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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NTN1-STX8 (FusionGDB2 ID:60673)

Fusion Gene Summary for NTN1-STX8

check button Fusion gene summary
Fusion gene informationFusion gene name: NTN1-STX8
Fusion gene ID: 60673
HgeneTgene
Gene symbol

NTN1

STX8

Gene ID

9423

9482

Gene namenetrin 1syntaxin 8
SynonymsMRMV4|NTN1LCARB
Cytomap

17p13.1

17p13.1

Type of geneprotein-codingprotein-coding
Descriptionnetrin-1epididymis tissue protein Li 131Pnetrin 1, mouse, homolog ofsyntaxin-8CIP-1-associated regulator of cyclin B
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000173229, ENST00000538852, 
ENST00000546090, 		ENST00000573373, 
ENST00000306357, ENST00000574431, 
Fusion gene scores* DoF score7 X 4 X 6=16824 X 16 X 8=3072
# samples 1129
** MAII scorelog2(11/168*10)=-0.610957709254101
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(29/3072*10)=-3.40505341070622
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NTN1 [Title/Abstract] AND STX8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNTN1(9086286)-STX8(9153962), # samples:2
NTN1(9124559)-STX8(9153962), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSTX8

GO:0045022

early endosome to late endosome transport

10564279

TgeneSTX8

GO:1903076

regulation of protein localization to plasma membrane

18570918


check buttonFusion gene breakpoints across NTN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across STX8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-21-5784-01ANTN1chr17

9086286

-STX8chr17

9153962

-
ChimerDB4OVTCGA-04-1651NTN1chr17

9086286

+STX8chr17

9153962

-
ChimerDB4STADTCGA-BR-8058-01ANTN1chr17

8926708

+STX8chr17

9153962

-
ChimerDB4STADTCGA-BR-A4J7NTN1chr17

8926708

+STX8chr17

9281970

-
ChimerDB4STADTCGA-D7-8570-01ANTN1chr17

9124559

+STX8chr17

9153962

-
ChimerDB4STADTCGA-D7-8570NTN1chr17

9124559

+STX8chr17

9153962

-


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Fusion Gene ORF analysis for NTN1-STX8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000173229ENST00000573373NTN1chr17

9086286

+STX8chr17

9153962

-
5CDS-intronENST00000173229ENST00000573373NTN1chr17

8926708

+STX8chr17

9153962

-
5CDS-intronENST00000173229ENST00000573373NTN1chr17

8926708

+STX8chr17

9281970

-
5CDS-intronENST00000173229ENST00000573373NTN1chr17

9124559

+STX8chr17

9153962

-
5CDS-intronENST00000538852ENST00000573373NTN1chr17

9086286

+STX8chr17

9153962

-
5CDS-intronENST00000538852ENST00000573373NTN1chr17

8926708

+STX8chr17

9153962

-
5CDS-intronENST00000538852ENST00000573373NTN1chr17

8926708

+STX8chr17

9281970

-
5CDS-intronENST00000538852ENST00000573373NTN1chr17

9124559

+STX8chr17

9153962

-
5CDS-intronENST00000546090ENST00000573373NTN1chr17

9086286

+STX8chr17

9153962

-
5CDS-intronENST00000546090ENST00000573373NTN1chr17

8926708

+STX8chr17

9153962

-
5CDS-intronENST00000546090ENST00000573373NTN1chr17

8926708

+STX8chr17

9281970

-
5CDS-intronENST00000546090ENST00000573373NTN1chr17

9124559

+STX8chr17

9153962

-
Frame-shiftENST00000173229ENST00000306357NTN1chr17

9086286

+STX8chr17

9153962

-
Frame-shiftENST00000173229ENST00000306357NTN1chr17

8926708

+STX8chr17

9153962

-
Frame-shiftENST00000173229ENST00000306357NTN1chr17

9124559

+STX8chr17

9153962

-
Frame-shiftENST00000173229ENST00000574431NTN1chr17

9086286

+STX8chr17

9153962

-
Frame-shiftENST00000173229ENST00000574431NTN1chr17

8926708

+STX8chr17

9153962

-
Frame-shiftENST00000173229ENST00000574431NTN1chr17

9124559

+STX8chr17

9153962

-
Frame-shiftENST00000538852ENST00000306357NTN1chr17

9086286

+STX8chr17

9153962

-
Frame-shiftENST00000538852ENST00000306357NTN1chr17

8926708

+STX8chr17

9153962

-
Frame-shiftENST00000538852ENST00000306357NTN1chr17

9124559

+STX8chr17

9153962

-
Frame-shiftENST00000538852ENST00000574431NTN1chr17

9086286

+STX8chr17

9153962

-
Frame-shiftENST00000538852ENST00000574431NTN1chr17

8926708

+STX8chr17

9153962

-
Frame-shiftENST00000538852ENST00000574431NTN1chr17

9124559

+STX8chr17

9153962

-
Frame-shiftENST00000546090ENST00000306357NTN1chr17

9086286

+STX8chr17

9153962

-
Frame-shiftENST00000546090ENST00000306357NTN1chr17

8926708

+STX8chr17

9153962

-
Frame-shiftENST00000546090ENST00000306357NTN1chr17

9124559

+STX8chr17

9153962

-
Frame-shiftENST00000546090ENST00000574431NTN1chr17

9086286

+STX8chr17

9153962

-
Frame-shiftENST00000546090ENST00000574431NTN1chr17

8926708

+STX8chr17

9153962

-
Frame-shiftENST00000546090ENST00000574431NTN1chr17

9124559

+STX8chr17

9153962

-
In-frameENST00000173229ENST00000306357NTN1chr17

8926708

+STX8chr17

9281970

-
In-frameENST00000173229ENST00000574431NTN1chr17

8926708

+STX8chr17

9281970

-
In-frameENST00000538852ENST00000306357NTN1chr17

8926708

+STX8chr17

9281970

-
In-frameENST00000538852ENST00000574431NTN1chr17

8926708

+STX8chr17

9281970

-
In-frameENST00000546090ENST00000306357NTN1chr17

8926708

+STX8chr17

9281970

-
In-frameENST00000546090ENST00000574431NTN1chr17

8926708

+STX8chr17

9281970

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000173229NTN1chr178926708+ENST00000306357STX8chr179281970-140211251071294395
ENST00000173229NTN1chr178926708+ENST00000574431STX8chr179281970-138611251071294395
ENST00000538852NTN1chr178926708+ENST00000306357STX8chr179281970-140111241061293395
ENST00000538852NTN1chr178926708+ENST00000574431STX8chr179281970-138511241061293395
ENST00000546090NTN1chr178926708+ENST00000306357STX8chr179281970-13661089711258395
ENST00000546090NTN1chr178926708+ENST00000574431STX8chr179281970-13501089711258395

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000173229ENST00000306357NTN1chr178926708+STX8chr179281970-0.0169165710.9830835
ENST00000173229ENST00000574431NTN1chr178926708+STX8chr179281970-0.0159503020.9840497
ENST00000538852ENST00000306357NTN1chr178926708+STX8chr179281970-0.0195690110.980431
ENST00000538852ENST00000574431NTN1chr178926708+STX8chr179281970-0.0181739540.98182607
ENST00000546090ENST00000306357NTN1chr178926708+STX8chr179281970-0.0177803650.9822196
ENST00000546090ENST00000574431NTN1chr178926708+STX8chr179281970-0.0166603510.98333967

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Fusion Genomic Features for NTN1-STX8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NTN1-STX8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:9086286/chr17:9153962)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNTN1chr17:8926708chr17:9281970ENST00000173229+27285_340339605.0DomainLaminin EGF-like 1
HgeneNTN1chr17:8926708chr17:9281970ENST00000173229+2747_284339605.0DomainLaminin N-terminal
HgeneNTN1chr17:8926708chr17:9281970ENST00000538852+27285_340339605.0DomainLaminin EGF-like 1
HgeneNTN1chr17:8926708chr17:9281970ENST00000538852+2747_284339605.0DomainLaminin N-terminal
HgeneNTN1chr17:8926708chr17:9281970ENST00000546090+16285_340339605.0DomainLaminin EGF-like 1
HgeneNTN1chr17:8926708chr17:9281970ENST00000546090+1647_284339605.0DomainLaminin N-terminal
TgeneSTX8chr17:8926708chr17:9281970ENST0000030635758233_236180237.0Topological domainVesicular
TgeneSTX8chr17:8926708chr17:9281970ENST0000030635758216_232180237.0TransmembraneHelical%3B Anchor for type IV membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNTN1chr17:8926708chr17:9281970ENST00000173229+27341_403339605.0DomainLaminin EGF-like 2
HgeneNTN1chr17:8926708chr17:9281970ENST00000173229+27404_453339605.0DomainLaminin EGF-like 3
HgeneNTN1chr17:8926708chr17:9281970ENST00000173229+27472_601339605.0DomainNTR
HgeneNTN1chr17:8926708chr17:9281970ENST00000538852+27341_403339605.0DomainLaminin EGF-like 2
HgeneNTN1chr17:8926708chr17:9281970ENST00000538852+27404_453339605.0DomainLaminin EGF-like 3
HgeneNTN1chr17:8926708chr17:9281970ENST00000538852+27472_601339605.0DomainNTR
HgeneNTN1chr17:8926708chr17:9281970ENST00000546090+16341_403339605.0DomainLaminin EGF-like 2
HgeneNTN1chr17:8926708chr17:9281970ENST00000546090+16404_453339605.0DomainLaminin EGF-like 3
HgeneNTN1chr17:8926708chr17:9281970ENST00000546090+16472_601339605.0DomainNTR
HgeneNTN1chr17:8926708chr17:9281970ENST00000173229+27530_532339605.0MotifCell attachment site
HgeneNTN1chr17:8926708chr17:9281970ENST00000538852+27530_532339605.0MotifCell attachment site
HgeneNTN1chr17:8926708chr17:9281970ENST00000546090+16530_532339605.0MotifCell attachment site
TgeneSTX8chr17:8926708chr17:9281970ENST000003063575842_65180237.0Coiled coilOntology_term=ECO:0000255
TgeneSTX8chr17:8926708chr17:9281970ENST0000030635758145_207180237.0Domaint-SNARE coiled-coil homology
TgeneSTX8chr17:8926708chr17:9281970ENST00000306357581_215180237.0Topological domainCytoplasmic


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Fusion Gene Sequence for NTN1-STX8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>60673_60673_1_NTN1-STX8_NTN1_chr17_8926708_ENST00000173229_STX8_chr17_9281970_ENST00000306357_length(transcript)=1402nt_BP=1125nt
CTTCGGGGGCGAGCGCGCGTGTGTGTGAGTGCGCGCCGGCCAGCGCGCCTTCTGCGGCAGGCGGACAGATCCTCGGCGCGGCAGGGCCGG
GGCAAGCTGGACGCAGCATGATGCGCGCAGTGTGGGAGGCGCTGGCGGCGCTGGCGGCGGTGGCGTGCCTGGTGGGCGCGGTGCGCGGCG
GGCCCGGGCTCAGCATGTTCGCGGGCCAGGCGGCGCAGCCCGATCCCTGCTCGGACGAGAACGGCCACCCGCGCCGCTGCATCCCGGACT
TTGTCAATGCGGCCTTCGGCAAGGACGTGCGCGTGTCCAGCACCTGCGGCCGGCCCCCGGCGCGCTACTGCGTGGTGAGCGAGCGCGGCG
AGGAGCGGCTGCGCTCGTGCCACCTCTGCAACGCGTCCGACCCCAAGAAGGCGCACCCGCCCGCCTTCCTCACCGACCTCAACAACCCGC
ACAACCTGACGTGCTGGCAGTCCGAGAACTACCTGCAGTTCCCGCACAACGTCACGCTCACACTGTCCCTCGGCAAGAAGTTCGAAGTGA
CCTACGTGAGCCTGCAGTTCTGCTCGCCGCGGCCCGAGTCCATGGCCATCTACAAGTCCATGGACTACGGGCGCACGTGGGTGCCCTTCC
AGTTCTACTCCACGCAGTGCCGCAAGATGTACAACCGGCCGCACCGCGCGCCCATCACCAAGCAGAACGAGCAGGAGGCCGTGTGCACCG
ACTCGCACACCGACATGCGCCCGCTCTCGGGCGGCCTCATCGCCTTCAGCACGCTGGACGGGCGGCCCTCGGCGCACGACTTCGACAACT
CGCCCGTGCTGCAGGACTGGGTCACGGCCACAGACATCCGCGTGGCCTTCAGCCGCCTGCACACGTTCGGCGACGAGAACGAGGACGACT
CGGAGCTGGCGCGCGACTCGTACTTCTACGCGGTGTCCGACCTGCAGGTGGGCGGCCGGTGCAAGTGCAACGGCCACGCGGCCCGCTGCG
TGCGCGACCGCGACGACAGCCTGGTGTGCGACTGCAGGCACAACACGGCCGGCCCGGAGTGCGACCGCTGCAAGCCCTTCCACTACGACC
GGCCCTGGCAGCGCGCCACAGCCCGCGAAGCCAACGAGTGCGTGGAGATAATTGACGACCTTGCCAACCTAGTGGAGAACACAGATGAAA
AACTTCGCAATGAAACCAGGCGGGTAAACATGGTGGACAGAAAGTCAGCCTCTTGTGGGATGATCATGGTGATTTTACTGCTGCTTGTGG
CTATCGTGGTTGTTGCAGTCTGGCCGACCAACTGATGGCAGTAAAGAGACCACCAGCAGTGACACCTGCCAATGACAGATGCAAGCCCAA

>60673_60673_1_NTN1-STX8_NTN1_chr17_8926708_ENST00000173229_STX8_chr17_9281970_ENST00000306357_length(amino acids)=395AA_BP=339
MMRAVWEALAALAAVACLVGAVRGGPGLSMFAGQAAQPDPCSDENGHPRRCIPDFVNAAFGKDVRVSSTCGRPPARYCVVSERGEERLRS
CHLCNASDPKKAHPPAFLTDLNNPHNLTCWQSENYLQFPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGRTWVPFQFYSTQ
CRKMYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGLIAFSTLDGRPSAHDFDNSPVLQDWVTATDIRVAFSRLHTFGDENEDDSELARD
SYFYAVSDLQVGGRCKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVEIIDDLANLVENTDEKLRNET

--------------------------------------------------------------
>60673_60673_2_NTN1-STX8_NTN1_chr17_8926708_ENST00000173229_STX8_chr17_9281970_ENST00000574431_length(transcript)=1386nt_BP=1125nt
CTTCGGGGGCGAGCGCGCGTGTGTGTGAGTGCGCGCCGGCCAGCGCGCCTTCTGCGGCAGGCGGACAGATCCTCGGCGCGGCAGGGCCGG
GGCAAGCTGGACGCAGCATGATGCGCGCAGTGTGGGAGGCGCTGGCGGCGCTGGCGGCGGTGGCGTGCCTGGTGGGCGCGGTGCGCGGCG
GGCCCGGGCTCAGCATGTTCGCGGGCCAGGCGGCGCAGCCCGATCCCTGCTCGGACGAGAACGGCCACCCGCGCCGCTGCATCCCGGACT
TTGTCAATGCGGCCTTCGGCAAGGACGTGCGCGTGTCCAGCACCTGCGGCCGGCCCCCGGCGCGCTACTGCGTGGTGAGCGAGCGCGGCG
AGGAGCGGCTGCGCTCGTGCCACCTCTGCAACGCGTCCGACCCCAAGAAGGCGCACCCGCCCGCCTTCCTCACCGACCTCAACAACCCGC
ACAACCTGACGTGCTGGCAGTCCGAGAACTACCTGCAGTTCCCGCACAACGTCACGCTCACACTGTCCCTCGGCAAGAAGTTCGAAGTGA
CCTACGTGAGCCTGCAGTTCTGCTCGCCGCGGCCCGAGTCCATGGCCATCTACAAGTCCATGGACTACGGGCGCACGTGGGTGCCCTTCC
AGTTCTACTCCACGCAGTGCCGCAAGATGTACAACCGGCCGCACCGCGCGCCCATCACCAAGCAGAACGAGCAGGAGGCCGTGTGCACCG
ACTCGCACACCGACATGCGCCCGCTCTCGGGCGGCCTCATCGCCTTCAGCACGCTGGACGGGCGGCCCTCGGCGCACGACTTCGACAACT
CGCCCGTGCTGCAGGACTGGGTCACGGCCACAGACATCCGCGTGGCCTTCAGCCGCCTGCACACGTTCGGCGACGAGAACGAGGACGACT
CGGAGCTGGCGCGCGACTCGTACTTCTACGCGGTGTCCGACCTGCAGGTGGGCGGCCGGTGCAAGTGCAACGGCCACGCGGCCCGCTGCG
TGCGCGACCGCGACGACAGCCTGGTGTGCGACTGCAGGCACAACACGGCCGGCCCGGAGTGCGACCGCTGCAAGCCCTTCCACTACGACC
GGCCCTGGCAGCGCGCCACAGCCCGCGAAGCCAACGAGTGCGTGGAGATAATTGACGACCTTGCCAACCTAGTGGAGAACACAGATGAAA
AACTTCGCAATGAAACCAGGCGGGTAAACATGGTGGACAGAAAGTCAGCCTCTTGTGGGATGATCATGGTGATTTTACTGCTGCTTGTGG
CTATCGTGGTTGTTGCAGTCTGGCCGACCAACTGATGGCAGTAAAGAGACCACCAGCAGTGACACCTGCCAATGACAGATGCAAGCCCAA

>60673_60673_2_NTN1-STX8_NTN1_chr17_8926708_ENST00000173229_STX8_chr17_9281970_ENST00000574431_length(amino acids)=395AA_BP=339
MMRAVWEALAALAAVACLVGAVRGGPGLSMFAGQAAQPDPCSDENGHPRRCIPDFVNAAFGKDVRVSSTCGRPPARYCVVSERGEERLRS
CHLCNASDPKKAHPPAFLTDLNNPHNLTCWQSENYLQFPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGRTWVPFQFYSTQ
CRKMYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGLIAFSTLDGRPSAHDFDNSPVLQDWVTATDIRVAFSRLHTFGDENEDDSELARD
SYFYAVSDLQVGGRCKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVEIIDDLANLVENTDEKLRNET

--------------------------------------------------------------
>60673_60673_3_NTN1-STX8_NTN1_chr17_8926708_ENST00000538852_STX8_chr17_9281970_ENST00000306357_length(transcript)=1401nt_BP=1124nt
CTCCGCTCGCCACCCCGCCGAGAGCTGGAGGGCGCGGGGCCAGGCGCCTTCTGCGGCAGGCGGACAGATCCTCGGCGCGGCAGGGCCGGG
GCAAGCTGGACGCAGCATGATGCGCGCAGTGTGGGAGGCGCTGGCGGCGCTGGCGGCGGTGGCGTGCCTGGTGGGCGCGGTGCGCGGCGG
GCCCGGGCTCAGCATGTTCGCGGGCCAGGCGGCGCAGCCCGATCCCTGCTCGGACGAGAACGGCCACCCGCGCCGCTGCATCCCGGACTT
TGTCAATGCGGCCTTCGGCAAGGACGTGCGCGTGTCCAGCACCTGCGGCCGGCCCCCGGCGCGCTACTGCGTGGTGAGCGAGCGCGGCGA
GGAGCGGCTGCGCTCGTGCCACCTCTGCAACGCGTCCGACCCCAAGAAGGCGCACCCGCCCGCCTTCCTCACCGACCTCAACAACCCGCA
CAACCTGACGTGCTGGCAGTCCGAGAACTACCTGCAGTTCCCGCACAACGTCACGCTCACACTGTCCCTCGGCAAGAAGTTCGAAGTGAC
CTACGTGAGCCTGCAGTTCTGCTCGCCGCGGCCCGAGTCCATGGCCATCTACAAGTCCATGGACTACGGGCGCACGTGGGTGCCCTTCCA
GTTCTACTCCACGCAGTGCCGCAAGATGTACAACCGGCCGCACCGCGCGCCCATCACCAAGCAGAACGAGCAGGAGGCCGTGTGCACCGA
CTCGCACACCGACATGCGCCCGCTCTCGGGCGGCCTCATCGCCTTCAGCACGCTGGACGGGCGGCCCTCGGCGCACGACTTCGACAACTC
GCCCGTGCTGCAGGACTGGGTCACGGCCACAGACATCCGCGTGGCCTTCAGCCGCCTGCACACGTTCGGCGACGAGAACGAGGACGACTC
GGAGCTGGCGCGCGACTCGTACTTCTACGCGGTGTCCGACCTGCAGGTGGGCGGCCGGTGCAAGTGCAACGGCCACGCGGCCCGCTGCGT
GCGCGACCGCGACGACAGCCTGGTGTGCGACTGCAGGCACAACACGGCCGGCCCGGAGTGCGACCGCTGCAAGCCCTTCCACTACGACCG
GCCCTGGCAGCGCGCCACAGCCCGCGAAGCCAACGAGTGCGTGGAGATAATTGACGACCTTGCCAACCTAGTGGAGAACACAGATGAAAA
ACTTCGCAATGAAACCAGGCGGGTAAACATGGTGGACAGAAAGTCAGCCTCTTGTGGGATGATCATGGTGATTTTACTGCTGCTTGTGGC
TATCGTGGTTGTTGCAGTCTGGCCGACCAACTGATGGCAGTAAAGAGACCACCAGCAGTGACACCTGCCAATGACAGATGCAAGCCCAAC

>60673_60673_3_NTN1-STX8_NTN1_chr17_8926708_ENST00000538852_STX8_chr17_9281970_ENST00000306357_length(amino acids)=395AA_BP=339
MMRAVWEALAALAAVACLVGAVRGGPGLSMFAGQAAQPDPCSDENGHPRRCIPDFVNAAFGKDVRVSSTCGRPPARYCVVSERGEERLRS
CHLCNASDPKKAHPPAFLTDLNNPHNLTCWQSENYLQFPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGRTWVPFQFYSTQ
CRKMYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGLIAFSTLDGRPSAHDFDNSPVLQDWVTATDIRVAFSRLHTFGDENEDDSELARD
SYFYAVSDLQVGGRCKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVEIIDDLANLVENTDEKLRNET

--------------------------------------------------------------
>60673_60673_4_NTN1-STX8_NTN1_chr17_8926708_ENST00000538852_STX8_chr17_9281970_ENST00000574431_length(transcript)=1385nt_BP=1124nt
CTCCGCTCGCCACCCCGCCGAGAGCTGGAGGGCGCGGGGCCAGGCGCCTTCTGCGGCAGGCGGACAGATCCTCGGCGCGGCAGGGCCGGG
GCAAGCTGGACGCAGCATGATGCGCGCAGTGTGGGAGGCGCTGGCGGCGCTGGCGGCGGTGGCGTGCCTGGTGGGCGCGGTGCGCGGCGG
GCCCGGGCTCAGCATGTTCGCGGGCCAGGCGGCGCAGCCCGATCCCTGCTCGGACGAGAACGGCCACCCGCGCCGCTGCATCCCGGACTT
TGTCAATGCGGCCTTCGGCAAGGACGTGCGCGTGTCCAGCACCTGCGGCCGGCCCCCGGCGCGCTACTGCGTGGTGAGCGAGCGCGGCGA
GGAGCGGCTGCGCTCGTGCCACCTCTGCAACGCGTCCGACCCCAAGAAGGCGCACCCGCCCGCCTTCCTCACCGACCTCAACAACCCGCA
CAACCTGACGTGCTGGCAGTCCGAGAACTACCTGCAGTTCCCGCACAACGTCACGCTCACACTGTCCCTCGGCAAGAAGTTCGAAGTGAC
CTACGTGAGCCTGCAGTTCTGCTCGCCGCGGCCCGAGTCCATGGCCATCTACAAGTCCATGGACTACGGGCGCACGTGGGTGCCCTTCCA
GTTCTACTCCACGCAGTGCCGCAAGATGTACAACCGGCCGCACCGCGCGCCCATCACCAAGCAGAACGAGCAGGAGGCCGTGTGCACCGA
CTCGCACACCGACATGCGCCCGCTCTCGGGCGGCCTCATCGCCTTCAGCACGCTGGACGGGCGGCCCTCGGCGCACGACTTCGACAACTC
GCCCGTGCTGCAGGACTGGGTCACGGCCACAGACATCCGCGTGGCCTTCAGCCGCCTGCACACGTTCGGCGACGAGAACGAGGACGACTC
GGAGCTGGCGCGCGACTCGTACTTCTACGCGGTGTCCGACCTGCAGGTGGGCGGCCGGTGCAAGTGCAACGGCCACGCGGCCCGCTGCGT
GCGCGACCGCGACGACAGCCTGGTGTGCGACTGCAGGCACAACACGGCCGGCCCGGAGTGCGACCGCTGCAAGCCCTTCCACTACGACCG
GCCCTGGCAGCGCGCCACAGCCCGCGAAGCCAACGAGTGCGTGGAGATAATTGACGACCTTGCCAACCTAGTGGAGAACACAGATGAAAA
ACTTCGCAATGAAACCAGGCGGGTAAACATGGTGGACAGAAAGTCAGCCTCTTGTGGGATGATCATGGTGATTTTACTGCTGCTTGTGGC
TATCGTGGTTGTTGCAGTCTGGCCGACCAACTGATGGCAGTAAAGAGACCACCAGCAGTGACACCTGCCAATGACAGATGCAAGCCCAAC

>60673_60673_4_NTN1-STX8_NTN1_chr17_8926708_ENST00000538852_STX8_chr17_9281970_ENST00000574431_length(amino acids)=395AA_BP=339
MMRAVWEALAALAAVACLVGAVRGGPGLSMFAGQAAQPDPCSDENGHPRRCIPDFVNAAFGKDVRVSSTCGRPPARYCVVSERGEERLRS
CHLCNASDPKKAHPPAFLTDLNNPHNLTCWQSENYLQFPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGRTWVPFQFYSTQ
CRKMYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGLIAFSTLDGRPSAHDFDNSPVLQDWVTATDIRVAFSRLHTFGDENEDDSELARD
SYFYAVSDLQVGGRCKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVEIIDDLANLVENTDEKLRNET

--------------------------------------------------------------
>60673_60673_5_NTN1-STX8_NTN1_chr17_8926708_ENST00000546090_STX8_chr17_9281970_ENST00000306357_length(transcript)=1366nt_BP=1089nt
CTCCGCAGGCGCCTTCTGCGGCAGGCGGACAGATCCTCGGCGCGGCAGGGCCGGGGCAAGCTGGACGCAGCATGATGCGCGCAGTGTGGG
AGGCGCTGGCGGCGCTGGCGGCGGTGGCGTGCCTGGTGGGCGCGGTGCGCGGCGGGCCCGGGCTCAGCATGTTCGCGGGCCAGGCGGCGC
AGCCCGATCCCTGCTCGGACGAGAACGGCCACCCGCGCCGCTGCATCCCGGACTTTGTCAATGCGGCCTTCGGCAAGGACGTGCGCGTGT
CCAGCACCTGCGGCCGGCCCCCGGCGCGCTACTGCGTGGTGAGCGAGCGCGGCGAGGAGCGGCTGCGCTCGTGCCACCTCTGCAACGCGT
CCGACCCCAAGAAGGCGCACCCGCCCGCCTTCCTCACCGACCTCAACAACCCGCACAACCTGACGTGCTGGCAGTCCGAGAACTACCTGC
AGTTCCCGCACAACGTCACGCTCACACTGTCCCTCGGCAAGAAGTTCGAAGTGACCTACGTGAGCCTGCAGTTCTGCTCGCCGCGGCCCG
AGTCCATGGCCATCTACAAGTCCATGGACTACGGGCGCACGTGGGTGCCCTTCCAGTTCTACTCCACGCAGTGCCGCAAGATGTACAACC
GGCCGCACCGCGCGCCCATCACCAAGCAGAACGAGCAGGAGGCCGTGTGCACCGACTCGCACACCGACATGCGCCCGCTCTCGGGCGGCC
TCATCGCCTTCAGCACGCTGGACGGGCGGCCCTCGGCGCACGACTTCGACAACTCGCCCGTGCTGCAGGACTGGGTCACGGCCACAGACA
TCCGCGTGGCCTTCAGCCGCCTGCACACGTTCGGCGACGAGAACGAGGACGACTCGGAGCTGGCGCGCGACTCGTACTTCTACGCGGTGT
CCGACCTGCAGGTGGGCGGCCGGTGCAAGTGCAACGGCCACGCGGCCCGCTGCGTGCGCGACCGCGACGACAGCCTGGTGTGCGACTGCA
GGCACAACACGGCCGGCCCGGAGTGCGACCGCTGCAAGCCCTTCCACTACGACCGGCCCTGGCAGCGCGCCACAGCCCGCGAAGCCAACG
AGTGCGTGGAGATAATTGACGACCTTGCCAACCTAGTGGAGAACACAGATGAAAAACTTCGCAATGAAACCAGGCGGGTAAACATGGTGG
ACAGAAAGTCAGCCTCTTGTGGGATGATCATGGTGATTTTACTGCTGCTTGTGGCTATCGTGGTTGTTGCAGTCTGGCCGACCAACTGAT
GGCAGTAAAGAGACCACCAGCAGTGACACCTGCCAATGACAGATGCAAGCCCAACACCCTTTTGGTACGCAAAACCTGCTCTCAATAAAT

>60673_60673_5_NTN1-STX8_NTN1_chr17_8926708_ENST00000546090_STX8_chr17_9281970_ENST00000306357_length(amino acids)=395AA_BP=339
MMRAVWEALAALAAVACLVGAVRGGPGLSMFAGQAAQPDPCSDENGHPRRCIPDFVNAAFGKDVRVSSTCGRPPARYCVVSERGEERLRS
CHLCNASDPKKAHPPAFLTDLNNPHNLTCWQSENYLQFPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGRTWVPFQFYSTQ
CRKMYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGLIAFSTLDGRPSAHDFDNSPVLQDWVTATDIRVAFSRLHTFGDENEDDSELARD
SYFYAVSDLQVGGRCKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVEIIDDLANLVENTDEKLRNET

--------------------------------------------------------------
>60673_60673_6_NTN1-STX8_NTN1_chr17_8926708_ENST00000546090_STX8_chr17_9281970_ENST00000574431_length(transcript)=1350nt_BP=1089nt
CTCCGCAGGCGCCTTCTGCGGCAGGCGGACAGATCCTCGGCGCGGCAGGGCCGGGGCAAGCTGGACGCAGCATGATGCGCGCAGTGTGGG
AGGCGCTGGCGGCGCTGGCGGCGGTGGCGTGCCTGGTGGGCGCGGTGCGCGGCGGGCCCGGGCTCAGCATGTTCGCGGGCCAGGCGGCGC
AGCCCGATCCCTGCTCGGACGAGAACGGCCACCCGCGCCGCTGCATCCCGGACTTTGTCAATGCGGCCTTCGGCAAGGACGTGCGCGTGT
CCAGCACCTGCGGCCGGCCCCCGGCGCGCTACTGCGTGGTGAGCGAGCGCGGCGAGGAGCGGCTGCGCTCGTGCCACCTCTGCAACGCGT
CCGACCCCAAGAAGGCGCACCCGCCCGCCTTCCTCACCGACCTCAACAACCCGCACAACCTGACGTGCTGGCAGTCCGAGAACTACCTGC
AGTTCCCGCACAACGTCACGCTCACACTGTCCCTCGGCAAGAAGTTCGAAGTGACCTACGTGAGCCTGCAGTTCTGCTCGCCGCGGCCCG
AGTCCATGGCCATCTACAAGTCCATGGACTACGGGCGCACGTGGGTGCCCTTCCAGTTCTACTCCACGCAGTGCCGCAAGATGTACAACC
GGCCGCACCGCGCGCCCATCACCAAGCAGAACGAGCAGGAGGCCGTGTGCACCGACTCGCACACCGACATGCGCCCGCTCTCGGGCGGCC
TCATCGCCTTCAGCACGCTGGACGGGCGGCCCTCGGCGCACGACTTCGACAACTCGCCCGTGCTGCAGGACTGGGTCACGGCCACAGACA
TCCGCGTGGCCTTCAGCCGCCTGCACACGTTCGGCGACGAGAACGAGGACGACTCGGAGCTGGCGCGCGACTCGTACTTCTACGCGGTGT
CCGACCTGCAGGTGGGCGGCCGGTGCAAGTGCAACGGCCACGCGGCCCGCTGCGTGCGCGACCGCGACGACAGCCTGGTGTGCGACTGCA
GGCACAACACGGCCGGCCCGGAGTGCGACCGCTGCAAGCCCTTCCACTACGACCGGCCCTGGCAGCGCGCCACAGCCCGCGAAGCCAACG
AGTGCGTGGAGATAATTGACGACCTTGCCAACCTAGTGGAGAACACAGATGAAAAACTTCGCAATGAAACCAGGCGGGTAAACATGGTGG
ACAGAAAGTCAGCCTCTTGTGGGATGATCATGGTGATTTTACTGCTGCTTGTGGCTATCGTGGTTGTTGCAGTCTGGCCGACCAACTGAT
GGCAGTAAAGAGACCACCAGCAGTGACACCTGCCAATGACAGATGCAAGCCCAACACCCTTTTGGTACGCAAAACCTGCTCTCAATAAAT

>60673_60673_6_NTN1-STX8_NTN1_chr17_8926708_ENST00000546090_STX8_chr17_9281970_ENST00000574431_length(amino acids)=395AA_BP=339
MMRAVWEALAALAAVACLVGAVRGGPGLSMFAGQAAQPDPCSDENGHPRRCIPDFVNAAFGKDVRVSSTCGRPPARYCVVSERGEERLRS
CHLCNASDPKKAHPPAFLTDLNNPHNLTCWQSENYLQFPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGRTWVPFQFYSTQ
CRKMYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGLIAFSTLDGRPSAHDFDNSPVLQDWVTATDIRVAFSRLHTFGDENEDDSELARD
SYFYAVSDLQVGGRCKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVEIIDDLANLVENTDEKLRNET

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NTN1-STX8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NTN1-STX8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NTN1-STX8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource