEERELPRVI
KTSGSMPDDASLNSTTLSDASQDKEGSFAVPRSDSVAILETIPVLPVHSNGSPEPGQPVQNAISDDDFLEKNIPPEAEELSFEVSYSEMV
TEALKRNKLKKSEIKKEDYVLTKFNVQKTRFGLTEAGDLSAEDMKKIRHLSLIELTAFFDAFGIQLKRNKTEKVKGRDNGIFGVPLTVLL
DGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYI
PAFISLMERGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSKHSDYEELLLANTAAHII
RLMLKYQKILWKVPSFLITQVRRMNEATMLLKKQLPSVRKLLRRKTLERETASPKTSKVLQKSPSARRMSDVPEGVIRVHAPLLSKVSMA
IQLNNQTKAKDILAKFQYENSHGSSECIKIQNQRLYEIGGNIGTHRPLARLRRALSGPCQLWSLTLSVAELGLGYASEEKVIFRYCAGSC

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>6054_6054_4_ARHGAP28-PSPN_ARHGAP28_chr18_6909023_ENST00000531294_PSPN_chr19_6375627_ENST00000597721_length(transcript)=2284nt_BP=1815nt
AGGCCAGTATTGCCAGAGAACAGGAGAGGAGGAGAGTATGGTATAAGCATGTCCAGAAATAAGGAGAACTTGAAGCAGAATGGCTGCAAG
ATGTGGGTTTATCAACTCTGATCTCAGGTGATGAAGAGGAAGATGGCAAAGCCTTGCTCTCCACATTGACTCGAACCCAAGCAGCTGCCG
TGCAAAAGAGATACCATACCTATACCCAAACCATGAGGAAAAAGGATAAGCAATCTATCAGGGATGTCAGAGACATTTTTGGAGTCAGTG
AATCTCCTCCTCGTGATACCTGTGGCAACCACACTAATCAGCTGGATGGCACCAAGGAAGAAAGAGAGCTTCCAAGAGTTATCAAGACAA
ATGATGCTTCTCTCAACAGTACTACCCTGTCTGACGCATCCCAGGATAAAGAAGGGAGTTTTGCGGTTCCCAGGAGTGACTCTGTGGCTA
TACTTGAGACCATTCCAGTTCTACCAGTTCATTCCAATGGATCACCGGAGCCTGGACAGCCAGTTCAGAATGCGATAAGTGATGATGATT
TTCTGGAAAAGAACATTCCACCAGAGGCTGAAGAGCTGTCATTTGAAGTGTCTTATTCAGAAATGGTTACGGAGGCTCTAAAAAGAAATA
AACTTAAGAAATCAGAGATTAAGAAAGAAGACTATGTTTTAACTAAATTTAATGTTCAGAAAACCAGATTTGGCTTAACTGAAGCAGGAG
ATCTGTCTGCTGAAGACATGAAGAAAATCCGCCATCTCTCTCTGATTGAATTGACTGCCTTTTTTGATGCCTTTGGAATTCAACTGAAAA
GGAACAAAACAGAGAAAGTAAAAGGACGAGACAATGGGATTTTTGGAGTTCCACTTACAGTCCTCCTGGACGGTGACCGAAAGAAAGACC
CTGGAGTGAAAGTTCCCCTGGTATTACAAAAATTTTTTGAGAAAGTTGAGGAATCAGGTCTGGAATCTGAAGGAATTTTTCGACTTTCAG
GATGTACTGCTAAAGTCAAGCAATACCGTGAAGAACTTGATGCCAAGTTTAATGCTGATAAATTTAAATGGGACAAAATGTGCCATAGAG
AAGCTGCAGTAATGTTGAAAGCGTTTTTCAGAGAACTACCCACCTCTCTCTTCCCTGTGGAATATATACCTGCCTTCATCAGTCTAATGG
AAAGAGGGCCTCACGTCAAAGTACAGTTTCAAGCCTTACACCTCATGGTCATGGCGCTGCCTGATGCCAACAGAGATGCAGCTCAGGCCC
TCATGACATTCTTCAATAAAGTGATTGCCAATGAATCAAAAAACCGAATGAGTCTGTGGAACATTTCTACAGTGATGGCACCAAACCTTT
TCTTCAGTAGAAGCAAACACTCTGATTATGAAGAATTACTGTTAGCAAACACTGCGGCCCACATCATCCGCCTAATGCTTAAGTACCAGA
AGATTTTGTGGAAGGTTCCATCTTTCTTAATCACTCAAGTAAGAAGAATGAATGAAGCCACGATGCTATTGAAGAAGCAGCTCCCAAGTG
TCAGGAAGCTGCTCAGGAGGAAGACCCTCGAGCGGGAGACTGCAAGCCCCAAGACTTCAAAGGTACTGCAAAAATCACCCTCGGCAAGAC
GAATGTCTGACGTGCCGGAAGGAGTCATACGGGTCCATGCTCCACTTCTCTCCAAGGTGTCCATGGCCATTCAACTCAACAATCAAACCA
AAGCCAAAGACATATTGGCAAAATTTCAATATGAAAACAGTCATGGTTCATCAGAATGTATTAAGATTCAGAACCAAAGGTTATATGAAA
TTGGAGGAAATATAGGCACCCACCGCCCCCTTGCCCGCCTGCGCCGAGCCCTGTCTGGTCCATGCCAGCTGTGGAGCCTGACCCTGTCCG
TGGCAGAGCTAGGCCTGGGCTACGCCTCAGAGGAGAAGGTCATCTTCCGCTACTGCGCCGGCAGCTGCCCCCGTGGTGCCCGCACCCAGC
ATGGCCTGGCGCTGGCCCGGCTGCAGGGCCAGGGCCGAGCCCACGGCGGGCCCTGCTGCCGGCCCACTCGCTACACCGACGTGGCCTTCC
TCGATGACCGCCACCGCTGGCAGCGGCTGCCCCAGCTCTCGGCGGCTGCCTGCGGCTGTGGTGGCTGAGGGTGCCCGGCCTGGCACCCAG
AAGCTGCAGTGCTGGGGGAGCTCGGCTGACTTATTTATTGGAGACCTGGATGCAGAGACAACGAGGAGGGGAGTGGGCTGGGGCGACCAG

>6054_6054_4_ARHGAP28-PSPN_ARHGAP28_chr18_6909023_ENST00000531294_PSPN_chr19_6375627_ENST00000597721_length(amino acids)=684AA_BP=577
MQDVGLSTLISGDEEEDGKALLSTLTRTQAAAVQKRYHTYTQTMRKKDKQSIRDVRDIFGVSESPPRDTCGNHTNQLDGTKEERELPRVI
KTNDASLNSTTLSDASQDKEGSFAVPRSDSVAILETIPVLPVHSNGSPEPGQPVQNAISDDDFLEKNIPPEAEELSFEVSYSEMVTEALK
RNKLKKSEIKKEDYVLTKFNVQKTRFGLTEAGDLSAEDMKKIRHLSLIELTAFFDAFGIQLKRNKTEKVKGRDNGIFGVPLTVLLDGDRK
KDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAFIS
LMERGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSKHSDYEELLLANTAAHIIRLMLK
YQKILWKVPSFLITQVRRMNEATMLLKKQLPSVRKLLRRKTLERETASPKTSKVLQKSPSARRMSDVPEGVIRVHAPLLSKVSMAIQLNN
QTKAKDILAKFQYENSHGSSECIKIQNQRLYEIGGNIGTHRPLARLRRALSGPCQLWSLTLSVAELGLGYASEEKVIFRYCAGSCPRGAR

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Fusion Gene PPI Analysis for ARHGAP28-PSPN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGAP28-PSPN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGAP28-PSPN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource