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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NUDCD1-VWA8 (FusionGDB2 ID:60803)

Fusion Gene Summary for NUDCD1-VWA8

Fusion gene summary

Fusion gene information	Fusion gene name: NUDCD1-VWA8
	Fusion gene ID: 60803
		Hgene	Tgene
	Gene symbol	NUDCD1	VWA8
	Gene ID	84955	23078
	Gene name	NudC domain containing 1	von Willebrand factor A domain containing 8
	Synonyms	CML66\|OVA66	KIAA0564\|P7BP2
	Cytomap	8q23.1	13q14.11
	Type of gene	protein-coding	protein-coding
	Description	nudC domain-containing protein 1chronic myelogenous leukemia tumor antigen 66tumor antigen CML66	von Willebrand factor A domain-containing protein 8PEX7-binding protein 2
	Modification date	20200313	20200313
	UniProtAcc	.	A3KMH1
	Ensembl transtripts involved in fusion gene	ENST00000239690, ENST00000427660,	ENST00000281496, ENST00000478987, ENST00000379310,
Fusion gene scores	* DoF score	8 X 5 X 5=200	6 X 6 X 6=216
	# samples	8	6
	** MAII score	log2(8/200*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/216*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NUDCD1 [Title/Abstract] AND VWA8 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NUDCD1(110283234)-VWA8(42189220), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across NUDCD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across VWA8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-24-1557-01A	NUDCD1	chr8	110283234	-	VWA8	chr13	42189220	-

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Fusion Gene ORF analysis for NUDCD1-VWA8

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000239690	ENST00000281496	NUDCD1	chr8	110283234	-	VWA8	chr13	42189220	-
5CDS-intron	ENST00000239690	ENST00000478987	NUDCD1	chr8	110283234	-	VWA8	chr13	42189220	-
5CDS-intron	ENST00000427660	ENST00000281496	NUDCD1	chr8	110283234	-	VWA8	chr13	42189220	-
5CDS-intron	ENST00000427660	ENST00000478987	NUDCD1	chr8	110283234	-	VWA8	chr13	42189220	-
In-frame	ENST00000239690	ENST00000379310	NUDCD1	chr8	110283234	-	VWA8	chr13	42189220	-
In-frame	ENST00000427660	ENST00000379310	NUDCD1	chr8	110283234	-	VWA8	chr13	42189220	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000239690	NUDCD1	chr8	110283234	-	ENST00000379310	VWA8	chr13	42189220	-	4141	1674	357	2780	807
ENST00000427660	NUDCD1	chr8	110283234	-	ENST00000379310	VWA8	chr13	42189220	-	3778	1311	99	2417	772

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000239690	ENST00000379310	NUDCD1	chr8	110283234	-	VWA8	chr13	42189220	-	0.000242528	0.99975747
ENST00000427660	ENST00000379310	NUDCD1	chr8	110283234	-	VWA8	chr13	42189220	-	0.000129936	0.99987006

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Fusion Genomic Features for NUDCD1-VWA8

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NUDCD1-VWA8

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:110283234/chr13:42189220)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	VWA8 A3KMH1
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Exhibits ATPase activity in vitro. {ECO:0000250\|UniProtKB:Q8CC88}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NUDCD1

chr8:110283234

chr13:42189220

ENST00000239690

273_361

433

584.0

Domain

Hgene

NUDCD1

chr8:110283234

chr13:42189220

ENST00000427660

273_361

404

555.0

Domain

Tgene

VWA8

chr8:110283234

chr13:42189220

ENST00000281496

1714_1896

1040.0

Domain

VWFA

Tgene

VWA8

chr8:110283234

chr13:42189220

ENST00000379310

1714_1896

1537

1906.0

Domain

VWFA

Tgene

VWA8

chr8:110283234

chr13:42189220

ENST00000281496

447_454

1040.0

Nucleotide binding

ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

VWA8

chr8:110283234

chr13:42189220

ENST00000379310

447_454

1537

1906.0

Nucleotide binding

ATP

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Fusion Gene Sequence for NUDCD1-VWA8

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>60803_60803_1_NUDCD1-VWA8_NUDCD1_chr8_110283234_ENST00000239690_VWA8_chr13_42189220_ENST00000379310_length(transcript)=4141nt_BP=1674nt
CGGACTTAGACCCTCAGTAGCTCGGGCACCTAAGCACACAGAAAGCTAGAACACGCATTTCCGGGGCGGGGTCTCGCCACCCTGCCTATA
ATGTGAGAATTTAACCAGCGCGGGCCGCCTCCTGGTTGCTAGGGCCTCTGGGTAACAGAGTTCAGACCTTGCCGTCGCGCGCGCGTTAAG
TACCAGGAGAACTACATAGCCCAGCATGCAACAGTCTCAACTTTTTCACGGACACTACATTTCCCAGAAGGCAGTTCGCACCGCAGTGTT
TTCTGGGATGGGAACCACGCCGCTTCCCAGTCTCTGTGCGAGGCGTGAAGCGCGGACCTTTCAACAAGGGCTTTATTAATTCTCACGCTG
CGGCCCTGGAAAGCGATGGAGGTGGCGGCTAATTGCTCCCTACGGGTGAAGAGACCTCTGTTGGATCCCCGCTTCGAGGGTTACAAGCTC
TCTCTTGAGCCGCTGCCTTGTTACCAGCTGGAGCTTGACGCAGCTGTGGCAGAGGTAAAACTTCGAGATGATCAATATACACTGGAACAC
ATGCATGCTTTTGGAATGTATAATTACCTGCACTGTGATTCATGGTATCAAGACAGTGTCTACTATATTGATACCCTTGGAAGAATTATG
AATTTAACAGTAATGCTGGACACTGCCTTAGGAAAACCACGAGAGGTGTTTCGACTTCCTACAGATTTGACAGCATGTGACAACCGTCTT
TGTGCATCTATCCATTTCTCATCTTCTACCTGGGTTACCTTGTCAGATGGAACTGGAAGATTGTATGTCATTGGAACAGGTGAACGTGGA
AATAGCGCTTCTGAAAAATGGGAGATTATGTTTAATGAAGAACTTGGGGATCCTTTTATTATAATTCACAGTATCTCACTGCTAAATGCT
GAAGAACATTCTATAGCTACCCTACTTCTTCGAATAGAGAAAGAGGAATTGGATATGAAAGGAAGTGGTTTCTATGTTTCTCTGGAGTGG
GTCACTATCAGTAAGAAAAATCAAGATAATAAAAAATATGAAATTATTAAGCGTGATATTCTCCGTGGAAAGTCAGTGCCACATTATGCT
GCTATTGAGCCTGATGGAAATGGTCTAATGATTGTATCCTACAAGTCTTTAACATTTGTTCAGGCTGGTCAAGATCTTGAAGAAAATATG
GATGAAGACATATCAGAGAAAATCAAAGAACCTCTGTATTACTGGCAACAGACTGAAGATGATTTGACAGTAACCATACGGCTTCCAGAA
GACAGTACTAAGGAGGACATTCAAATACAGTTTTTGCCTGATCACATCAACATTGTACTGAAGGATCACCAGTTTTTAGAAGGAAAACTC
TATTCATCTATTGATCATGAAAGCAGTACATGGATAATTAAAGAGAGTAATAGCTTGGAGATTTCCTTGATTAAGAAGAATGAAGGACTG
ACCTGGCCAGAGCTAGTAATTGGAGATAAACAAGGGGAACTTATAAGAGATTCAGCCCAGTGTGCTGCAATAGCTGAACGTTTGATGCAT
TTGACCTCTGAAGAACTGAATCCAAATCCAGATAAAGAAAAACCACCTTGCAATGCTCAAGAGTTAGAAGAATGTGATATTTTCTTTGAA
GAGAGCTCCAGTTTATGCAGATTTGATGGCAATACATTAAAAACTACTCATGTGATAACAATCAACAGAGACAGTGGTGAAGATGTAAGC
TCCCCCAAACACGGGAAGGAGGACCCAGACAACATGCCTCACGTGGGCGGCAACACTTGGGCTGGCGGAACAGGGGGAAGAGACACGGCA
GGCCTGGGTGGCAAAGGAGGCCCTTACCGGCTGGATGCAGGCCATACGGTGTACCAGGTCTCTCAGGCTGAGAAAGATGCAGTTCCCGAA
GAGGTCAAGAGAGCTGCTAGAGAGATGGGCCAGAGAGCATTCCAGCAGAGGCTAAAGGAGATCCAAATGAGTGAATACGATGCTGCAACC
TATGAAAGGTTTTCAGGTGCTGTTCGGCGACAGGTGCACTCCCTCCGAATCATCCTGGATAATTTACAGGCTAAAGGTAAAGAAAGACAA
TGGCTAAGACATCAAGCTACTGGAGAATTAGATGATGCCAAGATCATTGATGGGCTGACTGGAGAAAAAGCCATCTACAAACGTCGGGGT
GAGCTGGAGCCACAACTTGGCAGCCCACAACAGAAACCCAAGCGTCTGCGCCTGGTGGTAGATGTGTCTGGTAGCATGTACCGTTTCAAC
AGGATGGATGGCCGGCTTGAGCGCACAATGGAGGCTGTGTGTATGGTCATGGAAGCCTTCGAGAACTATGAGGAGAAGTTCCAGTATGAC
ATCGTTGGACACTCTGGAGATGGCTACAACATTGGTCTGGTTCCAATGAACAAAATCCCCAAGGACAATAAGCAAAGACTAGAAATTCTG
AAGACAATGCATGCCCACTCTCAGTTCTGCATGAGTGGGGACCACACGTTAGAAGGGACAGAACATGCCATCAAGGAAATTGTCAAAGAA
GAAGCTGATGAGTACTTTGTCATAGTCTTGAGTGATGCAAATCTGTCACGATATGGAATACATCCTGCTAAGTTTGCTCAAATCCTCACA
AGAGACCCTCAAGTAAATGCTTTTGCCATTTTTATTGGCTCTTTAGGTGATCAAGCAACCAGGCTTCAGAGAACTTTACCAGCTGGTCGG
TCTTTCGTTGCCATGGATACCAAGGATATCCCTCAGATTTTACAACAGATCTTCACCTCCACCATGTTGTCGAGTGTCTAAGAAGTGCCC
TTCATCACCCTGATGACACCAGGATTTGAAATAAGACAGGAATAAAGAGTATTCTGAAAAAAAGAAGATATGGATGAAGTGAACCCATGC
AGTGACTGGATGATTCCGGCATTCCTGGGTCTTCCTACACTTGCTCCGTAATGAGAATTCAGAGAAGCAGCCAGAAGGAGACTTAAACAT
GGAAAGATACTCCACTGATGAGTTTAGAAGTGATTAGGGCAAGCTAGTTGACCTGCACTTTATCAAAGGTTGGGGTTAAAGGAAGGTGGT
TTTGAGAACTATGTGTTTGGTCTATTTCCAAAAACCTGAGGGGGAGAAAATACTTTGCTTTTGCCTTAACACATCATCTGGTCACGTTAG
AAAAGTGACCCCATCAAACTGAGCCTTTGATGTCACATTCTGACACAAGATGCAAGTCTGTGCAAAACCCACCAAAATGCTCCTATCCAA
CAATTATTTTTATTTTCTCCCTGCTCTGTATTGACCAGAAAACAATGATTTTATAATATTTAACCCACCAAAAAGTCCCTCCAACAGCAA
TATCTTATGAAAGTCTGGCTGTTCTCAATAATTTCATTTTCTTGGCCAAAGCCAAAAGGAATCAAAAAATCCTTGGAGTGCTTGCCTTTC
CACGTGACTTTTAAAAGGCTCTTAAAGAGCAAATGTCCTCTTCTCCTTGCTGCTAGAGTGGGAGGAGAAAGATGTCTTGCCTTAAAAGTT
TACTGTTTCTTCTGTTCTTCTAGCATCTCTCAAAAAATTCACAGTACTCCATTTTGGGGTCCAAACTGTAATGCTCAAAATAATAAATGC
TTACACGAAAATTATTTATTGAGAATATTCATATAAAAATTACCTAAAGCAAAGTAAAAAAAGTAAAATCAAGGTGGTATATTTGAAGTG
AATGGTGATTGGAAATTTTTAGCTGTAACAAAAAGAAAGAAAACAACTTTTTTTAAAGCCTCATTCTCTTTTCTTTCAAAATGTACCTTA
TTCCCACACACTCTTGGGCTGACCTTTATTTTATCAATAAGCTCAATATTACTTTGTTTAAAATAAGATGCTTCAGCAAAAGTCATTCTC
TCTTTAACCATATAATTTAAAAACTCCTCTTCACGATTGATAGCAAAATCAGAAACGTTAGGGCACCAGTGAGTTGAAAAAACTGGTCTT
AAGTTGGAAAAACTATTATTAATAATATTATCCTATCCATCCATATCTATTGAAATTGTACAGGTCCATAATTTCATTTTAATTAATTAT
AGGAAAGAAGAAAAGATAATACCCATTTGTTCTATCACCCCTCTCCCTATCATTAACTATCAAATAAATAAATAAAAGCAATCTGATTTC

>60803_60803_1_NUDCD1-VWA8_NUDCD1_chr8_110283234_ENST00000239690_VWA8_chr13_42189220_ENST00000379310_length(amino acids)=807AA_BP=439
MRPWKAMEVAANCSLRVKRPLLDPRFEGYKLSLEPLPCYQLELDAAVAEVKLRDDQYTLEHMHAFGMYNYLHCDSWYQDSVYYIDTLGRI
MNLTVMLDTALGKPREVFRLPTDLTACDNRLCASIHFSSSTWVTLSDGTGRLYVIGTGERGNSASEKWEIMFNEELGDPFIIIHSISLLN
AEEHSIATLLLRIEKEELDMKGSGFYVSLEWVTISKKNQDNKKYEIIKRDILRGKSVPHYAAIEPDGNGLMIVSYKSLTFVQAGQDLEEN
MDEDISEKIKEPLYYWQQTEDDLTVTIRLPEDSTKEDIQIQFLPDHINIVLKDHQFLEGKLYSSIDHESSTWIIKESNSLEISLIKKNEG
LTWPELVIGDKQGELIRDSAQCAAIAERLMHLTSEELNPNPDKEKPPCNAQELEECDIFFEESSSLCRFDGNTLKTTHVITINRDSGEDV
SSPKHGKEDPDNMPHVGGNTWAGGTGGRDTAGLGGKGGPYRLDAGHTVYQVSQAEKDAVPEEVKRAAREMGQRAFQQRLKEIQMSEYDAA
TYERFSGAVRRQVHSLRIILDNLQAKGKERQWLRHQATGELDDAKIIDGLTGEKAIYKRRGELEPQLGSPQQKPKRLRLVVDVSGSMYRF
NRMDGRLERTMEAVCMVMEAFENYEEKFQYDIVGHSGDGYNIGLVPMNKIPKDNKQRLEILKTMHAHSQFCMSGDHTLEGTEHAIKEIVK

--------------------------------------------------------------
>60803_60803_2_NUDCD1-VWA8_NUDCD1_chr8_110283234_ENST00000427660_VWA8_chr13_42189220_ENST00000379310_length(transcript)=3778nt_BP=1311nt
AGTACTTCATAGACTTTATCATACTTCGTAGCATCCAGTATGTTTTCTTTGCTAAGATTATTGATTTTGTATTGAAGGGTCCCATGTCCA
TCGTTTTCAATGCTTTATCTCCAGGGTTGGAGCATGCCTGCTGTGGCAGAGGTAAAACTTCGAGATGATCAATATACACTGGAACACATG
CATGCTTTTGGAATGTATAATTACCTGCACTGTGATTCATGGTATCAAGACAGTGTCTACTATATTGATACCCTTGGAAGAATTATGAAT
TTAACAGTAATGCTGGACACTGCCTTAGGAAAACCACGAGAGGTGTTTCGACTTCCTACAGATTTGACAGCATGTGACAACCGTCTTTGT
GCATCTATCCATTTCTCATCTTCTACCTGGGTTACCTTGTCAGATGGAACTGGAAGATTGTATGTCATTGGAACAGGTGAACGTGGAAAT
AGCGCTTCTGAAAAATGGGAGATTATGTTTAATGAAGAACTTGGGGATCCTTTTATTATAATTCACAGTATCTCACTGCTAAATGCTGAA
GAACATTCTATAGCTACCCTACTTCTTCGAATAGAGAAAGAGGAATTGGATATGAAAGGAAGTGGTTTCTATGTTTCTCTGGAGTGGGTC
ACTATCAGTAAGAAAAATCAAGATAATAAAAAATATGAAATTATTAAGCGTGATATTCTCCGTGGAAAGTCAGTGCCACATTATGCTGCT
ATTGAGCCTGATGGAAATGGTCTAATGATTGTATCCTACAAGTCTTTAACATTTGTTCAGGCTGGTCAAGATCTTGAAGAAAATATGGAT
GAAGACATATCAGAGAAAATCAAAGAACCTCTGTATTACTGGCAACAGACTGAAGATGATTTGACAGTAACCATACGGCTTCCAGAAGAC
AGTACTAAGGAGGACATTCAAATACAGTTTTTGCCTGATCACATCAACATTGTACTGAAGGATCACCAGTTTTTAGAAGGAAAACTCTAT
TCATCTATTGATCATGAAAGCAGTACATGGATAATTAAAGAGAGTAATAGCTTGGAGATTTCCTTGATTAAGAAGAATGAAGGACTGACC
TGGCCAGAGCTAGTAATTGGAGATAAACAAGGGGAACTTATAAGAGATTCAGCCCAGTGTGCTGCAATAGCTGAACGTTTGATGCATTTG
ACCTCTGAAGAACTGAATCCAAATCCAGATAAAGAAAAACCACCTTGCAATGCTCAAGAGTTAGAAGAATGTGATATTTTCTTTGAAGAG
AGCTCCAGTTTATGCAGATTTGATGGCAATACATTAAAAACTACTCATGTGATAACAATCAACAGAGACAGTGGTGAAGATGTAAGCTCC
CCCAAACACGGGAAGGAGGACCCAGACAACATGCCTCACGTGGGCGGCAACACTTGGGCTGGCGGAACAGGGGGAAGAGACACGGCAGGC
CTGGGTGGCAAAGGAGGCCCTTACCGGCTGGATGCAGGCCATACGGTGTACCAGGTCTCTCAGGCTGAGAAAGATGCAGTTCCCGAAGAG
GTCAAGAGAGCTGCTAGAGAGATGGGCCAGAGAGCATTCCAGCAGAGGCTAAAGGAGATCCAAATGAGTGAATACGATGCTGCAACCTAT
GAAAGGTTTTCAGGTGCTGTTCGGCGACAGGTGCACTCCCTCCGAATCATCCTGGATAATTTACAGGCTAAAGGTAAAGAAAGACAATGG
CTAAGACATCAAGCTACTGGAGAATTAGATGATGCCAAGATCATTGATGGGCTGACTGGAGAAAAAGCCATCTACAAACGTCGGGGTGAG
CTGGAGCCACAACTTGGCAGCCCACAACAGAAACCCAAGCGTCTGCGCCTGGTGGTAGATGTGTCTGGTAGCATGTACCGTTTCAACAGG
ATGGATGGCCGGCTTGAGCGCACAATGGAGGCTGTGTGTATGGTCATGGAAGCCTTCGAGAACTATGAGGAGAAGTTCCAGTATGACATC
GTTGGACACTCTGGAGATGGCTACAACATTGGTCTGGTTCCAATGAACAAAATCCCCAAGGACAATAAGCAAAGACTAGAAATTCTGAAG
ACAATGCATGCCCACTCTCAGTTCTGCATGAGTGGGGACCACACGTTAGAAGGGACAGAACATGCCATCAAGGAAATTGTCAAAGAAGAA
GCTGATGAGTACTTTGTCATAGTCTTGAGTGATGCAAATCTGTCACGATATGGAATACATCCTGCTAAGTTTGCTCAAATCCTCACAAGA
GACCCTCAAGTAAATGCTTTTGCCATTTTTATTGGCTCTTTAGGTGATCAAGCAACCAGGCTTCAGAGAACTTTACCAGCTGGTCGGTCT
TTCGTTGCCATGGATACCAAGGATATCCCTCAGATTTTACAACAGATCTTCACCTCCACCATGTTGTCGAGTGTCTAAGAAGTGCCCTTC
ATCACCCTGATGACACCAGGATTTGAAATAAGACAGGAATAAAGAGTATTCTGAAAAAAAGAAGATATGGATGAAGTGAACCCATGCAGT
GACTGGATGATTCCGGCATTCCTGGGTCTTCCTACACTTGCTCCGTAATGAGAATTCAGAGAAGCAGCCAGAAGGAGACTTAAACATGGA
AAGATACTCCACTGATGAGTTTAGAAGTGATTAGGGCAAGCTAGTTGACCTGCACTTTATCAAAGGTTGGGGTTAAAGGAAGGTGGTTTT
GAGAACTATGTGTTTGGTCTATTTCCAAAAACCTGAGGGGGAGAAAATACTTTGCTTTTGCCTTAACACATCATCTGGTCACGTTAGAAA
AGTGACCCCATCAAACTGAGCCTTTGATGTCACATTCTGACACAAGATGCAAGTCTGTGCAAAACCCACCAAAATGCTCCTATCCAACAA
TTATTTTTATTTTCTCCCTGCTCTGTATTGACCAGAAAACAATGATTTTATAATATTTAACCCACCAAAAAGTCCCTCCAACAGCAATAT
CTTATGAAAGTCTGGCTGTTCTCAATAATTTCATTTTCTTGGCCAAAGCCAAAAGGAATCAAAAAATCCTTGGAGTGCTTGCCTTTCCAC
GTGACTTTTAAAAGGCTCTTAAAGAGCAAATGTCCTCTTCTCCTTGCTGCTAGAGTGGGAGGAGAAAGATGTCTTGCCTTAAAAGTTTAC
TGTTTCTTCTGTTCTTCTAGCATCTCTCAAAAAATTCACAGTACTCCATTTTGGGGTCCAAACTGTAATGCTCAAAATAATAAATGCTTA
CACGAAAATTATTTATTGAGAATATTCATATAAAAATTACCTAAAGCAAAGTAAAAAAAGTAAAATCAAGGTGGTATATTTGAAGTGAAT
GGTGATTGGAAATTTTTAGCTGTAACAAAAAGAAAGAAAACAACTTTTTTTAAAGCCTCATTCTCTTTTCTTTCAAAATGTACCTTATTC
CCACACACTCTTGGGCTGACCTTTATTTTATCAATAAGCTCAATATTACTTTGTTTAAAATAAGATGCTTCAGCAAAAGTCATTCTCTCT
TTAACCATATAATTTAAAAACTCCTCTTCACGATTGATAGCAAAATCAGAAACGTTAGGGCACCAGTGAGTTGAAAAAACTGGTCTTAAG
TTGGAAAAACTATTATTAATAATATTATCCTATCCATCCATATCTATTGAAATTGTACAGGTCCATAATTTCATTTTAATTAATTATAGG

>60803_60803_2_NUDCD1-VWA8_NUDCD1_chr8_110283234_ENST00000427660_VWA8_chr13_42189220_ENST00000379310_length(amino acids)=772AA_BP=404
MLYLQGWSMPAVAEVKLRDDQYTLEHMHAFGMYNYLHCDSWYQDSVYYIDTLGRIMNLTVMLDTALGKPREVFRLPTDLTACDNRLCASI
HFSSSTWVTLSDGTGRLYVIGTGERGNSASEKWEIMFNEELGDPFIIIHSISLLNAEEHSIATLLLRIEKEELDMKGSGFYVSLEWVTIS
KKNQDNKKYEIIKRDILRGKSVPHYAAIEPDGNGLMIVSYKSLTFVQAGQDLEENMDEDISEKIKEPLYYWQQTEDDLTVTIRLPEDSTK
EDIQIQFLPDHINIVLKDHQFLEGKLYSSIDHESSTWIIKESNSLEISLIKKNEGLTWPELVIGDKQGELIRDSAQCAAIAERLMHLTSE
ELNPNPDKEKPPCNAQELEECDIFFEESSSLCRFDGNTLKTTHVITINRDSGEDVSSPKHGKEDPDNMPHVGGNTWAGGTGGRDTAGLGG
KGGPYRLDAGHTVYQVSQAEKDAVPEEVKRAAREMGQRAFQQRLKEIQMSEYDAATYERFSGAVRRQVHSLRIILDNLQAKGKERQWLRH
QATGELDDAKIIDGLTGEKAIYKRRGELEPQLGSPQQKPKRLRLVVDVSGSMYRFNRMDGRLERTMEAVCMVMEAFENYEEKFQYDIVGH
SGDGYNIGLVPMNKIPKDNKQRLEILKTMHAHSQFCMSGDHTLEGTEHAIKEIVKEEADEYFVIVLSDANLSRYGIHPAKFAQILTRDPQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NUDCD1-VWA8

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	VWA8	chr8:110283234	chr13:42189220	ENST00000281496		0	26	1_261	0	1040.0	PEX7

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	VWA8	chr8:110283234	chr13:42189220	ENST00000379310		36	45	1_261	1537.0	1906.0	PEX7

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for NUDCD1-VWA8

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for NUDCD1-VWA8

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source