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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NUP155-ZFYVE26 (FusionGDB2 ID:60991)

Fusion Gene Summary for NUP155-ZFYVE26

Fusion gene summary

Fusion gene information	Fusion gene name: NUP155-ZFYVE26
	Fusion gene ID: 60991
		Hgene	Tgene
	Gene symbol	NUP155	ZFYVE26
	Gene ID	9631	23503
	Gene name	nucleoporin 155	zinc finger FYVE-type containing 26
	Synonyms	ATFB15\|N155	FYVE-CENT\|SPG15
	Cytomap	5p13.2	14q24.1
	Type of gene	protein-coding	protein-coding
	Description	nuclear pore complex protein Nup155155 kDa nucleoporinnucleoporin 155kDnucleoporin 155kDa	zinc finger FYVE domain-containing protein 26FYVE domain-containing centrosomal proteinspastizinzinc finger, FYVE domain containing 26
	Modification date	20200329	20200320
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000231498, ENST00000513532, ENST00000381843, ENST00000502533,	ENST00000555452, ENST00000557306, ENST00000347230,
Fusion gene scores	* DoF score	8 X 8 X 6=384	9 X 8 X 4=288
	# samples	8	10
	** MAII score	log2(8/384*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/288*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NUP155 [Title/Abstract] AND ZFYVE26 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NUP155(37370923)-ZFYVE26(68244965), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NUP155	GO:0006998	nuclear envelope organization	19070573

Fusion gene breakpoints across NUP155 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ZFYVE26 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-E2-A15K-01A	NUP155	chr5	37370923	-	ZFYVE26	chr14	68244965	-

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Fusion Gene ORF analysis for NUP155-ZFYVE26

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000231498	ENST00000555452	NUP155	chr5	37370923	-	ZFYVE26	chr14	68244965	-
5CDS-intron	ENST00000231498	ENST00000557306	NUP155	chr5	37370923	-	ZFYVE26	chr14	68244965	-
5CDS-intron	ENST00000513532	ENST00000555452	NUP155	chr5	37370923	-	ZFYVE26	chr14	68244965	-
5CDS-intron	ENST00000513532	ENST00000557306	NUP155	chr5	37370923	-	ZFYVE26	chr14	68244965	-
In-frame	ENST00000231498	ENST00000347230	NUP155	chr5	37370923	-	ZFYVE26	chr14	68244965	-
In-frame	ENST00000513532	ENST00000347230	NUP155	chr5	37370923	-	ZFYVE26	chr14	68244965	-
intron-3CDS	ENST00000381843	ENST00000347230	NUP155	chr5	37370923	-	ZFYVE26	chr14	68244965	-
intron-3CDS	ENST00000502533	ENST00000347230	NUP155	chr5	37370923	-	ZFYVE26	chr14	68244965	-
intron-intron	ENST00000381843	ENST00000555452	NUP155	chr5	37370923	-	ZFYVE26	chr14	68244965	-
intron-intron	ENST00000381843	ENST00000557306	NUP155	chr5	37370923	-	ZFYVE26	chr14	68244965	-
intron-intron	ENST00000502533	ENST00000555452	NUP155	chr5	37370923	-	ZFYVE26	chr14	68244965	-
intron-intron	ENST00000502533	ENST00000557306	NUP155	chr5	37370923	-	ZFYVE26	chr14	68244965	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000231498	NUP155	chr5	37370923	-	ENST00000347230	ZFYVE26	chr14	68244965	-	5223	361	166	3306	1046
ENST00000513532	NUP155	chr5	37370923	-	ENST00000347230	ZFYVE26	chr14	68244965	-	5123	261	66	3206	1046

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000231498	ENST00000347230	NUP155	chr5	37370923	-	ZFYVE26	chr14	68244965	-	0.001732894	0.99826705
ENST00000513532	ENST00000347230	NUP155	chr5	37370923	-	ZFYVE26	chr14	68244965	-	0.001584314	0.9984157

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Fusion Genomic Features for NUP155-ZFYVE26

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NUP155-ZFYVE26

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:37370923/chr14:68244965)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ZFYVE26

chr5:37370923

chr14:68244965

ENST00000347230

1812_1872

1558

2540.0

Zinc finger

FYVE-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NUP155

chr5:37370923

chr14:68244965

ENST00000231498

585_655

1392.0

Compositional bias

Note=Pro-rich

Hgene

NUP155

chr5:37370923

chr14:68244965

ENST00000381843

585_655

1333.0

Compositional bias

Note=Pro-rich

Tgene

ZFYVE26

chr5:37370923

chr14:68244965

ENST00000347230

868_895

1558

2540.0

Coiled coil

Ontology_term=ECO:0000255

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Fusion Gene Sequence for NUP155-ZFYVE26

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>60991_60991_1_NUP155-ZFYVE26_NUP155_chr5_37370923_ENST00000231498_ZFYVE26_chr14_68244965_ENST00000347230_length(transcript)=5223nt_BP=361nt
CTCCCAACAGCTTCCTCTTCCCAGGCCAGAACGGCGTCTTCCAGTTCCCCACCGGATGAAGCGGAAGTGCGTCATGTCGAGGCGCCAAGG
CGCTCGTTTGGCGCGCGCGCCCTAGGCGGCGGATCTAAGCTAACTTCTTGGATCTTTTCTTGTTTCTCCTTGGTTTTTGACTTTTTCTGG
ACCCTGGTGTCTACGATTTCCGAGATGCCGTCTTCTTTGTTGGGCGCGGCGATGCCGGCCTCTACATCTGCCGCAGCCCTGCAGGAAGCT
CTGGAAAATGCTGGACGGCTCATCGACCGTCAGTTGCAAGAGGACCGCATGTACCCGGACCTTTCCGAGCTGCTTATGGTGTCTGCCCCA
AGAGTATGAACTGTGTGAAGAGTGGGGCTGCCTGTACCCCATTCCAAGAGAACATTTAATCAGCCTTCATCAAAAGCATCTTCTCCACCT
TCTAGAAAGAAGAGATCATGACAAGGCTCTGCAACTCCTGCGAAGAATCCCTGACCCCACCATGTGCCTTGAAGTGACAGAGCAATCCCT
CGACCAGCACACTAGCTTGGCCACTTCTCACTTCTTGGCCAACTACCTCACCACCCACTTCTATGGACAACTGACTGCTGTCCGACACCG
TGAAATCCAGGCGCTGTATGTGGGATCCAAGATTCTGCTGACCCTGCCTGAGCAGCACCGGGCCAGCTATTCCCACTTGTCCTCTAACCC
CCTGTTCATGCTGGAGCAGCTGCTTATGAACATGAAGGTGGATTGGGCCACTGTGGCTGTGCAGACTCTCCAGCAGCTGCTGGTTGGACA
GGAGATTGGCTTCACTATGGACGAGGTGGACTCACTGCTTTCCAGATACGCAGAGAAAGCCCTGGACTTTCCATACCCTCAGAGGGAGAA
ACGATCAGATTCTGTGATTCACCTCCAAGAAATTGTCCACCAGGCTGCAGATCCCGAGACCCTCCCTAGATCACCATCAGCAGAGTTCTC
TCCTGCTGCTCCTCCTGGTATCTCCAGTATACATTCCCCTAGTCTAAGGGAAAGGAGTTTCCCACCAACCCAGCCCTCACAGGAATTTGT
GCCCCCAGCGACACCCCCTGCCAGGCACCAGTGGGTACCGGATGAGACTGAGAGTATCTGCATGGTCTGCTGCAGGGAGCACTTCACCAT
GTTTAACAGGCGTCATCATTGTCGCCGCTGTGGCCGGCTAGTGTGCAGCTCCTGCTCCACTAAGAAAATGGTGGTTGAAGGCTGCAGAGA
GAACCCTGCTCGTGTGTGTGATCAGTGCTATAGTTACTGCAACAAAGATGTACCAGAGGAGCCTTCAGAAAAACCAGAAGCTCTAGACAG
CTCCAAGAATGAAAGCCCTCCATACTCGTTTGTGGTGAGAGTCCCCAAAGCAGATGAGGTGGAATGGATTTTGGATCTCAAAGAGGAGGA
AAATGAGCTGGTGCGGAGTGAATTTTACTATGAGCAGGCCCCCAGCGCCTCCTTGTGCATTGCCATCCTGAATCTGCACCGGGACAGCAT
TGCCTGTGGTCACCAGCTGATTGAGCACTGCTGCAGGCTCTCCAAGGGCCTCACCAACCCAGAGGTGGATGCCGGGCTGCTCACGGACAT
CATGAAGCAGCTGCTGTTCAGCGCCAAGATGATGTTCGTCAAAGCCGGCCAGAGCCAAGACTTGGCTCTTTGTGACAGCTACATCAGCAA
GGTAGATGTGCTGAATATTTTAGTTGCTGCTGCCTATCGCCACGTGCCATCTTTGGATCAGATCTTGCAGCCAGCTGCAGTAACCAGGCT
AAGGAACCAGCTTTTGGAAGCCGAGTACTACCAACTGGGCGTTGAGGTCTCCACAAAGACTGGGCTTGATACCACCGGGGCGTGGCATGC
TTGGGGCATGGCCTGCCTCAAAGCCGGGAACCTCACTGCTGCACGGGAGAAGTTCAGTCGCTGTCTGAAGCCCCCATTTGACCTCAATCA
GCTGAATCATGGCTCAAGGCTGGTGCAGGATGTGGTTGAGTACCTAGAGTCCACAGTGAGGCCCTTTGTATCCTTGCAAGATGACGATTA
CTTTGCCACCCTGAGGGAACTGGAAGCTACCCTTCGGACGCAGAGCCTTTCTCTGGCAGTGATTCCTGAAGGGAAAATCATGAACAACAC
CTACTACCAGGAATGCCTCTTCTACCTGCACAACTATAGCACCAACCTGGCCATCATCAGCTTCTACGTGAGGCACAGCTGCCTGCGGGA
AGCTCTTCTGCACCTTCTCAACAAGGAGAGTCCTCCAGAAGTTTTTATAGAAGGCATTTTCCAACCAAGCTATAAAAGTGGGAAGCTACA
CACTTTGGAGAACTTGCTAGAATCCATTGATCCAACCTTGGAGAGCTGGGGAAAGTACTTGATTGCTGCCTGCCAACATTTACAGAAGAA
GAACTACTACCACATTCTGTATGAGCTGCAGCAGTTTATGAAGGACCAAGTTCGGGCCGCCATGACCTGTATTCGGTTCTTCAGTCACAA
AGCAAAGTCATATACAGAACTGGGAGAGAAGCTCTCATGGCTACTTAAGGCCAAGGACCACCTGAAGATCTACCTCCAAGAAACATCCCG
CAGCTCTGGAAGGAAGAAAACCACATTCTTCAGAAAGAAGATGACTGCAGCTGATGTGTCAAGGCACATGAACACACTTCAGCTGCAGAT
GGAAGTGACCAGGTTCTTGCATCGGTGCGAAAGTGCTGGGACCTCTCAAATCACCACTTTGCCTCTGCCAACCCTGTTTGGAAATAACCA
CATGAAAATGGATGTTGCCTGCAAGGTCATGCTGGGAGGGAAAAATGTAGAAGATGGTTTTGGAATTGCTTTCCGTGTTCTGCAGGACTT
CCAGCTGGATGCTGCCATGACCTACTGCAGAGCTGCCCGCCAGTTGGTGGAGAAAGAGAAGTACAGTGAGATCCAGCAACTGCTCAAATG
TGTCAGTGAGTCAGGCATGGCAGCCAAAAGTGACGGGGACACCATCCTCCTCAACTGCCTGGAAGCGTTCAAGAGAATTCCGCCCCAGGA
GCTGGAGGGCCTGATCCAGGCAATACACAATGATGACAACAAGGTTCGGGCCTACCTGATATGTTGCAAACTGCGTTCTGCCTACTTGAT
TGCTGTGAAGCAAGAACACTCACGGGCCACAGCCCTTGTCCAGCAGGTGCAGCAGGCCGCCAAGAGCAGCGGGGATGCAGTAGTGCAAGA
CATCTGTGCCCAGTGGCTTCTGACAAGCCACCCCCGGGGTGCCCATGGCCCAGGCTCCAGGAAGTGACCTTGGGCAGTGGGGCCAGGAAC
ACGTGGCCTGAGAGCTGGGCAACAGCAGTGATGGCGATGCCCTCCACCTCTTTCCTCCAGTGGAGTGGGACTTCTCTGGCTCTGCCCTAG
GTTGGAAAGAGTTGGATTGGACCCTACTTGCCTTCCCGGGCAAGGATAGGACCTTTCACGCAAGTGCCATGTTTCTCTAAAATTGTGGAA
TCTATGTGTGTTTGTCTGGAGATGGCCAGTTCTTTCTACCTCAGAGTGAGTGAGTGAGTATGTGTGCACACACGTGTGCATGTTCCTGTG
CGCTGATGTTTACGCCCAAGCATTTCTGAACAAATGAAACTCTTCTCCATTTAAAAGAGGCACTTTACTTTAGACTTGCCACTCTGAAAA
CCTTCCCTGCGTTTTGGTTCTTGACCCGGGTTGTCCTGTTTGTATAGTCCCCCCTCTGTGGACGTGCTTTAGTAGCTCCTCTTACCTAGA
GGGCTTTTACAGAGAATTAGAGCAACACCAAAAGGATTGCCTCTTTTCCTTCCTTCCCATTCCAAAATTCAGAGATGGCTTTGGGGCAAG
TGCTACCTGTGGAATAAACCTGTTTTCCAGGTGTCTCTTCTCCCAAGCACAAGAAGTCCTGGAGTCTTTGGAAGGTAGTCTGAATAGAAG
GGTTTTCAGGTGCAGGCATCTGAAAGCTGTGGGTATGTGTATAAATGATCAGGTCTGTGAGGCTAACACGGGCAAGAGGGAAAGAAAGGC
TAACCATCCAAACAGGGATACAGGGGAGGCGGTGGGGGGTGGTGGGGGGAGCGGGTGCTCACAAGCACAGAGCTGCCTGTTGTGAATGTC
CCTGCTGCAAAGTTGGTGGGTGAGAGAATGGGACTTCCTCTTTGAGAGTCTGGGGAGAGAAAAGGTGGCCAGGATCCTAGGACTGAATGA
CTCGATTTTACCTATTTGAGCTGCAGTCCTGTTTGCGCTCCTTGAATTGGTTAGGAAGCTGCTTCCTTTTCCCTCCTGCTTCCCTTCAGT
CTCTTCAGGACCACAGGATGGATATGCAGACATGTGGGGTCATTGGGAAGGGAGTGCGCTTCTTTTCTCTGTCTTAGAAAAGGGAGTCAA
GGGTTGGCTTTGGAATTGGGCCTCTGGACAGAGTCAGAATGAGGGAATAATGAATAGGTCACATCTGGTTGGTGGAAAACTAGGTGAAGT
GCTTCTTTAATATGCACTGTCTTGTCTTCCCACGCAAGATGTGACAATGTTTGAGAAAAGGTGTGTCATACTCAGTGACTTCAATTTGCA
AATGTGGGGCCTAAAGAAAGCTCTGCAGCTCTGAACCTCTCACTGGCCAGAGCTCAGCCTATTGGTCCCATCCATGATGCTGAGACAAAC
AGAAACTGGAAGCTGAAGTCAGTGTCTCTGGTGCTCAGAAACCCTGTGGATTTCCCTCTGAACCAAGATTTTTAGTAGTAAAATAAACAA
CTCATGGACATCTGTCAGATGAGAAGTTTTGGTCCTGTTAGAGAGGAGAAAGACTGTAATGAAACTACTAGACCCATTTGGGCTAAAGTT
TGGCTTTTCCTTCCTTGAGTCATAGAACGTATCCATCTCCCAGGAAATGTCCTTCTCTGGCGTCTGCTTGCCCTTCTGAGTCTGCCTTTT
TTGCACTGAACATAAGCACTTTATACTAATGGGTCACAAATCTTGCAGCCCTTAATTTGGGATAAGACCAGATTTTCCTGACATTTTCCT
CTAACTCATTGAACTATCAAATTATAGGCAACCACTGACTAGACTGATATGAGATGAGGCTAAAAGCCTTTGAACACCACGCTGTAGTCT
CCAACAGAAAAACACCACCAAAACAGATACCCATGTTGAGGGGTTGAATGTTTTACTACAAACAAGCCACAATAAAGTGTCTATCAACAT

>60991_60991_1_NUP155-ZFYVE26_NUP155_chr5_37370923_ENST00000231498_ZFYVE26_chr14_68244965_ENST00000347230_length(amino acids)=1046AA_BP=64
MTFSGPWCLRFPRCRLLCWARRCRPLHLPQPCRKLWKMLDGSSTVSCKRTACTRTFPSCLWCLPQEYELCEEWGCLYPIPREHLISLHQK
HLLHLLERRDHDKALQLLRRIPDPTMCLEVTEQSLDQHTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSH
LSSNPLFMLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPYPQREKRSDSVIHLQEIVHQAADPETLPRSP
SAEFSPAAPPGISSIHSPSLRERSFPPTQPSQEFVPPATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCSTKKMVV
EGCRENPARVCDQCYSYCNKDVPEEPSEKPEALDSSKNESPPYSFVVRVPKADEVEWILDLKEEENELVRSEFYYEQAPSASLCIAILNL
HRDSIACGHQLIEHCCRLSKGLTNPEVDAGLLTDIMKQLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYRHVPSLDQILQPA
AVTRLRNQLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACLKAGNLTAAREKFSRCLKPPFDLNQLNHGSRLVQDVVEYLESTVRPFVSL
QDDDYFATLRELEATLRTQSLSLAVIPEGKIMNNTYYQECLFYLHNYSTNLAIISFYVRHSCLREALLHLLNKESPPEVFIEGIFQPSYK
SGKLHTLENLLESIDPTLESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRAAMTCIRFFSHKAKSYTELGEKLSWLLKAKDHLKIYL
QETSRSSGRKKTTFFRKKMTAADVSRHMNTLQLQMEVTRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDGFGIAFR
VLQDFQLDAAMTYCRAARQLVEKEKYSEIQQLLKCVSESGMAAKSDGDTILLNCLEAFKRIPPQELEGLIQAIHNDDNKVRAYLICCKLR

--------------------------------------------------------------
>60991_60991_2_NUP155-ZFYVE26_NUP155_chr5_37370923_ENST00000513532_ZFYVE26_chr14_68244965_ENST00000347230_length(transcript)=5123nt_BP=261nt
GCGCGCGCGCCCTAGGCGGCGGATCTAAGCTAACTTCTTGGATCTTTTCTTGTTTCTCCTTGGTTTTTGACTTTTTCTGGACCCTGGTGT
CTACGATTTCCGAGATGCCGTCTTCTTTGTTGGGCGCGGCGATGCCGGCCTCTACATCTGCCGCAGCCCTGCAGGAAGCTCTGGAAAATG
CTGGACGGCTCATCGACCGTCAGTTGCAAGAGGACCGCATGTACCCGGACCTTTCCGAGCTGCTTATGGTGTCTGCCCCAAGAGTATGAA
CTGTGTGAAGAGTGGGGCTGCCTGTACCCCATTCCAAGAGAACATTTAATCAGCCTTCATCAAAAGCATCTTCTCCACCTTCTAGAAAGA
AGAGATCATGACAAGGCTCTGCAACTCCTGCGAAGAATCCCTGACCCCACCATGTGCCTTGAAGTGACAGAGCAATCCCTCGACCAGCAC
ACTAGCTTGGCCACTTCTCACTTCTTGGCCAACTACCTCACCACCCACTTCTATGGACAACTGACTGCTGTCCGACACCGTGAAATCCAG
GCGCTGTATGTGGGATCCAAGATTCTGCTGACCCTGCCTGAGCAGCACCGGGCCAGCTATTCCCACTTGTCCTCTAACCCCCTGTTCATG
CTGGAGCAGCTGCTTATGAACATGAAGGTGGATTGGGCCACTGTGGCTGTGCAGACTCTCCAGCAGCTGCTGGTTGGACAGGAGATTGGC
TTCACTATGGACGAGGTGGACTCACTGCTTTCCAGATACGCAGAGAAAGCCCTGGACTTTCCATACCCTCAGAGGGAGAAACGATCAGAT
TCTGTGATTCACCTCCAAGAAATTGTCCACCAGGCTGCAGATCCCGAGACCCTCCCTAGATCACCATCAGCAGAGTTCTCTCCTGCTGCT
CCTCCTGGTATCTCCAGTATACATTCCCCTAGTCTAAGGGAAAGGAGTTTCCCACCAACCCAGCCCTCACAGGAATTTGTGCCCCCAGCG
ACACCCCCTGCCAGGCACCAGTGGGTACCGGATGAGACTGAGAGTATCTGCATGGTCTGCTGCAGGGAGCACTTCACCATGTTTAACAGG
CGTCATCATTGTCGCCGCTGTGGCCGGCTAGTGTGCAGCTCCTGCTCCACTAAGAAAATGGTGGTTGAAGGCTGCAGAGAGAACCCTGCT
CGTGTGTGTGATCAGTGCTATAGTTACTGCAACAAAGATGTACCAGAGGAGCCTTCAGAAAAACCAGAAGCTCTAGACAGCTCCAAGAAT
GAAAGCCCTCCATACTCGTTTGTGGTGAGAGTCCCCAAAGCAGATGAGGTGGAATGGATTTTGGATCTCAAAGAGGAGGAAAATGAGCTG
GTGCGGAGTGAATTTTACTATGAGCAGGCCCCCAGCGCCTCCTTGTGCATTGCCATCCTGAATCTGCACCGGGACAGCATTGCCTGTGGT
CACCAGCTGATTGAGCACTGCTGCAGGCTCTCCAAGGGCCTCACCAACCCAGAGGTGGATGCCGGGCTGCTCACGGACATCATGAAGCAG
CTGCTGTTCAGCGCCAAGATGATGTTCGTCAAAGCCGGCCAGAGCCAAGACTTGGCTCTTTGTGACAGCTACATCAGCAAGGTAGATGTG
CTGAATATTTTAGTTGCTGCTGCCTATCGCCACGTGCCATCTTTGGATCAGATCTTGCAGCCAGCTGCAGTAACCAGGCTAAGGAACCAG
CTTTTGGAAGCCGAGTACTACCAACTGGGCGTTGAGGTCTCCACAAAGACTGGGCTTGATACCACCGGGGCGTGGCATGCTTGGGGCATG
GCCTGCCTCAAAGCCGGGAACCTCACTGCTGCACGGGAGAAGTTCAGTCGCTGTCTGAAGCCCCCATTTGACCTCAATCAGCTGAATCAT
GGCTCAAGGCTGGTGCAGGATGTGGTTGAGTACCTAGAGTCCACAGTGAGGCCCTTTGTATCCTTGCAAGATGACGATTACTTTGCCACC
CTGAGGGAACTGGAAGCTACCCTTCGGACGCAGAGCCTTTCTCTGGCAGTGATTCCTGAAGGGAAAATCATGAACAACACCTACTACCAG
GAATGCCTCTTCTACCTGCACAACTATAGCACCAACCTGGCCATCATCAGCTTCTACGTGAGGCACAGCTGCCTGCGGGAAGCTCTTCTG
CACCTTCTCAACAAGGAGAGTCCTCCAGAAGTTTTTATAGAAGGCATTTTCCAACCAAGCTATAAAAGTGGGAAGCTACACACTTTGGAG
AACTTGCTAGAATCCATTGATCCAACCTTGGAGAGCTGGGGAAAGTACTTGATTGCTGCCTGCCAACATTTACAGAAGAAGAACTACTAC
CACATTCTGTATGAGCTGCAGCAGTTTATGAAGGACCAAGTTCGGGCCGCCATGACCTGTATTCGGTTCTTCAGTCACAAAGCAAAGTCA
TATACAGAACTGGGAGAGAAGCTCTCATGGCTACTTAAGGCCAAGGACCACCTGAAGATCTACCTCCAAGAAACATCCCGCAGCTCTGGA
AGGAAGAAAACCACATTCTTCAGAAAGAAGATGACTGCAGCTGATGTGTCAAGGCACATGAACACACTTCAGCTGCAGATGGAAGTGACC
AGGTTCTTGCATCGGTGCGAAAGTGCTGGGACCTCTCAAATCACCACTTTGCCTCTGCCAACCCTGTTTGGAAATAACCACATGAAAATG
GATGTTGCCTGCAAGGTCATGCTGGGAGGGAAAAATGTAGAAGATGGTTTTGGAATTGCTTTCCGTGTTCTGCAGGACTTCCAGCTGGAT
GCTGCCATGACCTACTGCAGAGCTGCCCGCCAGTTGGTGGAGAAAGAGAAGTACAGTGAGATCCAGCAACTGCTCAAATGTGTCAGTGAG
TCAGGCATGGCAGCCAAAAGTGACGGGGACACCATCCTCCTCAACTGCCTGGAAGCGTTCAAGAGAATTCCGCCCCAGGAGCTGGAGGGC
CTGATCCAGGCAATACACAATGATGACAACAAGGTTCGGGCCTACCTGATATGTTGCAAACTGCGTTCTGCCTACTTGATTGCTGTGAAG
CAAGAACACTCACGGGCCACAGCCCTTGTCCAGCAGGTGCAGCAGGCCGCCAAGAGCAGCGGGGATGCAGTAGTGCAAGACATCTGTGCC
CAGTGGCTTCTGACAAGCCACCCCCGGGGTGCCCATGGCCCAGGCTCCAGGAAGTGACCTTGGGCAGTGGGGCCAGGAACACGTGGCCTG
AGAGCTGGGCAACAGCAGTGATGGCGATGCCCTCCACCTCTTTCCTCCAGTGGAGTGGGACTTCTCTGGCTCTGCCCTAGGTTGGAAAGA
GTTGGATTGGACCCTACTTGCCTTCCCGGGCAAGGATAGGACCTTTCACGCAAGTGCCATGTTTCTCTAAAATTGTGGAATCTATGTGTG
TTTGTCTGGAGATGGCCAGTTCTTTCTACCTCAGAGTGAGTGAGTGAGTATGTGTGCACACACGTGTGCATGTTCCTGTGCGCTGATGTT
TACGCCCAAGCATTTCTGAACAAATGAAACTCTTCTCCATTTAAAAGAGGCACTTTACTTTAGACTTGCCACTCTGAAAACCTTCCCTGC
GTTTTGGTTCTTGACCCGGGTTGTCCTGTTTGTATAGTCCCCCCTCTGTGGACGTGCTTTAGTAGCTCCTCTTACCTAGAGGGCTTTTAC
AGAGAATTAGAGCAACACCAAAAGGATTGCCTCTTTTCCTTCCTTCCCATTCCAAAATTCAGAGATGGCTTTGGGGCAAGTGCTACCTGT
GGAATAAACCTGTTTTCCAGGTGTCTCTTCTCCCAAGCACAAGAAGTCCTGGAGTCTTTGGAAGGTAGTCTGAATAGAAGGGTTTTCAGG
TGCAGGCATCTGAAAGCTGTGGGTATGTGTATAAATGATCAGGTCTGTGAGGCTAACACGGGCAAGAGGGAAAGAAAGGCTAACCATCCA
AACAGGGATACAGGGGAGGCGGTGGGGGGTGGTGGGGGGAGCGGGTGCTCACAAGCACAGAGCTGCCTGTTGTGAATGTCCCTGCTGCAA
AGTTGGTGGGTGAGAGAATGGGACTTCCTCTTTGAGAGTCTGGGGAGAGAAAAGGTGGCCAGGATCCTAGGACTGAATGACTCGATTTTA
CCTATTTGAGCTGCAGTCCTGTTTGCGCTCCTTGAATTGGTTAGGAAGCTGCTTCCTTTTCCCTCCTGCTTCCCTTCAGTCTCTTCAGGA
CCACAGGATGGATATGCAGACATGTGGGGTCATTGGGAAGGGAGTGCGCTTCTTTTCTCTGTCTTAGAAAAGGGAGTCAAGGGTTGGCTT
TGGAATTGGGCCTCTGGACAGAGTCAGAATGAGGGAATAATGAATAGGTCACATCTGGTTGGTGGAAAACTAGGTGAAGTGCTTCTTTAA
TATGCACTGTCTTGTCTTCCCACGCAAGATGTGACAATGTTTGAGAAAAGGTGTGTCATACTCAGTGACTTCAATTTGCAAATGTGGGGC
CTAAAGAAAGCTCTGCAGCTCTGAACCTCTCACTGGCCAGAGCTCAGCCTATTGGTCCCATCCATGATGCTGAGACAAACAGAAACTGGA
AGCTGAAGTCAGTGTCTCTGGTGCTCAGAAACCCTGTGGATTTCCCTCTGAACCAAGATTTTTAGTAGTAAAATAAACAACTCATGGACA
TCTGTCAGATGAGAAGTTTTGGTCCTGTTAGAGAGGAGAAAGACTGTAATGAAACTACTAGACCCATTTGGGCTAAAGTTTGGCTTTTCC
TTCCTTGAGTCATAGAACGTATCCATCTCCCAGGAAATGTCCTTCTCTGGCGTCTGCTTGCCCTTCTGAGTCTGCCTTTTTTGCACTGAA
CATAAGCACTTTATACTAATGGGTCACAAATCTTGCAGCCCTTAATTTGGGATAAGACCAGATTTTCCTGACATTTTCCTCTAACTCATT
GAACTATCAAATTATAGGCAACCACTGACTAGACTGATATGAGATGAGGCTAAAAGCCTTTGAACACCACGCTGTAGTCTCCAACAGAAA

>60991_60991_2_NUP155-ZFYVE26_NUP155_chr5_37370923_ENST00000513532_ZFYVE26_chr14_68244965_ENST00000347230_length(amino acids)=1046AA_BP=64
MTFSGPWCLRFPRCRLLCWARRCRPLHLPQPCRKLWKMLDGSSTVSCKRTACTRTFPSCLWCLPQEYELCEEWGCLYPIPREHLISLHQK
HLLHLLERRDHDKALQLLRRIPDPTMCLEVTEQSLDQHTSLATSHFLANYLTTHFYGQLTAVRHREIQALYVGSKILLTLPEQHRASYSH
LSSNPLFMLEQLLMNMKVDWATVAVQTLQQLLVGQEIGFTMDEVDSLLSRYAEKALDFPYPQREKRSDSVIHLQEIVHQAADPETLPRSP
SAEFSPAAPPGISSIHSPSLRERSFPPTQPSQEFVPPATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCSTKKMVV
EGCRENPARVCDQCYSYCNKDVPEEPSEKPEALDSSKNESPPYSFVVRVPKADEVEWILDLKEEENELVRSEFYYEQAPSASLCIAILNL
HRDSIACGHQLIEHCCRLSKGLTNPEVDAGLLTDIMKQLLFSAKMMFVKAGQSQDLALCDSYISKVDVLNILVAAAYRHVPSLDQILQPA
AVTRLRNQLLEAEYYQLGVEVSTKTGLDTTGAWHAWGMACLKAGNLTAAREKFSRCLKPPFDLNQLNHGSRLVQDVVEYLESTVRPFVSL
QDDDYFATLRELEATLRTQSLSLAVIPEGKIMNNTYYQECLFYLHNYSTNLAIISFYVRHSCLREALLHLLNKESPPEVFIEGIFQPSYK
SGKLHTLENLLESIDPTLESWGKYLIAACQHLQKKNYYHILYELQQFMKDQVRAAMTCIRFFSHKAKSYTELGEKLSWLLKAKDHLKIYL
QETSRSSGRKKTTFFRKKMTAADVSRHMNTLQLQMEVTRFLHRCESAGTSQITTLPLPTLFGNNHMKMDVACKVMLGGKNVEDGFGIAFR
VLQDFQLDAAMTYCRAARQLVEKEKYSEIQQLLKCVSESGMAAKSDGDTILLNCLEAFKRIPPQELEGLIQAIHNDDNKVRAYLICCKLR

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Fusion Gene PPI Analysis for NUP155-ZFYVE26

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for NUP155-ZFYVE26

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for NUP155-ZFYVE26

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source