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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:NSMF-ZMYND19 (FusionGDB2 ID:60544)

Fusion Gene Summary for NSMF-ZMYND19

Fusion gene summary

Fusion gene information	Fusion gene name: NSMF-ZMYND19
	Fusion gene ID: 60544
		Hgene	Tgene
	Gene symbol	NSMF	ZMYND19
	Gene ID	26012	116225
	Gene name	NMDA receptor synaptonuclear signaling and neuronal migration factor	zinc finger MYND-type containing 19
	Synonyms	HH9\|NELF	MIZIP
	Cytomap	9q34.3	9q34.3
	Type of gene	protein-coding	protein-coding
	Description	NMDA receptor synaptonuclear signaling and neuronal migration factornasal embryonic LHRH factornasal embryonic luteinizing hormone-releasing hormone factor	zinc finger MYND domain-containing protein 19MCH-R1-interacting zinc finger proteinmelanin-concentrating hormone receptor 1 interacting zinc-finger proteinzinc finger, MYND domain containing 19
	Modification date	20200313	20200313
	UniProtAcc	Q6X4W1	.
	Ensembl transtripts involved in fusion gene	ENST00000265663, ENST00000339554, ENST00000371472, ENST00000371473, ENST00000371474, ENST00000371475, ENST00000371482, ENST00000392812, ENST00000437259, ENST00000541195, ENST00000484316, ENST00000371468,	ENST00000471957, ENST00000298585,
Fusion gene scores	* DoF score	2 X 2 X 2=8	5 X 4 X 7=140
	# samples	3	8
	** MAII score	log2(3/8*10)=1.90689059560852	log2(8/140*10)=-0.807354922057604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NSMF [Title/Abstract] AND ZMYND19 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NSMF(140346817)-ZMYND19(140477138), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across NSMF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ZMYND19 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-L5-A4OS-01A	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-
ChimerDB4	ESCA	TCGA-L5-A4OS	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-
ChimerDB4	ESCA	TCGA-L5-A4OS	NSMF	chr9	140346817	-	ZMYND19	chr9	140477505	-

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Fusion Gene ORF analysis for NSMF-ZMYND19

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000265663	ENST00000471957	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-
5CDS-intron	ENST00000265663	ENST00000471957	NSMF	chr9	140346817	-	ZMYND19	chr9	140477505	-
5CDS-intron	ENST00000339554	ENST00000471957	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-
5CDS-intron	ENST00000339554	ENST00000471957	NSMF	chr9	140346817	-	ZMYND19	chr9	140477505	-
5CDS-intron	ENST00000371472	ENST00000471957	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-
5CDS-intron	ENST00000371472	ENST00000471957	NSMF	chr9	140346817	-	ZMYND19	chr9	140477505	-
5CDS-intron	ENST00000371473	ENST00000471957	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-
5CDS-intron	ENST00000371473	ENST00000471957	NSMF	chr9	140346817	-	ZMYND19	chr9	140477505	-
5CDS-intron	ENST00000371474	ENST00000471957	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-
5CDS-intron	ENST00000371474	ENST00000471957	NSMF	chr9	140346817	-	ZMYND19	chr9	140477505	-
5CDS-intron	ENST00000371475	ENST00000471957	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-
5CDS-intron	ENST00000371475	ENST00000471957	NSMF	chr9	140346817	-	ZMYND19	chr9	140477505	-
5CDS-intron	ENST00000371482	ENST00000471957	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-
5CDS-intron	ENST00000371482	ENST00000471957	NSMF	chr9	140346817	-	ZMYND19	chr9	140477505	-
5CDS-intron	ENST00000392812	ENST00000471957	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-
5CDS-intron	ENST00000392812	ENST00000471957	NSMF	chr9	140346817	-	ZMYND19	chr9	140477505	-
5CDS-intron	ENST00000437259	ENST00000471957	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-
5CDS-intron	ENST00000437259	ENST00000471957	NSMF	chr9	140346817	-	ZMYND19	chr9	140477505	-
5CDS-intron	ENST00000541195	ENST00000471957	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-
5CDS-intron	ENST00000541195	ENST00000471957	NSMF	chr9	140346817	-	ZMYND19	chr9	140477505	-
5UTR-3CDS	ENST00000484316	ENST00000298585	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-
5UTR-3CDS	ENST00000484316	ENST00000298585	NSMF	chr9	140346817	-	ZMYND19	chr9	140477505	-
5UTR-intron	ENST00000484316	ENST00000471957	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-
5UTR-intron	ENST00000484316	ENST00000471957	NSMF	chr9	140346817	-	ZMYND19	chr9	140477505	-
Frame-shift	ENST00000265663	ENST00000298585	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-
Frame-shift	ENST00000265663	ENST00000298585	NSMF	chr9	140346817	-	ZMYND19	chr9	140477505	-
Frame-shift	ENST00000339554	ENST00000298585	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-
Frame-shift	ENST00000339554	ENST00000298585	NSMF	chr9	140346817	-	ZMYND19	chr9	140477505	-
Frame-shift	ENST00000371472	ENST00000298585	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-
Frame-shift	ENST00000371472	ENST00000298585	NSMF	chr9	140346817	-	ZMYND19	chr9	140477505	-
Frame-shift	ENST00000371473	ENST00000298585	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-
Frame-shift	ENST00000371473	ENST00000298585	NSMF	chr9	140346817	-	ZMYND19	chr9	140477505	-
Frame-shift	ENST00000371474	ENST00000298585	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-
Frame-shift	ENST00000371474	ENST00000298585	NSMF	chr9	140346817	-	ZMYND19	chr9	140477505	-
Frame-shift	ENST00000371475	ENST00000298585	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-
Frame-shift	ENST00000371475	ENST00000298585	NSMF	chr9	140346817	-	ZMYND19	chr9	140477505	-
Frame-shift	ENST00000392812	ENST00000298585	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-
Frame-shift	ENST00000392812	ENST00000298585	NSMF	chr9	140346817	-	ZMYND19	chr9	140477505	-
Frame-shift	ENST00000437259	ENST00000298585	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-
Frame-shift	ENST00000437259	ENST00000298585	NSMF	chr9	140346817	-	ZMYND19	chr9	140477505	-
Frame-shift	ENST00000541195	ENST00000298585	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-
Frame-shift	ENST00000541195	ENST00000298585	NSMF	chr9	140346817	-	ZMYND19	chr9	140477505	-
In-frame	ENST00000371482	ENST00000298585	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-
In-frame	ENST00000371482	ENST00000298585	NSMF	chr9	140346817	-	ZMYND19	chr9	140477505	-
intron-3CDS	ENST00000371468	ENST00000298585	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-
intron-3CDS	ENST00000371468	ENST00000298585	NSMF	chr9	140346817	-	ZMYND19	chr9	140477505	-
intron-intron	ENST00000371468	ENST00000471957	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-
intron-intron	ENST00000371468	ENST00000471957	NSMF	chr9	140346817	-	ZMYND19	chr9	140477505	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000371482	NSMF	chr9	140346817	-	ENST00000298585	ZMYND19	chr9	140477138	-	1970	1362	956	306	216
ENST00000371482	NSMF	chr9	140346817	-	ENST00000298585	ZMYND19	chr9	140477505	-	2041	1362	956	306	216

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000371482	ENST00000298585	NSMF	chr9	140346817	-	ZMYND19	chr9	140477138	-	0.8630661	0.13693386
ENST00000371482	ENST00000298585	NSMF	chr9	140346817	-	ZMYND19	chr9	140477505	-	0.8176367	0.18236321

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Fusion Genomic Features for NSMF-ZMYND19

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NSMF-ZMYND19

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:140346817/chr9:140477138)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NSMF Q6X4W1	.
FUNCTION: Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells. {ECO:0000269\|PubMed:20025934}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NSMF

chr9:140346817

chr9:140477138

ENST00000265663

2_233

410

529.0

Region

Necessary and sufficient to elicit dendritic processes and synaptic contacts

Hgene

NSMF

chr9:140346817

chr9:140477138

ENST00000371472

2_233

410

472.3333333333333

Region

Necessary and sufficient to elicit dendritic processes and synaptic contacts

Hgene

NSMF

chr9:140346817

chr9:140477138

ENST00000371473

2_233

382

501.0

Region

Necessary and sufficient to elicit dendritic processes and synaptic contacts

Hgene

NSMF

chr9:140346817

chr9:140477138

ENST00000371474

2_233

387

506.0

Region

Necessary and sufficient to elicit dendritic processes and synaptic contacts

Hgene

NSMF

chr9:140346817

chr9:140477138

ENST00000371475

2_233

412

531.0

Region

Necessary and sufficient to elicit dendritic processes and synaptic contacts

Hgene

NSMF

chr9:140346817

chr9:140477138

ENST00000437259

2_233

389

508.0

Region

Necessary and sufficient to elicit dendritic processes and synaptic contacts

Hgene

NSMF

chr9:140346817

chr9:140477505

ENST00000265663

2_233

410

529.0

Region

Necessary and sufficient to elicit dendritic processes and synaptic contacts

Hgene

NSMF

chr9:140346817

chr9:140477505

ENST00000371472

2_233

410

472.3333333333333

Region

Necessary and sufficient to elicit dendritic processes and synaptic contacts

Hgene

NSMF

chr9:140346817

chr9:140477505

ENST00000371473

2_233

382

501.0

Region

Necessary and sufficient to elicit dendritic processes and synaptic contacts

Hgene

NSMF

chr9:140346817

chr9:140477505

ENST00000371474

2_233

387

506.0

Region

Necessary and sufficient to elicit dendritic processes and synaptic contacts

Hgene

NSMF

chr9:140346817

chr9:140477505

ENST00000371475

2_233

412

531.0

Region

Necessary and sufficient to elicit dendritic processes and synaptic contacts

Hgene

NSMF

chr9:140346817

chr9:140477505

ENST00000437259

2_233

389

508.0

Region

Necessary and sufficient to elicit dendritic processes and synaptic contacts

Tgene

ZMYND19

chr9:140346817

chr9:140477505

ENST00000298585

158_161

228.0

Compositional bias

Note=Poly-Glu

Tgene

ZMYND19

chr9:140346817

chr9:140477505

ENST00000298585

164_212

228.0

Zinc finger

MYND-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NSMF

chr9:140346817

chr9:140477138

ENST00000339554

2_233

209

328.0

Region

Necessary and sufficient to elicit dendritic processes and synaptic contacts

Hgene

NSMF

chr9:140346817

chr9:140477505

ENST00000339554

2_233

209

328.0

Region

Necessary and sufficient to elicit dendritic processes and synaptic contacts

Tgene

ZMYND19

chr9:140346817

chr9:140477138

ENST00000298585

158_161

180

228.0

Compositional bias

Note=Poly-Glu

Tgene

ZMYND19

chr9:140346817

chr9:140477138

ENST00000298585

164_212

180

228.0

Zinc finger

MYND-type

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Fusion Gene Sequence for NSMF-ZMYND19

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>60544_60544_1_NSMF-ZMYND19_NSMF_chr9_140346817_ENST00000371482_ZMYND19_chr9_140477138_ENST00000298585_length(transcript)=1970nt_BP=1362nt
TCTGGAGTTGAAGGGGAGCCCTGGAAGGCTGTCGCGGGAAGAGCACTGGGTGGGATTTGCCTTTGGGTGGGAGGTGGTGCCAGGAGCCAG
GGAGAGCACTGGCTTCCCACACCGAAGGGGAACTTCCGCAAACACCTGCGCATGGTCGGCAGCCGGAGGGTGAAGGCCCAGACGTTCGCT
GAGCGGCGCGAGCGGAGCTTCAGCCGGTCCTGGAGCGACCCCACCCCCATGAAAGCCGACACTTCCCACGACTCCCGAGACAGTAGGTGC
CCCGCACAGGCCCGCCCACCTTCCCCAGAGCCTCCCCTAGACCCCAGACCCCTGCTGGGGGTCCCCTGCCAGGGCCGCTGGGCTGCGCTT
TTGCACTCCTGAATCTTGGTTTACCTGTTTGTGAGATGGGGACGCCCTCAGCATCTCCGATCGCAAAGGCGGGGCTAACAACGGCCGCGG
CAGTGCTGGCCGGGGGCGCCTGTAGGGCCGTGCCCACCGCCACTCGCAAGAGGCCCTCAGGGGCAGGGGGCTGCGGTGCCCGCCCCCACT
CCCTCCCAGGCGCCCGGCGGACTTGGCTGGAGCTGATGCCTGCACGCGCCTTCCACCGGCCTCGCACCAGGGTCTCCCTTCCCACATCAG
GCCGCTGCCCAGTGGTGTCCACAGGCCTGTCCTGCCGGGCTGGCGGCGACCTCTGTATGGTCCTCCCACTTGCTTGGAGGACCCTCCGGG
ATGGGGCTTTCGGGCCCTGTGGGCCTTGGGGCCATGGCCAGGATAGGAGGTGCTGCCGGGCCTGCTGTCCTGGTGACCCTCTTGCTTCCC
AGGCAGTGACCTGCAGAGCTCCCACTGCACGCTGGACGAGGCCTTCGAGGACCTGGACTGGGACACTGAGAAGGGCCTGGAGGCTGTGGC
CTGCGACACCGAAGGCTTCGTGCCACCAAAGGTCATGGTGAGGCCCAGCCCGGGCAGTGCTCCTCTACACCCCGAGCAGGACTCCGCCCC
AACCCGAGTCCAGCCAGCTCTGCCTGGGACCACGCAGCCTTCTCCAGCTGCCTGGGGGAGGGTGTCTCACAGGGCTATACCCTTGGGCTG
CCTGGCAGCCAGAAGGTAGCCTCATGGGGGCTCCCACAGCCCCTTGGCTTTTGGATGGGCCTGGGGCCCCTGAGCAGCTCTTTGTCTCCG
CAGCTCATTTCCTCCAAGGTGCCCAAGGCTGAGTACATCCCCACTATCATCCGCCGGGATGACCCCTCCATCATCCCCATCCTCTACGAC
CATGAGCACGCAACCTTCGAGGACATCCTTGAGGAGATAGAGAGGAAGCTGAACGTCTACCACAAGGGAGCCAAGATCTGGAAAATGCTG
ATTTTCTGCCAGCTCCGGGAGTTCAACATCTGTGGGCGCTGCCAGGTGGCCCGGTACTGCGGCTCCCAGTGCCAGCAGAAGGACTGGCCT
GCCCACAAGAAGCACTGTCGGGAGAGGAAGCGTCCCTTCCAGCATGAGCTTGAGCCAGAGCGATGACGGGCAGGGGAGCCACACATACTC
ACAGCCCCCGGGCTCTACCCTGGGCACAGCAGAGACAGACTGGTGGTTGAACCTGGAGGTGCCAAAAAAGCCAGCTGCGGGCCCAGGACA
GCTGCCGTGAGACTCCCGATGTCACAGGCAGTCTGTGTGGTTACAGCGCCCCTCAGTGTTCATCTCCAGCAGAGACAACGGAGGAGGCTC
CCACCAGGACGGTTCTCATTATTTATATGTTAATATGTTTGTAAACTCATGTACAGTTTTTTTTGGGGGGGAGGCAATGGGAAGGGTAGA
AATTACAAATAGAATCATTTGCTGTAATCCTTAAATGGCAAACGGTCAGGCCACGTGACTAAAAACTGTCCTGTTGTCGAAGCTTCTCCC

>60544_60544_1_NSMF-ZMYND19_NSMF_chr9_140346817_ENST00000371482_ZMYND19_chr9_140477138_ENST00000298585_length(amino acids)=216AA_BP=
MPGLGLTMTFGGTKPSVSQATASRPFSVSQSRSSKASSSVQWELCRSLPGKQEGHQDSRPGSTSYPGHGPKAHRARKPHPGGSSKQVGGP
YRGRRQPGRTGLWTPLGSGLMWEGRPWCEAGGRRVQASAPAKSAGRLGGSGGGHRSPLPLRASCEWRWARPYRRPRPALPRPLLAPPLRS

--------------------------------------------------------------
>60544_60544_2_NSMF-ZMYND19_NSMF_chr9_140346817_ENST00000371482_ZMYND19_chr9_140477505_ENST00000298585_length(transcript)=2041nt_BP=1362nt
TCTGGAGTTGAAGGGGAGCCCTGGAAGGCTGTCGCGGGAAGAGCACTGGGTGGGATTTGCCTTTGGGTGGGAGGTGGTGCCAGGAGCCAG
GGAGAGCACTGGCTTCCCACACCGAAGGGGAACTTCCGCAAACACCTGCGCATGGTCGGCAGCCGGAGGGTGAAGGCCCAGACGTTCGCT
GAGCGGCGCGAGCGGAGCTTCAGCCGGTCCTGGAGCGACCCCACCCCCATGAAAGCCGACACTTCCCACGACTCCCGAGACAGTAGGTGC
CCCGCACAGGCCCGCCCACCTTCCCCAGAGCCTCCCCTAGACCCCAGACCCCTGCTGGGGGTCCCCTGCCAGGGCCGCTGGGCTGCGCTT
TTGCACTCCTGAATCTTGGTTTACCTGTTTGTGAGATGGGGACGCCCTCAGCATCTCCGATCGCAAAGGCGGGGCTAACAACGGCCGCGG
CAGTGCTGGCCGGGGGCGCCTGTAGGGCCGTGCCCACCGCCACTCGCAAGAGGCCCTCAGGGGCAGGGGGCTGCGGTGCCCGCCCCCACT
CCCTCCCAGGCGCCCGGCGGACTTGGCTGGAGCTGATGCCTGCACGCGCCTTCCACCGGCCTCGCACCAGGGTCTCCCTTCCCACATCAG
GCCGCTGCCCAGTGGTGTCCACAGGCCTGTCCTGCCGGGCTGGCGGCGACCTCTGTATGGTCCTCCCACTTGCTTGGAGGACCCTCCGGG
ATGGGGCTTTCGGGCCCTGTGGGCCTTGGGGCCATGGCCAGGATAGGAGGTGCTGCCGGGCCTGCTGTCCTGGTGACCCTCTTGCTTCCC
AGGCAGTGACCTGCAGAGCTCCCACTGCACGCTGGACGAGGCCTTCGAGGACCTGGACTGGGACACTGAGAAGGGCCTGGAGGCTGTGGC
CTGCGACACCGAAGGCTTCGTGCCACCAAAGGTCATGGTGAGGCCCAGCCCGGGCAGTGCTCCTCTACACCCCGAGCAGGACTCCGCCCC
AACCCGAGTCCAGCCAGCTCTGCCTGGGACCACGCAGCCTTCTCCAGCTGCCTGGGGGAGGGTGTCTCACAGGGCTATACCCTTGGGCTG
CCTGGCAGCCAGAAGGTAGCCTCATGGGGGCTCCCACAGCCCCTTGGCTTTTGGATGGGCCTGGGGCCCCTGAGCAGCTCTTTGTCTCCG
CAGCTCATTTCCTCCAAGGTGCCCAAGGCTGAGTACATCCCCACTATCATCCGCCGGGATGACCCCTCCATCATCCCCATCCTCTACGAC
CATGAGCACGCAACCTTCGAGGACATCCTTGAGGAGATAGAGAGGAAGCTGAACGTCTACCACAAGGGAGCCAAGATCTGGAAAATGCTG
ATTTTCTGCCAGCTCCGGGAGTTCAACATCTGTGGGCGCTGCCAGGTGGCCCGGTACTGCGGCTCCCAGTGCCAGCAGAAGGACTGGCCT
GCCCACAAGAAGCACTGTCGGGAGAGGAAGCGTCCCTTCCAGCATGAGCTTGAGCCAGAGCGATGACGGGCAGGGGAGCCACACATACTC
ACAGCCCCCGGGCTCTACCCTGGGCACAGCAGAGACAGACTGGTGGTTGAACCTGGAGGTGCCAAAAAAGCCAGCTGCGGGCCCAGGACA
GCTGCCGTGAGACTCCCGATGTCACAGGCAGTCTGTGTGGTTACAGCGCCCCTCAGTGTTCATCTCCAGCAGAGACAACGGAGGAGGCTC
CCACCAGGACGGTTCTCATTATTTATATGTTAATATGTTTGTAAACTCATGTACAGTTTTTTTTGGGGGGGAGGCAATGGGAAGGGTAGA
AATTACAAATAGAATCATTTGCTGTAATCCTTAAATGGCAAACGGTCAGGCCACGTGACTAAAAACTGTCCTGTTGTCGAAGCTTCTCCC
CTGGGCCGCCGGGAGCCCCGTGGAGCGCGGCCTGCACGGGAGTTGTGTCCACAAAGGCAAAGTAAAGGGGTGGAATCATCTGGAAGAGGA

>60544_60544_2_NSMF-ZMYND19_NSMF_chr9_140346817_ENST00000371482_ZMYND19_chr9_140477505_ENST00000298585_length(amino acids)=216AA_BP=
MPGLGLTMTFGGTKPSVSQATASRPFSVSQSRSSKASSSVQWELCRSLPGKQEGHQDSRPGSTSYPGHGPKAHRARKPHPGGSSKQVGGP
YRGRRQPGRTGLWTPLGSGLMWEGRPWCEAGGRRVQASAPAKSAGRLGGSGGGHRSPLPLRASCEWRWARPYRRPRPALPRPLLAPPLRS

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Fusion Gene PPI Analysis for NSMF-ZMYND19

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for NSMF-ZMYND19

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for NSMF-ZMYND19

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source