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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:NUCB1-APOE (FusionGDB2 ID:60752)

Fusion Gene Summary for NUCB1-APOE

Fusion gene summary

Fusion gene information	Fusion gene name: NUCB1-APOE
	Fusion gene ID: 60752
		Hgene	Tgene
	Gene symbol	NUCB1	APOE
	Gene ID	4924	348
	Gene name	nucleobindin 1	apolipoprotein E
	Synonyms	CALNUC\|NUC	AD2\|APO-E\|ApoE4\|LDLCQ5\|LPG
	Cytomap	19q13.33	19q13.32
	Type of gene	protein-coding	protein-coding
	Description	nucleobindin-1	apolipoprotein Eapolipoprotein E3
	Modification date	20200313	20200329
	UniProtAcc	.	P02649
	Ensembl transtripts involved in fusion gene	ENST00000263273, ENST00000405315, ENST00000407032, ENST00000485798,	ENST00000252486,
Fusion gene scores	* DoF score	9 X 11 X 6=594	5 X 5 X 5=125
	# samples	14	5
	** MAII score	log2(14/594*10)=-2.0850361038558 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/125*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NUCB1 [Title/Abstract] AND APOE [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NUCB1(49409142)-APOE(45411017), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	APOE	GO:0001937	negative regulation of endothelial cell proliferation	9685360
Tgene	APOE	GO:0006641	triglyceride metabolic process	9649566
Tgene	APOE	GO:0006898	receptor-mediated endocytosis	1917954
Tgene	APOE	GO:0007186	G protein-coupled receptor signaling pathway	16443932
Tgene	APOE	GO:0007263	nitric oxide mediated signal transduction	8995232
Tgene	APOE	GO:0008203	cholesterol metabolic process	9649566
Tgene	APOE	GO:0010544	negative regulation of platelet activation	8995232
Tgene	APOE	GO:0010873	positive regulation of cholesterol esterification	15654758
Tgene	APOE	GO:0010875	positive regulation of cholesterol efflux	12042316\|14754908
Tgene	APOE	GO:0010976	positive regulation of neuron projection development	7592957\|23845000
Tgene	APOE	GO:0010977	negative regulation of neuron projection development	7592957
Tgene	APOE	GO:0015909	long-chain fatty acid transport	24345162
Tgene	APOE	GO:0017038	protein import	24446231
Tgene	APOE	GO:0019934	cGMP-mediated signaling	8995232
Tgene	APOE	GO:0030195	negative regulation of blood coagulation	8995232
Tgene	APOE	GO:0031175	neuron projection development	8939961
Tgene	APOE	GO:0032489	regulation of Cdc42 protein signal transduction	16443932
Tgene	APOE	GO:0032805	positive regulation of low-density lipoprotein particle receptor catabolic process	15950758
Tgene	APOE	GO:0033344	cholesterol efflux	11162594\|16443932\|23620513
Tgene	APOE	GO:0033700	phospholipid efflux	11162594
Tgene	APOE	GO:0034372	very-low-density lipoprotein particle remodeling	15654758
Tgene	APOE	GO:0034380	high-density lipoprotein particle assembly	14754908\|17305370
Tgene	APOE	GO:0034382	chylomicron remnant clearance	1911868
Tgene	APOE	GO:0034384	high-density lipoprotein particle clearance	210175
Tgene	APOE	GO:0034447	very-low-density lipoprotein particle clearance	1917954\|2762297
Tgene	APOE	GO:0042158	lipoprotein biosynthetic process	23620513
Tgene	APOE	GO:0042632	cholesterol homeostasis	9649566
Tgene	APOE	GO:0042982	amyloid precursor protein metabolic process	21593558
Tgene	APOE	GO:0043254	regulation of protein complex assembly	25207746
Tgene	APOE	GO:0043407	negative regulation of MAP kinase activity	9685360
Tgene	APOE	GO:0043537	negative regulation of blood vessel endothelial cell migration	9685360
Tgene	APOE	GO:0043691	reverse cholesterol transport	8127890
Tgene	APOE	GO:0045541	negative regulation of cholesterol biosynthetic process	1917954
Tgene	APOE	GO:0045807	positive regulation of endocytosis	7683668\|8300609
Tgene	APOE	GO:0046889	positive regulation of lipid biosynthetic process	12042316
Tgene	APOE	GO:0051000	positive regulation of nitric-oxide synthase activity	8995232
Tgene	APOE	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	15950758
Tgene	APOE	GO:0055089	fatty acid homeostasis	24345162
Tgene	APOE	GO:0060999	positive regulation of dendritic spine development	24328732
Tgene	APOE	GO:0071831	intermediate-density lipoprotein particle clearance	1917954
Tgene	APOE	GO:0090090	negative regulation of canonical Wnt signaling pathway	16805831
Tgene	APOE	GO:0097113	AMPA glutamate receptor clustering	24328732
Tgene	APOE	GO:0097114	NMDA glutamate receptor clustering	24328732
Tgene	APOE	GO:1900221	regulation of amyloid-beta clearance	24446231
Tgene	APOE	GO:1900272	negative regulation of long-term synaptic potentiation	16273551
Tgene	APOE	GO:1902430	negative regulation of amyloid-beta formation	24154541
Tgene	APOE	GO:1902952	positive regulation of dendritic spine maintenance	24328732
Tgene	APOE	GO:1902991	regulation of amyloid precursor protein catabolic process	28164773
Tgene	APOE	GO:1902995	positive regulation of phospholipid efflux	12042316
Tgene	APOE	GO:1903002	positive regulation of lipid transport across blood brain barrier	24345162
Tgene	APOE	GO:1905855	positive regulation of heparan sulfate binding	7683668
Tgene	APOE	GO:1905860	positive regulation of heparan sulfate proteoglycan binding	8300609
Tgene	APOE	GO:1905890	regulation of cellular response to very-low-density lipoprotein particle stimulus	7592957
Tgene	APOE	GO:1905906	regulation of amyloid fibril formation	25207746

Fusion gene breakpoints across NUCB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across APOE (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-UB-A7MF-01A	NUCB1	chr19	49409142	+	APOE	chr19	45411017	+

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Fusion Gene ORF analysis for NUCB1-APOE

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000263273	ENST00000252486	NUCB1	chr19	49409142	+	APOE	chr19	45411017	+
In-frame	ENST00000405315	ENST00000252486	NUCB1	chr19	49409142	+	APOE	chr19	45411017	+
In-frame	ENST00000407032	ENST00000252486	NUCB1	chr19	49409142	+	APOE	chr19	45411017	+
intron-3CDS	ENST00000485798	ENST00000252486	NUCB1	chr19	49409142	+	APOE	chr19	45411017	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000405315

NUCB1

chr19

49409142

ENST00000252486

APOE

chr19

45411017

1764

710

334

1620

428

ENST00000407032

NUCB1

chr19

49409142

ENST00000252486

APOE

chr19

45411017

1494

440

1350

428

ENST00000263273

NUCB1

chr19

49409142

ENST00000252486

APOE

chr19

45411017

1443

389

1299

428

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000405315	ENST00000252486	NUCB1	chr19	49409142	+	APOE	chr19	45411017	+	0.009994756	0.9900052
ENST00000407032	ENST00000252486	NUCB1	chr19	49409142	+	APOE	chr19	45411017	+	0.010230253	0.9897697
ENST00000263273	ENST00000252486	NUCB1	chr19	49409142	+	APOE	chr19	45411017	+	0.010859282	0.98914075

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Fusion Genomic Features for NUCB1-APOE

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
NUCB1	chr19	49409142	+	APOE	chr19	45411016	+	1.48E-10	1
NUCB1	chr19	49409142	+	APOE	chr19	45411016	+	1.48E-10	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NUCB1-APOE

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:49409142/chr19:45411017)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	APOE P02649
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids (PubMed:6860692, PubMed:1911868, PubMed:14754908). APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance (PubMed:6860692, PubMed:2762297, PubMed:1911868, PubMed:1917954, PubMed:9395455, PubMed:14754908, PubMed:23620513). Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma (PubMed:6860692, PubMed:2762297, PubMed:9395455). As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL) (PubMed:6860692, PubMed:1911868). It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles (PubMed:2762297, PubMed:1917954, PubMed:7768901, PubMed:8939961, PubMed:12950167, PubMed:20030366, PubMed:2063194, PubMed:8756331, PubMed:20303980, PubMed:1530612, PubMed:7635945). Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells (PubMed:9395455, PubMed:9488694, PubMed:23676495, PubMed:7635945). A main function of APOE is to mediate lipoprotein clearance through the uptake of chylomicrons, VLDLs, and HDLs by hepatocytes (PubMed:1911868, PubMed:1917954, PubMed:9395455, PubMed:23676495, PubMed:29516132). APOE is also involved in the biosynthesis by the liver of VLDLs as well as their uptake by peripheral tissues ensuring the delivery of triglycerides and energy storage in muscle, heart and adipose tissues (PubMed:2762297, PubMed:29516132). By participating in the lipoprotein-mediated distribution of lipids among tissues, APOE plays a critical role in plasma and tissues lipid homeostasis (PubMed:2762297, PubMed:1917954, PubMed:29516132). APOE is also involved in two steps of reverse cholesterol transport, the HDLs-mediated transport of cholesterol from peripheral tissues to the liver, and thereby plays an important role in cholesterol homeostasis (PubMed:9395455, PubMed:14754908, PubMed:23620513). First, it is functionally associated with ABCA1 in the biogenesis of HDLs in tissues (PubMed:14754908, PubMed:23620513). Second, it is enriched in circulating HDLs and mediates their uptake by hepatocytes (PubMed:9395455). APOE also plays an important role in lipid transport in the central nervous system, regulating neuron survival and sprouting (PubMed:8939961, PubMed:25173806). APOE in also involved in innate and adaptive immune responses, controlling for instance the survival of myeloid-derived suppressor cells (By similarity). APOE, may also play a role in transcription regulation through a receptor-dependent and cholesterol-independent mechanism, that activates MAP3K12 and a non-canonical MAPK signal transduction pathway that results in enhanced AP-1-mediated transcription of APP (PubMed:28111074). {ECO:0000250\|UniProtKB:P08226, ECO:0000269\|PubMed:12950167, ECO:0000269\|PubMed:14754908, ECO:0000269\|PubMed:1530612, ECO:0000269\|PubMed:1911868, ECO:0000269\|PubMed:1917954, ECO:0000269\|PubMed:20030366, ECO:0000269\|PubMed:20303980, ECO:0000269\|PubMed:2063194, ECO:0000269\|PubMed:23620513, ECO:0000269\|PubMed:23676495, ECO:0000269\|PubMed:2762297, ECO:0000269\|PubMed:28111074, ECO:0000269\|PubMed:6860692, ECO:0000269\|PubMed:7635945, ECO:0000269\|PubMed:7768901, ECO:0000269\|PubMed:8756331, ECO:0000269\|PubMed:8939961, ECO:0000269\|PubMed:9395455, ECO:0000269\|PubMed:9488694, ECO:0000303\|PubMed:25173806, ECO:0000303\|PubMed:29516132}.; FUNCTION: (Microbial infection) Through its interaction with HCV envelope glycoprotein E2, participates in the attachment of HCV to HSPGs and other receptors (LDLr, VLDLr, and SR-B1) on the cell surface and to the assembly, maturation and infectivity of HCV viral particles (PubMed:25122793, PubMed:29695434). This interaction is probably promoted via the up-regulation of cellular autophagy by the virus (PubMed:29695434). {ECO:0000269\|PubMed:25122793, ECO:0000269\|PubMed:29695434}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000263273

42_51

125

462.0

Region

Note=O-glycosylated at one site

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000405315

42_51

125

462.0

Region

Note=O-glycosylated at one site

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000407032

42_51

125

666.6666666666666

Region

Note=O-glycosylated at one site

Tgene

APOE

chr19:49409142

chr19:45411017

ENST00000252486

158_168

318.0

Region

LDL and other lipoprotein receptors binding

Tgene

APOE

chr19:49409142

chr19:45411017

ENST00000252486

162_165

318.0

Region

Heparin-binding

Tgene

APOE

chr19:49409142

chr19:45411017

ENST00000252486

210_290

318.0

Region

Lipid-binding and lipoprotein association

Tgene

APOE

chr19:49409142

chr19:45411017

ENST00000252486

229_236

318.0

Region

Heparin-binding

Tgene

APOE

chr19:49409142

chr19:45411017

ENST00000252486

266_317

318.0

Region

Homooligomerization

Tgene

APOE

chr19:49409142

chr19:45411017

ENST00000252486

278_290

318.0

Region

Specificity for association with VLDL

Tgene

APOE

chr19:49409142

chr19:45411017

ENST00000252486

80_255

318.0

Region

Note=8 X 22 AA approximate tandem repeats

Tgene

APOE

chr19:49409142

chr19:45411017

ENST00000252486

102_123

318.0

Repeat

Note=2

Tgene

APOE

chr19:49409142

chr19:45411017

ENST00000252486

124_145

318.0

Repeat

Note=3

Tgene

APOE

chr19:49409142

chr19:45411017

ENST00000252486

146_167

318.0

Repeat

Note=4

Tgene

APOE

chr19:49409142

chr19:45411017

ENST00000252486

168_189

318.0

Repeat

Note=5

Tgene

APOE

chr19:49409142

chr19:45411017

ENST00000252486

190_211

318.0

Repeat

Note=6

Tgene

APOE

chr19:49409142

chr19:45411017

ENST00000252486

212_233

318.0

Repeat

Note=7

Tgene

APOE

chr19:49409142

chr19:45411017

ENST00000252486

234_255

318.0

Repeat

Note=8

Tgene

APOE

chr19:49409142

chr19:45411017

ENST00000252486

80_101

318.0

Repeat

Note=1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000263273

253_264

125

462.0

Calcium binding

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000263273

305_316

125

462.0

Calcium binding

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000405315

253_264

125

462.0

Calcium binding

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000405315

305_316

125

462.0

Calcium binding

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000407032

253_264

125

666.6666666666666

Calcium binding

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000407032

305_316

125

666.6666666666666

Calcium binding

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000263273

150_218

125

462.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000263273

341_407

125

462.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000405315

150_218

125

462.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000405315

341_407

125

462.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000407032

150_218

125

666.6666666666666

Coiled coil

Ontology_term=ECO:0000255

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000407032

341_407

125

666.6666666666666

Coiled coil

Ontology_term=ECO:0000255

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000263273

401_407

125

462.0

Compositional bias

Note=Poly-Gln

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000405315

401_407

125

462.0

Compositional bias

Note=Poly-Gln

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000407032

401_407

125

666.6666666666666

Compositional bias

Note=Poly-Gln

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000263273

172_218

125

462.0

DNA binding

Ontology_term=ECO:0000255

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000405315

172_218

125

462.0

DNA binding

Ontology_term=ECO:0000255

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000407032

172_218

125

666.6666666666666

DNA binding

Ontology_term=ECO:0000255

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000263273

240_275

125

462.0

Domain

EF-hand 1

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000263273

292_327

125

462.0

Domain

EF-hand 2

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000405315

240_275

125

462.0

Domain

EF-hand 1

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000405315

292_327

125

462.0

Domain

EF-hand 2

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000407032

240_275

125

666.6666666666666

Domain

EF-hand 1

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000407032

292_327

125

666.6666666666666

Domain

EF-hand 2

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000263273

303_333

125

462.0

Motif

GBA

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000405315

303_333

125

462.0

Motif

GBA

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000407032

303_333

125

666.6666666666666

Motif

GBA

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000263273

228_321

125

462.0

Region

Binds to GNAI2 and GNAI3

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000405315

228_321

125

462.0

Region

Binds to GNAI2 and GNAI3

Hgene

NUCB1

chr19:49409142

chr19:45411017

ENST00000407032

228_321

125

666.6666666666666

Region

Binds to GNAI2 and GNAI3

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Fusion Gene Sequence for NUCB1-APOE

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>60752_60752_1_NUCB1-APOE_NUCB1_chr19_49409142_ENST00000263273_APOE_chr19_45411017_ENST00000252486_length(transcript)=1443nt_BP=389nt
AGACCACACTGCCATGCCTCCCTCTGGGCCCCGAGGAACCCTCCTTCTGTTGCCGCTGCTGCTGCTGCTCCTGCTTCGCGCCGTGCTGGC
TGTCCCCCTGGAGCGAGGGGCGCCCAACAAGGAGGAGACCCCTGCGACTGAGAGTCCCGACACAGGCCTGTACTACCACCGGTACCTCCA
GGAGGTCATCGATGTACTGGAGACGGATGGGCATTTCCGAGAGAAGCTGCAGGCTGCCAATGCGGAGGACATCAAGAGCGGGAAGCTGAG
CCGAGAGCTGGACTTTGTCAGCCACCACGTCCGCACCAAGCTGGATGAGCTCAAGCGACAGGAGGTGTCACGGCTGCGGATGCTGCTCAA
GGCCAAGATGGACGCCGAGCAGGATCCCAGATGCCAGGCCAAGGTGGAGCAAGCGGTGGAGACAGAGCCGGAGCCCGAGCTGCGCCAGCA
GACCGAGTGGCAGAGCGGCCAGCGCTGGGAACTGGCACTGGGTCGCTTTTGGGATTACCTGCGCTGGGTGCAGACACTGTCTGAGCAGGT
GCAGGAGGAGCTGCTCAGCTCCCAGGTCACCCAGGAACTGAGGGCGCTGATGGACGAGACCATGAAGGAGTTGAAGGCCTACAAATCGGA
ACTGGAGGAACAACTGACCCCGGTGGCGGAGGAGACGCGGGCACGGCTGTCCAAGGAGCTGCAGGCGGCGCAGGCCCGGCTGGGCGCGGA
CATGGAGGACGTGTGCGGCCGCCTGGTGCAGTACCGCGGCGAGGTGCAGGCCATGCTCGGCCAGAGCACCGAGGAGCTGCGGGTGCGCCT
CGCCTCCCACCTGCGCAAGCTGCGTAAGCGGCTCCTCCGCGATGCCGATGACCTGCAGAAGCGCCTGGCAGTGTACCAGGCCGGGGCCCG
CGAGGGCGCCGAGCGCGGCCTCAGCGCCATCCGCGAGCGCCTGGGGCCCCTGGTGGAACAGGGCCGCGTGCGGGCCGCCACTGTGGGCTC
CCTGGCCGGCCAGCCGCTACAGGAGCGGGCCCAGGCCTGGGGCGAGCGGCTGCGCGCGCGGATGGAGGAGATGGGCAGCCGGACCCGCGA
CCGCCTGGACGAGGTGAAGGAGCAGGTGGCGGAGGTGCGCGCCAAGCTGGAGGAGCAGGCCCAGCAGATACGCCTGCAGGCCGAGGCCTT
CCAGGCCCGCCTCAAGAGCTGGTTCGAGCCCCTGGTGGAAGACATGCAGCGCCAGTGGGCCGGGCTGGTGGAGAAGGTGCAGGCTGCCGT
GGGCACCAGCGCCGCCCCTGTGCCCAGCGACAATCACTGAACGCCGAAGCCTGCAGCCATGCGACCCCACGCCACCCCGTGCCTCCTGCC
TCCGCGCAGCCTGCAGCGGGAGACCCTGTCCCCGCCCCAGCCGTCCTCCTGGGGTGGACCCTAGTTTAATAAAGATTCACCAAGTTTCAC

>60752_60752_1_NUCB1-APOE_NUCB1_chr19_49409142_ENST00000263273_APOE_chr19_45411017_ENST00000252486_length(amino acids)=428AA_BP=126
MPPSGPRGTLLLLPLLLLLLLRAVLAVPLERGAPNKEETPATESPDTGLYYHRYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELD
FVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPRCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEEL
LSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHL
RKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDE

--------------------------------------------------------------
>60752_60752_2_NUCB1-APOE_NUCB1_chr19_49409142_ENST00000405315_APOE_chr19_45411017_ENST00000252486_length(transcript)=1764nt_BP=710nt
GCGGAAGTTATTTTTCCCCCGGCCGGCAGGGAGTTGTAGTTATCTTTGAAAGCCTTCTCTCTCTTTTGGCATAGGCGGGAAATGTGGCGT
CAAGAGGCTGGGATTCCGAGAAAGAAGCGAGGCTTTCACGAAAATGCGAGCGGCTTCGGCAAGGGGCGGGGCCGCTGGACGTGGATGAAA
GCTACAGAGCCAGCGTGGACCAATCAGACCTCTTTGGGGCGGGGCCTCTGTGGATAAGTGGGCGTGGTCTAGGGGGGAAGTCACCAAGAA
CGCACCGGAGGTCCTTGCCCGCCCTGGAAAACGCCCTCTGCGGTGAAGGAGAGACCACACTGCCATGCCTCCCTCTGGGCCCCGAGGAAC
CCTCCTTCTGTTGCCGCTGCTGCTGCTGCTCCTGCTTCGCGCCGTGCTGGCTGTCCCCCTGGAGCGAGGGGCGCCCAACAAGGAGGAGAC
CCCTGCGACTGAGAGTCCCGACACAGGCCTGTACTACCACCGGTACCTCCAGGAGGTCATCGATGTACTGGAGACGGATGGGCATTTCCG
AGAGAAGCTGCAGGCTGCCAATGCGGAGGACATCAAGAGCGGGAAGCTGAGCCGAGAGCTGGACTTTGTCAGCCACCACGTCCGCACCAA
GCTGGATGAGCTCAAGCGACAGGAGGTGTCACGGCTGCGGATGCTGCTCAAGGCCAAGATGGACGCCGAGCAGGATCCCAGATGCCAGGC
CAAGGTGGAGCAAGCGGTGGAGACAGAGCCGGAGCCCGAGCTGCGCCAGCAGACCGAGTGGCAGAGCGGCCAGCGCTGGGAACTGGCACT
GGGTCGCTTTTGGGATTACCTGCGCTGGGTGCAGACACTGTCTGAGCAGGTGCAGGAGGAGCTGCTCAGCTCCCAGGTCACCCAGGAACT
GAGGGCGCTGATGGACGAGACCATGAAGGAGTTGAAGGCCTACAAATCGGAACTGGAGGAACAACTGACCCCGGTGGCGGAGGAGACGCG
GGCACGGCTGTCCAAGGAGCTGCAGGCGGCGCAGGCCCGGCTGGGCGCGGACATGGAGGACGTGTGCGGCCGCCTGGTGCAGTACCGCGG
CGAGGTGCAGGCCATGCTCGGCCAGAGCACCGAGGAGCTGCGGGTGCGCCTCGCCTCCCACCTGCGCAAGCTGCGTAAGCGGCTCCTCCG
CGATGCCGATGACCTGCAGAAGCGCCTGGCAGTGTACCAGGCCGGGGCCCGCGAGGGCGCCGAGCGCGGCCTCAGCGCCATCCGCGAGCG
CCTGGGGCCCCTGGTGGAACAGGGCCGCGTGCGGGCCGCCACTGTGGGCTCCCTGGCCGGCCAGCCGCTACAGGAGCGGGCCCAGGCCTG
GGGCGAGCGGCTGCGCGCGCGGATGGAGGAGATGGGCAGCCGGACCCGCGACCGCCTGGACGAGGTGAAGGAGCAGGTGGCGGAGGTGCG
CGCCAAGCTGGAGGAGCAGGCCCAGCAGATACGCCTGCAGGCCGAGGCCTTCCAGGCCCGCCTCAAGAGCTGGTTCGAGCCCCTGGTGGA
AGACATGCAGCGCCAGTGGGCCGGGCTGGTGGAGAAGGTGCAGGCTGCCGTGGGCACCAGCGCCGCCCCTGTGCCCAGCGACAATCACTG
AACGCCGAAGCCTGCAGCCATGCGACCCCACGCCACCCCGTGCCTCCTGCCTCCGCGCAGCCTGCAGCGGGAGACCCTGTCCCCGCCCCA

>60752_60752_2_NUCB1-APOE_NUCB1_chr19_49409142_ENST00000405315_APOE_chr19_45411017_ENST00000252486_length(amino acids)=428AA_BP=126
MPPSGPRGTLLLLPLLLLLLLRAVLAVPLERGAPNKEETPATESPDTGLYYHRYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELD
FVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPRCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEEL
LSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHL
RKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDE

--------------------------------------------------------------
>60752_60752_3_NUCB1-APOE_NUCB1_chr19_49409142_ENST00000407032_APOE_chr19_45411017_ENST00000252486_length(transcript)=1494nt_BP=440nt
CGCACCGGAGGTCCTTGCCCGCCCTGGAAAACGCCCTCTGCGGTGAAGGAGAGACCACACTGCCATGCCTCCCTCTGGGCCCCGAGGAAC
CCTCCTTCTGTTGCCGCTGCTGCTGCTGCTCCTGCTTCGCGCCGTGCTGGCTGTCCCCCTGGAGCGAGGGGCGCCCAACAAGGAGGAGAC
CCCTGCGACTGAGAGTCCCGACACAGGCCTGTACTACCACCGGTACCTCCAGGAGGTCATCGATGTACTGGAGACGGATGGGCATTTCCG
AGAGAAGCTGCAGGCTGCCAATGCGGAGGACATCAAGAGCGGGAAGCTGAGCCGAGAGCTGGACTTTGTCAGCCACCACGTCCGCACCAA
GCTGGATGAGCTCAAGCGACAGGAGGTGTCACGGCTGCGGATGCTGCTCAAGGCCAAGATGGACGCCGAGCAGGATCCCAGATGCCAGGC
CAAGGTGGAGCAAGCGGTGGAGACAGAGCCGGAGCCCGAGCTGCGCCAGCAGACCGAGTGGCAGAGCGGCCAGCGCTGGGAACTGGCACT
GGGTCGCTTTTGGGATTACCTGCGCTGGGTGCAGACACTGTCTGAGCAGGTGCAGGAGGAGCTGCTCAGCTCCCAGGTCACCCAGGAACT
GAGGGCGCTGATGGACGAGACCATGAAGGAGTTGAAGGCCTACAAATCGGAACTGGAGGAACAACTGACCCCGGTGGCGGAGGAGACGCG
GGCACGGCTGTCCAAGGAGCTGCAGGCGGCGCAGGCCCGGCTGGGCGCGGACATGGAGGACGTGTGCGGCCGCCTGGTGCAGTACCGCGG
CGAGGTGCAGGCCATGCTCGGCCAGAGCACCGAGGAGCTGCGGGTGCGCCTCGCCTCCCACCTGCGCAAGCTGCGTAAGCGGCTCCTCCG
CGATGCCGATGACCTGCAGAAGCGCCTGGCAGTGTACCAGGCCGGGGCCCGCGAGGGCGCCGAGCGCGGCCTCAGCGCCATCCGCGAGCG
CCTGGGGCCCCTGGTGGAACAGGGCCGCGTGCGGGCCGCCACTGTGGGCTCCCTGGCCGGCCAGCCGCTACAGGAGCGGGCCCAGGCCTG
GGGCGAGCGGCTGCGCGCGCGGATGGAGGAGATGGGCAGCCGGACCCGCGACCGCCTGGACGAGGTGAAGGAGCAGGTGGCGGAGGTGCG
CGCCAAGCTGGAGGAGCAGGCCCAGCAGATACGCCTGCAGGCCGAGGCCTTCCAGGCCCGCCTCAAGAGCTGGTTCGAGCCCCTGGTGGA
AGACATGCAGCGCCAGTGGGCCGGGCTGGTGGAGAAGGTGCAGGCTGCCGTGGGCACCAGCGCCGCCCCTGTGCCCAGCGACAATCACTG
AACGCCGAAGCCTGCAGCCATGCGACCCCACGCCACCCCGTGCCTCCTGCCTCCGCGCAGCCTGCAGCGGGAGACCCTGTCCCCGCCCCA

>60752_60752_3_NUCB1-APOE_NUCB1_chr19_49409142_ENST00000407032_APOE_chr19_45411017_ENST00000252486_length(amino acids)=428AA_BP=126
MPPSGPRGTLLLLPLLLLLLLRAVLAVPLERGAPNKEETPATESPDTGLYYHRYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELD
FVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPRCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEEL
LSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHL
RKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDE

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Fusion Gene PPI Analysis for NUCB1-APOE

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for NUCB1-APOE

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for NUCB1-APOE

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source