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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NUMB-TSHR (FusionGDB2 ID:60951)

Fusion Gene Summary for NUMB-TSHR

check button Fusion gene summary
Fusion gene informationFusion gene name: NUMB-TSHR
Fusion gene ID: 60951
HgeneTgene
Gene symbol

NUMB

TSHR

Gene ID

8650

7253

Gene nameNUMB endocytic adaptor proteinthyroid stimulating hormone receptor
SynonymsC14orf41|S171|c14_5527CHNG1|LGR3|hTSHR-I
Cytomap

14q24.2-q24.3

14q31.1

Type of geneprotein-codingprotein-coding
Descriptionprotein numb homologh-Numbnumb homologthyrotropin receptorTSH receptorseven transmembrane helix receptorthyrotropin receptor-I, hTSHR-I
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000355058, ENST00000356296, 
ENST00000359560, ENST00000454166, 
ENST00000535282, ENST00000544991, 
ENST00000554521, ENST00000554546, 
ENST00000555238, ENST00000555394, 
ENST00000555738, ENST00000557597, 
ENST00000559312, ENST00000560335, 
ENST00000556600, ENST00000556772, 
ENST00000557096, ENST00000298171, 
ENST00000342443, ENST00000541158, 
ENST00000554263, ENST00000554435, 
Fusion gene scores* DoF score24 X 15 X 9=32408 X 7 X 7=392
# samples 269
** MAII scorelog2(26/3240*10)=-3.63941028474353
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/392*10)=-2.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NUMB [Title/Abstract] AND TSHR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNUMB(73822334)-TSHR(81528492), # samples:2
Anticipated loss of major functional domain due to fusion event.NUMB-TSHR seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
NUMB-TSHR seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
NUMB-TSHR seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
NUMB-TSHR seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NUMB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TSHR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-WE-A8ZX-06ANUMBchr14

73822334

-TSHRchr14

81528492

+


Top

Fusion Gene ORF analysis for NUMB-TSHR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000355058ENST00000557096NUMBchr14

73822334

-TSHRchr14

81528492

+
5CDS-intronENST00000356296ENST00000557096NUMBchr14

73822334

-TSHRchr14

81528492

+
5CDS-intronENST00000359560ENST00000557096NUMBchr14

73822334

-TSHRchr14

81528492

+
5CDS-intronENST00000454166ENST00000557096NUMBchr14

73822334

-TSHRchr14

81528492

+
5CDS-intronENST00000535282ENST00000557096NUMBchr14

73822334

-TSHRchr14

81528492

+
5CDS-intronENST00000544991ENST00000557096NUMBchr14

73822334

-TSHRchr14

81528492

+
5CDS-intronENST00000554521ENST00000557096NUMBchr14

73822334

-TSHRchr14

81528492

+
5CDS-intronENST00000554546ENST00000557096NUMBchr14

73822334

-TSHRchr14

81528492

+
5CDS-intronENST00000555238ENST00000557096NUMBchr14

73822334

-TSHRchr14

81528492

+
5CDS-intronENST00000555394ENST00000557096NUMBchr14

73822334

-TSHRchr14

81528492

+
5CDS-intronENST00000555738ENST00000557096NUMBchr14

73822334

-TSHRchr14

81528492

+
5CDS-intronENST00000557597ENST00000557096NUMBchr14

73822334

-TSHRchr14

81528492

+
5CDS-intronENST00000559312ENST00000557096NUMBchr14

73822334

-TSHRchr14

81528492

+
5CDS-intronENST00000560335ENST00000557096NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000454166ENST00000298171NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000454166ENST00000342443NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000454166ENST00000541158NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000454166ENST00000554263NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000454166ENST00000554435NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000544991ENST00000298171NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000544991ENST00000342443NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000544991ENST00000541158NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000544991ENST00000554263NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000544991ENST00000554435NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000554521ENST00000298171NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000554521ENST00000342443NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000554521ENST00000541158NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000554521ENST00000554263NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000554521ENST00000554435NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000554546ENST00000298171NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000554546ENST00000342443NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000554546ENST00000541158NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000554546ENST00000554263NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000554546ENST00000554435NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000555238ENST00000298171NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000555238ENST00000342443NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000555238ENST00000541158NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000555238ENST00000554263NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000555238ENST00000554435NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000555394ENST00000298171NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000555394ENST00000342443NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000555394ENST00000541158NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000555394ENST00000554263NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000555394ENST00000554435NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000555738ENST00000298171NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000555738ENST00000342443NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000555738ENST00000541158NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000555738ENST00000554263NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000555738ENST00000554435NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000557597ENST00000298171NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000557597ENST00000342443NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000557597ENST00000541158NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000557597ENST00000554263NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000557597ENST00000554435NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000559312ENST00000298171NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000559312ENST00000342443NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000559312ENST00000541158NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000559312ENST00000554263NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000559312ENST00000554435NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000560335ENST00000298171NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000560335ENST00000342443NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000560335ENST00000541158NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000560335ENST00000554263NUMBchr14

73822334

-TSHRchr14

81528492

+
Frame-shiftENST00000560335ENST00000554435NUMBchr14

73822334

-TSHRchr14

81528492

+
In-frameENST00000355058ENST00000298171NUMBchr14

73822334

-TSHRchr14

81528492

+
In-frameENST00000355058ENST00000342443NUMBchr14

73822334

-TSHRchr14

81528492

+
In-frameENST00000355058ENST00000541158NUMBchr14

73822334

-TSHRchr14

81528492

+
In-frameENST00000355058ENST00000554263NUMBchr14

73822334

-TSHRchr14

81528492

+
In-frameENST00000355058ENST00000554435NUMBchr14

73822334

-TSHRchr14

81528492

+
In-frameENST00000356296ENST00000298171NUMBchr14

73822334

-TSHRchr14

81528492

+
In-frameENST00000356296ENST00000342443NUMBchr14

73822334

-TSHRchr14

81528492

+
In-frameENST00000356296ENST00000541158NUMBchr14

73822334

-TSHRchr14

81528492

+
In-frameENST00000356296ENST00000554263NUMBchr14

73822334

-TSHRchr14

81528492

+
In-frameENST00000356296ENST00000554435NUMBchr14

73822334

-TSHRchr14

81528492

+
In-frameENST00000359560ENST00000298171NUMBchr14

73822334

-TSHRchr14

81528492

+
In-frameENST00000359560ENST00000342443NUMBchr14

73822334

-TSHRchr14

81528492

+
In-frameENST00000359560ENST00000541158NUMBchr14

73822334

-TSHRchr14

81528492

+
In-frameENST00000359560ENST00000554263NUMBchr14

73822334

-TSHRchr14

81528492

+
In-frameENST00000359560ENST00000554435NUMBchr14

73822334

-TSHRchr14

81528492

+
In-frameENST00000535282ENST00000298171NUMBchr14

73822334

-TSHRchr14

81528492

+
In-frameENST00000535282ENST00000342443NUMBchr14

73822334

-TSHRchr14

81528492

+
In-frameENST00000535282ENST00000541158NUMBchr14

73822334

-TSHRchr14

81528492

+
In-frameENST00000535282ENST00000554263NUMBchr14

73822334

-TSHRchr14

81528492

+
In-frameENST00000535282ENST00000554435NUMBchr14

73822334

-TSHRchr14

81528492

+
intron-3CDSENST00000556600ENST00000298171NUMBchr14

73822334

-TSHRchr14

81528492

+
intron-3CDSENST00000556600ENST00000342443NUMBchr14

73822334

-TSHRchr14

81528492

+
intron-3CDSENST00000556600ENST00000541158NUMBchr14

73822334

-TSHRchr14

81528492

+
intron-3CDSENST00000556600ENST00000554263NUMBchr14

73822334

-TSHRchr14

81528492

+
intron-3CDSENST00000556600ENST00000554435NUMBchr14

73822334

-TSHRchr14

81528492

+
intron-3CDSENST00000556772ENST00000298171NUMBchr14

73822334

-TSHRchr14

81528492

+
intron-3CDSENST00000556772ENST00000342443NUMBchr14

73822334

-TSHRchr14

81528492

+
intron-3CDSENST00000556772ENST00000541158NUMBchr14

73822334

-TSHRchr14

81528492

+
intron-3CDSENST00000556772ENST00000554263NUMBchr14

73822334

-TSHRchr14

81528492

+
intron-3CDSENST00000556772ENST00000554435NUMBchr14

73822334

-TSHRchr14

81528492

+
intron-intronENST00000556600ENST00000557096NUMBchr14

73822334

-TSHRchr14

81528492

+
intron-intronENST00000556772ENST00000557096NUMBchr14

73822334

-TSHRchr14

81528492

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356296NUMBchr1473822334-ENST00000541158TSHRchr1481528492+44794053162529737
ENST00000356296NUMBchr1473822334-ENST00000342443TSHRchr1481528492+1266405316996226
ENST00000356296NUMBchr1473822334-ENST00000298171TSHRchr1481528492+44794053162529737
ENST00000356296NUMBchr1473822334-ENST00000554263TSHRchr1481528492+1393405316930204
ENST00000356296NUMBchr1473822334-ENST00000554435TSHRchr1481528492+12984053161059247
ENST00000355058NUMBchr1473822334-ENST00000541158TSHRchr1481528492+44794053162529737
ENST00000355058NUMBchr1473822334-ENST00000342443TSHRchr1481528492+1266405316996226
ENST00000355058NUMBchr1473822334-ENST00000298171TSHRchr1481528492+44794053162529737
ENST00000355058NUMBchr1473822334-ENST00000554263TSHRchr1481528492+1393405316930204
ENST00000355058NUMBchr1473822334-ENST00000554435TSHRchr1481528492+12984053161059247
ENST00000359560NUMBchr1473822334-ENST00000541158TSHRchr1481528492+44794053162529737
ENST00000359560NUMBchr1473822334-ENST00000342443TSHRchr1481528492+1266405316996226
ENST00000359560NUMBchr1473822334-ENST00000298171TSHRchr1481528492+44794053162529737
ENST00000359560NUMBchr1473822334-ENST00000554263TSHRchr1481528492+1393405316930204
ENST00000359560NUMBchr1473822334-ENST00000554435TSHRchr1481528492+12984053161059247
ENST00000535282NUMBchr1473822334-ENST00000541158TSHRchr1481528492+44013272382451737
ENST00000535282NUMBchr1473822334-ENST00000342443TSHRchr1481528492+1188327238918226
ENST00000535282NUMBchr1473822334-ENST00000298171TSHRchr1481528492+44013272382451737
ENST00000535282NUMBchr1473822334-ENST00000554263TSHRchr1481528492+1315327238852204
ENST00000535282NUMBchr1473822334-ENST00000554435TSHRchr1481528492+1220327238981247

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356296ENST00000541158NUMBchr1473822334-TSHRchr1481528492+0.001536440.99846363
ENST00000356296ENST00000342443NUMBchr1473822334-TSHRchr1481528492+0.0031371270.9968629
ENST00000356296ENST00000298171NUMBchr1473822334-TSHRchr1481528492+0.001536440.99846363
ENST00000356296ENST00000554263NUMBchr1473822334-TSHRchr1481528492+0.0039854960.9960145
ENST00000356296ENST00000554435NUMBchr1473822334-TSHRchr1481528492+0.0070025420.9929974
ENST00000355058ENST00000541158NUMBchr1473822334-TSHRchr1481528492+0.001536440.99846363
ENST00000355058ENST00000342443NUMBchr1473822334-TSHRchr1481528492+0.0031371270.9968629
ENST00000355058ENST00000298171NUMBchr1473822334-TSHRchr1481528492+0.001536440.99846363
ENST00000355058ENST00000554263NUMBchr1473822334-TSHRchr1481528492+0.0039854960.9960145
ENST00000355058ENST00000554435NUMBchr1473822334-TSHRchr1481528492+0.0070025420.9929974
ENST00000359560ENST00000541158NUMBchr1473822334-TSHRchr1481528492+0.001536440.99846363
ENST00000359560ENST00000342443NUMBchr1473822334-TSHRchr1481528492+0.0031371270.9968629
ENST00000359560ENST00000298171NUMBchr1473822334-TSHRchr1481528492+0.001536440.99846363
ENST00000359560ENST00000554263NUMBchr1473822334-TSHRchr1481528492+0.0039854960.9960145
ENST00000359560ENST00000554435NUMBchr1473822334-TSHRchr1481528492+0.0070025420.9929974
ENST00000535282ENST00000541158NUMBchr1473822334-TSHRchr1481528492+0.0014453280.99855465
ENST00000535282ENST00000342443NUMBchr1473822334-TSHRchr1481528492+0.001957270.9980427
ENST00000535282ENST00000298171NUMBchr1473822334-TSHRchr1481528492+0.0014453280.99855465
ENST00000535282ENST00000554263NUMBchr1473822334-TSHRchr1481528492+0.0029928190.9970072
ENST00000535282ENST00000554435NUMBchr1473822334-TSHRchr1481528492+0.0047381120.9952619

Top

Fusion Genomic Features for NUMB-TSHR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NUMBchr1473822333-TSHRchr1481528491+3.89E-081
NUMBchr1473822333-TSHRchr1481528491+3.89E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NUMB-TSHR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:73822334/chr14:81528492)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

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* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTSHRchr14:73822334chr14:81528492ENST0000034244309762_76456254.0MotifNote=PDZ-binding
TgeneTSHRchr14:73822334chr14:81528492ENST0000055443509762_76456275.0MotifNote=PDZ-binding
TgeneTSHRchr14:73822334chr14:81528492ENST0000034244309100_12456254.0RepeatNote=LRR 1
TgeneTSHRchr14:73822334chr14:81528492ENST0000034244309125_15056254.0RepeatNote=LRR 2
TgeneTSHRchr14:73822334chr14:81528492ENST0000034244309152_17456254.0RepeatNote=LRR 3
TgeneTSHRchr14:73822334chr14:81528492ENST0000034244309176_19956254.0RepeatNote=LRR 4
TgeneTSHRchr14:73822334chr14:81528492ENST0000034244309200_22356254.0RepeatNote=LRR 5
TgeneTSHRchr14:73822334chr14:81528492ENST0000034244309227_24856254.0RepeatNote=LRR 6
TgeneTSHRchr14:73822334chr14:81528492ENST0000034244309250_27156254.0RepeatNote=LRR 7
TgeneTSHRchr14:73822334chr14:81528492ENST0000055443509100_12456275.0RepeatNote=LRR 1
TgeneTSHRchr14:73822334chr14:81528492ENST0000055443509125_15056275.0RepeatNote=LRR 2
TgeneTSHRchr14:73822334chr14:81528492ENST0000055443509152_17456275.0RepeatNote=LRR 3
TgeneTSHRchr14:73822334chr14:81528492ENST0000055443509176_19956275.0RepeatNote=LRR 4
TgeneTSHRchr14:73822334chr14:81528492ENST0000055443509200_22356275.0RepeatNote=LRR 5
TgeneTSHRchr14:73822334chr14:81528492ENST0000055443509227_24856275.0RepeatNote=LRR 6
TgeneTSHRchr14:73822334chr14:81528492ENST0000055443509250_27156275.0RepeatNote=LRR 7
TgeneTSHRchr14:73822334chr14:81528492ENST0000034244309442_45056254.0Topological domainCytoplasmic
TgeneTSHRchr14:73822334chr14:81528492ENST0000034244309474_49456254.0Topological domainExtracellular
TgeneTSHRchr14:73822334chr14:81528492ENST0000034244309518_53756254.0Topological domainCytoplasmic
TgeneTSHRchr14:73822334chr14:81528492ENST0000034244309561_58056254.0Topological domainExtracellular
TgeneTSHRchr14:73822334chr14:81528492ENST0000034244309603_62556254.0Topological domainCytoplasmic
TgeneTSHRchr14:73822334chr14:81528492ENST0000034244309650_66056254.0Topological domainExtracellular
TgeneTSHRchr14:73822334chr14:81528492ENST0000034244309683_76456254.0Topological domainCytoplasmic
TgeneTSHRchr14:73822334chr14:81528492ENST0000055443509442_45056275.0Topological domainCytoplasmic
TgeneTSHRchr14:73822334chr14:81528492ENST0000055443509474_49456275.0Topological domainExtracellular
TgeneTSHRchr14:73822334chr14:81528492ENST0000055443509518_53756275.0Topological domainCytoplasmic
TgeneTSHRchr14:73822334chr14:81528492ENST0000055443509561_58056275.0Topological domainExtracellular
TgeneTSHRchr14:73822334chr14:81528492ENST0000055443509603_62556275.0Topological domainCytoplasmic
TgeneTSHRchr14:73822334chr14:81528492ENST0000055443509650_66056275.0Topological domainExtracellular
TgeneTSHRchr14:73822334chr14:81528492ENST0000055443509683_76456275.0Topological domainCytoplasmic
TgeneTSHRchr14:73822334chr14:81528492ENST0000034244309414_44156254.0TransmembraneHelical%3B Name%3D1
TgeneTSHRchr14:73822334chr14:81528492ENST0000034244309451_47356254.0TransmembraneHelical%3B Name%3D2
TgeneTSHRchr14:73822334chr14:81528492ENST0000034244309495_51756254.0TransmembraneHelical%3B Name%3D3
TgeneTSHRchr14:73822334chr14:81528492ENST0000034244309538_56056254.0TransmembraneHelical%3B Name%3D4
TgeneTSHRchr14:73822334chr14:81528492ENST0000034244309581_60256254.0TransmembraneHelical%3B Name%3D5
TgeneTSHRchr14:73822334chr14:81528492ENST0000034244309626_64956254.0TransmembraneHelical%3B Name%3D6
TgeneTSHRchr14:73822334chr14:81528492ENST0000034244309661_68256254.0TransmembraneHelical%3B Name%3D7
TgeneTSHRchr14:73822334chr14:81528492ENST0000055443509414_44156275.0TransmembraneHelical%3B Name%3D1
TgeneTSHRchr14:73822334chr14:81528492ENST0000055443509451_47356275.0TransmembraneHelical%3B Name%3D2
TgeneTSHRchr14:73822334chr14:81528492ENST0000055443509495_51756275.0TransmembraneHelical%3B Name%3D3
TgeneTSHRchr14:73822334chr14:81528492ENST0000055443509538_56056275.0TransmembraneHelical%3B Name%3D4
TgeneTSHRchr14:73822334chr14:81528492ENST0000055443509581_60256275.0TransmembraneHelical%3B Name%3D5
TgeneTSHRchr14:73822334chr14:81528492ENST0000055443509626_64956275.0TransmembraneHelical%3B Name%3D6
TgeneTSHRchr14:73822334chr14:81528492ENST0000055443509661_68256275.0TransmembraneHelical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNUMBchr14:73822334chr14:81528492ENST00000355058-41333_19342652.0DomainPID
HgeneNUMBchr14:73822334chr14:81528492ENST00000356296-41233_19342604.0DomainPID
HgeneNUMBchr14:73822334chr14:81528492ENST00000359560-41233_19342641.0DomainPID
HgeneNUMBchr14:73822334chr14:81528492ENST00000454166-1833_19342506.0DomainPID
HgeneNUMBchr14:73822334chr14:81528492ENST00000535282-31133_19342641.0DomainPID
HgeneNUMBchr14:73822334chr14:81528492ENST00000554546-41133_19342593.0DomainPID
HgeneNUMBchr14:73822334chr14:81528492ENST00000555238-41333_19342652.0DomainPID
HgeneNUMBchr14:73822334chr14:81528492ENST00000555394-41233_19342604.0DomainPID
HgeneNUMBchr14:73822334chr14:81528492ENST00000555738-2833_19342495.0DomainPID
HgeneNUMBchr14:73822334chr14:81528492ENST00000557597-41233_19342641.0DomainPID
HgeneNUMBchr14:73822334chr14:81528492ENST00000560335-2933_19342506.0DomainPID
TgeneTSHRchr14:73822334chr14:81528492ENST000003424430921_41356254.0Topological domainExtracellular
TgeneTSHRchr14:73822334chr14:81528492ENST000005544350921_41356275.0Topological domainExtracellular


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Fusion Gene Sequence for NUMB-TSHR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>60951_60951_1_NUMB-TSHR_NUMB_chr14_73822334_ENST00000355058_TSHR_chr14_81528492_ENST00000298171_length(transcript)=4479nt_BP=405nt
GCTTGAGTTGGTCGGGGGCAGCGGCAGCTGAGCTGGGATGGGAGACCCAACTGGCCTGGCCGCTCCGGCTCTGAGGATCCCTAAGGGACC
AGGAAAGAAGTCCTCGAGGAGTGGCTCGCGTTTGAGACCGGGATTTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTGCCAGTGCAGCCA
CTGTTACAATTCAAGATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCACTTAGGACAAGCTGTA
AAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACA
GATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGGAAGCTTATTGAGACTCACCTGAGAACTATTCCAAGTCATGCATT
TTCTAATCTGCCCAATATTTCCAGAATCTACGTATCTATAGATGTGACTCTGCAGCAGCTGGAATCACACTCCTTCTACAATTTGAGTAA
AGTGACTCACATAGAAATTCGGAATACCAGGAACTTAACTTACATAGACCCTGATGCCCTCAAAGAGCTCCCCCTCCTAAAGTTCCTTGG
CATTTTCAACACTGGACTTAAAATGTTCCCTGACCTGACCAAAGTTTATTCCACTGATATATTCTTTATACTTGAAATTACAGACAACCC
TTACATGACGTCAATCCCTGTGAATGCTTTTCAGGGACTATGCAATGAAACCTTGACACTGAAGCTGTACAACAATGGCTTTACTTCAGT
CCAAGGATATGCTTTCAATGGGACAAAGCTGGATGCTGTTTACCTAAACAAGAATAAATACCTGACAGTTATTGACAAAGATGCATTTGG
AGGAGTATACAGTGGACCAAGCTTGCTGGACGTGTCTCAAACCAGTGTCACTGCCCTTCCATCCAAAGGCCTGGAGCACCTGAAGGAACT
GATAGCAAGAAACACCTGGACTCTTAAGAAACTTCCACTTTCCTTGAGTTTCCTTCACCTCACACGGGCTGACCTTTCTTACCCAAGCCA
CTGCTGTGCTTTTAAGAATCAGAAGAAAATCAGAGGAATCCTTGAGTCCTTGATGTGTAATGAGAGCAGTATGCAGAGCTTGCGCCAGAG
AAAATCTGTGAATGCCTTGAATAGCCCCCTCCACCAGGAATATGAAGAGAATCTGGGTGACAGCATTGTTGGGTACAAGGAAAAGTCCAA
GTTCCAGGATACTCATAACAACGCTCATTATTACGTCTTCTTTGAAGAACAAGAGGATGAGATCATTGGTTTTGGCCAGGAGCTCAAAAA
CCCCCAGGAAGAGACTCTACAAGCTTTTGACAGCCATTATGACTACACCATATGTGGGGACAGTGAAGACATGGTGTGTACCCCCAAGTC
CGATGAGTTCAACCCGTGTGAAGACATAATGGGCTACAAGTTCCTGAGAATTGTGGTGTGGTTCGTTAGTCTGCTGGCTCTCCTGGGCAA
TGTCTTTGTCCTGCTTATTCTCCTCACCAGCCACTACAAACTGAACGTCCCCCGCTTTCTCATGTGCAACCTGGCCTTTGCGGATTTCTG
CATGGGGATGTACCTGCTCCTCATCGCCTCTGTAGACCTCTACACTCACTCTGAGTACTACAACCATGCCATCGACTGGCAGACAGGCCC
TGGGTGCAACACGGCTGGTTTCTTCACTGTCTTTGCAAGCGAGTTATCGGTGTATACGCTGACGGTCATCACCCTGGAGCGCTGGTATGC
CATCACCTTCGCCATGCGCCTGGACCGGAAGATCCGCCTCAGGCACGCATGTGCCATCATGGTTGGGGGCTGGGTTTGCTGCTTCCTTCT
CGCCCTGCTTCCTTTGGTGGGAATAAGTAGCTATGCCAAAGTCAGTATCTGCCTGCCCATGGACACCGAGACCCCTCTTGCTCTGGCATA
TATTGTTTTTGTTCTGACGCTCAACATAGTTGCCTTCGTCATCGTCTGCTGCTGTTATGTGAAGATCTACATCACAGTCCGAAATCCGCA
GTACAACCCAGGGGACAAAGATACCAAAATTGCCAAGAGGATGGCTGTGTTGATCTTCACCGACTTCATATGCATGGCCCCAATCTCATT
CTATGCTCTGTCAGCAATTCTGAACAAGCCTCTCATCACTGTTAGCAACTCCAAAATCTTGCTGGTACTCTTCTATCCACTTAACTCCTG
TGCCAATCCATTCCTCTATGCTATTTTCACCAAGGCCTTCCAGAGGGATGTGTTCATCCTACTCAGCAAGTTTGGCATCTGTAAACGCCA
GGCTCAGGCATACCGGGGGCAGAGGGTTCCTCCAAAGAACAGCACTGATATTCAGGTTCAAAAGGTTACCCACGAGATGAGGCAGGGTCT
CCACAACATGGAAGATGTCTATGAACTGATTGAAAACTCCCATCTAACCCCAAAGAAGCAAGGCCAAATCTCAGAAGAGTATATGCAAAC
GGTTTTGTAAGTTAACACTACACTACTCACAATGGTAGGGGAACTTACAAAATAATAGTTTCTTGAATATGCATTCCAATCCCATGACAC
CCCCAACACATAGCTGCCCTCACTCTTGTGCAGGCGATGTTTCAATGTTTCATGGGGCAAGAGTTTATCTCTGGAGAGTGATTAGTATTA
ACCTAATCATTGCCCCCAAGAAGGAAGTTAGGCTACCAGCATATTTGAATGCCAGGTGAAATCAAAATAATCTACACTATCTAGAAGACT
TTCTTGATGCCAAGTCCAGAGATGTCATTGTGTAGGATGTTCAGTAAATATTAACTGAGCTATGTCAATATAGAGCTTCTCAGTTTTGTA
TAACATTTCATACTAAAGATTCAGCAAATGGAAAATGCTATTAATTTGGTTGGTGACCACAAGATAAAATCAGTCCCACGTTGGCTCAGT
TCAACTAGATGTTCCCTGATACAAAGAGAACTTGATTTCCTTAAAACTGAAAAGCCAAACACAGCTAGCTGTCATACAAGAAACAGCTAT
TATGAGACATGAAGGAGGGTAAGAATTAGCTTTAAGTTTTGTTTTGCTTTGTTTTGTTTTTTAACTCAACCTATTAATCATCTCTTCACA
AGAATCCACCTGATGTGACCAAGCTATTATGTGTTGCCTGGAAAAACTGGCAAGATTTCAGCTTATGTGGCCTAGCAAACTAAGAATTGC
TCTTCTTGGCCAGCCTCATAGCATAAAAGATGTGAACTCTAGGAAGTCTTTCTGAGTAGCAATAAGTGGGAATTATGGGCAGAGCACACT
CAATCCCCTGTTGATTAATAAAACAGGCTGGACACTAATTAACTATGGGACTTAAATCTGTAGAAATGAAGGAGTCCAATAGCTTCTTCC
AATTTTAAAACTCTAGTACATCCCTTTCCCTCAAATATATATTTCTAAGATAAAGAGAAAGAAGAGCACTAAGTAAGTAGAATCTGTTTT
TCCTATTTTGTAGGGCTGCTGACTCCTAGTCCTTGAAGCCTAGACACATGACCCAGGAAATTTTTCCTTTGTTTCACTTTTGATTATGAT
GTCTGAGCCAAAAATTCAATTAAGTAAACATACTCGCCTGGATCTGAATCATTCATTTAATTACTAGATCTACCCAGCTGTTATATCAGG
CCAAAAACAGATTCGTGTTTATATAAAAGAGTAAACGATGGTTGCAAATTTTGGCTATTTAGAGTTGCTACTTCACTATGAAGAGTCACT
TCAAAACACTTCGCTTGTCTTTAGGGATGATTTTTGCCATTTCCAGTCCACGGTATGATACTAAAGCTGTCAAGAGAGGTTTCTTCTTTT
CTGAAACTGCCAGCTCTTTCCAGCCCTGTTGATCACTGGACATAAAGCTTCTTTTCCCCAATAATTCTTCTTTACTTAAAATAGTCAGGA
TCTTTATCTACAGATGTACTCTCCAGGTTACCTGTGATGATAGCCCCCTAATGTCCTGCTAGAAAAGTCTCCAAGCAGAGATGACATTAC
TTCTGAATGCTCATAAACCACACCATGAAATAAAAGCTCTTTGTTGTTTTAAGATTGTGAAGTGTCGTTAATGGGTCCCCACAGATGGTC
CCTGCTGGACTCACCTGGAATCTCTCCACAGCCATACCCACTCATCACTATCATTGAGACCTGCACATCTTAATAGAAATATTATAAACA
TCGAAAATCATGACTTACCTAGAAGTTCGCTTGTAACTAATGAAATTAAACAAATGTGTTGCCTTTTGTCATGTGTTTCTCTCCTGTGAC
ATTTCAAAATATCACATCTTGATAAATAATGTGTTTCATCTTGAATAGCTGAACTAATTGCTTTGGAAACAGAGTCCTAGAAAAGTGACT

>60951_60951_1_NUMB-TSHR_NUMB_chr14_73822334_ENST00000355058_TSHR_chr14_81528492_ENST00000298171_length(amino acids)=737AA_BP=29
MFMFQRPVVHISGRQMKKAFAPENVASRLRKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYI
DPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYL
NKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILE
SLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDY
TICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYT
HSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVS
ICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVS
NSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHEMRQGLHNMEDVYELIENSHL

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>60951_60951_2_NUMB-TSHR_NUMB_chr14_73822334_ENST00000355058_TSHR_chr14_81528492_ENST00000342443_length(transcript)=1266nt_BP=405nt
GCTTGAGTTGGTCGGGGGCAGCGGCAGCTGAGCTGGGATGGGAGACCCAACTGGCCTGGCCGCTCCGGCTCTGAGGATCCCTAAGGGACC
AGGAAAGAAGTCCTCGAGGAGTGGCTCGCGTTTGAGACCGGGATTTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTGCCAGTGCAGCCA
CTGTTACAATTCAAGATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCACTTAGGACAAGCTGTA
AAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACA
GATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGGAAGCTTATTGAGACTCACCTGAGAACTATTCCAAGTCATGCATT
TTCTAATCTGCCCAATATTTCCAGAATCTACGTATCTATAGATGTGACTCTGCAGCAGCTGGAATCACACTCCTTCTACAATTTGAGTAA
AGTGACTCACATAGAAATTCGGAATACCAGGAACTTAACTTACATAGACCCTGATGCCCTCAAAGAGCTCCCCCTCCTAAAGTTCCTTGG
CATTTTCAACACTGGACTTAAAATGTTCCCTGACCTGACCAAAGTTTATTCCACTGATATATTCTTTATACTTGAAATTACAGACAACCC
TTACATGACGTCAATCCCTGTGAATGCTTTTCAGGGACTATGCAATGAAACCTTGACACTGAAGCTGTACAACAATGGCTTTACTTCAGT
CCAAGGATATGCTTTCAATGGGACAAAGCTGGATGCTGTTTACCTAAACAAGAATAAATACCTGACAGTTATTGACAAAGATGCATTTGG
AGGAGTATACAGTGGACCAAGCTTGCTGCTACCTCTTGGAAGAAAGTCCTTGTCCTTTGAGACTCAGAAGGCCCCACGCTCCAGTATGCC
ATCATGATGCCTGCTAAGGCAGCCACCTTGGTGTACATGCTCACAGAGGCTCTGTTCATGGAGCAGCTGCTGTTTGAAAAATTTTGAAAT
GCAAGATCCACAACTAGATGGAAGGCACTCTAGTCTTTGCAGAAAAAAATGTACCTGAATGTACATTGCACAATGCCTGGCACAAAGAAG
GAAGAATATAAATGATAGTTCGACTCGTCTGTGGAAGAACTTACAATCATGGGGAAAGATGGAATAAAAACATTTTTTAAACAGCATGAA

>60951_60951_2_NUMB-TSHR_NUMB_chr14_73822334_ENST00000355058_TSHR_chr14_81528492_ENST00000342443_length(amino acids)=226AA_BP=29
MFMFQRPVVHISGRQMKKAFAPENVASRLRKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYI
DPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYL

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>60951_60951_3_NUMB-TSHR_NUMB_chr14_73822334_ENST00000355058_TSHR_chr14_81528492_ENST00000541158_length(transcript)=4479nt_BP=405nt
GCTTGAGTTGGTCGGGGGCAGCGGCAGCTGAGCTGGGATGGGAGACCCAACTGGCCTGGCCGCTCCGGCTCTGAGGATCCCTAAGGGACC
AGGAAAGAAGTCCTCGAGGAGTGGCTCGCGTTTGAGACCGGGATTTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTGCCAGTGCAGCCA
CTGTTACAATTCAAGATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCACTTAGGACAAGCTGTA
AAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACA
GATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGGAAGCTTATTGAGACTCACCTGAGAACTATTCCAAGTCATGCATT
TTCTAATCTGCCCAATATTTCCAGAATCTACGTATCTATAGATGTGACTCTGCAGCAGCTGGAATCACACTCCTTCTACAATTTGAGTAA
AGTGACTCACATAGAAATTCGGAATACCAGGAACTTAACTTACATAGACCCTGATGCCCTCAAAGAGCTCCCCCTCCTAAAGTTCCTTGG
CATTTTCAACACTGGACTTAAAATGTTCCCTGACCTGACCAAAGTTTATTCCACTGATATATTCTTTATACTTGAAATTACAGACAACCC
TTACATGACGTCAATCCCTGTGAATGCTTTTCAGGGACTATGCAATGAAACCTTGACACTGAAGCTGTACAACAATGGCTTTACTTCAGT
CCAAGGATATGCTTTCAATGGGACAAAGCTGGATGCTGTTTACCTAAACAAGAATAAATACCTGACAGTTATTGACAAAGATGCATTTGG
AGGAGTATACAGTGGACCAAGCTTGCTGGACGTGTCTCAAACCAGTGTCACTGCCCTTCCATCCAAAGGCCTGGAGCACCTGAAGGAACT
GATAGCAAGAAACACCTGGACTCTTAAGAAACTTCCACTTTCCTTGAGTTTCCTTCACCTCACACGGGCTGACCTTTCTTACCCAAGCCA
CTGCTGTGCTTTTAAGAATCAGAAGAAAATCAGAGGAATCCTTGAGTCCTTGATGTGTAATGAGAGCAGTATGCAGAGCTTGCGCCAGAG
AAAATCTGTGAATGCCTTGAATAGCCCCCTCCACCAGGAATATGAAGAGAATCTGGGTGACAGCATTGTTGGGTACAAGGAAAAGTCCAA
GTTCCAGGATACTCATAACAACGCTCATTATTACGTCTTCTTTGAAGAACAAGAGGATGAGATCATTGGTTTTGGCCAGGAGCTCAAAAA
CCCCCAGGAAGAGACTCTACAAGCTTTTGACAGCCATTATGACTACACCATATGTGGGGACAGTGAAGACATGGTGTGTACCCCCAAGTC
CGATGAGTTCAACCCGTGTGAAGACATAATGGGCTACAAGTTCCTGAGAATTGTGGTGTGGTTCGTTAGTCTGCTGGCTCTCCTGGGCAA
TGTCTTTGTCCTGCTTATTCTCCTCACCAGCCACTACAAACTGAACGTCCCCCGCTTTCTCATGTGCAACCTGGCCTTTGCGGATTTCTG
CATGGGGATGTACCTGCTCCTCATCGCCTCTGTAGACCTCTACACTCACTCTGAGTACTACAACCATGCCATCGACTGGCAGACAGGCCC
TGGGTGCAACACGGCTGGTTTCTTCACTGTCTTTGCAAGCGAGTTATCGGTGTATACGCTGACGGTCATCACCCTGGAGCGCTGGTATGC
CATCACCTTCGCCATGCGCCTGGACCGGAAGATCCGCCTCAGGCACGCATGTGCCATCATGGTTGGGGGCTGGGTTTGCTGCTTCCTTCT
CGCCCTGCTTCCTTTGGTGGGAATAAGTAGCTATGCCAAAGTCAGTATCTGCCTGCCCATGGACACCGAGACCCCTCTTGCTCTGGCATA
TATTGTTTTTGTTCTGACGCTCAACATAGTTGCCTTCGTCATCGTCTGCTGCTGTTATGTGAAGATCTACATCACAGTCCGAAATCCGCA
GTACAACCCAGGGGACAAAGATACCAAAATTGCCAAGAGGATGGCTGTGTTGATCTTCACCGACTTCATATGCATGGCCCCAATCTCATT
CTATGCTCTGTCAGCAATTCTGAACAAGCCTCTCATCACTGTTAGCAACTCCAAAATCTTGCTGGTACTCTTCTATCCACTTAACTCCTG
TGCCAATCCATTCCTCTATGCTATTTTCACCAAGGCCTTCCAGAGGGATGTGTTCATCCTACTCAGCAAGTTTGGCATCTGTAAACGCCA
GGCTCAGGCATACCGGGGGCAGAGGGTTCCTCCAAAGAACAGCACTGATATTCAGGTTCAAAAGGTTACCCACGAGATGAGGCAGGGTCT
CCACAACATGGAAGATGTCTATGAACTGATTGAAAACTCCCATCTAACCCCAAAGAAGCAAGGCCAAATCTCAGAAGAGTATATGCAAAC
GGTTTTGTAAGTTAACACTACACTACTCACAATGGTAGGGGAACTTACAAAATAATAGTTTCTTGAATATGCATTCCAATCCCATGACAC
CCCCAACACATAGCTGCCCTCACTCTTGTGCAGGCGATGTTTCAATGTTTCATGGGGCAAGAGTTTATCTCTGGAGAGTGATTAGTATTA
ACCTAATCATTGCCCCCAAGAAGGAAGTTAGGCTACCAGCATATTTGAATGCCAGGTGAAATCAAAATAATCTACACTATCTAGAAGACT
TTCTTGATGCCAAGTCCAGAGATGTCATTGTGTAGGATGTTCAGTAAATATTAACTGAGCTATGTCAATATAGAGCTTCTCAGTTTTGTA
TAACATTTCATACTAAAGATTCAGCAAATGGAAAATGCTATTAATTTGGTTGGTGACCACAAGATAAAATCAGTCCCACGTTGGCTCAGT
TCAACTAGATGTTCCCTGATACAAAGAGAACTTGATTTCCTTAAAACTGAAAAGCCAAACACAGCTAGCTGTCATACAAGAAACAGCTAT
TATGAGACATGAAGGAGGGTAAGAATTAGCTTTAAGTTTTGTTTTGCTTTGTTTTGTTTTTTAACTCAACCTATTAATCATCTCTTCACA
AGAATCCACCTGATGTGACCAAGCTATTATGTGTTGCCTGGAAAAACTGGCAAGATTTCAGCTTATGTGGCCTAGCAAACTAAGAATTGC
TCTTCTTGGCCAGCCTCATAGCATAAAAGATGTGAACTCTAGGAAGTCTTTCTGAGTAGCAATAAGTGGGAATTATGGGCAGAGCACACT
CAATCCCCTGTTGATTAATAAAACAGGCTGGACACTAATTAACTATGGGACTTAAATCTGTAGAAATGAAGGAGTCCAATAGCTTCTTCC
AATTTTAAAACTCTAGTACATCCCTTTCCCTCAAATATATATTTCTAAGATAAAGAGAAAGAAGAGCACTAAGTAAGTAGAATCTGTTTT
TCCTATTTTGTAGGGCTGCTGACTCCTAGTCCTTGAAGCCTAGACACATGACCCAGGAAATTTTTCCTTTGTTTCACTTTTGATTATGAT
GTCTGAGCCAAAAATTCAATTAAGTAAACATACTCGCCTGGATCTGAATCATTCATTTAATTACTAGATCTACCCAGCTGTTATATCAGG
CCAAAAACAGATTCGTGTTTATATAAAAGAGTAAACGATGGTTGCAAATTTTGGCTATTTAGAGTTGCTACTTCACTATGAAGAGTCACT
TCAAAACACTTCGCTTGTCTTTAGGGATGATTTTTGCCATTTCCAGTCCACGGTATGATACTAAAGCTGTCAAGAGAGGTTTCTTCTTTT
CTGAAACTGCCAGCTCTTTCCAGCCCTGTTGATCACTGGACATAAAGCTTCTTTTCCCCAATAATTCTTCTTTACTTAAAATAGTCAGGA
TCTTTATCTACAGATGTACTCTCCAGGTTACCTGTGATGATAGCCCCCTAATGTCCTGCTAGAAAAGTCTCCAAGCAGAGATGACATTAC
TTCTGAATGCTCATAAACCACACCATGAAATAAAAGCTCTTTGTTGTTTTAAGATTGTGAAGTGTCGTTAATGGGTCCCCACAGATGGTC
CCTGCTGGACTCACCTGGAATCTCTCCACAGCCATACCCACTCATCACTATCATTGAGACCTGCACATCTTAATAGAAATATTATAAACA
TCGAAAATCATGACTTACCTAGAAGTTCGCTTGTAACTAATGAAATTAAACAAATGTGTTGCCTTTTGTCATGTGTTTCTCTCCTGTGAC
ATTTCAAAATATCACATCTTGATAAATAATGTGTTTCATCTTGAATAGCTGAACTAATTGCTTTGGAAACAGAGTCCTAGAAAAGTGACT

>60951_60951_3_NUMB-TSHR_NUMB_chr14_73822334_ENST00000355058_TSHR_chr14_81528492_ENST00000541158_length(amino acids)=737AA_BP=29
MFMFQRPVVHISGRQMKKAFAPENVASRLRKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYI
DPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYL
NKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILE
SLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDY
TICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYT
HSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVS
ICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVS
NSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHEMRQGLHNMEDVYELIENSHL

--------------------------------------------------------------
>60951_60951_4_NUMB-TSHR_NUMB_chr14_73822334_ENST00000355058_TSHR_chr14_81528492_ENST00000554263_length(transcript)=1393nt_BP=405nt
GCTTGAGTTGGTCGGGGGCAGCGGCAGCTGAGCTGGGATGGGAGACCCAACTGGCCTGGCCGCTCCGGCTCTGAGGATCCCTAAGGGACC
AGGAAAGAAGTCCTCGAGGAGTGGCTCGCGTTTGAGACCGGGATTTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTGCCAGTGCAGCCA
CTGTTACAATTCAAGATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCACTTAGGACAAGCTGTA
AAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACA
GATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGGAAGCTTATTGAGACTCACCTGAGAACTATTCCAAGTCATGCATT
TTCTAATCTGCCCAATATTTCCAGAATCTACGTATCTATAGATGTGACTCTGCAGCAGCTGGAATCACACTCCTTCTACAATTTGAGTAA
AGTGACTCACATAGAAATTCGGAATACCAGGAACTTAACTTACATAGACCCTGATGCCCTCAAAGAGCTCCCCCTCCTAAAGTTCCTTGG
CATTTTCAACACTGGACTTAAAATGTTCCCTGACCTGACCAAAGTTTATTCCACTGATATATTCTTTATACTTGAAATTACAGACAACCC
TTACATGACGTCAATCCCTGTGAATGCTTTTCAGGGACTATGCAATGAAACCTTGACACTGAAGCTGTACAACAATGGCTTTACTTCAGT
CCAAGGATATGCTTTCAATGGGACAAAGCTGGATGCTGTTTACCTAAACAAGAATAAATACCTGACAGTTATTGACAAAGATGCATTTGG
AGGAGTATACAGTGGACCAAGCTTGCTGTGAGTAAGACATACAAAAGAATATTTTAGTCTTTTTTTTTCTTTTTTTTTTTTTGGAATAAA
TGGAGACATTAAGGGGAGAATCTTATGTTCAAGGGTAGAAAATGTTGCTGTCTCGGGTAAAGGCTTCTGCAAGTCCCTCTTTTCCTGGCT
GTATAGGCTACCTCTTGGAAGAAAGTCCTTGTCCTTTGAGACTCAGAAGGCCCCACGCTCCAGTATGCCATCATGATGCCTGCTAAGGCA
GCCACCTTGGTGTACATGCTCACAGAGGCTCTGTTCATGGAGCAGCTGCTGTTTGAAAAATTTTGAAATGCAAGATCCACAACTAGATGG
AAGGCACTCTAGTCTTTGCAGAAAAAAATGTACCTGAATGTACATTGCACAATGCCTGGCACAAAGAAGGAAGAATATAAATGATAGTTC

>60951_60951_4_NUMB-TSHR_NUMB_chr14_73822334_ENST00000355058_TSHR_chr14_81528492_ENST00000554263_length(amino acids)=204AA_BP=29
MFMFQRPVVHISGRQMKKAFAPENVASRLRKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYI
DPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYL

--------------------------------------------------------------
>60951_60951_5_NUMB-TSHR_NUMB_chr14_73822334_ENST00000355058_TSHR_chr14_81528492_ENST00000554435_length(transcript)=1298nt_BP=405nt
GCTTGAGTTGGTCGGGGGCAGCGGCAGCTGAGCTGGGATGGGAGACCCAACTGGCCTGGCCGCTCCGGCTCTGAGGATCCCTAAGGGACC
AGGAAAGAAGTCCTCGAGGAGTGGCTCGCGTTTGAGACCGGGATTTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTGCCAGTGCAGCCA
CTGTTACAATTCAAGATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCACTTAGGACAAGCTGTA
AAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACA
GATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGGAAGCTTATTGAGACTCACCTGAGAACTATTCCAAGTCATGCATT
TTCTAATCTGCCCAATATTTCCAGAATCTACGTATCTATAGATGTGACTCTGCAGCAGCTGGAATCACACTCCTTCTACAATTTGAGTAA
AGTGACTCACATAGAAATTCGGAATACCAGGAACTTAACTTACATAGACCCTGATGCCCTCAAAGAGCTCCCCCTCCTAAAGTTCCTTGG
CATTTTCAACACTGGACTTAAAATGTTCCCTGACCTGACCAAAGTTTATTCCACTGATATATTCTTTATACTTGAAATTACAGACAACCC
TTACATGACGTCAATCCCTGTGAATGCTTTTCAGGGACTATGCAATGAAACCTTGACACTGAAGCTGTACAACAATGGCTTTACTTCAGT
CCAAGGATATGCTTTCAATGGGACAAAGCTGGATGCTGTTTACCTAAACAAGAATAAATACCTGACAGTTATTGACAAAGATGCATTTGG
AGGAGTATACAGTGGACCAAGCTTGCTGGTAGAAAATGTTGCTGTCTCGGGTAAAGGCTTCTGCAAGTCCCTCTTTTCCTGGCTGTATAG
GCTACCTCTTGGAAGAAAGTCCTTGTCCTTTGAGACTCAGAAGGCCCCACGCTCCAGTATGCCATCATGATGCCTGCTAAGGCAGCCACC
TTGGTGTACATGCTCACAGAGGCTCTGTTCATGGAGCAGCTGCTGTTTGAAAAATTTTGAAATGCAAGATCCACAACTAGATGGAAGGCA
CTCTAGTCTTTGCAGAAAAAAATGTACCTGAATGTACATTGCACAATGCCTGGCACAAAGAAGGAAGAATATAAATGATAGTTCGACTCG

>60951_60951_5_NUMB-TSHR_NUMB_chr14_73822334_ENST00000355058_TSHR_chr14_81528492_ENST00000554435_length(amino acids)=247AA_BP=29
MFMFQRPVVHISGRQMKKAFAPENVASRLRKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYI
DPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYL

--------------------------------------------------------------
>60951_60951_6_NUMB-TSHR_NUMB_chr14_73822334_ENST00000356296_TSHR_chr14_81528492_ENST00000298171_length(transcript)=4479nt_BP=405nt
GCTTGAGTTGGTCGGGGGCAGCGGCAGCTGAGCTGGGATGGGAGACCCAACTGGCCTGGCCGCTCCGGCTCTGAGGATCCCTAAGGGACC
AGGAAAGAAGTCCTCGAGGAGTGGCTCGCGTTTGAGACCGGGATTTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTGCCAGTGCAGCCA
CTGTTACAATTCAAGATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCACTTAGGACAAGCTGTA
AAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACA
GATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGGAAGCTTATTGAGACTCACCTGAGAACTATTCCAAGTCATGCATT
TTCTAATCTGCCCAATATTTCCAGAATCTACGTATCTATAGATGTGACTCTGCAGCAGCTGGAATCACACTCCTTCTACAATTTGAGTAA
AGTGACTCACATAGAAATTCGGAATACCAGGAACTTAACTTACATAGACCCTGATGCCCTCAAAGAGCTCCCCCTCCTAAAGTTCCTTGG
CATTTTCAACACTGGACTTAAAATGTTCCCTGACCTGACCAAAGTTTATTCCACTGATATATTCTTTATACTTGAAATTACAGACAACCC
TTACATGACGTCAATCCCTGTGAATGCTTTTCAGGGACTATGCAATGAAACCTTGACACTGAAGCTGTACAACAATGGCTTTACTTCAGT
CCAAGGATATGCTTTCAATGGGACAAAGCTGGATGCTGTTTACCTAAACAAGAATAAATACCTGACAGTTATTGACAAAGATGCATTTGG
AGGAGTATACAGTGGACCAAGCTTGCTGGACGTGTCTCAAACCAGTGTCACTGCCCTTCCATCCAAAGGCCTGGAGCACCTGAAGGAACT
GATAGCAAGAAACACCTGGACTCTTAAGAAACTTCCACTTTCCTTGAGTTTCCTTCACCTCACACGGGCTGACCTTTCTTACCCAAGCCA
CTGCTGTGCTTTTAAGAATCAGAAGAAAATCAGAGGAATCCTTGAGTCCTTGATGTGTAATGAGAGCAGTATGCAGAGCTTGCGCCAGAG
AAAATCTGTGAATGCCTTGAATAGCCCCCTCCACCAGGAATATGAAGAGAATCTGGGTGACAGCATTGTTGGGTACAAGGAAAAGTCCAA
GTTCCAGGATACTCATAACAACGCTCATTATTACGTCTTCTTTGAAGAACAAGAGGATGAGATCATTGGTTTTGGCCAGGAGCTCAAAAA
CCCCCAGGAAGAGACTCTACAAGCTTTTGACAGCCATTATGACTACACCATATGTGGGGACAGTGAAGACATGGTGTGTACCCCCAAGTC
CGATGAGTTCAACCCGTGTGAAGACATAATGGGCTACAAGTTCCTGAGAATTGTGGTGTGGTTCGTTAGTCTGCTGGCTCTCCTGGGCAA
TGTCTTTGTCCTGCTTATTCTCCTCACCAGCCACTACAAACTGAACGTCCCCCGCTTTCTCATGTGCAACCTGGCCTTTGCGGATTTCTG
CATGGGGATGTACCTGCTCCTCATCGCCTCTGTAGACCTCTACACTCACTCTGAGTACTACAACCATGCCATCGACTGGCAGACAGGCCC
TGGGTGCAACACGGCTGGTTTCTTCACTGTCTTTGCAAGCGAGTTATCGGTGTATACGCTGACGGTCATCACCCTGGAGCGCTGGTATGC
CATCACCTTCGCCATGCGCCTGGACCGGAAGATCCGCCTCAGGCACGCATGTGCCATCATGGTTGGGGGCTGGGTTTGCTGCTTCCTTCT
CGCCCTGCTTCCTTTGGTGGGAATAAGTAGCTATGCCAAAGTCAGTATCTGCCTGCCCATGGACACCGAGACCCCTCTTGCTCTGGCATA
TATTGTTTTTGTTCTGACGCTCAACATAGTTGCCTTCGTCATCGTCTGCTGCTGTTATGTGAAGATCTACATCACAGTCCGAAATCCGCA
GTACAACCCAGGGGACAAAGATACCAAAATTGCCAAGAGGATGGCTGTGTTGATCTTCACCGACTTCATATGCATGGCCCCAATCTCATT
CTATGCTCTGTCAGCAATTCTGAACAAGCCTCTCATCACTGTTAGCAACTCCAAAATCTTGCTGGTACTCTTCTATCCACTTAACTCCTG
TGCCAATCCATTCCTCTATGCTATTTTCACCAAGGCCTTCCAGAGGGATGTGTTCATCCTACTCAGCAAGTTTGGCATCTGTAAACGCCA
GGCTCAGGCATACCGGGGGCAGAGGGTTCCTCCAAAGAACAGCACTGATATTCAGGTTCAAAAGGTTACCCACGAGATGAGGCAGGGTCT
CCACAACATGGAAGATGTCTATGAACTGATTGAAAACTCCCATCTAACCCCAAAGAAGCAAGGCCAAATCTCAGAAGAGTATATGCAAAC
GGTTTTGTAAGTTAACACTACACTACTCACAATGGTAGGGGAACTTACAAAATAATAGTTTCTTGAATATGCATTCCAATCCCATGACAC
CCCCAACACATAGCTGCCCTCACTCTTGTGCAGGCGATGTTTCAATGTTTCATGGGGCAAGAGTTTATCTCTGGAGAGTGATTAGTATTA
ACCTAATCATTGCCCCCAAGAAGGAAGTTAGGCTACCAGCATATTTGAATGCCAGGTGAAATCAAAATAATCTACACTATCTAGAAGACT
TTCTTGATGCCAAGTCCAGAGATGTCATTGTGTAGGATGTTCAGTAAATATTAACTGAGCTATGTCAATATAGAGCTTCTCAGTTTTGTA
TAACATTTCATACTAAAGATTCAGCAAATGGAAAATGCTATTAATTTGGTTGGTGACCACAAGATAAAATCAGTCCCACGTTGGCTCAGT
TCAACTAGATGTTCCCTGATACAAAGAGAACTTGATTTCCTTAAAACTGAAAAGCCAAACACAGCTAGCTGTCATACAAGAAACAGCTAT
TATGAGACATGAAGGAGGGTAAGAATTAGCTTTAAGTTTTGTTTTGCTTTGTTTTGTTTTTTAACTCAACCTATTAATCATCTCTTCACA
AGAATCCACCTGATGTGACCAAGCTATTATGTGTTGCCTGGAAAAACTGGCAAGATTTCAGCTTATGTGGCCTAGCAAACTAAGAATTGC
TCTTCTTGGCCAGCCTCATAGCATAAAAGATGTGAACTCTAGGAAGTCTTTCTGAGTAGCAATAAGTGGGAATTATGGGCAGAGCACACT
CAATCCCCTGTTGATTAATAAAACAGGCTGGACACTAATTAACTATGGGACTTAAATCTGTAGAAATGAAGGAGTCCAATAGCTTCTTCC
AATTTTAAAACTCTAGTACATCCCTTTCCCTCAAATATATATTTCTAAGATAAAGAGAAAGAAGAGCACTAAGTAAGTAGAATCTGTTTT
TCCTATTTTGTAGGGCTGCTGACTCCTAGTCCTTGAAGCCTAGACACATGACCCAGGAAATTTTTCCTTTGTTTCACTTTTGATTATGAT
GTCTGAGCCAAAAATTCAATTAAGTAAACATACTCGCCTGGATCTGAATCATTCATTTAATTACTAGATCTACCCAGCTGTTATATCAGG
CCAAAAACAGATTCGTGTTTATATAAAAGAGTAAACGATGGTTGCAAATTTTGGCTATTTAGAGTTGCTACTTCACTATGAAGAGTCACT
TCAAAACACTTCGCTTGTCTTTAGGGATGATTTTTGCCATTTCCAGTCCACGGTATGATACTAAAGCTGTCAAGAGAGGTTTCTTCTTTT
CTGAAACTGCCAGCTCTTTCCAGCCCTGTTGATCACTGGACATAAAGCTTCTTTTCCCCAATAATTCTTCTTTACTTAAAATAGTCAGGA
TCTTTATCTACAGATGTACTCTCCAGGTTACCTGTGATGATAGCCCCCTAATGTCCTGCTAGAAAAGTCTCCAAGCAGAGATGACATTAC
TTCTGAATGCTCATAAACCACACCATGAAATAAAAGCTCTTTGTTGTTTTAAGATTGTGAAGTGTCGTTAATGGGTCCCCACAGATGGTC
CCTGCTGGACTCACCTGGAATCTCTCCACAGCCATACCCACTCATCACTATCATTGAGACCTGCACATCTTAATAGAAATATTATAAACA
TCGAAAATCATGACTTACCTAGAAGTTCGCTTGTAACTAATGAAATTAAACAAATGTGTTGCCTTTTGTCATGTGTTTCTCTCCTGTGAC
ATTTCAAAATATCACATCTTGATAAATAATGTGTTTCATCTTGAATAGCTGAACTAATTGCTTTGGAAACAGAGTCCTAGAAAAGTGACT

>60951_60951_6_NUMB-TSHR_NUMB_chr14_73822334_ENST00000356296_TSHR_chr14_81528492_ENST00000298171_length(amino acids)=737AA_BP=29
MFMFQRPVVHISGRQMKKAFAPENVASRLRKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYI
DPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYL
NKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILE
SLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDY
TICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYT
HSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVS
ICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVS
NSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHEMRQGLHNMEDVYELIENSHL

--------------------------------------------------------------
>60951_60951_7_NUMB-TSHR_NUMB_chr14_73822334_ENST00000356296_TSHR_chr14_81528492_ENST00000342443_length(transcript)=1266nt_BP=405nt
GCTTGAGTTGGTCGGGGGCAGCGGCAGCTGAGCTGGGATGGGAGACCCAACTGGCCTGGCCGCTCCGGCTCTGAGGATCCCTAAGGGACC
AGGAAAGAAGTCCTCGAGGAGTGGCTCGCGTTTGAGACCGGGATTTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTGCCAGTGCAGCCA
CTGTTACAATTCAAGATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCACTTAGGACAAGCTGTA
AAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACA
GATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGGAAGCTTATTGAGACTCACCTGAGAACTATTCCAAGTCATGCATT
TTCTAATCTGCCCAATATTTCCAGAATCTACGTATCTATAGATGTGACTCTGCAGCAGCTGGAATCACACTCCTTCTACAATTTGAGTAA
AGTGACTCACATAGAAATTCGGAATACCAGGAACTTAACTTACATAGACCCTGATGCCCTCAAAGAGCTCCCCCTCCTAAAGTTCCTTGG
CATTTTCAACACTGGACTTAAAATGTTCCCTGACCTGACCAAAGTTTATTCCACTGATATATTCTTTATACTTGAAATTACAGACAACCC
TTACATGACGTCAATCCCTGTGAATGCTTTTCAGGGACTATGCAATGAAACCTTGACACTGAAGCTGTACAACAATGGCTTTACTTCAGT
CCAAGGATATGCTTTCAATGGGACAAAGCTGGATGCTGTTTACCTAAACAAGAATAAATACCTGACAGTTATTGACAAAGATGCATTTGG
AGGAGTATACAGTGGACCAAGCTTGCTGCTACCTCTTGGAAGAAAGTCCTTGTCCTTTGAGACTCAGAAGGCCCCACGCTCCAGTATGCC
ATCATGATGCCTGCTAAGGCAGCCACCTTGGTGTACATGCTCACAGAGGCTCTGTTCATGGAGCAGCTGCTGTTTGAAAAATTTTGAAAT
GCAAGATCCACAACTAGATGGAAGGCACTCTAGTCTTTGCAGAAAAAAATGTACCTGAATGTACATTGCACAATGCCTGGCACAAAGAAG
GAAGAATATAAATGATAGTTCGACTCGTCTGTGGAAGAACTTACAATCATGGGGAAAGATGGAATAAAAACATTTTTTAAACAGCATGAA

>60951_60951_7_NUMB-TSHR_NUMB_chr14_73822334_ENST00000356296_TSHR_chr14_81528492_ENST00000342443_length(amino acids)=226AA_BP=29
MFMFQRPVVHISGRQMKKAFAPENVASRLRKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYI
DPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYL

--------------------------------------------------------------
>60951_60951_8_NUMB-TSHR_NUMB_chr14_73822334_ENST00000356296_TSHR_chr14_81528492_ENST00000541158_length(transcript)=4479nt_BP=405nt
GCTTGAGTTGGTCGGGGGCAGCGGCAGCTGAGCTGGGATGGGAGACCCAACTGGCCTGGCCGCTCCGGCTCTGAGGATCCCTAAGGGACC
AGGAAAGAAGTCCTCGAGGAGTGGCTCGCGTTTGAGACCGGGATTTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTGCCAGTGCAGCCA
CTGTTACAATTCAAGATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCACTTAGGACAAGCTGTA
AAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACA
GATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGGAAGCTTATTGAGACTCACCTGAGAACTATTCCAAGTCATGCATT
TTCTAATCTGCCCAATATTTCCAGAATCTACGTATCTATAGATGTGACTCTGCAGCAGCTGGAATCACACTCCTTCTACAATTTGAGTAA
AGTGACTCACATAGAAATTCGGAATACCAGGAACTTAACTTACATAGACCCTGATGCCCTCAAAGAGCTCCCCCTCCTAAAGTTCCTTGG
CATTTTCAACACTGGACTTAAAATGTTCCCTGACCTGACCAAAGTTTATTCCACTGATATATTCTTTATACTTGAAATTACAGACAACCC
TTACATGACGTCAATCCCTGTGAATGCTTTTCAGGGACTATGCAATGAAACCTTGACACTGAAGCTGTACAACAATGGCTTTACTTCAGT
CCAAGGATATGCTTTCAATGGGACAAAGCTGGATGCTGTTTACCTAAACAAGAATAAATACCTGACAGTTATTGACAAAGATGCATTTGG
AGGAGTATACAGTGGACCAAGCTTGCTGGACGTGTCTCAAACCAGTGTCACTGCCCTTCCATCCAAAGGCCTGGAGCACCTGAAGGAACT
GATAGCAAGAAACACCTGGACTCTTAAGAAACTTCCACTTTCCTTGAGTTTCCTTCACCTCACACGGGCTGACCTTTCTTACCCAAGCCA
CTGCTGTGCTTTTAAGAATCAGAAGAAAATCAGAGGAATCCTTGAGTCCTTGATGTGTAATGAGAGCAGTATGCAGAGCTTGCGCCAGAG
AAAATCTGTGAATGCCTTGAATAGCCCCCTCCACCAGGAATATGAAGAGAATCTGGGTGACAGCATTGTTGGGTACAAGGAAAAGTCCAA
GTTCCAGGATACTCATAACAACGCTCATTATTACGTCTTCTTTGAAGAACAAGAGGATGAGATCATTGGTTTTGGCCAGGAGCTCAAAAA
CCCCCAGGAAGAGACTCTACAAGCTTTTGACAGCCATTATGACTACACCATATGTGGGGACAGTGAAGACATGGTGTGTACCCCCAAGTC
CGATGAGTTCAACCCGTGTGAAGACATAATGGGCTACAAGTTCCTGAGAATTGTGGTGTGGTTCGTTAGTCTGCTGGCTCTCCTGGGCAA
TGTCTTTGTCCTGCTTATTCTCCTCACCAGCCACTACAAACTGAACGTCCCCCGCTTTCTCATGTGCAACCTGGCCTTTGCGGATTTCTG
CATGGGGATGTACCTGCTCCTCATCGCCTCTGTAGACCTCTACACTCACTCTGAGTACTACAACCATGCCATCGACTGGCAGACAGGCCC
TGGGTGCAACACGGCTGGTTTCTTCACTGTCTTTGCAAGCGAGTTATCGGTGTATACGCTGACGGTCATCACCCTGGAGCGCTGGTATGC
CATCACCTTCGCCATGCGCCTGGACCGGAAGATCCGCCTCAGGCACGCATGTGCCATCATGGTTGGGGGCTGGGTTTGCTGCTTCCTTCT
CGCCCTGCTTCCTTTGGTGGGAATAAGTAGCTATGCCAAAGTCAGTATCTGCCTGCCCATGGACACCGAGACCCCTCTTGCTCTGGCATA
TATTGTTTTTGTTCTGACGCTCAACATAGTTGCCTTCGTCATCGTCTGCTGCTGTTATGTGAAGATCTACATCACAGTCCGAAATCCGCA
GTACAACCCAGGGGACAAAGATACCAAAATTGCCAAGAGGATGGCTGTGTTGATCTTCACCGACTTCATATGCATGGCCCCAATCTCATT
CTATGCTCTGTCAGCAATTCTGAACAAGCCTCTCATCACTGTTAGCAACTCCAAAATCTTGCTGGTACTCTTCTATCCACTTAACTCCTG
TGCCAATCCATTCCTCTATGCTATTTTCACCAAGGCCTTCCAGAGGGATGTGTTCATCCTACTCAGCAAGTTTGGCATCTGTAAACGCCA
GGCTCAGGCATACCGGGGGCAGAGGGTTCCTCCAAAGAACAGCACTGATATTCAGGTTCAAAAGGTTACCCACGAGATGAGGCAGGGTCT
CCACAACATGGAAGATGTCTATGAACTGATTGAAAACTCCCATCTAACCCCAAAGAAGCAAGGCCAAATCTCAGAAGAGTATATGCAAAC
GGTTTTGTAAGTTAACACTACACTACTCACAATGGTAGGGGAACTTACAAAATAATAGTTTCTTGAATATGCATTCCAATCCCATGACAC
CCCCAACACATAGCTGCCCTCACTCTTGTGCAGGCGATGTTTCAATGTTTCATGGGGCAAGAGTTTATCTCTGGAGAGTGATTAGTATTA
ACCTAATCATTGCCCCCAAGAAGGAAGTTAGGCTACCAGCATATTTGAATGCCAGGTGAAATCAAAATAATCTACACTATCTAGAAGACT
TTCTTGATGCCAAGTCCAGAGATGTCATTGTGTAGGATGTTCAGTAAATATTAACTGAGCTATGTCAATATAGAGCTTCTCAGTTTTGTA
TAACATTTCATACTAAAGATTCAGCAAATGGAAAATGCTATTAATTTGGTTGGTGACCACAAGATAAAATCAGTCCCACGTTGGCTCAGT
TCAACTAGATGTTCCCTGATACAAAGAGAACTTGATTTCCTTAAAACTGAAAAGCCAAACACAGCTAGCTGTCATACAAGAAACAGCTAT
TATGAGACATGAAGGAGGGTAAGAATTAGCTTTAAGTTTTGTTTTGCTTTGTTTTGTTTTTTAACTCAACCTATTAATCATCTCTTCACA
AGAATCCACCTGATGTGACCAAGCTATTATGTGTTGCCTGGAAAAACTGGCAAGATTTCAGCTTATGTGGCCTAGCAAACTAAGAATTGC
TCTTCTTGGCCAGCCTCATAGCATAAAAGATGTGAACTCTAGGAAGTCTTTCTGAGTAGCAATAAGTGGGAATTATGGGCAGAGCACACT
CAATCCCCTGTTGATTAATAAAACAGGCTGGACACTAATTAACTATGGGACTTAAATCTGTAGAAATGAAGGAGTCCAATAGCTTCTTCC
AATTTTAAAACTCTAGTACATCCCTTTCCCTCAAATATATATTTCTAAGATAAAGAGAAAGAAGAGCACTAAGTAAGTAGAATCTGTTTT
TCCTATTTTGTAGGGCTGCTGACTCCTAGTCCTTGAAGCCTAGACACATGACCCAGGAAATTTTTCCTTTGTTTCACTTTTGATTATGAT
GTCTGAGCCAAAAATTCAATTAAGTAAACATACTCGCCTGGATCTGAATCATTCATTTAATTACTAGATCTACCCAGCTGTTATATCAGG
CCAAAAACAGATTCGTGTTTATATAAAAGAGTAAACGATGGTTGCAAATTTTGGCTATTTAGAGTTGCTACTTCACTATGAAGAGTCACT
TCAAAACACTTCGCTTGTCTTTAGGGATGATTTTTGCCATTTCCAGTCCACGGTATGATACTAAAGCTGTCAAGAGAGGTTTCTTCTTTT
CTGAAACTGCCAGCTCTTTCCAGCCCTGTTGATCACTGGACATAAAGCTTCTTTTCCCCAATAATTCTTCTTTACTTAAAATAGTCAGGA
TCTTTATCTACAGATGTACTCTCCAGGTTACCTGTGATGATAGCCCCCTAATGTCCTGCTAGAAAAGTCTCCAAGCAGAGATGACATTAC
TTCTGAATGCTCATAAACCACACCATGAAATAAAAGCTCTTTGTTGTTTTAAGATTGTGAAGTGTCGTTAATGGGTCCCCACAGATGGTC
CCTGCTGGACTCACCTGGAATCTCTCCACAGCCATACCCACTCATCACTATCATTGAGACCTGCACATCTTAATAGAAATATTATAAACA
TCGAAAATCATGACTTACCTAGAAGTTCGCTTGTAACTAATGAAATTAAACAAATGTGTTGCCTTTTGTCATGTGTTTCTCTCCTGTGAC
ATTTCAAAATATCACATCTTGATAAATAATGTGTTTCATCTTGAATAGCTGAACTAATTGCTTTGGAAACAGAGTCCTAGAAAAGTGACT

>60951_60951_8_NUMB-TSHR_NUMB_chr14_73822334_ENST00000356296_TSHR_chr14_81528492_ENST00000541158_length(amino acids)=737AA_BP=29
MFMFQRPVVHISGRQMKKAFAPENVASRLRKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYI
DPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYL
NKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILE
SLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDY
TICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYT
HSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVS
ICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVS
NSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHEMRQGLHNMEDVYELIENSHL

--------------------------------------------------------------
>60951_60951_9_NUMB-TSHR_NUMB_chr14_73822334_ENST00000356296_TSHR_chr14_81528492_ENST00000554263_length(transcript)=1393nt_BP=405nt
GCTTGAGTTGGTCGGGGGCAGCGGCAGCTGAGCTGGGATGGGAGACCCAACTGGCCTGGCCGCTCCGGCTCTGAGGATCCCTAAGGGACC
AGGAAAGAAGTCCTCGAGGAGTGGCTCGCGTTTGAGACCGGGATTTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTGCCAGTGCAGCCA
CTGTTACAATTCAAGATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCACTTAGGACAAGCTGTA
AAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACA
GATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGGAAGCTTATTGAGACTCACCTGAGAACTATTCCAAGTCATGCATT
TTCTAATCTGCCCAATATTTCCAGAATCTACGTATCTATAGATGTGACTCTGCAGCAGCTGGAATCACACTCCTTCTACAATTTGAGTAA
AGTGACTCACATAGAAATTCGGAATACCAGGAACTTAACTTACATAGACCCTGATGCCCTCAAAGAGCTCCCCCTCCTAAAGTTCCTTGG
CATTTTCAACACTGGACTTAAAATGTTCCCTGACCTGACCAAAGTTTATTCCACTGATATATTCTTTATACTTGAAATTACAGACAACCC
TTACATGACGTCAATCCCTGTGAATGCTTTTCAGGGACTATGCAATGAAACCTTGACACTGAAGCTGTACAACAATGGCTTTACTTCAGT
CCAAGGATATGCTTTCAATGGGACAAAGCTGGATGCTGTTTACCTAAACAAGAATAAATACCTGACAGTTATTGACAAAGATGCATTTGG
AGGAGTATACAGTGGACCAAGCTTGCTGTGAGTAAGACATACAAAAGAATATTTTAGTCTTTTTTTTTCTTTTTTTTTTTTTGGAATAAA
TGGAGACATTAAGGGGAGAATCTTATGTTCAAGGGTAGAAAATGTTGCTGTCTCGGGTAAAGGCTTCTGCAAGTCCCTCTTTTCCTGGCT
GTATAGGCTACCTCTTGGAAGAAAGTCCTTGTCCTTTGAGACTCAGAAGGCCCCACGCTCCAGTATGCCATCATGATGCCTGCTAAGGCA
GCCACCTTGGTGTACATGCTCACAGAGGCTCTGTTCATGGAGCAGCTGCTGTTTGAAAAATTTTGAAATGCAAGATCCACAACTAGATGG
AAGGCACTCTAGTCTTTGCAGAAAAAAATGTACCTGAATGTACATTGCACAATGCCTGGCACAAAGAAGGAAGAATATAAATGATAGTTC

>60951_60951_9_NUMB-TSHR_NUMB_chr14_73822334_ENST00000356296_TSHR_chr14_81528492_ENST00000554263_length(amino acids)=204AA_BP=29
MFMFQRPVVHISGRQMKKAFAPENVASRLRKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYI
DPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYL

--------------------------------------------------------------
>60951_60951_10_NUMB-TSHR_NUMB_chr14_73822334_ENST00000356296_TSHR_chr14_81528492_ENST00000554435_length(transcript)=1298nt_BP=405nt
GCTTGAGTTGGTCGGGGGCAGCGGCAGCTGAGCTGGGATGGGAGACCCAACTGGCCTGGCCGCTCCGGCTCTGAGGATCCCTAAGGGACC
AGGAAAGAAGTCCTCGAGGAGTGGCTCGCGTTTGAGACCGGGATTTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTGCCAGTGCAGCCA
CTGTTACAATTCAAGATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCACTTAGGACAAGCTGTA
AAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACA
GATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGGAAGCTTATTGAGACTCACCTGAGAACTATTCCAAGTCATGCATT
TTCTAATCTGCCCAATATTTCCAGAATCTACGTATCTATAGATGTGACTCTGCAGCAGCTGGAATCACACTCCTTCTACAATTTGAGTAA
AGTGACTCACATAGAAATTCGGAATACCAGGAACTTAACTTACATAGACCCTGATGCCCTCAAAGAGCTCCCCCTCCTAAAGTTCCTTGG
CATTTTCAACACTGGACTTAAAATGTTCCCTGACCTGACCAAAGTTTATTCCACTGATATATTCTTTATACTTGAAATTACAGACAACCC
TTACATGACGTCAATCCCTGTGAATGCTTTTCAGGGACTATGCAATGAAACCTTGACACTGAAGCTGTACAACAATGGCTTTACTTCAGT
CCAAGGATATGCTTTCAATGGGACAAAGCTGGATGCTGTTTACCTAAACAAGAATAAATACCTGACAGTTATTGACAAAGATGCATTTGG
AGGAGTATACAGTGGACCAAGCTTGCTGGTAGAAAATGTTGCTGTCTCGGGTAAAGGCTTCTGCAAGTCCCTCTTTTCCTGGCTGTATAG
GCTACCTCTTGGAAGAAAGTCCTTGTCCTTTGAGACTCAGAAGGCCCCACGCTCCAGTATGCCATCATGATGCCTGCTAAGGCAGCCACC
TTGGTGTACATGCTCACAGAGGCTCTGTTCATGGAGCAGCTGCTGTTTGAAAAATTTTGAAATGCAAGATCCACAACTAGATGGAAGGCA
CTCTAGTCTTTGCAGAAAAAAATGTACCTGAATGTACATTGCACAATGCCTGGCACAAAGAAGGAAGAATATAAATGATAGTTCGACTCG

>60951_60951_10_NUMB-TSHR_NUMB_chr14_73822334_ENST00000356296_TSHR_chr14_81528492_ENST00000554435_length(amino acids)=247AA_BP=29
MFMFQRPVVHISGRQMKKAFAPENVASRLRKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYI
DPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYL

--------------------------------------------------------------
>60951_60951_11_NUMB-TSHR_NUMB_chr14_73822334_ENST00000359560_TSHR_chr14_81528492_ENST00000298171_length(transcript)=4479nt_BP=405nt
GCTTGAGTTGGTCGGGGGCAGCGGCAGCTGAGCTGGGATGGGAGACCCAACTGGCCTGGCCGCTCCGGCTCTGAGGATCCCTAAGGGACC
AGGAAAGAAGTCCTCGAGGAGTGGCTCGCGTTTGAGACCGGGATTTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTGCCAGTGCAGCCA
CTGTTACAATTCAAGATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCACTTAGGACAAGCTGTA
AAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACA
GATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGGAAGCTTATTGAGACTCACCTGAGAACTATTCCAAGTCATGCATT
TTCTAATCTGCCCAATATTTCCAGAATCTACGTATCTATAGATGTGACTCTGCAGCAGCTGGAATCACACTCCTTCTACAATTTGAGTAA
AGTGACTCACATAGAAATTCGGAATACCAGGAACTTAACTTACATAGACCCTGATGCCCTCAAAGAGCTCCCCCTCCTAAAGTTCCTTGG
CATTTTCAACACTGGACTTAAAATGTTCCCTGACCTGACCAAAGTTTATTCCACTGATATATTCTTTATACTTGAAATTACAGACAACCC
TTACATGACGTCAATCCCTGTGAATGCTTTTCAGGGACTATGCAATGAAACCTTGACACTGAAGCTGTACAACAATGGCTTTACTTCAGT
CCAAGGATATGCTTTCAATGGGACAAAGCTGGATGCTGTTTACCTAAACAAGAATAAATACCTGACAGTTATTGACAAAGATGCATTTGG
AGGAGTATACAGTGGACCAAGCTTGCTGGACGTGTCTCAAACCAGTGTCACTGCCCTTCCATCCAAAGGCCTGGAGCACCTGAAGGAACT
GATAGCAAGAAACACCTGGACTCTTAAGAAACTTCCACTTTCCTTGAGTTTCCTTCACCTCACACGGGCTGACCTTTCTTACCCAAGCCA
CTGCTGTGCTTTTAAGAATCAGAAGAAAATCAGAGGAATCCTTGAGTCCTTGATGTGTAATGAGAGCAGTATGCAGAGCTTGCGCCAGAG
AAAATCTGTGAATGCCTTGAATAGCCCCCTCCACCAGGAATATGAAGAGAATCTGGGTGACAGCATTGTTGGGTACAAGGAAAAGTCCAA
GTTCCAGGATACTCATAACAACGCTCATTATTACGTCTTCTTTGAAGAACAAGAGGATGAGATCATTGGTTTTGGCCAGGAGCTCAAAAA
CCCCCAGGAAGAGACTCTACAAGCTTTTGACAGCCATTATGACTACACCATATGTGGGGACAGTGAAGACATGGTGTGTACCCCCAAGTC
CGATGAGTTCAACCCGTGTGAAGACATAATGGGCTACAAGTTCCTGAGAATTGTGGTGTGGTTCGTTAGTCTGCTGGCTCTCCTGGGCAA
TGTCTTTGTCCTGCTTATTCTCCTCACCAGCCACTACAAACTGAACGTCCCCCGCTTTCTCATGTGCAACCTGGCCTTTGCGGATTTCTG
CATGGGGATGTACCTGCTCCTCATCGCCTCTGTAGACCTCTACACTCACTCTGAGTACTACAACCATGCCATCGACTGGCAGACAGGCCC
TGGGTGCAACACGGCTGGTTTCTTCACTGTCTTTGCAAGCGAGTTATCGGTGTATACGCTGACGGTCATCACCCTGGAGCGCTGGTATGC
CATCACCTTCGCCATGCGCCTGGACCGGAAGATCCGCCTCAGGCACGCATGTGCCATCATGGTTGGGGGCTGGGTTTGCTGCTTCCTTCT
CGCCCTGCTTCCTTTGGTGGGAATAAGTAGCTATGCCAAAGTCAGTATCTGCCTGCCCATGGACACCGAGACCCCTCTTGCTCTGGCATA
TATTGTTTTTGTTCTGACGCTCAACATAGTTGCCTTCGTCATCGTCTGCTGCTGTTATGTGAAGATCTACATCACAGTCCGAAATCCGCA
GTACAACCCAGGGGACAAAGATACCAAAATTGCCAAGAGGATGGCTGTGTTGATCTTCACCGACTTCATATGCATGGCCCCAATCTCATT
CTATGCTCTGTCAGCAATTCTGAACAAGCCTCTCATCACTGTTAGCAACTCCAAAATCTTGCTGGTACTCTTCTATCCACTTAACTCCTG
TGCCAATCCATTCCTCTATGCTATTTTCACCAAGGCCTTCCAGAGGGATGTGTTCATCCTACTCAGCAAGTTTGGCATCTGTAAACGCCA
GGCTCAGGCATACCGGGGGCAGAGGGTTCCTCCAAAGAACAGCACTGATATTCAGGTTCAAAAGGTTACCCACGAGATGAGGCAGGGTCT
CCACAACATGGAAGATGTCTATGAACTGATTGAAAACTCCCATCTAACCCCAAAGAAGCAAGGCCAAATCTCAGAAGAGTATATGCAAAC
GGTTTTGTAAGTTAACACTACACTACTCACAATGGTAGGGGAACTTACAAAATAATAGTTTCTTGAATATGCATTCCAATCCCATGACAC
CCCCAACACATAGCTGCCCTCACTCTTGTGCAGGCGATGTTTCAATGTTTCATGGGGCAAGAGTTTATCTCTGGAGAGTGATTAGTATTA
ACCTAATCATTGCCCCCAAGAAGGAAGTTAGGCTACCAGCATATTTGAATGCCAGGTGAAATCAAAATAATCTACACTATCTAGAAGACT
TTCTTGATGCCAAGTCCAGAGATGTCATTGTGTAGGATGTTCAGTAAATATTAACTGAGCTATGTCAATATAGAGCTTCTCAGTTTTGTA
TAACATTTCATACTAAAGATTCAGCAAATGGAAAATGCTATTAATTTGGTTGGTGACCACAAGATAAAATCAGTCCCACGTTGGCTCAGT
TCAACTAGATGTTCCCTGATACAAAGAGAACTTGATTTCCTTAAAACTGAAAAGCCAAACACAGCTAGCTGTCATACAAGAAACAGCTAT
TATGAGACATGAAGGAGGGTAAGAATTAGCTTTAAGTTTTGTTTTGCTTTGTTTTGTTTTTTAACTCAACCTATTAATCATCTCTTCACA
AGAATCCACCTGATGTGACCAAGCTATTATGTGTTGCCTGGAAAAACTGGCAAGATTTCAGCTTATGTGGCCTAGCAAACTAAGAATTGC
TCTTCTTGGCCAGCCTCATAGCATAAAAGATGTGAACTCTAGGAAGTCTTTCTGAGTAGCAATAAGTGGGAATTATGGGCAGAGCACACT
CAATCCCCTGTTGATTAATAAAACAGGCTGGACACTAATTAACTATGGGACTTAAATCTGTAGAAATGAAGGAGTCCAATAGCTTCTTCC
AATTTTAAAACTCTAGTACATCCCTTTCCCTCAAATATATATTTCTAAGATAAAGAGAAAGAAGAGCACTAAGTAAGTAGAATCTGTTTT
TCCTATTTTGTAGGGCTGCTGACTCCTAGTCCTTGAAGCCTAGACACATGACCCAGGAAATTTTTCCTTTGTTTCACTTTTGATTATGAT
GTCTGAGCCAAAAATTCAATTAAGTAAACATACTCGCCTGGATCTGAATCATTCATTTAATTACTAGATCTACCCAGCTGTTATATCAGG
CCAAAAACAGATTCGTGTTTATATAAAAGAGTAAACGATGGTTGCAAATTTTGGCTATTTAGAGTTGCTACTTCACTATGAAGAGTCACT
TCAAAACACTTCGCTTGTCTTTAGGGATGATTTTTGCCATTTCCAGTCCACGGTATGATACTAAAGCTGTCAAGAGAGGTTTCTTCTTTT
CTGAAACTGCCAGCTCTTTCCAGCCCTGTTGATCACTGGACATAAAGCTTCTTTTCCCCAATAATTCTTCTTTACTTAAAATAGTCAGGA
TCTTTATCTACAGATGTACTCTCCAGGTTACCTGTGATGATAGCCCCCTAATGTCCTGCTAGAAAAGTCTCCAAGCAGAGATGACATTAC
TTCTGAATGCTCATAAACCACACCATGAAATAAAAGCTCTTTGTTGTTTTAAGATTGTGAAGTGTCGTTAATGGGTCCCCACAGATGGTC
CCTGCTGGACTCACCTGGAATCTCTCCACAGCCATACCCACTCATCACTATCATTGAGACCTGCACATCTTAATAGAAATATTATAAACA
TCGAAAATCATGACTTACCTAGAAGTTCGCTTGTAACTAATGAAATTAAACAAATGTGTTGCCTTTTGTCATGTGTTTCTCTCCTGTGAC
ATTTCAAAATATCACATCTTGATAAATAATGTGTTTCATCTTGAATAGCTGAACTAATTGCTTTGGAAACAGAGTCCTAGAAAAGTGACT

>60951_60951_11_NUMB-TSHR_NUMB_chr14_73822334_ENST00000359560_TSHR_chr14_81528492_ENST00000298171_length(amino acids)=737AA_BP=29
MFMFQRPVVHISGRQMKKAFAPENVASRLRKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYI
DPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYL
NKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILE
SLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDY
TICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYT
HSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVS
ICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVS
NSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHEMRQGLHNMEDVYELIENSHL

--------------------------------------------------------------
>60951_60951_12_NUMB-TSHR_NUMB_chr14_73822334_ENST00000359560_TSHR_chr14_81528492_ENST00000342443_length(transcript)=1266nt_BP=405nt
GCTTGAGTTGGTCGGGGGCAGCGGCAGCTGAGCTGGGATGGGAGACCCAACTGGCCTGGCCGCTCCGGCTCTGAGGATCCCTAAGGGACC
AGGAAAGAAGTCCTCGAGGAGTGGCTCGCGTTTGAGACCGGGATTTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTGCCAGTGCAGCCA
CTGTTACAATTCAAGATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCACTTAGGACAAGCTGTA
AAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACA
GATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGGAAGCTTATTGAGACTCACCTGAGAACTATTCCAAGTCATGCATT
TTCTAATCTGCCCAATATTTCCAGAATCTACGTATCTATAGATGTGACTCTGCAGCAGCTGGAATCACACTCCTTCTACAATTTGAGTAA
AGTGACTCACATAGAAATTCGGAATACCAGGAACTTAACTTACATAGACCCTGATGCCCTCAAAGAGCTCCCCCTCCTAAAGTTCCTTGG
CATTTTCAACACTGGACTTAAAATGTTCCCTGACCTGACCAAAGTTTATTCCACTGATATATTCTTTATACTTGAAATTACAGACAACCC
TTACATGACGTCAATCCCTGTGAATGCTTTTCAGGGACTATGCAATGAAACCTTGACACTGAAGCTGTACAACAATGGCTTTACTTCAGT
CCAAGGATATGCTTTCAATGGGACAAAGCTGGATGCTGTTTACCTAAACAAGAATAAATACCTGACAGTTATTGACAAAGATGCATTTGG
AGGAGTATACAGTGGACCAAGCTTGCTGCTACCTCTTGGAAGAAAGTCCTTGTCCTTTGAGACTCAGAAGGCCCCACGCTCCAGTATGCC
ATCATGATGCCTGCTAAGGCAGCCACCTTGGTGTACATGCTCACAGAGGCTCTGTTCATGGAGCAGCTGCTGTTTGAAAAATTTTGAAAT
GCAAGATCCACAACTAGATGGAAGGCACTCTAGTCTTTGCAGAAAAAAATGTACCTGAATGTACATTGCACAATGCCTGGCACAAAGAAG
GAAGAATATAAATGATAGTTCGACTCGTCTGTGGAAGAACTTACAATCATGGGGAAAGATGGAATAAAAACATTTTTTAAACAGCATGAA

>60951_60951_12_NUMB-TSHR_NUMB_chr14_73822334_ENST00000359560_TSHR_chr14_81528492_ENST00000342443_length(amino acids)=226AA_BP=29
MFMFQRPVVHISGRQMKKAFAPENVASRLRKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYI
DPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYL

--------------------------------------------------------------
>60951_60951_13_NUMB-TSHR_NUMB_chr14_73822334_ENST00000359560_TSHR_chr14_81528492_ENST00000541158_length(transcript)=4479nt_BP=405nt
GCTTGAGTTGGTCGGGGGCAGCGGCAGCTGAGCTGGGATGGGAGACCCAACTGGCCTGGCCGCTCCGGCTCTGAGGATCCCTAAGGGACC
AGGAAAGAAGTCCTCGAGGAGTGGCTCGCGTTTGAGACCGGGATTTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTGCCAGTGCAGCCA
CTGTTACAATTCAAGATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCACTTAGGACAAGCTGTA
AAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACA
GATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGGAAGCTTATTGAGACTCACCTGAGAACTATTCCAAGTCATGCATT
TTCTAATCTGCCCAATATTTCCAGAATCTACGTATCTATAGATGTGACTCTGCAGCAGCTGGAATCACACTCCTTCTACAATTTGAGTAA
AGTGACTCACATAGAAATTCGGAATACCAGGAACTTAACTTACATAGACCCTGATGCCCTCAAAGAGCTCCCCCTCCTAAAGTTCCTTGG
CATTTTCAACACTGGACTTAAAATGTTCCCTGACCTGACCAAAGTTTATTCCACTGATATATTCTTTATACTTGAAATTACAGACAACCC
TTACATGACGTCAATCCCTGTGAATGCTTTTCAGGGACTATGCAATGAAACCTTGACACTGAAGCTGTACAACAATGGCTTTACTTCAGT
CCAAGGATATGCTTTCAATGGGACAAAGCTGGATGCTGTTTACCTAAACAAGAATAAATACCTGACAGTTATTGACAAAGATGCATTTGG
AGGAGTATACAGTGGACCAAGCTTGCTGGACGTGTCTCAAACCAGTGTCACTGCCCTTCCATCCAAAGGCCTGGAGCACCTGAAGGAACT
GATAGCAAGAAACACCTGGACTCTTAAGAAACTTCCACTTTCCTTGAGTTTCCTTCACCTCACACGGGCTGACCTTTCTTACCCAAGCCA
CTGCTGTGCTTTTAAGAATCAGAAGAAAATCAGAGGAATCCTTGAGTCCTTGATGTGTAATGAGAGCAGTATGCAGAGCTTGCGCCAGAG
AAAATCTGTGAATGCCTTGAATAGCCCCCTCCACCAGGAATATGAAGAGAATCTGGGTGACAGCATTGTTGGGTACAAGGAAAAGTCCAA
GTTCCAGGATACTCATAACAACGCTCATTATTACGTCTTCTTTGAAGAACAAGAGGATGAGATCATTGGTTTTGGCCAGGAGCTCAAAAA
CCCCCAGGAAGAGACTCTACAAGCTTTTGACAGCCATTATGACTACACCATATGTGGGGACAGTGAAGACATGGTGTGTACCCCCAAGTC
CGATGAGTTCAACCCGTGTGAAGACATAATGGGCTACAAGTTCCTGAGAATTGTGGTGTGGTTCGTTAGTCTGCTGGCTCTCCTGGGCAA
TGTCTTTGTCCTGCTTATTCTCCTCACCAGCCACTACAAACTGAACGTCCCCCGCTTTCTCATGTGCAACCTGGCCTTTGCGGATTTCTG
CATGGGGATGTACCTGCTCCTCATCGCCTCTGTAGACCTCTACACTCACTCTGAGTACTACAACCATGCCATCGACTGGCAGACAGGCCC
TGGGTGCAACACGGCTGGTTTCTTCACTGTCTTTGCAAGCGAGTTATCGGTGTATACGCTGACGGTCATCACCCTGGAGCGCTGGTATGC
CATCACCTTCGCCATGCGCCTGGACCGGAAGATCCGCCTCAGGCACGCATGTGCCATCATGGTTGGGGGCTGGGTTTGCTGCTTCCTTCT
CGCCCTGCTTCCTTTGGTGGGAATAAGTAGCTATGCCAAAGTCAGTATCTGCCTGCCCATGGACACCGAGACCCCTCTTGCTCTGGCATA
TATTGTTTTTGTTCTGACGCTCAACATAGTTGCCTTCGTCATCGTCTGCTGCTGTTATGTGAAGATCTACATCACAGTCCGAAATCCGCA
GTACAACCCAGGGGACAAAGATACCAAAATTGCCAAGAGGATGGCTGTGTTGATCTTCACCGACTTCATATGCATGGCCCCAATCTCATT
CTATGCTCTGTCAGCAATTCTGAACAAGCCTCTCATCACTGTTAGCAACTCCAAAATCTTGCTGGTACTCTTCTATCCACTTAACTCCTG
TGCCAATCCATTCCTCTATGCTATTTTCACCAAGGCCTTCCAGAGGGATGTGTTCATCCTACTCAGCAAGTTTGGCATCTGTAAACGCCA
GGCTCAGGCATACCGGGGGCAGAGGGTTCCTCCAAAGAACAGCACTGATATTCAGGTTCAAAAGGTTACCCACGAGATGAGGCAGGGTCT
CCACAACATGGAAGATGTCTATGAACTGATTGAAAACTCCCATCTAACCCCAAAGAAGCAAGGCCAAATCTCAGAAGAGTATATGCAAAC
GGTTTTGTAAGTTAACACTACACTACTCACAATGGTAGGGGAACTTACAAAATAATAGTTTCTTGAATATGCATTCCAATCCCATGACAC
CCCCAACACATAGCTGCCCTCACTCTTGTGCAGGCGATGTTTCAATGTTTCATGGGGCAAGAGTTTATCTCTGGAGAGTGATTAGTATTA
ACCTAATCATTGCCCCCAAGAAGGAAGTTAGGCTACCAGCATATTTGAATGCCAGGTGAAATCAAAATAATCTACACTATCTAGAAGACT
TTCTTGATGCCAAGTCCAGAGATGTCATTGTGTAGGATGTTCAGTAAATATTAACTGAGCTATGTCAATATAGAGCTTCTCAGTTTTGTA
TAACATTTCATACTAAAGATTCAGCAAATGGAAAATGCTATTAATTTGGTTGGTGACCACAAGATAAAATCAGTCCCACGTTGGCTCAGT
TCAACTAGATGTTCCCTGATACAAAGAGAACTTGATTTCCTTAAAACTGAAAAGCCAAACACAGCTAGCTGTCATACAAGAAACAGCTAT
TATGAGACATGAAGGAGGGTAAGAATTAGCTTTAAGTTTTGTTTTGCTTTGTTTTGTTTTTTAACTCAACCTATTAATCATCTCTTCACA
AGAATCCACCTGATGTGACCAAGCTATTATGTGTTGCCTGGAAAAACTGGCAAGATTTCAGCTTATGTGGCCTAGCAAACTAAGAATTGC
TCTTCTTGGCCAGCCTCATAGCATAAAAGATGTGAACTCTAGGAAGTCTTTCTGAGTAGCAATAAGTGGGAATTATGGGCAGAGCACACT
CAATCCCCTGTTGATTAATAAAACAGGCTGGACACTAATTAACTATGGGACTTAAATCTGTAGAAATGAAGGAGTCCAATAGCTTCTTCC
AATTTTAAAACTCTAGTACATCCCTTTCCCTCAAATATATATTTCTAAGATAAAGAGAAAGAAGAGCACTAAGTAAGTAGAATCTGTTTT
TCCTATTTTGTAGGGCTGCTGACTCCTAGTCCTTGAAGCCTAGACACATGACCCAGGAAATTTTTCCTTTGTTTCACTTTTGATTATGAT
GTCTGAGCCAAAAATTCAATTAAGTAAACATACTCGCCTGGATCTGAATCATTCATTTAATTACTAGATCTACCCAGCTGTTATATCAGG
CCAAAAACAGATTCGTGTTTATATAAAAGAGTAAACGATGGTTGCAAATTTTGGCTATTTAGAGTTGCTACTTCACTATGAAGAGTCACT
TCAAAACACTTCGCTTGTCTTTAGGGATGATTTTTGCCATTTCCAGTCCACGGTATGATACTAAAGCTGTCAAGAGAGGTTTCTTCTTTT
CTGAAACTGCCAGCTCTTTCCAGCCCTGTTGATCACTGGACATAAAGCTTCTTTTCCCCAATAATTCTTCTTTACTTAAAATAGTCAGGA
TCTTTATCTACAGATGTACTCTCCAGGTTACCTGTGATGATAGCCCCCTAATGTCCTGCTAGAAAAGTCTCCAAGCAGAGATGACATTAC
TTCTGAATGCTCATAAACCACACCATGAAATAAAAGCTCTTTGTTGTTTTAAGATTGTGAAGTGTCGTTAATGGGTCCCCACAGATGGTC
CCTGCTGGACTCACCTGGAATCTCTCCACAGCCATACCCACTCATCACTATCATTGAGACCTGCACATCTTAATAGAAATATTATAAACA
TCGAAAATCATGACTTACCTAGAAGTTCGCTTGTAACTAATGAAATTAAACAAATGTGTTGCCTTTTGTCATGTGTTTCTCTCCTGTGAC
ATTTCAAAATATCACATCTTGATAAATAATGTGTTTCATCTTGAATAGCTGAACTAATTGCTTTGGAAACAGAGTCCTAGAAAAGTGACT

>60951_60951_13_NUMB-TSHR_NUMB_chr14_73822334_ENST00000359560_TSHR_chr14_81528492_ENST00000541158_length(amino acids)=737AA_BP=29
MFMFQRPVVHISGRQMKKAFAPENVASRLRKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYI
DPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYL
NKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILE
SLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDY
TICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYT
HSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVS
ICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVS
NSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHEMRQGLHNMEDVYELIENSHL

--------------------------------------------------------------
>60951_60951_14_NUMB-TSHR_NUMB_chr14_73822334_ENST00000359560_TSHR_chr14_81528492_ENST00000554263_length(transcript)=1393nt_BP=405nt
GCTTGAGTTGGTCGGGGGCAGCGGCAGCTGAGCTGGGATGGGAGACCCAACTGGCCTGGCCGCTCCGGCTCTGAGGATCCCTAAGGGACC
AGGAAAGAAGTCCTCGAGGAGTGGCTCGCGTTTGAGACCGGGATTTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTGCCAGTGCAGCCA
CTGTTACAATTCAAGATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCACTTAGGACAAGCTGTA
AAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACA
GATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGGAAGCTTATTGAGACTCACCTGAGAACTATTCCAAGTCATGCATT
TTCTAATCTGCCCAATATTTCCAGAATCTACGTATCTATAGATGTGACTCTGCAGCAGCTGGAATCACACTCCTTCTACAATTTGAGTAA
AGTGACTCACATAGAAATTCGGAATACCAGGAACTTAACTTACATAGACCCTGATGCCCTCAAAGAGCTCCCCCTCCTAAAGTTCCTTGG
CATTTTCAACACTGGACTTAAAATGTTCCCTGACCTGACCAAAGTTTATTCCACTGATATATTCTTTATACTTGAAATTACAGACAACCC
TTACATGACGTCAATCCCTGTGAATGCTTTTCAGGGACTATGCAATGAAACCTTGACACTGAAGCTGTACAACAATGGCTTTACTTCAGT
CCAAGGATATGCTTTCAATGGGACAAAGCTGGATGCTGTTTACCTAAACAAGAATAAATACCTGACAGTTATTGACAAAGATGCATTTGG
AGGAGTATACAGTGGACCAAGCTTGCTGTGAGTAAGACATACAAAAGAATATTTTAGTCTTTTTTTTTCTTTTTTTTTTTTTGGAATAAA
TGGAGACATTAAGGGGAGAATCTTATGTTCAAGGGTAGAAAATGTTGCTGTCTCGGGTAAAGGCTTCTGCAAGTCCCTCTTTTCCTGGCT
GTATAGGCTACCTCTTGGAAGAAAGTCCTTGTCCTTTGAGACTCAGAAGGCCCCACGCTCCAGTATGCCATCATGATGCCTGCTAAGGCA
GCCACCTTGGTGTACATGCTCACAGAGGCTCTGTTCATGGAGCAGCTGCTGTTTGAAAAATTTTGAAATGCAAGATCCACAACTAGATGG
AAGGCACTCTAGTCTTTGCAGAAAAAAATGTACCTGAATGTACATTGCACAATGCCTGGCACAAAGAAGGAAGAATATAAATGATAGTTC

>60951_60951_14_NUMB-TSHR_NUMB_chr14_73822334_ENST00000359560_TSHR_chr14_81528492_ENST00000554263_length(amino acids)=204AA_BP=29
MFMFQRPVVHISGRQMKKAFAPENVASRLRKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYI
DPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYL

--------------------------------------------------------------
>60951_60951_15_NUMB-TSHR_NUMB_chr14_73822334_ENST00000359560_TSHR_chr14_81528492_ENST00000554435_length(transcript)=1298nt_BP=405nt
GCTTGAGTTGGTCGGGGGCAGCGGCAGCTGAGCTGGGATGGGAGACCCAACTGGCCTGGCCGCTCCGGCTCTGAGGATCCCTAAGGGACC
AGGAAAGAAGTCCTCGAGGAGTGGCTCGCGTTTGAGACCGGGATTTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTGCCAGTGCAGCCA
CTGTTACAATTCAAGATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCACTTAGGACAAGCTGTA
AAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACATCAGTGGCAGACA
GATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGGAAGCTTATTGAGACTCACCTGAGAACTATTCCAAGTCATGCATT
TTCTAATCTGCCCAATATTTCCAGAATCTACGTATCTATAGATGTGACTCTGCAGCAGCTGGAATCACACTCCTTCTACAATTTGAGTAA
AGTGACTCACATAGAAATTCGGAATACCAGGAACTTAACTTACATAGACCCTGATGCCCTCAAAGAGCTCCCCCTCCTAAAGTTCCTTGG
CATTTTCAACACTGGACTTAAAATGTTCCCTGACCTGACCAAAGTTTATTCCACTGATATATTCTTTATACTTGAAATTACAGACAACCC
TTACATGACGTCAATCCCTGTGAATGCTTTTCAGGGACTATGCAATGAAACCTTGACACTGAAGCTGTACAACAATGGCTTTACTTCAGT
CCAAGGATATGCTTTCAATGGGACAAAGCTGGATGCTGTTTACCTAAACAAGAATAAATACCTGACAGTTATTGACAAAGATGCATTTGG
AGGAGTATACAGTGGACCAAGCTTGCTGGTAGAAAATGTTGCTGTCTCGGGTAAAGGCTTCTGCAAGTCCCTCTTTTCCTGGCTGTATAG
GCTACCTCTTGGAAGAAAGTCCTTGTCCTTTGAGACTCAGAAGGCCCCACGCTCCAGTATGCCATCATGATGCCTGCTAAGGCAGCCACC
TTGGTGTACATGCTCACAGAGGCTCTGTTCATGGAGCAGCTGCTGTTTGAAAAATTTTGAAATGCAAGATCCACAACTAGATGGAAGGCA
CTCTAGTCTTTGCAGAAAAAAATGTACCTGAATGTACATTGCACAATGCCTGGCACAAAGAAGGAAGAATATAAATGATAGTTCGACTCG

>60951_60951_15_NUMB-TSHR_NUMB_chr14_73822334_ENST00000359560_TSHR_chr14_81528492_ENST00000554435_length(amino acids)=247AA_BP=29
MFMFQRPVVHISGRQMKKAFAPENVASRLRKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYI
DPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYL

--------------------------------------------------------------
>60951_60951_16_NUMB-TSHR_NUMB_chr14_73822334_ENST00000535282_TSHR_chr14_81528492_ENST00000298171_length(transcript)=4401nt_BP=327nt
ACTGGCGGCCGAGGTAGAGGCAGTGGCGCTTGAGTTGGTCGGGGGCAGCGGCAGATTTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTG
CCAGTGCAGCCACTGTTACAATTCAAGATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCACTTA
GGACAAGCTGTAAAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACAT
CAGTGGCAGACAGATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGGAAGCTTATTGAGACTCACCTGAGAACTATTCC
AAGTCATGCATTTTCTAATCTGCCCAATATTTCCAGAATCTACGTATCTATAGATGTGACTCTGCAGCAGCTGGAATCACACTCCTTCTA
CAATTTGAGTAAAGTGACTCACATAGAAATTCGGAATACCAGGAACTTAACTTACATAGACCCTGATGCCCTCAAAGAGCTCCCCCTCCT
AAAGTTCCTTGGCATTTTCAACACTGGACTTAAAATGTTCCCTGACCTGACCAAAGTTTATTCCACTGATATATTCTTTATACTTGAAAT
TACAGACAACCCTTACATGACGTCAATCCCTGTGAATGCTTTTCAGGGACTATGCAATGAAACCTTGACACTGAAGCTGTACAACAATGG
CTTTACTTCAGTCCAAGGATATGCTTTCAATGGGACAAAGCTGGATGCTGTTTACCTAAACAAGAATAAATACCTGACAGTTATTGACAA
AGATGCATTTGGAGGAGTATACAGTGGACCAAGCTTGCTGGACGTGTCTCAAACCAGTGTCACTGCCCTTCCATCCAAAGGCCTGGAGCA
CCTGAAGGAACTGATAGCAAGAAACACCTGGACTCTTAAGAAACTTCCACTTTCCTTGAGTTTCCTTCACCTCACACGGGCTGACCTTTC
TTACCCAAGCCACTGCTGTGCTTTTAAGAATCAGAAGAAAATCAGAGGAATCCTTGAGTCCTTGATGTGTAATGAGAGCAGTATGCAGAG
CTTGCGCCAGAGAAAATCTGTGAATGCCTTGAATAGCCCCCTCCACCAGGAATATGAAGAGAATCTGGGTGACAGCATTGTTGGGTACAA
GGAAAAGTCCAAGTTCCAGGATACTCATAACAACGCTCATTATTACGTCTTCTTTGAAGAACAAGAGGATGAGATCATTGGTTTTGGCCA
GGAGCTCAAAAACCCCCAGGAAGAGACTCTACAAGCTTTTGACAGCCATTATGACTACACCATATGTGGGGACAGTGAAGACATGGTGTG
TACCCCCAAGTCCGATGAGTTCAACCCGTGTGAAGACATAATGGGCTACAAGTTCCTGAGAATTGTGGTGTGGTTCGTTAGTCTGCTGGC
TCTCCTGGGCAATGTCTTTGTCCTGCTTATTCTCCTCACCAGCCACTACAAACTGAACGTCCCCCGCTTTCTCATGTGCAACCTGGCCTT
TGCGGATTTCTGCATGGGGATGTACCTGCTCCTCATCGCCTCTGTAGACCTCTACACTCACTCTGAGTACTACAACCATGCCATCGACTG
GCAGACAGGCCCTGGGTGCAACACGGCTGGTTTCTTCACTGTCTTTGCAAGCGAGTTATCGGTGTATACGCTGACGGTCATCACCCTGGA
GCGCTGGTATGCCATCACCTTCGCCATGCGCCTGGACCGGAAGATCCGCCTCAGGCACGCATGTGCCATCATGGTTGGGGGCTGGGTTTG
CTGCTTCCTTCTCGCCCTGCTTCCTTTGGTGGGAATAAGTAGCTATGCCAAAGTCAGTATCTGCCTGCCCATGGACACCGAGACCCCTCT
TGCTCTGGCATATATTGTTTTTGTTCTGACGCTCAACATAGTTGCCTTCGTCATCGTCTGCTGCTGTTATGTGAAGATCTACATCACAGT
CCGAAATCCGCAGTACAACCCAGGGGACAAAGATACCAAAATTGCCAAGAGGATGGCTGTGTTGATCTTCACCGACTTCATATGCATGGC
CCCAATCTCATTCTATGCTCTGTCAGCAATTCTGAACAAGCCTCTCATCACTGTTAGCAACTCCAAAATCTTGCTGGTACTCTTCTATCC
ACTTAACTCCTGTGCCAATCCATTCCTCTATGCTATTTTCACCAAGGCCTTCCAGAGGGATGTGTTCATCCTACTCAGCAAGTTTGGCAT
CTGTAAACGCCAGGCTCAGGCATACCGGGGGCAGAGGGTTCCTCCAAAGAACAGCACTGATATTCAGGTTCAAAAGGTTACCCACGAGAT
GAGGCAGGGTCTCCACAACATGGAAGATGTCTATGAACTGATTGAAAACTCCCATCTAACCCCAAAGAAGCAAGGCCAAATCTCAGAAGA
GTATATGCAAACGGTTTTGTAAGTTAACACTACACTACTCACAATGGTAGGGGAACTTACAAAATAATAGTTTCTTGAATATGCATTCCA
ATCCCATGACACCCCCAACACATAGCTGCCCTCACTCTTGTGCAGGCGATGTTTCAATGTTTCATGGGGCAAGAGTTTATCTCTGGAGAG
TGATTAGTATTAACCTAATCATTGCCCCCAAGAAGGAAGTTAGGCTACCAGCATATTTGAATGCCAGGTGAAATCAAAATAATCTACACT
ATCTAGAAGACTTTCTTGATGCCAAGTCCAGAGATGTCATTGTGTAGGATGTTCAGTAAATATTAACTGAGCTATGTCAATATAGAGCTT
CTCAGTTTTGTATAACATTTCATACTAAAGATTCAGCAAATGGAAAATGCTATTAATTTGGTTGGTGACCACAAGATAAAATCAGTCCCA
CGTTGGCTCAGTTCAACTAGATGTTCCCTGATACAAAGAGAACTTGATTTCCTTAAAACTGAAAAGCCAAACACAGCTAGCTGTCATACA
AGAAACAGCTATTATGAGACATGAAGGAGGGTAAGAATTAGCTTTAAGTTTTGTTTTGCTTTGTTTTGTTTTTTAACTCAACCTATTAAT
CATCTCTTCACAAGAATCCACCTGATGTGACCAAGCTATTATGTGTTGCCTGGAAAAACTGGCAAGATTTCAGCTTATGTGGCCTAGCAA
ACTAAGAATTGCTCTTCTTGGCCAGCCTCATAGCATAAAAGATGTGAACTCTAGGAAGTCTTTCTGAGTAGCAATAAGTGGGAATTATGG
GCAGAGCACACTCAATCCCCTGTTGATTAATAAAACAGGCTGGACACTAATTAACTATGGGACTTAAATCTGTAGAAATGAAGGAGTCCA
ATAGCTTCTTCCAATTTTAAAACTCTAGTACATCCCTTTCCCTCAAATATATATTTCTAAGATAAAGAGAAAGAAGAGCACTAAGTAAGT
AGAATCTGTTTTTCCTATTTTGTAGGGCTGCTGACTCCTAGTCCTTGAAGCCTAGACACATGACCCAGGAAATTTTTCCTTTGTTTCACT
TTTGATTATGATGTCTGAGCCAAAAATTCAATTAAGTAAACATACTCGCCTGGATCTGAATCATTCATTTAATTACTAGATCTACCCAGC
TGTTATATCAGGCCAAAAACAGATTCGTGTTTATATAAAAGAGTAAACGATGGTTGCAAATTTTGGCTATTTAGAGTTGCTACTTCACTA
TGAAGAGTCACTTCAAAACACTTCGCTTGTCTTTAGGGATGATTTTTGCCATTTCCAGTCCACGGTATGATACTAAAGCTGTCAAGAGAG
GTTTCTTCTTTTCTGAAACTGCCAGCTCTTTCCAGCCCTGTTGATCACTGGACATAAAGCTTCTTTTCCCCAATAATTCTTCTTTACTTA
AAATAGTCAGGATCTTTATCTACAGATGTACTCTCCAGGTTACCTGTGATGATAGCCCCCTAATGTCCTGCTAGAAAAGTCTCCAAGCAG
AGATGACATTACTTCTGAATGCTCATAAACCACACCATGAAATAAAAGCTCTTTGTTGTTTTAAGATTGTGAAGTGTCGTTAATGGGTCC
CCACAGATGGTCCCTGCTGGACTCACCTGGAATCTCTCCACAGCCATACCCACTCATCACTATCATTGAGACCTGCACATCTTAATAGAA
ATATTATAAACATCGAAAATCATGACTTACCTAGAAGTTCGCTTGTAACTAATGAAATTAAACAAATGTGTTGCCTTTTGTCATGTGTTT
CTCTCCTGTGACATTTCAAAATATCACATCTTGATAAATAATGTGTTTCATCTTGAATAGCTGAACTAATTGCTTTGGAAACAGAGTCCT

>60951_60951_16_NUMB-TSHR_NUMB_chr14_73822334_ENST00000535282_TSHR_chr14_81528492_ENST00000298171_length(amino acids)=737AA_BP=29
MFMFQRPVVHISGRQMKKAFAPENVASRLRKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYI
DPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYL
NKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILE
SLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDY
TICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYT
HSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVS
ICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVS
NSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHEMRQGLHNMEDVYELIENSHL

--------------------------------------------------------------
>60951_60951_17_NUMB-TSHR_NUMB_chr14_73822334_ENST00000535282_TSHR_chr14_81528492_ENST00000342443_length(transcript)=1188nt_BP=327nt
ACTGGCGGCCGAGGTAGAGGCAGTGGCGCTTGAGTTGGTCGGGGGCAGCGGCAGATTTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTG
CCAGTGCAGCCACTGTTACAATTCAAGATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCACTTA
GGACAAGCTGTAAAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACAT
CAGTGGCAGACAGATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGGAAGCTTATTGAGACTCACCTGAGAACTATTCC
AAGTCATGCATTTTCTAATCTGCCCAATATTTCCAGAATCTACGTATCTATAGATGTGACTCTGCAGCAGCTGGAATCACACTCCTTCTA
CAATTTGAGTAAAGTGACTCACATAGAAATTCGGAATACCAGGAACTTAACTTACATAGACCCTGATGCCCTCAAAGAGCTCCCCCTCCT
AAAGTTCCTTGGCATTTTCAACACTGGACTTAAAATGTTCCCTGACCTGACCAAAGTTTATTCCACTGATATATTCTTTATACTTGAAAT
TACAGACAACCCTTACATGACGTCAATCCCTGTGAATGCTTTTCAGGGACTATGCAATGAAACCTTGACACTGAAGCTGTACAACAATGG
CTTTACTTCAGTCCAAGGATATGCTTTCAATGGGACAAAGCTGGATGCTGTTTACCTAAACAAGAATAAATACCTGACAGTTATTGACAA
AGATGCATTTGGAGGAGTATACAGTGGACCAAGCTTGCTGCTACCTCTTGGAAGAAAGTCCTTGTCCTTTGAGACTCAGAAGGCCCCACG
CTCCAGTATGCCATCATGATGCCTGCTAAGGCAGCCACCTTGGTGTACATGCTCACAGAGGCTCTGTTCATGGAGCAGCTGCTGTTTGAA
AAATTTTGAAATGCAAGATCCACAACTAGATGGAAGGCACTCTAGTCTTTGCAGAAAAAAATGTACCTGAATGTACATTGCACAATGCCT
GGCACAAAGAAGGAAGAATATAAATGATAGTTCGACTCGTCTGTGGAAGAACTTACAATCATGGGGAAAGATGGAATAAAAACATTTTTT

>60951_60951_17_NUMB-TSHR_NUMB_chr14_73822334_ENST00000535282_TSHR_chr14_81528492_ENST00000342443_length(amino acids)=226AA_BP=29
MFMFQRPVVHISGRQMKKAFAPENVASRLRKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYI
DPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYL

--------------------------------------------------------------
>60951_60951_18_NUMB-TSHR_NUMB_chr14_73822334_ENST00000535282_TSHR_chr14_81528492_ENST00000541158_length(transcript)=4401nt_BP=327nt
ACTGGCGGCCGAGGTAGAGGCAGTGGCGCTTGAGTTGGTCGGGGGCAGCGGCAGATTTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTG
CCAGTGCAGCCACTGTTACAATTCAAGATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCACTTA
GGACAAGCTGTAAAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACAT
CAGTGGCAGACAGATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGGAAGCTTATTGAGACTCACCTGAGAACTATTCC
AAGTCATGCATTTTCTAATCTGCCCAATATTTCCAGAATCTACGTATCTATAGATGTGACTCTGCAGCAGCTGGAATCACACTCCTTCTA
CAATTTGAGTAAAGTGACTCACATAGAAATTCGGAATACCAGGAACTTAACTTACATAGACCCTGATGCCCTCAAAGAGCTCCCCCTCCT
AAAGTTCCTTGGCATTTTCAACACTGGACTTAAAATGTTCCCTGACCTGACCAAAGTTTATTCCACTGATATATTCTTTATACTTGAAAT
TACAGACAACCCTTACATGACGTCAATCCCTGTGAATGCTTTTCAGGGACTATGCAATGAAACCTTGACACTGAAGCTGTACAACAATGG
CTTTACTTCAGTCCAAGGATATGCTTTCAATGGGACAAAGCTGGATGCTGTTTACCTAAACAAGAATAAATACCTGACAGTTATTGACAA
AGATGCATTTGGAGGAGTATACAGTGGACCAAGCTTGCTGGACGTGTCTCAAACCAGTGTCACTGCCCTTCCATCCAAAGGCCTGGAGCA
CCTGAAGGAACTGATAGCAAGAAACACCTGGACTCTTAAGAAACTTCCACTTTCCTTGAGTTTCCTTCACCTCACACGGGCTGACCTTTC
TTACCCAAGCCACTGCTGTGCTTTTAAGAATCAGAAGAAAATCAGAGGAATCCTTGAGTCCTTGATGTGTAATGAGAGCAGTATGCAGAG
CTTGCGCCAGAGAAAATCTGTGAATGCCTTGAATAGCCCCCTCCACCAGGAATATGAAGAGAATCTGGGTGACAGCATTGTTGGGTACAA
GGAAAAGTCCAAGTTCCAGGATACTCATAACAACGCTCATTATTACGTCTTCTTTGAAGAACAAGAGGATGAGATCATTGGTTTTGGCCA
GGAGCTCAAAAACCCCCAGGAAGAGACTCTACAAGCTTTTGACAGCCATTATGACTACACCATATGTGGGGACAGTGAAGACATGGTGTG
TACCCCCAAGTCCGATGAGTTCAACCCGTGTGAAGACATAATGGGCTACAAGTTCCTGAGAATTGTGGTGTGGTTCGTTAGTCTGCTGGC
TCTCCTGGGCAATGTCTTTGTCCTGCTTATTCTCCTCACCAGCCACTACAAACTGAACGTCCCCCGCTTTCTCATGTGCAACCTGGCCTT
TGCGGATTTCTGCATGGGGATGTACCTGCTCCTCATCGCCTCTGTAGACCTCTACACTCACTCTGAGTACTACAACCATGCCATCGACTG
GCAGACAGGCCCTGGGTGCAACACGGCTGGTTTCTTCACTGTCTTTGCAAGCGAGTTATCGGTGTATACGCTGACGGTCATCACCCTGGA
GCGCTGGTATGCCATCACCTTCGCCATGCGCCTGGACCGGAAGATCCGCCTCAGGCACGCATGTGCCATCATGGTTGGGGGCTGGGTTTG
CTGCTTCCTTCTCGCCCTGCTTCCTTTGGTGGGAATAAGTAGCTATGCCAAAGTCAGTATCTGCCTGCCCATGGACACCGAGACCCCTCT
TGCTCTGGCATATATTGTTTTTGTTCTGACGCTCAACATAGTTGCCTTCGTCATCGTCTGCTGCTGTTATGTGAAGATCTACATCACAGT
CCGAAATCCGCAGTACAACCCAGGGGACAAAGATACCAAAATTGCCAAGAGGATGGCTGTGTTGATCTTCACCGACTTCATATGCATGGC
CCCAATCTCATTCTATGCTCTGTCAGCAATTCTGAACAAGCCTCTCATCACTGTTAGCAACTCCAAAATCTTGCTGGTACTCTTCTATCC
ACTTAACTCCTGTGCCAATCCATTCCTCTATGCTATTTTCACCAAGGCCTTCCAGAGGGATGTGTTCATCCTACTCAGCAAGTTTGGCAT
CTGTAAACGCCAGGCTCAGGCATACCGGGGGCAGAGGGTTCCTCCAAAGAACAGCACTGATATTCAGGTTCAAAAGGTTACCCACGAGAT
GAGGCAGGGTCTCCACAACATGGAAGATGTCTATGAACTGATTGAAAACTCCCATCTAACCCCAAAGAAGCAAGGCCAAATCTCAGAAGA
GTATATGCAAACGGTTTTGTAAGTTAACACTACACTACTCACAATGGTAGGGGAACTTACAAAATAATAGTTTCTTGAATATGCATTCCA
ATCCCATGACACCCCCAACACATAGCTGCCCTCACTCTTGTGCAGGCGATGTTTCAATGTTTCATGGGGCAAGAGTTTATCTCTGGAGAG
TGATTAGTATTAACCTAATCATTGCCCCCAAGAAGGAAGTTAGGCTACCAGCATATTTGAATGCCAGGTGAAATCAAAATAATCTACACT
ATCTAGAAGACTTTCTTGATGCCAAGTCCAGAGATGTCATTGTGTAGGATGTTCAGTAAATATTAACTGAGCTATGTCAATATAGAGCTT
CTCAGTTTTGTATAACATTTCATACTAAAGATTCAGCAAATGGAAAATGCTATTAATTTGGTTGGTGACCACAAGATAAAATCAGTCCCA
CGTTGGCTCAGTTCAACTAGATGTTCCCTGATACAAAGAGAACTTGATTTCCTTAAAACTGAAAAGCCAAACACAGCTAGCTGTCATACA
AGAAACAGCTATTATGAGACATGAAGGAGGGTAAGAATTAGCTTTAAGTTTTGTTTTGCTTTGTTTTGTTTTTTAACTCAACCTATTAAT
CATCTCTTCACAAGAATCCACCTGATGTGACCAAGCTATTATGTGTTGCCTGGAAAAACTGGCAAGATTTCAGCTTATGTGGCCTAGCAA
ACTAAGAATTGCTCTTCTTGGCCAGCCTCATAGCATAAAAGATGTGAACTCTAGGAAGTCTTTCTGAGTAGCAATAAGTGGGAATTATGG
GCAGAGCACACTCAATCCCCTGTTGATTAATAAAACAGGCTGGACACTAATTAACTATGGGACTTAAATCTGTAGAAATGAAGGAGTCCA
ATAGCTTCTTCCAATTTTAAAACTCTAGTACATCCCTTTCCCTCAAATATATATTTCTAAGATAAAGAGAAAGAAGAGCACTAAGTAAGT
AGAATCTGTTTTTCCTATTTTGTAGGGCTGCTGACTCCTAGTCCTTGAAGCCTAGACACATGACCCAGGAAATTTTTCCTTTGTTTCACT
TTTGATTATGATGTCTGAGCCAAAAATTCAATTAAGTAAACATACTCGCCTGGATCTGAATCATTCATTTAATTACTAGATCTACCCAGC
TGTTATATCAGGCCAAAAACAGATTCGTGTTTATATAAAAGAGTAAACGATGGTTGCAAATTTTGGCTATTTAGAGTTGCTACTTCACTA
TGAAGAGTCACTTCAAAACACTTCGCTTGTCTTTAGGGATGATTTTTGCCATTTCCAGTCCACGGTATGATACTAAAGCTGTCAAGAGAG
GTTTCTTCTTTTCTGAAACTGCCAGCTCTTTCCAGCCCTGTTGATCACTGGACATAAAGCTTCTTTTCCCCAATAATTCTTCTTTACTTA
AAATAGTCAGGATCTTTATCTACAGATGTACTCTCCAGGTTACCTGTGATGATAGCCCCCTAATGTCCTGCTAGAAAAGTCTCCAAGCAG
AGATGACATTACTTCTGAATGCTCATAAACCACACCATGAAATAAAAGCTCTTTGTTGTTTTAAGATTGTGAAGTGTCGTTAATGGGTCC
CCACAGATGGTCCCTGCTGGACTCACCTGGAATCTCTCCACAGCCATACCCACTCATCACTATCATTGAGACCTGCACATCTTAATAGAA
ATATTATAAACATCGAAAATCATGACTTACCTAGAAGTTCGCTTGTAACTAATGAAATTAAACAAATGTGTTGCCTTTTGTCATGTGTTT
CTCTCCTGTGACATTTCAAAATATCACATCTTGATAAATAATGTGTTTCATCTTGAATAGCTGAACTAATTGCTTTGGAAACAGAGTCCT

>60951_60951_18_NUMB-TSHR_NUMB_chr14_73822334_ENST00000535282_TSHR_chr14_81528492_ENST00000541158_length(amino acids)=737AA_BP=29
MFMFQRPVVHISGRQMKKAFAPENVASRLRKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYI
DPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYL
NKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILE
SLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDY
TICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYT
HSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVS
ICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVS
NSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHEMRQGLHNMEDVYELIENSHL

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>60951_60951_19_NUMB-TSHR_NUMB_chr14_73822334_ENST00000535282_TSHR_chr14_81528492_ENST00000554263_length(transcript)=1315nt_BP=327nt
ACTGGCGGCCGAGGTAGAGGCAGTGGCGCTTGAGTTGGTCGGGGGCAGCGGCAGATTTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTG
CCAGTGCAGCCACTGTTACAATTCAAGATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCACTTA
GGACAAGCTGTAAAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACAT
CAGTGGCAGACAGATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGGAAGCTTATTGAGACTCACCTGAGAACTATTCC
AAGTCATGCATTTTCTAATCTGCCCAATATTTCCAGAATCTACGTATCTATAGATGTGACTCTGCAGCAGCTGGAATCACACTCCTTCTA
CAATTTGAGTAAAGTGACTCACATAGAAATTCGGAATACCAGGAACTTAACTTACATAGACCCTGATGCCCTCAAAGAGCTCCCCCTCCT
AAAGTTCCTTGGCATTTTCAACACTGGACTTAAAATGTTCCCTGACCTGACCAAAGTTTATTCCACTGATATATTCTTTATACTTGAAAT
TACAGACAACCCTTACATGACGTCAATCCCTGTGAATGCTTTTCAGGGACTATGCAATGAAACCTTGACACTGAAGCTGTACAACAATGG
CTTTACTTCAGTCCAAGGATATGCTTTCAATGGGACAAAGCTGGATGCTGTTTACCTAAACAAGAATAAATACCTGACAGTTATTGACAA
AGATGCATTTGGAGGAGTATACAGTGGACCAAGCTTGCTGTGAGTAAGACATACAAAAGAATATTTTAGTCTTTTTTTTTCTTTTTTTTT
TTTTGGAATAAATGGAGACATTAAGGGGAGAATCTTATGTTCAAGGGTAGAAAATGTTGCTGTCTCGGGTAAAGGCTTCTGCAAGTCCCT
CTTTTCCTGGCTGTATAGGCTACCTCTTGGAAGAAAGTCCTTGTCCTTTGAGACTCAGAAGGCCCCACGCTCCAGTATGCCATCATGATG
CCTGCTAAGGCAGCCACCTTGGTGTACATGCTCACAGAGGCTCTGTTCATGGAGCAGCTGCTGTTTGAAAAATTTTGAAATGCAAGATCC
ACAACTAGATGGAAGGCACTCTAGTCTTTGCAGAAAAAAATGTACCTGAATGTACATTGCACAATGCCTGGCACAAAGAAGGAAGAATAT

>60951_60951_19_NUMB-TSHR_NUMB_chr14_73822334_ENST00000535282_TSHR_chr14_81528492_ENST00000554263_length(amino acids)=204AA_BP=29
MFMFQRPVVHISGRQMKKAFAPENVASRLRKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYI
DPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYL

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>60951_60951_20_NUMB-TSHR_NUMB_chr14_73822334_ENST00000535282_TSHR_chr14_81528492_ENST00000554435_length(transcript)=1220nt_BP=327nt
ACTGGCGGCCGAGGTAGAGGCAGTGGCGCTTGAGTTGGTCGGGGGCAGCGGCAGATTTGAGGCTTAAGCAACTTCTTCCGGGGAAGAGTG
CCAGTGCAGCCACTGTTACAATTCAAGATCTTGATCTATATCCATAGATTGGAATATTGGTGGGCCAGCAATCCTCAGACGCCTCACTTA
GGACAAGCTGTAAAAATTAAAATGAACAAATTACGGCAAAGTTTTAGGAGAAAGAAGGATGTTTATGTTCCAGAGGCCAGTCGTCCACAT
CAGTGGCAGACAGATGAAGAAGGCGTTCGCACCGGAAAATGTAGCTTCCCGGTTAAGGAAGCTTATTGAGACTCACCTGAGAACTATTCC
AAGTCATGCATTTTCTAATCTGCCCAATATTTCCAGAATCTACGTATCTATAGATGTGACTCTGCAGCAGCTGGAATCACACTCCTTCTA
CAATTTGAGTAAAGTGACTCACATAGAAATTCGGAATACCAGGAACTTAACTTACATAGACCCTGATGCCCTCAAAGAGCTCCCCCTCCT
AAAGTTCCTTGGCATTTTCAACACTGGACTTAAAATGTTCCCTGACCTGACCAAAGTTTATTCCACTGATATATTCTTTATACTTGAAAT
TACAGACAACCCTTACATGACGTCAATCCCTGTGAATGCTTTTCAGGGACTATGCAATGAAACCTTGACACTGAAGCTGTACAACAATGG
CTTTACTTCAGTCCAAGGATATGCTTTCAATGGGACAAAGCTGGATGCTGTTTACCTAAACAAGAATAAATACCTGACAGTTATTGACAA
AGATGCATTTGGAGGAGTATACAGTGGACCAAGCTTGCTGGTAGAAAATGTTGCTGTCTCGGGTAAAGGCTTCTGCAAGTCCCTCTTTTC
CTGGCTGTATAGGCTACCTCTTGGAAGAAAGTCCTTGTCCTTTGAGACTCAGAAGGCCCCACGCTCCAGTATGCCATCATGATGCCTGCT
AAGGCAGCCACCTTGGTGTACATGCTCACAGAGGCTCTGTTCATGGAGCAGCTGCTGTTTGAAAAATTTTGAAATGCAAGATCCACAACT
AGATGGAAGGCACTCTAGTCTTTGCAGAAAAAAATGTACCTGAATGTACATTGCACAATGCCTGGCACAAAGAAGGAAGAATATAAATGA

>60951_60951_20_NUMB-TSHR_NUMB_chr14_73822334_ENST00000535282_TSHR_chr14_81528492_ENST00000554435_length(amino acids)=247AA_BP=29
MFMFQRPVVHISGRQMKKAFAPENVASRLRKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYI
DPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYL

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Fusion Gene PPI Analysis for NUMB-TSHR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NUMB-TSHR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NUMB-TSHR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource