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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NT5C2-ARL3 (FusionGDB2 ID:60599)

Fusion Gene Summary for NT5C2-ARL3

Fusion gene summary

Fusion gene information	Fusion gene name: NT5C2-ARL3
	Fusion gene ID: 60599
		Hgene	Tgene
	Gene symbol	NT5C2	ARL3
	Gene ID	22978	403
	Gene name	5'-nucleotidase, cytosolic II	ADP ribosylation factor like GTPase 3
	Synonyms	GMP\|NT5B\|PNT5\|SPG45\|SPG65\|cN-II	ARFL3\|JBTS35\|RP83
	Cytomap	10q24.32-q24.33	10q24.32
	Type of gene	protein-coding	protein-coding
	Description	cytosolic purine 5'-nucleotidase5'-nucleotidase (purine), cytosolic type BIMP-specific 5'-NTepididymis secretory sperm binding proteinspastic paraplegia 45 (autosomal recessive)	ADP-ribosylation factor-like protein 3ADP-ribosylation factor-like 3ARF-like 3
	Modification date	20200313	20200315
	UniProtAcc	.	P36405
	Ensembl transtripts involved in fusion gene	ENST00000369857, ENST00000343289, ENST00000404739, ENST00000423468, ENST00000470299,	ENST00000260746,
Fusion gene scores	* DoF score	13 X 8 X 9=936	7 X 5 X 5=175
	# samples	17	7
	** MAII score	log2(17/936*10)=-2.4609737834457 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/175*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NT5C2 [Title/Abstract] AND ARL3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NT5C2(104899163)-ARL3(104449700), # samples:2
Anticipated loss of major functional domain due to fusion event.	NT5C2-ARL3 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. NT5C2-ARL3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. NT5C2-ARL3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ARL3	GO:0007264	small GTPase mediated signal transduction	22085962

Fusion gene breakpoints across NT5C2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ARL3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	COAD	TCGA-DM-A28A-01A	NT5C2	chr10	104899163	-	ARL3	chr10	104449700	-
ChimerDB4	COAD	TCGA-DM-A28A-01A	NT5C2	chr10	104934615	-	ARL3	chr10	104449700	-

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Fusion Gene ORF analysis for NT5C2-ARL3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000369857	ENST00000260746	NT5C2	chr10	104899163	-	ARL3	chr10	104449700	-
Frame-shift	ENST00000343289	ENST00000260746	NT5C2	chr10	104934615	-	ARL3	chr10	104449700	-
Frame-shift	ENST00000404739	ENST00000260746	NT5C2	chr10	104899163	-	ARL3	chr10	104449700	-
Frame-shift	ENST00000423468	ENST00000260746	NT5C2	chr10	104899163	-	ARL3	chr10	104449700	-
Frame-shift	ENST00000470299	ENST00000260746	NT5C2	chr10	104934615	-	ARL3	chr10	104449700	-
In-frame	ENST00000343289	ENST00000260746	NT5C2	chr10	104899163	-	ARL3	chr10	104449700	-
In-frame	ENST00000404739	ENST00000260746	NT5C2	chr10	104934615	-	ARL3	chr10	104449700	-
intron-3CDS	ENST00000369857	ENST00000260746	NT5C2	chr10	104934615	-	ARL3	chr10	104449700	-
intron-3CDS	ENST00000423468	ENST00000260746	NT5C2	chr10	104934615	-	ARL3	chr10	104449700	-
intron-3CDS	ENST00000470299	ENST00000260746	NT5C2	chr10	104899163	-	ARL3	chr10	104449700	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000343289	NT5C2	chr10	104899163	-	ENST00000260746	ARL3	chr10	104449700	-	3711	263	1685	2122	145
ENST00000404739	NT5C2	chr10	104934615	-	ENST00000260746	ARL3	chr10	104449700	-	3573	125	1547	1984	145

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000343289	ENST00000260746	NT5C2	chr10	104899163	-	ARL3	chr10	104449700	-	0.67653733	0.32346267
ENST00000404739	ENST00000260746	NT5C2	chr10	104934615	-	ARL3	chr10	104449700	-	0.66262573	0.33737427

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Fusion Genomic Features for NT5C2-ARL3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NT5C2-ARL3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:104899163/chr10:104449700)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ARL3 P36405
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP) (PubMed:16525022, PubMed:18588884). Required for normal cytokinesis and cilia signaling (PubMed:22085962). Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E (PubMed:30269812). Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (PubMed:22085962). Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (By similarity). {ECO:0000250\|UniProtKB:Q9WUL7, ECO:0000269\|PubMed:16525022, ECO:0000269\|PubMed:18588884, ECO:0000269\|PubMed:22085962}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ARL3

chr10:104899163

chr10:104449700

ENST00000260746

126_129

183.0

Nucleotide binding

GTP

Tgene

ARL3

chr10:104899163

chr10:104449700

ENST00000260746

159_161

183.0

Nucleotide binding

GTP

Tgene

ARL3

chr10:104934615

chr10:104449700

ENST00000260746

126_129

183.0

Nucleotide binding

GTP

Tgene

ARL3

chr10:104934615

chr10:104449700

ENST00000260746

159_161

183.0

Nucleotide binding

GTP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NT5C2

chr10:104899163

chr10:104449700

ENST00000343289

549_561

562.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

NT5C2

chr10:104899163

chr10:104449700

ENST00000404739

549_561

562.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

NT5C2

chr10:104934615

chr10:104449700

ENST00000343289

549_561

562.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

NT5C2

chr10:104934615

chr10:104449700

ENST00000404739

549_561

562.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

NT5C2

chr10:104899163

chr10:104449700

ENST00000343289

202_210

562.0

Region

Substrate binding

Hgene

NT5C2

chr10:104899163

chr10:104449700

ENST00000404739

202_210

562.0

Region

Substrate binding

Hgene

NT5C2

chr10:104934615

chr10:104449700

ENST00000343289

202_210

562.0

Region

Substrate binding

Hgene

NT5C2

chr10:104934615

chr10:104449700

ENST00000404739

202_210

562.0

Region

Substrate binding

Tgene

ARL3

chr10:104899163

chr10:104449700

ENST00000260746

24_31

183.0

Nucleotide binding

GTP

Tgene

ARL3

chr10:104899163

chr10:104449700

ENST00000260746

67_71

183.0

Nucleotide binding

GTP

Tgene

ARL3

chr10:104934615

chr10:104449700

ENST00000260746

24_31

183.0

Nucleotide binding

GTP

Tgene

ARL3

chr10:104934615

chr10:104449700

ENST00000260746

67_71

183.0

Nucleotide binding

GTP

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Fusion Gene Sequence for NT5C2-ARL3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>60599_60599_1_NT5C2-ARL3_NT5C2_chr10_104899163_ENST00000343289_ARL3_chr10_104449700_ENST00000260746_length(transcript)=3711nt_BP=263nt
GAGGGCGCGCGTTGAGGCGGCTGCGGCAGTTGCGCGCTGGGATTGTTGCGGTGCGCTGGAGCCGAATACAAAATACAGTTAAAATAAAAT
GTCAACCTCCTGGAGTGATCGGTTACAGAATGCAGCAGATATGCCTGCTAACATGGATAAGCATGCCCTGAAAAAGTATCGTCGAGAAGC
CTATCATCGGGTGTTTGTGAACCGAAGTTTAGCAATGGAAAAGATAAAGTGTTTTGGTTTTGATATGGATTATACCCTTGCTGATATATG
TAATCGACAGTGCAGACAGAAAAAGATTTGAAGAGACGGGTCAGGAACTAGCGGAATTACTGGAGGAAGAAAAACTAAGTTGTGTGCCAG
TGCTCATCTTTGCTAATAAGCAGGATTTGCTCACAGCAGCCCCTGCCTCTGAAATTGCAGAAGGACTGAACCTGCATACCATCCGCGACC
GAGTCTGGCAGATCCAGTCTTGCTCAGCTCTCACAGGAGAGGGCGTTCAGGATGGCATGAACTGGGTCTGCAAAAATGTCAATGCAAAGA
AGAAATAAAATCTAGACGAATGGAGATGCAGGAGCTGCGGGAGCCGAATTCGGTCCTGAAAAACACTAATTTGCTGCTTTCTGACCAAAT
GTTTTTCCATCTGTGTACAGCTCCAGCTGTTTGAAGAGAGGGAACAACACGGTTTAGAAAGAATCCCCATTCCAGCAGTAGATTTAACTG
ATCTCTGAGGTTCAGTATCATTTTTCAAATAAAGGAATTATATTATTTCCTCTGCATAATTGAAATAGTATTAAATGTCTCAAAGCACAT
GATTAGAAAATGAGATCTTTTAAATGAGCAAGAGATTGCATTGCAGTTTAGACAATTCCAGTGGGCTTTTTTTTCCTCTCAAAAAAAAAA
AAAGAAAAAGAAAAAGAGGAAGAAGCAGCTTTGCTGAGTTCATTTATTTACTGACCCGTCCCTTGCATTCCCTCCATGGTTTTGAAACCA
CAGACAGTGTTTGCTGGTGCTGTCAGTGATTTTTACCGTCACTAGCCCAGCCAGGCTTCAGTCTGTCCGACAGGAAGCTGCTGGGTGGGG
GTGGGGGGAGAAAAGGCAGATAATTAAACCATCTCATCGTCTTGCAGGTCGGAGACTACGTATGTAATCCTCACTCTTTGGACAGAAAAA
AAAAAAAAAGTCTTTCTTGCAGACAAGTCACTACAGAAACATACCCCATCCCACCCACCCCTGCCTCTGCCCCAGCCAGCCACACAGAGA
AGCAAATTCTTATGACTTTTGACTGTAATGACATCTGGAATGTAAGGAGAGGTGGGAGGTTTAATTCCAGAAAAATTACAAGGTCCTTAA
AAAGCTCTCACATCGAGGGCTCAGGCTAGCGTAAACAGGCTTTCTCCAGCTCAGTGGAGCAGTGAGCAGCCGACTCTGAGATTAGCTGGC
TTCTCCACGGCCGTCCTATAGACAGGATTTCTAAAGCTCAAAGAATTCTGTGTTTAAACGATCACAATAGGCCGCTGCTATCAGATTTTA
GAAATAAATGCAGCTTTACCATGAACCTGCTCCACTGAGAAAAGCCAGGCAGATCGATTTTTAGATCAATTTTTACAGTGCTGGCAACTT
GGTGGTGTGGGATGCTCCTGGATGGAGAGGGTTTGCTGCTGGGGAGGACATGGGTGTGTGTGTGACTGCAGGGGTCGTGTCCAAGGAATC
AAGAGTCACCCCAGCTGCTGGGCTCCTCTGCCTCTCTGCAGCAGAATGTCCGTCCTCTGTTGATTGATTGGAGAGGAATAGCAGAACATT
TCTCCTGCCCCTCGTTGCAAAACGAGCTTGTTTCCCTGAACCTCAGAAATCCTCAGCTTCAAACATGGGGAAACAGGCCAGAGCATTGCC
CGGCTCCTGAATTAAACTCTGTTCTGGTGCCTGAGCTCAGGGGTTTTCAGAGAATGAATAAGAGACTGTCCAGTGACTGGTGGGTCCCTG
GGGGCCAGCTGCCTTCTCATCCTGGGAGGTGGCCCTTCCCAAGCCCATCAGGGCGTGTGAGCAGACTGAAGGGGCCGCTGCAGCCCCTGG
CCCTCAATACCCAGCTGCTTCTGGCTAAGAGTGCAGCAGAGACTGAGGCATAGCCAGCTTCAAAAGCGATCTGACATGAAAGTCATTAAC
AAAGCCAGCCGTGAAAAGGTGCCCCAGAGTTGCTGTGGACAGACCTGTAAGGACTTGCAAAACAAAAGAAAGTGAGGGGTTTTTTTAACC
TCAGAGCTAGCTGCTCTCTGCAGCCTCCTCCACTGGCTTCTCTGGCTCACCCAAGCTCTCCCTTACAGAGGCAACACAGAATTATAAGGA
ATCAGAAATCCCCCTTCTACCAGGCTGCAAATGTGGCTCTAGCACTTGCAAATTGTTTTTTCTTCCGAATAGTTCAGCAGGGACAAGTTA
TCTGAGGGGCAAAATGCCTGCTTGGAGGTCTGCAATTTTGGAACACTGCAGTATGGAACTTTGGCATTGGAGGGTCTGTAAAATATTTTT
GTTCTTTTACCACCAACTTAGGGGACTGTTTTAAAGAGCCATCCCAAGGCCTCTCCTAGCAGGCAGAAGCCACTCCTCTGATAACGGCCT
CTGTAAATGTTCTGATTTGCTCTCAGCTGCAGAGACACAGAGACACTGCAGATGTCACACGCTTTCATCTTCCCTTTGAGCCCTTTTGAA
CCCTCCTGGGGCTCTGGGGTAGATGAGAGAAGCCTGAAAAAGGCAGAGTTTGAAAGCTCCCATTTAAAAACAAAATACTTTTTAAAGCCC
TCTTGCCTCTTCCCTGCCCACTCCTGCCCCCTGACCAGAAGACAGAATTTGAAGCTGGAAAGGGAAGACCCCTTTTCCCCTCCTCCTGTC
CCCAGTGAGTCTTAGCGAGACTTTTGCCCTGCGCACAATTGCATCTGAATGTGCGGGGGAGAGGGCTGGGGGCCGGAGGGCAGGCAAGGC
CTGGGGGGTGCTCGTGATATGTGCTCAAGCCAGTTGTGGGAAAAACTCGAGTCCTCCCCTCCTCCCGACCTACCCCGTGTGGCTGCTTTT
GGCTGGATTCCCTGCACCCAGTGCAACACACCCTTTCCCCTTCACTCTCCCTTGGTTACTATGGAAACAAGGGTGTCATTGATGTGGGCT
GAGCTGGGGAACATGTCGGTGCACAGCTGAAAGTCAGCGATTATGCCGGCGGTTAGAAATGTGCCAGGGTTAAAGGAGTCCGCAGCTCCC
ACGGCTGCTGGGAGGACATGGTCCTGCCCCCTTCCTTCCTCCCTCCCTCCGTCTCCACTTCTCTCTCCTTGCTTTTGACAAATTTCTTTA
TTCCCCTCTGGACTAAAGTAGTGGCTATTTTTGTGCCACTCTGCGCCCCACCCTCACTGTTGGCCGCTCCTTATCCGGCCTGGCCTGGAG
GGTGACACCATGTCACCCTCACCAGGACTCGTCTCTCCATTCCCGTCAGAGTTTGCTTTGATTTCCCTTTCCTTTCCTTCTCGGGGACCA
GTTCTTACTTCCTTTTATTTTTAGCTCTGCACTCCATGTGGTTTCAGGGTTCAGTCTGATCCATCAAAAGGTTCTTTTTTTATAATCCCT
TTTGAAAATGATAATCAAAGGAAGAGATGTGGTGTTTGGTCATGTGGAAAACTCAATGTATAATTTAGACGTCTGTCAAAAATCCGACAA

>60599_60599_1_NT5C2-ARL3_NT5C2_chr10_104899163_ENST00000343289_ARL3_chr10_104449700_ENST00000260746_length(amino acids)=145AA_BP=
MQGSCPRNQESPQLLGSSASLQQNVRPLLIDWRGIAEHFSCPSLQNELVSLNLRNPQLQTWGNRPEHCPAPELNSVLVPELRGFQRMNKR

--------------------------------------------------------------
>60599_60599_2_NT5C2-ARL3_NT5C2_chr10_104934615_ENST00000404739_ARL3_chr10_104449700_ENST00000260746_length(transcript)=3573nt_BP=125nt
AATACAAAATACAGTTAAAATAAAATGTCAACCTCCTGGAGTGATCGGTTACAGAATGCAGCAGATATGCCTGCTAACATGGATAAGCAT
GCCCTGAAAAAGTATCGTCGAGAAGCCTATCATCGATATATGTAATCGACAGTGCAGACAGAAAAAGATTTGAAGAGACGGGTCAGGAAC
TAGCGGAATTACTGGAGGAAGAAAAACTAAGTTGTGTGCCAGTGCTCATCTTTGCTAATAAGCAGGATTTGCTCACAGCAGCCCCTGCCT
CTGAAATTGCAGAAGGACTGAACCTGCATACCATCCGCGACCGAGTCTGGCAGATCCAGTCTTGCTCAGCTCTCACAGGAGAGGGCGTTC
AGGATGGCATGAACTGGGTCTGCAAAAATGTCAATGCAAAGAAGAAATAAAATCTAGACGAATGGAGATGCAGGAGCTGCGGGAGCCGAA
TTCGGTCCTGAAAAACACTAATTTGCTGCTTTCTGACCAAATGTTTTTCCATCTGTGTACAGCTCCAGCTGTTTGAAGAGAGGGAACAAC
ACGGTTTAGAAAGAATCCCCATTCCAGCAGTAGATTTAACTGATCTCTGAGGTTCAGTATCATTTTTCAAATAAAGGAATTATATTATTT
CCTCTGCATAATTGAAATAGTATTAAATGTCTCAAAGCACATGATTAGAAAATGAGATCTTTTAAATGAGCAAGAGATTGCATTGCAGTT
TAGACAATTCCAGTGGGCTTTTTTTTCCTCTCAAAAAAAAAAAAAGAAAAAGAAAAAGAGGAAGAAGCAGCTTTGCTGAGTTCATTTATT
TACTGACCCGTCCCTTGCATTCCCTCCATGGTTTTGAAACCACAGACAGTGTTTGCTGGTGCTGTCAGTGATTTTTACCGTCACTAGCCC
AGCCAGGCTTCAGTCTGTCCGACAGGAAGCTGCTGGGTGGGGGTGGGGGGAGAAAAGGCAGATAATTAAACCATCTCATCGTCTTGCAGG
TCGGAGACTACGTATGTAATCCTCACTCTTTGGACAGAAAAAAAAAAAAAAGTCTTTCTTGCAGACAAGTCACTACAGAAACATACCCCA
TCCCACCCACCCCTGCCTCTGCCCCAGCCAGCCACACAGAGAAGCAAATTCTTATGACTTTTGACTGTAATGACATCTGGAATGTAAGGA
GAGGTGGGAGGTTTAATTCCAGAAAAATTACAAGGTCCTTAAAAAGCTCTCACATCGAGGGCTCAGGCTAGCGTAAACAGGCTTTCTCCA
GCTCAGTGGAGCAGTGAGCAGCCGACTCTGAGATTAGCTGGCTTCTCCACGGCCGTCCTATAGACAGGATTTCTAAAGCTCAAAGAATTC
TGTGTTTAAACGATCACAATAGGCCGCTGCTATCAGATTTTAGAAATAAATGCAGCTTTACCATGAACCTGCTCCACTGAGAAAAGCCAG
GCAGATCGATTTTTAGATCAATTTTTACAGTGCTGGCAACTTGGTGGTGTGGGATGCTCCTGGATGGAGAGGGTTTGCTGCTGGGGAGGA
CATGGGTGTGTGTGTGACTGCAGGGGTCGTGTCCAAGGAATCAAGAGTCACCCCAGCTGCTGGGCTCCTCTGCCTCTCTGCAGCAGAATG
TCCGTCCTCTGTTGATTGATTGGAGAGGAATAGCAGAACATTTCTCCTGCCCCTCGTTGCAAAACGAGCTTGTTTCCCTGAACCTCAGAA
ATCCTCAGCTTCAAACATGGGGAAACAGGCCAGAGCATTGCCCGGCTCCTGAATTAAACTCTGTTCTGGTGCCTGAGCTCAGGGGTTTTC
AGAGAATGAATAAGAGACTGTCCAGTGACTGGTGGGTCCCTGGGGGCCAGCTGCCTTCTCATCCTGGGAGGTGGCCCTTCCCAAGCCCAT
CAGGGCGTGTGAGCAGACTGAAGGGGCCGCTGCAGCCCCTGGCCCTCAATACCCAGCTGCTTCTGGCTAAGAGTGCAGCAGAGACTGAGG
CATAGCCAGCTTCAAAAGCGATCTGACATGAAAGTCATTAACAAAGCCAGCCGTGAAAAGGTGCCCCAGAGTTGCTGTGGACAGACCTGT
AAGGACTTGCAAAACAAAAGAAAGTGAGGGGTTTTTTTAACCTCAGAGCTAGCTGCTCTCTGCAGCCTCCTCCACTGGCTTCTCTGGCTC
ACCCAAGCTCTCCCTTACAGAGGCAACACAGAATTATAAGGAATCAGAAATCCCCCTTCTACCAGGCTGCAAATGTGGCTCTAGCACTTG
CAAATTGTTTTTTCTTCCGAATAGTTCAGCAGGGACAAGTTATCTGAGGGGCAAAATGCCTGCTTGGAGGTCTGCAATTTTGGAACACTG
CAGTATGGAACTTTGGCATTGGAGGGTCTGTAAAATATTTTTGTTCTTTTACCACCAACTTAGGGGACTGTTTTAAAGAGCCATCCCAAG
GCCTCTCCTAGCAGGCAGAAGCCACTCCTCTGATAACGGCCTCTGTAAATGTTCTGATTTGCTCTCAGCTGCAGAGACACAGAGACACTG
CAGATGTCACACGCTTTCATCTTCCCTTTGAGCCCTTTTGAACCCTCCTGGGGCTCTGGGGTAGATGAGAGAAGCCTGAAAAAGGCAGAG
TTTGAAAGCTCCCATTTAAAAACAAAATACTTTTTAAAGCCCTCTTGCCTCTTCCCTGCCCACTCCTGCCCCCTGACCAGAAGACAGAAT
TTGAAGCTGGAAAGGGAAGACCCCTTTTCCCCTCCTCCTGTCCCCAGTGAGTCTTAGCGAGACTTTTGCCCTGCGCACAATTGCATCTGA
ATGTGCGGGGGAGAGGGCTGGGGGCCGGAGGGCAGGCAAGGCCTGGGGGGTGCTCGTGATATGTGCTCAAGCCAGTTGTGGGAAAAACTC
GAGTCCTCCCCTCCTCCCGACCTACCCCGTGTGGCTGCTTTTGGCTGGATTCCCTGCACCCAGTGCAACACACCCTTTCCCCTTCACTCT
CCCTTGGTTACTATGGAAACAAGGGTGTCATTGATGTGGGCTGAGCTGGGGAACATGTCGGTGCACAGCTGAAAGTCAGCGATTATGCCG
GCGGTTAGAAATGTGCCAGGGTTAAAGGAGTCCGCAGCTCCCACGGCTGCTGGGAGGACATGGTCCTGCCCCCTTCCTTCCTCCCTCCCT
CCGTCTCCACTTCTCTCTCCTTGCTTTTGACAAATTTCTTTATTCCCCTCTGGACTAAAGTAGTGGCTATTTTTGTGCCACTCTGCGCCC
CACCCTCACTGTTGGCCGCTCCTTATCCGGCCTGGCCTGGAGGGTGACACCATGTCACCCTCACCAGGACTCGTCTCTCCATTCCCGTCA
GAGTTTGCTTTGATTTCCCTTTCCTTTCCTTCTCGGGGACCAGTTCTTACTTCCTTTTATTTTTAGCTCTGCACTCCATGTGGTTTCAGG
GTTCAGTCTGATCCATCAAAAGGTTCTTTTTTTATAATCCCTTTTGAAAATGATAATCAAAGGAAGAGATGTGGTGTTTGGTCATGTGGA

>60599_60599_2_NT5C2-ARL3_NT5C2_chr10_104934615_ENST00000404739_ARL3_chr10_104449700_ENST00000260746_length(amino acids)=145AA_BP=
MQGSCPRNQESPQLLGSSASLQQNVRPLLIDWRGIAEHFSCPSLQNELVSLNLRNPQLQTWGNRPEHCPAPELNSVLVPELRGFQRMNKR

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Fusion Gene PPI Analysis for NT5C2-ARL3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for NT5C2-ARL3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for NT5C2-ARL3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source