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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NTN4-NUP107 (FusionGDB2 ID:60681)

Fusion Gene Summary for NTN4-NUP107

check button Fusion gene summary
Fusion gene informationFusion gene name: NTN4-NUP107
Fusion gene ID: 60681
HgeneTgene
Gene symbol

NTN4

NUP107

Gene ID

59277

57122

Gene namenetrin 4nucleoporin 107
SynonymsPRO3091NPHS11|NUP84|ODG6|ODG6; GAMOS7
Cytomap

12q22

12q15

Type of geneprotein-codingprotein-coding
Descriptionnetrin-4beta-netrinhepar-derived netrin-like proteinnuclear pore complex protein Nup107nucleoporin 107kDa
Modification date2020031320200313
UniProtAcc.

P57740

Ensembl transtripts involved in fusion geneENST00000343702, ENST00000344911, 
ENST00000538383, ENST00000553059, 
ENST00000552603, 		ENST00000401003, 
ENST00000229179, ENST00000378905, 
ENST00000539906, 
Fusion gene scores* DoF score11 X 10 X 5=55027 X 22 X 9=5346
# samples 1137
** MAII scorelog2(11/550*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(37/5346*10)=-3.85286266172677
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NTN4 [Title/Abstract] AND NUP107 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNTN4(96131644)-NUP107(69135593), # samples:3
Anticipated loss of major functional domain due to fusion event.NTN4-NUP107 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NTN4-NUP107 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNUP107

GO:0006406

mRNA export from nucleus

11684705


check buttonFusion gene breakpoints across NTN4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NUP107 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A3M1-01ANTN4chr12

96131644

-NUP107chr12

69135593

+


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Fusion Gene ORF analysis for NTN4-NUP107

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000343702ENST00000401003NTN4chr12

96131644

-NUP107chr12

69135593

+
5CDS-intronENST00000344911ENST00000401003NTN4chr12

96131644

-NUP107chr12

69135593

+
5CDS-intronENST00000538383ENST00000401003NTN4chr12

96131644

-NUP107chr12

69135593

+
5CDS-intronENST00000553059ENST00000401003NTN4chr12

96131644

-NUP107chr12

69135593

+
5UTR-3CDSENST00000552603ENST00000229179NTN4chr12

96131644

-NUP107chr12

69135593

+
5UTR-3CDSENST00000552603ENST00000378905NTN4chr12

96131644

-NUP107chr12

69135593

+
5UTR-3CDSENST00000552603ENST00000539906NTN4chr12

96131644

-NUP107chr12

69135593

+
5UTR-intronENST00000552603ENST00000401003NTN4chr12

96131644

-NUP107chr12

69135593

+
Frame-shiftENST00000538383ENST00000229179NTN4chr12

96131644

-NUP107chr12

69135593

+
Frame-shiftENST00000538383ENST00000378905NTN4chr12

96131644

-NUP107chr12

69135593

+
Frame-shiftENST00000538383ENST00000539906NTN4chr12

96131644

-NUP107chr12

69135593

+
In-frameENST00000343702ENST00000229179NTN4chr12

96131644

-NUP107chr12

69135593

+
In-frameENST00000343702ENST00000378905NTN4chr12

96131644

-NUP107chr12

69135593

+
In-frameENST00000343702ENST00000539906NTN4chr12

96131644

-NUP107chr12

69135593

+
In-frameENST00000344911ENST00000229179NTN4chr12

96131644

-NUP107chr12

69135593

+
In-frameENST00000344911ENST00000378905NTN4chr12

96131644

-NUP107chr12

69135593

+
In-frameENST00000344911ENST00000539906NTN4chr12

96131644

-NUP107chr12

69135593

+
In-frameENST00000553059ENST00000229179NTN4chr12

96131644

-NUP107chr12

69135593

+
In-frameENST00000553059ENST00000378905NTN4chr12

96131644

-NUP107chr12

69135593

+
In-frameENST00000553059ENST00000539906NTN4chr12

96131644

-NUP107chr12

69135593

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000343702NTN4chr1296131644-ENST00000229179NUP107chr1269135593+213213131131588491
ENST00000343702NTN4chr1296131644-ENST00000378905NUP107chr1269135593+181013131131588491
ENST00000343702NTN4chr1296131644-ENST00000539906NUP107chr1269135593+165813131131588491
ENST00000344911NTN4chr1296131644-ENST00000229179NUP107chr1269135593+1669850431125360
ENST00000344911NTN4chr1296131644-ENST00000378905NUP107chr1269135593+1347850431125360
ENST00000344911NTN4chr1296131644-ENST00000539906NUP107chr1269135593+1195850431125360
ENST00000553059NTN4chr1296131644-ENST00000229179NUP107chr1269135593+168386401139379
ENST00000553059NTN4chr1296131644-ENST00000378905NUP107chr1269135593+136186401139379
ENST00000553059NTN4chr1296131644-ENST00000539906NUP107chr1269135593+120986401139379

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000343702ENST00000229179NTN4chr1296131644-NUP107chr1269135593+0.0029909020.9970091
ENST00000343702ENST00000378905NTN4chr1296131644-NUP107chr1269135593+0.0070842830.99291575
ENST00000343702ENST00000539906NTN4chr1296131644-NUP107chr1269135593+0.0127526080.98724747
ENST00000344911ENST00000229179NTN4chr1296131644-NUP107chr1269135593+0.001815950.998184
ENST00000344911ENST00000378905NTN4chr1296131644-NUP107chr1269135593+0.003346970.996653
ENST00000344911ENST00000539906NTN4chr1296131644-NUP107chr1269135593+0.0074919230.9925081
ENST00000553059ENST00000229179NTN4chr1296131644-NUP107chr1269135593+0.0012279370.9987721
ENST00000553059ENST00000378905NTN4chr1296131644-NUP107chr1269135593+0.0025511610.99744886
ENST00000553059ENST00000539906NTN4chr1296131644-NUP107chr1269135593+0.0055939030.9944061

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Fusion Genomic Features for NTN4-NUP107


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NTN4chr1296131643-NUP107chr1269135592+9.92E-060.9999901
NTN4chr1296131643-NUP107chr1269135592+9.92E-060.9999901

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NTN4-NUP107


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:96131644/chr12:69135593)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NUP107

P57740

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:12552102, PubMed:15229283, PubMed:30179222). Required for the assembly of peripheral proteins into the NPC (PubMed:15229283, PubMed:12552102). May anchor NUP62 to the NPC (PubMed:15229283). Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:12552102, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:30179222}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNTN4chr12:96131644chr12:69135593ENST00000343702-31030_261288629.0DomainLaminin N-terminal
HgeneNTN4chr12:96131644chr12:69135593ENST00000553059-3930_261288606.0DomainLaminin N-terminal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNTN4chr12:96131644chr12:69135593ENST00000343702-310262_331288629.0DomainLaminin EGF-like 1
HgeneNTN4chr12:96131644chr12:69135593ENST00000343702-310332_394288629.0DomainLaminin EGF-like 2
HgeneNTN4chr12:96131644chr12:69135593ENST00000343702-310395_448288629.0DomainLaminin EGF-like 3
HgeneNTN4chr12:96131644chr12:69135593ENST00000343702-310506_627288629.0DomainNTR
HgeneNTN4chr12:96131644chr12:69135593ENST00000344911-411262_331251592.0DomainLaminin EGF-like 1
HgeneNTN4chr12:96131644chr12:69135593ENST00000344911-41130_261251592.0DomainLaminin N-terminal
HgeneNTN4chr12:96131644chr12:69135593ENST00000344911-411332_394251592.0DomainLaminin EGF-like 2
HgeneNTN4chr12:96131644chr12:69135593ENST00000344911-411395_448251592.0DomainLaminin EGF-like 3
HgeneNTN4chr12:96131644chr12:69135593ENST00000344911-411506_627251592.0DomainNTR
HgeneNTN4chr12:96131644chr12:69135593ENST00000538383-310262_331251592.0DomainLaminin EGF-like 1
HgeneNTN4chr12:96131644chr12:69135593ENST00000538383-31030_261251592.0DomainLaminin N-terminal
HgeneNTN4chr12:96131644chr12:69135593ENST00000538383-310332_394251592.0DomainLaminin EGF-like 2
HgeneNTN4chr12:96131644chr12:69135593ENST00000538383-310395_448251592.0DomainLaminin EGF-like 3
HgeneNTN4chr12:96131644chr12:69135593ENST00000538383-310506_627251592.0DomainNTR
HgeneNTN4chr12:96131644chr12:69135593ENST00000553059-39262_331288606.0DomainLaminin EGF-like 1
HgeneNTN4chr12:96131644chr12:69135593ENST00000553059-39332_394288606.0DomainLaminin EGF-like 2
HgeneNTN4chr12:96131644chr12:69135593ENST00000553059-39395_448288606.0DomainLaminin EGF-like 3
HgeneNTN4chr12:96131644chr12:69135593ENST00000553059-39506_627288606.0DomainNTR


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Fusion Gene Sequence for NTN4-NUP107


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>60681_60681_1_NTN4-NUP107_NTN4_chr12_96131644_ENST00000343702_NUP107_chr12_69135593_ENST00000229179_length(transcript)=2132nt_BP=1313nt
GGACGGGACGGAGCCGGGGCAGCCAGAAGAGGTGGGAAAAGCGGAGGAGGACGCCCAGGAGGAGGCGGCGGCGGCGGCCGGGAAGTGAAA
GGTCTCGCAAAGTTCAGCGGCGGCTGCGGGCGCCGAGCCCCGGGCTAGCGGCAGACGAGCCCGCAGGGCCGCTCCGCGGGGCAGCGCAGC
CAGGCCGGCTATGGTCCCGGGGCTCCCGCCGCCCCCCAGGTGCCCGGGACCCGCCAGGCCGGTGCGCGAGGGTCACCCCACCTCCCCGCG
CGGTCCCGGCCCCTGGCTCCCAGCTGCCGGCGACCGCTGACCGAGCCCGGCGCCCCAGGAGGAGGAAGAAACCAGGGCCCCGTTCCCTCC
CGAGGACGGCGGCGCTTCATCCCGCAGCCCAGAGGTCTCGGCTCCCTCCGGCACCCGCCCGGCCCGGCTGCTCCCGGCTCCTCCCGGCCA
TGGGGAGCTGCGCGCGGCTGCTGCTGCTCTGGGGCTGCACGGTGGTGGCCGCAGGACTGAGTGGAGTAGCTGGAGTGAGTTCCCGCTGTG
AAAAAGCCTGCAACCCTCGGATGGGAAATTTGGCTTTGGGGCGAAAACTCTGGGCAGACACCACCTGCGGTCAGAATGCTACCGAACTGT
ACTGCTTCTACAGTGAGAACACGGATCTGACTTGTCGGCAGCCCAAATGTGACAAGTGCAATGCTGCCTATCCTCACCTGGCTCACCTGC
CATCTGCCATGGCAGACTCATCCTTCCGGTTTCCTCGCACATGGTGGCAGTCTGCGGAGGATGTGCACAGAGAAAAGATCCAGTTAGACC
TGGAAGCTGAATTCTACTTCACTCACCTAATTGTGATGTTCAAGTCCCCCAGGCCGGCTGCCATGGTGCTGGACCGCTCCCAGGACTTTG
GGAAAACATGGAAGCCTTATAAGTACTTTGCGACTAACTGCTCCGCTACATTTGGCCTGGAAGATGATGTTGTCAAGAAGGGCGCTATTT
GTACTTCTAAATACTCCAGTCCTTTTCCATGCACTGGAGGAGAGGTTATTTTCAAAGCTTTGTCACCACCATACGATACAGAGAACCCTT
ACAGTGCCAAAGTTCAGGAGCAGCTGAAGATCACCAACCTTCGCGTGCAGCTGCTGAAACGACAGTCTTGTCCCTGTCAGAGAAATGACC
TGAACGAAGAGCCTCAACATTTTACACACTATGCAATCTATGATTTCATTGTCAAGGGCAGCTGCTTCTGCAATGGCCACGCTGATCAAT
GCATACCTGTTCATGGCTTCAGACCTGTCAAGGCCCCAGGAACATTCCACATGGATGCCAAAGAAGACCATGAAAGAACACATCAAATGG
TCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAGT
TAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAGT
CCTCTCTAATGCTCCTAGACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCATG
ATAAATGAAGTTTTTAATAAAATATACTTGTTATTAGTAATTTTTTCTTTTGCATTACCATGTAAAATTTAGACATTTGAATTTTGTACT
TTTCAGAATATTATCGTGACACTTTCAACATGTAGGGATATCAGCGTTTCTCTGTGTGCTTGTTAATAAAACTATATAAAAATTAAAATT
TTCTGTTTTTACAAATTCCAGGGTTGTCTCTTTTTCATGTAATAAGAAAATTAAATTTTCTGTTCTAGTTTTTTCTGTAATCATAAGCAT
TCTGATATTTTAAAATCATAAAGATGATGGAAAGTAGATTTATTTTTAAGCCAGGTACGTAATTTTTTATTTATCATAAAATTTAGTATT
TTTGAATATTAAAATTAAGAAGATGACTATAACAAGAATTTTTCTAACATAACATGCTATTATTATTTTAGTTATTTTGAAGACATTTCT

>60681_60681_1_NTN4-NUP107_NTN4_chr12_96131644_ENST00000343702_NUP107_chr12_69135593_ENST00000229179_length(amino acids)=491AA_BP=400
MRAPSPGLAADEPAGPLRGAAQPGRLWSRGSRRPPGARDPPGRCARVTPPPRAVPAPGSQLPATADRARRPRRRKKPGPRSLPRTAALHP
AAQRSRLPPAPARPGCSRLLPAMGSCARLLLLWGCTVVAAGLSGVAGVSSRCEKACNPRMGNLALGRKLWADTTCGQNATELYCFYSENT
DLTCRQPKCDKCNAAYPHLAHLPSAMADSSFRFPRTWWQSAEDVHREKIQLDLEAEFYFTHLIVMFKSPRPAAMVLDRSQDFGKTWKPYK
YFATNCSATFGLEDDVVKKGAICTSKYSSPFPCTGGEVIFKALSPPYDTENPYSAKVQEQLKITNLRVQLLKRQSCPCQRNDLNEEPQHF
THYAIYDFIVKGSCFCNGHADQCIPVHGFRPVKAPGTFHMDAKEDHERTHQMVLLRKLCLPMLCFLLHTILHSTGQYQECLQLADMVSSE

--------------------------------------------------------------
>60681_60681_2_NTN4-NUP107_NTN4_chr12_96131644_ENST00000343702_NUP107_chr12_69135593_ENST00000378905_length(transcript)=1810nt_BP=1313nt
GGACGGGACGGAGCCGGGGCAGCCAGAAGAGGTGGGAAAAGCGGAGGAGGACGCCCAGGAGGAGGCGGCGGCGGCGGCCGGGAAGTGAAA
GGTCTCGCAAAGTTCAGCGGCGGCTGCGGGCGCCGAGCCCCGGGCTAGCGGCAGACGAGCCCGCAGGGCCGCTCCGCGGGGCAGCGCAGC
CAGGCCGGCTATGGTCCCGGGGCTCCCGCCGCCCCCCAGGTGCCCGGGACCCGCCAGGCCGGTGCGCGAGGGTCACCCCACCTCCCCGCG
CGGTCCCGGCCCCTGGCTCCCAGCTGCCGGCGACCGCTGACCGAGCCCGGCGCCCCAGGAGGAGGAAGAAACCAGGGCCCCGTTCCCTCC
CGAGGACGGCGGCGCTTCATCCCGCAGCCCAGAGGTCTCGGCTCCCTCCGGCACCCGCCCGGCCCGGCTGCTCCCGGCTCCTCCCGGCCA
TGGGGAGCTGCGCGCGGCTGCTGCTGCTCTGGGGCTGCACGGTGGTGGCCGCAGGACTGAGTGGAGTAGCTGGAGTGAGTTCCCGCTGTG
AAAAAGCCTGCAACCCTCGGATGGGAAATTTGGCTTTGGGGCGAAAACTCTGGGCAGACACCACCTGCGGTCAGAATGCTACCGAACTGT
ACTGCTTCTACAGTGAGAACACGGATCTGACTTGTCGGCAGCCCAAATGTGACAAGTGCAATGCTGCCTATCCTCACCTGGCTCACCTGC
CATCTGCCATGGCAGACTCATCCTTCCGGTTTCCTCGCACATGGTGGCAGTCTGCGGAGGATGTGCACAGAGAAAAGATCCAGTTAGACC
TGGAAGCTGAATTCTACTTCACTCACCTAATTGTGATGTTCAAGTCCCCCAGGCCGGCTGCCATGGTGCTGGACCGCTCCCAGGACTTTG
GGAAAACATGGAAGCCTTATAAGTACTTTGCGACTAACTGCTCCGCTACATTTGGCCTGGAAGATGATGTTGTCAAGAAGGGCGCTATTT
GTACTTCTAAATACTCCAGTCCTTTTCCATGCACTGGAGGAGAGGTTATTTTCAAAGCTTTGTCACCACCATACGATACAGAGAACCCTT
ACAGTGCCAAAGTTCAGGAGCAGCTGAAGATCACCAACCTTCGCGTGCAGCTGCTGAAACGACAGTCTTGTCCCTGTCAGAGAAATGACC
TGAACGAAGAGCCTCAACATTTTACACACTATGCAATCTATGATTTCATTGTCAAGGGCAGCTGCTTCTGCAATGGCCACGCTGATCAAT
GCATACCTGTTCATGGCTTCAGACCTGTCAAGGCCCCAGGAACATTCCACATGGATGCCAAAGAAGACCATGAAAGAACACATCAAATGG
TCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAGT
TAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAGT
CCTCTCTAATGCTCCTAGACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCATG
ATAAATGAAGTTTTTAATAAAATATACTTGTTATTAGTAATTTTTTCTTTTGCATTACCATGTAAAATTTAGACATTTGAATTTTGTACT
TTTCAGAATATTATCGTGACACTTTCAACATGTAGGGATATCAGCGTTTCTCTGTGTGCTTGTTAATAAAACTATATAAAAATTAAAATT

>60681_60681_2_NTN4-NUP107_NTN4_chr12_96131644_ENST00000343702_NUP107_chr12_69135593_ENST00000378905_length(amino acids)=491AA_BP=400
MRAPSPGLAADEPAGPLRGAAQPGRLWSRGSRRPPGARDPPGRCARVTPPPRAVPAPGSQLPATADRARRPRRRKKPGPRSLPRTAALHP
AAQRSRLPPAPARPGCSRLLPAMGSCARLLLLWGCTVVAAGLSGVAGVSSRCEKACNPRMGNLALGRKLWADTTCGQNATELYCFYSENT
DLTCRQPKCDKCNAAYPHLAHLPSAMADSSFRFPRTWWQSAEDVHREKIQLDLEAEFYFTHLIVMFKSPRPAAMVLDRSQDFGKTWKPYK
YFATNCSATFGLEDDVVKKGAICTSKYSSPFPCTGGEVIFKALSPPYDTENPYSAKVQEQLKITNLRVQLLKRQSCPCQRNDLNEEPQHF
THYAIYDFIVKGSCFCNGHADQCIPVHGFRPVKAPGTFHMDAKEDHERTHQMVLLRKLCLPMLCFLLHTILHSTGQYQECLQLADMVSSE

--------------------------------------------------------------
>60681_60681_3_NTN4-NUP107_NTN4_chr12_96131644_ENST00000343702_NUP107_chr12_69135593_ENST00000539906_length(transcript)=1658nt_BP=1313nt
GGACGGGACGGAGCCGGGGCAGCCAGAAGAGGTGGGAAAAGCGGAGGAGGACGCCCAGGAGGAGGCGGCGGCGGCGGCCGGGAAGTGAAA
GGTCTCGCAAAGTTCAGCGGCGGCTGCGGGCGCCGAGCCCCGGGCTAGCGGCAGACGAGCCCGCAGGGCCGCTCCGCGGGGCAGCGCAGC
CAGGCCGGCTATGGTCCCGGGGCTCCCGCCGCCCCCCAGGTGCCCGGGACCCGCCAGGCCGGTGCGCGAGGGTCACCCCACCTCCCCGCG
CGGTCCCGGCCCCTGGCTCCCAGCTGCCGGCGACCGCTGACCGAGCCCGGCGCCCCAGGAGGAGGAAGAAACCAGGGCCCCGTTCCCTCC
CGAGGACGGCGGCGCTTCATCCCGCAGCCCAGAGGTCTCGGCTCCCTCCGGCACCCGCCCGGCCCGGCTGCTCCCGGCTCCTCCCGGCCA
TGGGGAGCTGCGCGCGGCTGCTGCTGCTCTGGGGCTGCACGGTGGTGGCCGCAGGACTGAGTGGAGTAGCTGGAGTGAGTTCCCGCTGTG
AAAAAGCCTGCAACCCTCGGATGGGAAATTTGGCTTTGGGGCGAAAACTCTGGGCAGACACCACCTGCGGTCAGAATGCTACCGAACTGT
ACTGCTTCTACAGTGAGAACACGGATCTGACTTGTCGGCAGCCCAAATGTGACAAGTGCAATGCTGCCTATCCTCACCTGGCTCACCTGC
CATCTGCCATGGCAGACTCATCCTTCCGGTTTCCTCGCACATGGTGGCAGTCTGCGGAGGATGTGCACAGAGAAAAGATCCAGTTAGACC
TGGAAGCTGAATTCTACTTCACTCACCTAATTGTGATGTTCAAGTCCCCCAGGCCGGCTGCCATGGTGCTGGACCGCTCCCAGGACTTTG
GGAAAACATGGAAGCCTTATAAGTACTTTGCGACTAACTGCTCCGCTACATTTGGCCTGGAAGATGATGTTGTCAAGAAGGGCGCTATTT
GTACTTCTAAATACTCCAGTCCTTTTCCATGCACTGGAGGAGAGGTTATTTTCAAAGCTTTGTCACCACCATACGATACAGAGAACCCTT
ACAGTGCCAAAGTTCAGGAGCAGCTGAAGATCACCAACCTTCGCGTGCAGCTGCTGAAACGACAGTCTTGTCCCTGTCAGAGAAATGACC
TGAACGAAGAGCCTCAACATTTTACACACTATGCAATCTATGATTTCATTGTCAAGGGCAGCTGCTTCTGCAATGGCCACGCTGATCAAT
GCATACCTGTTCATGGCTTCAGACCTGTCAAGGCCCCAGGAACATTCCACATGGATGCCAAAGAAGACCATGAAAGAACACATCAAATGG
TCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAGT
TAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAGT
CCTCTCTAATGCTCCTAGACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCATG

>60681_60681_3_NTN4-NUP107_NTN4_chr12_96131644_ENST00000343702_NUP107_chr12_69135593_ENST00000539906_length(amino acids)=491AA_BP=400
MRAPSPGLAADEPAGPLRGAAQPGRLWSRGSRRPPGARDPPGRCARVTPPPRAVPAPGSQLPATADRARRPRRRKKPGPRSLPRTAALHP
AAQRSRLPPAPARPGCSRLLPAMGSCARLLLLWGCTVVAAGLSGVAGVSSRCEKACNPRMGNLALGRKLWADTTCGQNATELYCFYSENT
DLTCRQPKCDKCNAAYPHLAHLPSAMADSSFRFPRTWWQSAEDVHREKIQLDLEAEFYFTHLIVMFKSPRPAAMVLDRSQDFGKTWKPYK
YFATNCSATFGLEDDVVKKGAICTSKYSSPFPCTGGEVIFKALSPPYDTENPYSAKVQEQLKITNLRVQLLKRQSCPCQRNDLNEEPQHF
THYAIYDFIVKGSCFCNGHADQCIPVHGFRPVKAPGTFHMDAKEDHERTHQMVLLRKLCLPMLCFLLHTILHSTGQYQECLQLADMVSSE

--------------------------------------------------------------
>60681_60681_4_NTN4-NUP107_NTN4_chr12_96131644_ENST00000344911_NUP107_chr12_69135593_ENST00000229179_length(transcript)=1669nt_BP=850nt
GGAGAAGGACGGGACGGAGCCGGGGCAGCCAGAAGAGGTGGGACTGAGTGGAGTAGCTGGAGTGAGTTCCCGCTGTGAAAAAGCCTGCAA
CCCTCGGATGGGAAATTTGGCTTTGGGGCGAAAACTCTGGGCAGACACCACCTGCGGTCAGAATGCTACCGAACTGTACTGCTTCTACAG
TGAGAACACGGATCTGACTTGTCGGCAGCCCAAATGTGACAAGTGCAATGCTGCCTATCCTCACCTGGCTCACCTGCCATCTGCCATGGC
AGACTCATCCTTCCGGTTTCCTCGCACATGGTGGCAGTCTGCGGAGGATGTGCACAGAGAAAAGATCCAGTTAGACCTGGAAGCTGAATT
CTACTTCACTCACCTAATTGTGATGTTCAAGTCCCCCAGGCCGGCTGCCATGGTGCTGGACCGCTCCCAGGACTTTGGGAAAACATGGAA
GCCTTATAAGTACTTTGCGACTAACTGCTCCGCTACATTTGGCCTGGAAGATGATGTTGTCAAGAAGGGCGCTATTTGTACTTCTAAATA
CTCCAGTCCTTTTCCATGCACTGGAGGAGAGGTTATTTTCAAAGCTTTGTCACCACCATACGATACAGAGAACCCTTACAGTGCCAAAGT
TCAGGAGCAGCTGAAGATCACCAACCTTCGCGTGCAGCTGCTGAAACGACAGTCTTGTCCCTGTCAGAGAAATGACCTGAACGAAGAGCC
TCAACATTTTACACACTATGCAATCTATGATTTCATTGTCAAGGGCAGCTGCTTCTGCAATGGCCACGCTGATCAATGCATACCTGTTCA
TGGCTTCAGACCTGTCAAGGCCCCAGGAACATTCCACATGGATGCCAAAGAAGACCATGAAAGAACACATCAAATGGTCTTACTGAGAAA
GCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAGTTAGCAGATATGGT
ATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAGTCCTCTCTAATGCT
CCTAGACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCATGATAAATGAAGTTT
TTAATAAAATATACTTGTTATTAGTAATTTTTTCTTTTGCATTACCATGTAAAATTTAGACATTTGAATTTTGTACTTTTCAGAATATTA
TCGTGACACTTTCAACATGTAGGGATATCAGCGTTTCTCTGTGTGCTTGTTAATAAAACTATATAAAAATTAAAATTTTCTGTTTTTACA
AATTCCAGGGTTGTCTCTTTTTCATGTAATAAGAAAATTAAATTTTCTGTTCTAGTTTTTTCTGTAATCATAAGCATTCTGATATTTTAA
AATCATAAAGATGATGGAAAGTAGATTTATTTTTAAGCCAGGTACGTAATTTTTTATTTATCATAAAATTTAGTATTTTTGAATATTAAA
ATTAAGAAGATGACTATAACAAGAATTTTTCTAACATAACATGCTATTATTATTTTAGTTATTTTGAAGACATTTCTAGTTTAACTTTCA

>60681_60681_4_NTN4-NUP107_NTN4_chr12_96131644_ENST00000344911_NUP107_chr12_69135593_ENST00000229179_length(amino acids)=360AA_BP=269
MSGVAGVSSRCEKACNPRMGNLALGRKLWADTTCGQNATELYCFYSENTDLTCRQPKCDKCNAAYPHLAHLPSAMADSSFRFPRTWWQSA
EDVHREKIQLDLEAEFYFTHLIVMFKSPRPAAMVLDRSQDFGKTWKPYKYFATNCSATFGLEDDVVKKGAICTSKYSSPFPCTGGEVIFK
ALSPPYDTENPYSAKVQEQLKITNLRVQLLKRQSCPCQRNDLNEEPQHFTHYAIYDFIVKGSCFCNGHADQCIPVHGFRPVKAPGTFHMD
AKEDHERTHQMVLLRKLCLPMLCFLLHTILHSTGQYQECLQLADMVSSERHKLYLVFSKEELRKLLQKLRESSLMLLDQGLDPLGYEIQL

--------------------------------------------------------------
>60681_60681_5_NTN4-NUP107_NTN4_chr12_96131644_ENST00000344911_NUP107_chr12_69135593_ENST00000378905_length(transcript)=1347nt_BP=850nt
GGAGAAGGACGGGACGGAGCCGGGGCAGCCAGAAGAGGTGGGACTGAGTGGAGTAGCTGGAGTGAGTTCCCGCTGTGAAAAAGCCTGCAA
CCCTCGGATGGGAAATTTGGCTTTGGGGCGAAAACTCTGGGCAGACACCACCTGCGGTCAGAATGCTACCGAACTGTACTGCTTCTACAG
TGAGAACACGGATCTGACTTGTCGGCAGCCCAAATGTGACAAGTGCAATGCTGCCTATCCTCACCTGGCTCACCTGCCATCTGCCATGGC
AGACTCATCCTTCCGGTTTCCTCGCACATGGTGGCAGTCTGCGGAGGATGTGCACAGAGAAAAGATCCAGTTAGACCTGGAAGCTGAATT
CTACTTCACTCACCTAATTGTGATGTTCAAGTCCCCCAGGCCGGCTGCCATGGTGCTGGACCGCTCCCAGGACTTTGGGAAAACATGGAA
GCCTTATAAGTACTTTGCGACTAACTGCTCCGCTACATTTGGCCTGGAAGATGATGTTGTCAAGAAGGGCGCTATTTGTACTTCTAAATA
CTCCAGTCCTTTTCCATGCACTGGAGGAGAGGTTATTTTCAAAGCTTTGTCACCACCATACGATACAGAGAACCCTTACAGTGCCAAAGT
TCAGGAGCAGCTGAAGATCACCAACCTTCGCGTGCAGCTGCTGAAACGACAGTCTTGTCCCTGTCAGAGAAATGACCTGAACGAAGAGCC
TCAACATTTTACACACTATGCAATCTATGATTTCATTGTCAAGGGCAGCTGCTTCTGCAATGGCCACGCTGATCAATGCATACCTGTTCA
TGGCTTCAGACCTGTCAAGGCCCCAGGAACATTCCACATGGATGCCAAAGAAGACCATGAAAGAACACATCAAATGGTCTTACTGAGAAA
GCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAGTTAGCAGATATGGT
ATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAGTCCTCTCTAATGCT
CCTAGACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCATGATAAATGAAGTTT
TTAATAAAATATACTTGTTATTAGTAATTTTTTCTTTTGCATTACCATGTAAAATTTAGACATTTGAATTTTGTACTTTTCAGAATATTA

>60681_60681_5_NTN4-NUP107_NTN4_chr12_96131644_ENST00000344911_NUP107_chr12_69135593_ENST00000378905_length(amino acids)=360AA_BP=269
MSGVAGVSSRCEKACNPRMGNLALGRKLWADTTCGQNATELYCFYSENTDLTCRQPKCDKCNAAYPHLAHLPSAMADSSFRFPRTWWQSA
EDVHREKIQLDLEAEFYFTHLIVMFKSPRPAAMVLDRSQDFGKTWKPYKYFATNCSATFGLEDDVVKKGAICTSKYSSPFPCTGGEVIFK
ALSPPYDTENPYSAKVQEQLKITNLRVQLLKRQSCPCQRNDLNEEPQHFTHYAIYDFIVKGSCFCNGHADQCIPVHGFRPVKAPGTFHMD
AKEDHERTHQMVLLRKLCLPMLCFLLHTILHSTGQYQECLQLADMVSSERHKLYLVFSKEELRKLLQKLRESSLMLLDQGLDPLGYEIQL

--------------------------------------------------------------
>60681_60681_6_NTN4-NUP107_NTN4_chr12_96131644_ENST00000344911_NUP107_chr12_69135593_ENST00000539906_length(transcript)=1195nt_BP=850nt
GGAGAAGGACGGGACGGAGCCGGGGCAGCCAGAAGAGGTGGGACTGAGTGGAGTAGCTGGAGTGAGTTCCCGCTGTGAAAAAGCCTGCAA
CCCTCGGATGGGAAATTTGGCTTTGGGGCGAAAACTCTGGGCAGACACCACCTGCGGTCAGAATGCTACCGAACTGTACTGCTTCTACAG
TGAGAACACGGATCTGACTTGTCGGCAGCCCAAATGTGACAAGTGCAATGCTGCCTATCCTCACCTGGCTCACCTGCCATCTGCCATGGC
AGACTCATCCTTCCGGTTTCCTCGCACATGGTGGCAGTCTGCGGAGGATGTGCACAGAGAAAAGATCCAGTTAGACCTGGAAGCTGAATT
CTACTTCACTCACCTAATTGTGATGTTCAAGTCCCCCAGGCCGGCTGCCATGGTGCTGGACCGCTCCCAGGACTTTGGGAAAACATGGAA
GCCTTATAAGTACTTTGCGACTAACTGCTCCGCTACATTTGGCCTGGAAGATGATGTTGTCAAGAAGGGCGCTATTTGTACTTCTAAATA
CTCCAGTCCTTTTCCATGCACTGGAGGAGAGGTTATTTTCAAAGCTTTGTCACCACCATACGATACAGAGAACCCTTACAGTGCCAAAGT
TCAGGAGCAGCTGAAGATCACCAACCTTCGCGTGCAGCTGCTGAAACGACAGTCTTGTCCCTGTCAGAGAAATGACCTGAACGAAGAGCC
TCAACATTTTACACACTATGCAATCTATGATTTCATTGTCAAGGGCAGCTGCTTCTGCAATGGCCACGCTGATCAATGCATACCTGTTCA
TGGCTTCAGACCTGTCAAGGCCCCAGGAACATTCCACATGGATGCCAAAGAAGACCATGAAAGAACACATCAAATGGTCTTACTGAGAAA
GCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAGTTAGCAGATATGGT
ATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAGTCCTCTCTAATGCT
CCTAGACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCATGATAAATGAAGTTT

>60681_60681_6_NTN4-NUP107_NTN4_chr12_96131644_ENST00000344911_NUP107_chr12_69135593_ENST00000539906_length(amino acids)=360AA_BP=269
MSGVAGVSSRCEKACNPRMGNLALGRKLWADTTCGQNATELYCFYSENTDLTCRQPKCDKCNAAYPHLAHLPSAMADSSFRFPRTWWQSA
EDVHREKIQLDLEAEFYFTHLIVMFKSPRPAAMVLDRSQDFGKTWKPYKYFATNCSATFGLEDDVVKKGAICTSKYSSPFPCTGGEVIFK
ALSPPYDTENPYSAKVQEQLKITNLRVQLLKRQSCPCQRNDLNEEPQHFTHYAIYDFIVKGSCFCNGHADQCIPVHGFRPVKAPGTFHMD
AKEDHERTHQMVLLRKLCLPMLCFLLHTILHSTGQYQECLQLADMVSSERHKLYLVFSKEELRKLLQKLRESSLMLLDQGLDPLGYEIQL

--------------------------------------------------------------
>60681_60681_7_NTN4-NUP107_NTN4_chr12_96131644_ENST00000553059_NUP107_chr12_69135593_ENST00000229179_length(transcript)=1683nt_BP=864nt
ATGGGGAGCTGCGCGCGGCTGCTGCTGCTCTGGGGCTGCACGGTGGTGGCCGCAGGACTGAGTGGAGTAGCTGGAGTGAGTTCCCGCTGT
GAAAAAGCCTGCAACCCTCGGATGGGAAATTTGGCTTTGGGGCGAAAACTCTGGGCAGACACCACCTGCGGTCAGAATGCTACCGAACTG
TACTGCTTCTACAGTGAGAACACGGATCTGACTTGTCGGCAGCCCAAATGTGACAAGTGCAATGCTGCCTATCCTCACCTGGCTCACCTG
CCATCTGCCATGGCAGACTCATCCTTCCGGTTTCCTCGCACATGGTGGCAGTCTGCGGAGGATGTGCACAGAGAAAAGATCCAGTTAGAC
CTGGAAGCTGAATTCTACTTCACTCACCTAATTGTGATGTTCAAGTCCCCCAGGCCGGCTGCCATGGTGCTGGACCGCTCCCAGGACTTT
GGGAAAACATGGAAGCCTTATAAGTACTTTGCGACTAACTGCTCCGCTACATTTGGCCTGGAAGATGATGTTGTCAAGAAGGGCGCTATT
TGTACTTCTAAATACTCCAGTCCTTTTCCATGCACTGGAGGAGAGGTTATTTTCAAAGCTTTGTCACCACCATACGATACAGAGAACCCT
TACAGTGCCAAAGTTCAGGAGCAGCTGAAGATCACCAACCTTCGCGTGCAGCTGCTGAAACGACAGTCTTGTCCCTGTCAGAGAAATGAC
CTGAACGAAGAGCCTCAACATTTTACACACTATGCAATCTATGATTTCATTGTCAAGGGCAGCTGCTTCTGCAATGGCCACGCTGATCAA
TGCATACCTGTTCATGGCTTCAGACCTGTCAAGGCCCCAGGAACATTCCACATGGATGCCAAAGAAGACCATGAAAGAACACATCAAATG
GTCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAG
TTAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAG
TCCTCTCTAATGCTCCTAGACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCAT
GATAAATGAAGTTTTTAATAAAATATACTTGTTATTAGTAATTTTTTCTTTTGCATTACCATGTAAAATTTAGACATTTGAATTTTGTAC
TTTTCAGAATATTATCGTGACACTTTCAACATGTAGGGATATCAGCGTTTCTCTGTGTGCTTGTTAATAAAACTATATAAAAATTAAAAT
TTTCTGTTTTTACAAATTCCAGGGTTGTCTCTTTTTCATGTAATAAGAAAATTAAATTTTCTGTTCTAGTTTTTTCTGTAATCATAAGCA
TTCTGATATTTTAAAATCATAAAGATGATGGAAAGTAGATTTATTTTTAAGCCAGGTACGTAATTTTTTATTTATCATAAAATTTAGTAT
TTTTGAATATTAAAATTAAGAAGATGACTATAACAAGAATTTTTCTAACATAACATGCTATTATTATTTTAGTTATTTTGAAGACATTTC

>60681_60681_7_NTN4-NUP107_NTN4_chr12_96131644_ENST00000553059_NUP107_chr12_69135593_ENST00000229179_length(amino acids)=379AA_BP=288
MGSCARLLLLWGCTVVAAGLSGVAGVSSRCEKACNPRMGNLALGRKLWADTTCGQNATELYCFYSENTDLTCRQPKCDKCNAAYPHLAHL
PSAMADSSFRFPRTWWQSAEDVHREKIQLDLEAEFYFTHLIVMFKSPRPAAMVLDRSQDFGKTWKPYKYFATNCSATFGLEDDVVKKGAI
CTSKYSSPFPCTGGEVIFKALSPPYDTENPYSAKVQEQLKITNLRVQLLKRQSCPCQRNDLNEEPQHFTHYAIYDFIVKGSCFCNGHADQ
CIPVHGFRPVKAPGTFHMDAKEDHERTHQMVLLRKLCLPMLCFLLHTILHSTGQYQECLQLADMVSSERHKLYLVFSKEELRKLLQKLRE

--------------------------------------------------------------
>60681_60681_8_NTN4-NUP107_NTN4_chr12_96131644_ENST00000553059_NUP107_chr12_69135593_ENST00000378905_length(transcript)=1361nt_BP=864nt
ATGGGGAGCTGCGCGCGGCTGCTGCTGCTCTGGGGCTGCACGGTGGTGGCCGCAGGACTGAGTGGAGTAGCTGGAGTGAGTTCCCGCTGT
GAAAAAGCCTGCAACCCTCGGATGGGAAATTTGGCTTTGGGGCGAAAACTCTGGGCAGACACCACCTGCGGTCAGAATGCTACCGAACTG
TACTGCTTCTACAGTGAGAACACGGATCTGACTTGTCGGCAGCCCAAATGTGACAAGTGCAATGCTGCCTATCCTCACCTGGCTCACCTG
CCATCTGCCATGGCAGACTCATCCTTCCGGTTTCCTCGCACATGGTGGCAGTCTGCGGAGGATGTGCACAGAGAAAAGATCCAGTTAGAC
CTGGAAGCTGAATTCTACTTCACTCACCTAATTGTGATGTTCAAGTCCCCCAGGCCGGCTGCCATGGTGCTGGACCGCTCCCAGGACTTT
GGGAAAACATGGAAGCCTTATAAGTACTTTGCGACTAACTGCTCCGCTACATTTGGCCTGGAAGATGATGTTGTCAAGAAGGGCGCTATT
TGTACTTCTAAATACTCCAGTCCTTTTCCATGCACTGGAGGAGAGGTTATTTTCAAAGCTTTGTCACCACCATACGATACAGAGAACCCT
TACAGTGCCAAAGTTCAGGAGCAGCTGAAGATCACCAACCTTCGCGTGCAGCTGCTGAAACGACAGTCTTGTCCCTGTCAGAGAAATGAC
CTGAACGAAGAGCCTCAACATTTTACACACTATGCAATCTATGATTTCATTGTCAAGGGCAGCTGCTTCTGCAATGGCCACGCTGATCAA
TGCATACCTGTTCATGGCTTCAGACCTGTCAAGGCCCCAGGAACATTCCACATGGATGCCAAAGAAGACCATGAAAGAACACATCAAATG
GTCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAG
TTAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAG
TCCTCTCTAATGCTCCTAGACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCAT
GATAAATGAAGTTTTTAATAAAATATACTTGTTATTAGTAATTTTTTCTTTTGCATTACCATGTAAAATTTAGACATTTGAATTTTGTAC
TTTTCAGAATATTATCGTGACACTTTCAACATGTAGGGATATCAGCGTTTCTCTGTGTGCTTGTTAATAAAACTATATAAAAATTAAAAT

>60681_60681_8_NTN4-NUP107_NTN4_chr12_96131644_ENST00000553059_NUP107_chr12_69135593_ENST00000378905_length(amino acids)=379AA_BP=288
MGSCARLLLLWGCTVVAAGLSGVAGVSSRCEKACNPRMGNLALGRKLWADTTCGQNATELYCFYSENTDLTCRQPKCDKCNAAYPHLAHL
PSAMADSSFRFPRTWWQSAEDVHREKIQLDLEAEFYFTHLIVMFKSPRPAAMVLDRSQDFGKTWKPYKYFATNCSATFGLEDDVVKKGAI
CTSKYSSPFPCTGGEVIFKALSPPYDTENPYSAKVQEQLKITNLRVQLLKRQSCPCQRNDLNEEPQHFTHYAIYDFIVKGSCFCNGHADQ
CIPVHGFRPVKAPGTFHMDAKEDHERTHQMVLLRKLCLPMLCFLLHTILHSTGQYQECLQLADMVSSERHKLYLVFSKEELRKLLQKLRE

--------------------------------------------------------------
>60681_60681_9_NTN4-NUP107_NTN4_chr12_96131644_ENST00000553059_NUP107_chr12_69135593_ENST00000539906_length(transcript)=1209nt_BP=864nt
ATGGGGAGCTGCGCGCGGCTGCTGCTGCTCTGGGGCTGCACGGTGGTGGCCGCAGGACTGAGTGGAGTAGCTGGAGTGAGTTCCCGCTGT
GAAAAAGCCTGCAACCCTCGGATGGGAAATTTGGCTTTGGGGCGAAAACTCTGGGCAGACACCACCTGCGGTCAGAATGCTACCGAACTG
TACTGCTTCTACAGTGAGAACACGGATCTGACTTGTCGGCAGCCCAAATGTGACAAGTGCAATGCTGCCTATCCTCACCTGGCTCACCTG
CCATCTGCCATGGCAGACTCATCCTTCCGGTTTCCTCGCACATGGTGGCAGTCTGCGGAGGATGTGCACAGAGAAAAGATCCAGTTAGAC
CTGGAAGCTGAATTCTACTTCACTCACCTAATTGTGATGTTCAAGTCCCCCAGGCCGGCTGCCATGGTGCTGGACCGCTCCCAGGACTTT
GGGAAAACATGGAAGCCTTATAAGTACTTTGCGACTAACTGCTCCGCTACATTTGGCCTGGAAGATGATGTTGTCAAGAAGGGCGCTATT
TGTACTTCTAAATACTCCAGTCCTTTTCCATGCACTGGAGGAGAGGTTATTTTCAAAGCTTTGTCACCACCATACGATACAGAGAACCCT
TACAGTGCCAAAGTTCAGGAGCAGCTGAAGATCACCAACCTTCGCGTGCAGCTGCTGAAACGACAGTCTTGTCCCTGTCAGAGAAATGAC
CTGAACGAAGAGCCTCAACATTTTACACACTATGCAATCTATGATTTCATTGTCAAGGGCAGCTGCTTCTGCAATGGCCACGCTGATCAA
TGCATACCTGTTCATGGCTTCAGACCTGTCAAGGCCCCAGGAACATTCCACATGGATGCCAAAGAAGACCATGAAAGAACACATCAAATG
GTCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAG
TTAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAG
TCCTCTCTAATGCTCCTAGACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCAT

>60681_60681_9_NTN4-NUP107_NTN4_chr12_96131644_ENST00000553059_NUP107_chr12_69135593_ENST00000539906_length(amino acids)=379AA_BP=288
MGSCARLLLLWGCTVVAAGLSGVAGVSSRCEKACNPRMGNLALGRKLWADTTCGQNATELYCFYSENTDLTCRQPKCDKCNAAYPHLAHL
PSAMADSSFRFPRTWWQSAEDVHREKIQLDLEAEFYFTHLIVMFKSPRPAAMVLDRSQDFGKTWKPYKYFATNCSATFGLEDDVVKKGAI
CTSKYSSPFPCTGGEVIFKALSPPYDTENPYSAKVQEQLKITNLRVQLLKRQSCPCQRNDLNEEPQHFTHYAIYDFIVKGSCFCNGHADQ
CIPVHGFRPVKAPGTFHMDAKEDHERTHQMVLLRKLCLPMLCFLLHTILHSTGQYQECLQLADMVSSERHKLYLVFSKEELRKLLQKLRE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NTN4-NUP107


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NTN4-NUP107


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NTN4-NUP107


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource