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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NTRK3-RBPMS (FusionGDB2 ID:60714)

Fusion Gene Summary for NTRK3-RBPMS

Fusion gene summary

Fusion gene information	Fusion gene name: NTRK3-RBPMS
	Fusion gene ID: 60714
		Hgene	Tgene
	Gene symbol	NTRK3	RBPMS
	Gene ID	4916	11030
	Gene name	neurotrophic receptor tyrosine kinase 3	RNA binding protein, mRNA processing factor
	Synonyms	GP145-TrkC\|TRKC\|gp145(trkC)	HERMES
	Cytomap	15q25.3	8p12
	Type of gene	protein-coding	protein-coding
	Description	NT-3 growth factor receptorETS related protein-neurotrophic receptor tyrosine kinase fusion proteinETV6-NTRK3 fusionneurotrophic tyrosine kinase, receptor, type 3tyrosine kinase receptor C	RNA-binding protein with multiple splicingRNA binding protein with multiple splicingheart and RRM expressed sequence
	Modification date	20200313	20200327
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000317501, ENST00000355254, ENST00000357724, ENST00000360948, ENST00000394480, ENST00000540489, ENST00000542733, ENST00000557856, ENST00000558676, ENST00000558306,	ENST00000287771, ENST00000320203, ENST00000339877, ENST00000397323, ENST00000517860, ENST00000519647, ENST00000520161, ENST00000520191, ENST00000520916, ENST00000538486,
Fusion gene scores	* DoF score	12 X 15 X 5=900	17 X 16 X 8=2176
	# samples	17	20
	** MAII score	log2(17/900*10)=-2.40439025507934 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(20/2176*10)=-3.44360665147561 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NTRK3 [Title/Abstract] AND RBPMS [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NTRK3(88669502)-RBPMS(30402011), # samples:3 RBPMS(30361953)-NTRK3(88576276), # samples:4
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NTRK3	GO:0000187	activation of MAPK activity	23027130
Hgene	NTRK3	GO:0001933	negative regulation of protein phosphorylation	23027130
Hgene	NTRK3	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	23027130
Hgene	NTRK3	GO:0008284	positive regulation of cell proliferation	23027130
Hgene	NTRK3	GO:0010628	positive regulation of gene expression	23027130
Hgene	NTRK3	GO:0030335	positive regulation of cell migration	23027130
Hgene	NTRK3	GO:0032148	activation of protein kinase B activity	23027130
Hgene	NTRK3	GO:0033138	positive regulation of peptidyl-serine phosphorylation	23027130
Hgene	NTRK3	GO:0050927	positive regulation of positive chemotaxis	23027130
Hgene	NTRK3	GO:0090630	activation of GTPase activity	23027130
Hgene	NTRK3	GO:2000251	positive regulation of actin cytoskeleton reorganization	23027130
Tgene	RBPMS	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	17099224
Tgene	RBPMS	GO:0060391	positive regulation of SMAD protein signal transduction	17099224

Fusion gene breakpoints across NTRK3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RBPMS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	THCA	TCGA-ET-A39L-01A	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
ChimerDB4	THCA	TCGA-ET-A39L	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+

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Fusion Gene ORF analysis for NTRK3-RBPMS

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000317501	ENST00000287771	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000317501	ENST00000287771	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000317501	ENST00000320203	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000317501	ENST00000320203	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000317501	ENST00000339877	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000317501	ENST00000339877	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000317501	ENST00000397323	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000317501	ENST00000397323	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000317501	ENST00000517860	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000317501	ENST00000517860	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000317501	ENST00000519647	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000317501	ENST00000519647	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000317501	ENST00000520161	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000317501	ENST00000520161	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000317501	ENST00000520191	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000317501	ENST00000520191	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000317501	ENST00000520916	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000317501	ENST00000520916	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000317501	ENST00000538486	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000317501	ENST00000538486	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000355254	ENST00000287771	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000355254	ENST00000287771	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000355254	ENST00000320203	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000355254	ENST00000320203	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000355254	ENST00000339877	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000355254	ENST00000339877	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000355254	ENST00000397323	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000355254	ENST00000397323	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000355254	ENST00000517860	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000355254	ENST00000517860	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000355254	ENST00000519647	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000355254	ENST00000519647	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000355254	ENST00000520161	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000355254	ENST00000520161	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000355254	ENST00000520191	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000355254	ENST00000520191	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000355254	ENST00000520916	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000355254	ENST00000520916	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000355254	ENST00000538486	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000355254	ENST00000538486	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000357724	ENST00000287771	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000357724	ENST00000287771	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000357724	ENST00000320203	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000357724	ENST00000320203	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000357724	ENST00000339877	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000357724	ENST00000339877	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000357724	ENST00000397323	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000357724	ENST00000397323	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000357724	ENST00000517860	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000357724	ENST00000517860	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000357724	ENST00000519647	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000357724	ENST00000519647	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000357724	ENST00000520161	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000357724	ENST00000520161	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000357724	ENST00000520191	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000357724	ENST00000520191	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000357724	ENST00000520916	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000357724	ENST00000520916	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000357724	ENST00000538486	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000357724	ENST00000538486	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000360948	ENST00000287771	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000360948	ENST00000287771	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000360948	ENST00000320203	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000360948	ENST00000320203	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000360948	ENST00000339877	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000360948	ENST00000339877	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000360948	ENST00000397323	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000360948	ENST00000397323	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000360948	ENST00000517860	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000360948	ENST00000517860	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000360948	ENST00000519647	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000360948	ENST00000519647	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000360948	ENST00000520161	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000360948	ENST00000520161	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000360948	ENST00000520191	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000360948	ENST00000520191	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000360948	ENST00000520916	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000360948	ENST00000520916	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000360948	ENST00000538486	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000360948	ENST00000538486	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000394480	ENST00000287771	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000394480	ENST00000287771	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000394480	ENST00000320203	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000394480	ENST00000320203	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000394480	ENST00000339877	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000394480	ENST00000339877	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000394480	ENST00000397323	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000394480	ENST00000397323	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000394480	ENST00000517860	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000394480	ENST00000517860	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000394480	ENST00000519647	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000394480	ENST00000519647	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000394480	ENST00000520161	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000394480	ENST00000520161	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000394480	ENST00000520191	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000394480	ENST00000520191	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000394480	ENST00000520916	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000394480	ENST00000520916	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000394480	ENST00000538486	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000394480	ENST00000538486	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000540489	ENST00000287771	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000540489	ENST00000287771	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000540489	ENST00000320203	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000540489	ENST00000320203	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000540489	ENST00000339877	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000540489	ENST00000339877	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000540489	ENST00000397323	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000540489	ENST00000397323	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000540489	ENST00000517860	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000540489	ENST00000517860	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000540489	ENST00000519647	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000540489	ENST00000519647	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000540489	ENST00000520161	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000540489	ENST00000520161	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000540489	ENST00000520191	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000540489	ENST00000520191	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000540489	ENST00000520916	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000540489	ENST00000520916	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000540489	ENST00000538486	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000540489	ENST00000538486	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000542733	ENST00000287771	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000542733	ENST00000287771	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000542733	ENST00000320203	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000542733	ENST00000320203	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000542733	ENST00000339877	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000542733	ENST00000339877	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000542733	ENST00000397323	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000542733	ENST00000397323	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000542733	ENST00000517860	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000542733	ENST00000517860	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000542733	ENST00000519647	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000542733	ENST00000519647	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000542733	ENST00000520161	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000542733	ENST00000520161	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000542733	ENST00000520191	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000542733	ENST00000520191	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000542733	ENST00000520916	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000542733	ENST00000520916	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000542733	ENST00000538486	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000542733	ENST00000538486	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000557856	ENST00000287771	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000557856	ENST00000287771	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000557856	ENST00000320203	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000557856	ENST00000320203	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000557856	ENST00000339877	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000557856	ENST00000339877	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000557856	ENST00000397323	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000557856	ENST00000397323	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000557856	ENST00000517860	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000557856	ENST00000517860	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000557856	ENST00000519647	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000557856	ENST00000519647	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000557856	ENST00000520161	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000557856	ENST00000520161	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000557856	ENST00000520191	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000557856	ENST00000520191	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000557856	ENST00000520916	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000557856	ENST00000520916	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000557856	ENST00000538486	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000557856	ENST00000538486	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000558676	ENST00000287771	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000558676	ENST00000287771	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000558676	ENST00000320203	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000558676	ENST00000320203	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000558676	ENST00000339877	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000558676	ENST00000339877	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000558676	ENST00000397323	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000558676	ENST00000397323	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000558676	ENST00000517860	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000558676	ENST00000517860	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000558676	ENST00000519647	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000558676	ENST00000519647	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000558676	ENST00000520161	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000558676	ENST00000520161	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000558676	ENST00000520191	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000558676	ENST00000520191	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000558676	ENST00000520916	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000558676	ENST00000520916	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
5CDS-intron	ENST00000558676	ENST00000538486	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
5CDS-intron	ENST00000558676	ENST00000538486	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
intron-intron	ENST00000558306	ENST00000287771	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
intron-intron	ENST00000558306	ENST00000287771	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
intron-intron	ENST00000558306	ENST00000320203	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
intron-intron	ENST00000558306	ENST00000320203	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
intron-intron	ENST00000558306	ENST00000339877	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
intron-intron	ENST00000558306	ENST00000339877	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
intron-intron	ENST00000558306	ENST00000397323	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
intron-intron	ENST00000558306	ENST00000397323	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
intron-intron	ENST00000558306	ENST00000517860	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
intron-intron	ENST00000558306	ENST00000517860	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
intron-intron	ENST00000558306	ENST00000519647	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
intron-intron	ENST00000558306	ENST00000519647	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
intron-intron	ENST00000558306	ENST00000520161	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
intron-intron	ENST00000558306	ENST00000520161	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
intron-intron	ENST00000558306	ENST00000520191	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
intron-intron	ENST00000558306	ENST00000520191	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
intron-intron	ENST00000558306	ENST00000520916	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
intron-intron	ENST00000558306	ENST00000520916	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+
intron-intron	ENST00000558306	ENST00000538486	NTRK3	chr15	88669502	-	RBPMS	chr8	30402011	+
intron-intron	ENST00000558306	ENST00000538486	NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for NTRK3-RBPMS

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+	0.00010376	0.9998963
NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+	0.00010376	0.9998963
NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+	0.00010376	0.9998963
NTRK3	chr15	88669501	-	RBPMS	chr8	30402010	+	0.00010376	0.9998963

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NTRK3-RBPMS

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:88669502/:30402011)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for NTRK3-RBPMS

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NTRK3-RBPMS

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for NTRK3-RBPMS

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for NTRK3-RBPMS

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source