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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NUF2-TIMM17A (FusionGDB2 ID:60877)

Fusion Gene Summary for NUF2-TIMM17A

Fusion gene summary

Fusion gene information	Fusion gene name: NUF2-TIMM17A
	Fusion gene ID: 60877
		Hgene	Tgene
	Gene symbol	NUF2	TIMM17A
	Gene ID	83540	10440
	Gene name	NUF2 component of NDC80 kinetochore complex	translocase of inner mitochondrial membrane 17A
	Synonyms	CDCA1\|CT106\|NUF2R	TIM17\|TIM17A
	Cytomap	1q23.3	1q32.1
	Type of gene	protein-coding	protein-coding
	Description	kinetochore protein Nuf2NDC80 kinetochore complex component NUF2NUF2, NDC80 kinetochore complex component, homologcancer/testis antigen 106cell division cycle associated 1cell division cycle-associated protein 1hNuf2hNuf2RhsNuf2	mitochondrial import inner membrane translocase subunit Tim17-Ainner membrane preprotein translocase Tim17amitochondrial inner membrane translocasepreprotein translocasetranslocase of inner mitochondrial membrane 17 homolog A
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000271452, ENST00000367900, ENST00000524800, ENST00000490881,	ENST00000482943, ENST00000367287,
Fusion gene scores	* DoF score	3 X 3 X 3=27	5 X 5 X 6=150
	# samples	4	7
	** MAII score	log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(7/150*10)=-1.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NUF2 [Title/Abstract] AND TIMM17A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NUF2(163317728)-TIMM17A(201926409), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across NUF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TIMM17A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-78-7159-01A	NUF2	chr1	163317728	-	TIMM17A	chr1	201926409	+
ChimerDB4	LUAD	TCGA-78-7159-01A	NUF2	chr1	163317728	+	TIMM17A	chr1	201926409	+

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Fusion Gene ORF analysis for NUF2-TIMM17A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000271452	ENST00000482943	NUF2	chr1	163317728	+	TIMM17A	chr1	201926409	+
5CDS-intron	ENST00000367900	ENST00000482943	NUF2	chr1	163317728	+	TIMM17A	chr1	201926409	+
5CDS-intron	ENST00000524800	ENST00000482943	NUF2	chr1	163317728	+	TIMM17A	chr1	201926409	+
In-frame	ENST00000271452	ENST00000367287	NUF2	chr1	163317728	+	TIMM17A	chr1	201926409	+
In-frame	ENST00000367900	ENST00000367287	NUF2	chr1	163317728	+	TIMM17A	chr1	201926409	+
In-frame	ENST00000524800	ENST00000367287	NUF2	chr1	163317728	+	TIMM17A	chr1	201926409	+
intron-3CDS	ENST00000490881	ENST00000367287	NUF2	chr1	163317728	+	TIMM17A	chr1	201926409	+
intron-intron	ENST00000490881	ENST00000482943	NUF2	chr1	163317728	+	TIMM17A	chr1	201926409	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000524800

NUF2

chr1

163317728

ENST00000367287

TIMM17A

chr1

201926409

2913

1316

333

1805

490

ENST00000367900

NUF2

chr1

163317728

ENST00000367287

TIMM17A

chr1

201926409

2873

1276

152

1765

537

ENST00000271452

NUF2

chr1

163317728

ENST00000367287

TIMM17A

chr1

201926409

3000

1403

279

1892

537

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000524800	ENST00000367287	NUF2	chr1	163317728	+	TIMM17A	chr1	201926409	+	0.000238148	0.9997619
ENST00000367900	ENST00000367287	NUF2	chr1	163317728	+	TIMM17A	chr1	201926409	+	0.000406476	0.99959356
ENST00000271452	ENST00000367287	NUF2	chr1	163317728	+	TIMM17A	chr1	201926409	+	0.000424141	0.9995759

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Fusion Genomic Features for NUF2-TIMM17A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
NUF2	chr1	163317728	+	TIMM17A	chr1	201926408	+	1.08E-05	0.99998915
NUF2	chr1	163317728	+	TIMM17A	chr1	201926408	+	1.08E-05	0.99998915

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NUF2-TIMM17A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:163317728/chr1:201926409)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NUF2

chr1:163317728

chr1:201926409

ENST00000271452

147_345

374

465.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

NUF2

chr1:163317728

chr1:201926409

ENST00000367900

147_345

374

465.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TIMM17A

chr1:163317728

chr1:201926409

ENST00000367287

113_133

172.0

Transmembrane

Helical

Tgene

TIMM17A

chr1:163317728

chr1:201926409

ENST00000367287

17_37

172.0

Transmembrane

Helical

Tgene

TIMM17A

chr1:163317728

chr1:201926409

ENST00000367287

63_77

172.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NUF2

chr1:163317728

chr1:201926409

ENST00000271452

389_459

374

465.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

NUF2

chr1:163317728

chr1:201926409

ENST00000367900

389_459

374

465.0

Coiled coil

Ontology_term=ECO:0000255

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Fusion Gene Sequence for NUF2-TIMM17A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>60877_60877_1_NUF2-TIMM17A_NUF2_chr1_163317728_ENST00000271452_TIMM17A_chr1_201926409_ENST00000367287_length(transcript)=3000nt_BP=1403nt
AGTAGGAGGCGGCAAGTTTGAAAAGTGATGACGGTTGACGTTTGCTGATTTTTGACTTTGCTTGTAGCTGCTCCCCGAACTCGCCGTCTT
CCTGTCGGCGGCCGGCACTGTAGGTGAGCGCGAGAGGACGGAGGAAGGAAGCCTGCAGACAGACGCCTTCTCCATCCCAAGGCGCGGGCA
GGTGCCGGGACGCTGGGCCTGGCGGTGTTTTCGTCGTGCTCAGCGGTGGGAGGAGGCGGAAGAAACCAGAGCCTGGGAGATTAACAGGAA
ACTTCCAAGATGGAAACTTTGTCTTTCCCCAGATATAATGTAGCTGAGATTGTGATTCATATTCGCAATAAGATCTTAACAGGAGCTGAT
GGTAAAAACCTCACCAAGAATGATCTTTATCCAAATCCAAAGCCTGAAGTCTTGCACATGATCTACATGAGAGCCTTACAAATAGTATAT
GGAATTCGACTGGAACATTTTTACATGATGCCAGTGAACTCTGAAGTCATGTATCCACATTTAATGGAAGGCTTCTTACCATTCAGCAAT
TTAGTTACTCATCTGGACTCATTTTTGCCTATCTGCCGGGTGAATGACTTTGAGACTGCTGATATTCTATGTCCAAAAGCAAAACGGACA
AGTCGGTTTTTAAGTGGCATTATCAACTTTATTCACTTCAGAGAAGCATGCCGTGAAACGTATATGGAATTTCTTTGGCAATATAAATCC
TCTGCGGACAAAATGCAACAGTTAAACGCCGCACACCAGGAGGCATTAATGAAACTGGAGAGACTTGATTCTGTTCCAGTTGAAGAGCAA
GAAGAGTTCAAGCAGCTTTCAGATGGAATTCAGGAGCTACAACAATCACTAAATCAGGATTTTCATCAAAAAACGATAGTGCTGCAAGAG
GGAAATTCCCAAAAGAAGTCAAATATTTCAGAGAAAACCAAGCGTTTGAATGAACTAAAATTGTCGGTGGTTTCTTTGAAAGAAATACAA
GAGAGTTTGAAAACAAAAATTGTGGATTCTCCAGAGAAGTTAAAGAATTATAAAGAAAAAATGAAAGATACGGTCCAGAAGCTTAAAAAT
GCCAGACAAGAAGTGGTGGAGAAATATGAAATCTATGGAGACTCAGTTGACTGCCTGCCTTCATGTCAGTTGGAAGTGCAGTTATATCAA
AAGAAAATACAGGACCTTTCAGATAATAGGGAAAAATTAGCCAGTATCTTAAAGGAGAGCCTGAACTTGGAGGACCAAATTGAGAGTGAT
GAGTCAGAACTGAAGAAATTGAAGACTGAAGAAAATTCGTTCAAAAGACTGATGATTGTGAAGAAGGAAAAACTTGCCACAGCACAATTC
AAAATAAATAAGAAGCATGAAGATGTTAAGCAATACAAACGCACAGTAATTGACCCATGGCGAATTGTGGATGACTGTGGTGGGGCCTTT
ACGATGGGTACCATTGGTGGTGGTATCTTTCAAGCAATCAAAGGTTTTCGCAATTCTCCAGTGGGAGTAAACCACAGACTACGAGGGAGT
TTGACAGCTATTAAAACCAGGGCTCCACAGTTAGGAGGTAGCTTTGCAGTTTGGGGAGGGCTGTTTTCCATGATTGACTGTAGTATGGTT
CAAGTCAGAGGAAAGGAAGATCCCTGGAACTCCATCACAAGTGGTGCCTTAACGGGAGCCATACTGGCAGCAAGAAATGGACCAGTGGCC
ATGGTTGGGTCAGCCGCAATGGGTGGCATTCTCCTAGCTTTAATTGAAGGAGCTGGTATCTTGTTGACAAGATTTGCCTCTGCACAGTTT
CCCAATGGTCCTCAGTTTGCAGAAGACCCCTCCCAGTTGCCTTCAACTCAGTTACCTTCCTCACCTTTTGGAGACTATCGACAATATCAG
TAGGACTTCTTTCCTAGGATTTCTTTAACAGAACGAGTTGTGGTTCGAGAAGGATTTCAGAAGATCAAGTTACAGTCTGTTTTTAAAACC
ATAGGTGGGACAGCTATGGCCAATAGGCTATAAAGAGACATTTAGCACTTTTTTCTATTTAAAGGAACAAGCGGGGAAGGGTGCTAAAAG
ATAATACGTTTATTTATTCACACTTGAATTGCATTTGTGATCAAAATAAATGTTTAAATCGCTAAAGGAAAATACAGTAAGTGCTTGAAA
GATGAAGGACCAAAAGGCCAAAAAACAGTGAAATATGATCATCATCTCCTTGCGGACTTCTCTGCCTGGTTTTGTGTGTTCTGTTATTCA
AACAATAAAAAGCTGGTGGAACTTACTCTTTCTTTTAAGATAAGTTGTAGACTTCGATGTTTCATGCTCATGTACTTCAAATAATGCATG
TTTTATAGTTAGTCCCTCATCACTTGAAGTGACTTCTGAGAATTATGCAGAGTCAACATGGATCATTTCACAGTGAGATGCTTTATGGAT
TGAAGGATATGGTAAAATGTTTATAGTTTACTTTGAAAGTAAAATATACTATGTCTTGGTTTTGAGGATATTGGATACAAAACTCTCTTC
CTTTAGGGCTACTGAGTCTTGATTCCTGATCATCAGAAATTTCACCAGAAACAACTTGCTTCCAATATACCCAATTCTATATGAAGAATT
CATGGAGAGTGTACTGGCACTGGAAGAGTTTAGTGTTTCTTGTATGCTTGAAAATAAAGTATGTACTGTTTTGAATGTGTTCCAAGTCCT
CTGCATAAACGATGTATTTTGGGGTCTGGTTGGGCCTGGAAAATGGATGAGCACTTCAGAACAGGTCATTTTCCTGATATTGGAAGTGAC
ATGTGGCCCTATAGGAGGCATGATGTTAGTTAATTACACATTTGCCTACATCTGTGGGAAATGGAGAACAAAGCCATGTGGGTACTGTAA
ACACACGTTTATCTTTTGGCCCAATGCCATACATATGGTAGGCATTTAATTACTGATTGTGTTTGGATAATTTGGGAATTTTCGACTGTG

>60877_60877_1_NUF2-TIMM17A_NUF2_chr1_163317728_ENST00000271452_TIMM17A_chr1_201926409_ENST00000367287_length(amino acids)=537AA_BP=375
METLSFPRYNVAEIVIHIRNKILTGADGKNLTKNDLYPNPKPEVLHMIYMRALQIVYGIRLEHFYMMPVNSEVMYPHLMEGFLPFSNLVT
HLDSFLPICRVNDFETADILCPKAKRTSRFLSGIINFIHFREACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEF
KQLSDGIQELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQ
EVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKIN
KKHEDVKQYKRTVIDPWRIVDDCGGAFTMGTIGGGIFQAIKGFRNSPVGVNHRLRGSLTAIKTRAPQLGGSFAVWGGLFSMIDCSMVQVR

--------------------------------------------------------------
>60877_60877_2_NUF2-TIMM17A_NUF2_chr1_163317728_ENST00000367900_TIMM17A_chr1_201926409_ENST00000367287_length(transcript)=2873nt_BP=1276nt
GGAATGGGGCGGGACTTCCAGTAGGAGGCGGCAAGTTTGAAAAGTGATGACGGTTGACGTTTGCTGATTTTTGACTTTGCTTGTAGCTGC
TCCCCGAACTCGCCGTCTTCCTGTCGGCGGCCGGCACTGTAGATTAACAGGAAACTTCCAAGATGGAAACTTTGTCTTTCCCCAGATATA
ATGTAGCTGAGATTGTGATTCATATTCGCAATAAGATCTTAACAGGAGCTGATGGTAAAAACCTCACCAAGAATGATCTTTATCCAAATC
CAAAGCCTGAAGTCTTGCACATGATCTACATGAGAGCCTTACAAATAGTATATGGAATTCGACTGGAACATTTTTACATGATGCCAGTGA
ACTCTGAAGTCATGTATCCACATTTAATGGAAGGCTTCTTACCATTCAGCAATTTAGTTACTCATCTGGACTCATTTTTGCCTATCTGCC
GGGTGAATGACTTTGAGACTGCTGATATTCTATGTCCAAAAGCAAAACGGACAAGTCGGTTTTTAAGTGGCATTATCAACTTTATTCACT
TCAGAGAAGCATGCCGTGAAACGTATATGGAATTTCTTTGGCAATATAAATCCTCTGCGGACAAAATGCAACAGTTAAACGCCGCACACC
AGGAGGCATTAATGAAACTGGAGAGACTTGATTCTGTTCCAGTTGAAGAGCAAGAAGAGTTCAAGCAGCTTTCAGATGGAATTCAGGAGC
TACAACAATCACTAAATCAGGATTTTCATCAAAAAACGATAGTGCTGCAAGAGGGAAATTCCCAAAAGAAGTCAAATATTTCAGAGAAAA
CCAAGCGTTTGAATGAACTAAAATTGTCGGTGGTTTCTTTGAAAGAAATACAAGAGAGTTTGAAAACAAAAATTGTGGATTCTCCAGAGA
AGTTAAAGAATTATAAAGAAAAAATGAAAGATACGGTCCAGAAGCTTAAAAATGCCAGACAAGAAGTGGTGGAGAAATATGAAATCTATG
GAGACTCAGTTGACTGCCTGCCTTCATGTCAGTTGGAAGTGCAGTTATATCAAAAGAAAATACAGGACCTTTCAGATAATAGGGAAAAAT
TAGCCAGTATCTTAAAGGAGAGCCTGAACTTGGAGGACCAAATTGAGAGTGATGAGTCAGAACTGAAGAAATTGAAGACTGAAGAAAATT
CGTTCAAAAGACTGATGATTGTGAAGAAGGAAAAACTTGCCACAGCACAATTCAAAATAAATAAGAAGCATGAAGATGTTAAGCAATACA
AACGCACAGTAATTGACCCATGGCGAATTGTGGATGACTGTGGTGGGGCCTTTACGATGGGTACCATTGGTGGTGGTATCTTTCAAGCAA
TCAAAGGTTTTCGCAATTCTCCAGTGGGAGTAAACCACAGACTACGAGGGAGTTTGACAGCTATTAAAACCAGGGCTCCACAGTTAGGAG
GTAGCTTTGCAGTTTGGGGAGGGCTGTTTTCCATGATTGACTGTAGTATGGTTCAAGTCAGAGGAAAGGAAGATCCCTGGAACTCCATCA
CAAGTGGTGCCTTAACGGGAGCCATACTGGCAGCAAGAAATGGACCAGTGGCCATGGTTGGGTCAGCCGCAATGGGTGGCATTCTCCTAG
CTTTAATTGAAGGAGCTGGTATCTTGTTGACAAGATTTGCCTCTGCACAGTTTCCCAATGGTCCTCAGTTTGCAGAAGACCCCTCCCAGT
TGCCTTCAACTCAGTTACCTTCCTCACCTTTTGGAGACTATCGACAATATCAGTAGGACTTCTTTCCTAGGATTTCTTTAACAGAACGAG
TTGTGGTTCGAGAAGGATTTCAGAAGATCAAGTTACAGTCTGTTTTTAAAACCATAGGTGGGACAGCTATGGCCAATAGGCTATAAAGAG
ACATTTAGCACTTTTTTCTATTTAAAGGAACAAGCGGGGAAGGGTGCTAAAAGATAATACGTTTATTTATTCACACTTGAATTGCATTTG
TGATCAAAATAAATGTTTAAATCGCTAAAGGAAAATACAGTAAGTGCTTGAAAGATGAAGGACCAAAAGGCCAAAAAACAGTGAAATATG
ATCATCATCTCCTTGCGGACTTCTCTGCCTGGTTTTGTGTGTTCTGTTATTCAAACAATAAAAAGCTGGTGGAACTTACTCTTTCTTTTA
AGATAAGTTGTAGACTTCGATGTTTCATGCTCATGTACTTCAAATAATGCATGTTTTATAGTTAGTCCCTCATCACTTGAAGTGACTTCT
GAGAATTATGCAGAGTCAACATGGATCATTTCACAGTGAGATGCTTTATGGATTGAAGGATATGGTAAAATGTTTATAGTTTACTTTGAA
AGTAAAATATACTATGTCTTGGTTTTGAGGATATTGGATACAAAACTCTCTTCCTTTAGGGCTACTGAGTCTTGATTCCTGATCATCAGA
AATTTCACCAGAAACAACTTGCTTCCAATATACCCAATTCTATATGAAGAATTCATGGAGAGTGTACTGGCACTGGAAGAGTTTAGTGTT
TCTTGTATGCTTGAAAATAAAGTATGTACTGTTTTGAATGTGTTCCAAGTCCTCTGCATAAACGATGTATTTTGGGGTCTGGTTGGGCCT
GGAAAATGGATGAGCACTTCAGAACAGGTCATTTTCCTGATATTGGAAGTGACATGTGGCCCTATAGGAGGCATGATGTTAGTTAATTAC
ACATTTGCCTACATCTGTGGGAAATGGAGAACAAAGCCATGTGGGTACTGTAAACACACGTTTATCTTTTGGCCCAATGCCATACATATG

>60877_60877_2_NUF2-TIMM17A_NUF2_chr1_163317728_ENST00000367900_TIMM17A_chr1_201926409_ENST00000367287_length(amino acids)=537AA_BP=375
METLSFPRYNVAEIVIHIRNKILTGADGKNLTKNDLYPNPKPEVLHMIYMRALQIVYGIRLEHFYMMPVNSEVMYPHLMEGFLPFSNLVT
HLDSFLPICRVNDFETADILCPKAKRTSRFLSGIINFIHFREACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEF
KQLSDGIQELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQ
EVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKIN
KKHEDVKQYKRTVIDPWRIVDDCGGAFTMGTIGGGIFQAIKGFRNSPVGVNHRLRGSLTAIKTRAPQLGGSFAVWGGLFSMIDCSMVQVR

--------------------------------------------------------------
>60877_60877_3_NUF2-TIMM17A_NUF2_chr1_163317728_ENST00000524800_TIMM17A_chr1_201926409_ENST00000367287_length(transcript)=2913nt_BP=1316nt
AACCGGCATCCGTCGCGGTTGGACGTGGGCTTGGCGGAATGGGGCGGGACTTCCAGTAGGAGGCGGCAAGTTTGAAAAGTGATGACGGTT
GACGTTTGCTGATTTTTGACTTTGCTTGTAGCTGCTCCCCGAACTCGCCGTCTTCCTGTCGGCGGCCGGCACTGTAGGTGAGCGCGAGAG
GACGGAGGAAGGAAGCCTGCAGACAGACGCCTTCTCCATCCCAAGGCGCGGGCAGGTGCCGGGACGCTGGGCCTGGCGGTGTTTTCGTCG
TGCTCAGCGGTGGGAGGAGGCGGAAGAAACCAGAGCCTGGGAGATTAACAGGAAACTTCCAAGATGGAAACTTTGTCTTTCCCCAGATAT
AATGTAGCTGAGATTGTGATTCATATTCGCAATAAGATCTTAACAGGAGCTGATGGTAAAAACCTCACCAAGAATGATCTTTATCCAAAT
CCAAAGCCTGAAGTCTTGCACATGATCTACATGAGAGCCTTACAAATAGTATATGGAATTCGACTGGAACATTTTTACATGATGCCAGTG
AACTCTGAAGTCATGTATCCACATTTAATGGAAGGCTTCTTACCATTCAGCAATTTAGTTACTCATCTGGACTCATTTTTGCCTATCTGC
CGGGTGAATGACTTTGAGACTGCTGATATTCTATGTCCAAAAGCAAAACGGACAAGTCGGTTTTTAAGTGGCATTATCAACTTTATTCAC
TTCAGAGAAGCATGCCGTGAAACGTATATGGAATTTCTTTGGCAATATAAATCCTCTGCGGACAAAATGCAACAGTTAAACGCCGCACAC
CAGGAGGCATTAATGAAACTGGAGAGACTTGATTCTGTTCCAGTTGAAGAGCAAGAAGAGTTCAAGCAGCTTTCAGATGGAATTCAGGAG
CTACAACAATCACTAAATCAGGATTTTCATCAAAAAACGATAGTGCTGCAAGAGGGAAATTCCCAAAAGAAGTCAAATATTTCAGAGAAA
ACCAAGCGTTTGAATGAACTAAAATTGTCGGTGGTTTCTTTGAAAGAAATACAAGAGAGTTTGAAAACAAAAATTGTGGATTCTCCAGAG
AAGTTAAAGAATTATAAAGAAAAAATGAAAGATACGGTCCAGAAGCTTAAAAATGCCAGAAGCCTGAACTTGGAGGACCAAATTGAGAGT
GATGAGTCAGAACTGAAGAAATTGAAGACTGAAGAAAATTCGTTCAAAAGACTGATGATTGTGAAGAAGGAAAAACTTGCCACAGCACAA
TTCAAAATAAATAAGAAGCATGAAGATGTTAAGCAATACAAACGCACAGTAATTGACCCATGGCGAATTGTGGATGACTGTGGTGGGGCC
TTTACGATGGGTACCATTGGTGGTGGTATCTTTCAAGCAATCAAAGGTTTTCGCAATTCTCCAGTGGGAGTAAACCACAGACTACGAGGG
AGTTTGACAGCTATTAAAACCAGGGCTCCACAGTTAGGAGGTAGCTTTGCAGTTTGGGGAGGGCTGTTTTCCATGATTGACTGTAGTATG
GTTCAAGTCAGAGGAAAGGAAGATCCCTGGAACTCCATCACAAGTGGTGCCTTAACGGGAGCCATACTGGCAGCAAGAAATGGACCAGTG
GCCATGGTTGGGTCAGCCGCAATGGGTGGCATTCTCCTAGCTTTAATTGAAGGAGCTGGTATCTTGTTGACAAGATTTGCCTCTGCACAG
TTTCCCAATGGTCCTCAGTTTGCAGAAGACCCCTCCCAGTTGCCTTCAACTCAGTTACCTTCCTCACCTTTTGGAGACTATCGACAATAT
CAGTAGGACTTCTTTCCTAGGATTTCTTTAACAGAACGAGTTGTGGTTCGAGAAGGATTTCAGAAGATCAAGTTACAGTCTGTTTTTAAA
ACCATAGGTGGGACAGCTATGGCCAATAGGCTATAAAGAGACATTTAGCACTTTTTTCTATTTAAAGGAACAAGCGGGGAAGGGTGCTAA
AAGATAATACGTTTATTTATTCACACTTGAATTGCATTTGTGATCAAAATAAATGTTTAAATCGCTAAAGGAAAATACAGTAAGTGCTTG
AAAGATGAAGGACCAAAAGGCCAAAAAACAGTGAAATATGATCATCATCTCCTTGCGGACTTCTCTGCCTGGTTTTGTGTGTTCTGTTAT
TCAAACAATAAAAAGCTGGTGGAACTTACTCTTTCTTTTAAGATAAGTTGTAGACTTCGATGTTTCATGCTCATGTACTTCAAATAATGC
ATGTTTTATAGTTAGTCCCTCATCACTTGAAGTGACTTCTGAGAATTATGCAGAGTCAACATGGATCATTTCACAGTGAGATGCTTTATG
GATTGAAGGATATGGTAAAATGTTTATAGTTTACTTTGAAAGTAAAATATACTATGTCTTGGTTTTGAGGATATTGGATACAAAACTCTC
TTCCTTTAGGGCTACTGAGTCTTGATTCCTGATCATCAGAAATTTCACCAGAAACAACTTGCTTCCAATATACCCAATTCTATATGAAGA
ATTCATGGAGAGTGTACTGGCACTGGAAGAGTTTAGTGTTTCTTGTATGCTTGAAAATAAAGTATGTACTGTTTTGAATGTGTTCCAAGT
CCTCTGCATAAACGATGTATTTTGGGGTCTGGTTGGGCCTGGAAAATGGATGAGCACTTCAGAACAGGTCATTTTCCTGATATTGGAAGT
GACATGTGGCCCTATAGGAGGCATGATGTTAGTTAATTACACATTTGCCTACATCTGTGGGAAATGGAGAACAAAGCCATGTGGGTACTG
TAAACACACGTTTATCTTTTGGCCCAATGCCATACATATGGTAGGCATTTAATTACTGATTGTGTTTGGATAATTTGGGAATTTTCGACT

>60877_60877_3_NUF2-TIMM17A_NUF2_chr1_163317728_ENST00000524800_TIMM17A_chr1_201926409_ENST00000367287_length(amino acids)=490AA_BP=328
METLSFPRYNVAEIVIHIRNKILTGADGKNLTKNDLYPNPKPEVLHMIYMRALQIVYGIRLEHFYMMPVNSEVMYPHLMEGFLPFSNLVT
HLDSFLPICRVNDFETADILCPKAKRTSRFLSGIINFIHFREACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEF
KQLSDGIQELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARS
LNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIDPWRIVDDCGGAFTMGTIGGGIFQAIKGFRNSP
VGVNHRLRGSLTAIKTRAPQLGGSFAVWGGLFSMIDCSMVQVRGKEDPWNSITSGALTGAILAARNGPVAMVGSAAMGGILLALIEGAGI

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Fusion Gene PPI Analysis for NUF2-TIMM17A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	NUF2	chr1:163317728	chr1:201926409	ENST00000271452	+	12	14	386_464	374.6666666666667	465.0	the C-terminus of NDC80 and the SPBC24-SPBC25 subcomplex
Hgene	NUF2	chr1:163317728	chr1:201926409	ENST00000367900	+	12	14	386_464	374.6666666666667	465.0	the C-terminus of NDC80 and the SPBC24-SPBC25 subcomplex
Hgene	NUF2	chr1:163317728	chr1:201926409	ENST00000271452	+	12	14	1_385	374.6666666666667	465.0	the N-terminus of NDC80
Hgene	NUF2	chr1:163317728	chr1:201926409	ENST00000367900	+	12	14	1_385	374.6666666666667	465.0	the N-terminus of NDC80

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for NUF2-TIMM17A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for NUF2-TIMM17A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source