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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NT5E-ASCC3 (FusionGDB2 ID:60642)

Fusion Gene Summary for NT5E-ASCC3

Fusion gene summary

Fusion gene information	Fusion gene name: NT5E-ASCC3
	Fusion gene ID: 60642
		Hgene	Tgene
	Gene symbol	NT5E	ASCC3
	Gene ID	4907	10973
	Gene name	5'-nucleotidase ecto	activating signal cointegrator 1 complex subunit 3
	Synonyms	CALJA\|CD73\|E5NT\|NT\|NT5\|NTE\|eN\|eNT	ASC1p200\|HELIC1\|RNAH
	Cytomap	6q14.3	6q16.3
	Type of gene	protein-coding	protein-coding
	Description	5'-nucleotidase5'-NTPurine 5-Prime-Nucleotidaseecto-5'-nucleotidase	activating signal cointegrator 1 complex subunit 3ASC-1 complex subunit P200RNA helicase familyhelicase, ATP binding 1trip4 complex subunit p200
	Modification date	20200329	20200313
	UniProtAcc	.	Q8N3C0
	Ensembl transtripts involved in fusion gene	ENST00000257770, ENST00000369646, ENST00000369651,	ENST00000369143, ENST00000522650, ENST00000369162,
Fusion gene scores	* DoF score	4 X 3 X 3=36	14 X 10 X 11=1540
	# samples	4	18
	** MAII score	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(18/1540*10)=-3.09686153925259 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NT5E [Title/Abstract] AND ASCC3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NT5E(86160196)-ASCC3(101054964), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NT5E	GO:0007159	leukocyte cell-cell adhesion	7595232
Tgene	ASCC3	GO:0006307	DNA dealkylation involved in DNA repair	22055184
Tgene	ASCC3	GO:0032508	DNA duplex unwinding	22055184

Fusion gene breakpoints across NT5E (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ASCC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-CC-A8HV-01A	NT5E	chr6	86160196	-	ASCC3	chr6	101054964	-

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Fusion Gene ORF analysis for NT5E-ASCC3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000257770	ENST00000369143	NT5E	chr6	86160196	-	ASCC3	chr6	101054964	-
5CDS-intron	ENST00000257770	ENST00000522650	NT5E	chr6	86160196	-	ASCC3	chr6	101054964	-
5CDS-intron	ENST00000369646	ENST00000369143	NT5E	chr6	86160196	-	ASCC3	chr6	101054964	-
5CDS-intron	ENST00000369646	ENST00000522650	NT5E	chr6	86160196	-	ASCC3	chr6	101054964	-
5CDS-intron	ENST00000369651	ENST00000369143	NT5E	chr6	86160196	-	ASCC3	chr6	101054964	-
5CDS-intron	ENST00000369651	ENST00000522650	NT5E	chr6	86160196	-	ASCC3	chr6	101054964	-
In-frame	ENST00000257770	ENST00000369162	NT5E	chr6	86160196	-	ASCC3	chr6	101054964	-
In-frame	ENST00000369646	ENST00000369162	NT5E	chr6	86160196	-	ASCC3	chr6	101054964	-
In-frame	ENST00000369651	ENST00000369162	NT5E	chr6	86160196	-	ASCC3	chr6	101054964	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000369646	NT5E	chr6	86160196	-	ENST00000369162	ASCC3	chr6	101054964	-	3404	388	49	2211	720
ENST00000257770	NT5E	chr6	86160196	-	ENST00000369162	ASCC3	chr6	101054964	-	3404	388	49	2211	720
ENST00000369651	NT5E	chr6	86160196	-	ENST00000369162	ASCC3	chr6	101054964	-	3386	370	31	2193	720

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000369646	ENST00000369162	NT5E	chr6	86160196	-	ASCC3	chr6	101054964	-	0.000386139	0.99961394
ENST00000257770	ENST00000369162	NT5E	chr6	86160196	-	ASCC3	chr6	101054964	-	0.000386139	0.99961394
ENST00000369651	ENST00000369162	NT5E	chr6	86160196	-	ASCC3	chr6	101054964	-	0.000377277	0.9996227

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Fusion Genomic Features for NT5E-ASCC3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NT5E-ASCC3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:86160196/chr6:101054964)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ASCC3 Q8N3C0
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions (PubMed:22055184). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). {ECO:0000269\|PubMed:12077347, ECO:0000269\|PubMed:22055184}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000369143

18_79

112.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000369143

328_356

112.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000522650

18_79

732.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000522650

328_356

732.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000369143

1336_1511

112.0

Domain

Helicase ATP-binding 2

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000369143

1544_1739

112.0

Domain

Helicase C-terminal 2

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000369143

1812_2176

112.0

Domain

Note=SEC63 2

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000369143

486_669

112.0

Domain

Helicase ATP-binding 1

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000369143

728_914

112.0

Domain

Helicase C-terminal 1

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000369143

978_1287

112.0

Domain

Note=SEC63 1

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000369162

1812_2176

1595

2203.0

Domain

Note=SEC63 2

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000522650

1336_1511

732.0

Domain

Helicase ATP-binding 2

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000522650

1544_1739

732.0

Domain

Helicase C-terminal 2

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000522650

1812_2176

732.0

Domain

Note=SEC63 2

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000522650

486_669

732.0

Domain

Helicase ATP-binding 1

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000522650

728_914

732.0

Domain

Helicase C-terminal 1

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000522650

978_1287

732.0

Domain

Note=SEC63 1

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000369143

1453_1456

112.0

Motif

Note=DEIH box

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000369143

611_614

112.0

Motif

Note=DEVH box

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000522650

1453_1456

732.0

Motif

Note=DEIH box

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000522650

611_614

732.0

Motif

Note=DEVH box

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000369143

1349_1356

112.0

Nucleotide binding

ATP

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000369143

499_506

112.0

Nucleotide binding

ATP

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000522650

1349_1356

732.0

Nucleotide binding

ATP

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000522650

499_506

732.0

Nucleotide binding

ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NT5E

chr6:86160196

chr6:101054964

ENST00000257770

500_506

113

575.0

Region

Substrate binding

Hgene

NT5E

chr6:86160196

chr6:101054964

ENST00000369651

500_506

113

525.0

Region

Substrate binding

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000369162

18_79

1595

2203.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000369162

328_356

1595

2203.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000369162

1336_1511

1595

2203.0

Domain

Helicase ATP-binding 2

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000369162

1544_1739

1595

2203.0

Domain

Helicase C-terminal 2

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000369162

486_669

1595

2203.0

Domain

Helicase ATP-binding 1

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000369162

728_914

1595

2203.0

Domain

Helicase C-terminal 1

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000369162

978_1287

1595

2203.0

Domain

Note=SEC63 1

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000369162

1453_1456

1595

2203.0

Motif

Note=DEIH box

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000369162

611_614

1595

2203.0

Motif

Note=DEVH box

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000369162

1349_1356

1595

2203.0

Nucleotide binding

ATP

Tgene

ASCC3

chr6:86160196

chr6:101054964

ENST00000369162

499_506

1595

2203.0

Nucleotide binding

ATP

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Fusion Gene Sequence for NT5E-ASCC3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>60642_60642_1_NT5E-ASCC3_NT5E_chr6_86160196_ENST00000257770_ASCC3_chr6_101054964_ENST00000369162_length(transcript)=3404nt_BP=388nt
GCACTCGCCCGGCTCGCCCGCTTTCGCACCCAGTTCACGCGCCACAGCTATGTGTCCCCGAGCCGCGCGGGCGCCCGCGACGCTACTCCT
CGCCCTGGGCGCGGTGCTGTGGCCTGCGGCTGGCGCCTGGGAGCTTACGATTTTGCACACCAACGACGTGCACAGCCGGCTGGAGCAGAC
CAGCGAGGACTCCAGCAAGTGCGTCAACGCCAGCCGCTGCATGGGTGGCGTGGCTCGGCTCTTCACCAAGGTTCAGCAGATCCGCCGCGC
CGAACCCAACGTGCTGCTGCTGGACGCCGGCGACCAGTACCAGGGCACTATCTGGTTCACCGTGTACAAGGGCGCCGAGGTGGCGCACTT
CATGAACGCCCTGCGCTACGATGCCATGATGGAGAACATCATTGCAACAGTAAGAGATTCCAACCTCAAGCTGACCCTTGCTTTCGGGAT
AGGAATGCATCATGCTGGACTACATGAGAGGGACCGAAAAACAGTAGAGGAACTATTTGTAAACTGTAAAGTTCAGGTTCTTATTGCTAC
AAGCACATTAGCCTGGGGTGTAAACTTTCCAGCTCATTTAGTAATTATTAAGGGAACAGAATACTATGATGGAAAAACAAGACGTTATGT
GGATTTTCCCATTACAGATGTCCTCCAGATGATGGGGCGTGCTGGGAGGCCGCAGTTCGATGACCAAGGCAAAGCTGTAATTCTAGTTCA
TGACATAAAGAAAGACTTTTATAAAAAATTTCTTTATGAACCTTTCCCAGTAGAATCAAGTTTATTAGGAGTGCTCTCTGACCACTTAAA
TGCAGAGATTGCTGGTGGTACAATTACATCTAAGCAAGATGCATTGGATTATATCACCTGGACTTACTTTTTCCGACGTCTTATCATGAA
TCCCAGCTATTACAATTTGGGTGATGTGAGCCATGATTCTGTGAACAAGTTTCTGTCCCATCTGATTGAGAAGTCCCTGATTGAATTGGA
ACTTTCCTACTGTATTGAAATTGGAGAGGATAATCGCAGCATTGAACCTCTAACTTATGGCCGAATTGCCTCCTATTACTATTTGAAGCA
TCAAACAGTTAAAATGTTCAAGGACCGCTTGAAGCCTGAATGCAGTACTGAAGAACTGCTTTCAATTCTAAGTGATGCAGAAGAATATAC
AGATTTGCCAGTGAGACACAATGAAGATCATATGAATAGTGAACTGGCAAAATGTCTTCCCATTGAATCAAATCCTCATTCATTTGACAG
CCCTCACACCAAAGCACATCTCCTGCTACAGGCACATCTCAGCCGAGCCATGCTACCCTGCCCAGATTATGACACTGATACCAAAACAGT
CTTGGACCAAGCTCTCAGAGTATGTCAGGCAATGCTGGACGTGGCTGCAAACCAGGGCTGGCTGGTGACTGTCCTGAATATCACCAACCT
GATTCAGATGGTGATCCAGGGTCGGTGGTTAAAGGACTCTTCTCTTCTTACACTACCAAACATAGAAAACCATCATCTTCACCTTTTCAA
GAAATGGAAGCCGATTATGAAGGGCCCACATGCTAGGGGTCGGACCTCCATCGAGTCCCTTCCTGAACTGATCCATGCCTGTGGAGGGAA
AGACCATGTATTTAGCTCCATGGTAGAAAGTGAGCTACATGCTGCAAAAACGAAACAGGCATGGAATTTCTTATCTCACTTGCCAGTGAT
AAATGTTGGCATAAGTGTTAAAGGCTCGTGGGATGACTTAGTTGAAGGACATAATGAACTCTCTGTCTCAACTCTGACTGCAGACAAACG
AGATGACAACAAATGGATCAAATTGCATGCTGACCAAGAGTATGTGCTTCAAGTGAGCTTGCAGAGAGTCCACTTTGGGTTCCACAAGGG
AAAGCCAGAGAGCTGTGCAGTTACTCCTCGATTTCCCAAATCAAAAGACGAAGGATGGTTTTTGATATTAGGAGAAGTGGATAAGAGAGA
ACTTATTGCTTTGAAAAGAGTAGGATATATTCGAAATCATCATGTTGCTTCCCTTTCTTTTTATACCCCTGAAATACCTGGAAGGTATAT
CTACACATTATATTTCATGAGTGACTGCTACCTTGGCCTGGACCAGCAGTATGACATCTATCTCAACGTTACACAAGCGAGTCTTTCTGC
ACAGGTCAACACCAAGGTCTCTGATTCCCTGACTGACCTGGCATTAAAGTAACTTGACCTGAACAATCCATTTGAAAGGAGTGGCTAAGA
ATTCTCTCTGTTCAGTCATCTAGACAAATCGAATTACTTGATGTTTGCCTTGAAAGAATCAACTTCTAACCTCAACCATCCAGGAAATTG
ACAGTGGCTGCAGTATTGACTCCAGTGACATAAAGTTAACCACAGTGGCCTTTTAACAAATGTTGCCTTTTATAATGTTATCTTTATGAG
TTTCTTGATATGTAAGATGAAAAAGCATTTAGAATAATCTTTTAATTTGTGTATATTTGGGATGATATTTAGGAGCTATCAATCAAATTT
TACATCTCACAATGTACTGTTTACATGGATATTGGCTGCTTTTTTTAAGGAAAACCACATTGAGATGTGACAAGTGTTAGGACTTGTCAC
AGATTTCTAACTCTGCCGCATAAACTATAAATCTGTAAGGTGGTACACAGCGTGTCTTGTTAGCAAAATTTATACTTTGATATGATCACA
TGTAGAAGTAGCTTCAAGAATTTCTTGTAGTCATAAATGTTTAATAATATATGATGTAAAATTATATTATGGAGCCTAATGATGATAACA
AAGAAAACAATATACTGATCTTAGAAAATGTAGACATGGTTAACTGGGAAATAAAATATAGAGTGGCACTTCAAGACAAGCTGACTCAAT
GTTTTCTTCTGCTTCCTTTAAATAATATCCCCTTACTCATCTGTTCTTCTTTTCTTTCCCTTCTACTTCAAGGCTTTATTTCTATTATCT
TTCTGACATATTTATTTACAGAAGTAGAGAAGTATAATCTAATTCATGTTGTAGCACTTACAGATCATATAGTACAATTATTTGTCTTTA
TGCTCTCCAGGAAAAATCTGAGACAGAAAATTTTTCACCCCTATGGATAGGTTTTCACCTGTAATAAAGAAAATTTCTCTATGTCCAAAC
AAATTCCTTCTTGAAAAATACTTTTTCAAACTAAAAACTTGTTAAAATTCAATGTTCATATAATATGCATTCTAGTGGAATGAAATTCTA
CCTTTGTGAAATAATTTCAGTTTTCTTAGCCCTAAAATGAATTATTTTAAAACATTTTCCAATGTCATTGTTACAAATACTAGAATTTAA

>60642_60642_1_NT5E-ASCC3_NT5E_chr6_86160196_ENST00000257770_ASCC3_chr6_101054964_ENST00000369162_length(amino acids)=720AA_BP=113
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGT
IWFTVYKGAEVAHFMNALRYDAMMENIIATVRDSNLKLTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVII
KGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVILVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEIAGGTITSKQDALD
YITWTYFFRRLIMNPSYYNLGDVSHDSVNKFLSHLIEKSLIELELSYCIEIGEDNRSIEPLTYGRIASYYYLKHQTVKMFKDRLKPECST
EELLSILSDAEEYTDLPVRHNEDHMNSELAKCLPIESNPHSFDSPHTKAHLLLQAHLSRAMLPCPDYDTDTKTVLDQALRVCQAMLDVAA
NQGWLVTVLNITNLIQMVIQGRWLKDSSLLTLPNIENHHLHLFKKWKPIMKGPHARGRTSIESLPELIHACGGKDHVFSSMVESELHAAK
TKQAWNFLSHLPVINVGISVKGSWDDLVEGHNELSVSTLTADKRDDNKWIKLHADQEYVLQVSLQRVHFGFHKGKPESCAVTPRFPKSKD
EGWFLILGEVDKRELIALKRVGYIRNHHVASLSFYTPEIPGRYIYTLYFMSDCYLGLDQQYDIYLNVTQASLSAQVNTKVSDSLTDLALK

--------------------------------------------------------------
>60642_60642_2_NT5E-ASCC3_NT5E_chr6_86160196_ENST00000369646_ASCC3_chr6_101054964_ENST00000369162_length(transcript)=3404nt_BP=388nt
GCACTCGCCCGGCTCGCCCGCTTTCGCACCCAGTTCACGCGCCACAGCTATGTGTCCCCGAGCCGCGCGGGCGCCCGCGACGCTACTCCT
CGCCCTGGGCGCGGTGCTGTGGCCTGCGGCTGGCGCCTGGGAGCTTACGATTTTGCACACCAACGACGTGCACAGCCGGCTGGAGCAGAC
CAGCGAGGACTCCAGCAAGTGCGTCAACGCCAGCCGCTGCATGGGTGGCGTGGCTCGGCTCTTCACCAAGGTTCAGCAGATCCGCCGCGC
CGAACCCAACGTGCTGCTGCTGGACGCCGGCGACCAGTACCAGGGCACTATCTGGTTCACCGTGTACAAGGGCGCCGAGGTGGCGCACTT
CATGAACGCCCTGCGCTACGATGCCATGATGGAGAACATCATTGCAACAGTAAGAGATTCCAACCTCAAGCTGACCCTTGCTTTCGGGAT
AGGAATGCATCATGCTGGACTACATGAGAGGGACCGAAAAACAGTAGAGGAACTATTTGTAAACTGTAAAGTTCAGGTTCTTATTGCTAC
AAGCACATTAGCCTGGGGTGTAAACTTTCCAGCTCATTTAGTAATTATTAAGGGAACAGAATACTATGATGGAAAAACAAGACGTTATGT
GGATTTTCCCATTACAGATGTCCTCCAGATGATGGGGCGTGCTGGGAGGCCGCAGTTCGATGACCAAGGCAAAGCTGTAATTCTAGTTCA
TGACATAAAGAAAGACTTTTATAAAAAATTTCTTTATGAACCTTTCCCAGTAGAATCAAGTTTATTAGGAGTGCTCTCTGACCACTTAAA
TGCAGAGATTGCTGGTGGTACAATTACATCTAAGCAAGATGCATTGGATTATATCACCTGGACTTACTTTTTCCGACGTCTTATCATGAA
TCCCAGCTATTACAATTTGGGTGATGTGAGCCATGATTCTGTGAACAAGTTTCTGTCCCATCTGATTGAGAAGTCCCTGATTGAATTGGA
ACTTTCCTACTGTATTGAAATTGGAGAGGATAATCGCAGCATTGAACCTCTAACTTATGGCCGAATTGCCTCCTATTACTATTTGAAGCA
TCAAACAGTTAAAATGTTCAAGGACCGCTTGAAGCCTGAATGCAGTACTGAAGAACTGCTTTCAATTCTAAGTGATGCAGAAGAATATAC
AGATTTGCCAGTGAGACACAATGAAGATCATATGAATAGTGAACTGGCAAAATGTCTTCCCATTGAATCAAATCCTCATTCATTTGACAG
CCCTCACACCAAAGCACATCTCCTGCTACAGGCACATCTCAGCCGAGCCATGCTACCCTGCCCAGATTATGACACTGATACCAAAACAGT
CTTGGACCAAGCTCTCAGAGTATGTCAGGCAATGCTGGACGTGGCTGCAAACCAGGGCTGGCTGGTGACTGTCCTGAATATCACCAACCT
GATTCAGATGGTGATCCAGGGTCGGTGGTTAAAGGACTCTTCTCTTCTTACACTACCAAACATAGAAAACCATCATCTTCACCTTTTCAA
GAAATGGAAGCCGATTATGAAGGGCCCACATGCTAGGGGTCGGACCTCCATCGAGTCCCTTCCTGAACTGATCCATGCCTGTGGAGGGAA
AGACCATGTATTTAGCTCCATGGTAGAAAGTGAGCTACATGCTGCAAAAACGAAACAGGCATGGAATTTCTTATCTCACTTGCCAGTGAT
AAATGTTGGCATAAGTGTTAAAGGCTCGTGGGATGACTTAGTTGAAGGACATAATGAACTCTCTGTCTCAACTCTGACTGCAGACAAACG
AGATGACAACAAATGGATCAAATTGCATGCTGACCAAGAGTATGTGCTTCAAGTGAGCTTGCAGAGAGTCCACTTTGGGTTCCACAAGGG
AAAGCCAGAGAGCTGTGCAGTTACTCCTCGATTTCCCAAATCAAAAGACGAAGGATGGTTTTTGATATTAGGAGAAGTGGATAAGAGAGA
ACTTATTGCTTTGAAAAGAGTAGGATATATTCGAAATCATCATGTTGCTTCCCTTTCTTTTTATACCCCTGAAATACCTGGAAGGTATAT
CTACACATTATATTTCATGAGTGACTGCTACCTTGGCCTGGACCAGCAGTATGACATCTATCTCAACGTTACACAAGCGAGTCTTTCTGC
ACAGGTCAACACCAAGGTCTCTGATTCCCTGACTGACCTGGCATTAAAGTAACTTGACCTGAACAATCCATTTGAAAGGAGTGGCTAAGA
ATTCTCTCTGTTCAGTCATCTAGACAAATCGAATTACTTGATGTTTGCCTTGAAAGAATCAACTTCTAACCTCAACCATCCAGGAAATTG
ACAGTGGCTGCAGTATTGACTCCAGTGACATAAAGTTAACCACAGTGGCCTTTTAACAAATGTTGCCTTTTATAATGTTATCTTTATGAG
TTTCTTGATATGTAAGATGAAAAAGCATTTAGAATAATCTTTTAATTTGTGTATATTTGGGATGATATTTAGGAGCTATCAATCAAATTT
TACATCTCACAATGTACTGTTTACATGGATATTGGCTGCTTTTTTTAAGGAAAACCACATTGAGATGTGACAAGTGTTAGGACTTGTCAC
AGATTTCTAACTCTGCCGCATAAACTATAAATCTGTAAGGTGGTACACAGCGTGTCTTGTTAGCAAAATTTATACTTTGATATGATCACA
TGTAGAAGTAGCTTCAAGAATTTCTTGTAGTCATAAATGTTTAATAATATATGATGTAAAATTATATTATGGAGCCTAATGATGATAACA
AAGAAAACAATATACTGATCTTAGAAAATGTAGACATGGTTAACTGGGAAATAAAATATAGAGTGGCACTTCAAGACAAGCTGACTCAAT
GTTTTCTTCTGCTTCCTTTAAATAATATCCCCTTACTCATCTGTTCTTCTTTTCTTTCCCTTCTACTTCAAGGCTTTATTTCTATTATCT
TTCTGACATATTTATTTACAGAAGTAGAGAAGTATAATCTAATTCATGTTGTAGCACTTACAGATCATATAGTACAATTATTTGTCTTTA
TGCTCTCCAGGAAAAATCTGAGACAGAAAATTTTTCACCCCTATGGATAGGTTTTCACCTGTAATAAAGAAAATTTCTCTATGTCCAAAC
AAATTCCTTCTTGAAAAATACTTTTTCAAACTAAAAACTTGTTAAAATTCAATGTTCATATAATATGCATTCTAGTGGAATGAAATTCTA
CCTTTGTGAAATAATTTCAGTTTTCTTAGCCCTAAAATGAATTATTTTAAAACATTTTCCAATGTCATTGTTACAAATACTAGAATTTAA

>60642_60642_2_NT5E-ASCC3_NT5E_chr6_86160196_ENST00000369646_ASCC3_chr6_101054964_ENST00000369162_length(amino acids)=720AA_BP=113
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGT
IWFTVYKGAEVAHFMNALRYDAMMENIIATVRDSNLKLTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVII
KGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVILVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEIAGGTITSKQDALD
YITWTYFFRRLIMNPSYYNLGDVSHDSVNKFLSHLIEKSLIELELSYCIEIGEDNRSIEPLTYGRIASYYYLKHQTVKMFKDRLKPECST
EELLSILSDAEEYTDLPVRHNEDHMNSELAKCLPIESNPHSFDSPHTKAHLLLQAHLSRAMLPCPDYDTDTKTVLDQALRVCQAMLDVAA
NQGWLVTVLNITNLIQMVIQGRWLKDSSLLTLPNIENHHLHLFKKWKPIMKGPHARGRTSIESLPELIHACGGKDHVFSSMVESELHAAK
TKQAWNFLSHLPVINVGISVKGSWDDLVEGHNELSVSTLTADKRDDNKWIKLHADQEYVLQVSLQRVHFGFHKGKPESCAVTPRFPKSKD
EGWFLILGEVDKRELIALKRVGYIRNHHVASLSFYTPEIPGRYIYTLYFMSDCYLGLDQQYDIYLNVTQASLSAQVNTKVSDSLTDLALK

--------------------------------------------------------------
>60642_60642_3_NT5E-ASCC3_NT5E_chr6_86160196_ENST00000369651_ASCC3_chr6_101054964_ENST00000369162_length(transcript)=3386nt_BP=370nt
CGCTTTCGCACCCAGTTCACGCGCCACAGCTATGTGTCCCCGAGCCGCGCGGGCGCCCGCGACGCTACTCCTCGCCCTGGGCGCGGTGCT
GTGGCCTGCGGCTGGCGCCTGGGAGCTTACGATTTTGCACACCAACGACGTGCACAGCCGGCTGGAGCAGACCAGCGAGGACTCCAGCAA
GTGCGTCAACGCCAGCCGCTGCATGGGTGGCGTGGCTCGGCTCTTCACCAAGGTTCAGCAGATCCGCCGCGCCGAACCCAACGTGCTGCT
GCTGGACGCCGGCGACCAGTACCAGGGCACTATCTGGTTCACCGTGTACAAGGGCGCCGAGGTGGCGCACTTCATGAACGCCCTGCGCTA
CGATGCCATGATGGAGAACATCATTGCAACAGTAAGAGATTCCAACCTCAAGCTGACCCTTGCTTTCGGGATAGGAATGCATCATGCTGG
ACTACATGAGAGGGACCGAAAAACAGTAGAGGAACTATTTGTAAACTGTAAAGTTCAGGTTCTTATTGCTACAAGCACATTAGCCTGGGG
TGTAAACTTTCCAGCTCATTTAGTAATTATTAAGGGAACAGAATACTATGATGGAAAAACAAGACGTTATGTGGATTTTCCCATTACAGA
TGTCCTCCAGATGATGGGGCGTGCTGGGAGGCCGCAGTTCGATGACCAAGGCAAAGCTGTAATTCTAGTTCATGACATAAAGAAAGACTT
TTATAAAAAATTTCTTTATGAACCTTTCCCAGTAGAATCAAGTTTATTAGGAGTGCTCTCTGACCACTTAAATGCAGAGATTGCTGGTGG
TACAATTACATCTAAGCAAGATGCATTGGATTATATCACCTGGACTTACTTTTTCCGACGTCTTATCATGAATCCCAGCTATTACAATTT
GGGTGATGTGAGCCATGATTCTGTGAACAAGTTTCTGTCCCATCTGATTGAGAAGTCCCTGATTGAATTGGAACTTTCCTACTGTATTGA
AATTGGAGAGGATAATCGCAGCATTGAACCTCTAACTTATGGCCGAATTGCCTCCTATTACTATTTGAAGCATCAAACAGTTAAAATGTT
CAAGGACCGCTTGAAGCCTGAATGCAGTACTGAAGAACTGCTTTCAATTCTAAGTGATGCAGAAGAATATACAGATTTGCCAGTGAGACA
CAATGAAGATCATATGAATAGTGAACTGGCAAAATGTCTTCCCATTGAATCAAATCCTCATTCATTTGACAGCCCTCACACCAAAGCACA
TCTCCTGCTACAGGCACATCTCAGCCGAGCCATGCTACCCTGCCCAGATTATGACACTGATACCAAAACAGTCTTGGACCAAGCTCTCAG
AGTATGTCAGGCAATGCTGGACGTGGCTGCAAACCAGGGCTGGCTGGTGACTGTCCTGAATATCACCAACCTGATTCAGATGGTGATCCA
GGGTCGGTGGTTAAAGGACTCTTCTCTTCTTACACTACCAAACATAGAAAACCATCATCTTCACCTTTTCAAGAAATGGAAGCCGATTAT
GAAGGGCCCACATGCTAGGGGTCGGACCTCCATCGAGTCCCTTCCTGAACTGATCCATGCCTGTGGAGGGAAAGACCATGTATTTAGCTC
CATGGTAGAAAGTGAGCTACATGCTGCAAAAACGAAACAGGCATGGAATTTCTTATCTCACTTGCCAGTGATAAATGTTGGCATAAGTGT
TAAAGGCTCGTGGGATGACTTAGTTGAAGGACATAATGAACTCTCTGTCTCAACTCTGACTGCAGACAAACGAGATGACAACAAATGGAT
CAAATTGCATGCTGACCAAGAGTATGTGCTTCAAGTGAGCTTGCAGAGAGTCCACTTTGGGTTCCACAAGGGAAAGCCAGAGAGCTGTGC
AGTTACTCCTCGATTTCCCAAATCAAAAGACGAAGGATGGTTTTTGATATTAGGAGAAGTGGATAAGAGAGAACTTATTGCTTTGAAAAG
AGTAGGATATATTCGAAATCATCATGTTGCTTCCCTTTCTTTTTATACCCCTGAAATACCTGGAAGGTATATCTACACATTATATTTCAT
GAGTGACTGCTACCTTGGCCTGGACCAGCAGTATGACATCTATCTCAACGTTACACAAGCGAGTCTTTCTGCACAGGTCAACACCAAGGT
CTCTGATTCCCTGACTGACCTGGCATTAAAGTAACTTGACCTGAACAATCCATTTGAAAGGAGTGGCTAAGAATTCTCTCTGTTCAGTCA
TCTAGACAAATCGAATTACTTGATGTTTGCCTTGAAAGAATCAACTTCTAACCTCAACCATCCAGGAAATTGACAGTGGCTGCAGTATTG
ACTCCAGTGACATAAAGTTAACCACAGTGGCCTTTTAACAAATGTTGCCTTTTATAATGTTATCTTTATGAGTTTCTTGATATGTAAGAT
GAAAAAGCATTTAGAATAATCTTTTAATTTGTGTATATTTGGGATGATATTTAGGAGCTATCAATCAAATTTTACATCTCACAATGTACT
GTTTACATGGATATTGGCTGCTTTTTTTAAGGAAAACCACATTGAGATGTGACAAGTGTTAGGACTTGTCACAGATTTCTAACTCTGCCG
CATAAACTATAAATCTGTAAGGTGGTACACAGCGTGTCTTGTTAGCAAAATTTATACTTTGATATGATCACATGTAGAAGTAGCTTCAAG
AATTTCTTGTAGTCATAAATGTTTAATAATATATGATGTAAAATTATATTATGGAGCCTAATGATGATAACAAAGAAAACAATATACTGA
TCTTAGAAAATGTAGACATGGTTAACTGGGAAATAAAATATAGAGTGGCACTTCAAGACAAGCTGACTCAATGTTTTCTTCTGCTTCCTT
TAAATAATATCCCCTTACTCATCTGTTCTTCTTTTCTTTCCCTTCTACTTCAAGGCTTTATTTCTATTATCTTTCTGACATATTTATTTA
CAGAAGTAGAGAAGTATAATCTAATTCATGTTGTAGCACTTACAGATCATATAGTACAATTATTTGTCTTTATGCTCTCCAGGAAAAATC
TGAGACAGAAAATTTTTCACCCCTATGGATAGGTTTTCACCTGTAATAAAGAAAATTTCTCTATGTCCAAACAAATTCCTTCTTGAAAAA
TACTTTTTCAAACTAAAAACTTGTTAAAATTCAATGTTCATATAATATGCATTCTAGTGGAATGAAATTCTACCTTTGTGAAATAATTTC
AGTTTTCTTAGCCCTAAAATGAATTATTTTAAAACATTTTCCAATGTCATTGTTACAAATACTAGAATTTAAGTGTTTCTGAAATTGGAA

>60642_60642_3_NT5E-ASCC3_NT5E_chr6_86160196_ENST00000369651_ASCC3_chr6_101054964_ENST00000369162_length(amino acids)=720AA_BP=113
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGT
IWFTVYKGAEVAHFMNALRYDAMMENIIATVRDSNLKLTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVII
KGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVILVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEIAGGTITSKQDALD
YITWTYFFRRLIMNPSYYNLGDVSHDSVNKFLSHLIEKSLIELELSYCIEIGEDNRSIEPLTYGRIASYYYLKHQTVKMFKDRLKPECST
EELLSILSDAEEYTDLPVRHNEDHMNSELAKCLPIESNPHSFDSPHTKAHLLLQAHLSRAMLPCPDYDTDTKTVLDQALRVCQAMLDVAA
NQGWLVTVLNITNLIQMVIQGRWLKDSSLLTLPNIENHHLHLFKKWKPIMKGPHARGRTSIESLPELIHACGGKDHVFSSMVESELHAAK
TKQAWNFLSHLPVINVGISVKGSWDDLVEGHNELSVSTLTADKRDDNKWIKLHADQEYVLQVSLQRVHFGFHKGKPESCAVTPRFPKSKD
EGWFLILGEVDKRELIALKRVGYIRNHHVASLSFYTPEIPGRYIYTLYFMSDCYLGLDQQYDIYLNVTQASLSAQVNTKVSDSLTDLALK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NT5E-ASCC3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for NT5E-ASCC3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for NT5E-ASCC3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source