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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:NT5DC3-FBXW8 (FusionGDB2 ID:60637) |
Fusion Gene Summary for NT5DC3-FBXW8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NT5DC3-FBXW8 | Fusion gene ID: 60637 | Hgene | Tgene | Gene symbol | NT5DC3 | FBXW8 | Gene ID | 51559 | 26259 |
| Gene name | 5'-nucleotidase domain containing 3 | F-box and WD repeat domain containing 8 | |
| Synonyms | TU12B1-TY|TU12B1TY | FBW6|FBW8|FBX29|FBXO29|FBXW6 | |
| Cytomap | 12q23.3 | 12q24.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 5'-nucleotidase domain-containing protein 3 | F-box/WD repeat-containing protein 8F-box and WD-40 domain protein 8F-box and WD-40 domain-containing protein 8F-box only protein 29 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q8N3Y1 | |
| Ensembl transtripts involved in fusion gene | ENST00000392876, ENST00000465502, | ENST00000551773, ENST00000309909, ENST00000455858, | |
| Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 12 X 12 X 4=576 |
| # samples | 4 | 14 | |
| ** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(14/576*10)=-2.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NT5DC3 [Title/Abstract] AND FBXW8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | NT5DC3(104234727)-FBXW8(117365828), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | FBXW8 | GO:0008283 | cell proliferation | 24362026 |
| Tgene | FBXW8 | GO:0016567 | protein ubiquitination | 18498745|24362026 |
| Tgene | FBXW8 | GO:0050775 | positive regulation of dendrite morphogenesis | 21572988 |
| Fusion gene breakpoints across NT5DC3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across FBXW8 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-CD-A486-01A | NT5DC3 | chr12 | 104234727 | - | FBXW8 | chr12 | 117365828 | + |
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Fusion Gene ORF analysis for NT5DC3-FBXW8 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000392876 | ENST00000551773 | NT5DC3 | chr12 | 104234727 | - | FBXW8 | chr12 | 117365828 | + |
| In-frame | ENST00000392876 | ENST00000309909 | NT5DC3 | chr12 | 104234727 | - | FBXW8 | chr12 | 117365828 | + |
| In-frame | ENST00000392876 | ENST00000455858 | NT5DC3 | chr12 | 104234727 | - | FBXW8 | chr12 | 117365828 | + |
| intron-3CDS | ENST00000465502 | ENST00000309909 | NT5DC3 | chr12 | 104234727 | - | FBXW8 | chr12 | 117365828 | + |
| intron-3CDS | ENST00000465502 | ENST00000455858 | NT5DC3 | chr12 | 104234727 | - | FBXW8 | chr12 | 117365828 | + |
| intron-intron | ENST00000465502 | ENST00000551773 | NT5DC3 | chr12 | 104234727 | - | FBXW8 | chr12 | 117365828 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000392876 | NT5DC3 | chr12 | 104234727 | - | ENST00000309909 | FBXW8 | chr12 | 117365828 | + | 2192 | 249 | 255 | 1727 | 490 |
| ENST00000392876 | NT5DC3 | chr12 | 104234727 | - | ENST00000455858 | FBXW8 | chr12 | 117365828 | + | 4704 | 249 | 255 | 1727 | 490 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000392876 | ENST00000309909 | NT5DC3 | chr12 | 104234727 | - | FBXW8 | chr12 | 117365828 | + | 0.004177675 | 0.9958223 |
| ENST00000392876 | ENST00000455858 | NT5DC3 | chr12 | 104234727 | - | FBXW8 | chr12 | 117365828 | + | 0.002628945 | 0.9973711 |
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Fusion Genomic Features for NT5DC3-FBXW8 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| NT5DC3 | chr12 | 104234726 | - | FBXW8 | chr12 | 117365827 | + | 4.89E-09 | 1 |
| NT5DC3 | chr12 | 104234726 | - | FBXW8 | chr12 | 117365827 | + | 4.89E-09 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for NT5DC3-FBXW8 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:104234727/chr12:117365828) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | FBXW8 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695). {ECO:0000269|PubMed:18498745, ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:24793695}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NT5DC3 | chr12:104234727 | chr12:117365828 | ENST00000392876 | - | 1 | 14 | 4_7 | 69 | 549.0 | Compositional bias | Note=Poly-Ala |
| Tgene | FBXW8 | chr12:104234727 | chr12:117365828 | ENST00000309909 | 0 | 11 | 113_159 | 106 | 599.0 | Domain | F-box | |
| Tgene | FBXW8 | chr12:104234727 | chr12:117365828 | ENST00000455858 | 0 | 11 | 113_159 | 40 | 533.0 | Domain | F-box | |
| Tgene | FBXW8 | chr12:104234727 | chr12:117365828 | ENST00000309909 | 0 | 11 | 197_245 | 106 | 599.0 | Repeat | Note=WD 1 | |
| Tgene | FBXW8 | chr12:104234727 | chr12:117365828 | ENST00000309909 | 0 | 11 | 254_294 | 106 | 599.0 | Repeat | Note=WD 2 | |
| Tgene | FBXW8 | chr12:104234727 | chr12:117365828 | ENST00000309909 | 0 | 11 | 297_336 | 106 | 599.0 | Repeat | Note=WD 3 | |
| Tgene | FBXW8 | chr12:104234727 | chr12:117365828 | ENST00000309909 | 0 | 11 | 430_470 | 106 | 599.0 | Repeat | Note=WD 4 | |
| Tgene | FBXW8 | chr12:104234727 | chr12:117365828 | ENST00000309909 | 0 | 11 | 473_510 | 106 | 599.0 | Repeat | Note=WD 5 | |
| Tgene | FBXW8 | chr12:104234727 | chr12:117365828 | ENST00000455858 | 0 | 11 | 197_245 | 40 | 533.0 | Repeat | Note=WD 1 | |
| Tgene | FBXW8 | chr12:104234727 | chr12:117365828 | ENST00000455858 | 0 | 11 | 254_294 | 40 | 533.0 | Repeat | Note=WD 2 | |
| Tgene | FBXW8 | chr12:104234727 | chr12:117365828 | ENST00000455858 | 0 | 11 | 297_336 | 40 | 533.0 | Repeat | Note=WD 3 | |
| Tgene | FBXW8 | chr12:104234727 | chr12:117365828 | ENST00000455858 | 0 | 11 | 430_470 | 40 | 533.0 | Repeat | Note=WD 4 | |
| Tgene | FBXW8 | chr12:104234727 | chr12:117365828 | ENST00000455858 | 0 | 11 | 473_510 | 40 | 533.0 | Repeat | Note=WD 5 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NT5DC3 | chr12:104234727 | chr12:117365828 | ENST00000392876 | - | 1 | 14 | 251_259 | 69 | 549.0 | Region | Substrate binding |
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Fusion Gene Sequence for NT5DC3-FBXW8 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >60637_60637_1_NT5DC3-FBXW8_NT5DC3_chr12_104234727_ENST00000392876_FBXW8_chr12_117365828_ENST00000309909_length(transcript)=2192nt_BP=249nt GCAGAGCGGCGCGGCGGCGGTGGCGGCAGCAGGCAGCAGGCATGACCATGGCAGCGGCGGCGGTGGTGGCACGCGGGGCCGGGGCGAGGG CAGCGACAGCGGCGGCTTTGCGGGGTGGCTGCGGGACCGCGGCTCGGGGGCGGCCGTGTGCGGGCCCCGCCCGGCCCTTGTGCACTGCAC CCGGGACCGCCCCGGACATGAAGCGCTACCTGTGGGAGCGCTACCGGGAGGCGAAGAGAAGCACAGAAGAATGAAATGAATGATGTGCCT TTCTTTGATATCCAACTGCCTTACGAATTGGCAATCAATATATTTCAGTATCTGGACAGGAAAGAACTAGGAAGATGTGCACAGGTGAGC AAGACGTGGAAGGTGATTGCAGAGGATGAGGTGCTGTGGTACAGGCTGTGCCAGCAGGAAGGGCACCTTCCGGATAGCAGCATCTCTGAC TATTCTTGCTGGAAGCTCATCTTCCAAGAGTGCCGAGCCAAGGAACACATGTTACGAACCAACTGGAAGAATCGCAAAGGTGCCGTGAGC GAGCTGGAGCATGTTCCTGACACAGTTTTGTGTGATGTGCATTCTCACGATGGTGTGGTCATTGCGGGATATACATCAGGGGATGTGAGA GTGTGGGACACCCGCACCTGGGACTACGTAGCCCCCTTCCTGGAATCAGAGGACGAGGAGGATGAGCCTGGAATGCAGCCAAATGTCTCC TTTGTGAGGATAAACAGCTCGTTGGCAGTAGCAGCTTATGAGGATGGGTTTCTTAATATTTGGGATTTAAGGACCGGAAAGTACCCTGTT CATCGTTTTGAGCACGATGCAAGAATACAGGCACTAGCCCTCAGCCAGGACGATGCAACCGTGGCCACAGCTTCTGCTTTTGATGTCGTG ATGTTATCCCCCAATGAGGAGGGGTACTGGCAGATAGCTGCGGAATTTGAAGTTCCGAAACTGGTTCAGTACCTTGAAATAGTTCCAGAA ACCAGAAGGTACCCTGTGGCAGTAGCCGCTGCTGGAGATCTGATGTACCTGCTCAAAGCCGAAGACTCCGCCAGAACCCTCCTTTACGCC CACGGCCCGCCTGTCACATGTCTAGACGTCTCGGCCAACCAAGTTGCTTTTGGTGTACAGGGTCTGGGATGGGTGTACGAAGGAAGCAAG ATCCTGGTGTATAGCCTGGAAGCAGGACGCCGCCTCTTGAAGCTGGGTAACGTTCTCCGTGACTTCACGTGTGTCAACCTCAGCGACAGC CCTCCCAACCTCATGGTCAGTGGCAACATGGACGGGAGGGTGAGGATCCACGACCTCCGCAGTGGTAACATCGCCCTGTCGCTCTCCGCC CATCAGCTCAGGGTCTCTGCTGTGCAGATGGATGACTGGAAGATCGTCAGTGGAGGCGAGGAAGGCCTGGTGTCCGTGTGGGATTATCGG ATGAACCAGAAGCTGTGGGAGGTGTATTCCGGGCACCCGGTGCAGCACATCTCATTCAGCAGCCACAGCCTCATCACGGCCAACGTGCCT TACCAGACGGTAATGCGAAACGCCGACCTGGACAGCTTCACTACTCACAGGAGACACCGGGGGCTGATCCGCGCCTATGAGTTTGCGGTG GACCAGCTGGCCTTCCAGAGCCCTCTCCCTGTCTGCCGTTCATCCTGTGACGCCATGGCCACTCACTACTACGACCTCGCACTGGCCTTT CCCTATAACCATGTTTAGGGATGTGCCTCAGTTGGGAGCAAGGAGAAAAATGGGAAGAACCAGTTTTATCCATCTTAAAACGCCAGGCAC CTCTTCACAGGTGGTAAACATTTAGGGGAAGAAAGCAGCCCAGGGTGCCATGCCTGACAGCACGCATCTCCCTGACCCCTGCACTTCCCC CAGCGCCTGGGGCAAGCTGGCGTGTGCCAGGGCTCGAGTCCCACGTGCTGCCAACTCAAACATAGCCTCCTTCCCCACCCAGCTGGCCAC CCTGGCCTCAGCTCCCTCAGGACGCCTCAGGGATCTCGCTGCGCGGTCCTATACGGTCCCTGCTTAGCCAGCTTCTGTGTGTCCGCCCTC CCAGCTCCAGCCCTGCAGGCCGTCTTTTCCGTCTCCAGCCCCTTACCTCTTTTCCTCCGAGGGCCTTTGGATGTGCTTGTTCCTGGCCTC >60637_60637_1_NT5DC3-FBXW8_NT5DC3_chr12_104234727_ENST00000392876_FBXW8_chr12_117365828_ENST00000309909_length(amino acids)=490AA_BP=0 MNDVPFFDIQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLIFQECRAKEHMLRTNWKNR KGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRT GKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVAVAAAGDLMYLLKAEDSAR TLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIA LSLSAHQLRVSAVQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLIRA -------------------------------------------------------------- >60637_60637_2_NT5DC3-FBXW8_NT5DC3_chr12_104234727_ENST00000392876_FBXW8_chr12_117365828_ENST00000455858_length(transcript)=4704nt_BP=249nt GCAGAGCGGCGCGGCGGCGGTGGCGGCAGCAGGCAGCAGGCATGACCATGGCAGCGGCGGCGGTGGTGGCACGCGGGGCCGGGGCGAGGG CAGCGACAGCGGCGGCTTTGCGGGGTGGCTGCGGGACCGCGGCTCGGGGGCGGCCGTGTGCGGGCCCCGCCCGGCCCTTGTGCACTGCAC CCGGGACCGCCCCGGACATGAAGCGCTACCTGTGGGAGCGCTACCGGGAGGCGAAGAGAAGCACAGAAGAATGAAATGAATGATGTGCCT TTCTTTGATATCCAACTGCCTTACGAATTGGCAATCAATATATTTCAGTATCTGGACAGGAAAGAACTAGGAAGATGTGCACAGGTGAGC AAGACGTGGAAGGTGATTGCAGAGGATGAGGTGCTGTGGTACAGGCTGTGCCAGCAGGAAGGGCACCTTCCGGATAGCAGCATCTCTGAC TATTCTTGCTGGAAGCTCATCTTCCAAGAGTGCCGAGCCAAGGAACACATGTTACGAACCAACTGGAAGAATCGCAAAGGTGCCGTGAGC GAGCTGGAGCATGTTCCTGACACAGTTTTGTGTGATGTGCATTCTCACGATGGTGTGGTCATTGCGGGATATACATCAGGGGATGTGAGA GTGTGGGACACCCGCACCTGGGACTACGTAGCCCCCTTCCTGGAATCAGAGGACGAGGAGGATGAGCCTGGAATGCAGCCAAATGTCTCC TTTGTGAGGATAAACAGCTCGTTGGCAGTAGCAGCTTATGAGGATGGGTTTCTTAATATTTGGGATTTAAGGACCGGAAAGTACCCTGTT CATCGTTTTGAGCACGATGCAAGAATACAGGCACTAGCCCTCAGCCAGGACGATGCAACCGTGGCCACAGCTTCTGCTTTTGATGTCGTG ATGTTATCCCCCAATGAGGAGGGGTACTGGCAGATAGCTGCGGAATTTGAAGTTCCGAAACTGGTTCAGTACCTTGAAATAGTTCCAGAA ACCAGAAGGTACCCTGTGGCAGTAGCCGCTGCTGGAGATCTGATGTACCTGCTCAAAGCCGAAGACTCCGCCAGAACCCTCCTTTACGCC CACGGCCCGCCTGTCACATGTCTAGACGTCTCGGCCAACCAAGTTGCTTTTGGTGTACAGGGTCTGGGATGGGTGTACGAAGGAAGCAAG ATCCTGGTGTATAGCCTGGAAGCAGGACGCCGCCTCTTGAAGCTGGGTAACGTTCTCCGTGACTTCACGTGTGTCAACCTCAGCGACAGC CCTCCCAACCTCATGGTCAGTGGCAACATGGACGGGAGGGTGAGGATCCACGACCTCCGCAGTGGTAACATCGCCCTGTCGCTCTCCGCC CATCAGCTCAGGGTCTCTGCTGTGCAGATGGATGACTGGAAGATCGTCAGTGGAGGCGAGGAAGGCCTGGTGTCCGTGTGGGATTATCGG ATGAACCAGAAGCTGTGGGAGGTGTATTCCGGGCACCCGGTGCAGCACATCTCATTCAGCAGCCACAGCCTCATCACGGCCAACGTGCCT TACCAGACGGTAATGCGAAACGCCGACCTGGACAGCTTCACTACTCACAGGAGACACCGGGGGCTGATCCGCGCCTATGAGTTTGCGGTG GACCAGCTGGCCTTCCAGAGCCCTCTCCCTGTCTGCCGTTCATCCTGTGACGCCATGGCCACTCACTACTACGACCTCGCACTGGCCTTT CCCTATAACCATGTTTAGGGATGTGCCTCAGTTGGGAGCAAGGAGAAAAATGGGAAGAACCAGTTTTATCCATCTTAAAACGCCAGGCAC CTCTTCACAGGTGGTAAACATTTAGGGGAAGAAAGCAGCCCAGGGTGCCATGCCTGACAGCACGCATCTCCCTGACCCCTGCACTTCCCC CAGCGCCTGGGGCAAGCTGGCGTGTGCCAGGGCTCGAGTCCCACGTGCTGCCAACTCAAACATAGCCTCCTTCCCCACCCAGCTGGCCAC CCTGGCCTCAGCTCCCTCAGGACGCCTCAGGGATCTCGCTGCGCGGTCCTATACGGTCCCTGCTTAGCCAGCTTCTGTGTGTCCGCCCTC CCAGCTCCAGCCCTGCAGGCCGTCTTTTCCGTCTCCAGCCCCTTACCTCTTTTCCTCCGAGGGCCTTTGGATGTGCTTGTTCCTGGCCTC CAAGGCAATAACCTCCATGTCCTTTTCCCTGTATTTACTTGGGGTGCTCTTCTGTGACACTTGCCACCACCACCTTCCAGTAGCAAGCTG GTAGAGCTGTACTTTTTCTTCACAGCTTTTACCATGGTTTATAATTATATACTTATACAGTTTAGTCATCAATGACTATTTTGCTTACTA TTGTGTCTATGATATGTGATACAAAGCAAATATTTTCTAAATATTCATTGACTAAACAGCCATCAAGATGAAACAGGACAGGAGAGAACT GTTCAGTGTGATACAGAGCTGCCATTTCCAAAGTATTCTGGAAGCAAGCCATTGCCTTACTCTTGATTTTCAACAGTTCTAAACAGCAAC AGCATCCACCTAATATACCTTCAGAATATCAAAGCGAAAACTGATAGAACTACAAAGAGAAATAAAATCCATTCTCACGGCAGGCAAATC AGTGAGAAAAATGTAAAGATCTGGAGGATTTACTTAGTATCGCTAACAAGCTGGATCCAGTAGATGCGTATGGAATTTCAAATACACATA GACGATGCACAAAAAACCACCCTGTACGAAGGCCACAAAGAACAGCTCAGATGCACAAAGATTCACACCATACAGGCCAAATTATAGAAT CCCCCAACCCCAAGACACTGCACCCTATGGGCTATACCCTCAGGCAGGGCCCTGCTTTTCTAGGAATTGACTCCAATGCAGAATAGTGAG AAATCAACAAAAAGCAAAATAAGACAATTCCAGACACTCCTGAATTTACTTGGATTTAAAGAGGTTAATAAAAACAAACTATAAACTCTC TAGACTGGGCTGACAGTAAAAGCACAGAATACAAAACCCAGGGGATGGGGCTGGGAGGGGCTGTGAGGGGCTGGCACCTCAGCTCAGAAA AGGTAGCAGCAATCCCAAAGCAGCAGAAGGCAGGGGTTAAATCAGGATAAAAACAGACATCAGTGGAATCGAAAACCAATAGTTAGTTAA TATAAAGCCAGAAGGTTTTGTTTTTTTTCAGGTGGGGTCTCGCTCTGTCACCTAGACTAGACTGGAGTGCAATGGCCTGATCTCGGCTCA CTGCAACCTCTGCCTCCCGAGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCGTCCGCTACCACAACTGGCT AATTTTTACATTTTTAGTAGAGACGGGGGATATTGCTATGTTGGCCAGGCTGGTCTCAAACTTCTGACCTCAAATGATTGCCTGCCTCAG CCTCCCAAAGTGCTGGGATTACAGGTGTAAGTCACTGTACCCAGCCCAAAAGCAGTTTAAAAAAAAAAAAGACAAAATATACAACTCTTG ATAAAACATAAAGGTACAGTGGTCTATGAGGAAGAGAAAAGGTACCTGAGGATGCAGAAGTACCTACCACATGGGAACCGTTTGTCCACA CTCATTCCAGAGAAAACCGAGTCCTCTCAGTTGCACACGTGTACGTATCAGTGGGAAGTGCTTGCCATTACTCCAAAGCCTAGAACCTTC ACGTCATGAAGGTTCTGGAAGGTTTTTCAGATTGCTTAAGATACGCAGCCATTCCATATTCATCTCCAACTACACAGGGGAACGGAGCAG ATAGAGCTGCGACTGGGAAGCGTCACCTTCCCGTCCAGAGCGCTTTCTTTCAGACCCTGCCTACCTGCAGGCAGATGGACCGGAGGGTTT TCTGCTTCCTTTCAACCAGATAACTTCCTAAGTGGAGATGGCCTGTAGGTAGCAAATGCAGGATTTTGTTTACTTTCATCATGTCATGTG GTGGTCAGACTGCTCGCTGGTGGCCTCGCTTTAGAAGGTTTTCATCAAGCCCCGCCCTTTCTCTCTCATAGTCTTAATGCGTCTGGACCA CTGGGGAAAATATTTTTCTTTTCAAAAAGCAGCCCCTTCAGTCTGCGTTCCCAGTTCATTTTGCAGGCGCATTCGCCCTTCCTAGTTTGC AGCAATTAAAGATAACGGAGTGTAAAGTCATTAGACCCAGAATTAGAGCAGCCAGCAGCTGGCCCAGTGTAAAAATGTCCCAAGTGTAGC CCCTCCCACCGCAGAGCCTGTTTCTAACGTACCTGCCATTCGTGGAAGTCGCCTGGGTTTTGTAAAGGAGAATTTTTTGGACTCAAGCTG TCATCTTCAAGCACGCCAACTTCAGGCAGTGTTTTCTACTGCAAACCTCCACATCCTGGAATCAATCACACTGACAGGGAAAGGATAAAT GCTCCTTTATAAGCCAACATGTATCCAAATTAAGCCCCCTTACCTTTATCCAGACCCTTTCACAAACAAGTTCTGAGTTTTTAGCCAATT GATCCTCTACTTTCCTTCTTTAGTCCCTCTCAGGGACGCCTCCATCCCCGGCTCCCCTAAAGGTAGAAGATACTCGAGCATGCTGCCAGG GGAGCTGGATGGTGAAACACCTGAAGATCTCATATCGCCTCTCAAAACACTGTCGGACTTGCTTTCTGCTTTATGATGTCCGTAGTTGTT >60637_60637_2_NT5DC3-FBXW8_NT5DC3_chr12_104234727_ENST00000392876_FBXW8_chr12_117365828_ENST00000455858_length(amino acids)=490AA_BP=0 MNDVPFFDIQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLIFQECRAKEHMLRTNWKNR KGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRT GKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRRYPVAVAAAGDLMYLLKAEDSAR TLLYAHGPPVTCLDVSANQVAFGVQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDFTCVNLSDSPPNLMVSGNMDGRVRIHDLRSGNIA LSLSAHQLRVSAVQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLIRA -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for NT5DC3-FBXW8 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for NT5DC3-FBXW8 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for NT5DC3-FBXW8 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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