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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NUP160-RBM6 (FusionGDB2 ID:60997)

Fusion Gene Summary for NUP160-RBM6

check button Fusion gene summary
Fusion gene informationFusion gene name: NUP160-RBM6
Fusion gene ID: 60997
HgeneTgene
Gene symbol

NUP160

RBM6

Gene ID

23279

10180

Gene namenucleoporin 160RNA binding motif protein 6
SynonymsNPHS193G2|DEF-3|DEF3|HLC-11|NY-LU-12|g16
Cytomap

11p11.2

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionnuclear pore complex protein Nup160160 kDa nucleoporinnucleoporin 160kDnucleoporin 160kDanucleoporin Nup160RNA-binding protein 6RNA-binding protein DEF-3lung cancer antigen NY-LU-12lung cancer protooncogene 11
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000378460, ENST00000526870, 
ENST00000532747, ENST00000530326, 
ENST00000528071, ENST00000528501, 
ENST00000531016, 		ENST00000421682, 
ENST00000422955, ENST00000441115, 
ENST00000266022, ENST00000442092, 
ENST00000443081, ENST00000539992, 
Fusion gene scores* DoF score9 X 8 X 6=43222 X 21 X 10=4620
# samples 1130
** MAII scorelog2(11/432*10)=-1.97352778863881
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(30/4620*10)=-3.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NUP160 [Title/Abstract] AND RBM6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNUP160(47869400)-RBM6(50114441), # samples:3
Anticipated loss of major functional domain due to fusion event.NUP160-RBM6 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NUP160-RBM6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
NUP160-RBM6 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNUP160

GO:0006406

mRNA export from nucleus

11684705


check buttonFusion gene breakpoints across NUP160 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RBM6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-N5-A4RA-01ANUP160chr11

47869400

-RBM6chr3

50114441

+
ChimerDB4UCSTCGA-N5-A4RANUP160chr11

47869399

-RBM6chr3

50114440

+
ChimerDB4UCSTCGA-N5-A4RANUP160chr11

47869400

-RBM6chr3

50114441

+


Top

Fusion Gene ORF analysis for NUP160-RBM6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000378460ENST00000421682NUP160chr11

47869400

-RBM6chr3

50114441

+
5CDS-intronENST00000378460ENST00000421682NUP160chr11

47869399

-RBM6chr3

50114440

+
5CDS-intronENST00000378460ENST00000422955NUP160chr11

47869400

-RBM6chr3

50114441

+
5CDS-intronENST00000378460ENST00000422955NUP160chr11

47869399

-RBM6chr3

50114440

+
5CDS-intronENST00000378460ENST00000441115NUP160chr11

47869400

-RBM6chr3

50114441

+
5CDS-intronENST00000378460ENST00000441115NUP160chr11

47869399

-RBM6chr3

50114440

+
5CDS-intronENST00000526870ENST00000421682NUP160chr11

47869400

-RBM6chr3

50114441

+
5CDS-intronENST00000526870ENST00000421682NUP160chr11

47869399

-RBM6chr3

50114440

+
5CDS-intronENST00000526870ENST00000422955NUP160chr11

47869400

-RBM6chr3

50114441

+
5CDS-intronENST00000526870ENST00000422955NUP160chr11

47869399

-RBM6chr3

50114440

+
5CDS-intronENST00000526870ENST00000441115NUP160chr11

47869400

-RBM6chr3

50114441

+
5CDS-intronENST00000526870ENST00000441115NUP160chr11

47869399

-RBM6chr3

50114440

+
5CDS-intronENST00000532747ENST00000421682NUP160chr11

47869400

-RBM6chr3

50114441

+
5CDS-intronENST00000532747ENST00000421682NUP160chr11

47869399

-RBM6chr3

50114440

+
5CDS-intronENST00000532747ENST00000422955NUP160chr11

47869400

-RBM6chr3

50114441

+
5CDS-intronENST00000532747ENST00000422955NUP160chr11

47869399

-RBM6chr3

50114440

+
5CDS-intronENST00000532747ENST00000441115NUP160chr11

47869400

-RBM6chr3

50114441

+
5CDS-intronENST00000532747ENST00000441115NUP160chr11

47869399

-RBM6chr3

50114440

+
5UTR-3CDSENST00000530326ENST00000266022NUP160chr11

47869400

-RBM6chr3

50114441

+
5UTR-3CDSENST00000530326ENST00000266022NUP160chr11

47869399

-RBM6chr3

50114440

+
5UTR-3CDSENST00000530326ENST00000442092NUP160chr11

47869400

-RBM6chr3

50114441

+
5UTR-3CDSENST00000530326ENST00000442092NUP160chr11

47869399

-RBM6chr3

50114440

+
5UTR-3CDSENST00000530326ENST00000443081NUP160chr11

47869400

-RBM6chr3

50114441

+
5UTR-3CDSENST00000530326ENST00000443081NUP160chr11

47869399

-RBM6chr3

50114440

+
5UTR-3CDSENST00000530326ENST00000539992NUP160chr11

47869400

-RBM6chr3

50114441

+
5UTR-3CDSENST00000530326ENST00000539992NUP160chr11

47869399

-RBM6chr3

50114440

+
5UTR-intronENST00000530326ENST00000421682NUP160chr11

47869400

-RBM6chr3

50114441

+
5UTR-intronENST00000530326ENST00000421682NUP160chr11

47869399

-RBM6chr3

50114440

+
5UTR-intronENST00000530326ENST00000422955NUP160chr11

47869400

-RBM6chr3

50114441

+
5UTR-intronENST00000530326ENST00000422955NUP160chr11

47869399

-RBM6chr3

50114440

+
5UTR-intronENST00000530326ENST00000441115NUP160chr11

47869400

-RBM6chr3

50114441

+
5UTR-intronENST00000530326ENST00000441115NUP160chr11

47869399

-RBM6chr3

50114440

+
Frame-shiftENST00000378460ENST00000266022NUP160chr11

47869400

-RBM6chr3

50114441

+
Frame-shiftENST00000378460ENST00000266022NUP160chr11

47869399

-RBM6chr3

50114440

+
Frame-shiftENST00000378460ENST00000442092NUP160chr11

47869400

-RBM6chr3

50114441

+
Frame-shiftENST00000378460ENST00000442092NUP160chr11

47869399

-RBM6chr3

50114440

+
Frame-shiftENST00000526870ENST00000266022NUP160chr11

47869400

-RBM6chr3

50114441

+
Frame-shiftENST00000526870ENST00000266022NUP160chr11

47869399

-RBM6chr3

50114440

+
Frame-shiftENST00000526870ENST00000442092NUP160chr11

47869400

-RBM6chr3

50114441

+
Frame-shiftENST00000526870ENST00000442092NUP160chr11

47869399

-RBM6chr3

50114440

+
Frame-shiftENST00000532747ENST00000442092NUP160chr11

47869400

-RBM6chr3

50114441

+
Frame-shiftENST00000532747ENST00000442092NUP160chr11

47869399

-RBM6chr3

50114440

+
Frame-shiftENST00000532747ENST00000443081NUP160chr11

47869400

-RBM6chr3

50114441

+
Frame-shiftENST00000532747ENST00000443081NUP160chr11

47869399

-RBM6chr3

50114440

+
Frame-shiftENST00000532747ENST00000539992NUP160chr11

47869400

-RBM6chr3

50114441

+
Frame-shiftENST00000532747ENST00000539992NUP160chr11

47869399

-RBM6chr3

50114440

+
In-frameENST00000378460ENST00000443081NUP160chr11

47869400

-RBM6chr3

50114441

+
In-frameENST00000378460ENST00000443081NUP160chr11

47869399

-RBM6chr3

50114440

+
In-frameENST00000378460ENST00000539992NUP160chr11

47869400

-RBM6chr3

50114441

+
In-frameENST00000378460ENST00000539992NUP160chr11

47869399

-RBM6chr3

50114440

+
In-frameENST00000526870ENST00000443081NUP160chr11

47869400

-RBM6chr3

50114441

+
In-frameENST00000526870ENST00000443081NUP160chr11

47869399

-RBM6chr3

50114440

+
In-frameENST00000526870ENST00000539992NUP160chr11

47869400

-RBM6chr3

50114441

+
In-frameENST00000526870ENST00000539992NUP160chr11

47869399

-RBM6chr3

50114440

+
In-frameENST00000532747ENST00000266022NUP160chr11

47869400

-RBM6chr3

50114441

+
In-frameENST00000532747ENST00000266022NUP160chr11

47869399

-RBM6chr3

50114440

+
intron-3CDSENST00000528071ENST00000266022NUP160chr11

47869400

-RBM6chr3

50114441

+
intron-3CDSENST00000528071ENST00000266022NUP160chr11

47869399

-RBM6chr3

50114440

+
intron-3CDSENST00000528071ENST00000442092NUP160chr11

47869400

-RBM6chr3

50114441

+
intron-3CDSENST00000528071ENST00000442092NUP160chr11

47869399

-RBM6chr3

50114440

+
intron-3CDSENST00000528071ENST00000443081NUP160chr11

47869400

-RBM6chr3

50114441

+
intron-3CDSENST00000528071ENST00000443081NUP160chr11

47869399

-RBM6chr3

50114440

+
intron-3CDSENST00000528071ENST00000539992NUP160chr11

47869400

-RBM6chr3

50114441

+
intron-3CDSENST00000528071ENST00000539992NUP160chr11

47869399

-RBM6chr3

50114440

+
intron-3CDSENST00000528501ENST00000266022NUP160chr11

47869400

-RBM6chr3

50114441

+
intron-3CDSENST00000528501ENST00000266022NUP160chr11

47869399

-RBM6chr3

50114440

+
intron-3CDSENST00000528501ENST00000442092NUP160chr11

47869400

-RBM6chr3

50114441

+
intron-3CDSENST00000528501ENST00000442092NUP160chr11

47869399

-RBM6chr3

50114440

+
intron-3CDSENST00000528501ENST00000443081NUP160chr11

47869400

-RBM6chr3

50114441

+
intron-3CDSENST00000528501ENST00000443081NUP160chr11

47869399

-RBM6chr3

50114440

+
intron-3CDSENST00000528501ENST00000539992NUP160chr11

47869400

-RBM6chr3

50114441

+
intron-3CDSENST00000528501ENST00000539992NUP160chr11

47869399

-RBM6chr3

50114440

+
intron-3CDSENST00000531016ENST00000266022NUP160chr11

47869400

-RBM6chr3

50114441

+
intron-3CDSENST00000531016ENST00000266022NUP160chr11

47869399

-RBM6chr3

50114440

+
intron-3CDSENST00000531016ENST00000442092NUP160chr11

47869400

-RBM6chr3

50114441

+
intron-3CDSENST00000531016ENST00000442092NUP160chr11

47869399

-RBM6chr3

50114440

+
intron-3CDSENST00000531016ENST00000443081NUP160chr11

47869400

-RBM6chr3

50114441

+
intron-3CDSENST00000531016ENST00000443081NUP160chr11

47869399

-RBM6chr3

50114440

+
intron-3CDSENST00000531016ENST00000539992NUP160chr11

47869400

-RBM6chr3

50114441

+
intron-3CDSENST00000531016ENST00000539992NUP160chr11

47869399

-RBM6chr3

50114440

+
intron-intronENST00000528071ENST00000421682NUP160chr11

47869400

-RBM6chr3

50114441

+
intron-intronENST00000528071ENST00000421682NUP160chr11

47869399

-RBM6chr3

50114440

+
intron-intronENST00000528071ENST00000422955NUP160chr11

47869400

-RBM6chr3

50114441

+
intron-intronENST00000528071ENST00000422955NUP160chr11

47869399

-RBM6chr3

50114440

+
intron-intronENST00000528071ENST00000441115NUP160chr11

47869400

-RBM6chr3

50114441

+
intron-intronENST00000528071ENST00000441115NUP160chr11

47869399

-RBM6chr3

50114440

+
intron-intronENST00000528501ENST00000421682NUP160chr11

47869400

-RBM6chr3

50114441

+
intron-intronENST00000528501ENST00000421682NUP160chr11

47869399

-RBM6chr3

50114440

+
intron-intronENST00000528501ENST00000422955NUP160chr11

47869400

-RBM6chr3

50114441

+
intron-intronENST00000528501ENST00000422955NUP160chr11

47869399

-RBM6chr3

50114440

+
intron-intronENST00000528501ENST00000441115NUP160chr11

47869400

-RBM6chr3

50114441

+
intron-intronENST00000528501ENST00000441115NUP160chr11

47869399

-RBM6chr3

50114440

+
intron-intronENST00000531016ENST00000421682NUP160chr11

47869400

-RBM6chr3

50114441

+
intron-intronENST00000531016ENST00000421682NUP160chr11

47869399

-RBM6chr3

50114440

+
intron-intronENST00000531016ENST00000422955NUP160chr11

47869400

-RBM6chr3

50114441

+
intron-intronENST00000531016ENST00000422955NUP160chr11

47869399

-RBM6chr3

50114440

+
intron-intronENST00000531016ENST00000441115NUP160chr11

47869400

-RBM6chr3

50114441

+
intron-intronENST00000531016ENST00000441115NUP160chr11

47869399

-RBM6chr3

50114440

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000378460NUP160chr1147869400-ENST00000443081RBM6chr350114441+60236147376109
ENST00000378460NUP160chr1147869400-ENST00000539992RBM6chr350114441+60236147376109
ENST00000532747NUP160chr1147869400-ENST00000266022RBM6chr350114441+4672241223975
ENST00000526870NUP160chr1147869400-ENST00000443081RBM6chr350114441+690449135464109
ENST00000526870NUP160chr1147869400-ENST00000539992RBM6chr350114441+690449135464109
ENST00000378460NUP160chr1147869399-ENST00000443081RBM6chr350114440+60236147376109
ENST00000378460NUP160chr1147869399-ENST00000539992RBM6chr350114440+60236147376109
ENST00000532747NUP160chr1147869399-ENST00000266022RBM6chr350114440+4672241223975
ENST00000526870NUP160chr1147869399-ENST00000443081RBM6chr350114440+690449135464109
ENST00000526870NUP160chr1147869399-ENST00000539992RBM6chr350114440+690449135464109

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000378460ENST00000443081NUP160chr1147869400-RBM6chr350114441+0.49501630.5049837
ENST00000378460ENST00000539992NUP160chr1147869400-RBM6chr350114441+0.49501630.5049837
ENST00000532747ENST00000266022NUP160chr1147869400-RBM6chr350114441+0.30772050.69227946
ENST00000526870ENST00000443081NUP160chr1147869400-RBM6chr350114441+0.56729880.43270117
ENST00000526870ENST00000539992NUP160chr1147869400-RBM6chr350114441+0.56729880.43270117
ENST00000378460ENST00000443081NUP160chr1147869399-RBM6chr350114440+0.49501630.5049837
ENST00000378460ENST00000539992NUP160chr1147869399-RBM6chr350114440+0.49501630.5049837
ENST00000532747ENST00000266022NUP160chr1147869399-RBM6chr350114440+0.30772050.69227946
ENST00000526870ENST00000443081NUP160chr1147869399-RBM6chr350114440+0.56729880.43270117
ENST00000526870ENST00000539992NUP160chr1147869399-RBM6chr350114440+0.56729880.43270117

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Fusion Genomic Features for NUP160-RBM6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NUP160chr1147869399-RBM6chr350114440+2.47E-111
NUP160chr1147869399-RBM6chr350114440+2.47E-111
NUP160chr1147869399-RBM6chr350114440+2.47E-111
NUP160chr1147869399-RBM6chr350114440+2.47E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for NUP160-RBM6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:47869400/chr3:50114441)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRBM6chr11:47869399chr3:50114440ENST000004229551719826_829560602.0Compositional biasNote=Poly-Glu
TgeneRBM6chr11:47869399chr3:50114440ENST000004229551719892_895560602.0Compositional biasNote=Poly-Pro
TgeneRBM6chr11:47869399chr3:50114440ENST000004229551719915_921560602.0Compositional biasNote=Poly-Glu
TgeneRBM6chr11:47869399chr3:50114440ENST000004420921517826_829560602.0Compositional biasNote=Poly-Glu
TgeneRBM6chr11:47869399chr3:50114440ENST000004420921517892_895560602.0Compositional biasNote=Poly-Pro
TgeneRBM6chr11:47869399chr3:50114440ENST000004420921517915_921560602.0Compositional biasNote=Poly-Glu
TgeneRBM6chr11:47869400chr3:50114441ENST000004229551719826_829560602.0Compositional biasNote=Poly-Glu
TgeneRBM6chr11:47869400chr3:50114441ENST000004229551719892_895560602.0Compositional biasNote=Poly-Pro
TgeneRBM6chr11:47869400chr3:50114441ENST000004229551719915_921560602.0Compositional biasNote=Poly-Glu
TgeneRBM6chr11:47869400chr3:50114441ENST000004420921517826_829560602.0Compositional biasNote=Poly-Glu
TgeneRBM6chr11:47869400chr3:50114441ENST000004420921517892_895560602.0Compositional biasNote=Poly-Pro
TgeneRBM6chr11:47869400chr3:50114441ENST000004420921517915_921560602.0Compositional biasNote=Poly-Glu
TgeneRBM6chr11:47869399chr3:50114440ENST0000042295517191051_1097560602.0DomainG-patch
TgeneRBM6chr11:47869399chr3:50114440ENST0000044209215171051_1097560602.0DomainG-patch
TgeneRBM6chr11:47869400chr3:50114441ENST0000042295517191051_1097560602.0DomainG-patch
TgeneRBM6chr11:47869400chr3:50114441ENST0000044209215171051_1097560602.0DomainG-patch

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRBM6chr11:47869399chr3:50114440ENST000002660221921826_82910821124.0Compositional biasNote=Poly-Glu
TgeneRBM6chr11:47869399chr3:50114440ENST000002660221921892_89510821124.0Compositional biasNote=Poly-Pro
TgeneRBM6chr11:47869399chr3:50114440ENST000002660221921915_92110821124.0Compositional biasNote=Poly-Glu
TgeneRBM6chr11:47869400chr3:50114441ENST000002660221921826_82910821124.0Compositional biasNote=Poly-Glu
TgeneRBM6chr11:47869400chr3:50114441ENST000002660221921892_89510821124.0Compositional biasNote=Poly-Pro
TgeneRBM6chr11:47869400chr3:50114441ENST000002660221921915_92110821124.0Compositional biasNote=Poly-Glu
TgeneRBM6chr11:47869399chr3:50114440ENST0000026602219211051_109710821124.0DomainG-patch
TgeneRBM6chr11:47869399chr3:50114440ENST000002660221921456_53610821124.0DomainRRM
TgeneRBM6chr11:47869399chr3:50114440ENST000004229551719456_536560602.0DomainRRM
TgeneRBM6chr11:47869399chr3:50114440ENST000004420921517456_536560602.0DomainRRM
TgeneRBM6chr11:47869400chr3:50114441ENST0000026602219211051_109710821124.0DomainG-patch
TgeneRBM6chr11:47869400chr3:50114441ENST000002660221921456_53610821124.0DomainRRM
TgeneRBM6chr11:47869400chr3:50114441ENST000004229551719456_536560602.0DomainRRM
TgeneRBM6chr11:47869400chr3:50114441ENST000004420921517456_536560602.0DomainRRM


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Fusion Gene Sequence for NUP160-RBM6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>60997_60997_1_NUP160-RBM6_NUP160_chr11_47869399_ENST00000378460_RBM6_chr3_50114440_ENST00000443081_length(transcript)=602nt_BP=361nt
GTGGAAGCCTCGCAACGAAGGGCCGGAGCCGCCTTTCTGCTCCCGGAATGCTTCACCTGTCCGCAGCTCCGCCCGCCCCACCCCCGGAAG
TGACGGCGACCGCGCGGCCCTGCCTTTGTTCCGTTGGGCGTCGCGGCGACGGCGGGAAGATGGCGGCGGCGGGAGCCCTGGAACGGAGCT
TCGTGGAGCTAAGCGGAGCTGAGCGCGAAAGGCCGAGGCACTTTCGGGAATTCACAGTCTGCAGCATTGGGACTGCAAATGCCGTGGCTG
GCGCCGTAAAATACAGTGAAAGCGCGGGAGGCTTTTACTACGTGGAGAGTGGCAAGTTGTTCTCCGTAACCAGAAACAGGTTCATTCATT
GGCTGAAGGCCGGATGAGGGGCCCCAGTGTTGGAGCCTCAGGAAGAACCAGCAAAAGACAGTCCAACGAGACTTACCGAGATGCTGTTCG
AAGAGTCATGTTTGCTCGATATAAAGAACTCGATTAAGAAAGGAGACAAGTTCCATGGGATACAACCTCCCTCTTGTTTTGTTTGTCTCT

>60997_60997_1_NUP160-RBM6_NUP160_chr11_47869399_ENST00000378460_RBM6_chr3_50114440_ENST00000443081_length(amino acids)=109AA_BP=
MLHLSAAPPAPPPEVTATARPCLCSVGRRGDGGKMAAAGALERSFVELSGAERERPRHFREFTVCSIGTANAVAGAVKYSESAGGFYYVE

--------------------------------------------------------------
>60997_60997_2_NUP160-RBM6_NUP160_chr11_47869399_ENST00000378460_RBM6_chr3_50114440_ENST00000539992_length(transcript)=602nt_BP=361nt
GTGGAAGCCTCGCAACGAAGGGCCGGAGCCGCCTTTCTGCTCCCGGAATGCTTCACCTGTCCGCAGCTCCGCCCGCCCCACCCCCGGAAG
TGACGGCGACCGCGCGGCCCTGCCTTTGTTCCGTTGGGCGTCGCGGCGACGGCGGGAAGATGGCGGCGGCGGGAGCCCTGGAACGGAGCT
TCGTGGAGCTAAGCGGAGCTGAGCGCGAAAGGCCGAGGCACTTTCGGGAATTCACAGTCTGCAGCATTGGGACTGCAAATGCCGTGGCTG
GCGCCGTAAAATACAGTGAAAGCGCGGGAGGCTTTTACTACGTGGAGAGTGGCAAGTTGTTCTCCGTAACCAGAAACAGGTTCATTCATT
GGCTGAAGGCCGGATGAGGGGCCCCAGTGTTGGAGCCTCAGGAAGAACCAGCAAAAGACAGTCCAACGAGACTTACCGAGATGCTGTTCG
AAGAGTCATGTTTGCTCGATATAAAGAACTCGATTAAGAAAGGAGACAAGTTCCATGGGATACAACCTCCCTCTTGTTTTGTTTGTCTCT

>60997_60997_2_NUP160-RBM6_NUP160_chr11_47869399_ENST00000378460_RBM6_chr3_50114440_ENST00000539992_length(amino acids)=109AA_BP=
MLHLSAAPPAPPPEVTATARPCLCSVGRRGDGGKMAAAGALERSFVELSGAERERPRHFREFTVCSIGTANAVAGAVKYSESAGGFYYVE

--------------------------------------------------------------
>60997_60997_3_NUP160-RBM6_NUP160_chr11_47869399_ENST00000526870_RBM6_chr3_50114440_ENST00000443081_length(transcript)=690nt_BP=449nt
CCGGCCACTGGAAGGTTCCCGCAGATAGAGTCTGCCTCCCCTGCCCCCTTCTCTTCTGGATTCCTCGCTGCCCACCCTCATTCTCCCGGT
GGAAGCCTCGCAACGAAGGGCCGGAGCCGCCTTTCTGCTCCCGGAATGCTTCACCTGTCCGCAGCTCCGCCCGCCCCACCCCCGGAAGTG
ACGGCGACCGCGCGGCCCTGCCTTTGTTCCGTTGGGCGTCGCGGCGACGGCGGGAAGATGGCGGCGGCGGGAGCCCTGGAACGGAGCTTC
GTGGAGCTAAGCGGAGCTGAGCGCGAAAGGCCGAGGCACTTTCGGGAATTCACAGTCTGCAGCATTGGGACTGCAAATGCCGTGGCTGGC
GCCGTAAAATACAGTGAAAGCGCGGGAGGCTTTTACTACGTGGAGAGTGGCAAGTTGTTCTCCGTAACCAGAAACAGGTTCATTCATTGG
CTGAAGGCCGGATGAGGGGCCCCAGTGTTGGAGCCTCAGGAAGAACCAGCAAAAGACAGTCCAACGAGACTTACCGAGATGCTGTTCGAA
GAGTCATGTTTGCTCGATATAAAGAACTCGATTAAGAAAGGAGACAAGTTCCATGGGATACAACCTCCCTCTTGTTTTGTTTGTCTCTCC

>60997_60997_3_NUP160-RBM6_NUP160_chr11_47869399_ENST00000526870_RBM6_chr3_50114440_ENST00000443081_length(amino acids)=109AA_BP=
MLHLSAAPPAPPPEVTATARPCLCSVGRRGDGGKMAAAGALERSFVELSGAERERPRHFREFTVCSIGTANAVAGAVKYSESAGGFYYVE

--------------------------------------------------------------
>60997_60997_4_NUP160-RBM6_NUP160_chr11_47869399_ENST00000526870_RBM6_chr3_50114440_ENST00000539992_length(transcript)=690nt_BP=449nt
CCGGCCACTGGAAGGTTCCCGCAGATAGAGTCTGCCTCCCCTGCCCCCTTCTCTTCTGGATTCCTCGCTGCCCACCCTCATTCTCCCGGT
GGAAGCCTCGCAACGAAGGGCCGGAGCCGCCTTTCTGCTCCCGGAATGCTTCACCTGTCCGCAGCTCCGCCCGCCCCACCCCCGGAAGTG
ACGGCGACCGCGCGGCCCTGCCTTTGTTCCGTTGGGCGTCGCGGCGACGGCGGGAAGATGGCGGCGGCGGGAGCCCTGGAACGGAGCTTC
GTGGAGCTAAGCGGAGCTGAGCGCGAAAGGCCGAGGCACTTTCGGGAATTCACAGTCTGCAGCATTGGGACTGCAAATGCCGTGGCTGGC
GCCGTAAAATACAGTGAAAGCGCGGGAGGCTTTTACTACGTGGAGAGTGGCAAGTTGTTCTCCGTAACCAGAAACAGGTTCATTCATTGG
CTGAAGGCCGGATGAGGGGCCCCAGTGTTGGAGCCTCAGGAAGAACCAGCAAAAGACAGTCCAACGAGACTTACCGAGATGCTGTTCGAA
GAGTCATGTTTGCTCGATATAAAGAACTCGATTAAGAAAGGAGACAAGTTCCATGGGATACAACCTCCCTCTTGTTTTGTTTGTCTCTCC

>60997_60997_4_NUP160-RBM6_NUP160_chr11_47869399_ENST00000526870_RBM6_chr3_50114440_ENST00000539992_length(amino acids)=109AA_BP=
MLHLSAAPPAPPPEVTATARPCLCSVGRRGDGGKMAAAGALERSFVELSGAERERPRHFREFTVCSIGTANAVAGAVKYSESAGGFYYVE

--------------------------------------------------------------
>60997_60997_5_NUP160-RBM6_NUP160_chr11_47869399_ENST00000532747_RBM6_chr3_50114440_ENST00000266022_length(transcript)=467nt_BP=224nt
GACGGCGGGAAGATGGCGGCGGCGGGAGCCCTGGAACGGAGCTTCGTGGAGCTAAGCGGAGCTGAGCGCGAAAGGCCGAGGCACTTTCGG
GAATTCACAGTCTGCAGCATTGGGACTGCAAATGCCGTGGCTGGCGCCGTAAAATACAGTGAAAGCGCGGGAGGCTTTTACTACGTGGAG
AGTGGCAAGTTGTTCTCCGTAACCAGAAACAGGTTCATTCATTGGCTGAAGGCCGGATGAGGGGCCCCAGTGTTGGAGCCTCAGGAAGAA
CCAGCAAAAGACAGTCCAACGAGACTTACCGAGATGCTGTTCGAAGAGTCATGTTTGCTCGATATAAAGAACTCGATTAAGAAAGGAGAC
AAGTTCCATGGGATACAACCTCCCTCTTGTTTTGTTTGTCTCTCCTTTTCTTTTGTTACTGTTCTTGCTGCTAGAACTTTTTTAAATAAA

>60997_60997_5_NUP160-RBM6_NUP160_chr11_47869399_ENST00000532747_RBM6_chr3_50114440_ENST00000266022_length(amino acids)=75AA_BP=

--------------------------------------------------------------
>60997_60997_6_NUP160-RBM6_NUP160_chr11_47869400_ENST00000378460_RBM6_chr3_50114441_ENST00000443081_length(transcript)=602nt_BP=361nt
GTGGAAGCCTCGCAACGAAGGGCCGGAGCCGCCTTTCTGCTCCCGGAATGCTTCACCTGTCCGCAGCTCCGCCCGCCCCACCCCCGGAAG
TGACGGCGACCGCGCGGCCCTGCCTTTGTTCCGTTGGGCGTCGCGGCGACGGCGGGAAGATGGCGGCGGCGGGAGCCCTGGAACGGAGCT
TCGTGGAGCTAAGCGGAGCTGAGCGCGAAAGGCCGAGGCACTTTCGGGAATTCACAGTCTGCAGCATTGGGACTGCAAATGCCGTGGCTG
GCGCCGTAAAATACAGTGAAAGCGCGGGAGGCTTTTACTACGTGGAGAGTGGCAAGTTGTTCTCCGTAACCAGAAACAGGTTCATTCATT
GGCTGAAGGCCGGATGAGGGGCCCCAGTGTTGGAGCCTCAGGAAGAACCAGCAAAAGACAGTCCAACGAGACTTACCGAGATGCTGTTCG
AAGAGTCATGTTTGCTCGATATAAAGAACTCGATTAAGAAAGGAGACAAGTTCCATGGGATACAACCTCCCTCTTGTTTTGTTTGTCTCT

>60997_60997_6_NUP160-RBM6_NUP160_chr11_47869400_ENST00000378460_RBM6_chr3_50114441_ENST00000443081_length(amino acids)=109AA_BP=
MLHLSAAPPAPPPEVTATARPCLCSVGRRGDGGKMAAAGALERSFVELSGAERERPRHFREFTVCSIGTANAVAGAVKYSESAGGFYYVE

--------------------------------------------------------------
>60997_60997_7_NUP160-RBM6_NUP160_chr11_47869400_ENST00000378460_RBM6_chr3_50114441_ENST00000539992_length(transcript)=602nt_BP=361nt
GTGGAAGCCTCGCAACGAAGGGCCGGAGCCGCCTTTCTGCTCCCGGAATGCTTCACCTGTCCGCAGCTCCGCCCGCCCCACCCCCGGAAG
TGACGGCGACCGCGCGGCCCTGCCTTTGTTCCGTTGGGCGTCGCGGCGACGGCGGGAAGATGGCGGCGGCGGGAGCCCTGGAACGGAGCT
TCGTGGAGCTAAGCGGAGCTGAGCGCGAAAGGCCGAGGCACTTTCGGGAATTCACAGTCTGCAGCATTGGGACTGCAAATGCCGTGGCTG
GCGCCGTAAAATACAGTGAAAGCGCGGGAGGCTTTTACTACGTGGAGAGTGGCAAGTTGTTCTCCGTAACCAGAAACAGGTTCATTCATT
GGCTGAAGGCCGGATGAGGGGCCCCAGTGTTGGAGCCTCAGGAAGAACCAGCAAAAGACAGTCCAACGAGACTTACCGAGATGCTGTTCG
AAGAGTCATGTTTGCTCGATATAAAGAACTCGATTAAGAAAGGAGACAAGTTCCATGGGATACAACCTCCCTCTTGTTTTGTTTGTCTCT

>60997_60997_7_NUP160-RBM6_NUP160_chr11_47869400_ENST00000378460_RBM6_chr3_50114441_ENST00000539992_length(amino acids)=109AA_BP=
MLHLSAAPPAPPPEVTATARPCLCSVGRRGDGGKMAAAGALERSFVELSGAERERPRHFREFTVCSIGTANAVAGAVKYSESAGGFYYVE

--------------------------------------------------------------
>60997_60997_8_NUP160-RBM6_NUP160_chr11_47869400_ENST00000526870_RBM6_chr3_50114441_ENST00000443081_length(transcript)=690nt_BP=449nt
CCGGCCACTGGAAGGTTCCCGCAGATAGAGTCTGCCTCCCCTGCCCCCTTCTCTTCTGGATTCCTCGCTGCCCACCCTCATTCTCCCGGT
GGAAGCCTCGCAACGAAGGGCCGGAGCCGCCTTTCTGCTCCCGGAATGCTTCACCTGTCCGCAGCTCCGCCCGCCCCACCCCCGGAAGTG
ACGGCGACCGCGCGGCCCTGCCTTTGTTCCGTTGGGCGTCGCGGCGACGGCGGGAAGATGGCGGCGGCGGGAGCCCTGGAACGGAGCTTC
GTGGAGCTAAGCGGAGCTGAGCGCGAAAGGCCGAGGCACTTTCGGGAATTCACAGTCTGCAGCATTGGGACTGCAAATGCCGTGGCTGGC
GCCGTAAAATACAGTGAAAGCGCGGGAGGCTTTTACTACGTGGAGAGTGGCAAGTTGTTCTCCGTAACCAGAAACAGGTTCATTCATTGG
CTGAAGGCCGGATGAGGGGCCCCAGTGTTGGAGCCTCAGGAAGAACCAGCAAAAGACAGTCCAACGAGACTTACCGAGATGCTGTTCGAA
GAGTCATGTTTGCTCGATATAAAGAACTCGATTAAGAAAGGAGACAAGTTCCATGGGATACAACCTCCCTCTTGTTTTGTTTGTCTCTCC

>60997_60997_8_NUP160-RBM6_NUP160_chr11_47869400_ENST00000526870_RBM6_chr3_50114441_ENST00000443081_length(amino acids)=109AA_BP=
MLHLSAAPPAPPPEVTATARPCLCSVGRRGDGGKMAAAGALERSFVELSGAERERPRHFREFTVCSIGTANAVAGAVKYSESAGGFYYVE

--------------------------------------------------------------
>60997_60997_9_NUP160-RBM6_NUP160_chr11_47869400_ENST00000526870_RBM6_chr3_50114441_ENST00000539992_length(transcript)=690nt_BP=449nt
CCGGCCACTGGAAGGTTCCCGCAGATAGAGTCTGCCTCCCCTGCCCCCTTCTCTTCTGGATTCCTCGCTGCCCACCCTCATTCTCCCGGT
GGAAGCCTCGCAACGAAGGGCCGGAGCCGCCTTTCTGCTCCCGGAATGCTTCACCTGTCCGCAGCTCCGCCCGCCCCACCCCCGGAAGTG
ACGGCGACCGCGCGGCCCTGCCTTTGTTCCGTTGGGCGTCGCGGCGACGGCGGGAAGATGGCGGCGGCGGGAGCCCTGGAACGGAGCTTC
GTGGAGCTAAGCGGAGCTGAGCGCGAAAGGCCGAGGCACTTTCGGGAATTCACAGTCTGCAGCATTGGGACTGCAAATGCCGTGGCTGGC
GCCGTAAAATACAGTGAAAGCGCGGGAGGCTTTTACTACGTGGAGAGTGGCAAGTTGTTCTCCGTAACCAGAAACAGGTTCATTCATTGG
CTGAAGGCCGGATGAGGGGCCCCAGTGTTGGAGCCTCAGGAAGAACCAGCAAAAGACAGTCCAACGAGACTTACCGAGATGCTGTTCGAA
GAGTCATGTTTGCTCGATATAAAGAACTCGATTAAGAAAGGAGACAAGTTCCATGGGATACAACCTCCCTCTTGTTTTGTTTGTCTCTCC

>60997_60997_9_NUP160-RBM6_NUP160_chr11_47869400_ENST00000526870_RBM6_chr3_50114441_ENST00000539992_length(amino acids)=109AA_BP=
MLHLSAAPPAPPPEVTATARPCLCSVGRRGDGGKMAAAGALERSFVELSGAERERPRHFREFTVCSIGTANAVAGAVKYSESAGGFYYVE

--------------------------------------------------------------
>60997_60997_10_NUP160-RBM6_NUP160_chr11_47869400_ENST00000532747_RBM6_chr3_50114441_ENST00000266022_length(transcript)=467nt_BP=224nt
GACGGCGGGAAGATGGCGGCGGCGGGAGCCCTGGAACGGAGCTTCGTGGAGCTAAGCGGAGCTGAGCGCGAAAGGCCGAGGCACTTTCGG
GAATTCACAGTCTGCAGCATTGGGACTGCAAATGCCGTGGCTGGCGCCGTAAAATACAGTGAAAGCGCGGGAGGCTTTTACTACGTGGAG
AGTGGCAAGTTGTTCTCCGTAACCAGAAACAGGTTCATTCATTGGCTGAAGGCCGGATGAGGGGCCCCAGTGTTGGAGCCTCAGGAAGAA
CCAGCAAAAGACAGTCCAACGAGACTTACCGAGATGCTGTTCGAAGAGTCATGTTTGCTCGATATAAAGAACTCGATTAAGAAAGGAGAC
AAGTTCCATGGGATACAACCTCCCTCTTGTTTTGTTTGTCTCTCCTTTTCTTTTGTTACTGTTCTTGCTGCTAGAACTTTTTTAAATAAA

>60997_60997_10_NUP160-RBM6_NUP160_chr11_47869400_ENST00000532747_RBM6_chr3_50114441_ENST00000266022_length(amino acids)=75AA_BP=

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NUP160-RBM6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NUP160-RBM6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NUP160-RBM6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource