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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGAP32-C20orf24 (FusionGDB2 ID:6068)

Fusion Gene Summary for ARHGAP32-C20orf24

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP32-C20orf24
Fusion gene ID: 6068
HgeneTgene
Gene symbol

ARHGAP32

C20orf24

Gene ID

9743

55969

Gene nameRho GTPase activating protein 32RAB5 interacting factor
SynonymsGC-GAP|GRIT|PX-RICS|RICS|p200RhoGAP|p250GAPC20orf24|PNAS-11|RCAF1|RIP5
Cytomap

11q24.3

20q11.23

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 32GAB-associated CDC42GAB-associated Cdc42/Rac GTPase-activating proteinGTPase regulator interacting with TrkAGTPase-activating protein for Cdc42 and Rac1RhoGAP involved in the -catenin-N-cadherin and NMDA receptor signauncharacterized protein RAB5IFrab5-interacting proteinrespirasome complex assembly factor 1uncharacterized protein C20orf24
Modification date2020032720200313
UniProtAcc

A7KAX9

.
Ensembl transtripts involved in fusion geneENST00000310343, ENST00000524655, 
ENST00000392657, ENST00000527272, 
ENST00000342422, ENST00000344795, 
ENST00000373852, 
Fusion gene scores* DoF score10 X 9 X 5=4507 X 7 X 4=196
# samples 117
** MAII scorelog2(11/450*10)=-2.03242147769238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP32 [Title/Abstract] AND C20orf24 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP32(128932175)-C20orf24(35236118), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARHGAP32 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across C20orf24 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-EW-A2FW-01AARHGAP32chr11

128932175

-C20orf24chr20

35236118

+


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Fusion Gene ORF analysis for ARHGAP32-C20orf24

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000310343ENST00000342422ARHGAP32chr11

128932175

-C20orf24chr20

35236118

+
In-frameENST00000310343ENST00000344795ARHGAP32chr11

128932175

-C20orf24chr20

35236118

+
In-frameENST00000310343ENST00000373852ARHGAP32chr11

128932175

-C20orf24chr20

35236118

+
In-frameENST00000524655ENST00000342422ARHGAP32chr11

128932175

-C20orf24chr20

35236118

+
In-frameENST00000524655ENST00000344795ARHGAP32chr11

128932175

-C20orf24chr20

35236118

+
In-frameENST00000524655ENST00000373852ARHGAP32chr11

128932175

-C20orf24chr20

35236118

+
intron-3CDSENST00000392657ENST00000342422ARHGAP32chr11

128932175

-C20orf24chr20

35236118

+
intron-3CDSENST00000392657ENST00000344795ARHGAP32chr11

128932175

-C20orf24chr20

35236118

+
intron-3CDSENST00000392657ENST00000373852ARHGAP32chr11

128932175

-C20orf24chr20

35236118

+
intron-3CDSENST00000527272ENST00000342422ARHGAP32chr11

128932175

-C20orf24chr20

35236118

+
intron-3CDSENST00000527272ENST00000344795ARHGAP32chr11

128932175

-C20orf24chr20

35236118

+
intron-3CDSENST00000527272ENST00000373852ARHGAP32chr11

128932175

-C20orf24chr20

35236118

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000310343ARHGAP32chr11128932175-ENST00000344795C20orf24chr2035236118+170392101196398
ENST00000310343ARHGAP32chr11128932175-ENST00000373852C20orf24chr2035236118+173192101220406
ENST00000310343ARHGAP32chr11128932175-ENST00000342422C20orf24chr2035236118+157392101238412
ENST00000524655ARHGAP32chr11128932175-ENST00000344795C20orf24chr2035236118+150572324998324
ENST00000524655ARHGAP32chr11128932175-ENST00000373852C20orf24chr2035236118+1533723241022332
ENST00000524655ARHGAP32chr11128932175-ENST00000342422C20orf24chr2035236118+1375723241040338

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000310343ENST00000344795ARHGAP32chr11128932175-C20orf24chr2035236118+0.0001703590.99982965
ENST00000310343ENST00000373852ARHGAP32chr11128932175-C20orf24chr2035236118+0.0001543660.9998456
ENST00000310343ENST00000342422ARHGAP32chr11128932175-C20orf24chr2035236118+0.0001919560.999808
ENST00000524655ENST00000344795ARHGAP32chr11128932175-C20orf24chr2035236118+0.0003459530.99965405
ENST00000524655ENST00000373852ARHGAP32chr11128932175-C20orf24chr2035236118+0.0002915410.9997085
ENST00000524655ENST00000342422ARHGAP32chr11128932175-C20orf24chr2035236118+0.000428460.9995715

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Fusion Genomic Features for ARHGAP32-C20orf24


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARHGAP32chr11128932174-C20orf24chr2035236117+1.21E-070.9999999
ARHGAP32chr11128932174-C20orf24chr2035236117+1.21E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARHGAP32-C20orf24


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:128932175/chr20:35236118)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP32

A7KAX9

.
FUNCTION: GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP32chr11:128932175chr20:35236118ENST00000310343-922131_2453072088.0DomainNote=PX%3B atypical
TgeneC20orf24chr11:128932175chr20:35236118ENST000003424220345_6438144.0TransmembraneHelical
TgeneC20orf24chr11:128932175chr20:35236118ENST000003424220368_9038144.0TransmembraneHelical
TgeneC20orf24chr11:128932175chr20:35236118ENST000003447950445_6438130.0TransmembraneHelical
TgeneC20orf24chr11:128932175chr20:35236118ENST000003447950468_9038130.0TransmembraneHelical
TgeneC20orf24chr11:128932175chr20:35236118ENST000003738520445_6438138.0TransmembraneHelical
TgeneC20orf24chr11:128932175chr20:35236118ENST000003738520468_9038138.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP32chr11:128932175chr20:35236118ENST00000310343-9221031_10363072088.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128932175chr20:35236118ENST00000310343-9221305_13103072088.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128932175chr20:35236118ENST00000392657-1131031_103601739.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128932175chr20:35236118ENST00000392657-1131305_131001739.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128932175chr20:35236118ENST00000527272-1121031_103601739.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128932175chr20:35236118ENST00000527272-1121305_131001739.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128932175chr20:35236118ENST00000310343-922259_3213072088.0DomainSH3
HgeneARHGAP32chr11:128932175chr20:35236118ENST00000310343-922372_5673072088.0DomainRho-GAP
HgeneARHGAP32chr11:128932175chr20:35236118ENST00000392657-113131_24501739.0DomainNote=PX%3B atypical
HgeneARHGAP32chr11:128932175chr20:35236118ENST00000392657-113259_32101739.0DomainSH3
HgeneARHGAP32chr11:128932175chr20:35236118ENST00000392657-113372_56701739.0DomainRho-GAP
HgeneARHGAP32chr11:128932175chr20:35236118ENST00000527272-112131_24501739.0DomainNote=PX%3B atypical
HgeneARHGAP32chr11:128932175chr20:35236118ENST00000527272-112259_32101739.0DomainSH3
HgeneARHGAP32chr11:128932175chr20:35236118ENST00000527272-112372_56701739.0DomainRho-GAP


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Fusion Gene Sequence for ARHGAP32-C20orf24


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6068_6068_1_ARHGAP32-C20orf24_ARHGAP32_chr11_128932175_ENST00000310343_C20orf24_chr20_35236118_ENST00000342422_length(transcript)=1573nt_BP=921nt
ATGGAGACTGAAAGTGAGAGTAGCACTTTAGGGGATGACAGTGTCTTCTGGTTGGAGTCTGAAGTTATAATCCAGGTGACTGACTGTGAA
GAGGAAGAAAGGGAAGAGAAGTTCAGGAAGATGAAGTCCTCAGTACATTCTGAAGAAGATGATTTTGTTCCAGAGCTACATAGAAATGTA
CACCCTCGAGAGCGGCCTGATTGGGAAGAAACTCTTAGCGCAATGGCAAGAGGCGCAGATGTTCCAGAGATTCCTGGAGATCTTACTCTT
AAGACGTGTGGCAGTACAGCCAGTATGAAGGTTAAGCATGTGAAAAAGTTACCCTTCACTAAAGGTCACTTTCCGAAGATGGCTGAATGT
GCGCATTTCCATTATGAGAATGTTGAGTTCGGCAGCATACAGCTTTCACTTTCAGAAGAACAGAATGAAGTAATGAAAAATGGCTGTGAA
TCTAAAGAGCTGGTCTACCTCGTGCAGATTGCTTGTCAGGGAAAAAGTTGGATTGTTAAAAGAAGTTATGAAGATTTTCGGGTACTTGAT
AAACATCTTCATCTGTGTATTTATGACCGAAGATTTTCCCAGCTCTCAGAACTTCCCCGTTCTGACACCCTGAAGGACAGTCCAGAGTCG
GTCACTCAGATGCTTATGGCTTACCTGTCACGCCTTTCAGCTATCGCTGGCAACAAGATCAACTGTGGGCCCGCCCTTACCTGGATGGAG
ATTGATAATAAGGGAAATCACCTTTTGGTTCATGAGGAGTCATCCATCAACACTCCTGCTGTCGGTGCTGCCCATGTTATCAAGAGGTAC
ACTGCTCGGGCCCCTGACGAACTGACCTTAGAGGTGGGAGACATTGTTTCTGTTATTGACATGCCCCCGAAAGTGTTAAGCACATGGTGG
AGAGGCAAGCACGGATTCCAGGATGAATTTTTAGATGTGATCTACTGGTTCCGACAGATCATTGCTGTGGTCCTGGGTGTCATTTGGGGA
GTTTTGCCATTACGAGGGTTCTTGGGAATAGCAGGGTCATTTGGATCATCTTTTACACTGCCATCCATTATGACTGATGGTGTACAGCTC
CCAAGTGCTCCCTATCCAGTCCAAAGGACCCTCTTGATTACAGCACAGGAACTTGATCGTTGGGGAACCCCAGCCCCTTGGAACTTGGAA
GACCCGTGTTTCCTGGACCGCGAATCAGTGTGTTGGGCATCAGTGTTTTCTGCAAGGGTTGTGACCTGAAACTTTTTAAAAACCACCCAC
CTTTGGGGAAGCATTTCTGAATTTATCCATCACCAACCATTTCTTCTTGGATACCATCAAGTAACAGCTATTATTTGCCAAGTGGAGCTG
TCATTTAATTTGATGCACCTCTGGATTCAGATGAAACATTAAATTGTCTTCCTCGATTCTCCATCGGGTGTAGAGTTTTTAAACTATCAA
TGGCATTTCAAGTCTTCTGAAACAGCATGGCTGTATGTGCGTGGTCCATAGCACAGTACATGCAGCATCTAATAAGAGTTTCCATTGTAG

>6068_6068_1_ARHGAP32-C20orf24_ARHGAP32_chr11_128932175_ENST00000310343_C20orf24_chr20_35236118_ENST00000342422_length(amino acids)=412AA_BP=306
METESESSTLGDDSVFWLESEVIIQVTDCEEEEREEKFRKMKSSVHSEEDDFVPELHRNVHPRERPDWEETLSAMARGADVPEIPGDLTL
KTCGSTASMKVKHVKKLPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQGKSWIVKRSYEDFRVLD
KHLHLCIYDRRFSQLSELPRSDTLKDSPESVTQMLMAYLSRLSAIAGNKINCGPALTWMEIDNKGNHLLVHEESSINTPAVGAAHVIKRY
TARAPDELTLEVGDIVSVIDMPPKVLSTWWRGKHGFQDEFLDVIYWFRQIIAVVLGVIWGVLPLRGFLGIAGSFGSSFTLPSIMTDGVQL

--------------------------------------------------------------
>6068_6068_2_ARHGAP32-C20orf24_ARHGAP32_chr11_128932175_ENST00000310343_C20orf24_chr20_35236118_ENST00000344795_length(transcript)=1703nt_BP=921nt
ATGGAGACTGAAAGTGAGAGTAGCACTTTAGGGGATGACAGTGTCTTCTGGTTGGAGTCTGAAGTTATAATCCAGGTGACTGACTGTGAA
GAGGAAGAAAGGGAAGAGAAGTTCAGGAAGATGAAGTCCTCAGTACATTCTGAAGAAGATGATTTTGTTCCAGAGCTACATAGAAATGTA
CACCCTCGAGAGCGGCCTGATTGGGAAGAAACTCTTAGCGCAATGGCAAGAGGCGCAGATGTTCCAGAGATTCCTGGAGATCTTACTCTT
AAGACGTGTGGCAGTACAGCCAGTATGAAGGTTAAGCATGTGAAAAAGTTACCCTTCACTAAAGGTCACTTTCCGAAGATGGCTGAATGT
GCGCATTTCCATTATGAGAATGTTGAGTTCGGCAGCATACAGCTTTCACTTTCAGAAGAACAGAATGAAGTAATGAAAAATGGCTGTGAA
TCTAAAGAGCTGGTCTACCTCGTGCAGATTGCTTGTCAGGGAAAAAGTTGGATTGTTAAAAGAAGTTATGAAGATTTTCGGGTACTTGAT
AAACATCTTCATCTGTGTATTTATGACCGAAGATTTTCCCAGCTCTCAGAACTTCCCCGTTCTGACACCCTGAAGGACAGTCCAGAGTCG
GTCACTCAGATGCTTATGGCTTACCTGTCACGCCTTTCAGCTATCGCTGGCAACAAGATCAACTGTGGGCCCGCCCTTACCTGGATGGAG
ATTGATAATAAGGGAAATCACCTTTTGGTTCATGAGGAGTCATCCATCAACACTCCTGCTGTCGGTGCTGCCCATGTTATCAAGAGGTAC
ACTGCTCGGGCCCCTGACGAACTGACCTTAGAGGTGGGAGACATTGTTTCTGTTATTGACATGCCCCCGAAAGTGTTAAGCACATGGTGG
AGAGGCAAGCACGGATTCCAGGATGAATTTTTAGATGTGATCTACTGGTTCCGACAGATCATTGCTGTGGTCCTGGGTGTCATTTGGGGA
GTTTTGCCATTACGAGGGTTCTTGGGAATAGCAGGATTCTGCCTGATCAATGCAGGAGTCCTGTACCTCTACTTCAGCAATTACCTACAG
ATTGATGAGGAAGAATATGGTGGCACGTGGGAGCTCACGAAGGAAGGGTTTATGACCTCTTTTGCCTTGTTCATGGTCATTTGGATCATC
TTTTACACTGCCATCCATTATGACTGATGGTGTACAGCTCCCAAGTGCTCCCTATCCAGTCCAAAGGACCCTCTTGATTACAGCACAGGA
ACTTGATCGTTGGGGAACCCCAGCCCCTTGGAACTTGGAAGACCCGTGTTTCCTGGACCGCGAATCAGTGTGTTGGGCATCAGTGTTTTC
TGCAAGGGTTGTGACCTGAAACTTTTTAAAAACCACCCACCTTTGGGGAAGCATTTCTGAATTTATCCATCACCAACCATTTCTTCTTGG
ATACCATCAAGTAACAGCTATTATTTGCCAAGTGGAGCTGTCATTTAATTTGATGCACCTCTGGATTCAGATGAAACATTAAATTGTCTT
CCTCGATTCTCCATCGGGTGTAGAGTTTTTAAACTATCAATGGCATTTCAAGTCTTCTGAAACAGCATGGCTGTATGTGCGTGGTCCATA

>6068_6068_2_ARHGAP32-C20orf24_ARHGAP32_chr11_128932175_ENST00000310343_C20orf24_chr20_35236118_ENST00000344795_length(amino acids)=398AA_BP=306
METESESSTLGDDSVFWLESEVIIQVTDCEEEEREEKFRKMKSSVHSEEDDFVPELHRNVHPRERPDWEETLSAMARGADVPEIPGDLTL
KTCGSTASMKVKHVKKLPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQGKSWIVKRSYEDFRVLD
KHLHLCIYDRRFSQLSELPRSDTLKDSPESVTQMLMAYLSRLSAIAGNKINCGPALTWMEIDNKGNHLLVHEESSINTPAVGAAHVIKRY
TARAPDELTLEVGDIVSVIDMPPKVLSTWWRGKHGFQDEFLDVIYWFRQIIAVVLGVIWGVLPLRGFLGIAGFCLINAGVLYLYFSNYLQ

--------------------------------------------------------------
>6068_6068_3_ARHGAP32-C20orf24_ARHGAP32_chr11_128932175_ENST00000310343_C20orf24_chr20_35236118_ENST00000373852_length(transcript)=1731nt_BP=921nt
ATGGAGACTGAAAGTGAGAGTAGCACTTTAGGGGATGACAGTGTCTTCTGGTTGGAGTCTGAAGTTATAATCCAGGTGACTGACTGTGAA
GAGGAAGAAAGGGAAGAGAAGTTCAGGAAGATGAAGTCCTCAGTACATTCTGAAGAAGATGATTTTGTTCCAGAGCTACATAGAAATGTA
CACCCTCGAGAGCGGCCTGATTGGGAAGAAACTCTTAGCGCAATGGCAAGAGGCGCAGATGTTCCAGAGATTCCTGGAGATCTTACTCTT
AAGACGTGTGGCAGTACAGCCAGTATGAAGGTTAAGCATGTGAAAAAGTTACCCTTCACTAAAGGTCACTTTCCGAAGATGGCTGAATGT
GCGCATTTCCATTATGAGAATGTTGAGTTCGGCAGCATACAGCTTTCACTTTCAGAAGAACAGAATGAAGTAATGAAAAATGGCTGTGAA
TCTAAAGAGCTGGTCTACCTCGTGCAGATTGCTTGTCAGGGAAAAAGTTGGATTGTTAAAAGAAGTTATGAAGATTTTCGGGTACTTGAT
AAACATCTTCATCTGTGTATTTATGACCGAAGATTTTCCCAGCTCTCAGAACTTCCCCGTTCTGACACCCTGAAGGACAGTCCAGAGTCG
GTCACTCAGATGCTTATGGCTTACCTGTCACGCCTTTCAGCTATCGCTGGCAACAAGATCAACTGTGGGCCCGCCCTTACCTGGATGGAG
ATTGATAATAAGGGAAATCACCTTTTGGTTCATGAGGAGTCATCCATCAACACTCCTGCTGTCGGTGCTGCCCATGTTATCAAGAGGTAC
ACTGCTCGGGCCCCTGACGAACTGACCTTAGAGGTGGGAGACATTGTTTCTGTTATTGACATGCCCCCGAAAGTGTTAAGCACATGGTGG
AGAGGCAAGCACGGATTCCAGGATGAATTTTTAGATGTGATCTACTGGTTCCGACAGATCATTGCTGTGGTCCTGGGTGTCATTTGGGGA
GTTTTGCCATTACGAGGGTTCTTGGGAATAGCAGGATTCTGCCTGATCAATGCAGGAGTCCTGTACCTCTACTTCAGCAATTACCTACAG
ATTGATGAGGAAGAATATGGTGGCACGTGGGAGCTCACGAAGGAAGGGTTTATGACCTCTTTTGCCTTGTTCATGGTATGTGTAGCTGAT
AGTTTTACAACAGGTCATTTGGATCATCTTTTACACTGCCATCCATTATGACTGATGGTGTACAGCTCCCAAGTGCTCCCTATCCAGTCC
AAAGGACCCTCTTGATTACAGCACAGGAACTTGATCGTTGGGGAACCCCAGCCCCTTGGAACTTGGAAGACCCGTGTTTCCTGGACCGCG
AATCAGTGTGTTGGGCATCAGTGTTTTCTGCAAGGGTTGTGACCTGAAACTTTTTAAAAACCACCCACCTTTGGGGAAGCATTTCTGAAT
TTATCCATCACCAACCATTTCTTCTTGGATACCATCAAGTAACAGCTATTATTTGCCAAGTGGAGCTGTCATTTAATTTGATGCACCTCT
GGATTCAGATGAAACATTAAATTGTCTTCCTCGATTCTCCATCGGGTGTAGAGTTTTTAAACTATCAATGGCATTTCAAGTCTTCTGAAA
CAGCATGGCTGTATGTGCGTGGTCCATAGCACAGTACATGCAGCATCTAATAAGAGTTTCCATTGTAGAATGTTTTCACATACTTGAATA

>6068_6068_3_ARHGAP32-C20orf24_ARHGAP32_chr11_128932175_ENST00000310343_C20orf24_chr20_35236118_ENST00000373852_length(amino acids)=406AA_BP=306
METESESSTLGDDSVFWLESEVIIQVTDCEEEEREEKFRKMKSSVHSEEDDFVPELHRNVHPRERPDWEETLSAMARGADVPEIPGDLTL
KTCGSTASMKVKHVKKLPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQGKSWIVKRSYEDFRVLD
KHLHLCIYDRRFSQLSELPRSDTLKDSPESVTQMLMAYLSRLSAIAGNKINCGPALTWMEIDNKGNHLLVHEESSINTPAVGAAHVIKRY
TARAPDELTLEVGDIVSVIDMPPKVLSTWWRGKHGFQDEFLDVIYWFRQIIAVVLGVIWGVLPLRGFLGIAGFCLINAGVLYLYFSNYLQ

--------------------------------------------------------------
>6068_6068_4_ARHGAP32-C20orf24_ARHGAP32_chr11_128932175_ENST00000524655_C20orf24_chr20_35236118_ENST00000342422_length(transcript)=1375nt_BP=723nt
GATTGGGAAGAAACTCTTAGCGCAATGGCAAGAGGCGCAGATGTTCCAGAGATTCCTGGAGATCTTACTCTTAAGACGTGTGGCAGTACA
GCCAGTATGAAGGTTAAGCATGTGAAAAAGTTACCCTTCACTAAAGGTCACTTTCCGAAGATGGCTGAATGTGCGCATTTCCATTATGAG
AATGTTGAGTTCGGCAGCATACAGCTTTCACTTTCAGAAGAACAGAATGAAGTAATGAAAAATGGCTGTGAATCTAAAGAGCTGGTCTAC
CTCGTGCAGATTGCTTGTCAGGGAAAAAGTTGGATTGTTAAAAGAAGTTATGAAGATTTTCGGGTACTTGATAAACATCTTCATCTGTGT
ATTTATGACCGAAGATTTTCCCAGCTCTCAGAACTTCCCCGTTCTGACACCCTGAAGGACAGTCCAGAGTCGGTCACTCAGATGCTTATG
GCTTACCTGTCACGCCTTTCAGCTATCGCTGGCAACAAGATCAACTGTGGGCCCGCCCTTACCTGGATGGAGATTGATAATAAGGGAAAT
CACCTTTTGGTTCATGAGGAGTCATCCATCAACACTCCTGCTGTCGGTGCTGCCCATGTTATCAAGAGGTACACTGCTCGGGCCCCTGAC
GAACTGACCTTAGAGGTGGGAGACATTGTTTCTGTTATTGACATGCCCCCGAAAGTGTTAAGCACATGGTGGAGAGGCAAGCACGGATTC
CAGGATGAATTTTTAGATGTGATCTACTGGTTCCGACAGATCATTGCTGTGGTCCTGGGTGTCATTTGGGGAGTTTTGCCATTACGAGGG
TTCTTGGGAATAGCAGGGTCATTTGGATCATCTTTTACACTGCCATCCATTATGACTGATGGTGTACAGCTCCCAAGTGCTCCCTATCCA
GTCCAAAGGACCCTCTTGATTACAGCACAGGAACTTGATCGTTGGGGAACCCCAGCCCCTTGGAACTTGGAAGACCCGTGTTTCCTGGAC
CGCGAATCAGTGTGTTGGGCATCAGTGTTTTCTGCAAGGGTTGTGACCTGAAACTTTTTAAAAACCACCCACCTTTGGGGAAGCATTTCT
GAATTTATCCATCACCAACCATTTCTTCTTGGATACCATCAAGTAACAGCTATTATTTGCCAAGTGGAGCTGTCATTTAATTTGATGCAC
CTCTGGATTCAGATGAAACATTAAATTGTCTTCCTCGATTCTCCATCGGGTGTAGAGTTTTTAAACTATCAATGGCATTTCAAGTCTTCT
GAAACAGCATGGCTGTATGTGCGTGGTCCATAGCACAGTACATGCAGCATCTAATAAGAGTTTCCATTGTAGAATGTTTTCACATACTTG

>6068_6068_4_ARHGAP32-C20orf24_ARHGAP32_chr11_128932175_ENST00000524655_C20orf24_chr20_35236118_ENST00000342422_length(amino acids)=338AA_BP=232
MARGADVPEIPGDLTLKTCGSTASMKVKHVKKLPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQG
KSWIVKRSYEDFRVLDKHLHLCIYDRRFSQLSELPRSDTLKDSPESVTQMLMAYLSRLSAIAGNKINCGPALTWMEIDNKGNHLLVHEES
SINTPAVGAAHVIKRYTARAPDELTLEVGDIVSVIDMPPKVLSTWWRGKHGFQDEFLDVIYWFRQIIAVVLGVIWGVLPLRGFLGIAGSF

--------------------------------------------------------------
>6068_6068_5_ARHGAP32-C20orf24_ARHGAP32_chr11_128932175_ENST00000524655_C20orf24_chr20_35236118_ENST00000344795_length(transcript)=1505nt_BP=723nt
GATTGGGAAGAAACTCTTAGCGCAATGGCAAGAGGCGCAGATGTTCCAGAGATTCCTGGAGATCTTACTCTTAAGACGTGTGGCAGTACA
GCCAGTATGAAGGTTAAGCATGTGAAAAAGTTACCCTTCACTAAAGGTCACTTTCCGAAGATGGCTGAATGTGCGCATTTCCATTATGAG
AATGTTGAGTTCGGCAGCATACAGCTTTCACTTTCAGAAGAACAGAATGAAGTAATGAAAAATGGCTGTGAATCTAAAGAGCTGGTCTAC
CTCGTGCAGATTGCTTGTCAGGGAAAAAGTTGGATTGTTAAAAGAAGTTATGAAGATTTTCGGGTACTTGATAAACATCTTCATCTGTGT
ATTTATGACCGAAGATTTTCCCAGCTCTCAGAACTTCCCCGTTCTGACACCCTGAAGGACAGTCCAGAGTCGGTCACTCAGATGCTTATG
GCTTACCTGTCACGCCTTTCAGCTATCGCTGGCAACAAGATCAACTGTGGGCCCGCCCTTACCTGGATGGAGATTGATAATAAGGGAAAT
CACCTTTTGGTTCATGAGGAGTCATCCATCAACACTCCTGCTGTCGGTGCTGCCCATGTTATCAAGAGGTACACTGCTCGGGCCCCTGAC
GAACTGACCTTAGAGGTGGGAGACATTGTTTCTGTTATTGACATGCCCCCGAAAGTGTTAAGCACATGGTGGAGAGGCAAGCACGGATTC
CAGGATGAATTTTTAGATGTGATCTACTGGTTCCGACAGATCATTGCTGTGGTCCTGGGTGTCATTTGGGGAGTTTTGCCATTACGAGGG
TTCTTGGGAATAGCAGGATTCTGCCTGATCAATGCAGGAGTCCTGTACCTCTACTTCAGCAATTACCTACAGATTGATGAGGAAGAATAT
GGTGGCACGTGGGAGCTCACGAAGGAAGGGTTTATGACCTCTTTTGCCTTGTTCATGGTCATTTGGATCATCTTTTACACTGCCATCCAT
TATGACTGATGGTGTACAGCTCCCAAGTGCTCCCTATCCAGTCCAAAGGACCCTCTTGATTACAGCACAGGAACTTGATCGTTGGGGAAC
CCCAGCCCCTTGGAACTTGGAAGACCCGTGTTTCCTGGACCGCGAATCAGTGTGTTGGGCATCAGTGTTTTCTGCAAGGGTTGTGACCTG
AAACTTTTTAAAAACCACCCACCTTTGGGGAAGCATTTCTGAATTTATCCATCACCAACCATTTCTTCTTGGATACCATCAAGTAACAGC
TATTATTTGCCAAGTGGAGCTGTCATTTAATTTGATGCACCTCTGGATTCAGATGAAACATTAAATTGTCTTCCTCGATTCTCCATCGGG
TGTAGAGTTTTTAAACTATCAATGGCATTTCAAGTCTTCTGAAACAGCATGGCTGTATGTGCGTGGTCCATAGCACAGTACATGCAGCAT

>6068_6068_5_ARHGAP32-C20orf24_ARHGAP32_chr11_128932175_ENST00000524655_C20orf24_chr20_35236118_ENST00000344795_length(amino acids)=324AA_BP=232
MARGADVPEIPGDLTLKTCGSTASMKVKHVKKLPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQG
KSWIVKRSYEDFRVLDKHLHLCIYDRRFSQLSELPRSDTLKDSPESVTQMLMAYLSRLSAIAGNKINCGPALTWMEIDNKGNHLLVHEES
SINTPAVGAAHVIKRYTARAPDELTLEVGDIVSVIDMPPKVLSTWWRGKHGFQDEFLDVIYWFRQIIAVVLGVIWGVLPLRGFLGIAGFC

--------------------------------------------------------------
>6068_6068_6_ARHGAP32-C20orf24_ARHGAP32_chr11_128932175_ENST00000524655_C20orf24_chr20_35236118_ENST00000373852_length(transcript)=1533nt_BP=723nt
GATTGGGAAGAAACTCTTAGCGCAATGGCAAGAGGCGCAGATGTTCCAGAGATTCCTGGAGATCTTACTCTTAAGACGTGTGGCAGTACA
GCCAGTATGAAGGTTAAGCATGTGAAAAAGTTACCCTTCACTAAAGGTCACTTTCCGAAGATGGCTGAATGTGCGCATTTCCATTATGAG
AATGTTGAGTTCGGCAGCATACAGCTTTCACTTTCAGAAGAACAGAATGAAGTAATGAAAAATGGCTGTGAATCTAAAGAGCTGGTCTAC
CTCGTGCAGATTGCTTGTCAGGGAAAAAGTTGGATTGTTAAAAGAAGTTATGAAGATTTTCGGGTACTTGATAAACATCTTCATCTGTGT
ATTTATGACCGAAGATTTTCCCAGCTCTCAGAACTTCCCCGTTCTGACACCCTGAAGGACAGTCCAGAGTCGGTCACTCAGATGCTTATG
GCTTACCTGTCACGCCTTTCAGCTATCGCTGGCAACAAGATCAACTGTGGGCCCGCCCTTACCTGGATGGAGATTGATAATAAGGGAAAT
CACCTTTTGGTTCATGAGGAGTCATCCATCAACACTCCTGCTGTCGGTGCTGCCCATGTTATCAAGAGGTACACTGCTCGGGCCCCTGAC
GAACTGACCTTAGAGGTGGGAGACATTGTTTCTGTTATTGACATGCCCCCGAAAGTGTTAAGCACATGGTGGAGAGGCAAGCACGGATTC
CAGGATGAATTTTTAGATGTGATCTACTGGTTCCGACAGATCATTGCTGTGGTCCTGGGTGTCATTTGGGGAGTTTTGCCATTACGAGGG
TTCTTGGGAATAGCAGGATTCTGCCTGATCAATGCAGGAGTCCTGTACCTCTACTTCAGCAATTACCTACAGATTGATGAGGAAGAATAT
GGTGGCACGTGGGAGCTCACGAAGGAAGGGTTTATGACCTCTTTTGCCTTGTTCATGGTATGTGTAGCTGATAGTTTTACAACAGGTCAT
TTGGATCATCTTTTACACTGCCATCCATTATGACTGATGGTGTACAGCTCCCAAGTGCTCCCTATCCAGTCCAAAGGACCCTCTTGATTA
CAGCACAGGAACTTGATCGTTGGGGAACCCCAGCCCCTTGGAACTTGGAAGACCCGTGTTTCCTGGACCGCGAATCAGTGTGTTGGGCAT
CAGTGTTTTCTGCAAGGGTTGTGACCTGAAACTTTTTAAAAACCACCCACCTTTGGGGAAGCATTTCTGAATTTATCCATCACCAACCAT
TTCTTCTTGGATACCATCAAGTAACAGCTATTATTTGCCAAGTGGAGCTGTCATTTAATTTGATGCACCTCTGGATTCAGATGAAACATT
AAATTGTCTTCCTCGATTCTCCATCGGGTGTAGAGTTTTTAAACTATCAATGGCATTTCAAGTCTTCTGAAACAGCATGGCTGTATGTGC
GTGGTCCATAGCACAGTACATGCAGCATCTAATAAGAGTTTCCATTGTAGAATGTTTTCACATACTTGAATAAATCAAATCTTTAATTGA

>6068_6068_6_ARHGAP32-C20orf24_ARHGAP32_chr11_128932175_ENST00000524655_C20orf24_chr20_35236118_ENST00000373852_length(amino acids)=332AA_BP=232
MARGADVPEIPGDLTLKTCGSTASMKVKHVKKLPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQG
KSWIVKRSYEDFRVLDKHLHLCIYDRRFSQLSELPRSDTLKDSPESVTQMLMAYLSRLSAIAGNKINCGPALTWMEIDNKGNHLLVHEES
SINTPAVGAAHVIKRYTARAPDELTLEVGDIVSVIDMPPKVLSTWWRGKHGFQDEFLDVIYWFRQIIAVVLGVIWGVLPLRGFLGIAGFC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARHGAP32-C20orf24


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneARHGAP32chr11:128932175chr20:35236118ENST00000310343-9221685_2087307.02088.0FYN
HgeneARHGAP32chr11:128932175chr20:35236118ENST00000392657-1131685_208701739.0FYN
HgeneARHGAP32chr11:128932175chr20:35236118ENST00000527272-1121685_208701739.0FYN
HgeneARHGAP32chr11:128932175chr20:35236118ENST00000310343-9221391_1711307.02088.0GAB2
HgeneARHGAP32chr11:128932175chr20:35236118ENST00000392657-1131391_171101739.0GAB2
HgeneARHGAP32chr11:128932175chr20:35236118ENST00000527272-1121391_171101739.0GAB2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGAP32-C20orf24


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGAP32-C20orf24


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource