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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ARHGAP42-SBF2 (FusionGDB2 ID:6116)

Fusion Gene Summary for ARHGAP42-SBF2

Fusion gene summary

Fusion gene information	Fusion gene name: ARHGAP42-SBF2
	Fusion gene ID: 6116
		Hgene	Tgene
	Gene symbol	ARHGAP42	SBF2
	Gene ID	143872	81846
	Gene name	Rho GTPase activating protein 42	SET binding factor 2
	Synonyms	AD031\|GRAF3\|TMEM133	CMT4B2\|DENND7B\|MTMR13
	Cytomap	11q22.1	11p15.4
	Type of gene	protein-coding	protein-coding
	Description	rho GTPase-activating protein 42rho-type GTPase-activating protein 42transmembrane protein 133	myotubularin-related protein 13DENN/MADD domain containing 7Binactive phosphatidylinositol 3-phosphatase 13
	Modification date	20200313	20200328
	UniProtAcc	A6NI28	.
	Ensembl transtripts involved in fusion gene	ENST00000298815, ENST00000524892, ENST00000534060,	ENST00000527019, ENST00000256190,
Fusion gene scores	* DoF score	11 X 7 X 7=539	21 X 19 X 5=1995
	# samples	12	23
	** MAII score	log2(12/539*10)=-2.16725086714399 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(23/1995*10)=-3.11668298016533 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ARHGAP42 [Title/Abstract] AND SBF2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ARHGAP42(100558563)-SBF2(9812230), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ARHGAP42	GO:0090630	activation of GTPase activity	24335996

Fusion gene breakpoints across ARHGAP42 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SBF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-94-8491-01A	ARHGAP42	chr11	100558563	-	SBF2	chr11	9812230	-
ChimerDB4	LUSC	TCGA-94-8491-01A	ARHGAP42	chr11	100558563	+	SBF2	chr11	9812230	-
ChimerDB4	LUSC	TCGA-94-8491	ARHGAP42	chr11	100558563	+	SBF2	chr11	9812230	-

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Fusion Gene ORF analysis for ARHGAP42-SBF2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000298815	ENST00000527019	ARHGAP42	chr11	100558563	+	SBF2	chr11	9812230	-
5CDS-intron	ENST00000524892	ENST00000527019	ARHGAP42	chr11	100558563	+	SBF2	chr11	9812230	-
In-frame	ENST00000298815	ENST00000256190	ARHGAP42	chr11	100558563	+	SBF2	chr11	9812230	-
In-frame	ENST00000524892	ENST00000256190	ARHGAP42	chr11	100558563	+	SBF2	chr11	9812230	-
intron-3CDS	ENST00000534060	ENST00000256190	ARHGAP42	chr11	100558563	+	SBF2	chr11	9812230	-
intron-intron	ENST00000534060	ENST00000527019	ARHGAP42	chr11	100558563	+	SBF2	chr11	9812230	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000524892

ARHGAP42

chr11

100558563

ENST00000256190

SBF2

chr11

9812230

2911

180

1159

377

ENST00000298815

ARHGAP42

chr11

100558563

ENST00000256190

SBF2

chr11

9812230

2888

157

1136

377

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000524892	ENST00000256190	ARHGAP42	chr11	100558563	+	SBF2	chr11	9812230	-	0.002194662	0.9978053
ENST00000298815	ENST00000256190	ARHGAP42	chr11	100558563	+	SBF2	chr11	9812230	-	0.002109606	0.9978904

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Fusion Genomic Features for ARHGAP42-SBF2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARHGAP42-SBF2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:100558563/chr11:9812230)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ARHGAP42 A6NI28	.
FUNCTION: May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle. {ECO:0000269\|PubMed:24335996}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SBF2

chr11:100558563

chr11:9812230

ENST00000256190

1743_1847

1523

1850.0

Domain

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ARHGAP42

chr11:100558563

chr11:9812230

ENST00000298815

225_261

875.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ARHGAP42

chr11:100558563

chr11:9812230

ENST00000298815

619_762

875.0

Compositional bias

Note=Ser-rich

Hgene

ARHGAP42

chr11:100558563

chr11:9812230

ENST00000298815

265_374

875.0

Domain

Hgene

ARHGAP42

chr11:100558563

chr11:9812230

ENST00000298815

376_572

875.0

Domain

Rho-GAP

Hgene

ARHGAP42

chr11:100558563

chr11:9812230

ENST00000298815

7_262

875.0

Domain

Note=BAR

Hgene

ARHGAP42

chr11:100558563

chr11:9812230

ENST00000298815

816_874

875.0

Domain

SH3

Tgene

SBF2

chr11:100558563

chr11:9812230

ENST00000256190

1108_1584

1523

1850.0

Domain

Myotubularin phosphatase

Tgene

SBF2

chr11:100558563

chr11:9812230

ENST00000256190

191_324

1523

1850.0

Domain

cDENN

Tgene

SBF2

chr11:100558563

chr11:9812230

ENST00000256190

326_427

1523

1850.0

Domain

dDENN

Tgene

SBF2

chr11:100558563

chr11:9812230

ENST00000256190

7_172

1523

1850.0

Domain

uDENN

Tgene

SBF2

chr11:100558563

chr11:9812230

ENST00000256190

871_957

1523

1850.0

Domain

GRAM

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Fusion Gene Sequence for ARHGAP42-SBF2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>6116_6116_1_ARHGAP42-SBF2_ARHGAP42_chr11_100558563_ENST00000298815_SBF2_chr11_9812230_ENST00000256190_length(transcript)=2888nt_BP=157nt
GCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTG
GAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAGAACTTTATTTGATGATAAAGGA
GAAAAGCATGCCAAAAAAGGAGTCTGTATTTGGGAATGTATTGACAGAATGCACAAGAGGAGTCCCATTTTCTTTAATTATTTATATTCA
CCATTGGAAATAGAGGCTCTAAAGCCCAATGTAAACGTCTCTAGCCTCAAGAAGTGGGATTACTACATAGAAGAGACCCTGTCCACAGGC
CCTTCCTATGACTGGATGATGCTAACCCCCAAGCACTTCCCCTCCGAAGACTCTGACCTGGCTGGAGAAGCTGGGCCACGGAGCCAGAGG
AGAACAGTGTGGCCATGCTATGATGATGTCAGCTGTACTCAGCCTGATGCTCTCACCAGCCTTTTCAGTGAAATTGAAAAATTGGAGCAC
AAATTGAACCAAGCCCCTGAGAAGTGGCAGCAGCTGTGGGAAAGGGTAACCGTGGACCTTAAAGAAGAACCAAGAACAGATCGCTCCCAA
AGACACCTGTCGAGATCCCCAGGAATTGTGTCTACCAACCTACCTTCCTATCAGAAGAGGTCTCTGCTACATCTCCCAGACAGCAGCATG
GGGGAGGAACAGAATTCCAGCATCTCCCCATCCAATGGAGTGGAGCGAAGAGCAGCCACGCTCTATAGCCAGTATACATCCAAGAATGAT
GAAAACAGGTCCTTTGAGGGAACACTTTATAAAAGAGGGGCTTTGCTGAAAGGTTGGAAGCCCCGTTGGTTTGTTTTGGATGTAACAAAA
CATCAGCTGCGCTACTATGACTCAGGTGAGGACACAAGCTGTAAAGGCCACATTGATCTGGCTGAAGTAGAAATGGTCATCCCTGCTGGC
CCCAGCATGGGAGCCCCAAAGCACACAAGTGACAAGGCTTTCTTTGATCTCAAGACCAGCAAACGTGTGTATAACTTCTGCGCCCAGGAT
GGACAGAGTGCCCAGCAATGGATGGACAAGATCCAGAGTTGTATCTCTGATGCCTGATGCCCATGGTCAACCCACGCAGAAGAAACAGAA
GAACTCATGCTGCCAGATAGATAGAAAAAGAAGCATGGATCCTTGAGGAGCTGACAACAAGTTATCCCAGGGCCTGAGGTTCTCCTGCCC
AGTCCCCTCTTGCAGGGGTTGCTATATCTACTTAACCTGAATAGGTGTTTCACACAGGTCTGGTCAACAGCCCCATGCACTCCCTGTATC
TTGCACTAAATTTTTCTAACAGGGTCTTAGTGGTTAATGATCAGAAGATGTCTCCTGAGCCAACTGTGAACCTCACCCAGGCAAAATGGC
TACCACCTACTTGGGTCCTTCTTCATGAAAGCTATAGATCCTTTTTTGTTCTCTGAGGTCATAATTTCCTCGGAGACCTGTTTAACAAGC
AAAAATCAAAACCCTCCAAGATTGTCTCATATTCTACCTGGACTAGGTTTCCTATGAGAGACATCTACTTGTAATGCCTGACCTTTGAGA
TGCTCAGTTCTCTGGTGCTGCCAAAAGATGCTTCCATGGTCCGTGCTCTGCCAGTGGGGTTCACAACAAGAGACGTCATTGTTCAGTAGC
AGGCAAAGAGGGAGCACACAGCATTATTCTGATGGAAAAAGATTATCCAGGGAATGGTACAACAATGACCAGCCCAATGCAGGAAAACAC
TACTTCCAAAACACTGAATTCTCTAGACCAGAGGTGCTCTGAGGATCCAGGGCCTTGTGTTCTTATGTATCTTCTGCTTCCTGACAGCTT
CTTTTTCAAAATAACATGCAAAAAAAGCTGAATGCACTAACTCACAAAACAAACACTTGCACTGAATTCCCAATGAAGTGAAGATGTTGG
AAAGACAGAGGCCAGCTATTTAGGACCATACGCACCTGTGACAAGGGCTGTGTTGACCACAGTCACACTGTGGCATGACTGGATACCCAA
ACTACACTTCTACACATGAAAAGTAAGAACTGTCTTTAGATTTTCTTTACTTTGATAACTTGTGATTGTTTAGCTTAAGACCCAAGAAAT
GCTGTTTGCTCATGGTAAACAGAAACAGCATCTTCGCTACAACCACTGACACCAGCTGGCGTCATAGGTAGCTAGATCATTGCATTTGTT
TTGAAATGTTAATATGTTAAATACTAAACTAATATTTCAAAAATGTGTATATATGATTTCTATATCCTTGTTTTTCAGATAGCCTGCTTA
TAATTTAATATAAATTAACTGATGCATTCATAAGATTTCAATAATGAAATGGTTCCCTTTTAAAAAATAAAAATACTTTGTAGATTAAAA
ATAAATCAGAATTTCAAATTTAAAATTGTCCACACACTAGGAAATAGAACTGTGTTAATATATAAGAAATCTGGGGATAATTAAGAATGA
AGGACTTTTCTATCATTTCCATTTTATAAATTGCCACCTGTGAAAATGGTTTTTGCACATTATTTGTATTTTTCTTTGTATATGAAATAA
TTTTTTGTACTTTGTAAAATATGGAGCCCATTGTACCTTCAGCTATTTGAGACTATACACAGTGCTTCTTTTGTAACTGGATTACTTTAA
CTTTCGTGAAGGCATTACATTGCCTCACATTCACTAACCACCTTGAATTAAATTTATTTCTTAAGAAAAAGCATCCCTCATTTACTGTGA
ACTAAAGTTCATTCTGTAGTGCACAGCATTCAGGAGGGTAACACTCAGGATTCATACATGGGACTAAAGGTTCAAGAATAAAACAAAGCA

>6116_6116_1_ARHGAP42-SBF2_ARHGAP42_chr11_100558563_ENST00000298815_SBF2_chr11_9812230_ENST00000256190_length(amino acids)=377AA_BP=52
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRRTLFDDKGEKHAKKGVCIWECIDRMHKRSPIFFNYLYSP
LEIEALKPNVNVSSLKKWDYYIEETLSTGPSYDWMMLTPKHFPSEDSDLAGEAGPRSQRRTVWPCYDDVSCTQPDALTSLFSEIEKLEHK
LNQAPEKWQQLWERVTVDLKEEPRTDRSQRHLSRSPGIVSTNLPSYQKRSLLHLPDSSMGEEQNSSISPSNGVERRAATLYSQYTSKNDE
NRSFEGTLYKRGALLKGWKPRWFVLDVTKHQLRYYDSGEDTSCKGHIDLAEVEMVIPAGPSMGAPKHTSDKAFFDLKTSKRVYNFCAQDG

--------------------------------------------------------------
>6116_6116_2_ARHGAP42-SBF2_ARHGAP42_chr11_100558563_ENST00000524892_SBF2_chr11_9812230_ENST00000256190_length(transcript)=2911nt_BP=180nt
CGGCCGCCGCTGGCAGCGCCTGTGCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCT
TGCAGTGTCACGAGATTGAGCTGGAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGA
GAACTTTATTTGATGATAAAGGAGAAAAGCATGCCAAAAAAGGAGTCTGTATTTGGGAATGTATTGACAGAATGCACAAGAGGAGTCCCA
TTTTCTTTAATTATTTATATTCACCATTGGAAATAGAGGCTCTAAAGCCCAATGTAAACGTCTCTAGCCTCAAGAAGTGGGATTACTACA
TAGAAGAGACCCTGTCCACAGGCCCTTCCTATGACTGGATGATGCTAACCCCCAAGCACTTCCCCTCCGAAGACTCTGACCTGGCTGGAG
AAGCTGGGCCACGGAGCCAGAGGAGAACAGTGTGGCCATGCTATGATGATGTCAGCTGTACTCAGCCTGATGCTCTCACCAGCCTTTTCA
GTGAAATTGAAAAATTGGAGCACAAATTGAACCAAGCCCCTGAGAAGTGGCAGCAGCTGTGGGAAAGGGTAACCGTGGACCTTAAAGAAG
AACCAAGAACAGATCGCTCCCAAAGACACCTGTCGAGATCCCCAGGAATTGTGTCTACCAACCTACCTTCCTATCAGAAGAGGTCTCTGC
TACATCTCCCAGACAGCAGCATGGGGGAGGAACAGAATTCCAGCATCTCCCCATCCAATGGAGTGGAGCGAAGAGCAGCCACGCTCTATA
GCCAGTATACATCCAAGAATGATGAAAACAGGTCCTTTGAGGGAACACTTTATAAAAGAGGGGCTTTGCTGAAAGGTTGGAAGCCCCGTT
GGTTTGTTTTGGATGTAACAAAACATCAGCTGCGCTACTATGACTCAGGTGAGGACACAAGCTGTAAAGGCCACATTGATCTGGCTGAAG
TAGAAATGGTCATCCCTGCTGGCCCCAGCATGGGAGCCCCAAAGCACACAAGTGACAAGGCTTTCTTTGATCTCAAGACCAGCAAACGTG
TGTATAACTTCTGCGCCCAGGATGGACAGAGTGCCCAGCAATGGATGGACAAGATCCAGAGTTGTATCTCTGATGCCTGATGCCCATGGT
CAACCCACGCAGAAGAAACAGAAGAACTCATGCTGCCAGATAGATAGAAAAAGAAGCATGGATCCTTGAGGAGCTGACAACAAGTTATCC
CAGGGCCTGAGGTTCTCCTGCCCAGTCCCCTCTTGCAGGGGTTGCTATATCTACTTAACCTGAATAGGTGTTTCACACAGGTCTGGTCAA
CAGCCCCATGCACTCCCTGTATCTTGCACTAAATTTTTCTAACAGGGTCTTAGTGGTTAATGATCAGAAGATGTCTCCTGAGCCAACTGT
GAACCTCACCCAGGCAAAATGGCTACCACCTACTTGGGTCCTTCTTCATGAAAGCTATAGATCCTTTTTTGTTCTCTGAGGTCATAATTT
CCTCGGAGACCTGTTTAACAAGCAAAAATCAAAACCCTCCAAGATTGTCTCATATTCTACCTGGACTAGGTTTCCTATGAGAGACATCTA
CTTGTAATGCCTGACCTTTGAGATGCTCAGTTCTCTGGTGCTGCCAAAAGATGCTTCCATGGTCCGTGCTCTGCCAGTGGGGTTCACAAC
AAGAGACGTCATTGTTCAGTAGCAGGCAAAGAGGGAGCACACAGCATTATTCTGATGGAAAAAGATTATCCAGGGAATGGTACAACAATG
ACCAGCCCAATGCAGGAAAACACTACTTCCAAAACACTGAATTCTCTAGACCAGAGGTGCTCTGAGGATCCAGGGCCTTGTGTTCTTATG
TATCTTCTGCTTCCTGACAGCTTCTTTTTCAAAATAACATGCAAAAAAAGCTGAATGCACTAACTCACAAAACAAACACTTGCACTGAAT
TCCCAATGAAGTGAAGATGTTGGAAAGACAGAGGCCAGCTATTTAGGACCATACGCACCTGTGACAAGGGCTGTGTTGACCACAGTCACA
CTGTGGCATGACTGGATACCCAAACTACACTTCTACACATGAAAAGTAAGAACTGTCTTTAGATTTTCTTTACTTTGATAACTTGTGATT
GTTTAGCTTAAGACCCAAGAAATGCTGTTTGCTCATGGTAAACAGAAACAGCATCTTCGCTACAACCACTGACACCAGCTGGCGTCATAG
GTAGCTAGATCATTGCATTTGTTTTGAAATGTTAATATGTTAAATACTAAACTAATATTTCAAAAATGTGTATATATGATTTCTATATCC
TTGTTTTTCAGATAGCCTGCTTATAATTTAATATAAATTAACTGATGCATTCATAAGATTTCAATAATGAAATGGTTCCCTTTTAAAAAA
TAAAAATACTTTGTAGATTAAAAATAAATCAGAATTTCAAATTTAAAATTGTCCACACACTAGGAAATAGAACTGTGTTAATATATAAGA
AATCTGGGGATAATTAAGAATGAAGGACTTTTCTATCATTTCCATTTTATAAATTGCCACCTGTGAAAATGGTTTTTGCACATTATTTGT
ATTTTTCTTTGTATATGAAATAATTTTTTGTACTTTGTAAAATATGGAGCCCATTGTACCTTCAGCTATTTGAGACTATACACAGTGCTT
CTTTTGTAACTGGATTACTTTAACTTTCGTGAAGGCATTACATTGCCTCACATTCACTAACCACCTTGAATTAAATTTATTTCTTAAGAA
AAAGCATCCCTCATTTACTGTGAACTAAAGTTCATTCTGTAGTGCACAGCATTCAGGAGGGTAACACTCAGGATTCATACATGGGACTAA

>6116_6116_2_ARHGAP42-SBF2_ARHGAP42_chr11_100558563_ENST00000524892_SBF2_chr11_9812230_ENST00000256190_length(amino acids)=377AA_BP=52
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRRTLFDDKGEKHAKKGVCIWECIDRMHKRSPIFFNYLYSP
LEIEALKPNVNVSSLKKWDYYIEETLSTGPSYDWMMLTPKHFPSEDSDLAGEAGPRSQRRTVWPCYDDVSCTQPDALTSLFSEIEKLEHK
LNQAPEKWQQLWERVTVDLKEEPRTDRSQRHLSRSPGIVSTNLPSYQKRSLLHLPDSSMGEEQNSSISPSNGVERRAATLYSQYTSKNDE
NRSFEGTLYKRGALLKGWKPRWFVLDVTKHQLRYYDSGEDTSCKGHIDLAEVEMVIPAGPSMGAPKHTSDKAFFDLKTSKRVYNFCAQDG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARHGAP42-SBF2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ARHGAP42-SBF2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ARHGAP42-SBF2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source