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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGAP31-CCDC37 (FusionGDB2 ID:6064)

Fusion Gene Summary for ARHGAP31-CCDC37

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP31-CCDC37
Fusion gene ID: 6064
HgeneTgene
Gene symbol

ARHGAP31

CCDC37

Gene ID

57514

348807

Gene nameRho GTPase activating protein 31cilia and flagella associated protein 100
SynonymsAOS1|CDGAPCCDC37|MIA1
Cytomap

3q13.32-q13.33

3q21.3

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 31Cdc42 GTPase-activating proteincilia- and flagella-associated protein 100coiled-coil domain containing 37coiled-coil domain-containing protein 37
Modification date2020031320200313
UniProtAcc

Q2M1Z3

.
Ensembl transtripts involved in fusion geneENST00000264245, ENST00000506204, 
ENST00000352312, ENST00000393425, 
ENST00000505024, ENST00000510833, 
Fusion gene scores* DoF score3 X 3 X 3=272 X 2 X 2=8
# samples 33
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/8*10)=1.90689059560852
Context

PubMed: ARHGAP31 [Title/Abstract] AND CCDC37 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP31(119013851)-CCDC37(126126015), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARHGAP31 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CCDC37 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-AB2V-01AARHGAP31chr3

119013851

+CCDC37chr3

126126015

+
ChimerDB4SARCTCGA-SI-A71Q-01AARHGAP31chr3

119013851

-CCDC37chr3

126126015

+


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Fusion Gene ORF analysis for ARHGAP31-CCDC37

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000264245ENST00000506204ARHGAP31chr3

119013851

+CCDC37chr3

126126015

+
In-frameENST00000264245ENST00000352312ARHGAP31chr3

119013851

+CCDC37chr3

126126015

+
In-frameENST00000264245ENST00000393425ARHGAP31chr3

119013851

+CCDC37chr3

126126015

+
In-frameENST00000264245ENST00000505024ARHGAP31chr3

119013851

+CCDC37chr3

126126015

+
In-frameENST00000264245ENST00000510833ARHGAP31chr3

119013851

+CCDC37chr3

126126015

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264245ARHGAP31chr3119013851+ENST00000393425CCDC37chr3126126015+25736325322421629
ENST00000264245ARHGAP31chr3119013851+ENST00000352312CCDC37chr3126126015+25706325322418628
ENST00000264245ARHGAP31chr3119013851+ENST00000510833CCDC37chr3126126015+972632532936134
ENST00000264245ARHGAP31chr3119013851+ENST00000505024CCDC37chr3126126015+25486325322421629

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264245ENST00000393425ARHGAP31chr3119013851+CCDC37chr3126126015+0.0251333320.9748667
ENST00000264245ENST00000352312ARHGAP31chr3119013851+CCDC37chr3126126015+0.027128730.9728713
ENST00000264245ENST00000510833ARHGAP31chr3119013851+CCDC37chr3126126015+0.0269131720.97308683
ENST00000264245ENST00000505024ARHGAP31chr3119013851+CCDC37chr3126126015+0.0264244020.97357565

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Fusion Genomic Features for ARHGAP31-CCDC37


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARHGAP31chr3119013851+CCDC37chr3126126014+0.058241140.9417589
ARHGAP31chr3119013851+CCDC37chr3126126014+0.058241140.9417589

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARHGAP31-CCDC37


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:119013851/chr3:126126015)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP31

Q2M1Z3

.
FUNCTION: Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCCDC37chr3:119013851chr3:126126015ENST00000352312117101_12816612.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC37chr3:119013851chr3:126126015ENST00000352312117164_20316612.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC37chr3:119013851chr3:126126015ENST00000352312117230_25716612.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC37chr3:119013851chr3:126126015ENST00000352312117393_43216612.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC37chr3:119013851chr3:126126015ENST00000352312117526_57816612.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC37chr3:119013851chr3:126126015ENST00000393425117101_12816613.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC37chr3:119013851chr3:126126015ENST00000393425117164_20316613.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC37chr3:119013851chr3:126126015ENST00000393425117230_25716613.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC37chr3:119013851chr3:126126015ENST00000393425117393_43216613.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC37chr3:119013851chr3:126126015ENST00000393425117526_57816613.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC37chr3:119013851chr3:126126015ENST00000505024016101_12816613.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC37chr3:119013851chr3:126126015ENST00000505024016164_20316613.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC37chr3:119013851chr3:126126015ENST00000505024016230_25716613.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC37chr3:119013851chr3:126126015ENST00000505024016393_43216613.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC37chr3:119013851chr3:126126015ENST00000505024016526_57816613.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP31chr3:119013851chr3:126126015ENST00000264245+112673_790331445.0Compositional biasNote=Pro-rich
HgeneARHGAP31chr3:119013851chr3:126126015ENST00000264245+112971_974331445.0Compositional biasNote=Poly-Ser
HgeneARHGAP31chr3:119013851chr3:126126015ENST00000264245+11221_216331445.0DomainRho-GAP


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Fusion Gene Sequence for ARHGAP31-CCDC37


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6064_6064_1_ARHGAP31-CCDC37_ARHGAP31_chr3_119013851_ENST00000264245_CCDC37_chr3_126126015_ENST00000352312_length(transcript)=2570nt_BP=632nt
GGAAAAAAAGGAAGGCGTGAGGGCGGGCAGCAGCGACAGGATGCTTGTTTTTCGCTCTACCAAAGTCGTCTGAAGGCGAGACAGCGGGCC
CAGGGCGCAGGACCCACCGCAGCCCCCTGGGCAGTCTCCTCGCCCCGCGTCCGCGTCGTCTCCGGGGCACTTAGTAAGGGGTGGGGAGAG
CTTGCCCTCCCTCTTAAGCTGAGGAGAAACACCCGAAGACACCGCAGGAGCCTGTGAAAGTCCCTAGGACTCCAAGTGAGGAAGTGACAC
TCCCAGGCGAGCCGGCCCGCGGCTGCCAGTCTGCACGGCCTCGGCACGGCGGCCCCGGAGCGGCGCGGGGTGGATCTCAGGCTCTGCCGG
CCCGCGGCCCGCGGGGTCCATGCGCAGGGCCCCCAGCCCAAGTTCTTCCATCTTCCGATGCGGCCCCCCAGAGCCGCGGGGCAGCCGGTG
ATCTAGCCCGGGAGCCCATCTTACAGCGGTGCCAAGCAGAGGGGCGGCAGAGACGGAGGGGCAGCCTCTTTGGGACTAACTCATGAAGAA
CAAGGGTGCTAAGCAGAAGCTGAAACGAAAGGGAGCCGCCAGCGCGTTTGGCTGTGACCTGACGGAGTATCTGGAAAGCTCGGGACAGGA
TGAGAACAGCCTGGAATCCATGAACATCAGCTCTTCTTCAAGCACTGAAGAGAACCCAAAGAAACAGGCAAGAAAAAACGAAGAACATGG
TCCTGACCCTTCAGCGAACCCTTTCCACTTATCTGGGGATGTGGATTTCTTCTTGCTCAGAGATCAGGAGCGGAATAAGGCTCTCTCCGA
ACGGCAGCAGCAGAAGACGATGCGGGTGCACCAGAAGATGACCTACTCCTCGAAAGTGTCGGCTAAGCACACCAGCCTGCGGCGGCAGCT
GCAGCTGGAGGACAAGCAGGAGGACCTGGAGGCGCGCGCCGAGGCCGAGCATCAGCGCGCCTTCCGCGACTACACGACCTGGAAGCTCAC
CTTGACCAAAGAAAAGAATGTGGAGCCTGAGAACATGAGTGGCTACATTAAGCAGAAGCGGCAAATGTTCCTCCTCCAGTATGCCCTGGA
TGTCAAGCGGAGAGAGATCCAGCGGCTGGAGACGCTGGCGACCAAAGAGGAGGCCAGGCTGGAGCGGGCCGAGAAATCCCTGGAGAAGGA
CGCCGCCTTGTTCGACGAGTTCGTCAGGGAGAATGACTGCAGCTCCGTGCAGGCCATGAGAGCGGCTGAGAAGGAGACCAAAGCCAAGAT
AGAGAAGATCCTTGAGATCCGGGACCTCACCACCCAGATTGTTAATATCAAAAGTGAGATCTCCAGATTTGAAGACACTCTGAAGCATTA
CAAGGTCTATAAGGATTTCCTATACAAGCTGTCGCCCAAGGAGTGGCTTGAAGAACAGGAAAAGAAACACTCGTTTCTCAAAAAGGCCAA
GGAGGTCTCCGAGGCTTCCAAAGAGAGCAGTGTTAACTCCACACCAGGGGACAAAGGACCAGGGATCAAGGGCAAGGCGAGCTCCATGTG
GGCCAAAGAGGGTCAGGGTACAAAGAAGCCCTGGAGGTTTCTGCAGACGATGCGGCTGGGGCGGAGCCCGTCTTACCTGAGCAGCCCCCA
GCAAGGCAGCCAGCCCAGCGAGTCCAGCGGTGGCGACTCCAGAGGGTCGAACTCTCCCATCCCCCCCACGCAGGAGGACACCGACAGCGA
TGGGGAGGAACCACAGCTGTACTTCACGGAGCCCCAGCAGCTCCTGGATGTCTTCCGAGAGCTGGAGGAGCAGAACCTGTCGCTGATCCA
GAACAGCCAGGAGACGGAGAAGACCCTGGAGGAGCTGAGCCACACCCTGAAACACACCCAGATCCGCATGGACAGGGAGGTCAACCAGCT
GAAGCAGTGGGTCACCACAATGATGATGTCCATCACCAAGGAGGAGGACACAGCAGCTGAGCTGGAGCTCAAAGCCCGAGTCTTCCACTT
CGGCGAGTACAAGGGCGATCAGCAGGATAAGCTGCTAGAGAGCCTGAACTGCAAGGTGCTGGATGTGTACCGGCACTGCACCGGCACCCA
GCAGGAGGCCAACCTGGGCACCGTGCAGATGCTGACCATCATTGAGCACCAGCTGGATGAGCTGCTAGAGAACCTGGAGCACGTGCCCCA
GGTCAAGATCGAGCAGGCCGAGAGGGCAAAGGAGAAGGAGCGGCGCATCAGACTTCGAGAAGAGAAGCTCCAGATGCAAAAGATCCTACA
GGAGGAGCATCTGCAGCGGGCCCGGGCGCGCGCCCAGGCTGAGATCAAGAAGAAGAGAGGCAGGACACTGGTATGCCGCTCACGACCCCC
AGCCCACAGGATCAAACAACAGTCTGAGCACACACTGATGGACAAGGAGGAGGAGGAGCTGCTATTTTTCTTTACTTAATCTTCGCAGAC
CATAGCTGTTCTGGCTGAAGGCTTAGCAAAGATGTTGGCAGAGGAAGCAGAGACTGGGCTGGGTCTCGAGTGGCCCAACTGAGTCCTCTC

>6064_6064_1_ARHGAP31-CCDC37_ARHGAP31_chr3_119013851_ENST00000264245_CCDC37_chr3_126126015_ENST00000352312_length(amino acids)=628AA_BP=33
MKNKGAKQKLKRKGAASAFGCDLTEYLESSGQDENSLESMNISSSSSTEENPKKQARKNEEHGPDPSANPFHLSGDVDFFLLRDQERNKA
LSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQY
ALDVKRREIQRLETLATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVNIKSEISRFEDTL
KHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLS
SPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDREV
NQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEH

--------------------------------------------------------------
>6064_6064_2_ARHGAP31-CCDC37_ARHGAP31_chr3_119013851_ENST00000264245_CCDC37_chr3_126126015_ENST00000393425_length(transcript)=2573nt_BP=632nt
GGAAAAAAAGGAAGGCGTGAGGGCGGGCAGCAGCGACAGGATGCTTGTTTTTCGCTCTACCAAAGTCGTCTGAAGGCGAGACAGCGGGCC
CAGGGCGCAGGACCCACCGCAGCCCCCTGGGCAGTCTCCTCGCCCCGCGTCCGCGTCGTCTCCGGGGCACTTAGTAAGGGGTGGGGAGAG
CTTGCCCTCCCTCTTAAGCTGAGGAGAAACACCCGAAGACACCGCAGGAGCCTGTGAAAGTCCCTAGGACTCCAAGTGAGGAAGTGACAC
TCCCAGGCGAGCCGGCCCGCGGCTGCCAGTCTGCACGGCCTCGGCACGGCGGCCCCGGAGCGGCGCGGGGTGGATCTCAGGCTCTGCCGG
CCCGCGGCCCGCGGGGTCCATGCGCAGGGCCCCCAGCCCAAGTTCTTCCATCTTCCGATGCGGCCCCCCAGAGCCGCGGGGCAGCCGGTG
ATCTAGCCCGGGAGCCCATCTTACAGCGGTGCCAAGCAGAGGGGCGGCAGAGACGGAGGGGCAGCCTCTTTGGGACTAACTCATGAAGAA
CAAGGGTGCTAAGCAGAAGCTGAAACGAAAGGGAGCCGCCAGCGCGTTTGGCTGTGACCTGACGGAGTATCTGGAAAGCTCGGGACAGGA
TGAGAACAGCCTGGAATCCATGAACATCAGCTCTTCTTCAAGCACTGAAGAGAACCCAAAGAAACAGGCAAGAAAAAACGAAGAACATGG
TCCTGACCCTTCAGCGAACCCTTTCCACTTATCTGGGGATGTGGATTTCTTCTTGCTCAGAGATCAGGAGCGGAATAAGGCTCTCTCCGA
ACGGCAGCAGCAGAAGACGATGCGGGTGCACCAGAAGATGACCTACTCCTCGAAAGTGTCGGCTAAGCACACCAGCCTGCGGCGGCAGCT
GCAGCTGGAGGACAAGCAGGAGGACCTGGAGGCGCGCGCCGAGGCCGAGCATCAGCGCGCCTTCCGCGACTACACGACCTGGAAGCTCAC
CTTGACCAAAGCAGAAAAGAATGTGGAGCCTGAGAACATGAGTGGCTACATTAAGCAGAAGCGGCAAATGTTCCTCCTCCAGTATGCCCT
GGATGTCAAGCGGAGAGAGATCCAGCGGCTGGAGACGCTGGCGACCAAAGAGGAGGCCAGGCTGGAGCGGGCCGAGAAATCCCTGGAGAA
GGACGCCGCCTTGTTCGACGAGTTCGTCAGGGAGAATGACTGCAGCTCCGTGCAGGCCATGAGAGCGGCTGAGAAGGAGACCAAAGCCAA
GATAGAGAAGATCCTTGAGATCCGGGACCTCACCACCCAGATTGTTAATATCAAAAGTGAGATCTCCAGATTTGAAGACACTCTGAAGCA
TTACAAGGTCTATAAGGATTTCCTATACAAGCTGTCGCCCAAGGAGTGGCTTGAAGAACAGGAAAAGAAACACTCGTTTCTCAAAAAGGC
CAAGGAGGTCTCCGAGGCTTCCAAAGAGAGCAGTGTTAACTCCACACCAGGGGACAAAGGACCAGGGATCAAGGGCAAGGCGAGCTCCAT
GTGGGCCAAAGAGGGTCAGGGTACAAAGAAGCCCTGGAGGTTTCTGCAGACGATGCGGCTGGGGCGGAGCCCGTCTTACCTGAGCAGCCC
CCAGCAAGGCAGCCAGCCCAGCGAGTCCAGCGGTGGCGACTCCAGAGGGTCGAACTCTCCCATCCCCCCCACGCAGGAGGACACCGACAG
CGATGGGGAGGAACCACAGCTGTACTTCACGGAGCCCCAGCAGCTCCTGGATGTCTTCCGAGAGCTGGAGGAGCAGAACCTGTCGCTGAT
CCAGAACAGCCAGGAGACGGAGAAGACCCTGGAGGAGCTGAGCCACACCCTGAAACACACCCAGATCCGCATGGACAGGGAGGTCAACCA
GCTGAAGCAGTGGGTCACCACAATGATGATGTCCATCACCAAGGAGGAGGACACAGCAGCTGAGCTGGAGCTCAAAGCCCGAGTCTTCCA
CTTCGGCGAGTACAAGGGCGATCAGCAGGATAAGCTGCTAGAGAGCCTGAACTGCAAGGTGCTGGATGTGTACCGGCACTGCACCGGCAC
CCAGCAGGAGGCCAACCTGGGCACCGTGCAGATGCTGACCATCATTGAGCACCAGCTGGATGAGCTGCTAGAGAACCTGGAGCACGTGCC
CCAGGTCAAGATCGAGCAGGCCGAGAGGGCAAAGGAGAAGGAGCGGCGCATCAGACTTCGAGAAGAGAAGCTCCAGATGCAAAAGATCCT
ACAGGAGGAGCATCTGCAGCGGGCCCGGGCGCGCGCCCAGGCTGAGATCAAGAAGAAGAGAGGCAGGACACTGGTATGCCGCTCACGACC
CCCAGCCCACAGGATCAAACAACAGTCTGAGCACACACTGATGGACAAGGAGGAGGAGGAGCTGCTATTTTTCTTTACTTAATCTTCGCA
GACCATAGCTGTTCTGGCTGAAGGCTTAGCAAAGATGTTGGCAGAGGAAGCAGAGACTGGGCTGGGTCTCGAGTGGCCCAACTGAGTCCT

>6064_6064_2_ARHGAP31-CCDC37_ARHGAP31_chr3_119013851_ENST00000264245_CCDC37_chr3_126126015_ENST00000393425_length(amino acids)=629AA_BP=33
MKNKGAKQKLKRKGAASAFGCDLTEYLESSGQDENSLESMNISSSSSTEENPKKQARKNEEHGPDPSANPFHLSGDVDFFLLRDQERNKA
LSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRAFRDYTTWKLTLTKAEKNVEPENMSGYIKQKRQMFLLQ
YALDVKRREIQRLETLATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVNIKSEISRFEDT
LKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYL
SSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDRE
VNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLE

--------------------------------------------------------------
>6064_6064_3_ARHGAP31-CCDC37_ARHGAP31_chr3_119013851_ENST00000264245_CCDC37_chr3_126126015_ENST00000505024_length(transcript)=2548nt_BP=632nt
GGAAAAAAAGGAAGGCGTGAGGGCGGGCAGCAGCGACAGGATGCTTGTTTTTCGCTCTACCAAAGTCGTCTGAAGGCGAGACAGCGGGCC
CAGGGCGCAGGACCCACCGCAGCCCCCTGGGCAGTCTCCTCGCCCCGCGTCCGCGTCGTCTCCGGGGCACTTAGTAAGGGGTGGGGAGAG
CTTGCCCTCCCTCTTAAGCTGAGGAGAAACACCCGAAGACACCGCAGGAGCCTGTGAAAGTCCCTAGGACTCCAAGTGAGGAAGTGACAC
TCCCAGGCGAGCCGGCCCGCGGCTGCCAGTCTGCACGGCCTCGGCACGGCGGCCCCGGAGCGGCGCGGGGTGGATCTCAGGCTCTGCCGG
CCCGCGGCCCGCGGGGTCCATGCGCAGGGCCCCCAGCCCAAGTTCTTCCATCTTCCGATGCGGCCCCCCAGAGCCGCGGGGCAGCCGGTG
ATCTAGCCCGGGAGCCCATCTTACAGCGGTGCCAAGCAGAGGGGCGGCAGAGACGGAGGGGCAGCCTCTTTGGGACTAACTCATGAAGAA
CAAGGGTGCTAAGCAGAAGCTGAAACGAAAGGGAGCCGCCAGCGCGTTTGGCTGTGACCTGACGGAGTATCTGGAAAGCTCGGGACAGGA
TGAGAACAGCCTGGAATCCATGAACATCAGCTCTTCTTCAAGCACTGAAGAGAACCCAAAGAAACAGGCAAGAAAAAACGAAGAACATGG
TCCTGACCCTTCAGCGAACCCTTTCCACTTATCTGGGGATGTGGATTTCTTCTTGCTCAGAGATCAGGAGCGGAATAAGGCTCTCTCCGA
ACGGCAGCAGCAGAAGACGATGCGGGTGCACCAGAAGATGACCTACTCCTCGAAAGTGTCGGCTAAGCACACCAGCCTGCGGCGGCAGCT
GCAGCTGGAGGACAAGCAGGAGGACCTGGAGGCGCGCGCCGAGGCCGAGCATCAGCGCGCCTTCCGCGACTACACGACCTGGAAGCTCAC
CTTGACCAAAGCAGAAAAGAATGTGGAGCCTGAGAACATGAGTGGCTACATTAAGCAGAAGCGGCAAATGTTCCTCCTCCAGTATGCCCT
GGATGTCAAGCGGAGAGAGATCCAGCGGCTGGAGACGCTGGCGACCAAAGAGGAGGCCAGGCTGGAGCGGGCCGAGAAATCCCTGGAGAA
GGACGCCGCCTTGTTCGACGAGTTCGTCAGGGAGAATGACTGCAGCTCCGTGCAGGCCATGAGAGCGGCTGAGAAGGAGACCAAAGCCAA
GATAGAGAAGATCCTTGAGATCCGGGACCTCACCACCCAGATTGTTAATATCAAAAGTGAGATCTCCAGATTTGAAGACACTCTGAAGCA
TTACAAGGTCTATAAGGATTTCCTATACAAGCTGTCGCCCAAGGAGTGGCTTGAAGAACAGGAAAAGAAACACTCGTTTCTCAAAAAGGC
CAAGGAGGTCTCCGAGGCTTCCAAAGAGAGCAGTGTTAACTCCACACCAGGGGACAAAGGACCAGGGATCAAGGGCAAGGCGAGCTCCAT
GTGGGCCAAAGAGGGTCAGGGTACAAAGAAGCCCTGGAGGTTTCTGCAGACGATGCGGCTGGGGCGGAGCCCGTCTTACCTGAGCAGCCC
CCAGCAAGGCAGCCAGCCCAGCGAGTCCAGCGGTGGCGACTCCAGAGGGTCGAACTCTCCCATCCCCCCCACGCAGGAGGACACCGACAG
CGATGGGGAGGAACCACAGCTGTACTTCACGGAGCCCCAGCAGCTCCTGGATGTCTTCCGAGAGCTGGAGGAGCAGAACCTGTCGCTGAT
CCAGAACAGCCAGGAGACGGAGAAGACCCTGGAGGAGCTGAGCCACACCCTGAAACACACCCAGATCCGCATGGACAGGGAGGTCAACCA
GCTGAAGCAGTGGGTCACCACAATGATGATGTCCATCACCAAGGAGGAGGACACAGCAGCTGAGCTGGAGCTCAAAGCCCGAGTCTTCCA
CTTCGGCGAGTACAAGGGCGATCAGCAGGATAAGCTGCTAGAGAGCCTGAACTGCAAGGTGCTGGATGTGTACCGGCACTGCACCGGCAC
CCAGCAGGAGGCCAACCTGGGCACCGTGCAGATGCTGACCATCATTGAGCACCAGCTGGATGAGCTGCTAGAGAACCTGGAGCACGTGCC
CCAGGTCAAGATCGAGCAGGCCGAGAGGGCAAAGGAGAAGGAGCGGCGCATCAGACTTCGAGAAGAGAAGCTCCAGATGCAAAAGATCCT
ACAGGAGGAGCATCTGCAGCGGGCCCGGGCGCGCGCCCAGGCTGAGATCAAGAAGAAGAGAGGCAGGACACTGGTATGCCGCTCACGACC
CCCAGCCCACAGGATCAAACAACAGTCTGAGCACACACTGATGGACAAGGAGGAGGAGGAGCTGCTATTTTTCTTTACTTAATCTTCGCA
GACCATAGCTGTTCTGGCTGAAGGCTTAGCAAAGATGTTGGCAGAGGAAGCAGAGACTGGGCTGGGTCTCGAGTGGCCCAACTGAGTCCT

>6064_6064_3_ARHGAP31-CCDC37_ARHGAP31_chr3_119013851_ENST00000264245_CCDC37_chr3_126126015_ENST00000505024_length(amino acids)=629AA_BP=33
MKNKGAKQKLKRKGAASAFGCDLTEYLESSGQDENSLESMNISSSSSTEENPKKQARKNEEHGPDPSANPFHLSGDVDFFLLRDQERNKA
LSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRAFRDYTTWKLTLTKAEKNVEPENMSGYIKQKRQMFLLQ
YALDVKRREIQRLETLATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVNIKSEISRFEDT
LKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYL
SSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDRE
VNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLE

--------------------------------------------------------------
>6064_6064_4_ARHGAP31-CCDC37_ARHGAP31_chr3_119013851_ENST00000264245_CCDC37_chr3_126126015_ENST00000510833_length(transcript)=972nt_BP=632nt
GGAAAAAAAGGAAGGCGTGAGGGCGGGCAGCAGCGACAGGATGCTTGTTTTTCGCTCTACCAAAGTCGTCTGAAGGCGAGACAGCGGGCC
CAGGGCGCAGGACCCACCGCAGCCCCCTGGGCAGTCTCCTCGCCCCGCGTCCGCGTCGTCTCCGGGGCACTTAGTAAGGGGTGGGGAGAG
CTTGCCCTCCCTCTTAAGCTGAGGAGAAACACCCGAAGACACCGCAGGAGCCTGTGAAAGTCCCTAGGACTCCAAGTGAGGAAGTGACAC
TCCCAGGCGAGCCGGCCCGCGGCTGCCAGTCTGCACGGCCTCGGCACGGCGGCCCCGGAGCGGCGCGGGGTGGATCTCAGGCTCTGCCGG
CCCGCGGCCCGCGGGGTCCATGCGCAGGGCCCCCAGCCCAAGTTCTTCCATCTTCCGATGCGGCCCCCCAGAGCCGCGGGGCAGCCGGTG
ATCTAGCCCGGGAGCCCATCTTACAGCGGTGCCAAGCAGAGGGGCGGCAGAGACGGAGGGGCAGCCTCTTTGGGACTAACTCATGAAGAA
CAAGGGTGCTAAGCAGAAGCTGAAACGAAAGGGAGCCGCCAGCGCGTTTGGCTGTGACCTGACGGAGTATCTGGAAAGCTCGGGACAGGA
TGAGAACAGCCTGGAATCCATGAACATCAGCTCTTCTTCAAGCACTGAAGAGAACCCAAAGAAACAGGCAAGAAAAAACGAAGAACATGG
TCCTGACCCTTCAGCGAACCCTTTCCACTTATCTGGGGATGTGGATTTCTTCTTGCTCAGAGATCAGGAGCGGAATAAGGCTCTCTCCGT
GAGTATCCAGGACAGACGCCAGCACCTCCGGGAGCTTCCCTGCTCCCACTGCTTCCTGGAGTGGCCACATTGCCCTTCTCAGAGGAGCAC

>6064_6064_4_ARHGAP31-CCDC37_ARHGAP31_chr3_119013851_ENST00000264245_CCDC37_chr3_126126015_ENST00000510833_length(amino acids)=134AA_BP=33
MKNKGAKQKLKRKGAASAFGCDLTEYLESSGQDENSLESMNISSSSSTEENPKKQARKNEEHGPDPSANPFHLSGDVDFFLLRDQERNKA

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Fusion Gene PPI Analysis for ARHGAP31-CCDC37


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGAP31-CCDC37


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGAP31-CCDC37


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource