Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NUPL2-YBX1 (FusionGDB2 ID:61158)

Fusion Gene Summary for NUPL2-YBX1

Fusion gene summary

Fusion gene information	Fusion gene name: NUPL2-YBX1
	Fusion gene ID: 61158
		Hgene	Tgene
	Gene symbol	NUPL2	YBX1
	Gene ID	11097	4904
	Gene name	nucleoporin 42	Y-box binding protein 1
	Synonyms	CG1\|NLP-1\|NLP_1\|NUPL2\|hCG1	BP-8\|CBF-A\|CSDA2\|CSDB\|DBPB\|EFI-A\|MDR-NF1\|NSEP-1\|NSEP1\|YB-1\|YB1
	Cytomap	7p15.3	1p34.2
	Type of gene	protein-coding	protein-coding
	Description	nucleoporin NUP42H_RG271G13.9NUP42 homolognucleoporin hCG1nucleoporin like 2nucleoporin-like protein 1nucleoporin-like protein 2	Y-box-binding protein 1CCAAT-binding transcription factor I subunit ADNA-binding protein BY-box transcription factorenhancer factor I subunit Amajor histocompatibility complex, class II, Y box-binding protein Inuclease-sensitive element-binding prot
	Modification date	20200313	20200327
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000487595, ENST00000258742, ENST00000410002,	ENST00000321358, ENST00000467957,
Fusion gene scores	* DoF score	10 X 3 X 7=210	8 X 7 X 6=336
	# samples	11	8
	** MAII score	log2(11/210*10)=-0.932885804141463 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NUPL2 [Title/Abstract] AND YBX1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NUPL2(23226765)-YBX1(43149073), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	YBX1	GO:0006355	regulation of transcription, DNA-templated	18809583
Tgene	YBX1	GO:0045944	positive regulation of transcription by RNA polymerase II	18809583
Tgene	YBX1	GO:0048255	mRNA stabilization	31358969
Tgene	YBX1	GO:1990428	miRNA transport	27559612

Fusion gene breakpoints across NUPL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across YBX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	READ	TCGA-DC-6157	NUPL2	chr7	23226765	+	YBX1	chr1	43149073	+

Top

Fusion Gene ORF analysis for NUPL2-YBX1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000487595	ENST00000321358	NUPL2	chr7	23226765	+	YBX1	chr1	43149073	+
3UTR-3UTR	ENST00000487595	ENST00000467957	NUPL2	chr7	23226765	+	YBX1	chr1	43149073	+
5CDS-3UTR	ENST00000258742	ENST00000467957	NUPL2	chr7	23226765	+	YBX1	chr1	43149073	+
5CDS-3UTR	ENST00000410002	ENST00000467957	NUPL2	chr7	23226765	+	YBX1	chr1	43149073	+
In-frame	ENST00000258742	ENST00000321358	NUPL2	chr7	23226765	+	YBX1	chr1	43149073	+
In-frame	ENST00000410002	ENST00000321358	NUPL2	chr7	23226765	+	YBX1	chr1	43149073	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000258742

NUPL2

chr7

23226765

ENST00000321358

YBX1

chr1

43149073

1913

704

226

1512

428

ENST00000410002

NUPL2

chr7

23226765

ENST00000321358

YBX1

chr1

43149073

1702

493

1301

428

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000258742	ENST00000321358	NUPL2	chr7	23226765	+	YBX1	chr1	43149073	+	0.000776989	0.999223
ENST00000410002	ENST00000321358	NUPL2	chr7	23226765	+	YBX1	chr1	43149073	+	0.000673008	0.99932706

Top

Fusion Genomic Features for NUPL2-YBX1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
NUPL2	chr7	23226765	+	YBX1	chr1	43149073	+	0.99833065	0.001669389
NUPL2	chr7	23226765	+	YBX1	chr1	43149073	+	0.99833065	0.001669389

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for NUPL2-YBX1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:23226765/chr1:43149073)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NUPL2

chr7:23226765

chr1:43149073

ENST00000258742

14_15

148

424.0

Repeat

Note=FG 1

Hgene

NUPL2

chr7:23226765

chr1:43149073

ENST00000258742

95_96

148

424.0

Repeat

Note=FG 2

Hgene

NUPL2

chr7:23226765

chr1:43149073

ENST00000258742

1_25

148

424.0

Zinc finger

C3H1-type

Tgene

YBX1

chr7:23226765

chr1:43149073

ENST00000321358

61_125

346.3333333333333

Domain

Note=CSD

Tgene

YBX1

chr7:23226765

chr1:43149073

ENST00000321358

65_70

346.3333333333333

Region

C5-methylcytosine binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NUPL2

chr7:23226765

chr1:43149073

ENST00000258742

238_378

148

424.0

Compositional bias

Note=Ser-rich

Hgene

NUPL2

chr7:23226765

chr1:43149073

ENST00000258742

218_219

148

424.0

Repeat

Note=FG 3

Hgene

NUPL2

chr7:23226765

chr1:43149073

ENST00000258742

220_221

148

424.0

Repeat

Note=FG 4

Hgene

NUPL2

chr7:23226765

chr1:43149073

ENST00000258742

265_266

148

424.0

Repeat

Note=FG 5

Hgene

NUPL2

chr7:23226765

chr1:43149073

ENST00000258742

271_272

148

424.0

Repeat

Note=FG 6

Hgene

NUPL2

chr7:23226765

chr1:43149073

ENST00000258742

288_289

148

424.0

Repeat

Note=FG 7

Hgene

NUPL2

chr7:23226765

chr1:43149073

ENST00000258742

290_291

148

424.0

Repeat

Note=FG 8

Hgene

NUPL2

chr7:23226765

chr1:43149073

ENST00000258742

311_312

148

424.0

Repeat

Note=FG 9

Hgene

NUPL2

chr7:23226765

chr1:43149073

ENST00000258742

336_337

148

424.0

Repeat

Note=FG 10

Hgene

NUPL2

chr7:23226765

chr1:43149073

ENST00000258742

345_346

148

424.0

Repeat

Note=FG 11

Hgene

NUPL2

chr7:23226765

chr1:43149073

ENST00000258742

364_365

148

424.0

Repeat

Note=FG 12

Top

Fusion Gene Sequence for NUPL2-YBX1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>61158_61158_1_NUPL2-YBX1_NUPL2_chr7_23226765_ENST00000258742_YBX1_chr1_43149073_ENST00000321358_length(transcript)=1913nt_BP=704nt
ACGTAACCGTTCAAGCATCCCTCCTTCCCAGGACACACTCAAAGCGTCAGAGCGGTCCGCTCTTCTCAAGTCCTATTGGCTCAAGTCCAT
GCGTCTCATGGCACTGCCGGGTGAGAGGCGGAAAAAGGCCTTCCCAGGCGCGAGAAGATGACGTCACAGTAGCCCGGCCGGGCGCCGAGG
TTGCCTTAGGGCTCTCTGCCCAGTAACAGGCATCGAACGGTGCAGACTGAAGACGCCCTCCGTCAGCGACGCCGTCGCAATGGCCATTTG
TCAATTCTTCCTTCAAGGCCGGTGCCGCTTTGGAGATCGGTGCTGGAACGAACATCCCGGTGCTAGGGGTGCAGGAGGAGGACGGCAGCA
ACCGCAGCAGCAGCCTTCAGGTAATAATAGACGTGGATGGAATACAACTAGCCAGAGATATTCCAATGTCATCCAGCCATCCAGTTTCTC
CAAATCCACACCATGGGGGGGCAGCAGAGATCAAGAAAAGCCATATTTCAGTTCTTTTGATTCTGGAGCTTCAACTAACAGGAAGGAAGG
CTTTGGATTGTCTGAGAACCCATTTGCTTCACTTAGTCCTGATGAGCAGAAAGATGAAAAGAAACTTCTGGAAGGAATTGTAAAAGATAT
GGAGGTTTGGGAATCATCAGGGCAGTGGATGTTTTCTGTTTATTCACCAGTGAAAAAGAAACCTAATATTTCAGCAACGAAGGTTTTGGG
AACAGTAAAATGGTTCAATGTAAGGAACGGATATGGTTTCATCAACAGGAATGACACCAAGGAAGATGTATTTGTACACCAGACTGCCAT
AAAGAAGAATAACCCCAGGAAGTACCTTCGCAGTGTAGGAGATGGAGAGACTGTGGAGTTTGATGTTGTTGAAGGAGAAAAGGGTGCGGA
GGCAGCAAATGTTACAGGTCCTGGTGGTGTTCCAGTTCAAGGCAGTAAATATGCAGCAGACCGTAACCATTATAGACGCTATCCACGTCG
TAGGGGTCCTCCACGCAATTACCAGCAAAATTACCAGAATAGTGAGAGTGGGGAAAAGAACGAGGGATCGGAGAGTGCTCCCGAAGGCCA
GGCCCAACAACGCCGGCCCTACCGCAGGCGAAGGTTCCCACCTTACTACATGCGGAGACCCTATGGGCGTCGACCACAGTATTCCAACCC
TCCTGTGCAGGGAGAAGTGATGGAGGGTGCTGACAACCAGGGTGCAGGAGAACAAGGTAGACCAGTGAGGCAGAATATGTATCGGGGATA
TAGACCACGATTCCGCAGGGGCCCTCCTCGCCAAAGACAGCCTAGAGAGGACGGCAATGAAGAAGATAAAGAAAATCAAGGAGATGAGAC
CCAAGGTCAGCAGCCACCTCAACGTCGGTACCGCCGCAACTTCAATTACCGACGCAGACGCCCAGAAAACCCTAAACCACAAGATGGCAA
AGAGACAAAAGCAGCCGATCCACCAGCTGAGAATTCGTCCGCTCCCGAGGCTGAGCAGGGCGGGGCTGAGTAAATGCCGGCTTACCATCT
CTACCATCATCCGGTTTAGTCATCCAACAAGAAGAAATATGAAATTCCAGCAATAAGAAATGAACAAAAGATTGGAGCTGAAGACCTAAA
GTGCTTGCTTTTTGCCCGTTGACCAGATAAATAGAACTATCTGCATTATCTATGCAGCATGGGGTTTTTATTATTTTTACCTAAAGACGT
CTCTTTTTGGTAATAACAAACGTGTTTTTTAAAAAAGCCTGGTTTTTCTCAATACGCCTTTAAAGGTTTTTAAATTGTTTCATATCTGGT
CAAGTTGAGATTTTTAAGAACTTCATTTTTAATTTGTAATAAAAGTTTACAACTTGATTTTTTCAAAAAAGTCAACAAACTGCAAGCACC

>61158_61158_1_NUPL2-YBX1_NUPL2_chr7_23226765_ENST00000258742_YBX1_chr1_43149073_ENST00000321358_length(amino acids)=428AA_BP=159
MKTPSVSDAVAMAICQFFLQGRCRFGDRCWNEHPGARGAGGGRQQPQQQPSGNNRRGWNTTSQRYSNVIQPSSFSKSTPWGGSRDQEKPY
FSSFDSGASTNRKEGFGLSENPFASLSPDEQKDEKKLLEGIVKDMEVWESSGQWMFSVYSPVKKKPNISATKVLGTVKWFNVRNGYGFIN
RNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNHYRRYPRRRGPPRNYQQNYQNSE
SGEKNEGSESAPEGQAQQRRPYRRRRFPPYYMRRPYGRRPQYSNPPVQGEVMEGADNQGAGEQGRPVRQNMYRGYRPRFRRGPPRQRQPR

--------------------------------------------------------------
>61158_61158_2_NUPL2-YBX1_NUPL2_chr7_23226765_ENST00000410002_YBX1_chr1_43149073_ENST00000321358_length(transcript)=1702nt_BP=493nt
ATCGAACGGTGCAGACTGAAGACGCCCTCCGTCAGCGACGCCGTCGCAATGGCCATTTGTCAATTCTTCCTTCAAGGCCGGTGCCGCTTT
GGAGATCGGTGCTGGAACGAACATCCCGGTGCTAGGGGTGCAGGAGGAGGACGGCAGCAACCGCAGCAGCAGCCTTCAGGTAATAATAGA
CGTGGATGGAATACAACTAGCCAGAGATATTCCAATGTCATCCAGCCATCCAGTTTCTCCAAATCCACACCATGGGGGGGCAGCAGAGAT
CAAGAAAAGCCATATTTCAGTTCTTTTGATTCTGGAGCTTCAACTAACAGGAAGGAAGGCTTTGGATTGTCTGAGAACCCATTTGCTTCA
CTTAGTCCTGATGAGCAGAAAGATGAAAAGAAACTTCTGGAAGGAATTGTAAAAGATATGGAGGTTTGGGAATCATCAGGGCAGTGGATG
TTTTCTGTTTATTCACCAGTGAAAAAGAAACCTAATATTTCAGCAACGAAGGTTTTGGGAACAGTAAAATGGTTCAATGTAAGGAACGGA
TATGGTTTCATCAACAGGAATGACACCAAGGAAGATGTATTTGTACACCAGACTGCCATAAAGAAGAATAACCCCAGGAAGTACCTTCGC
AGTGTAGGAGATGGAGAGACTGTGGAGTTTGATGTTGTTGAAGGAGAAAAGGGTGCGGAGGCAGCAAATGTTACAGGTCCTGGTGGTGTT
CCAGTTCAAGGCAGTAAATATGCAGCAGACCGTAACCATTATAGACGCTATCCACGTCGTAGGGGTCCTCCACGCAATTACCAGCAAAAT
TACCAGAATAGTGAGAGTGGGGAAAAGAACGAGGGATCGGAGAGTGCTCCCGAAGGCCAGGCCCAACAACGCCGGCCCTACCGCAGGCGA
AGGTTCCCACCTTACTACATGCGGAGACCCTATGGGCGTCGACCACAGTATTCCAACCCTCCTGTGCAGGGAGAAGTGATGGAGGGTGCT
GACAACCAGGGTGCAGGAGAACAAGGTAGACCAGTGAGGCAGAATATGTATCGGGGATATAGACCACGATTCCGCAGGGGCCCTCCTCGC
CAAAGACAGCCTAGAGAGGACGGCAATGAAGAAGATAAAGAAAATCAAGGAGATGAGACCCAAGGTCAGCAGCCACCTCAACGTCGGTAC
CGCCGCAACTTCAATTACCGACGCAGACGCCCAGAAAACCCTAAACCACAAGATGGCAAAGAGACAAAAGCAGCCGATCCACCAGCTGAG
AATTCGTCCGCTCCCGAGGCTGAGCAGGGCGGGGCTGAGTAAATGCCGGCTTACCATCTCTACCATCATCCGGTTTAGTCATCCAACAAG
AAGAAATATGAAATTCCAGCAATAAGAAATGAACAAAAGATTGGAGCTGAAGACCTAAAGTGCTTGCTTTTTGCCCGTTGACCAGATAAA
TAGAACTATCTGCATTATCTATGCAGCATGGGGTTTTTATTATTTTTACCTAAAGACGTCTCTTTTTGGTAATAACAAACGTGTTTTTTA
AAAAAGCCTGGTTTTTCTCAATACGCCTTTAAAGGTTTTTAAATTGTTTCATATCTGGTCAAGTTGAGATTTTTAAGAACTTCATTTTTA

>61158_61158_2_NUPL2-YBX1_NUPL2_chr7_23226765_ENST00000410002_YBX1_chr1_43149073_ENST00000321358_length(amino acids)=428AA_BP=159
MKTPSVSDAVAMAICQFFLQGRCRFGDRCWNEHPGARGAGGGRQQPQQQPSGNNRRGWNTTSQRYSNVIQPSSFSKSTPWGGSRDQEKPY
FSSFDSGASTNRKEGFGLSENPFASLSPDEQKDEKKLLEGIVKDMEVWESSGQWMFSVYSPVKKKPNISATKVLGTVKWFNVRNGYGFIN
RNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNHYRRYPRRRGPPRNYQQNYQNSE
SGEKNEGSESAPEGQAQQRRPYRRRRFPPYYMRRPYGRRPQYSNPPVQGEVMEGADNQGAGEQGRPVRQNMYRGYRPRFRRGPPRQRQPR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NUPL2-YBX1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	NUPL2	chr7:23226765	chr1:43149073	ENST00000258742	+	3	7	365_423	148.33333333333334	424.0	GLE1
Hgene	NUPL2	chr7:23226765	chr1:43149073	ENST00000258742	+	3	7	94_170	148.33333333333334	424.0	HIV-1 Vpr
Tgene	YBX1	chr7:23226765	chr1:43149073	ENST00000321358		0	8	15_71	55.333333333333336	346.3333333333333	ss-DNA

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for NUPL2-YBX1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for NUPL2-YBX1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source