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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:NXF1-KLK10 (FusionGDB2 ID:61203)

Fusion Gene Summary for NXF1-KLK10

Fusion gene summary

Fusion gene information	Fusion gene name: NXF1-KLK10
	Fusion gene ID: 61203
		Hgene	Tgene
	Gene symbol	NXF1	KLK10
	Gene ID	10482	5655
	Gene name	nuclear RNA export factor 1	kallikrein related peptidase 10
	Synonyms	MEX67\|TAP	NES1\|PRSSL1
	Cytomap	11q12.3	19q13.41
	Type of gene	protein-coding	protein-coding
	Description	nuclear RNA export factor 1mRNA export factor TAPtip associating proteintip-associated protein	kallikrein-10breast normal epithelial cell associated serine proteasekallikrein 10 protein 1kallikrein 10 protein 12kallikrein 10 protein 13kallikrein 10 protein 2kallikrein 10 protein 3kallikrein 10 protein 4kallikrein 10 protein 5kallikrein 10
	Modification date	20200313	20200313
	UniProtAcc	.	O43240
	Ensembl transtripts involved in fusion gene	ENST00000294172, ENST00000532297, ENST00000439713, ENST00000531131, ENST00000531709, ENST00000533048,	ENST00000309958, ENST00000358789, ENST00000391805,
Fusion gene scores	* DoF score	10 X 13 X 7=910	7 X 6 X 3=126
	# samples	12	8
	** MAII score	log2(12/910*10)=-2.92283213947754 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/126*10)=-0.655351828612554 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NXF1 [Title/Abstract] AND KLK10 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NXF1(62567848)-KLK10(51520546), # samples:1
Anticipated loss of major functional domain due to fusion event.	NXF1-KLK10 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. NXF1-KLK10 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NXF1	GO:0006406	mRNA export from nucleus	19165146\|28984244

Fusion gene breakpoints across NXF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KLK10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-24-1546	NXF1	chr11	62567848	-	KLK10	chr19	51520546	-

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Fusion Gene ORF analysis for NXF1-KLK10

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000294172	ENST00000309958	NXF1	chr11	62567848	-	KLK10	chr19	51520546	-
Frame-shift	ENST00000294172	ENST00000358789	NXF1	chr11	62567848	-	KLK10	chr19	51520546	-
Frame-shift	ENST00000294172	ENST00000391805	NXF1	chr11	62567848	-	KLK10	chr19	51520546	-
In-frame	ENST00000532297	ENST00000309958	NXF1	chr11	62567848	-	KLK10	chr19	51520546	-
In-frame	ENST00000532297	ENST00000358789	NXF1	chr11	62567848	-	KLK10	chr19	51520546	-
In-frame	ENST00000532297	ENST00000391805	NXF1	chr11	62567848	-	KLK10	chr19	51520546	-
intron-3CDS	ENST00000439713	ENST00000309958	NXF1	chr11	62567848	-	KLK10	chr19	51520546	-
intron-3CDS	ENST00000439713	ENST00000358789	NXF1	chr11	62567848	-	KLK10	chr19	51520546	-
intron-3CDS	ENST00000439713	ENST00000391805	NXF1	chr11	62567848	-	KLK10	chr19	51520546	-
intron-3CDS	ENST00000531131	ENST00000309958	NXF1	chr11	62567848	-	KLK10	chr19	51520546	-
intron-3CDS	ENST00000531131	ENST00000358789	NXF1	chr11	62567848	-	KLK10	chr19	51520546	-
intron-3CDS	ENST00000531131	ENST00000391805	NXF1	chr11	62567848	-	KLK10	chr19	51520546	-
intron-3CDS	ENST00000531709	ENST00000309958	NXF1	chr11	62567848	-	KLK10	chr19	51520546	-
intron-3CDS	ENST00000531709	ENST00000358789	NXF1	chr11	62567848	-	KLK10	chr19	51520546	-
intron-3CDS	ENST00000531709	ENST00000391805	NXF1	chr11	62567848	-	KLK10	chr19	51520546	-
intron-3CDS	ENST00000533048	ENST00000309958	NXF1	chr11	62567848	-	KLK10	chr19	51520546	-
intron-3CDS	ENST00000533048	ENST00000358789	NXF1	chr11	62567848	-	KLK10	chr19	51520546	-
intron-3CDS	ENST00000533048	ENST00000391805	NXF1	chr11	62567848	-	KLK10	chr19	51520546	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000532297	NXF1	chr11	62567848	-	ENST00000309958	KLK10	chr19	51520546	-	4450	1646	630	1853	407
ENST00000532297	NXF1	chr11	62567848	-	ENST00000391805	KLK10	chr19	51520546	-	4444	1646	630	1853	407
ENST00000532297	NXF1	chr11	62567848	-	ENST00000358789	KLK10	chr19	51520546	-	2919	1646	630	1853	407

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000532297	ENST00000309958	NXF1	chr11	62567848	-	KLK10	chr19	51520546	-	0.004690688	0.9953093
ENST00000532297	ENST00000391805	NXF1	chr11	62567848	-	KLK10	chr19	51520546	-	0.004671945	0.99532807
ENST00000532297	ENST00000358789	NXF1	chr11	62567848	-	KLK10	chr19	51520546	-	0.008163805	0.99183613

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Fusion Genomic Features for NXF1-KLK10

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NXF1-KLK10

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:62567848/chr19:51520546)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	KLK10 O43240
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Has a tumor-suppressor role for NES1 in breast and prostate cancer.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000294172

119_198

338

620.0

Domain

Note=RRM

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000532297

119_198

338

620.0

Domain

Note=RRM

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000294172

67_100

338

620.0

Motif

Note=Nuclear localization signal

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000294172

83_110

338

620.0

Motif

Note=Nuclear export signal

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000532297

67_100

338

620.0

Motif

Note=Nuclear localization signal

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000532297

83_110

338

620.0

Motif

Note=Nuclear export signal

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000294172

2_118

338

620.0

Region

Note=RNA-binding (RBD)

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000294172

2_60

338

620.0

Region

Note=Minor non-specific RNA-binding

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000294172

61_118

338

620.0

Region

Note=Major non-specific RNA-binding

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000532297

2_118

338

620.0

Region

Note=RNA-binding (RBD)

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000532297

2_60

338

620.0

Region

Note=Minor non-specific RNA-binding

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000532297

61_118

338

620.0

Region

Note=Major non-specific RNA-binding

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000294172

266_291

338

620.0

Repeat

Note=LRR 1

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000294172

292_315

338

620.0

Repeat

Note=LRR 2

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000532297

266_291

338

620.0

Repeat

Note=LRR 1

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000532297

292_315

338

620.0

Repeat

Note=LRR 2

Tgene

KLK10

chr11:62567848

chr19:51520546

ENST00000309958

47_274

277.0

Domain

Peptidase S1

Tgene

KLK10

chr11:62567848

chr19:51520546

ENST00000358789

47_274

277.0

Domain

Peptidase S1

Tgene

KLK10

chr11:62567848

chr19:51520546

ENST00000391805

47_274

277.0

Domain

Peptidase S1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000294172

551_561

338

620.0

Compositional bias

Note=Pro-rich

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000439713

551_561

357.0

Compositional bias

Note=Pro-rich

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000531709

551_561

380.6666666666667

Compositional bias

Note=Pro-rich

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000532297

551_561

338

620.0

Compositional bias

Note=Pro-rich

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000294172

386_536

338

620.0

Domain

NTF2

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000294172

565_619

338

620.0

Domain

TAP-C

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000439713

119_198

357.0

Domain

Note=RRM

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000439713

386_536

357.0

Domain

NTF2

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000439713

565_619

357.0

Domain

TAP-C

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000531709

119_198

380.6666666666667

Domain

Note=RRM

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000531709

386_536

380.6666666666667

Domain

NTF2

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000531709

565_619

380.6666666666667

Domain

TAP-C

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000532297

386_536

338

620.0

Domain

NTF2

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000532297

565_619

338

620.0

Domain

TAP-C

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000439713

67_100

357.0

Motif

Note=Nuclear localization signal

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000439713

83_110

357.0

Motif

Note=Nuclear export signal

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000531709

67_100

380.6666666666667

Motif

Note=Nuclear localization signal

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000531709

83_110

380.6666666666667

Motif

Note=Nuclear export signal

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000439713

2_118

357.0

Region

Note=RNA-binding (RBD)

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000439713

2_60

357.0

Region

Note=Minor non-specific RNA-binding

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000439713

61_118

357.0

Region

Note=Major non-specific RNA-binding

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000531709

2_118

380.6666666666667

Region

Note=RNA-binding (RBD)

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000531709

2_60

380.6666666666667

Region

Note=Minor non-specific RNA-binding

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000531709

61_118

380.6666666666667

Region

Note=Major non-specific RNA-binding

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000294172

316_343

338

620.0

Repeat

Note=LRR 3

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000294172

344_371

338

620.0

Repeat

Note=LRR 4

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000439713

266_291

357.0

Repeat

Note=LRR 1

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000439713

292_315

357.0

Repeat

Note=LRR 2

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000439713

316_343

357.0

Repeat

Note=LRR 3

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000439713

344_371

357.0

Repeat

Note=LRR 4

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000531709

266_291

380.6666666666667

Repeat

Note=LRR 1

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000531709

292_315

380.6666666666667

Repeat

Note=LRR 2

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000531709

316_343

380.6666666666667

Repeat

Note=LRR 3

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000531709

344_371

380.6666666666667

Repeat

Note=LRR 4

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000532297

316_343

338

620.0

Repeat

Note=LRR 3

Hgene

NXF1

chr11:62567848

chr19:51520546

ENST00000532297

344_371

338

620.0

Repeat

Note=LRR 4

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Fusion Gene Sequence for NXF1-KLK10

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>61203_61203_1_NXF1-KLK10_NXF1_chr11_62567848_ENST00000532297_KLK10_chr19_51520546_ENST00000309958_length(transcript)=4450nt_BP=1646nt
ATAGAGACAACAGTCAGGGGCTGGTGGTGGTGCTTTTGGGGGTCTAGGAGAGCCCAAGGCCCTGATATTTTAAAATGTCCTCCTCGGCAT
CTCCAGCAAGTTGCCACTGCTGGCGAAGAAAGCGAGGTATAGACAAGGAGCCGAGCTGAAACACTGGCTAGATTCCGGTAGGGGTCTGAG
CCATCACTCCCACCTGGAGGCGCGGTCTCCATTCCTCTGAAGCCCTTTGTGCGGCCCCCTTCCTCACTGAGTTCTGGGCTGCGGCGGCAG
CACTGTGCTCTAGCACTAACTCTGAAGCTGCCAGGGCAGCGTCAGCGGACAGATGAAAAGGTGCGGGGACATGCTGGCTGCCAGCCGGGG
TTCCGCAAGTTCAGGTCTTGGGCGGGGCGTGGAGGGCCAGGCCCCGCCCCTCGAACGACGGCCTTAAGTGTGCGCACGCGCAGGGGGCCG
CGCTTTCTCCGGGCGGCGGCACCGCCCACAGCCTGGGACGTCAGCGGCGCGCGACGTGCTTTGCTGTATAAATGCGGTGGCGCCCGGCGT
AGGGACACTTCGGTCCTGAGCGCTTGGGAGTTAGGTTGTTTGCCGGCGTAGCGGCCAGCGCCTGAGCCCGCCCTTGATCTTCGCTGTGGC
ATGGCGGACGAGGGGAAGTCGTACAGCGAACACGATGATGAACGCGTTAATTTCCCTCAAAGAAAGAAGAAAGGCCGGGGTCCCTTCCGG
TGGAAATATGGTGAAGGAAACCGTAGGTCTGGAAGAGGCGGTTCTGGTATTCGGTCTTCCCGCCTTGAGGAAGATGATGGAGATGTGGCA
ATGAGTGATGCCCAGGATGGTCCCCGAGTACGATACAACCCCTATACCACCCGACCTAACCGTCGGGGTGATACTTGGCATGATCGAGAT
CGCATTCATGTTACTGTGCGGAGAGACAGAGCTCCTCCAGAGAGAGGAGGGGCTGGCACCAGCCAGGATGGGACCTCAAAGAACTGGTTC
AAGATTACAATTCCTTATGGCAGAAAGTATGACAAGGCATGGCTCCTGAGCATGATTCAGAGCAAGTGCAGTGTGCCCTTCACCCCTATT
GAGTTTCACTATGAGAATACACGGGCCCAGTTCTTCGTTGAAGACGCCAGTACTGCCTCTGCATTGAAGGCTGTCAACTATAAGATTTTG
GATCGGGAGAACCGAAGGATATCTATCATCATCAACTCTTCTGCTCCACCCCACACTATACTGAATGAACTGAAGCCAGAACAAGTAGAA
CAGCTAAAGCTGATCATGAGCAAACGATACGATGGCTCCCAACAAGCCCTTGACCTCAAAGGCCTCCGTTCAGACCCAGATTTGGTGGCC
CAGAACATTGACGTTGTCCTGAATCGCAGAAGCTGTATGGCAGCTACCCTGAGGATCATTGAAGAGAACATCCCTGAGCTATTGTCCTTG
AACTTGAGCAACAACAGGCTGTACAGGCTGGATGACATGTCTAGCATTGTTCAGAAGGCACCCAACCTGAAGATCCTAAACCTTTCTGGA
AATGAATTGAAGTCTGAGCGGGAATTGGACAAGATAAAGGGGCTGAAGCTAGAAGAGCTCTGGCTCGATGGAAACTCCCTGTGTGACACC
TTCCGAGACCAGTCCACCTACATCAGCCGCAGAGGCGGCGCTGCTCCCCCAAAACGACACGCGCTTGGACCCCGAAGCCTATGGCTCCCC
GTGCGCGCGCGGCTCGCAGCCCTGGCAGGTCTCGCTCTTCAACGGCCTCTCGTTCCACTGCGCGGGTGTCCTGGTGGACCAGAGTTGGGT
GCTGACGGCCGCGCACTGCGGAAACAAGCCACTGTGGGCTCGAGTAGGGGATGACCACCTGCTGCTTCTTCAGGGAGAGCAGCTCCGCCG
GACCACTCGCTCTGTTGTCCATCCCAAGTACCACCAGGGCTCAGGCCCCATCCTGCCAAGGCGAACGGATGAGCACGATCTCATGTTGCT
GAAGCTGGCCAGGCCCGTAGTGCTGGGGCCCCGCGTCCGGGCCCTGCAGCTTCCCTACCGCTGTGCTCAGCCCGGAGACCAGTGCCAGGT
TGCTGGCTGGGGCACCACGGCCGCCCGGAGAGTGAAGTACAACAAGGGCCTGACCTGCTCCAGCATCACTATCCTGAGCCCTAAAGAGTG
TGAGGTCTTCTACCCTGGCGTGGTCACCAACAACATGATATGTGCTGGACTGGACCGGGGCCAGGACCCTTGCCAGAGTGACTCTGGAGG
CCCCCTGGTCTGTGACGAGACCCTCCAAGGCATCCTCTCGTGGGGTGTTTACCCCTGTGGCTCTGCCCAGCATCCAGCTGTCTACACCCA
GATCTGCAAATACATGTCCTGGATCAATAAAGTCATACGCTCCAACTGATCCAGATGCTACGCTCCAGCTGATCCAGATGTTATGCTCCT
GCTGATCCAGATGCCCAGAGGCTCCATCGTCCATCCTCTTCCTCCCCAGTCGGCTGAACTCTCCCCTTGTCTGCACTGTTCAAACCTCTG
CCGCCCTCCACACCTCTAAACATCTCCCCTCTCACCTCATTCCCCCACCTATCCCCATTCTCTGCCTGTACTGAAGCTGAAATGCAGGAA
GTGGTGGCAAAGGTTTATTCCAGAGAAGCCAGGAAGCCGGTCATCACCCAGCCTCTGAGAGCAGTTACTGGGGTCACCCAACCTGACTTC
CTCTGCCACTCCCTGCTGTGTGACTTTGGGCAAGCCAAGTGCCCTCTCTGAACCTCAGTTTCCTCATCTGCAAAATGGGAACAATGACGT
GCCTACCTCTTAGACATGTTGTGAGGAGACTATGATATAACATGTGTATGTAAATCTTCATGGTGATTGTCATGTAAGGCTTAACACAGT
GGGTGGTGAGTTCTGACTAAAGGTTACCTGTTGTCGTGATCTGACCACGTCCCGGTGAAAGCGTGTGTCCAGGGAAGAAGTGCACAGGGT
AGCCCCCAGTCCCAACCTTCCATCCCCAACCCTTAGGGATGATGGAAGAATCATTTTCCTCACCCTAGTTCCAAGTCCCAGGAAACACCT
TTTAACCACTTCCTTCTCATCTCCCACTGTTTCCCACTTCTGGTTCCACCCAACACCAGTTCCTCCGAGCTAGGCTGGCCCTGAGTCATT
AGCACCTTCTCTGCCTTCATGAGGCCACTGAACTCAAGGGACCTCACCTTGCTTCTATCCCAGCCTCTAAGACCAGAGGGCCGAGGGGGT
AGTGAAGATTGGGAAACCCTTGCCACCTCAACTGCCCAGCTTGTGCCAAGAAACCTCCCTCTGACATTTAGGGGAAAATCTTTGGTTTGT
CTGTTATTAATTGGCTGTGAGATTTTCGTCCTGAAAACTTGGGAGGAGGAATTGTTTGATTCTCCCTGAAATTGGGGGAGGGAAGGGGAG
TTAATACACAGAATCCAGGTAAGGCTAATAGAAGCTTCAGTGTCCGCTGGGTGTGGTGGCTCACGCCTGTAATCCTAGCACTTTGGGAGG
CCGAGGAAAGCAGATCATCTGAGGTCAGGTGTTCGAGACCAGTCTGGCCAAAATGGTGAAATCCCATCTCTACTGAAAATACAAAAACTA
GCCAGGCATGGTGGCAGGCACCTATAATCCCATCTACTTGGGAGGCTGAGGCAGAAGAATCACTTGAACCCGGGGGGCAGAGGTTGCAGT
GAGCCAAGATTGCACCATTGCACTCCATCCAGCCTGGACAAAAGAGCAAAACTCCATCTCAAAAAAAGAAGAAGTTTGAGTGTCTCAGCT
TATCCTGAACTTTGAAGCAGTAACATAAGCTAGCTGAATATAGGCACAACAGAAATTTCCCATTAAGCACGGGGTTTTTGTTTGTTTGTT
TGTCCTTTCAGTTACCAATTTATGGAGCATCTATTATGTGCCAGGCCCAGTGCTGGGTGCTGGGGACATACGTAGGGGTGATCACAAGGT
CCCCCACCCTGCAGAGCCCACAGGAGGTTGATGTACAAGGTCTGAGCACACAGCTCCCTTCCGTGGCCTCTTTCCCATTCTGCCCCCATT
AGCACACGCAGGAAATGTCAGACAGGCGTATCAGCTGGGTTTGTCATCCAAAGACCAGAAGCGAGGTCGGTGGAAACTTGAAAACTCGAT
TCATTATTAAAGGCAACTCACCCGTCCCTTTAGTCACTCCACAATGTTTATCGAGCCACGTCTTATGCCAGGCCTCAAAGATGAATCAGA
CCAGGCACTACCCTCAAGGAGCTGCTAGTTAGGTCAGGGAGACAGGCCAGTCTTACATTCCTGTCATTCAGGTCTCCACTCAAAAGTCAC
CTCCTCCGGGAGGCCTTCCTGAATTGCCCAGGCTATAGGAGTCCACTTTTGGTCATCCAGTCCCGATGCTCTGTTTTTTGTTTGTTTGTT

>61203_61203_1_NXF1-KLK10_NXF1_chr11_62567848_ENST00000532297_KLK10_chr19_51520546_ENST00000309958_length(amino acids)=407AA_BP=338
MADEGKSYSEHDDERVNFPQRKKKGRGPFRWKYGEGNRRSGRGGSGIRSSRLEEDDGDVAMSDAQDGPRVRYNPYTTRPNRRGDTWHDRD
RIHVTVRRDRAPPERGGAGTSQDGTSKNWFKITIPYGRKYDKAWLLSMIQSKCSVPFTPIEFHYENTRAQFFVEDASTASALKAVNYKIL
DRENRRISIIINSSAPPHTILNELKPEQVEQLKLIMSKRYDGSQQALDLKGLRSDPDLVAQNIDVVLNRRSCMAATLRIIEENIPELLSL
NLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELWLDGNSLCDTFRDQSTYISRRGGAAPPKRHALGPRSLWLP

--------------------------------------------------------------
>61203_61203_2_NXF1-KLK10_NXF1_chr11_62567848_ENST00000532297_KLK10_chr19_51520546_ENST00000358789_length(transcript)=2919nt_BP=1646nt
ATAGAGACAACAGTCAGGGGCTGGTGGTGGTGCTTTTGGGGGTCTAGGAGAGCCCAAGGCCCTGATATTTTAAAATGTCCTCCTCGGCAT
CTCCAGCAAGTTGCCACTGCTGGCGAAGAAAGCGAGGTATAGACAAGGAGCCGAGCTGAAACACTGGCTAGATTCCGGTAGGGGTCTGAG
CCATCACTCCCACCTGGAGGCGCGGTCTCCATTCCTCTGAAGCCCTTTGTGCGGCCCCCTTCCTCACTGAGTTCTGGGCTGCGGCGGCAG
CACTGTGCTCTAGCACTAACTCTGAAGCTGCCAGGGCAGCGTCAGCGGACAGATGAAAAGGTGCGGGGACATGCTGGCTGCCAGCCGGGG
TTCCGCAAGTTCAGGTCTTGGGCGGGGCGTGGAGGGCCAGGCCCCGCCCCTCGAACGACGGCCTTAAGTGTGCGCACGCGCAGGGGGCCG
CGCTTTCTCCGGGCGGCGGCACCGCCCACAGCCTGGGACGTCAGCGGCGCGCGACGTGCTTTGCTGTATAAATGCGGTGGCGCCCGGCGT
AGGGACACTTCGGTCCTGAGCGCTTGGGAGTTAGGTTGTTTGCCGGCGTAGCGGCCAGCGCCTGAGCCCGCCCTTGATCTTCGCTGTGGC
ATGGCGGACGAGGGGAAGTCGTACAGCGAACACGATGATGAACGCGTTAATTTCCCTCAAAGAAAGAAGAAAGGCCGGGGTCCCTTCCGG
TGGAAATATGGTGAAGGAAACCGTAGGTCTGGAAGAGGCGGTTCTGGTATTCGGTCTTCCCGCCTTGAGGAAGATGATGGAGATGTGGCA
ATGAGTGATGCCCAGGATGGTCCCCGAGTACGATACAACCCCTATACCACCCGACCTAACCGTCGGGGTGATACTTGGCATGATCGAGAT
CGCATTCATGTTACTGTGCGGAGAGACAGAGCTCCTCCAGAGAGAGGAGGGGCTGGCACCAGCCAGGATGGGACCTCAAAGAACTGGTTC
AAGATTACAATTCCTTATGGCAGAAAGTATGACAAGGCATGGCTCCTGAGCATGATTCAGAGCAAGTGCAGTGTGCCCTTCACCCCTATT
GAGTTTCACTATGAGAATACACGGGCCCAGTTCTTCGTTGAAGACGCCAGTACTGCCTCTGCATTGAAGGCTGTCAACTATAAGATTTTG
GATCGGGAGAACCGAAGGATATCTATCATCATCAACTCTTCTGCTCCACCCCACACTATACTGAATGAACTGAAGCCAGAACAAGTAGAA
CAGCTAAAGCTGATCATGAGCAAACGATACGATGGCTCCCAACAAGCCCTTGACCTCAAAGGCCTCCGTTCAGACCCAGATTTGGTGGCC
CAGAACATTGACGTTGTCCTGAATCGCAGAAGCTGTATGGCAGCTACCCTGAGGATCATTGAAGAGAACATCCCTGAGCTATTGTCCTTG
AACTTGAGCAACAACAGGCTGTACAGGCTGGATGACATGTCTAGCATTGTTCAGAAGGCACCCAACCTGAAGATCCTAAACCTTTCTGGA
AATGAATTGAAGTCTGAGCGGGAATTGGACAAGATAAAGGGGCTGAAGCTAGAAGAGCTCTGGCTCGATGGAAACTCCCTGTGTGACACC
TTCCGAGACCAGTCCACCTACATCAGCCGCAGAGGCGGCGCTGCTCCCCCAAAACGACACGCGCTTGGACCCCGAAGCCTATGGCTCCCC
GTGCGCGCGCGGCTCGCAGCCCTGGCAGGTCTCGCTCTTCAACGGCCTCTCGTTCCACTGCGCGGGTGTCCTGGTGGACCAGAGTTGGGT
GCTGACGGCCGCGCACTGCGGAAACAAGCCACTGTGGGCTCGAGTAGGGGATGACCACCTGCTGCTTCTTCAGGGAGAGCAGCTCCGCCG
GACCACTCGCTCTGTTGTCCATCCCAAGTACCACCAGGGCTCAGGCCCCATCCTGCCAAGGCGAACGGATGAGCACGATCTCATGTTGCT
GAAGCTGGCCAGGCCCGTAGTGCTGGGGCCCCGCGTCCGGGCCCTGCAGCTTCCCTACCGCTGTGCTCAGCCCGGAGACCAGTGCCAGGT
TGCTGGCTGGGGCACCACGGCCGCCCGGAGAGTGAAGTACAACAAGGGCCTGACCTGCTCCAGCATCACTATCCTGAGCCCTAAAGAGTG
TGAGGTCTTCTACCCTGGCGTGGTCACCAACAACATGATATGTGCTGGACTGGACCGGGGCCAGGACCCTTGCCAGAGTGACTCTGGAGG
CCCCCTGGTCTGTGACGAGACCCTCCAAGGCATCCTCTCGTGGGGTGTTTACCCCTGTGGCTCTGCCCAGCATCCAGCTGTCTACACCCA
GATCTGCAAATACATGTCCTGGATCAATAAAGTCATACGCTCCAACTGATCCAGATGCTACGCTCCAGCTGATCCAGATGTTATGCTCCT
GCTGATCCAGATGCCCAGAGGCTCCATCGTCCATCCTCTTCCTCCCCAGTCGGCTGAACTCTCCCCTTGTCTGCACTGTTCAAACCTCTG
CCGCCCTCCACACCTCTAAACATCTCCCCTCTCACCTCATTCCCCCACCTATCCCCATTCTCTGCCTGTACTGAAGCTGAAATGCAGGAA
GTGGTGGCAAAGGTTTATTCCAGAGAAGCCAGGAAGCCGGTCATCACCCAGCCTCTGAGAGCAGTTACTGGGGTCACCCAACCTGACTTC
CTCTGCCACTCCCTGCTGTGTGACTTTGGGCAAGCCAAGTGCCCTCTCTGAACCTCAGTTTCCTCATCTGCAAAATGGGAACAATGACGT
GCCTACCTCTTAGACATGTTGTGAGGAGACTATGATATAACATGTGTATGTAAATCTTCATGGTGATTGTCATGTAAGGCTTAACACAGT

>61203_61203_2_NXF1-KLK10_NXF1_chr11_62567848_ENST00000532297_KLK10_chr19_51520546_ENST00000358789_length(amino acids)=407AA_BP=338
MADEGKSYSEHDDERVNFPQRKKKGRGPFRWKYGEGNRRSGRGGSGIRSSRLEEDDGDVAMSDAQDGPRVRYNPYTTRPNRRGDTWHDRD
RIHVTVRRDRAPPERGGAGTSQDGTSKNWFKITIPYGRKYDKAWLLSMIQSKCSVPFTPIEFHYENTRAQFFVEDASTASALKAVNYKIL
DRENRRISIIINSSAPPHTILNELKPEQVEQLKLIMSKRYDGSQQALDLKGLRSDPDLVAQNIDVVLNRRSCMAATLRIIEENIPELLSL
NLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELWLDGNSLCDTFRDQSTYISRRGGAAPPKRHALGPRSLWLP

--------------------------------------------------------------
>61203_61203_3_NXF1-KLK10_NXF1_chr11_62567848_ENST00000532297_KLK10_chr19_51520546_ENST00000391805_length(transcript)=4444nt_BP=1646nt
ATAGAGACAACAGTCAGGGGCTGGTGGTGGTGCTTTTGGGGGTCTAGGAGAGCCCAAGGCCCTGATATTTTAAAATGTCCTCCTCGGCAT
CTCCAGCAAGTTGCCACTGCTGGCGAAGAAAGCGAGGTATAGACAAGGAGCCGAGCTGAAACACTGGCTAGATTCCGGTAGGGGTCTGAG
CCATCACTCCCACCTGGAGGCGCGGTCTCCATTCCTCTGAAGCCCTTTGTGCGGCCCCCTTCCTCACTGAGTTCTGGGCTGCGGCGGCAG
CACTGTGCTCTAGCACTAACTCTGAAGCTGCCAGGGCAGCGTCAGCGGACAGATGAAAAGGTGCGGGGACATGCTGGCTGCCAGCCGGGG
TTCCGCAAGTTCAGGTCTTGGGCGGGGCGTGGAGGGCCAGGCCCCGCCCCTCGAACGACGGCCTTAAGTGTGCGCACGCGCAGGGGGCCG
CGCTTTCTCCGGGCGGCGGCACCGCCCACAGCCTGGGACGTCAGCGGCGCGCGACGTGCTTTGCTGTATAAATGCGGTGGCGCCCGGCGT
AGGGACACTTCGGTCCTGAGCGCTTGGGAGTTAGGTTGTTTGCCGGCGTAGCGGCCAGCGCCTGAGCCCGCCCTTGATCTTCGCTGTGGC
ATGGCGGACGAGGGGAAGTCGTACAGCGAACACGATGATGAACGCGTTAATTTCCCTCAAAGAAAGAAGAAAGGCCGGGGTCCCTTCCGG
TGGAAATATGGTGAAGGAAACCGTAGGTCTGGAAGAGGCGGTTCTGGTATTCGGTCTTCCCGCCTTGAGGAAGATGATGGAGATGTGGCA
ATGAGTGATGCCCAGGATGGTCCCCGAGTACGATACAACCCCTATACCACCCGACCTAACCGTCGGGGTGATACTTGGCATGATCGAGAT
CGCATTCATGTTACTGTGCGGAGAGACAGAGCTCCTCCAGAGAGAGGAGGGGCTGGCACCAGCCAGGATGGGACCTCAAAGAACTGGTTC
AAGATTACAATTCCTTATGGCAGAAAGTATGACAAGGCATGGCTCCTGAGCATGATTCAGAGCAAGTGCAGTGTGCCCTTCACCCCTATT
GAGTTTCACTATGAGAATACACGGGCCCAGTTCTTCGTTGAAGACGCCAGTACTGCCTCTGCATTGAAGGCTGTCAACTATAAGATTTTG
GATCGGGAGAACCGAAGGATATCTATCATCATCAACTCTTCTGCTCCACCCCACACTATACTGAATGAACTGAAGCCAGAACAAGTAGAA
CAGCTAAAGCTGATCATGAGCAAACGATACGATGGCTCCCAACAAGCCCTTGACCTCAAAGGCCTCCGTTCAGACCCAGATTTGGTGGCC
CAGAACATTGACGTTGTCCTGAATCGCAGAAGCTGTATGGCAGCTACCCTGAGGATCATTGAAGAGAACATCCCTGAGCTATTGTCCTTG
AACTTGAGCAACAACAGGCTGTACAGGCTGGATGACATGTCTAGCATTGTTCAGAAGGCACCCAACCTGAAGATCCTAAACCTTTCTGGA
AATGAATTGAAGTCTGAGCGGGAATTGGACAAGATAAAGGGGCTGAAGCTAGAAGAGCTCTGGCTCGATGGAAACTCCCTGTGTGACACC
TTCCGAGACCAGTCCACCTACATCAGCCGCAGAGGCGGCGCTGCTCCCCCAAAACGACACGCGCTTGGACCCCGAAGCCTATGGCTCCCC
GTGCGCGCGCGGCTCGCAGCCCTGGCAGGTCTCGCTCTTCAACGGCCTCTCGTTCCACTGCGCGGGTGTCCTGGTGGACCAGAGTTGGGT
GCTGACGGCCGCGCACTGCGGAAACAAGCCACTGTGGGCTCGAGTAGGGGATGACCACCTGCTGCTTCTTCAGGGAGAGCAGCTCCGCCG
GACCACTCGCTCTGTTGTCCATCCCAAGTACCACCAGGGCTCAGGCCCCATCCTGCCAAGGCGAACGGATGAGCACGATCTCATGTTGCT
GAAGCTGGCCAGGCCCGTAGTGCTGGGGCCCCGCGTCCGGGCCCTGCAGCTTCCCTACCGCTGTGCTCAGCCCGGAGACCAGTGCCAGGT
TGCTGGCTGGGGCACCACGGCCGCCCGGAGAGTGAAGTACAACAAGGGCCTGACCTGCTCCAGCATCACTATCCTGAGCCCTAAAGAGTG
TGAGGTCTTCTACCCTGGCGTGGTCACCAACAACATGATATGTGCTGGACTGGACCGGGGCCAGGACCCTTGCCAGAGTGACTCTGGAGG
CCCCCTGGTCTGTGACGAGACCCTCCAAGGCATCCTCTCGTGGGGTGTTTACCCCTGTGGCTCTGCCCAGCATCCAGCTGTCTACACCCA
GATCTGCAAATACATGTCCTGGATCAATAAAGTCATACGCTCCAACTGATCCAGATGCTACGCTCCAGCTGATCCAGATGTTATGCTCCT
GCTGATCCAGATGCCCAGAGGCTCCATCGTCCATCCTCTTCCTCCCCAGTCGGCTGAACTCTCCCCTTGTCTGCACTGTTCAAACCTCTG
CCGCCCTCCACACCTCTAAACATCTCCCCTCTCACCTCATTCCCCCACCTATCCCCATTCTCTGCCTGTACTGAAGCTGAAATGCAGGAA
GTGGTGGCAAAGGTTTATTCCAGAGAAGCCAGGAAGCCGGTCATCACCCAGCCTCTGAGAGCAGTTACTGGGGTCACCCAACCTGACTTC
CTCTGCCACTCCCTGCTGTGTGACTTTGGGCAAGCCAAGTGCCCTCTCTGAACCTCAGTTTCCTCATCTGCAAAATGGGAACAATGACGT
GCCTACCTCTTAGACATGTTGTGAGGAGACTATGATATAACATGTGTATGTAAATCTTCATGGTGATTGTCATGTAAGGCTTAACACAGT
GGGTGGTGAGTTCTGACTAAAGGTTACCTGTTGTCGTGATCTGACCACGTCCCGGTGAAAGCGTGTGTCCAGGGAAGAAGTGCACAGGGT
AGCCCCCAGTCCCAACCTTCCATCCCCAACCCTTAGGGATGATGGAAGAATCATTTTCCTCACCCTAGTTCCAAGTCCCAGGAAACACCT
TTTAACCACTTCCTTCTCATCTCCCACTGTTTCCCACTTCTGGTTCCACCCAACACCAGTTCCTCCGAGCTAGGCTGGCCCTGAGTCATT
AGCACCTTCTCTGCCTTCATGAGGCCACTGAACTCAAGGGACCTCACCTTGCTTCTATCCCAGCCTCTAAGACCAGAGGGCCGAGGGGGT
AGTGAAGATTGGGAAACCCTTGCCACCTCAACTGCCCAGCTTGTGCCAAGAAACCTCCCTCTGACATTTAGGGGAAAATCTTTGGTTTGT
CTGTTATTAATTGGCTGTGAGATTTTCGTCCTGAAAACTTGGGAGGAGGAATTGTTTGATTCTCCCTGAAATTGGGGGAGGGAAGGGGAG
TTAATACACAGAATCCAGGTAAGGCTAATAGAAGCTTCAGTGTCCGCTGGGTGTGGTGGCTCACGCCTGTAATCCTAGCACTTTGGGAGG
CCGAGGAAAGCAGATCATCTGAGGTCAGGTGTTCGAGACCAGTCTGGCCAAAATGGTGAAATCCCATCTCTACTGAAAATACAAAAACTA
GCCAGGCATGGTGGCAGGCACCTATAATCCCATCTACTTGGGAGGCTGAGGCAGAAGAATCACTTGAACCCGGGGGGCAGAGGTTGCAGT
GAGCCAAGATTGCACCATTGCACTCCATCCAGCCTGGACAAAAGAGCAAAACTCCATCTCAAAAAAAGAAGAAGTTTGAGTGTCTCAGCT
TATCCTGAACTTTGAAGCAGTAACATAAGCTAGCTGAATATAGGCACAACAGAAATTTCCCATTAAGCACGGGGTTTTTGTTTGTTTGTT
TGTCCTTTCAGTTACCAATTTATGGAGCATCTATTATGTGCCAGGCCCAGTGCTGGGTGCTGGGGACATACGTAGGGGTGATCACAAGGT
CCCCCACCCTGCAGAGCCCACAGGAGGTTGATGTACAAGGTCTGAGCACACAGCTCCCTTCCGTGGCCTCTTTCCCATTCTGCCCCCATT
AGCACACGCAGGAAATGTCAGACAGGCGTATCAGCTGGGTTTGTCATCCAAAGACCAGAAGCGAGGTCGGTGGAAACTTGAAAACTCGAT
TCATTATTAAAGGCAACTCACCCGTCCCTTTAGTCACTCCACAATGTTTATCGAGCCACGTCTTATGCCAGGCCTCAAAGATGAATCAGA
CCAGGCACTACCCTCAAGGAGCTGCTAGTTAGGTCAGGGAGACAGGCCAGTCTTACATTCCTGTCATTCAGGTCTCCACTCAAAAGTCAC
CTCCTCCGGGAGGCCTTCCTGAATTGCCCAGGCTATAGGAGTCCACTTTTGGTCATCCAGTCCCGATGCTCTGTTTTTTGTTTGTTTGTT

>61203_61203_3_NXF1-KLK10_NXF1_chr11_62567848_ENST00000532297_KLK10_chr19_51520546_ENST00000391805_length(amino acids)=407AA_BP=338
MADEGKSYSEHDDERVNFPQRKKKGRGPFRWKYGEGNRRSGRGGSGIRSSRLEEDDGDVAMSDAQDGPRVRYNPYTTRPNRRGDTWHDRD
RIHVTVRRDRAPPERGGAGTSQDGTSKNWFKITIPYGRKYDKAWLLSMIQSKCSVPFTPIEFHYENTRAQFFVEDASTASALKAVNYKIL
DRENRRISIIINSSAPPHTILNELKPEQVEQLKLIMSKRYDGSQQALDLKGLRSDPDLVAQNIDVVLNRRSCMAATLRIIEENIPELLSL
NLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELWLDGNSLCDTFRDQSTYISRRGGAAPPKRHALGPRSLWLP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NXF1-KLK10

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	NXF1	chr11:62567848	chr19:51520546	ENST00000294172	-	10	21	2_198	338.6666666666667	620.0	ALYREF/THOC4 and LUZP4
Hgene	NXF1	chr11:62567848	chr19:51520546	ENST00000532297	-	11	22	2_198	338.6666666666667	620.0	ALYREF/THOC4 and LUZP4

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	NXF1	chr11:62567848	chr19:51520546	ENST00000439713	-	1	10	2_198	0	357.0	ALYREF/THOC4 and LUZP4
Hgene	NXF1	chr11:62567848	chr19:51520546	ENST00000531709	-	1	20	2_198	0	380.6666666666667	ALYREF/THOC4 and LUZP4

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for NXF1-KLK10

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for NXF1-KLK10

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source