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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NUMA1-RARA (FusionGDB2 ID:60916)

Fusion Gene Summary for NUMA1-RARA

check button Fusion gene summary
Fusion gene informationFusion gene name: NUMA1-RARA
Fusion gene ID: 60916
HgeneTgene
Gene symbol

NUMA1

RARA

Gene ID

4926

5914

Gene namenuclear mitotic apparatus protein 1retinoic acid receptor alpha
SynonymsNMP-22|NUMANR1B1|RAR
Cytomap

11q13.4

17q21.2

Type of geneprotein-codingprotein-coding
Descriptionnuclear mitotic apparatus protein 1SP-H antigencentrophilin stabilizes mitotic spindle in mitotic cellsnuclear matrix protein-22structural nuclear proteinretinoic acid receptor alphaRAR-alphanuclear receptor subfamily 1 group B member 1nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long formretinoic acid nuclear receptor alpha variant 1retinoic acid nuclear receptor alpha variant 2
Modification date2020031320200327
UniProtAcc.

P10276

Ensembl transtripts involved in fusion geneENST00000351960, ENST00000358965, 
ENST00000393695, ENST00000543450, 
ENST00000254066, ENST00000394081, 
ENST00000394086, ENST00000394089, 
ENST00000420042, ENST00000425707, 
Fusion gene scores* DoF score36 X 22 X 17=1346429 X 39 X 17=19227
# samples 4355
** MAII scorelog2(43/13464*10)=-4.96862661174049
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(55/19227*10)=-5.12755824682814
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NUMA1 [Title/Abstract] AND RARA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNUMA1(71717270)-RARA(38504544), # samples:1
NUMA1(71717081)-RARA(38504544), # samples:1
Anticipated loss of major functional domain due to fusion event.NUMA1-RARA seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NUMA1-RARA seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NUMA1-RARA seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
NUMA1-RARA seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
NUMA1-RARA seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
NUMA1-RARA seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNUMA1

GO:0000132

establishment of mitotic spindle orientation

21816348

HgeneNUMA1

GO:0030953

astral microtubule organization

12445386

HgeneNUMA1

GO:0060236

regulation of mitotic spindle organization

26195665

HgeneNUMA1

GO:1902365

positive regulation of protein localization to spindle pole body

16076287

TgeneRARA

GO:0007165

signal transduction

2825025

TgeneRARA

GO:0030853

negative regulation of granulocyte differentiation

19917671

TgeneRARA

GO:0032689

negative regulation of interferon-gamma production

18416830

TgeneRARA

GO:0032720

negative regulation of tumor necrosis factor production

18416830

TgeneRARA

GO:0032736

positive regulation of interleukin-13 production

18416830

TgeneRARA

GO:0032753

positive regulation of interleukin-4 production

18416830

TgeneRARA

GO:0032754

positive regulation of interleukin-5 production

18416830

TgeneRARA

GO:0045630

positive regulation of T-helper 2 cell differentiation

18416830

TgeneRARA

GO:0045892

negative regulation of transcription, DNA-templated

20080953

TgeneRARA

GO:0045893

positive regulation of transcription, DNA-templated

18845237|19850744|20080953

TgeneRARA

GO:0045944

positive regulation of transcription by RNA polymerase II

19850744|21131358

TgeneRARA

GO:0071300

cellular response to retinoic acid

19917671

TgeneRARA

GO:0071391

cellular response to estrogen stimulus

20080953


check buttonFusion gene breakpoints across NUMA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RARA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4acute promyelocytic leukemiaAF012304NUMA1chr11

71717270

RARAchr17

38504544
ChimerKB3..NUMA1chr11

71717080

-RARAchr17

38504567

+
ChiTaRS5.0N/AAF012304NUMA1chr11

71717081

-RARAchr17

38504544

+


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Fusion Gene ORF analysis for NUMA1-RARA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000351960ENST00000254066NUMA1chr11

71717081

-RARAchr17

38504544

+
5CDS-intronENST00000351960ENST00000394081NUMA1chr11

71717080

-RARAchr17

38504567

+
5CDS-intronENST00000351960ENST00000394081NUMA1chr11

71717081

-RARAchr17

38504544

+
5CDS-intronENST00000351960ENST00000394086NUMA1chr11

71717080

-RARAchr17

38504567

+
5CDS-intronENST00000351960ENST00000394086NUMA1chr11

71717081

-RARAchr17

38504544

+
5CDS-intronENST00000351960ENST00000394089NUMA1chr11

71717081

-RARAchr17

38504544

+
5CDS-intronENST00000351960ENST00000420042NUMA1chr11

71717080

-RARAchr17

38504567

+
5CDS-intronENST00000351960ENST00000420042NUMA1chr11

71717081

-RARAchr17

38504544

+
5CDS-intronENST00000351960ENST00000425707NUMA1chr11

71717080

-RARAchr17

38504567

+
5CDS-intronENST00000351960ENST00000425707NUMA1chr11

71717081

-RARAchr17

38504544

+
5CDS-intronENST00000358965ENST00000254066NUMA1chr11

71717081

-RARAchr17

38504544

+
5CDS-intronENST00000358965ENST00000394081NUMA1chr11

71717080

-RARAchr17

38504567

+
5CDS-intronENST00000358965ENST00000394081NUMA1chr11

71717081

-RARAchr17

38504544

+
5CDS-intronENST00000358965ENST00000394086NUMA1chr11

71717080

-RARAchr17

38504567

+
5CDS-intronENST00000358965ENST00000394086NUMA1chr11

71717081

-RARAchr17

38504544

+
5CDS-intronENST00000358965ENST00000394089NUMA1chr11

71717081

-RARAchr17

38504544

+
5CDS-intronENST00000358965ENST00000420042NUMA1chr11

71717080

-RARAchr17

38504567

+
5CDS-intronENST00000358965ENST00000420042NUMA1chr11

71717081

-RARAchr17

38504544

+
5CDS-intronENST00000358965ENST00000425707NUMA1chr11

71717080

-RARAchr17

38504567

+
5CDS-intronENST00000358965ENST00000425707NUMA1chr11

71717081

-RARAchr17

38504544

+
5CDS-intronENST00000393695ENST00000254066NUMA1chr11

71717081

-RARAchr17

38504544

+
5CDS-intronENST00000393695ENST00000394081NUMA1chr11

71717080

-RARAchr17

38504567

+
5CDS-intronENST00000393695ENST00000394081NUMA1chr11

71717081

-RARAchr17

38504544

+
5CDS-intronENST00000393695ENST00000394086NUMA1chr11

71717080

-RARAchr17

38504567

+
5CDS-intronENST00000393695ENST00000394086NUMA1chr11

71717081

-RARAchr17

38504544

+
5CDS-intronENST00000393695ENST00000394089NUMA1chr11

71717081

-RARAchr17

38504544

+
5CDS-intronENST00000393695ENST00000420042NUMA1chr11

71717080

-RARAchr17

38504567

+
5CDS-intronENST00000393695ENST00000420042NUMA1chr11

71717081

-RARAchr17

38504544

+
5CDS-intronENST00000393695ENST00000425707NUMA1chr11

71717080

-RARAchr17

38504567

+
5CDS-intronENST00000393695ENST00000425707NUMA1chr11

71717081

-RARAchr17

38504544

+
Frame-shiftENST00000358965ENST00000254066NUMA1chr11

71717080

-RARAchr17

38504567

+
Frame-shiftENST00000358965ENST00000394089NUMA1chr11

71717080

-RARAchr17

38504567

+
In-frameENST00000351960ENST00000254066NUMA1chr11

71717080

-RARAchr17

38504567

+
In-frameENST00000351960ENST00000394089NUMA1chr11

71717080

-RARAchr17

38504567

+
In-frameENST00000393695ENST00000254066NUMA1chr11

71717080

-RARAchr17

38504567

+
In-frameENST00000393695ENST00000394089NUMA1chr11

71717080

-RARAchr17

38504567

+
intron-3CDSENST00000543450ENST00000254066NUMA1chr11

71717080

-RARAchr17

38504567

+
intron-3CDSENST00000543450ENST00000394089NUMA1chr11

71717080

-RARAchr17

38504567

+
intron-intronENST00000351960ENST00000254066NUMA1chr11

71717270

RARAchr17

38504544

intron-intronENST00000351960ENST00000394081NUMA1chr11

71717270

RARAchr17

38504544

intron-intronENST00000351960ENST00000394086NUMA1chr11

71717270

RARAchr17

38504544

intron-intronENST00000351960ENST00000394089NUMA1chr11

71717270

RARAchr17

38504544

intron-intronENST00000351960ENST00000420042NUMA1chr11

71717270

RARAchr17

38504544

intron-intronENST00000351960ENST00000425707NUMA1chr11

71717270

RARAchr17

38504544

intron-intronENST00000358965ENST00000254066NUMA1chr11

71717270

RARAchr17

38504544

intron-intronENST00000358965ENST00000394081NUMA1chr11

71717270

RARAchr17

38504544

intron-intronENST00000358965ENST00000394086NUMA1chr11

71717270

RARAchr17

38504544

intron-intronENST00000358965ENST00000394089NUMA1chr11

71717270

RARAchr17

38504544

intron-intronENST00000358965ENST00000420042NUMA1chr11

71717270

RARAchr17

38504544

intron-intronENST00000358965ENST00000425707NUMA1chr11

71717270

RARAchr17

38504544

intron-intronENST00000393695ENST00000254066NUMA1chr11

71717270

RARAchr17

38504544

intron-intronENST00000393695ENST00000394081NUMA1chr11

71717270

RARAchr17

38504544

intron-intronENST00000393695ENST00000394086NUMA1chr11

71717270

RARAchr17

38504544

intron-intronENST00000393695ENST00000394089NUMA1chr11

71717270

RARAchr17

38504544

intron-intronENST00000393695ENST00000420042NUMA1chr11

71717270

RARAchr17

38504544

intron-intronENST00000393695ENST00000425707NUMA1chr11

71717270

RARAchr17

38504544

intron-intronENST00000543450ENST00000254066NUMA1chr11

71717270

RARAchr17

38504544

intron-intronENST00000543450ENST00000254066NUMA1chr11

71717081

-RARAchr17

38504544

+
intron-intronENST00000543450ENST00000394081NUMA1chr11

71717270

RARAchr17

38504544

intron-intronENST00000543450ENST00000394081NUMA1chr11

71717080

-RARAchr17

38504567

+
intron-intronENST00000543450ENST00000394081NUMA1chr11

71717081

-RARAchr17

38504544

+
intron-intronENST00000543450ENST00000394086NUMA1chr11

71717270

RARAchr17

38504544

intron-intronENST00000543450ENST00000394086NUMA1chr11

71717080

-RARAchr17

38504567

+
intron-intronENST00000543450ENST00000394086NUMA1chr11

71717081

-RARAchr17

38504544

+
intron-intronENST00000543450ENST00000394089NUMA1chr11

71717270

RARAchr17

38504544

intron-intronENST00000543450ENST00000394089NUMA1chr11

71717081

-RARAchr17

38504544

+
intron-intronENST00000543450ENST00000420042NUMA1chr11

71717270

RARAchr17

38504544

intron-intronENST00000543450ENST00000420042NUMA1chr11

71717080

-RARAchr17

38504567

+
intron-intronENST00000543450ENST00000420042NUMA1chr11

71717081

-RARAchr17

38504544

+
intron-intronENST00000543450ENST00000425707NUMA1chr11

71717270

RARAchr17

38504544

intron-intronENST00000543450ENST00000425707NUMA1chr11

71717080

-RARAchr17

38504567

+
intron-intronENST00000543450ENST00000425707NUMA1chr11

71717081

-RARAchr17

38504544

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000351960NUMA1chr1171717080-ENST00000254066RARAchr1738504567+4237245615436661170
ENST00000351960NUMA1chr1171717080-ENST00000394089RARAchr1738504567+3772245615436661170
ENST00000393695NUMA1chr1171717080-ENST00000254066RARAchr1738504567+7805602431472342306
ENST00000393695NUMA1chr1171717080-ENST00000394089RARAchr1738504567+7340602431472342306

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NUMA1-RARA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NUMA1-RARA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:71717270/chr17:38504544)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.RARA

P10276

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Receptor for retinoic acid (PubMed:19850744, PubMed:16417524, PubMed:20215566). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed:28167758). The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:28167758, PubMed:19398580). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:16417524). On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation (PubMed:9267036, PubMed:19850744, PubMed:20215566). Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (PubMed:28167758). Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (PubMed:28167758). RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis (By similarity). Has a role in the survival of early spermatocytes at the beginning prophase of meiosis (By similarity). In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (PubMed:28167758). {ECO:0000250|UniProtKB:P11416, ECO:0000269|PubMed:16417524, ECO:0000269|PubMed:19398580, ECO:0000269|PubMed:19850744, ECO:0000269|PubMed:20215566, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:9267036}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NUMA1-RARA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>60916_60916_1_NUMA1-RARA_NUMA1_chr11_71717080_ENST00000351960_RARA_chr17_38504567_ENST00000254066_length(transcript)=4237nt_BP=2456nt
GTGCTGGAGAGGCCGCTGCGAGCGGAAGGCCTCCTCCATAACCGAGTCCGAAAGGGCAGAATCTATGGGGGTGGAAACTAATTCTAAGCC
AGACTGCTGGAGATCACCCTGTTCTAGTGTGTGGAGGCTTCCACCAGGAGGCGCATTGGAGTGACTGTCTGGCATCACCAAGATGACACT
CCACGCCACCCGGGGGGCTGCACTCCTCTCTTGGGTGAACAGTCTACACGTGGCTGACCCTGTGGAGGCTGTGCTGCAGCTCCAGGACTG
CAGCATCTTCATCAAGATCATTGACAGAATCCATGGCACTGAAGAGGGACAGCAAATCTTGAAGCAGCCGGTGTCAGAGAGACTGGACTT
TGTGTGCAGTTTTCTGCAGAAAAATCGAAAACATCCCTCTTCCCCAGAATGCCTGGTATCTGCACAGAAGGTGCTAGAGGGATCAGAGCT
GGAACTGGCGAAGATGACCATGCTGCTCTTATACCACTCTACCATGAGCTCCAAAAGTCCCAGGGACTGGGAACAGTTTGAATATAAAAT
TCAGGCTGAGTTGGCTGTCATTCTTAAATTTGTGCTGGACCATGAGGACGGGCTAAACCTTAATGAGGACCTAGAGAACTTCCTACAGAA
AGCTCCTGTGCCTTCTACCTGTTCTAGCACATTCCCTGAAGAGCTCTCCCCACCTAGCCACCAGGCCAAGAGGGAGATTCGCTTCCTAGA
GCTACAGAAGGTTGCCTCCTCTTCCAGTGGGAACAACTTTCTCTCAGGTTCTCCAGCTTCTCCCATGGGTGATATCCTGCAGACCCCACA
GTTCCAGATGAGACGGCTGAAGAAGCAGCTTGCTGATGAGAGAAGTAATAGGGATGAGCTGGAGCTGGAGCTAGCTGAGAACCGCAAGCT
CCTCACCGAGAAGGATGCACAGATAGCCATGATGCAGCAGCGCATTGACCGCCTAGCCCTGCTGAATGAGAAGCAGGCGGCCAGCCCACT
GGAGCCCAAGGAGCTTGAGGAGCTGCGTGACAAGAATGAGAGCCTTACCATGCGGCTGCATGAAACCCTGAAGCAGTGCCAGGACCTGAA
GACAGAGAAGAGCCAGATGGATCGCAAAATCAACCAGCTTTCGGAGGAGAATGGAGACCTTTCCTTTAAGCTGCGGGAGTTTGCCAGTCA
TCTGCAGCAGCTACAGGATGCCCTCAATGAGCTGACGGAGGAGCACAGCAAGGCCACTCAGGAGTGGCTAGAGAAGCAGGCCCAGCTGGA
GAAGGAGCTCAGCGCAGCCCTGCAGGACAAGAAATGCCTTGAAGAGAAGAACGAAATCCTTCAGGGAAAACTTTCACAGCTGGAAGAACA
CTTGTCCCAGCTGCAGGATAACCCACCCCAGGAGAAGGGCGAGGTGCTGGGTGATGTCTTGCAGGTGGAAGAACTGAGTAAGAAACTGGC
TGACTCTGACCAAGCCAGCAAGGTGCAGCAGCAGAAGCTGAAGGCTGTCCAGGCTCAGGGAGGCGAGAGCCAGCAGGAGGCCCAGCGCCT
CCAGGCCCAGCTGAATGAACTGCAAGCCCAGTTGAGCCAGAAGGAGCAGGCAGCTGAGCACTATAAGCTGCAGATGGAGAAAGCCAAAAC
ACATTATGATGCCAAGAAGCAGCAGAACCAAGAGCTGCAGGAGCAGCTGCGGAGCCTGGAGCAGCTGCAGAAGGAAAACAAAGAGCTGCG
AGCTGAAGCTGAACGGCTGGGCCATGAGCTACAGCAGGCTGGGCTGAAGACCAAGGAGGCTGAACAGACCTGCCGCCACCTTACTGCCCA
GGTGCGCAGCCTGGAGGCACAGGTTGCCCATGCAGACCAGCAGCTTCGAGACCTGGGCAAATTCCAGGTGGCAACTGATGCTTTAAAGAG
CCGTGAGCCCCAGGCTAAGCCCCAGCTGGACTTGAGTATTGACAGCCTGGATCTGAGCTGCGAGGAGGGGACCCCACTCAGTATCACCAG
CAAGCTGCCTCGTACCCAGCCAGACGGCACCAGCGTCCCTGGAGAACCAGCCTCACCTATCTCCCAGCGCCTGCCCCCCAAGGTAGAATC
CCTGGAGAGTCTCTACTTCACTCCCATCCCTGCTCGGAGTCAGGCCCCCCTGGAGAGCAGCCTGGACTCCCTGGGAGACGTCTTCCTGGA
CTCGGGTCGTAAGACCCGCTCCGCTCGTCGGCGCACCACGCAGATCATCAACATCACCATGACCAAGAAGCTAGATGTGGAAGAGCCAGA
CAGCGCCAACTCATCGTTCTACAGCACGCGGTCTGCTCCTGCTTCCCAGGCTAGCCTGCGAGCCACCTCCTCTACTCAGTCTCTAGCTCG
CCTGGGTTCTCCCGATTATGGCAACTCAGCCCTGCTCAGCTTGCCTGGCTACCGCCCCACCACTCGCAGTTCTGCTCGTCGTTCCCAGGC
CGGGGTGTCCAGTGGGGCCCCTCCAGCCATTGAGACCCAGAGCAGCAGTTCTGAAGAGATAGTGCCCAGCCCTCCCTCGCCACCCCCTCT
ACCCCGCATCTACAAGCCTTGCTTTGTCTGTCAGGACAAGTCCTCAGGCTACCACTATGGGGTCAGCGCCTGTGAGGGCTGCAAGGGCTT
CTTCCGCCGCAGCATCCAGAAGAACATGGTGTACACGTGTCACCGGGACAAGAACTGCATCATCAACAAGGTGACCCGGAACCGCTGCCA
GTACTGCCGACTGCAGAAGTGCTTTGAAGTGGGCATGTCCAAGGAGTCTGTGAGAAACGACCGAAACAAGAAGAAGAAGGAGGTGCCCAA
GCCCGAGTGCTCTGAGAGCTACACGCTGACGCCGGAGGTGGGGGAGCTCATTGAGAAGGTGCGCAAAGCGCACCAGGAAACCTTCCCTGC
CCTCTGCCAGCTGGGCAAATACACTACGAACAACAGCTCAGAACAACGTGTCTCTCTGGACATTGACCTCTGGGACAAGTTCAGTGAACT
CTCCACCAAGTGCATCATTAAGACTGTGGAGTTCGCCAAGCAGCTGCCCGGCTTCACCACCCTCACCATCGCCGACCAGATCACCCTCCT
CAAGGCTGCCTGCCTGGACATCCTGATCCTGCGGATCTGCACGCGGTACACGCCCGAGCAGGACACCATGACCTTCTCGGACGGGCTGAC
CCTGAACCGGACCCAGATGCACAACGCTGGCTTCGGCCCCCTCACCGACCTGGTCTTTGCCTTCGCCAACCAGCTGCTGCCCCTGGAGAT
GGATGATGCGGAGACGGGGCTGCTCAGCGCCATCTGCCTCATCTGCGGAGACCGCCAGGACCTGGAGCAGCCGGACCGGGTGGACATGCT
GCAGGAGCCGCTGCTGGAGGCGCTAAAGGTCTACGTGCGGAAGCGGAGGCCCAGCCGCCCCCACATGTTCCCCAAGATGCTAATGAAGAT
TACTGACCTGCGAAGCATCAGCGCCAAGGGGGCTGAGCGGGTGATCACGCTGAAGATGGAGATCCCGGGCTCCATGCCGCCTCTCATCCA
GGAAATGTTGGAGAACTCAGAGGGCCTGGACACTCTGAGCGGACAGCCGGGGGGTGGGGGGCGGGACGGGGGTGGCCTGGCCCCCCCGCC
AGGCAGCTGTAGCCCCAGCCTCAGCCCCAGCTCCAACAGAAGCAGCCCGGCCACCCACTCCCCGTGACCGCCCACGCCACATGGACACAG
CCCTCGCCCTCCGCCCCGGCTTTTCTCTGCCTTTCTACCGACCATGTGACCCCGCACCAGCCCTGCCCCCACCTGCCCTCCCGGGCAGTA
CTGGGGACCTTCCCTGGGGGACGGGGAGGGAGGAGGCAGCGACTCCTTGGACAGAGGCCTGGGCCCTCAGTGGACTGCCTGCTCCCACAG
CCTGGGCTGACGTCAGAGGCCGAGGCCAGGAACTGAGTGAGGCCCCTGGTCCTGGGTCTCAGGATGGGTCCTGGGGGCCTCGTGTTCATC
AAGACACCCCTCTGCCCAGCTCACCACATCTTCATCACCAGCAAACGCCAGGACTTGGCTCCCCCATCCTCAGAACTCACAAGCCATTGC
TCCCCAGCTGGGGAACCTCAACCTCCCCCCTGCCTCGGTTGGTGACAGAGGGGGTGGGACAGGGGCGGGGGGTTCCCCCTGTACATACCC
TGCCATACCAACCCCAGGTATTAATTCTCGCTGGTTTTGTTTTTATTTTAATTTTTTTGTTTTGATTTTTTTAATAAGAATTTTCATTTT

>60916_60916_1_NUMA1-RARA_NUMA1_chr11_71717080_ENST00000351960_RARA_chr17_38504567_ENST00000254066_length(amino acids)=1170AA_BP=767
MSGITKMTLHATRGAALLSWVNSLHVADPVEAVLQLQDCSIFIKIIDRIHGTEEGQQILKQPVSERLDFVCSFLQKNRKHPSSPECLVSA
QKVLEGSELELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGLNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQ
AKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALL
NEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQE
WLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQVEELSKKLADSDQASKVQQQKLKAVQAQGG
ESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAE
QTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPGEPASPIS
QRLPPKVESLESLYFTPIPARSQAPLESSLDSLGDVFLDSGRKTRSARRRTTQIINITMTKKLDVEEPDSANSSFYSTRSAPASQASLRA
TSSTQSLARLGSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPAIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGV
SACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVR
KAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQD
TMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPH
MFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP

--------------------------------------------------------------
>60916_60916_2_NUMA1-RARA_NUMA1_chr11_71717080_ENST00000351960_RARA_chr17_38504567_ENST00000394089_length(transcript)=3772nt_BP=2456nt
GTGCTGGAGAGGCCGCTGCGAGCGGAAGGCCTCCTCCATAACCGAGTCCGAAAGGGCAGAATCTATGGGGGTGGAAACTAATTCTAAGCC
AGACTGCTGGAGATCACCCTGTTCTAGTGTGTGGAGGCTTCCACCAGGAGGCGCATTGGAGTGACTGTCTGGCATCACCAAGATGACACT
CCACGCCACCCGGGGGGCTGCACTCCTCTCTTGGGTGAACAGTCTACACGTGGCTGACCCTGTGGAGGCTGTGCTGCAGCTCCAGGACTG
CAGCATCTTCATCAAGATCATTGACAGAATCCATGGCACTGAAGAGGGACAGCAAATCTTGAAGCAGCCGGTGTCAGAGAGACTGGACTT
TGTGTGCAGTTTTCTGCAGAAAAATCGAAAACATCCCTCTTCCCCAGAATGCCTGGTATCTGCACAGAAGGTGCTAGAGGGATCAGAGCT
GGAACTGGCGAAGATGACCATGCTGCTCTTATACCACTCTACCATGAGCTCCAAAAGTCCCAGGGACTGGGAACAGTTTGAATATAAAAT
TCAGGCTGAGTTGGCTGTCATTCTTAAATTTGTGCTGGACCATGAGGACGGGCTAAACCTTAATGAGGACCTAGAGAACTTCCTACAGAA
AGCTCCTGTGCCTTCTACCTGTTCTAGCACATTCCCTGAAGAGCTCTCCCCACCTAGCCACCAGGCCAAGAGGGAGATTCGCTTCCTAGA
GCTACAGAAGGTTGCCTCCTCTTCCAGTGGGAACAACTTTCTCTCAGGTTCTCCAGCTTCTCCCATGGGTGATATCCTGCAGACCCCACA
GTTCCAGATGAGACGGCTGAAGAAGCAGCTTGCTGATGAGAGAAGTAATAGGGATGAGCTGGAGCTGGAGCTAGCTGAGAACCGCAAGCT
CCTCACCGAGAAGGATGCACAGATAGCCATGATGCAGCAGCGCATTGACCGCCTAGCCCTGCTGAATGAGAAGCAGGCGGCCAGCCCACT
GGAGCCCAAGGAGCTTGAGGAGCTGCGTGACAAGAATGAGAGCCTTACCATGCGGCTGCATGAAACCCTGAAGCAGTGCCAGGACCTGAA
GACAGAGAAGAGCCAGATGGATCGCAAAATCAACCAGCTTTCGGAGGAGAATGGAGACCTTTCCTTTAAGCTGCGGGAGTTTGCCAGTCA
TCTGCAGCAGCTACAGGATGCCCTCAATGAGCTGACGGAGGAGCACAGCAAGGCCACTCAGGAGTGGCTAGAGAAGCAGGCCCAGCTGGA
GAAGGAGCTCAGCGCAGCCCTGCAGGACAAGAAATGCCTTGAAGAGAAGAACGAAATCCTTCAGGGAAAACTTTCACAGCTGGAAGAACA
CTTGTCCCAGCTGCAGGATAACCCACCCCAGGAGAAGGGCGAGGTGCTGGGTGATGTCTTGCAGGTGGAAGAACTGAGTAAGAAACTGGC
TGACTCTGACCAAGCCAGCAAGGTGCAGCAGCAGAAGCTGAAGGCTGTCCAGGCTCAGGGAGGCGAGAGCCAGCAGGAGGCCCAGCGCCT
CCAGGCCCAGCTGAATGAACTGCAAGCCCAGTTGAGCCAGAAGGAGCAGGCAGCTGAGCACTATAAGCTGCAGATGGAGAAAGCCAAAAC
ACATTATGATGCCAAGAAGCAGCAGAACCAAGAGCTGCAGGAGCAGCTGCGGAGCCTGGAGCAGCTGCAGAAGGAAAACAAAGAGCTGCG
AGCTGAAGCTGAACGGCTGGGCCATGAGCTACAGCAGGCTGGGCTGAAGACCAAGGAGGCTGAACAGACCTGCCGCCACCTTACTGCCCA
GGTGCGCAGCCTGGAGGCACAGGTTGCCCATGCAGACCAGCAGCTTCGAGACCTGGGCAAATTCCAGGTGGCAACTGATGCTTTAAAGAG
CCGTGAGCCCCAGGCTAAGCCCCAGCTGGACTTGAGTATTGACAGCCTGGATCTGAGCTGCGAGGAGGGGACCCCACTCAGTATCACCAG
CAAGCTGCCTCGTACCCAGCCAGACGGCACCAGCGTCCCTGGAGAACCAGCCTCACCTATCTCCCAGCGCCTGCCCCCCAAGGTAGAATC
CCTGGAGAGTCTCTACTTCACTCCCATCCCTGCTCGGAGTCAGGCCCCCCTGGAGAGCAGCCTGGACTCCCTGGGAGACGTCTTCCTGGA
CTCGGGTCGTAAGACCCGCTCCGCTCGTCGGCGCACCACGCAGATCATCAACATCACCATGACCAAGAAGCTAGATGTGGAAGAGCCAGA
CAGCGCCAACTCATCGTTCTACAGCACGCGGTCTGCTCCTGCTTCCCAGGCTAGCCTGCGAGCCACCTCCTCTACTCAGTCTCTAGCTCG
CCTGGGTTCTCCCGATTATGGCAACTCAGCCCTGCTCAGCTTGCCTGGCTACCGCCCCACCACTCGCAGTTCTGCTCGTCGTTCCCAGGC
CGGGGTGTCCAGTGGGGCCCCTCCAGCCATTGAGACCCAGAGCAGCAGTTCTGAAGAGATAGTGCCCAGCCCTCCCTCGCCACCCCCTCT
ACCCCGCATCTACAAGCCTTGCTTTGTCTGTCAGGACAAGTCCTCAGGCTACCACTATGGGGTCAGCGCCTGTGAGGGCTGCAAGGGCTT
CTTCCGCCGCAGCATCCAGAAGAACATGGTGTACACGTGTCACCGGGACAAGAACTGCATCATCAACAAGGTGACCCGGAACCGCTGCCA
GTACTGCCGACTGCAGAAGTGCTTTGAAGTGGGCATGTCCAAGGAGTCTGTGAGAAACGACCGAAACAAGAAGAAGAAGGAGGTGCCCAA
GCCCGAGTGCTCTGAGAGCTACACGCTGACGCCGGAGGTGGGGGAGCTCATTGAGAAGGTGCGCAAAGCGCACCAGGAAACCTTCCCTGC
CCTCTGCCAGCTGGGCAAATACACTACGAACAACAGCTCAGAACAACGTGTCTCTCTGGACATTGACCTCTGGGACAAGTTCAGTGAACT
CTCCACCAAGTGCATCATTAAGACTGTGGAGTTCGCCAAGCAGCTGCCCGGCTTCACCACCCTCACCATCGCCGACCAGATCACCCTCCT
CAAGGCTGCCTGCCTGGACATCCTGATCCTGCGGATCTGCACGCGGTACACGCCCGAGCAGGACACCATGACCTTCTCGGACGGGCTGAC
CCTGAACCGGACCCAGATGCACAACGCTGGCTTCGGCCCCCTCACCGACCTGGTCTTTGCCTTCGCCAACCAGCTGCTGCCCCTGGAGAT
GGATGATGCGGAGACGGGGCTGCTCAGCGCCATCTGCCTCATCTGCGGAGACCGCCAGGACCTGGAGCAGCCGGACCGGGTGGACATGCT
GCAGGAGCCGCTGCTGGAGGCGCTAAAGGTCTACGTGCGGAAGCGGAGGCCCAGCCGCCCCCACATGTTCCCCAAGATGCTAATGAAGAT
TACTGACCTGCGAAGCATCAGCGCCAAGGGGGCTGAGCGGGTGATCACGCTGAAGATGGAGATCCCGGGCTCCATGCCGCCTCTCATCCA
GGAAATGTTGGAGAACTCAGAGGGCCTGGACACTCTGAGCGGACAGCCGGGGGGTGGGGGGCGGGACGGGGGTGGCCTGGCCCCCCCGCC
AGGCAGCTGTAGCCCCAGCCTCAGCCCCAGCTCCAACAGAAGCAGCCCGGCCACCCACTCCCCGTGACCGCCCACGCCACATGGACACAG

>60916_60916_2_NUMA1-RARA_NUMA1_chr11_71717080_ENST00000351960_RARA_chr17_38504567_ENST00000394089_length(amino acids)=1170AA_BP=767
MSGITKMTLHATRGAALLSWVNSLHVADPVEAVLQLQDCSIFIKIIDRIHGTEEGQQILKQPVSERLDFVCSFLQKNRKHPSSPECLVSA
QKVLEGSELELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGLNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQ
AKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALL
NEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQE
WLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQVEELSKKLADSDQASKVQQQKLKAVQAQGG
ESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAE
QTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPGEPASPIS
QRLPPKVESLESLYFTPIPARSQAPLESSLDSLGDVFLDSGRKTRSARRRTTQIINITMTKKLDVEEPDSANSSFYSTRSAPASQASLRA
TSSTQSLARLGSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPAIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGV
SACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVR
KAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQD
TMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPH
MFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP

--------------------------------------------------------------
>60916_60916_3_NUMA1-RARA_NUMA1_chr11_71717080_ENST00000393695_RARA_chr17_38504567_ENST00000254066_length(transcript)=7805nt_BP=6024nt
AAGTACAGGCCGGGGTCCGGAAGCGGTGATACCCCTTCTCTTTCCCAGTGGCCCTCAAACTTCCTTTTCCCGGGTCCTTAAGCGGGCCCC
GCCGACAGAGGCCAATCAGAGGGCAGCGCGAGGGGGCGGGGCCATAGTTTAAACTAATTGTGCGCTCACAGCGCTGGCGCGAGCCCACGA
AGAGGTACGATTCCGGAGAATCGCGAGGCAGAGCGGGAGCGCGCAGCCAGGTGGAAACTAATTCTAAGCCAGACTGCTGGAGATCACCCT
GTTCTAGTGTGTGGAGGCTTCCACCAGGAGGCGCATTGGAGTGACTGTCTGGCATCACCAAGATGACACTCCACGCCACCCGGGGGGCTG
CACTCCTCTCTTGGGTGAACAGTCTACACGTGGCTGACCCTGTGGAGGCTGTGCTGCAGCTCCAGGACTGCAGCATCTTCATCAAGATCA
TTGACAGAATCCATGGCACTGAAGAGGGACAGCAAATCTTGAAGCAGCCGGTGTCAGAGAGACTGGACTTTGTGTGCAGTTTTCTGCAGA
AAAATCGAAAACATCCCTCTTCCCCAGAATGCCTGGTATCTGCACAGAAGGTGCTAGAGGGATCAGAGCTGGAACTGGCGAAGATGACCA
TGCTGCTCTTATACCACTCTACCATGAGCTCCAAAAGTCCCAGGGACTGGGAACAGTTTGAATATAAAATTCAGGCTGAGTTGGCTGTCA
TTCTTAAATTTGTGCTGGACCATGAGGACGGGCTAAACCTTAATGAGGACCTAGAGAACTTCCTACAGAAAGCTCCTGTGCCTTCTACCT
GTTCTAGCACATTCCCTGAAGAGCTCTCCCCACCTAGCCACCAGGCCAAGAGGGAGATTCGCTTCCTAGAGCTACAGAAGGTTGCCTCCT
CTTCCAGTGGGAACAACTTTCTCTCAGGTTCTCCAGCTTCTCCCATGGGTGATATCCTGCAGACCCCACAGTTCCAGATGAGACGGCTGA
AGAAGCAGCTTGCTGATGAGAGAAGTAATAGGGATGAGCTGGAGCTGGAGCTAGCTGAGAACCGCAAGCTCCTCACCGAGAAGGATGCAC
AGATAGCCATGATGCAGCAGCGCATTGACCGCCTAGCCCTGCTGAATGAGAAGCAGGCGGCCAGCCCACTGGAGCCCAAGGAGCTTGAGG
AGCTGCGTGACAAGAATGAGAGCCTTACCATGCGGCTGCATGAAACCCTGAAGCAGTGCCAGGACCTGAAGACAGAGAAGAGCCAGATGG
ATCGCAAAATCAACCAGCTTTCGGAGGAGAATGGAGACCTTTCCTTTAAGCTGCGGGAGTTTGCCAGTCATCTGCAGCAGCTACAGGATG
CCCTCAATGAGCTGACGGAGGAGCACAGCAAGGCCACTCAGGAGTGGCTAGAGAAGCAGGCCCAGCTGGAGAAGGAGCTCAGCGCAGCCC
TGCAGGACAAGAAATGCCTTGAAGAGAAGAACGAAATCCTTCAGGGAAAACTTTCACAGCTGGAAGAACACTTGTCCCAGCTGCAGGATA
ACCCACCCCAGGAGAAGGGCGAGGTGCTGGGTGATGTCTTGCAGCTGGAAACCTTGAAGCAAGAGGCAGCCACTCTTGCTGCAAACAACA
CACAGCTCCAAGCCAGGGTAGAGATGCTGGAGACTGAGCGAGGCCAGCAGGAAGCCAAGCTGCTTGCTGAGCGGGGCCACTTCGAAGAAG
AAAAGCAGCAGCTGTCTAGCCTGATCACTGACCTGCAGAGCTCCATCTCCAACCTCAGCCAGGCCAAGGAAGAGCTGGAGCAGGCCTCCC
AGGCTCATGGGGCCCGGTTGACTGCCCAGGTGGCCTCTCTGACCTCTGAGCTCACCACACTCAATGCCACCATCCAGCAACAGGATCAAG
AACTGGCTGGCCTGAAGCAGCAGGCCAAAGAGAAGCAGGCCCAGCTAGCACAGACCCTCCAACAGCAAGAACAGGCCTCCCAGGGCCTCC
GCCACCAGGTGGAGCAGCTAAGCAGTAGCCTGAAGCAGAAGGAGCAGCAGTTGAAGGAGGTAGCGGAGAAGCAGGAGGCAACTAGGCAGG
ACCATGCCCAGCAACTGGCCACTGCTGCAGAGGAGCGAGAGGCCTCCTTAAGGGAGCGGGATGCGGCTCTCAAGCAGCTGGAGGCACTGG
AGAAGGAGAAGGCTGCCAAGCTGGAGATTCTGCAGCAGCAACTTCAGGTGGCTAATGAAGCCCGGGACAGTGCCCAGACCTCAGTGACAC
AGGCCCAGCGGGAGAAGGCAGAGCTGAGCCGGAAGGTGGAGGAACTCCAGGCCTGTGTTGAGACAGCCCGCCAGGAACAGCATGAGGCCC
AGGCCCAGGTTGCAGAGCTAGAGTTGCAGCTGCGGTCTGAGCAGCAAAAAGCAACTGAGAAAGAAAGGGTGGCCCAGGAGAAGGACCAGC
TCCAGGAGCAGCTCCAGGCCCTCAAAGAGTCCTTGAAGGTCACCAAGGGCAGCCTTGAAGAGGAGAAGCGCAGGGCTGCAGATGCCCTGG
AAGAGCAGCAGCGTTGTATCTCTGAGCTGAAGGCAGAGACCCGAAGCCTGGTGGAGCAGCATAAGCGGGAACGAAAGGAGCTGGAAGAAG
AGAGGGCTGGGCGCAAGGGGCTGGAGGCTCGATTACAGCAGCTTGGGGAGGCCCATCAGGCTGAGACTGAAGTCCTGCGGCGGGAGCTGG
CAGAGGCCATGGCTGCCCAGCACACAGCTGAGAGTGAGTGTGAGCAGCTCGTCAAAGAAGTAGCTGCCTGGCGTGAGCGGTATGAGGATA
GCCAGCAAGAGGAGGCACAGTATGGCGCCATGTTCCAGGAACAGCTGATGACTTTGAAGGAGGAATGTGAGAAGGCCCGCCAGGAGCTGC
AGGAGGCAAAGGAGAAGGTGGCAGGCATAGAATCCCACAGCGAGCTCCAGATAAGCCGGCAGCAGAACGAACTAGCTGAGCTCCATGCCA
ACCTGGCCAGAGCACTCCAGCAGGTCCAAGAGAAGGAAGTCAGGGCCCAGAAGCTTGCAGATGACCTCTCCACTCTGCAGGAAAAGATGG
CTGCCACCAGCAAAGAGGTGGCCCGCTTGGAGACCTTGGTGCGCAAGGCAGGTGAGCAGCAGGAAACAGCCTCCCGGGAGTTAGTCAAGG
AGCCTGCGAGGGCAGGAGACAGACAGCCCGAGTGGCTGGAAGAGCAACAGGGACGCCAGTTCTGCAGCACACAGGCAGCGCTGCAGGCTA
TGGAGCGGGAGGCAGAGCAGATGGGCAATGAGCTGGAACGGCTGCGGGCCGCGCTGATGGAGAGCCAGGGGCAGCAGCAGGAGGAGCGTG
GGCAGCAGGAAAGGGAGGTGGCGCGGCTGACCCAGGAGCGGGGCCGTGCCCAGGCTGACCTTGCCCTGGAGAAGGCGGCCAGAGCAGAGC
TTGAGATGCGGCTGCAGAACGCCCTCAACGAGCAGCGTGTGGAGTTCGCTACCCTGCAAGAGGCACTGGCTCATGCCCTGACGGAAAAGG
AAGGCAAGGACCAGGAGTTGGCCAAGCTTCGTGGTCTGGAGGCAGCCCAGATAAAAGAGCTGGAGGAACTTCGGCAAACCGTGAAGCAAC
TGAAGGAACAGCTGGCTAAGAAAGAAAAGGAGCACGCATCTGGCTCAGGAGCCCAATCTGAGGCTGCTGGCAGGACAGAGCCAACAGGCC
CCAAGCTGGAGGCACTGCGGGCAGAGGTGAGCAAGCTGGAACAGCAATGCCAGAAGCAGCAGGAGCAGGCTGACAGCCTGGAACGCAGCC
TCGAGGCTGAGCGGGCCTCCCGGGCTGAGCGGGACAGTGCTCTGGAGACTCTGCAGGGCCAGTTAGAGGAGAAGGCCCAGGAGCTAGGGC
ACAGTCAGAGTGCCTTAGCCTCGGCCCAACGGGAGTTGGCTGCCTTCCGCACCAAGGTACAAGACCACAGCAAGGCTGAAGATGAGTGGA
AGGCCCAGGTGGCCCGGGGCCGGCAAGAGGCTGAGAGGAAAAATAGCCTCATCAGCAGCTTGGAGGAGGAGGTGTCCATCCTGAATCGCC
AGGTCCTGGAGAAGGAGGGGGAGAGCAAGGAGTTGAAGCGGCTGGTGATGGCCGAGTCAGAGAAGAGCCAGAAGCTGGAGGAGAGGCTGC
GCCTGCTGCAGGCAGAGACAGCCAGCAACAGTGCCAGAGCTGCAGAACGCAGCTCTGCTCTGCGGGAGGAGGTGCAGAGCCTCCGGGAGG
AGGCTGAGAAACAGCGGGTGGCTTCAGAGAACCTGCGGCAGGAGCTGACCTCACAGGCTGAGCGTGCGGAGGAGCTGGGCCAAGAATTGA
AGGCGTGGCAGGAGAAGTTCTTCCAGAAAGAGCAGGCCCTCTCCACCCTGCAGCTCGAGCACACCAGCACACAGGCCCTGGTGAGTGAGC
TGCTGCCAGCTAAGCACCTCTGCCAGCAGCTGCAGGCCGAGCAGGCCGCTGCCGAGAAACGCCACCGTGAGGAGCTGGAGCAGAGCAAGC
AGGCCGCTGGGGGACTGCGGGCAGAGCTGCTGCGGGCCCAGCGGGAGCTTGGGGAGCTGATTCCTCTGCGGCAGAAGGTGGCAGAGCAGG
AGCGAACAGCTCAGCAGCTGCGGGCAGAGAAGGCCAGCTATGCAGAGCAGCTGAGCATGCTGAAGAAGGCGCATGGCCTGCTGGCAGAGG
AGAACCGGGGGCTGGGTGAGCGGGCCAACCTTGGCCGGCAGTTTCTGGAAGTGGAGTTGGACCAGGCCCGGGAGAAGTATGTCCAAGAGT
TGGCAGCCGTACGTGCTGATGCTGAGACCCGTCTGGCTGAGGTGCAGCGAGAAGCACAGAGCACTGCCCGGGAGCTGGAGGTGATGACTG
CCAAGTATGAGGGTGCCAAGGTCAAGGTCCTGGAGGAGAGGCAGCGGTTCCAGGAAGAGAGGCAGAAACTCACTGCCCAGGTGGAGCAGC
TAGAGGTATTTCAGAGAGAGCAAACTAAGCAGGTGGAAGAACTGAGTAAGAAACTGGCTGACTCTGACCAAGCCAGCAAGGTGCAGCAGC
AGAAGCTGAAGGCTGTCCAGGCTCAGGGAGGCGAGAGCCAGCAGGAGGCCCAGCGCCTCCAGGCCCAGCTGAATGAACTGCAAGCCCAGT
TGAGCCAGAAGGAGCAGGCAGCTGAGCACTATAAGCTGCAGATGGAGAAAGCCAAAACACATTATGATGCCAAGAAGCAGCAGAACCAAG
AGCTGCAGGAGCAGCTGCGGAGCCTGGAGCAGCTGCAGAAGGAAAACAAAGAGCTGCGAGCTGAAGCTGAACGGCTGGGCCATGAGCTAC
AGCAGGCTGGGCTGAAGACCAAGGAGGCTGAACAGACCTGCCGCCACCTTACTGCCCAGGTGCGCAGCCTGGAGGCACAGGTTGCCCATG
CAGACCAGCAGCTTCGAGACCTGGGCAAATTCCAGGTGGCAACTGATGCTTTAAAGAGCCGTGAGCCCCAGGCTAAGCCCCAGCTGGACT
TGAGTATTGACAGCCTGGATCTGAGCTGCGAGGAGGGGACCCCACTCAGTATCACCAGCAAGCTGCCTCGTACCCAGCCAGACGGCACCA
GCGTCCCTGGAGAACCAGCCTCACCTATCTCCCAGCGCCTGCCCCCCAAGGTAGAATCCCTGGAGAGTCTCTACTTCACTCCCATCCCTG
CTCGGAGTCAGGCCCCCCTGGAGAGCAGCCTGGACTCCCTGGGAGACGTCTTCCTGGACTCGGGTCGTAAGACCCGCTCCGCTCGTCGGC
GCACCACGCAGATCATCAACATCACCATGACCAAGAAGCTAGATGTGGAAGAGCCAGACAGCGCCAACTCATCGTTCTACAGCACGCGGT
CTGCTCCTGCTTCCCAGGCTAGCCTGCGAGCCACCTCCTCTACTCAGTCTCTAGCTCGCCTGGGTTCTCCCGATTATGGCAACTCAGCCC
TGCTCAGCTTGCCTGGCTACCGCCCCACCACTCGCAGTTCTGCTCGTCGTTCCCAGGCCGGGGTGTCCAGTGGGGCCCCTCCAGCCATTG
AGACCCAGAGCAGCAGTTCTGAAGAGATAGTGCCCAGCCCTCCCTCGCCACCCCCTCTACCCCGCATCTACAAGCCTTGCTTTGTCTGTC
AGGACAAGTCCTCAGGCTACCACTATGGGGTCAGCGCCTGTGAGGGCTGCAAGGGCTTCTTCCGCCGCAGCATCCAGAAGAACATGGTGT
ACACGTGTCACCGGGACAAGAACTGCATCATCAACAAGGTGACCCGGAACCGCTGCCAGTACTGCCGACTGCAGAAGTGCTTTGAAGTGG
GCATGTCCAAGGAGTCTGTGAGAAACGACCGAAACAAGAAGAAGAAGGAGGTGCCCAAGCCCGAGTGCTCTGAGAGCTACACGCTGACGC
CGGAGGTGGGGGAGCTCATTGAGAAGGTGCGCAAAGCGCACCAGGAAACCTTCCCTGCCCTCTGCCAGCTGGGCAAATACACTACGAACA
ACAGCTCAGAACAACGTGTCTCTCTGGACATTGACCTCTGGGACAAGTTCAGTGAACTCTCCACCAAGTGCATCATTAAGACTGTGGAGT
TCGCCAAGCAGCTGCCCGGCTTCACCACCCTCACCATCGCCGACCAGATCACCCTCCTCAAGGCTGCCTGCCTGGACATCCTGATCCTGC
GGATCTGCACGCGGTACACGCCCGAGCAGGACACCATGACCTTCTCGGACGGGCTGACCCTGAACCGGACCCAGATGCACAACGCTGGCT
TCGGCCCCCTCACCGACCTGGTCTTTGCCTTCGCCAACCAGCTGCTGCCCCTGGAGATGGATGATGCGGAGACGGGGCTGCTCAGCGCCA
TCTGCCTCATCTGCGGAGACCGCCAGGACCTGGAGCAGCCGGACCGGGTGGACATGCTGCAGGAGCCGCTGCTGGAGGCGCTAAAGGTCT
ACGTGCGGAAGCGGAGGCCCAGCCGCCCCCACATGTTCCCCAAGATGCTAATGAAGATTACTGACCTGCGAAGCATCAGCGCCAAGGGGG
CTGAGCGGGTGATCACGCTGAAGATGGAGATCCCGGGCTCCATGCCGCCTCTCATCCAGGAAATGTTGGAGAACTCAGAGGGCCTGGACA
CTCTGAGCGGACAGCCGGGGGGTGGGGGGCGGGACGGGGGTGGCCTGGCCCCCCCGCCAGGCAGCTGTAGCCCCAGCCTCAGCCCCAGCT
CCAACAGAAGCAGCCCGGCCACCCACTCCCCGTGACCGCCCACGCCACATGGACACAGCCCTCGCCCTCCGCCCCGGCTTTTCTCTGCCT
TTCTACCGACCATGTGACCCCGCACCAGCCCTGCCCCCACCTGCCCTCCCGGGCAGTACTGGGGACCTTCCCTGGGGGACGGGGAGGGAG
GAGGCAGCGACTCCTTGGACAGAGGCCTGGGCCCTCAGTGGACTGCCTGCTCCCACAGCCTGGGCTGACGTCAGAGGCCGAGGCCAGGAA
CTGAGTGAGGCCCCTGGTCCTGGGTCTCAGGATGGGTCCTGGGGGCCTCGTGTTCATCAAGACACCCCTCTGCCCAGCTCACCACATCTT
CATCACCAGCAAACGCCAGGACTTGGCTCCCCCATCCTCAGAACTCACAAGCCATTGCTCCCCAGCTGGGGAACCTCAACCTCCCCCCTG
CCTCGGTTGGTGACAGAGGGGGTGGGACAGGGGCGGGGGGTTCCCCCTGTACATACCCTGCCATACCAACCCCAGGTATTAATTCTCGCT

>60916_60916_3_NUMA1-RARA_NUMA1_chr11_71717080_ENST00000393695_RARA_chr17_38504567_ENST00000254066_length(amino acids)=2306AA_BP=1903
MSGITKMTLHATRGAALLSWVNSLHVADPVEAVLQLQDCSIFIKIIDRIHGTEEGQQILKQPVSERLDFVCSFLQKNRKHPSSPECLVSA
QKVLEGSELELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGLNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQ
AKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALL
NEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQE
WLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERG
QQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQ
LAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQL
QVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVT
KGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECE
QLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVR
AQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL
RAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEA
AQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSAL
ETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRL
VMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALS
TLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYA
EQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQ
RFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQM
EKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVAT
DALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPGEPASPISQRLPPKVESLESLYFTPIPARSQAPLESSLDSLG
DVFLDSGRKTRSARRRTTQIINITMTKKLDVEEPDSANSSFYSTRSAPASQASLRATSSTQSLARLGSPDYGNSALLSLPGYRPTTRSSA
RRSQAGVSSGAPPAIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVT
RNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWD
KFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQL
LPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSM

--------------------------------------------------------------
>60916_60916_4_NUMA1-RARA_NUMA1_chr11_71717080_ENST00000393695_RARA_chr17_38504567_ENST00000394089_length(transcript)=7340nt_BP=6024nt
AAGTACAGGCCGGGGTCCGGAAGCGGTGATACCCCTTCTCTTTCCCAGTGGCCCTCAAACTTCCTTTTCCCGGGTCCTTAAGCGGGCCCC
GCCGACAGAGGCCAATCAGAGGGCAGCGCGAGGGGGCGGGGCCATAGTTTAAACTAATTGTGCGCTCACAGCGCTGGCGCGAGCCCACGA
AGAGGTACGATTCCGGAGAATCGCGAGGCAGAGCGGGAGCGCGCAGCCAGGTGGAAACTAATTCTAAGCCAGACTGCTGGAGATCACCCT
GTTCTAGTGTGTGGAGGCTTCCACCAGGAGGCGCATTGGAGTGACTGTCTGGCATCACCAAGATGACACTCCACGCCACCCGGGGGGCTG
CACTCCTCTCTTGGGTGAACAGTCTACACGTGGCTGACCCTGTGGAGGCTGTGCTGCAGCTCCAGGACTGCAGCATCTTCATCAAGATCA
TTGACAGAATCCATGGCACTGAAGAGGGACAGCAAATCTTGAAGCAGCCGGTGTCAGAGAGACTGGACTTTGTGTGCAGTTTTCTGCAGA
AAAATCGAAAACATCCCTCTTCCCCAGAATGCCTGGTATCTGCACAGAAGGTGCTAGAGGGATCAGAGCTGGAACTGGCGAAGATGACCA
TGCTGCTCTTATACCACTCTACCATGAGCTCCAAAAGTCCCAGGGACTGGGAACAGTTTGAATATAAAATTCAGGCTGAGTTGGCTGTCA
TTCTTAAATTTGTGCTGGACCATGAGGACGGGCTAAACCTTAATGAGGACCTAGAGAACTTCCTACAGAAAGCTCCTGTGCCTTCTACCT
GTTCTAGCACATTCCCTGAAGAGCTCTCCCCACCTAGCCACCAGGCCAAGAGGGAGATTCGCTTCCTAGAGCTACAGAAGGTTGCCTCCT
CTTCCAGTGGGAACAACTTTCTCTCAGGTTCTCCAGCTTCTCCCATGGGTGATATCCTGCAGACCCCACAGTTCCAGATGAGACGGCTGA
AGAAGCAGCTTGCTGATGAGAGAAGTAATAGGGATGAGCTGGAGCTGGAGCTAGCTGAGAACCGCAAGCTCCTCACCGAGAAGGATGCAC
AGATAGCCATGATGCAGCAGCGCATTGACCGCCTAGCCCTGCTGAATGAGAAGCAGGCGGCCAGCCCACTGGAGCCCAAGGAGCTTGAGG
AGCTGCGTGACAAGAATGAGAGCCTTACCATGCGGCTGCATGAAACCCTGAAGCAGTGCCAGGACCTGAAGACAGAGAAGAGCCAGATGG
ATCGCAAAATCAACCAGCTTTCGGAGGAGAATGGAGACCTTTCCTTTAAGCTGCGGGAGTTTGCCAGTCATCTGCAGCAGCTACAGGATG
CCCTCAATGAGCTGACGGAGGAGCACAGCAAGGCCACTCAGGAGTGGCTAGAGAAGCAGGCCCAGCTGGAGAAGGAGCTCAGCGCAGCCC
TGCAGGACAAGAAATGCCTTGAAGAGAAGAACGAAATCCTTCAGGGAAAACTTTCACAGCTGGAAGAACACTTGTCCCAGCTGCAGGATA
ACCCACCCCAGGAGAAGGGCGAGGTGCTGGGTGATGTCTTGCAGCTGGAAACCTTGAAGCAAGAGGCAGCCACTCTTGCTGCAAACAACA
CACAGCTCCAAGCCAGGGTAGAGATGCTGGAGACTGAGCGAGGCCAGCAGGAAGCCAAGCTGCTTGCTGAGCGGGGCCACTTCGAAGAAG
AAAAGCAGCAGCTGTCTAGCCTGATCACTGACCTGCAGAGCTCCATCTCCAACCTCAGCCAGGCCAAGGAAGAGCTGGAGCAGGCCTCCC
AGGCTCATGGGGCCCGGTTGACTGCCCAGGTGGCCTCTCTGACCTCTGAGCTCACCACACTCAATGCCACCATCCAGCAACAGGATCAAG
AACTGGCTGGCCTGAAGCAGCAGGCCAAAGAGAAGCAGGCCCAGCTAGCACAGACCCTCCAACAGCAAGAACAGGCCTCCCAGGGCCTCC
GCCACCAGGTGGAGCAGCTAAGCAGTAGCCTGAAGCAGAAGGAGCAGCAGTTGAAGGAGGTAGCGGAGAAGCAGGAGGCAACTAGGCAGG
ACCATGCCCAGCAACTGGCCACTGCTGCAGAGGAGCGAGAGGCCTCCTTAAGGGAGCGGGATGCGGCTCTCAAGCAGCTGGAGGCACTGG
AGAAGGAGAAGGCTGCCAAGCTGGAGATTCTGCAGCAGCAACTTCAGGTGGCTAATGAAGCCCGGGACAGTGCCCAGACCTCAGTGACAC
AGGCCCAGCGGGAGAAGGCAGAGCTGAGCCGGAAGGTGGAGGAACTCCAGGCCTGTGTTGAGACAGCCCGCCAGGAACAGCATGAGGCCC
AGGCCCAGGTTGCAGAGCTAGAGTTGCAGCTGCGGTCTGAGCAGCAAAAAGCAACTGAGAAAGAAAGGGTGGCCCAGGAGAAGGACCAGC
TCCAGGAGCAGCTCCAGGCCCTCAAAGAGTCCTTGAAGGTCACCAAGGGCAGCCTTGAAGAGGAGAAGCGCAGGGCTGCAGATGCCCTGG
AAGAGCAGCAGCGTTGTATCTCTGAGCTGAAGGCAGAGACCCGAAGCCTGGTGGAGCAGCATAAGCGGGAACGAAAGGAGCTGGAAGAAG
AGAGGGCTGGGCGCAAGGGGCTGGAGGCTCGATTACAGCAGCTTGGGGAGGCCCATCAGGCTGAGACTGAAGTCCTGCGGCGGGAGCTGG
CAGAGGCCATGGCTGCCCAGCACACAGCTGAGAGTGAGTGTGAGCAGCTCGTCAAAGAAGTAGCTGCCTGGCGTGAGCGGTATGAGGATA
GCCAGCAAGAGGAGGCACAGTATGGCGCCATGTTCCAGGAACAGCTGATGACTTTGAAGGAGGAATGTGAGAAGGCCCGCCAGGAGCTGC
AGGAGGCAAAGGAGAAGGTGGCAGGCATAGAATCCCACAGCGAGCTCCAGATAAGCCGGCAGCAGAACGAACTAGCTGAGCTCCATGCCA
ACCTGGCCAGAGCACTCCAGCAGGTCCAAGAGAAGGAAGTCAGGGCCCAGAAGCTTGCAGATGACCTCTCCACTCTGCAGGAAAAGATGG
CTGCCACCAGCAAAGAGGTGGCCCGCTTGGAGACCTTGGTGCGCAAGGCAGGTGAGCAGCAGGAAACAGCCTCCCGGGAGTTAGTCAAGG
AGCCTGCGAGGGCAGGAGACAGACAGCCCGAGTGGCTGGAAGAGCAACAGGGACGCCAGTTCTGCAGCACACAGGCAGCGCTGCAGGCTA
TGGAGCGGGAGGCAGAGCAGATGGGCAATGAGCTGGAACGGCTGCGGGCCGCGCTGATGGAGAGCCAGGGGCAGCAGCAGGAGGAGCGTG
GGCAGCAGGAAAGGGAGGTGGCGCGGCTGACCCAGGAGCGGGGCCGTGCCCAGGCTGACCTTGCCCTGGAGAAGGCGGCCAGAGCAGAGC
TTGAGATGCGGCTGCAGAACGCCCTCAACGAGCAGCGTGTGGAGTTCGCTACCCTGCAAGAGGCACTGGCTCATGCCCTGACGGAAAAGG
AAGGCAAGGACCAGGAGTTGGCCAAGCTTCGTGGTCTGGAGGCAGCCCAGATAAAAGAGCTGGAGGAACTTCGGCAAACCGTGAAGCAAC
TGAAGGAACAGCTGGCTAAGAAAGAAAAGGAGCACGCATCTGGCTCAGGAGCCCAATCTGAGGCTGCTGGCAGGACAGAGCCAACAGGCC
CCAAGCTGGAGGCACTGCGGGCAGAGGTGAGCAAGCTGGAACAGCAATGCCAGAAGCAGCAGGAGCAGGCTGACAGCCTGGAACGCAGCC
TCGAGGCTGAGCGGGCCTCCCGGGCTGAGCGGGACAGTGCTCTGGAGACTCTGCAGGGCCAGTTAGAGGAGAAGGCCCAGGAGCTAGGGC
ACAGTCAGAGTGCCTTAGCCTCGGCCCAACGGGAGTTGGCTGCCTTCCGCACCAAGGTACAAGACCACAGCAAGGCTGAAGATGAGTGGA
AGGCCCAGGTGGCCCGGGGCCGGCAAGAGGCTGAGAGGAAAAATAGCCTCATCAGCAGCTTGGAGGAGGAGGTGTCCATCCTGAATCGCC
AGGTCCTGGAGAAGGAGGGGGAGAGCAAGGAGTTGAAGCGGCTGGTGATGGCCGAGTCAGAGAAGAGCCAGAAGCTGGAGGAGAGGCTGC
GCCTGCTGCAGGCAGAGACAGCCAGCAACAGTGCCAGAGCTGCAGAACGCAGCTCTGCTCTGCGGGAGGAGGTGCAGAGCCTCCGGGAGG
AGGCTGAGAAACAGCGGGTGGCTTCAGAGAACCTGCGGCAGGAGCTGACCTCACAGGCTGAGCGTGCGGAGGAGCTGGGCCAAGAATTGA
AGGCGTGGCAGGAGAAGTTCTTCCAGAAAGAGCAGGCCCTCTCCACCCTGCAGCTCGAGCACACCAGCACACAGGCCCTGGTGAGTGAGC
TGCTGCCAGCTAAGCACCTCTGCCAGCAGCTGCAGGCCGAGCAGGCCGCTGCCGAGAAACGCCACCGTGAGGAGCTGGAGCAGAGCAAGC
AGGCCGCTGGGGGACTGCGGGCAGAGCTGCTGCGGGCCCAGCGGGAGCTTGGGGAGCTGATTCCTCTGCGGCAGAAGGTGGCAGAGCAGG
AGCGAACAGCTCAGCAGCTGCGGGCAGAGAAGGCCAGCTATGCAGAGCAGCTGAGCATGCTGAAGAAGGCGCATGGCCTGCTGGCAGAGG
AGAACCGGGGGCTGGGTGAGCGGGCCAACCTTGGCCGGCAGTTTCTGGAAGTGGAGTTGGACCAGGCCCGGGAGAAGTATGTCCAAGAGT
TGGCAGCCGTACGTGCTGATGCTGAGACCCGTCTGGCTGAGGTGCAGCGAGAAGCACAGAGCACTGCCCGGGAGCTGGAGGTGATGACTG
CCAAGTATGAGGGTGCCAAGGTCAAGGTCCTGGAGGAGAGGCAGCGGTTCCAGGAAGAGAGGCAGAAACTCACTGCCCAGGTGGAGCAGC
TAGAGGTATTTCAGAGAGAGCAAACTAAGCAGGTGGAAGAACTGAGTAAGAAACTGGCTGACTCTGACCAAGCCAGCAAGGTGCAGCAGC
AGAAGCTGAAGGCTGTCCAGGCTCAGGGAGGCGAGAGCCAGCAGGAGGCCCAGCGCCTCCAGGCCCAGCTGAATGAACTGCAAGCCCAGT
TGAGCCAGAAGGAGCAGGCAGCTGAGCACTATAAGCTGCAGATGGAGAAAGCCAAAACACATTATGATGCCAAGAAGCAGCAGAACCAAG
AGCTGCAGGAGCAGCTGCGGAGCCTGGAGCAGCTGCAGAAGGAAAACAAAGAGCTGCGAGCTGAAGCTGAACGGCTGGGCCATGAGCTAC
AGCAGGCTGGGCTGAAGACCAAGGAGGCTGAACAGACCTGCCGCCACCTTACTGCCCAGGTGCGCAGCCTGGAGGCACAGGTTGCCCATG
CAGACCAGCAGCTTCGAGACCTGGGCAAATTCCAGGTGGCAACTGATGCTTTAAAGAGCCGTGAGCCCCAGGCTAAGCCCCAGCTGGACT
TGAGTATTGACAGCCTGGATCTGAGCTGCGAGGAGGGGACCCCACTCAGTATCACCAGCAAGCTGCCTCGTACCCAGCCAGACGGCACCA
GCGTCCCTGGAGAACCAGCCTCACCTATCTCCCAGCGCCTGCCCCCCAAGGTAGAATCCCTGGAGAGTCTCTACTTCACTCCCATCCCTG
CTCGGAGTCAGGCCCCCCTGGAGAGCAGCCTGGACTCCCTGGGAGACGTCTTCCTGGACTCGGGTCGTAAGACCCGCTCCGCTCGTCGGC
GCACCACGCAGATCATCAACATCACCATGACCAAGAAGCTAGATGTGGAAGAGCCAGACAGCGCCAACTCATCGTTCTACAGCACGCGGT
CTGCTCCTGCTTCCCAGGCTAGCCTGCGAGCCACCTCCTCTACTCAGTCTCTAGCTCGCCTGGGTTCTCCCGATTATGGCAACTCAGCCC
TGCTCAGCTTGCCTGGCTACCGCCCCACCACTCGCAGTTCTGCTCGTCGTTCCCAGGCCGGGGTGTCCAGTGGGGCCCCTCCAGCCATTG
AGACCCAGAGCAGCAGTTCTGAAGAGATAGTGCCCAGCCCTCCCTCGCCACCCCCTCTACCCCGCATCTACAAGCCTTGCTTTGTCTGTC
AGGACAAGTCCTCAGGCTACCACTATGGGGTCAGCGCCTGTGAGGGCTGCAAGGGCTTCTTCCGCCGCAGCATCCAGAAGAACATGGTGT
ACACGTGTCACCGGGACAAGAACTGCATCATCAACAAGGTGACCCGGAACCGCTGCCAGTACTGCCGACTGCAGAAGTGCTTTGAAGTGG
GCATGTCCAAGGAGTCTGTGAGAAACGACCGAAACAAGAAGAAGAAGGAGGTGCCCAAGCCCGAGTGCTCTGAGAGCTACACGCTGACGC
CGGAGGTGGGGGAGCTCATTGAGAAGGTGCGCAAAGCGCACCAGGAAACCTTCCCTGCCCTCTGCCAGCTGGGCAAATACACTACGAACA
ACAGCTCAGAACAACGTGTCTCTCTGGACATTGACCTCTGGGACAAGTTCAGTGAACTCTCCACCAAGTGCATCATTAAGACTGTGGAGT
TCGCCAAGCAGCTGCCCGGCTTCACCACCCTCACCATCGCCGACCAGATCACCCTCCTCAAGGCTGCCTGCCTGGACATCCTGATCCTGC
GGATCTGCACGCGGTACACGCCCGAGCAGGACACCATGACCTTCTCGGACGGGCTGACCCTGAACCGGACCCAGATGCACAACGCTGGCT
TCGGCCCCCTCACCGACCTGGTCTTTGCCTTCGCCAACCAGCTGCTGCCCCTGGAGATGGATGATGCGGAGACGGGGCTGCTCAGCGCCA
TCTGCCTCATCTGCGGAGACCGCCAGGACCTGGAGCAGCCGGACCGGGTGGACATGCTGCAGGAGCCGCTGCTGGAGGCGCTAAAGGTCT
ACGTGCGGAAGCGGAGGCCCAGCCGCCCCCACATGTTCCCCAAGATGCTAATGAAGATTACTGACCTGCGAAGCATCAGCGCCAAGGGGG
CTGAGCGGGTGATCACGCTGAAGATGGAGATCCCGGGCTCCATGCCGCCTCTCATCCAGGAAATGTTGGAGAACTCAGAGGGCCTGGACA
CTCTGAGCGGACAGCCGGGGGGTGGGGGGCGGGACGGGGGTGGCCTGGCCCCCCCGCCAGGCAGCTGTAGCCCCAGCCTCAGCCCCAGCT
CCAACAGAAGCAGCCCGGCCACCCACTCCCCGTGACCGCCCACGCCACATGGACACAGCCCTCGCCCTCCGCCCCGGCTTTTCTCTGCCT

>60916_60916_4_NUMA1-RARA_NUMA1_chr11_71717080_ENST00000393695_RARA_chr17_38504567_ENST00000394089_length(amino acids)=2306AA_BP=1903
MSGITKMTLHATRGAALLSWVNSLHVADPVEAVLQLQDCSIFIKIIDRIHGTEEGQQILKQPVSERLDFVCSFLQKNRKHPSSPECLVSA
QKVLEGSELELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGLNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQ
AKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALL
NEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQE
WLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERG
QQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQ
LAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQL
QVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVT
KGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECE
QLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVR
AQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL
RAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEA
AQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSAL
ETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRL
VMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALS
TLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYA
EQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQ
RFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQM
EKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVAT
DALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPGEPASPISQRLPPKVESLESLYFTPIPARSQAPLESSLDSLG
DVFLDSGRKTRSARRRTTQIINITMTKKLDVEEPDSANSSFYSTRSAPASQASLRATSSTQSLARLGSPDYGNSALLSLPGYRPTTRSSA
RRSQAGVSSGAPPAIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVT
RNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWD
KFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQL
LPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NUMA1-RARA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NUMA1-RARA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NUMA1-RARA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource