Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ARHGAP32-EPB41L2 (FusionGDB2 ID:6071)

Fusion Gene Summary for ARHGAP32-EPB41L2

Fusion gene summary

Fusion gene information	Fusion gene name: ARHGAP32-EPB41L2
	Fusion gene ID: 6071
		Hgene	Tgene
	Gene symbol	ARHGAP32	EPB41L2
	Gene ID	9743	2037
	Gene name	Rho GTPase activating protein 32	erythrocyte membrane protein band 4.1 like 2
	Synonyms	GC-GAP\|GRIT\|PX-RICS\|RICS\|p200RhoGAP\|p250GAP	4.1-G\|4.1G
	Cytomap	11q24.3	6q23.1-q23.2
	Type of gene	protein-coding	protein-coding
	Description	rho GTPase-activating protein 32GAB-associated CDC42GAB-associated Cdc42/Rac GTPase-activating proteinGTPase regulator interacting with TrkAGTPase-activating protein for Cdc42 and Rac1RhoGAP involved in the -catenin-N-cadherin and NMDA receptor signa	band 4.1-like protein 2erythrocyte membrane protein band 4.1 like-protein 2generally expressed protein 4.1
	Modification date	20200327	20200313
	UniProtAcc	A7KAX9	O43491
	Ensembl transtripts involved in fusion gene	ENST00000310343, ENST00000392657, ENST00000524655, ENST00000527272,	ENST00000337057, ENST00000368128, ENST00000392427, ENST00000445890, ENST00000524581, ENST00000525193, ENST00000525271, ENST00000527411, ENST00000527659, ENST00000528282, ENST00000529208, ENST00000530148, ENST00000530481, ENST00000530757, ENST00000531410,
Fusion gene scores	* DoF score	10 X 9 X 5=450	10 X 9 X 8=720
	# samples	11	10
	** MAII score	log2(11/450*10)=-2.03242147769238 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/720*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ARHGAP32 [Title/Abstract] AND EPB41L2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ARHGAP32(128835494)-EPB41L2(131182325), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ARHGAP32 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EPB41L2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	DA235187	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-

Top

Fusion Gene ORF analysis for ARHGAP32-EPB41L2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000310343	ENST00000337057	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000310343	ENST00000368128	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000310343	ENST00000392427	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000310343	ENST00000445890	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000310343	ENST00000524581	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000310343	ENST00000525193	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000310343	ENST00000525271	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000310343	ENST00000527411	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000310343	ENST00000527659	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000310343	ENST00000528282	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000310343	ENST00000529208	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000310343	ENST00000530148	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000310343	ENST00000530481	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000310343	ENST00000530757	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000310343	ENST00000531410	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000392657	ENST00000337057	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000392657	ENST00000368128	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000392657	ENST00000392427	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000392657	ENST00000445890	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000392657	ENST00000524581	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000392657	ENST00000525193	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000392657	ENST00000525271	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000392657	ENST00000527411	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000392657	ENST00000527659	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000392657	ENST00000528282	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000392657	ENST00000529208	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000392657	ENST00000530148	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000392657	ENST00000530481	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000392657	ENST00000530757	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000392657	ENST00000531410	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000524655	ENST00000337057	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000524655	ENST00000368128	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000524655	ENST00000392427	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000524655	ENST00000445890	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000524655	ENST00000524581	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000524655	ENST00000525193	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000524655	ENST00000525271	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000524655	ENST00000527411	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000524655	ENST00000527659	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000524655	ENST00000528282	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000524655	ENST00000529208	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000524655	ENST00000530148	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000524655	ENST00000530481	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000524655	ENST00000530757	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000524655	ENST00000531410	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000527272	ENST00000337057	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000527272	ENST00000368128	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000527272	ENST00000392427	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000527272	ENST00000445890	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000527272	ENST00000524581	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000527272	ENST00000525193	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000527272	ENST00000525271	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000527272	ENST00000527411	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000527272	ENST00000527659	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000527272	ENST00000528282	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000527272	ENST00000529208	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000527272	ENST00000530148	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000527272	ENST00000530481	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000527272	ENST00000530757	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-
intron-intron	ENST00000527272	ENST00000531410	ARHGAP32	chr11	128835494	-	EPB41L2	chr6	131182325	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for ARHGAP32-EPB41L2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ARHGAP32-EPB41L2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:128835494/:131182325)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ARHGAP32 A7KAX9	EPB41L2 O43491
FUNCTION: GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269\|PubMed:12446789, ECO:0000269\|PubMed:12454018, ECO:0000269\|PubMed:12531901, ECO:0000269\|PubMed:12788081, ECO:0000269\|PubMed:12819203, ECO:0000269\|PubMed:12857875, ECO:0000269\|PubMed:17663722}.	FUNCTION: Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269\|PubMed:23870127}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for ARHGAP32-EPB41L2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for ARHGAP32-EPB41L2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ARHGAP32-EPB41L2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ARHGAP32-EPB41L2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source