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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NUCKS1-SDCCAG8 (FusionGDB2 ID:60785)

Fusion Gene Summary for NUCKS1-SDCCAG8

check button Fusion gene summary
Fusion gene informationFusion gene name: NUCKS1-SDCCAG8
Fusion gene ID: 60785
HgeneTgene
Gene symbol

NUCKS1

SDCCAG8

Gene ID

64710

10806

Gene namenuclear casein kinase and cyclin dependent kinase substrate 1SHH signaling and ciliogenesis regulator SDCCAG8
SynonymsJC7|NUCKSBBS16|CCCAP|CCCAP SLSN7|HSPC085|NPHP10|NY-CO-8|SLSN7|hCCCAP
Cytomap

1q32.1

1q43-q44

Type of geneprotein-codingprotein-coding
Descriptionnuclear ubiquitous casein and cyclin-dependent kinase substrate 1P1nuclear ubiquitous casein kinase and cyclin-dependent kinase substratepotential LAG1 interactorserologically defined colon cancer antigen 8Bardet-Biedl syndrome 16antigen NY-CO-8centrosomal colon cancer autoantigen proteinnephrocystin 10
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000367142, ENST00000464938, 
ENST00000391846, ENST00000496361, 
ENST00000343783, ENST00000355875, 
ENST00000366541, 
Fusion gene scores* DoF score22 X 24 X 7=369622 X 19 X 10=4180
# samples 3226
** MAII scorelog2(32/3696*10)=-3.52982094652869
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/4180*10)=-4.00691941393979
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NUCKS1 [Title/Abstract] AND SDCCAG8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNUCKS1(205696828)-SDCCAG8(243579004), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNUCKS1

GO:0031297

replication fork processing

26323318


check buttonFusion gene breakpoints across NUCKS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SDCCAG8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-N9-A4PZ-01ANUCKS1chr1

205696828

-SDCCAG8chr1

243579004

+
ChimerDB4UCSTCGA-N9-A4PZNUCKS1chr1

205696827

-SDCCAG8chr1

243579003

+


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Fusion Gene ORF analysis for NUCKS1-SDCCAG8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000367142ENST00000391846NUCKS1chr1

205696828

-SDCCAG8chr1

243579004

+
5CDS-intronENST00000367142ENST00000391846NUCKS1chr1

205696827

-SDCCAG8chr1

243579003

+
5CDS-intronENST00000367142ENST00000496361NUCKS1chr1

205696828

-SDCCAG8chr1

243579004

+
5CDS-intronENST00000367142ENST00000496361NUCKS1chr1

205696827

-SDCCAG8chr1

243579003

+
In-frameENST00000367142ENST00000343783NUCKS1chr1

205696828

-SDCCAG8chr1

243579004

+
In-frameENST00000367142ENST00000343783NUCKS1chr1

205696827

-SDCCAG8chr1

243579003

+
In-frameENST00000367142ENST00000355875NUCKS1chr1

205696828

-SDCCAG8chr1

243579004

+
In-frameENST00000367142ENST00000355875NUCKS1chr1

205696827

-SDCCAG8chr1

243579003

+
In-frameENST00000367142ENST00000366541NUCKS1chr1

205696828

-SDCCAG8chr1

243579004

+
In-frameENST00000367142ENST00000366541NUCKS1chr1

205696827

-SDCCAG8chr1

243579003

+
intron-3CDSENST00000464938ENST00000343783NUCKS1chr1

205696828

-SDCCAG8chr1

243579004

+
intron-3CDSENST00000464938ENST00000343783NUCKS1chr1

205696827

-SDCCAG8chr1

243579003

+
intron-3CDSENST00000464938ENST00000355875NUCKS1chr1

205696828

-SDCCAG8chr1

243579004

+
intron-3CDSENST00000464938ENST00000355875NUCKS1chr1

205696827

-SDCCAG8chr1

243579003

+
intron-3CDSENST00000464938ENST00000366541NUCKS1chr1

205696828

-SDCCAG8chr1

243579004

+
intron-3CDSENST00000464938ENST00000366541NUCKS1chr1

205696827

-SDCCAG8chr1

243579003

+
intron-intronENST00000464938ENST00000391846NUCKS1chr1

205696828

-SDCCAG8chr1

243579004

+
intron-intronENST00000464938ENST00000391846NUCKS1chr1

205696827

-SDCCAG8chr1

243579003

+
intron-intronENST00000464938ENST00000496361NUCKS1chr1

205696828

-SDCCAG8chr1

243579004

+
intron-intronENST00000464938ENST00000496361NUCKS1chr1

205696827

-SDCCAG8chr1

243579003

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367142NUCKS1chr1205696828-ENST00000355875SDCCAG8chr1243579004+13034761441001285
ENST00000367142NUCKS1chr1205696828-ENST00000366541SDCCAG8chr1243579004+13094761441001285
ENST00000367142NUCKS1chr1205696828-ENST00000343783SDCCAG8chr1243579004+13074761441001285
ENST00000367142NUCKS1chr1205696827-ENST00000355875SDCCAG8chr1243579003+13034761441001285
ENST00000367142NUCKS1chr1205696827-ENST00000366541SDCCAG8chr1243579003+13094761441001285
ENST00000367142NUCKS1chr1205696827-ENST00000343783SDCCAG8chr1243579003+13074761441001285

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367142ENST00000355875NUCKS1chr1205696828-SDCCAG8chr1243579004+0.0041860310.9958139
ENST00000367142ENST00000366541NUCKS1chr1205696828-SDCCAG8chr1243579004+0.0042188140.9957812
ENST00000367142ENST00000343783NUCKS1chr1205696828-SDCCAG8chr1243579004+0.0042064590.9957936
ENST00000367142ENST00000355875NUCKS1chr1205696827-SDCCAG8chr1243579003+0.0041860310.9958139
ENST00000367142ENST00000366541NUCKS1chr1205696827-SDCCAG8chr1243579003+0.0042188140.9957812
ENST00000367142ENST00000343783NUCKS1chr1205696827-SDCCAG8chr1243579003+0.0042064590.9957936

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Fusion Genomic Features for NUCKS1-SDCCAG8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NUCKS1chr1205696827-SDCCAG8chr1243579003+4.66E-091
NUCKS1chr1205696827-SDCCAG8chr1243579003+4.66E-091
NUCKS1chr1205696827-SDCCAG8chr1243579003+4.66E-091
NUCKS1chr1205696827-SDCCAG8chr1243579003+4.66E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NUCKS1-SDCCAG8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:205696828/chr1:243579004)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSDCCAG8chr1:205696827chr1:243579003ENST00000391846010129_1750361.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr1:205696827chr1:243579003ENST00000391846010223_2730361.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr1:205696827chr1:243579003ENST00000391846010348_7070361.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr1:205696828chr1:243579004ENST00000391846010129_1750361.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr1:205696828chr1:243579004ENST00000391846010223_2730361.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr1:205696828chr1:243579004ENST00000391846010348_7070361.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr1:205696827chr1:243579003ENST00000391846010534_6920361.0Compositional biasNote=Gln-rich
TgeneSDCCAG8chr1:205696828chr1:243579004ENST00000391846010534_6920361.0Compositional biasNote=Gln-rich
TgeneSDCCAG8chr1:205696827chr1:243579003ENST00000391846010216_7130361.0RegionSufficient for homodimerization
TgeneSDCCAG8chr1:205696828chr1:243579004ENST00000391846010216_7130361.0RegionSufficient for homodimerization

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNUCKS1chr1:205696827chr1:243579003ENST00000367142-37140_14557244.0Compositional biasNote=Poly-Asp
HgeneNUCKS1chr1:205696827chr1:243579003ENST00000367142-37150_20657244.0Compositional biasNote=Lys-rich
HgeneNUCKS1chr1:205696828chr1:243579004ENST00000367142-37140_14557244.0Compositional biasNote=Poly-Asp
HgeneNUCKS1chr1:205696828chr1:243579004ENST00000367142-37150_20657244.0Compositional biasNote=Lys-rich
TgeneSDCCAG8chr1:205696827chr1:243579003ENST000003665411218129_175538714.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr1:205696827chr1:243579003ENST000003665411218223_273538714.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr1:205696827chr1:243579003ENST000003665411218348_707538714.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr1:205696828chr1:243579004ENST000003665411218129_175538714.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr1:205696828chr1:243579004ENST000003665411218223_273538714.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr1:205696828chr1:243579004ENST000003665411218348_707538714.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr1:205696827chr1:243579003ENST000003665411218534_692538714.0Compositional biasNote=Gln-rich
TgeneSDCCAG8chr1:205696828chr1:243579004ENST000003665411218534_692538714.0Compositional biasNote=Gln-rich
TgeneSDCCAG8chr1:205696827chr1:243579003ENST000003665411218216_713538714.0RegionSufficient for homodimerization
TgeneSDCCAG8chr1:205696828chr1:243579004ENST000003665411218216_713538714.0RegionSufficient for homodimerization


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Fusion Gene Sequence for NUCKS1-SDCCAG8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>60785_60785_1_NUCKS1-SDCCAG8_NUCKS1_chr1_205696827_ENST00000367142_SDCCAG8_chr1_243579003_ENST00000343783_length(transcript)=1307nt_BP=476nt
GTCTCCAATGAGCAGGCGTGTTGGGGAGGAGCGCACAAACCCTAGTGGGTTTGGTTGCACGGCGGCTTTGGCGCATTTTCGGCTGGTTTG
ATTCATCCATTTTGAAGAGACGGGGGAGCGGGGGGCTCGTCTGTTCCAGGAGCCCTGAACCAAAGAGCAGCGGAGTTTGAGAAGCCAGCA
GCTCGGGGTTCGGCAGCAGCGGTCCCATCGGCTGAAGTTCGGGGGGGGTGGGGCGCCGAGCGCGCGGGGTGGGGGGGGTCCTGGTCTTTG
GCTTCTCGACTCGGTCCTGTTTCGACAGCGAACATGTCGCGGCCTGTCAGAAATAGGAAGGTTGTTGATTACTCACAGTTTCAGGAATCT
GATGATGCAGATGAAGATTATGGAAGAGATTCGGGCCCTCCCACTAAGAAAATTCGATCATCTCCCCGAGAAGCTAAAAATAAGAGGCGA
TCTGGAAAGAATTCACAGGAAGATAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCC
CAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACC
TCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAA
ATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTC
CAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTC
CTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAA
TCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAA
CGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGG
CTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTC

>60785_60785_1_NUCKS1-SDCCAG8_NUCKS1_chr1_205696827_ENST00000367142_SDCCAG8_chr1_243579003_ENST00000343783_length(amino acids)=285AA_BP=110
MNQRAAEFEKPAARGSAAAVPSAEVRGGWGAERAGWGGSWSLASRLGPVSTANMSRPVRNRKVVDYSQFQESDDADEDYGRDSGPPTKKI
RSSPREAKNKRRSGKNSQEDRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAK
KLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEV

--------------------------------------------------------------
>60785_60785_2_NUCKS1-SDCCAG8_NUCKS1_chr1_205696827_ENST00000367142_SDCCAG8_chr1_243579003_ENST00000355875_length(transcript)=1303nt_BP=476nt
GTCTCCAATGAGCAGGCGTGTTGGGGAGGAGCGCACAAACCCTAGTGGGTTTGGTTGCACGGCGGCTTTGGCGCATTTTCGGCTGGTTTG
ATTCATCCATTTTGAAGAGACGGGGGAGCGGGGGGCTCGTCTGTTCCAGGAGCCCTGAACCAAAGAGCAGCGGAGTTTGAGAAGCCAGCA
GCTCGGGGTTCGGCAGCAGCGGTCCCATCGGCTGAAGTTCGGGGGGGGTGGGGCGCCGAGCGCGCGGGGTGGGGGGGGTCCTGGTCTTTG
GCTTCTCGACTCGGTCCTGTTTCGACAGCGAACATGTCGCGGCCTGTCAGAAATAGGAAGGTTGTTGATTACTCACAGTTTCAGGAATCT
GATGATGCAGATGAAGATTATGGAAGAGATTCGGGCCCTCCCACTAAGAAAATTCGATCATCTCCCCGAGAAGCTAAAAATAAGAGGCGA
TCTGGAAAGAATTCACAGGAAGATAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCC
CAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACC
TCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAA
ATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTC
CAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTC
CTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAA
TCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAA
CGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGG
CTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTC

>60785_60785_2_NUCKS1-SDCCAG8_NUCKS1_chr1_205696827_ENST00000367142_SDCCAG8_chr1_243579003_ENST00000355875_length(amino acids)=285AA_BP=110
MNQRAAEFEKPAARGSAAAVPSAEVRGGWGAERAGWGGSWSLASRLGPVSTANMSRPVRNRKVVDYSQFQESDDADEDYGRDSGPPTKKI
RSSPREAKNKRRSGKNSQEDRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAK
KLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEV

--------------------------------------------------------------
>60785_60785_3_NUCKS1-SDCCAG8_NUCKS1_chr1_205696827_ENST00000367142_SDCCAG8_chr1_243579003_ENST00000366541_length(transcript)=1309nt_BP=476nt
GTCTCCAATGAGCAGGCGTGTTGGGGAGGAGCGCACAAACCCTAGTGGGTTTGGTTGCACGGCGGCTTTGGCGCATTTTCGGCTGGTTTG
ATTCATCCATTTTGAAGAGACGGGGGAGCGGGGGGCTCGTCTGTTCCAGGAGCCCTGAACCAAAGAGCAGCGGAGTTTGAGAAGCCAGCA
GCTCGGGGTTCGGCAGCAGCGGTCCCATCGGCTGAAGTTCGGGGGGGGTGGGGCGCCGAGCGCGCGGGGTGGGGGGGGTCCTGGTCTTTG
GCTTCTCGACTCGGTCCTGTTTCGACAGCGAACATGTCGCGGCCTGTCAGAAATAGGAAGGTTGTTGATTACTCACAGTTTCAGGAATCT
GATGATGCAGATGAAGATTATGGAAGAGATTCGGGCCCTCCCACTAAGAAAATTCGATCATCTCCCCGAGAAGCTAAAAATAAGAGGCGA
TCTGGAAAGAATTCACAGGAAGATAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCC
CAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACC
TCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAA
ATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTC
CAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTC
CTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAA
TCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAA
CGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGG
CTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTC

>60785_60785_3_NUCKS1-SDCCAG8_NUCKS1_chr1_205696827_ENST00000367142_SDCCAG8_chr1_243579003_ENST00000366541_length(amino acids)=285AA_BP=110
MNQRAAEFEKPAARGSAAAVPSAEVRGGWGAERAGWGGSWSLASRLGPVSTANMSRPVRNRKVVDYSQFQESDDADEDYGRDSGPPTKKI
RSSPREAKNKRRSGKNSQEDRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAK
KLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEV

--------------------------------------------------------------
>60785_60785_4_NUCKS1-SDCCAG8_NUCKS1_chr1_205696828_ENST00000367142_SDCCAG8_chr1_243579004_ENST00000343783_length(transcript)=1307nt_BP=476nt
GTCTCCAATGAGCAGGCGTGTTGGGGAGGAGCGCACAAACCCTAGTGGGTTTGGTTGCACGGCGGCTTTGGCGCATTTTCGGCTGGTTTG
ATTCATCCATTTTGAAGAGACGGGGGAGCGGGGGGCTCGTCTGTTCCAGGAGCCCTGAACCAAAGAGCAGCGGAGTTTGAGAAGCCAGCA
GCTCGGGGTTCGGCAGCAGCGGTCCCATCGGCTGAAGTTCGGGGGGGGTGGGGCGCCGAGCGCGCGGGGTGGGGGGGGTCCTGGTCTTTG
GCTTCTCGACTCGGTCCTGTTTCGACAGCGAACATGTCGCGGCCTGTCAGAAATAGGAAGGTTGTTGATTACTCACAGTTTCAGGAATCT
GATGATGCAGATGAAGATTATGGAAGAGATTCGGGCCCTCCCACTAAGAAAATTCGATCATCTCCCCGAGAAGCTAAAAATAAGAGGCGA
TCTGGAAAGAATTCACAGGAAGATAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCC
CAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACC
TCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAA
ATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTC
CAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTC
CTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAA
TCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAA
CGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGG
CTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTC

>60785_60785_4_NUCKS1-SDCCAG8_NUCKS1_chr1_205696828_ENST00000367142_SDCCAG8_chr1_243579004_ENST00000343783_length(amino acids)=285AA_BP=110
MNQRAAEFEKPAARGSAAAVPSAEVRGGWGAERAGWGGSWSLASRLGPVSTANMSRPVRNRKVVDYSQFQESDDADEDYGRDSGPPTKKI
RSSPREAKNKRRSGKNSQEDRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAK
KLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEV

--------------------------------------------------------------
>60785_60785_5_NUCKS1-SDCCAG8_NUCKS1_chr1_205696828_ENST00000367142_SDCCAG8_chr1_243579004_ENST00000355875_length(transcript)=1303nt_BP=476nt
GTCTCCAATGAGCAGGCGTGTTGGGGAGGAGCGCACAAACCCTAGTGGGTTTGGTTGCACGGCGGCTTTGGCGCATTTTCGGCTGGTTTG
ATTCATCCATTTTGAAGAGACGGGGGAGCGGGGGGCTCGTCTGTTCCAGGAGCCCTGAACCAAAGAGCAGCGGAGTTTGAGAAGCCAGCA
GCTCGGGGTTCGGCAGCAGCGGTCCCATCGGCTGAAGTTCGGGGGGGGTGGGGCGCCGAGCGCGCGGGGTGGGGGGGGTCCTGGTCTTTG
GCTTCTCGACTCGGTCCTGTTTCGACAGCGAACATGTCGCGGCCTGTCAGAAATAGGAAGGTTGTTGATTACTCACAGTTTCAGGAATCT
GATGATGCAGATGAAGATTATGGAAGAGATTCGGGCCCTCCCACTAAGAAAATTCGATCATCTCCCCGAGAAGCTAAAAATAAGAGGCGA
TCTGGAAAGAATTCACAGGAAGATAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCC
CAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACC
TCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAA
ATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTC
CAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTC
CTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAA
TCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAA
CGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGG
CTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTC

>60785_60785_5_NUCKS1-SDCCAG8_NUCKS1_chr1_205696828_ENST00000367142_SDCCAG8_chr1_243579004_ENST00000355875_length(amino acids)=285AA_BP=110
MNQRAAEFEKPAARGSAAAVPSAEVRGGWGAERAGWGGSWSLASRLGPVSTANMSRPVRNRKVVDYSQFQESDDADEDYGRDSGPPTKKI
RSSPREAKNKRRSGKNSQEDRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAK
KLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEV

--------------------------------------------------------------
>60785_60785_6_NUCKS1-SDCCAG8_NUCKS1_chr1_205696828_ENST00000367142_SDCCAG8_chr1_243579004_ENST00000366541_length(transcript)=1309nt_BP=476nt
GTCTCCAATGAGCAGGCGTGTTGGGGAGGAGCGCACAAACCCTAGTGGGTTTGGTTGCACGGCGGCTTTGGCGCATTTTCGGCTGGTTTG
ATTCATCCATTTTGAAGAGACGGGGGAGCGGGGGGCTCGTCTGTTCCAGGAGCCCTGAACCAAAGAGCAGCGGAGTTTGAGAAGCCAGCA
GCTCGGGGTTCGGCAGCAGCGGTCCCATCGGCTGAAGTTCGGGGGGGGTGGGGCGCCGAGCGCGCGGGGTGGGGGGGGTCCTGGTCTTTG
GCTTCTCGACTCGGTCCTGTTTCGACAGCGAACATGTCGCGGCCTGTCAGAAATAGGAAGGTTGTTGATTACTCACAGTTTCAGGAATCT
GATGATGCAGATGAAGATTATGGAAGAGATTCGGGCCCTCCCACTAAGAAAATTCGATCATCTCCCCGAGAAGCTAAAAATAAGAGGCGA
TCTGGAAAGAATTCACAGGAAGATAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCC
CAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACC
TCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAA
ATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTC
CAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTC
CTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAA
TCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAA
CGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGG
CTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTC

>60785_60785_6_NUCKS1-SDCCAG8_NUCKS1_chr1_205696828_ENST00000367142_SDCCAG8_chr1_243579004_ENST00000366541_length(amino acids)=285AA_BP=110
MNQRAAEFEKPAARGSAAAVPSAEVRGGWGAERAGWGGSWSLASRLGPVSTANMSRPVRNRKVVDYSQFQESDDADEDYGRDSGPPTKKI
RSSPREAKNKRRSGKNSQEDRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAK
KLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NUCKS1-SDCCAG8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NUCKS1-SDCCAG8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NUCKS1-SDCCAG8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource