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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NUP153-MAK (FusionGDB2 ID:60975)

Fusion Gene Summary for NUP153-MAK

check button Fusion gene summary
Fusion gene informationFusion gene name: NUP153-MAK
Fusion gene ID: 60975
HgeneTgene
Gene symbol

NUP153

MAK

Gene ID

9972

57538

Gene namenucleoporin 153alpha kinase 3
SynonymsHNUP153|N153CMH27|MAK|MIDORI
Cytomap

6p22.3

15q25.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear pore complex protein Nup153153 kDa nucleoporinnuclear pore complex protein hnup153nucleoporin 153kDnucleoporin 153kDanucleoporin Nup153alpha-protein kinase 3muscle alpha-kinasemuscle alpha-protein kinasemyocyte induction differentiation originator
Modification date2020031320200313
UniProtAcc.

Q9BXY0

Ensembl transtripts involved in fusion geneENST00000262077, ENST00000537253, 
ENST00000313243, ENST00000354489, 
ENST00000474039, ENST00000536370, 
ENST00000538030, 
Fusion gene scores* DoF score14 X 11 X 10=15404 X 4 X 4=64
# samples 164
** MAII scorelog2(16/1540*10)=-3.2667865406949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NUP153 [Title/Abstract] AND MAK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNUP153(17675136)-MAK(10819173), # samples:1
Anticipated loss of major functional domain due to fusion event.NUP153-MAK seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NUP153-MAK seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NUP153-MAK seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
NUP153-MAK seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNUP153

GO:0046832

negative regulation of RNA export from nucleus

22253824


check buttonFusion gene breakpoints across NUP153 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DH-A66G-01ANUP153chr6

17675136

-MAKchr6

10819173

-


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Fusion Gene ORF analysis for NUP153-MAK

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000262077ENST00000313243NUP153chr6

17675136

-MAKchr6

10819173

-
Frame-shiftENST00000262077ENST00000354489NUP153chr6

17675136

-MAKchr6

10819173

-
Frame-shiftENST00000262077ENST00000474039NUP153chr6

17675136

-MAKchr6

10819173

-
Frame-shiftENST00000537253ENST00000313243NUP153chr6

17675136

-MAKchr6

10819173

-
Frame-shiftENST00000537253ENST00000354489NUP153chr6

17675136

-MAKchr6

10819173

-
Frame-shiftENST00000537253ENST00000474039NUP153chr6

17675136

-MAKchr6

10819173

-
In-frameENST00000262077ENST00000536370NUP153chr6

17675136

-MAKchr6

10819173

-
In-frameENST00000262077ENST00000538030NUP153chr6

17675136

-MAKchr6

10819173

-
In-frameENST00000537253ENST00000536370NUP153chr6

17675136

-MAKchr6

10819173

-
In-frameENST00000537253ENST00000538030NUP153chr6

17675136

-MAKchr6

10819173

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262077NUP153chr617675136-ENST00000538030MAKchr610819173-29798528532124423
ENST00000262077NUP153chr617675136-ENST00000536370MAKchr610819173-22938520881293
ENST00000537253NUP153chr617675136-ENST00000538030MAKchr610819173-30178908912162423
ENST00000537253NUP153chr617675136-ENST00000536370MAKchr610819173-233189038919293

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262077ENST00000538030NUP153chr617675136-MAKchr610819173-0.0016436520.9983563
ENST00000262077ENST00000536370NUP153chr617675136-MAKchr610819173-0.0031664920.9968335
ENST00000537253ENST00000538030NUP153chr617675136-MAKchr610819173-0.0016632340.9983368
ENST00000537253ENST00000536370NUP153chr617675136-MAKchr610819173-0.0032031430.9967969

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Fusion Genomic Features for NUP153-MAK


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NUP153-MAK


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:17675136/chr6:10819173)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MAK

Q9BXY0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-5224_142841476.0Compositional biasNote=Gly-rich
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-522236_2372841476.0Repeat1
TgeneMAKchr6:17675136chr6:10819173ENST00000313243114309_36833624.0Compositional biasNote=Glu/Pro-rich
TgeneMAKchr6:17675136chr6:10819173ENST00000354489013309_36833624.0Compositional biasNote=Glu/Pro-rich
TgeneMAKchr6:17675136chr6:10819173ENST00000474039114309_36833624.0Compositional biasNote=Glu/Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-522443_4472841476.0Compositional biasNote=Poly-Gly
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-5221350_14752841476.0Region(Microbial infection) Interacts with HIV-1 capsid protein p24 (CA)
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-522236_14182841476.0Region29 X 2 AA repeats of F-G
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-5221000_10012841476.0Repeat9
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-5221024_10252841476.0Repeat10
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-5221084_10852841476.0Repeat11
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-5221118_11192841476.0Repeat12
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-5221135_11362841476.0Repeat13
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-5221173_11742841476.0Repeat14
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-5221212_12132841476.0Repeat15
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-5221228_12292841476.0Repeat16
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-5221240_12412841476.0Repeat17
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-5221275_12762841476.0Repeat18
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-5221289_12902841476.0Repeat19
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-5221291_12922841476.0Repeat20
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-5221306_13072841476.0Repeat21
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-5221319_13202841476.0Repeat22
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-5221327_13282841476.0Repeat23
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-5221341_13422841476.0Repeat24
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-5221362_13632841476.0Repeat25
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-5221374_13752841476.0Repeat26
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-5221383_13842841476.0Repeat27
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-5221397_13982841476.0Repeat28
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-5221417_14182841476.0Repeat29
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-522652_6532841476.0Repeat2
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-522715_7162841476.0Repeat3
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-522786_7872841476.0Repeat4
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-522905_9062841476.0Repeat5
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-522926_9272841476.0Repeat6
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-522961_9622841476.0Repeat7
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-522983_9842841476.0Repeat8
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-522657_6872841476.0Zinc fingerRanBP2-type 1
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-522722_7512841476.0Zinc fingerRanBP2-type 2
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-522793_8222841476.0Zinc fingerRanBP2-type 3
HgeneNUP153chr6:17675136chr6:10819173ENST00000262077-522851_8802841476.0Zinc fingerRanBP2-type 4
TgeneMAKchr6:17675136chr6:10819173ENST000003132431144_28433624.0DomainProtein kinase
TgeneMAKchr6:17675136chr6:10819173ENST000003544890134_28433624.0DomainProtein kinase
TgeneMAKchr6:17675136chr6:10819173ENST000004740391144_28433624.0DomainProtein kinase
TgeneMAKchr6:17675136chr6:10819173ENST0000031324311410_1833624.0Nucleotide bindingATP
TgeneMAKchr6:17675136chr6:10819173ENST0000035448901310_1833624.0Nucleotide bindingATP
TgeneMAKchr6:17675136chr6:10819173ENST0000047403911410_1833624.0Nucleotide bindingATP


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Fusion Gene Sequence for NUP153-MAK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>60975_60975_1_NUP153-MAK_NUP153_chr6_17675136_ENST00000262077_MAK_chr6_10819173_ENST00000536370_length(transcript)=2293nt_BP=852nt
ATGGCCTCGGGAGCCGGAGGAGTCGGAGGGGGCGGTGGCGGCAAGATCCGGACGCGGCGTTGCCACCAGGGGCCAATTAAGCCTTACCAG
CAGGGGCGACAACAGCATCAGGGCATTCTTAGCAGGGTTACAGAATCTGTTAAGAATATTGTGCCAGGGTGGCTACAAAGATACTTCAAC
AAGAATGAAGATGTATGCAGCTGTTCAACAGACACAAGCGAGGTTCCACGCTGGCCAGAAAATAAAGAGGACCATCTGGTATATGCCGAT
GAGGAGAGCTCTAATATTACTGATGGGAGAATCACACCTGAGCCAGCAGTCAGTAATACAGAAGAACCTTCAACAACTAGTACTGCTTCA
AATTATCCAGATGTGTTAACAAGGCCTTCTCTTCATCGGAGCCATCTGAATTTTTCCATGTTGGAATCCCCTGCATTACACTGTCAGCCA
TCTACATCCTCGGCATTCCCAATTGGCAGTTCGGGATTTTCCCTTGTAAAGGAAATTAAAGATTCTACCTCTCAGCATGATGATGATAAC
ATCTCAACTACCAGTGGTTTTTCTTCAAGAGCTTCTGATAAAGATATAACTGTTTCAAAGAACACTTCATTGCCACCTCTGTGGTCCCCA
GAAGCTGAACGTTCTCACTCACTCTCACAGCACACTGCCACCAGCTCAAAAAAACCAGCATTCAACTTGTCTGCCTTTGGAACACTTTCC
CCTTCACTTGGGAATTCTTCAATCCTTAAAACCAGTCAGCTTGGAGATTCTCCTTTTTATCCTGGAAAAACAACATACGGTGGGGCAGCA
GCTGCTGTAAGACAGTCTAAACTACGAAATACACCTTATCAGGATGAAGAGAAAGTTCTATTCTTGGGATGAATGCATGAACTTGAGAGA
AGTTAAGTCTCTGAAGAAACTTAATCATGCCAATGTTATTAAATTGAAAGAAGTTATCAGAGAAAATGACCATCTTTATTTTATATTTGA
ATATATGAAAGAAAACCTCTATCAATTAATGAAAGACAGAAACAAGTTGTTCCCTGAATCAGTCATCAGAAATATTATGTATCAAATATT
GCAAGGGCTGGCTTTTATCCATAAACATGGCTTTTTTCATAGGGACATGAAACCAGAAAACTTGCTTTGTATGGGTCCAGAGCTTGTGAA
AATTGCTGATTTTGGACTTGCAAGAGAATTAAGGTCACAGCCACCATACACTGATTATGTATCTACCAGATGGTATCGTGCCCCTGAAGT
TTTACTGAGATCTTCAGTTTATAGTTCTCCCATTGATGTGTGGGCTGTTGGAAGTATCATGGCTGAACTCTATATGTTAAGGCCACTTTT
CCCAGGGACAAGTGAGGTCGATGAAATCTTTAAAATTTGCCAAGTTTTAGGGACTCCCAAAAAAAGTGACTGGCCAGAAGGATACCAGCT
GGCATCCTCTATGAACTTCCGTTTTCCCCAGTGTGTTCCTATAAACTTAAAAACTCTTATTCCCAATGCCAGTAATGAAGCTATTCAGCT
CATGACCGAAATGTTGAATTGGGATCCAAAGAAACGACCGACAGCAAGCCAGCCCTGCTTTTTAGTGGAAGTGGAAAGACCTAATTAGGG
AGAGAGGTTGGTTAAGTTGTAGAATATGAAGACCATTTAAAGTACCAAGCTGCCTTCTGTTCCTCTAAAAACTGCCCTTACACATGGGAG
GAGTTAACTGTTGGTCAGGGCTATGTTCCCACCTATGTGGGGACTGGCTAAAGGCAGGAGGTTCAGGGGAACAGAGCTTGACCATCTTAA
GGAACCCATCCCCCCAAAAATGACCAGCTACTTTGCCCAGGCATTGAAACACCCATATTTTCAAGTTGGTCAGGTATTAGGCCCTTCGTC
AAATCATCTGGAATCAAAACAGTCTTTAAATAAGCAGCTGCAACCATTAGAATCAAAGCCATCTTTAGTTGAGGTAGAGCCTAAGCCTCT
GCCGGATATAATCGATCAGGTTGTTGGACAACCCCAGCCAAAAACTAGCCAGCAGCCACTGCAGCCCATTCAGCCGCCACAGAACCTGAG
CGTCCAGCAACCTCCAAAGCAACAGAGTCAGGAGAAACCGCCACAAACGCTATTCCCGAGCATCGTCAAAAACATGCCAACTAAGCCAAA
TGGCACACTGAGTCATAAAAGTGGTAGGAGGCGTTGGGGTCAGACTATCTTCAAGTCTGGAGATAGCTGGGAAGAGTTGGAGGACTATGA

>60975_60975_1_NUP153-MAK_NUP153_chr6_17675136_ENST00000262077_MAK_chr6_10819173_ENST00000536370_length(amino acids)=293AA_BP=
MASGAGGVGGGGGGKIRTRRCHQGPIKPYQQGRQQHQGILSRVTESVKNIVPGWLQRYFNKNEDVCSCSTDTSEVPRWPENKEDHLVYAD
EESSNITDGRITPEPAVSNTEEPSTTSTASNYPDVLTRPSLHRSHLNFSMLESPALHCQPSTSSAFPIGSSGFSLVKEIKDSTSQHDDDN
ISTTSGFSSRASDKDITVSKNTSLPPLWSPEAERSHSLSQHTATSSKKPAFNLSAFGTLSPSLGNSSILKTSQLGDSPFYPGKTTYGGAA

--------------------------------------------------------------
>60975_60975_2_NUP153-MAK_NUP153_chr6_17675136_ENST00000262077_MAK_chr6_10819173_ENST00000538030_length(transcript)=2979nt_BP=852nt
ATGGCCTCGGGAGCCGGAGGAGTCGGAGGGGGCGGTGGCGGCAAGATCCGGACGCGGCGTTGCCACCAGGGGCCAATTAAGCCTTACCAG
CAGGGGCGACAACAGCATCAGGGCATTCTTAGCAGGGTTACAGAATCTGTTAAGAATATTGTGCCAGGGTGGCTACAAAGATACTTCAAC
AAGAATGAAGATGTATGCAGCTGTTCAACAGACACAAGCGAGGTTCCACGCTGGCCAGAAAATAAAGAGGACCATCTGGTATATGCCGAT
GAGGAGAGCTCTAATATTACTGATGGGAGAATCACACCTGAGCCAGCAGTCAGTAATACAGAAGAACCTTCAACAACTAGTACTGCTTCA
AATTATCCAGATGTGTTAACAAGGCCTTCTCTTCATCGGAGCCATCTGAATTTTTCCATGTTGGAATCCCCTGCATTACACTGTCAGCCA
TCTACATCCTCGGCATTCCCAATTGGCAGTTCGGGATTTTCCCTTGTAAAGGAAATTAAAGATTCTACCTCTCAGCATGATGATGATAAC
ATCTCAACTACCAGTGGTTTTTCTTCAAGAGCTTCTGATAAAGATATAACTGTTTCAAAGAACACTTCATTGCCACCTCTGTGGTCCCCA
GAAGCTGAACGTTCTCACTCACTCTCACAGCACACTGCCACCAGCTCAAAAAAACCAGCATTCAACTTGTCTGCCTTTGGAACACTTTCC
CCTTCACTTGGGAATTCTTCAATCCTTAAAACCAGTCAGCTTGGAGATTCTCCTTTTTATCCTGGAAAAACAACATACGGTGGGGCAGCA
GCTGCTGTAAGACAGTCTAAACTACGAAATACACCTTATCAGGATGAAGAGAAAGTTCTATTCTTGGGATGAATGCATGAACTTGAGAGA
AGTTAAGTCTCTGAAGAAACTTAATCATGCCAATGTTATTAAATTGAAAGAAGTTATCAGAGAAAATGACCATCTTTATTTTATATTTGA
ATATATGAAAGAAAACCTCTATCAATTAATGAAAGACAGAAACAAGTTGTTCCCTGAATCAGTCATCAGAAATATTATGTATCAAATATT
GCAAGGGCTGGCTTTTATCCATAAACATGGCTTTTTTCATAGGGACATGAAACCAGAAAACTTGCTTTGTATGGGTCCAGAGCTTGTGAA
AATTGCTGATTTTGGACTTGCAAGAGAATTAAGGTCACAGCCACCATACACTGATTATGTATCTACCAGATGGTATCGTGCCCCTGAAGT
TTTACTGAGATCTTCAGTTTATAGTTCTCCCATTGATGTGTGGGCTGTTGGAAGTATCATGGCTGAACTCTATATGTTAAGGCCACTTTT
CCCAGGGACAAGTGAGGTCGATGAAATCTTTAAAATTTGCCAAGTTTTAGGGACTCCCAAAAAAAGTGACTGGCCAGAAGGATACCAGCT
GGCATCCTCTATGAACTTCCGTTTTCCCCAGTGTGTTCCTATAAACTTAAAAACTCTTATTCCCAATGCCAGTAATGAAGCTATTCAGCT
CATGACCGAAATGTTGAATTGGGATCCAAAGAAACGACCGACAGCAAGCCAGGCATTGAAACACCCATATTTTCAAGTTGGTCAGGTATT
AGGCCCTTCGTCAAATCATCTGGAATCAAAACAGTCTTTAAATAAGCAGCTGCAACCATTAGAATCAAAGCCATCTTTAGTTGAGGTAGA
GCCTAAGCCTCTGCCGGATATAATCGATCAGGTTGTTGGACAACCCCAGCCAAAAACTAGCCAGCAGCCACTGCAGCCCATTCAGCCGCC
ACAGAACCTGAGCGTCCAGCAACCTCCAAAGCAACAGAGTCAGGAGAAACCGCCACAAACGCTATTCCCGAGCATCGTCAAAAACATGCC
AACTAAGCCAAATGGCACACTGAGTCATAAAAGTGGTAGGAGGCGTTGGGGTCAGACTATCTTCAAGTCTGGAGATAGCTGGGAAGAGTT
GGAGGACTATGATTTCGGAGCCTCCCATTCCAAGAAGCCAAGCATGGGTGTTTTTAAAGAAAAAAGGAAAAAAGATTCTCCATTTCGTCA
ACAGGTGAAGATGGCTGTTATTTCCCTCTCAGCACACCAGTTTCCCACGTTATGAATCCAACTGCAGCCGTTGCAGGACAGATAGAAACA
TGTTACACACAAGCTTCCAGAGCCAGTACCCTCAGGCTCCAACCACTCGACAGGGGAAAACAAGAGCTTACCTGCTGTTACTTCCCTAAA
ATCTGATTCCGAATTGTCAACTGCTCCAACCTCTAAACAGTACTACTTGAAACAATCAAGATATCTTCCAGGTGTGAATCCCAAGAAGGT
GTCCTTGATAGCCAGTGGAAAGGAAATAAACCCCCACACTTGGAGCAACCAGTTATTCCCCAAGTCACTGGGACCCGTTGGGGCAGAACT
TGCTTTCAAAAGGAGCAATGCAGGAAATCTTGGAAGTTATGCTACTTACAATCAGTCAGGATATATTCCTTCCTTTCTCAAAAAAGAAGT
GCAGTCAGCTGGCCAGAGGATCCACTTAGCACCTCTCAATGCAACGGCTTCAGAATATACCTGGAACACAAAAACTGGTCGGGGGCAGTT
TTCAGGACGTACTTATAATCCTACAGCAAAAAACCTAAATATTGTGAACCGTGCACAGCCCATTCCCTCAGTGCATGGGAGGACAGACTG
GGTGGCCAAGTATGGAGGCCACCGGTAGGAGTCTATGGTGTGAAACCCTACAGCATTGCTCCGTAGAGTACGTGCAAGTTCCTTGACCCT
GGGAAATGTCTACAAATGTCTATTTCTACTGAGTTCTGGAAGAAATATGCAAAAGTGGGTACTTGGAAGGGCAAAAATCATCCCCTATTT
TACTTATTTCCAAGAAATGCATTTTCTTAGCATCATTGCCCACAGTGTTGATATATGGGTAGGATGTTACAAAGTATTGAATAAACTATT

>60975_60975_2_NUP153-MAK_NUP153_chr6_17675136_ENST00000262077_MAK_chr6_10819173_ENST00000538030_length(amino acids)=423AA_BP=0
MKRKFYSWDECMNLREVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHR
DMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQ
VLGTPKKSDWPEGYQLASSMNFRFPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSNHLESKQSLN
KQLQPLESKPSLVEVEPKPLPDIIDQVVGQPQPKTSQQPLQPIQPPQNLSVQQPPKQQSQEKPPQTLFPSIVKNMPTKPNGTLSHKSGRR

--------------------------------------------------------------
>60975_60975_3_NUP153-MAK_NUP153_chr6_17675136_ENST00000537253_MAK_chr6_10819173_ENST00000536370_length(transcript)=2331nt_BP=890nt
TTACCCGCCCCGGAGCGGGAAGCGGCGGAGGCTCCGCCATGGCCTCGGGAGCCGGAGGAGTCGGAGGGGGCGGTGGCGGCAAGATCCGGA
CGCGGCGTTGCCACCAGGGGCCAATTAAGCCTTACCAGCAGGGGCGACAACAGCATCAGGGCATTCTTAGCAGGGTTACAGAATCTGTTA
AGAATATTGTGCCAGGGTGGCTACAAAGATACTTCAACAAGAATGAAGATGTATGCAGCTGTTCAACAGACACAAGCGAGGTTCCACGCT
GGCCAGAAAATAAAGAGGACCATCTGGTATATGCCGATGAGGAGAGCTCTAATATTACTGATGGGAGAATCACACCTGAGCCAGCAGTCA
GTAATACAGAAGAACCTTCAACAACTAGTACTGCTTCAAATTATCCAGATGTGTTAACAAGGCCTTCTCTTCATCGGAGCCATCTGAATT
TTTCCATGTTGGAATCCCCTGCATTACACTGTCAGCCATCTACATCCTCGGCATTCCCAATTGGCAGTTCGGGATTTTCCCTTGTAAAGG
AAATTAAAGATTCTACCTCTCAGCATGATGATGATAACATCTCAACTACCAGTGGTTTTTCTTCAAGAGCTTCTGATAAAGATATAACTG
TTTCAAAGAACACTTCATTGCCACCTCTGTGGTCCCCAGAAGCTGAACGTTCTCACTCACTCTCACAGCACACTGCCACCAGCTCAAAAA
AACCAGCATTCAACTTGTCTGCCTTTGGAACACTTTCCCCTTCACTTGGGAATTCTTCAATCCTTAAAACCAGTCAGCTTGGAGATTCTC
CTTTTTATCCTGGAAAAACAACATACGGTGGGGCAGCAGCTGCTGTAAGACAGTCTAAACTACGAAATACACCTTATCAGGATGAAGAGA
AAGTTCTATTCTTGGGATGAATGCATGAACTTGAGAGAAGTTAAGTCTCTGAAGAAACTTAATCATGCCAATGTTATTAAATTGAAAGAA
GTTATCAGAGAAAATGACCATCTTTATTTTATATTTGAATATATGAAAGAAAACCTCTATCAATTAATGAAAGACAGAAACAAGTTGTTC
CCTGAATCAGTCATCAGAAATATTATGTATCAAATATTGCAAGGGCTGGCTTTTATCCATAAACATGGCTTTTTTCATAGGGACATGAAA
CCAGAAAACTTGCTTTGTATGGGTCCAGAGCTTGTGAAAATTGCTGATTTTGGACTTGCAAGAGAATTAAGGTCACAGCCACCATACACT
GATTATGTATCTACCAGATGGTATCGTGCCCCTGAAGTTTTACTGAGATCTTCAGTTTATAGTTCTCCCATTGATGTGTGGGCTGTTGGA
AGTATCATGGCTGAACTCTATATGTTAAGGCCACTTTTCCCAGGGACAAGTGAGGTCGATGAAATCTTTAAAATTTGCCAAGTTTTAGGG
ACTCCCAAAAAAAGTGACTGGCCAGAAGGATACCAGCTGGCATCCTCTATGAACTTCCGTTTTCCCCAGTGTGTTCCTATAAACTTAAAA
ACTCTTATTCCCAATGCCAGTAATGAAGCTATTCAGCTCATGACCGAAATGTTGAATTGGGATCCAAAGAAACGACCGACAGCAAGCCAG
CCCTGCTTTTTAGTGGAAGTGGAAAGACCTAATTAGGGAGAGAGGTTGGTTAAGTTGTAGAATATGAAGACCATTTAAAGTACCAAGCTG
CCTTCTGTTCCTCTAAAAACTGCCCTTACACATGGGAGGAGTTAACTGTTGGTCAGGGCTATGTTCCCACCTATGTGGGGACTGGCTAAA
GGCAGGAGGTTCAGGGGAACAGAGCTTGACCATCTTAAGGAACCCATCCCCCCAAAAATGACCAGCTACTTTGCCCAGGCATTGAAACAC
CCATATTTTCAAGTTGGTCAGGTATTAGGCCCTTCGTCAAATCATCTGGAATCAAAACAGTCTTTAAATAAGCAGCTGCAACCATTAGAA
TCAAAGCCATCTTTAGTTGAGGTAGAGCCTAAGCCTCTGCCGGATATAATCGATCAGGTTGTTGGACAACCCCAGCCAAAAACTAGCCAG
CAGCCACTGCAGCCCATTCAGCCGCCACAGAACCTGAGCGTCCAGCAACCTCCAAAGCAACAGAGTCAGGAGAAACCGCCACAAACGCTA
TTCCCGAGCATCGTCAAAAACATGCCAACTAAGCCAAATGGCACACTGAGTCATAAAAGTGGTAGGAGGCGTTGGGGTCAGACTATCTTC

>60975_60975_3_NUP153-MAK_NUP153_chr6_17675136_ENST00000537253_MAK_chr6_10819173_ENST00000536370_length(amino acids)=293AA_BP=
MASGAGGVGGGGGGKIRTRRCHQGPIKPYQQGRQQHQGILSRVTESVKNIVPGWLQRYFNKNEDVCSCSTDTSEVPRWPENKEDHLVYAD
EESSNITDGRITPEPAVSNTEEPSTTSTASNYPDVLTRPSLHRSHLNFSMLESPALHCQPSTSSAFPIGSSGFSLVKEIKDSTSQHDDDN
ISTTSGFSSRASDKDITVSKNTSLPPLWSPEAERSHSLSQHTATSSKKPAFNLSAFGTLSPSLGNSSILKTSQLGDSPFYPGKTTYGGAA

--------------------------------------------------------------
>60975_60975_4_NUP153-MAK_NUP153_chr6_17675136_ENST00000537253_MAK_chr6_10819173_ENST00000538030_length(transcript)=3017nt_BP=890nt
TTACCCGCCCCGGAGCGGGAAGCGGCGGAGGCTCCGCCATGGCCTCGGGAGCCGGAGGAGTCGGAGGGGGCGGTGGCGGCAAGATCCGGA
CGCGGCGTTGCCACCAGGGGCCAATTAAGCCTTACCAGCAGGGGCGACAACAGCATCAGGGCATTCTTAGCAGGGTTACAGAATCTGTTA
AGAATATTGTGCCAGGGTGGCTACAAAGATACTTCAACAAGAATGAAGATGTATGCAGCTGTTCAACAGACACAAGCGAGGTTCCACGCT
GGCCAGAAAATAAAGAGGACCATCTGGTATATGCCGATGAGGAGAGCTCTAATATTACTGATGGGAGAATCACACCTGAGCCAGCAGTCA
GTAATACAGAAGAACCTTCAACAACTAGTACTGCTTCAAATTATCCAGATGTGTTAACAAGGCCTTCTCTTCATCGGAGCCATCTGAATT
TTTCCATGTTGGAATCCCCTGCATTACACTGTCAGCCATCTACATCCTCGGCATTCCCAATTGGCAGTTCGGGATTTTCCCTTGTAAAGG
AAATTAAAGATTCTACCTCTCAGCATGATGATGATAACATCTCAACTACCAGTGGTTTTTCTTCAAGAGCTTCTGATAAAGATATAACTG
TTTCAAAGAACACTTCATTGCCACCTCTGTGGTCCCCAGAAGCTGAACGTTCTCACTCACTCTCACAGCACACTGCCACCAGCTCAAAAA
AACCAGCATTCAACTTGTCTGCCTTTGGAACACTTTCCCCTTCACTTGGGAATTCTTCAATCCTTAAAACCAGTCAGCTTGGAGATTCTC
CTTTTTATCCTGGAAAAACAACATACGGTGGGGCAGCAGCTGCTGTAAGACAGTCTAAACTACGAAATACACCTTATCAGGATGAAGAGA
AAGTTCTATTCTTGGGATGAATGCATGAACTTGAGAGAAGTTAAGTCTCTGAAGAAACTTAATCATGCCAATGTTATTAAATTGAAAGAA
GTTATCAGAGAAAATGACCATCTTTATTTTATATTTGAATATATGAAAGAAAACCTCTATCAATTAATGAAAGACAGAAACAAGTTGTTC
CCTGAATCAGTCATCAGAAATATTATGTATCAAATATTGCAAGGGCTGGCTTTTATCCATAAACATGGCTTTTTTCATAGGGACATGAAA
CCAGAAAACTTGCTTTGTATGGGTCCAGAGCTTGTGAAAATTGCTGATTTTGGACTTGCAAGAGAATTAAGGTCACAGCCACCATACACT
GATTATGTATCTACCAGATGGTATCGTGCCCCTGAAGTTTTACTGAGATCTTCAGTTTATAGTTCTCCCATTGATGTGTGGGCTGTTGGA
AGTATCATGGCTGAACTCTATATGTTAAGGCCACTTTTCCCAGGGACAAGTGAGGTCGATGAAATCTTTAAAATTTGCCAAGTTTTAGGG
ACTCCCAAAAAAAGTGACTGGCCAGAAGGATACCAGCTGGCATCCTCTATGAACTTCCGTTTTCCCCAGTGTGTTCCTATAAACTTAAAA
ACTCTTATTCCCAATGCCAGTAATGAAGCTATTCAGCTCATGACCGAAATGTTGAATTGGGATCCAAAGAAACGACCGACAGCAAGCCAG
GCATTGAAACACCCATATTTTCAAGTTGGTCAGGTATTAGGCCCTTCGTCAAATCATCTGGAATCAAAACAGTCTTTAAATAAGCAGCTG
CAACCATTAGAATCAAAGCCATCTTTAGTTGAGGTAGAGCCTAAGCCTCTGCCGGATATAATCGATCAGGTTGTTGGACAACCCCAGCCA
AAAACTAGCCAGCAGCCACTGCAGCCCATTCAGCCGCCACAGAACCTGAGCGTCCAGCAACCTCCAAAGCAACAGAGTCAGGAGAAACCG
CCACAAACGCTATTCCCGAGCATCGTCAAAAACATGCCAACTAAGCCAAATGGCACACTGAGTCATAAAAGTGGTAGGAGGCGTTGGGGT
CAGACTATCTTCAAGTCTGGAGATAGCTGGGAAGAGTTGGAGGACTATGATTTCGGAGCCTCCCATTCCAAGAAGCCAAGCATGGGTGTT
TTTAAAGAAAAAAGGAAAAAAGATTCTCCATTTCGTCAACAGGTGAAGATGGCTGTTATTTCCCTCTCAGCACACCAGTTTCCCACGTTA
TGAATCCAACTGCAGCCGTTGCAGGACAGATAGAAACATGTTACACACAAGCTTCCAGAGCCAGTACCCTCAGGCTCCAACCACTCGACA
GGGGAAAACAAGAGCTTACCTGCTGTTACTTCCCTAAAATCTGATTCCGAATTGTCAACTGCTCCAACCTCTAAACAGTACTACTTGAAA
CAATCAAGATATCTTCCAGGTGTGAATCCCAAGAAGGTGTCCTTGATAGCCAGTGGAAAGGAAATAAACCCCCACACTTGGAGCAACCAG
TTATTCCCCAAGTCACTGGGACCCGTTGGGGCAGAACTTGCTTTCAAAAGGAGCAATGCAGGAAATCTTGGAAGTTATGCTACTTACAAT
CAGTCAGGATATATTCCTTCCTTTCTCAAAAAAGAAGTGCAGTCAGCTGGCCAGAGGATCCACTTAGCACCTCTCAATGCAACGGCTTCA
GAATATACCTGGAACACAAAAACTGGTCGGGGGCAGTTTTCAGGACGTACTTATAATCCTACAGCAAAAAACCTAAATATTGTGAACCGT
GCACAGCCCATTCCCTCAGTGCATGGGAGGACAGACTGGGTGGCCAAGTATGGAGGCCACCGGTAGGAGTCTATGGTGTGAAACCCTACA
GCATTGCTCCGTAGAGTACGTGCAAGTTCCTTGACCCTGGGAAATGTCTACAAATGTCTATTTCTACTGAGTTCTGGAAGAAATATGCAA
AAGTGGGTACTTGGAAGGGCAAAAATCATCCCCTATTTTACTTATTTCCAAGAAATGCATTTTCTTAGCATCATTGCCCACAGTGTTGAT

>60975_60975_4_NUP153-MAK_NUP153_chr6_17675136_ENST00000537253_MAK_chr6_10819173_ENST00000538030_length(amino acids)=423AA_BP=0
MKRKFYSWDECMNLREVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHR
DMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQ
VLGTPKKSDWPEGYQLASSMNFRFPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSNHLESKQSLN
KQLQPLESKPSLVEVEPKPLPDIIDQVVGQPQPKTSQQPLQPIQPPQNLSVQQPPKQQSQEKPPQTLFPSIVKNMPTKPNGTLSHKSGRR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NUP153-MAK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NUP153-MAK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NUP153-MAK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource