FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:NUP205-TPM1 (FusionGDB2 ID:61021)

Fusion Gene Summary for NUP205-TPM1

check button Fusion gene summary
Fusion gene informationFusion gene name: NUP205-TPM1
Fusion gene ID: 61021
HgeneTgene
Gene symbol

NUP205

TPM1

Gene ID

23165

7168

Gene namenucleoporin 205tropomyosin 1
SynonymsC7orf14|NPHS13C15orf13|CMD1Y|CMH3|HEL-S-265|HTM-alpha|LVNC9|TMSA
Cytomap

7q33

15q22.2

Type of geneprotein-codingprotein-coding
Descriptionnuclear pore complex protein Nup205205 kDa nucleoporinnucleoporin Nup205tropomyosin alpha-1 chaincardiomyopathy, hypertrophic 3epididymis secretory protein Li 265sarcomeric tropomyosin kappa
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000285968, ENST00000440390, 
ENST00000489493, 
ENST00000267996, 
ENST00000317516, ENST00000334895, 
ENST00000357980, ENST00000403994, 
ENST00000404484, ENST00000559281, 
ENST00000559397, ENST00000559556, 
ENST00000560445, ENST00000560959, 
ENST00000288398, ENST00000358278, 
Fusion gene scores* DoF score8 X 9 X 7=50414 X 8 X 8=896
# samples 916
** MAII scorelog2(9/504*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(16/896*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NUP205 [Title/Abstract] AND TPM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNUP205(135269755)-TPM1(63349184), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NUP205 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TPM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8364-01ANUP205chr7

135269755

+TPM1chr15

63349184

+


Top

Fusion Gene ORF analysis for NUP205-TPM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000285968ENST00000267996NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000285968ENST00000317516NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000285968ENST00000334895NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000285968ENST00000357980NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000285968ENST00000403994NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000285968ENST00000404484NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000285968ENST00000559281NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000285968ENST00000559397NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000285968ENST00000559556NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000285968ENST00000560445NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000285968ENST00000560959NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000440390ENST00000267996NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000440390ENST00000317516NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000440390ENST00000334895NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000440390ENST00000357980NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000440390ENST00000403994NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000440390ENST00000404484NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000440390ENST00000559281NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000440390ENST00000559397NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000440390ENST00000559556NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000440390ENST00000560445NUP205chr7

135269755

+TPM1chr15

63349184

+
5CDS-intronENST00000440390ENST00000560959NUP205chr7

135269755

+TPM1chr15

63349184

+
In-frameENST00000285968ENST00000288398NUP205chr7

135269755

+TPM1chr15

63349184

+
In-frameENST00000285968ENST00000358278NUP205chr7

135269755

+TPM1chr15

63349184

+
In-frameENST00000440390ENST00000288398NUP205chr7

135269755

+TPM1chr15

63349184

+
In-frameENST00000440390ENST00000358278NUP205chr7

135269755

+TPM1chr15

63349184

+
intron-3CDSENST00000489493ENST00000288398NUP205chr7

135269755

+TPM1chr15

63349184

+
intron-3CDSENST00000489493ENST00000358278NUP205chr7

135269755

+TPM1chr15

63349184

+
intron-intronENST00000489493ENST00000267996NUP205chr7

135269755

+TPM1chr15

63349184

+
intron-intronENST00000489493ENST00000317516NUP205chr7

135269755

+TPM1chr15

63349184

+
intron-intronENST00000489493ENST00000334895NUP205chr7

135269755

+TPM1chr15

63349184

+
intron-intronENST00000489493ENST00000357980NUP205chr7

135269755

+TPM1chr15

63349184

+
intron-intronENST00000489493ENST00000403994NUP205chr7

135269755

+TPM1chr15

63349184

+
intron-intronENST00000489493ENST00000404484NUP205chr7

135269755

+TPM1chr15

63349184

+
intron-intronENST00000489493ENST00000559281NUP205chr7

135269755

+TPM1chr15

63349184

+
intron-intronENST00000489493ENST00000559397NUP205chr7

135269755

+TPM1chr15

63349184

+
intron-intronENST00000489493ENST00000559556NUP205chr7

135269755

+TPM1chr15

63349184

+
intron-intronENST00000489493ENST00000560445NUP205chr7

135269755

+TPM1chr15

63349184

+
intron-intronENST00000489493ENST00000560959NUP205chr7

135269755

+TPM1chr15

63349184

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000285968NUP205chr7135269755+ENST00000288398TPM1chr1563349184+21011244261858610
ENST00000285968NUP205chr7135269755+ENST00000358278TPM1chr1563349184+25761244261858610
ENST00000440390NUP205chr7135269755+ENST00000288398TPM1chr1563349184+206012036031817404
ENST00000440390NUP205chr7135269755+ENST00000358278TPM1chr1563349184+253512036031817404

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000285968ENST00000288398NUP205chr7135269755+TPM1chr1563349184+0.0078216380.9921783
ENST00000285968ENST00000358278NUP205chr7135269755+TPM1chr1563349184+0.0029495470.9970504
ENST00000440390ENST00000288398NUP205chr7135269755+TPM1chr1563349184+0.0021110010.997889
ENST00000440390ENST00000358278NUP205chr7135269755+TPM1chr1563349184+0.0006336270.99936634

Top

Fusion Genomic Features for NUP205-TPM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NUP205chr7135269755+TPM1chr1563349183+1.47E-121
NUP205chr7135269755+TPM1chr1563349183+1.47E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for NUP205-TPM1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:135269755/chr15:63349184)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTPM1chr7:135269755chr15:63349184ENST00000267996191_28480285.0Coiled coilOntology_term=ECO:0000250
TgeneTPM1chr7:135269755chr15:63349184ENST000002883981101_28480247.0Coiled coilOntology_term=ECO:0000250
TgeneTPM1chr7:135269755chr15:63349184ENST00000334895081_28444246.0Coiled coilOntology_term=ECO:0000250
TgeneTPM1chr7:135269755chr15:63349184ENST00000358278191_28480285.0Coiled coilOntology_term=ECO:0000250
TgeneTPM1chr7:135269755chr15:63349184ENST000004039941101_28480285.0Coiled coilOntology_term=ECO:0000250
TgeneTPM1chr7:135269755chr15:63349184ENST00000559397191_28480285.0Coiled coilOntology_term=ECO:0000250
TgeneTPM1chr7:135269755chr15:63349184ENST00000559556191_28480285.0Coiled coilOntology_term=ECO:0000250


Top

Fusion Gene Sequence for NUP205-TPM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>61021_61021_1_NUP205-TPM1_NUP205_chr7_135269755_ENST00000285968_TPM1_chr15_63349184_ENST00000288398_length(transcript)=2101nt_BP=1244nt
AAGGGCTCTGTTAGTGCGCCTCTAAGATGGCGACGCCTTTGGCGGTAAATTCGGCTGCTAGTCTATGGGGTCCTTACAAAGACATTTGGC
ATAAAGTGGGAAATGCTCTTTGGAGAAGACAACCTGAAGCTGTTCACCTTCTTGATAAGATTTTGAAGAAACACAAACCTGACTTCATCT
CATTGTTCAAAAATCCGCCAAAAAATGTTCAACAGCATGAGAAGGTTCAGAAAGCCAGTACAGAGGGAGTCGCCATTCAGGGTCAACAGG
GAACTCGACTTCTTCCTGAACAGCTCATTAAAGAAGCCTTTATTCTCAGTGACCTTTTTGATATTGGAGAATTGGCAGCTGTTGAGCTTC
TTCTTGCTGGAGAGCATCAACAGCCACATTTTCCTGGCCTTACCAGAGGATTAGTAGCTGTTCTTCTGTACTGGGATGGAAAGCGATGCA
TTGCGAATTCCTTGAAAGCCTTGATACAGTCTAGACGGGGAAAGACATGGACCCTAGAACTCAGTCCAGAGCTGGCTTCCATGACAACAC
GCTTTACAGATGAGCTGATGGAGCAAGGATTGACTTATAAAGTTCTTACGCTGGTGTCACAGATTGATGTGAATAATGAGTTTGAGAAAC
TACAGCGAGAGAGAGGTTTGGGCAGTGAAAAACATCGCAAAGAGGTTTCTGATCTCATTAAGGAGTGCAGGCAGTCTCTTGCAGAAAGCC
TTTTTGCCTGGGCTTGCCAGTCACCTTTAGGCAAAGAAGACACTCTCCTCCTCATTGGACATTTGGAAAGAGTGACAGTTGAGGCTAATG
GCTCACTGGATGCAGTGAATCTGGCTCTTCTTATGGCGCTTCTATACTGTTTTGATATCAGTTTTATAGAGCAAAGCACAGAGGAACGAG
ATGATATGATTCATCAACTTCCACTGTTGACAGAAAAACAGTACATTGCAACAATTCACTCTCGTCTTCAGGACTCACAGCTTTGGAAAC
TGCCTGGGCTCCAAGCCACTGTTAGACTTGCCTGGGCGCTGGCATTGAGGGGAATATCCCAGCTACCTGATGTGACAGCTCTGGCAGAAT
TCACAGAGGCAGATGAAGCAATGGCAGAACTCGCAATTGCTGACAACGTTTTCCTGTTCCTCATGGAATCTGTAGTGGTATCAGAATACT
TTTATCAGGAAGAATTTTATATTCGCAGAGTCCATAATCTCATCACAGATTTCCTTGCACTTATGCCAATGAAGGCTGAAGCCGACGTAG
CTTCTCTGAACAGACGCATCCAGCTGGTTGAGGAAGAGTTGGATCGTGCCCAGGAGCGTCTGGCAACAGCTTTGCAGAAGCTGGAGGAAG
CTGAGAAGGCAGCAGATGAGAGTGAGAGAGGCATGAAAGTCATTGAGAGTCGAGCCCAAAAAGATGAAGAAAAAATGGAAATTCAGGAGA
TCCAACTGAAAGAGGCCAAGCACATTGCTGAAGATGCCGACCGCAAATATGAAGAGGTGGCCCGTAAGCTGGTCATCATTGAGAGCGACC
TGGAACGTGCAGAGGAGCGGGCTGAGCTCTCAGAAGGCCAAGTCCGACAGCTGGAAGAACAATTAAGAATAATGGATCAGACCTTGAAAG
CATTAATGGCTGCAGAGGATAAGTACTCGCAGAAGGAAGACAGATATGAGGAAGAGATCAAGGTCCTTTCCGACAAGCTGAAGGAGGCTG
AGACTCGGGCTGAGTTTGCGGAGAGGTCAGTAACTAAATTGGAGAAAAGCATTGATGACTTAGAAGACGAGCTGTACGCTCAGAAACTGA
AGTACAAAGCCATCAGCGAGGAGCTGGACCACGCTCTCAACGATATGACTTCCATGTAAACGTTCATCCACTCTGCCTGCTTACACCCTG
CCCTCATGCTAATATAAGTTTCTTTGCTTCACTTCTCCCAAGACTCCCTCGTCGAGCTGGATGTCCCACCTCTCTGAGCTCTGCATTTGT
CTATTCTCCAGCTGACCCTGGTTCTCTCTCTTAGCATCCTGCCTTAGAGCCAGGCACACACTGTGCTTTCTATTGTACAGAAGCTCTTCG

>61021_61021_1_NUP205-TPM1_NUP205_chr7_135269755_ENST00000285968_TPM1_chr15_63349184_ENST00000288398_length(amino acids)=610AA_BP=406
MATPLAVNSAASLWGPYKDIWHKVGNALWRRQPEAVHLLDKILKKHKPDFISLFKNPPKNVQQHEKVQKASTEGVAIQGQQGTRLLPEQL
IKEAFILSDLFDIGELAAVELLLAGEHQQPHFPGLTRGLVAVLLYWDGKRCIANSLKALIQSRRGKTWTLELSPELASMTTRFTDELMEQ
GLTYKVLTLVSQIDVNNEFEKLQRERGLGSEKHRKEVSDLIKECRQSLAESLFAWACQSPLGKEDTLLLIGHLERVTVEANGSLDAVNLA
LLMALLYCFDISFIEQSTEERDDMIHQLPLLTEKQYIATIHSRLQDSQLWKLPGLQATVRLAWALALRGISQLPDVTALAEFTEADEAMA
ELAIADNVFLFLMESVVVSEYFYQEEFYIRRVHNLITDFLALMPMKAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESE
RGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKY

--------------------------------------------------------------
>61021_61021_2_NUP205-TPM1_NUP205_chr7_135269755_ENST00000285968_TPM1_chr15_63349184_ENST00000358278_length(transcript)=2576nt_BP=1244nt
AAGGGCTCTGTTAGTGCGCCTCTAAGATGGCGACGCCTTTGGCGGTAAATTCGGCTGCTAGTCTATGGGGTCCTTACAAAGACATTTGGC
ATAAAGTGGGAAATGCTCTTTGGAGAAGACAACCTGAAGCTGTTCACCTTCTTGATAAGATTTTGAAGAAACACAAACCTGACTTCATCT
CATTGTTCAAAAATCCGCCAAAAAATGTTCAACAGCATGAGAAGGTTCAGAAAGCCAGTACAGAGGGAGTCGCCATTCAGGGTCAACAGG
GAACTCGACTTCTTCCTGAACAGCTCATTAAAGAAGCCTTTATTCTCAGTGACCTTTTTGATATTGGAGAATTGGCAGCTGTTGAGCTTC
TTCTTGCTGGAGAGCATCAACAGCCACATTTTCCTGGCCTTACCAGAGGATTAGTAGCTGTTCTTCTGTACTGGGATGGAAAGCGATGCA
TTGCGAATTCCTTGAAAGCCTTGATACAGTCTAGACGGGGAAAGACATGGACCCTAGAACTCAGTCCAGAGCTGGCTTCCATGACAACAC
GCTTTACAGATGAGCTGATGGAGCAAGGATTGACTTATAAAGTTCTTACGCTGGTGTCACAGATTGATGTGAATAATGAGTTTGAGAAAC
TACAGCGAGAGAGAGGTTTGGGCAGTGAAAAACATCGCAAAGAGGTTTCTGATCTCATTAAGGAGTGCAGGCAGTCTCTTGCAGAAAGCC
TTTTTGCCTGGGCTTGCCAGTCACCTTTAGGCAAAGAAGACACTCTCCTCCTCATTGGACATTTGGAAAGAGTGACAGTTGAGGCTAATG
GCTCACTGGATGCAGTGAATCTGGCTCTTCTTATGGCGCTTCTATACTGTTTTGATATCAGTTTTATAGAGCAAAGCACAGAGGAACGAG
ATGATATGATTCATCAACTTCCACTGTTGACAGAAAAACAGTACATTGCAACAATTCACTCTCGTCTTCAGGACTCACAGCTTTGGAAAC
TGCCTGGGCTCCAAGCCACTGTTAGACTTGCCTGGGCGCTGGCATTGAGGGGAATATCCCAGCTACCTGATGTGACAGCTCTGGCAGAAT
TCACAGAGGCAGATGAAGCAATGGCAGAACTCGCAATTGCTGACAACGTTTTCCTGTTCCTCATGGAATCTGTAGTGGTATCAGAATACT
TTTATCAGGAAGAATTTTATATTCGCAGAGTCCATAATCTCATCACAGATTTCCTTGCACTTATGCCAATGAAGGCTGAAGCCGACGTAG
CTTCTCTGAACAGACGCATCCAGCTGGTTGAGGAAGAGTTGGATCGTGCCCAGGAGCGTCTGGCAACAGCTTTGCAGAAGCTGGAGGAAG
CTGAGAAGGCAGCAGATGAGAGTGAGAGAGGCATGAAAGTCATTGAGAGTCGAGCCCAAAAAGATGAAGAAAAAATGGAAATTCAGGAGA
TCCAACTGAAAGAGGCCAAGCACATTGCTGAAGATGCCGACCGCAAATATGAAGAGGTGGCCCGTAAGCTGGTCATCATTGAGAGCGACC
TGGAACGTGCAGAGGAGCGGGCTGAGCTCTCAGAAGGCCAAGTCCGACAGCTGGAAGAACAATTAAGAATAATGGATCAGACCTTGAAAG
CATTAATGGCTGCAGAGGATAAGTACTCGCAGAAGGAAGACAGATATGAGGAAGAGATCAAGGTCCTTTCCGACAAGCTGAAGGAGGCTG
AGACTCGGGCTGAGTTTGCGGAGAGGTCAGTAACTAAATTGGAGAAAAGCATTGATGACTTAGAAGAGAAAGTGGCTCATGCCAAAGAAG
AAAACCTTAGTATGCATCAGATGCTGGATCAGACTTTACTGGAGTTAAACAACATGTGAAAACCTCCTTAGCTGCGACCACATTCTTTCG
TTTTGTTTTGTTTTGTTTTTAAACACCTGCTTACCCCTTAAATGCAATTTATTTACTTTTACCACTGTCACAGAAACATCCACAAGATAC
CAGCTAGGTCAGGGGGTGGGGAAAACACATACAAAAAGGCAAGCCCATGTCAGGGCGATCCTGGTTCAAATGTGCCATTTCCCGGGTTGA
TGCTGCCACACTTTGTAGAGAGTTTAGCAACACAGTGTGCTTAGTCAGCGTAGGAATCCTCACTAAAGCAGAAGAAGTTCCATTCAAAGT
GCCAATGATAGAGTCAACAGGAAGGTTAATGTTGGAAACACAATCAGGTGTGGATTGGTGCTACTTTGAACAAAAGGTCCCCCTGTGGTC
TTTTGTTCAACATTGTACAATGTAGAACTCTGTCCAACACTAATTTATTTTGTCTTGAGTTTTACTACAAGATGAGACTATGGATCCCGC
ATGCCTGAATTCACTAAAGCCAAGGGTCTGTAAGCCACGCTGCTCTTCCGAGACTTCCATTCCTTTCTGATTGGCACACGTGCAGCTCAT
GACAATCTGTAGGATAACAATCAGTGTGGATTTCCACTCTTTTCAGTCCTTCATGTTAAAGATTTAGACACCACATACAACTGGTAAAGG

>61021_61021_2_NUP205-TPM1_NUP205_chr7_135269755_ENST00000285968_TPM1_chr15_63349184_ENST00000358278_length(amino acids)=610AA_BP=406
MATPLAVNSAASLWGPYKDIWHKVGNALWRRQPEAVHLLDKILKKHKPDFISLFKNPPKNVQQHEKVQKASTEGVAIQGQQGTRLLPEQL
IKEAFILSDLFDIGELAAVELLLAGEHQQPHFPGLTRGLVAVLLYWDGKRCIANSLKALIQSRRGKTWTLELSPELASMTTRFTDELMEQ
GLTYKVLTLVSQIDVNNEFEKLQRERGLGSEKHRKEVSDLIKECRQSLAESLFAWACQSPLGKEDTLLLIGHLERVTVEANGSLDAVNLA
LLMALLYCFDISFIEQSTEERDDMIHQLPLLTEKQYIATIHSRLQDSQLWKLPGLQATVRLAWALALRGISQLPDVTALAEFTEADEAMA
ELAIADNVFLFLMESVVVSEYFYQEEFYIRRVHNLITDFLALMPMKAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESE
RGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKY

--------------------------------------------------------------
>61021_61021_3_NUP205-TPM1_NUP205_chr7_135269755_ENST00000440390_TPM1_chr15_63349184_ENST00000288398_length(transcript)=2060nt_BP=1203nt
AGTGCGCCTCTAAGATGGCGACGCCTTTGGCGGTAAATTCGGCTGCTAGTCTATGGGGTCCTTACAAAGACATTTGGCATAAAGTGGGAA
ATGCTCTTTGGAGAAGACAACCTGAAGCTGTTCACCTTCTTGATAAGATTTTGAAGAAACACAAACCTGACTTCATCTCATTGTTCAAAA
ATCCGCCAAAAAATGTTCAACAGCATGAGAAGGTTCAGAAAGCCAGTACAGAGGGAGTCGCCATTCAGGGTCAACAGGGAACTCGACTTC
TTCCTGAACAGCTCATTAAAGAAGCCTTTATTCTCAGTGACCTTTTTGATATTGGAGAATTGGCAGCTGTTGAGCTTCTTCTTGCTGGAG
AGCATCAACAGCCACATTTTCCTGGCCTTACCAGAGGATTAGTAGCTGTTCTTCTGTACTGGGATGGAAAGCGATGCATTGCGAATTCCT
TGAAAGCCTTGATACAGTCTAGACGGGGAAAGACATGGACCCTAGAACTCAGTCCAGAGCTGGCTTCCATGACAACACGCTTTACAGATG
AGCTGATGGAGCAAGGATTGACTTATAAAGTTCTTACGCTGGTGTCACAGATTGATGTGAATAATGAGTTTGAGAAACTACAGCGAGAGA
GAGGTTTCTGATCTCATTAAGGAGTGCAGGCAGTCTCTTGCAGAAAGCCTTTTTGCCTGGGCTTGCCAGTCACCTTTAGGCAAAGAAGAC
ACTCTCCTCCTCATTGGACATTTGGAAAGAGTGACAGTTGAGGCTAATGGCTCACTGGATGCAGTGAATCTGGCTCTTCTTATGGCGCTT
CTATACTGTTTTGATATCAGTTTTATAGAGCAAAGCACAGAGGAACGAGATGATATGATTCATCAACTTCCACTGTTGACAGAAAAACAG
TACATTGCAACAATTCACTCTCGTCTTCAGGACTCACAGCTTTGGAAACTGCCTGGGCTCCAAGCCACTGTTAGACTTGCCTGGGCGCTG
GCATTGAGGGGAATATCCCAGCTACCTGATGTGACAGCTCTGGCAGAATTCACAGAGGCAGATGAAGCAATGGCAGAACTCGCAATTGCT
GACAACGTTTTCCTGTTCCTCATGGAATCTGTAGTGGTATCAGAATACTTTTATCAGGAAGAATTTTATATTCGCAGAGTCCATAATCTC
ATCACAGATTTCCTTGCACTTATGCCAATGAAGGCTGAAGCCGACGTAGCTTCTCTGAACAGACGCATCCAGCTGGTTGAGGAAGAGTTG
GATCGTGCCCAGGAGCGTCTGGCAACAGCTTTGCAGAAGCTGGAGGAAGCTGAGAAGGCAGCAGATGAGAGTGAGAGAGGCATGAAAGTC
ATTGAGAGTCGAGCCCAAAAAGATGAAGAAAAAATGGAAATTCAGGAGATCCAACTGAAAGAGGCCAAGCACATTGCTGAAGATGCCGAC
CGCAAATATGAAGAGGTGGCCCGTAAGCTGGTCATCATTGAGAGCGACCTGGAACGTGCAGAGGAGCGGGCTGAGCTCTCAGAAGGCCAA
GTCCGACAGCTGGAAGAACAATTAAGAATAATGGATCAGACCTTGAAAGCATTAATGGCTGCAGAGGATAAGTACTCGCAGAAGGAAGAC
AGATATGAGGAAGAGATCAAGGTCCTTTCCGACAAGCTGAAGGAGGCTGAGACTCGGGCTGAGTTTGCGGAGAGGTCAGTAACTAAATTG
GAGAAAAGCATTGATGACTTAGAAGACGAGCTGTACGCTCAGAAACTGAAGTACAAAGCCATCAGCGAGGAGCTGGACCACGCTCTCAAC
GATATGACTTCCATGTAAACGTTCATCCACTCTGCCTGCTTACACCCTGCCCTCATGCTAATATAAGTTTCTTTGCTTCACTTCTCCCAA
GACTCCCTCGTCGAGCTGGATGTCCCACCTCTCTGAGCTCTGCATTTGTCTATTCTCCAGCTGACCCTGGTTCTCTCTCTTAGCATCCTG

>61021_61021_3_NUP205-TPM1_NUP205_chr7_135269755_ENST00000440390_TPM1_chr15_63349184_ENST00000288398_length(amino acids)=404AA_BP=200
MSLRNYSEREVSDLIKECRQSLAESLFAWACQSPLGKEDTLLLIGHLERVTVEANGSLDAVNLALLMALLYCFDISFIEQSTEERDDMIH
QLPLLTEKQYIATIHSRLQDSQLWKLPGLQATVRLAWALALRGISQLPDVTALAEFTEADEAMAELAIADNVFLFLMESVVVSEYFYQEE
FYIRRVHNLITDFLALMPMKAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKE
AKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLSDKLKEAETRAE

--------------------------------------------------------------
>61021_61021_4_NUP205-TPM1_NUP205_chr7_135269755_ENST00000440390_TPM1_chr15_63349184_ENST00000358278_length(transcript)=2535nt_BP=1203nt
AGTGCGCCTCTAAGATGGCGACGCCTTTGGCGGTAAATTCGGCTGCTAGTCTATGGGGTCCTTACAAAGACATTTGGCATAAAGTGGGAA
ATGCTCTTTGGAGAAGACAACCTGAAGCTGTTCACCTTCTTGATAAGATTTTGAAGAAACACAAACCTGACTTCATCTCATTGTTCAAAA
ATCCGCCAAAAAATGTTCAACAGCATGAGAAGGTTCAGAAAGCCAGTACAGAGGGAGTCGCCATTCAGGGTCAACAGGGAACTCGACTTC
TTCCTGAACAGCTCATTAAAGAAGCCTTTATTCTCAGTGACCTTTTTGATATTGGAGAATTGGCAGCTGTTGAGCTTCTTCTTGCTGGAG
AGCATCAACAGCCACATTTTCCTGGCCTTACCAGAGGATTAGTAGCTGTTCTTCTGTACTGGGATGGAAAGCGATGCATTGCGAATTCCT
TGAAAGCCTTGATACAGTCTAGACGGGGAAAGACATGGACCCTAGAACTCAGTCCAGAGCTGGCTTCCATGACAACACGCTTTACAGATG
AGCTGATGGAGCAAGGATTGACTTATAAAGTTCTTACGCTGGTGTCACAGATTGATGTGAATAATGAGTTTGAGAAACTACAGCGAGAGA
GAGGTTTCTGATCTCATTAAGGAGTGCAGGCAGTCTCTTGCAGAAAGCCTTTTTGCCTGGGCTTGCCAGTCACCTTTAGGCAAAGAAGAC
ACTCTCCTCCTCATTGGACATTTGGAAAGAGTGACAGTTGAGGCTAATGGCTCACTGGATGCAGTGAATCTGGCTCTTCTTATGGCGCTT
CTATACTGTTTTGATATCAGTTTTATAGAGCAAAGCACAGAGGAACGAGATGATATGATTCATCAACTTCCACTGTTGACAGAAAAACAG
TACATTGCAACAATTCACTCTCGTCTTCAGGACTCACAGCTTTGGAAACTGCCTGGGCTCCAAGCCACTGTTAGACTTGCCTGGGCGCTG
GCATTGAGGGGAATATCCCAGCTACCTGATGTGACAGCTCTGGCAGAATTCACAGAGGCAGATGAAGCAATGGCAGAACTCGCAATTGCT
GACAACGTTTTCCTGTTCCTCATGGAATCTGTAGTGGTATCAGAATACTTTTATCAGGAAGAATTTTATATTCGCAGAGTCCATAATCTC
ATCACAGATTTCCTTGCACTTATGCCAATGAAGGCTGAAGCCGACGTAGCTTCTCTGAACAGACGCATCCAGCTGGTTGAGGAAGAGTTG
GATCGTGCCCAGGAGCGTCTGGCAACAGCTTTGCAGAAGCTGGAGGAAGCTGAGAAGGCAGCAGATGAGAGTGAGAGAGGCATGAAAGTC
ATTGAGAGTCGAGCCCAAAAAGATGAAGAAAAAATGGAAATTCAGGAGATCCAACTGAAAGAGGCCAAGCACATTGCTGAAGATGCCGAC
CGCAAATATGAAGAGGTGGCCCGTAAGCTGGTCATCATTGAGAGCGACCTGGAACGTGCAGAGGAGCGGGCTGAGCTCTCAGAAGGCCAA
GTCCGACAGCTGGAAGAACAATTAAGAATAATGGATCAGACCTTGAAAGCATTAATGGCTGCAGAGGATAAGTACTCGCAGAAGGAAGAC
AGATATGAGGAAGAGATCAAGGTCCTTTCCGACAAGCTGAAGGAGGCTGAGACTCGGGCTGAGTTTGCGGAGAGGTCAGTAACTAAATTG
GAGAAAAGCATTGATGACTTAGAAGAGAAAGTGGCTCATGCCAAAGAAGAAAACCTTAGTATGCATCAGATGCTGGATCAGACTTTACTG
GAGTTAAACAACATGTGAAAACCTCCTTAGCTGCGACCACATTCTTTCGTTTTGTTTTGTTTTGTTTTTAAACACCTGCTTACCCCTTAA
ATGCAATTTATTTACTTTTACCACTGTCACAGAAACATCCACAAGATACCAGCTAGGTCAGGGGGTGGGGAAAACACATACAAAAAGGCA
AGCCCATGTCAGGGCGATCCTGGTTCAAATGTGCCATTTCCCGGGTTGATGCTGCCACACTTTGTAGAGAGTTTAGCAACACAGTGTGCT
TAGTCAGCGTAGGAATCCTCACTAAAGCAGAAGAAGTTCCATTCAAAGTGCCAATGATAGAGTCAACAGGAAGGTTAATGTTGGAAACAC
AATCAGGTGTGGATTGGTGCTACTTTGAACAAAAGGTCCCCCTGTGGTCTTTTGTTCAACATTGTACAATGTAGAACTCTGTCCAACACT
AATTTATTTTGTCTTGAGTTTTACTACAAGATGAGACTATGGATCCCGCATGCCTGAATTCACTAAAGCCAAGGGTCTGTAAGCCACGCT
GCTCTTCCGAGACTTCCATTCCTTTCTGATTGGCACACGTGCAGCTCATGACAATCTGTAGGATAACAATCAGTGTGGATTTCCACTCTT
TTCAGTCCTTCATGTTAAAGATTTAGACACCACATACAACTGGTAAAGGACGTTTTCTTGAGAGTTTTAACTATATGTAAACATTGTATA

>61021_61021_4_NUP205-TPM1_NUP205_chr7_135269755_ENST00000440390_TPM1_chr15_63349184_ENST00000358278_length(amino acids)=404AA_BP=200
MSLRNYSEREVSDLIKECRQSLAESLFAWACQSPLGKEDTLLLIGHLERVTVEANGSLDAVNLALLMALLYCFDISFIEQSTEERDDMIH
QLPLLTEKQYIATIHSRLQDSQLWKLPGLQATVRLAWALALRGISQLPDVTALAEFTEADEAMAELAIADNVFLFLMESVVVSEYFYQEE
FYIRRVHNLITDFLALMPMKAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKE
AKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLSDKLKEAETRAE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NUP205-TPM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for NUP205-TPM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for NUP205-TPM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource