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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NXN-WWOX (FusionGDB2 ID:61229)

Fusion Gene Summary for NXN-WWOX

check button Fusion gene summary
Fusion gene informationFusion gene name: NXN-WWOX
Fusion gene ID: 61229
HgeneTgene
Gene symbol

NXN

WWOX

Gene ID

64359

51741

Gene namenucleoredoxinWW domain containing oxidoreductase
SynonymsNRX|RRS2|TRG-4D16S432E|EIEE28|FOR|FRA16D|HHCMA56|PRO0128|SCAR12|SDR41C1|WOX1
Cytomap

17p13.3

16q23.1-q23.2

Type of geneprotein-codingprotein-coding
Descriptionnucleoredoxinnucleoredoxin 1WW domain-containing oxidoreductaseWW domain-containing protein WWOXfragile site FRA16D oxidoreductaseshort chain dehydrogenase/reductase family 41C member 1
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000336868, ENST00000537628, 
ENST00000538650, ENST00000575801, 
ENST00000577098, 		ENST00000355860, 
ENST00000408984, ENST00000565791, 
ENST00000569818, ENST00000402655, 
ENST00000406884, ENST00000566780, 
ENST00000539474, 
Fusion gene scores* DoF score16 X 13 X 11=228830 X 23 X 10=6900
# samples 2336
** MAII scorelog2(23/2288*10)=-3.31438128583401
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(36/6900*10)=-4.26052755022322
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NXN [Title/Abstract] AND WWOX [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNXN(882559)-WWOX(79245505), # samples:2
Anticipated loss of major functional domain due to fusion event.NXN-WWOX seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NXN-WWOX seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
NXN-WWOX seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneWWOX

GO:0030178

negative regulation of Wnt signaling pathway

19465938

TgeneWWOX

GO:0071560

cellular response to transforming growth factor beta stimulus

19366691


check buttonFusion gene breakpoints across NXN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across WWOX (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-2019-01ANXNchr17

882559

-WWOXchr16

79245505

+
ChimerDB4OVTCGA-24-2019NXNchr17

882558

-WWOXchr16

79245504

+


Top

Fusion Gene ORF analysis for NXN-WWOX

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000336868ENST00000355860NXNchr17

882559

-WWOXchr16

79245505

+
5CDS-intronENST00000336868ENST00000355860NXNchr17

882558

-WWOXchr16

79245504

+
5CDS-intronENST00000336868ENST00000408984NXNchr17

882559

-WWOXchr16

79245505

+
5CDS-intronENST00000336868ENST00000408984NXNchr17

882558

-WWOXchr16

79245504

+
5CDS-intronENST00000336868ENST00000565791NXNchr17

882559

-WWOXchr16

79245505

+
5CDS-intronENST00000336868ENST00000565791NXNchr17

882558

-WWOXchr16

79245504

+
5CDS-intronENST00000336868ENST00000569818NXNchr17

882559

-WWOXchr16

79245505

+
5CDS-intronENST00000336868ENST00000569818NXNchr17

882558

-WWOXchr16

79245504

+
Frame-shiftENST00000336868ENST00000402655NXNchr17

882559

-WWOXchr16

79245505

+
Frame-shiftENST00000336868ENST00000402655NXNchr17

882558

-WWOXchr16

79245504

+
Frame-shiftENST00000336868ENST00000406884NXNchr17

882559

-WWOXchr16

79245505

+
Frame-shiftENST00000336868ENST00000406884NXNchr17

882558

-WWOXchr16

79245504

+
Frame-shiftENST00000336868ENST00000566780NXNchr17

882559

-WWOXchr16

79245505

+
Frame-shiftENST00000336868ENST00000566780NXNchr17

882558

-WWOXchr16

79245504

+
In-frameENST00000336868ENST00000539474NXNchr17

882559

-WWOXchr16

79245505

+
In-frameENST00000336868ENST00000539474NXNchr17

882558

-WWOXchr16

79245504

+
intron-3CDSENST00000537628ENST00000402655NXNchr17

882559

-WWOXchr16

79245505

+
intron-3CDSENST00000537628ENST00000402655NXNchr17

882558

-WWOXchr16

79245504

+
intron-3CDSENST00000537628ENST00000406884NXNchr17

882559

-WWOXchr16

79245505

+
intron-3CDSENST00000537628ENST00000406884NXNchr17

882558

-WWOXchr16

79245504

+
intron-3CDSENST00000537628ENST00000539474NXNchr17

882559

-WWOXchr16

79245505

+
intron-3CDSENST00000537628ENST00000539474NXNchr17

882558

-WWOXchr16

79245504

+
intron-3CDSENST00000537628ENST00000566780NXNchr17

882559

-WWOXchr16

79245505

+
intron-3CDSENST00000537628ENST00000566780NXNchr17

882558

-WWOXchr16

79245504

+
intron-3CDSENST00000538650ENST00000402655NXNchr17

882559

-WWOXchr16

79245505

+
intron-3CDSENST00000538650ENST00000402655NXNchr17

882558

-WWOXchr16

79245504

+
intron-3CDSENST00000538650ENST00000406884NXNchr17

882559

-WWOXchr16

79245505

+
intron-3CDSENST00000538650ENST00000406884NXNchr17

882558

-WWOXchr16

79245504

+
intron-3CDSENST00000538650ENST00000539474NXNchr17

882559

-WWOXchr16

79245505

+
intron-3CDSENST00000538650ENST00000539474NXNchr17

882558

-WWOXchr16

79245504

+
intron-3CDSENST00000538650ENST00000566780NXNchr17

882559

-WWOXchr16

79245505

+
intron-3CDSENST00000538650ENST00000566780NXNchr17

882558

-WWOXchr16

79245504

+
intron-3CDSENST00000575801ENST00000402655NXNchr17

882559

-WWOXchr16

79245505

+
intron-3CDSENST00000575801ENST00000402655NXNchr17

882558

-WWOXchr16

79245504

+
intron-3CDSENST00000575801ENST00000406884NXNchr17

882559

-WWOXchr16

79245505

+
intron-3CDSENST00000575801ENST00000406884NXNchr17

882558

-WWOXchr16

79245504

+
intron-3CDSENST00000575801ENST00000539474NXNchr17

882559

-WWOXchr16

79245505

+
intron-3CDSENST00000575801ENST00000539474NXNchr17

882558

-WWOXchr16

79245504

+
intron-3CDSENST00000575801ENST00000566780NXNchr17

882559

-WWOXchr16

79245505

+
intron-3CDSENST00000575801ENST00000566780NXNchr17

882558

-WWOXchr16

79245504

+
intron-3CDSENST00000577098ENST00000402655NXNchr17

882559

-WWOXchr16

79245505

+
intron-3CDSENST00000577098ENST00000402655NXNchr17

882558

-WWOXchr16

79245504

+
intron-3CDSENST00000577098ENST00000406884NXNchr17

882559

-WWOXchr16

79245505

+
intron-3CDSENST00000577098ENST00000406884NXNchr17

882558

-WWOXchr16

79245504

+
intron-3CDSENST00000577098ENST00000539474NXNchr17

882559

-WWOXchr16

79245505

+
intron-3CDSENST00000577098ENST00000539474NXNchr17

882558

-WWOXchr16

79245504

+
intron-3CDSENST00000577098ENST00000566780NXNchr17

882559

-WWOXchr16

79245505

+
intron-3CDSENST00000577098ENST00000566780NXNchr17

882558

-WWOXchr16

79245504

+
intron-intronENST00000537628ENST00000355860NXNchr17

882559

-WWOXchr16

79245505

+
intron-intronENST00000537628ENST00000355860NXNchr17

882558

-WWOXchr16

79245504

+
intron-intronENST00000537628ENST00000408984NXNchr17

882559

-WWOXchr16

79245505

+
intron-intronENST00000537628ENST00000408984NXNchr17

882558

-WWOXchr16

79245504

+
intron-intronENST00000537628ENST00000565791NXNchr17

882559

-WWOXchr16

79245505

+
intron-intronENST00000537628ENST00000565791NXNchr17

882558

-WWOXchr16

79245504

+
intron-intronENST00000537628ENST00000569818NXNchr17

882559

-WWOXchr16

79245505

+
intron-intronENST00000537628ENST00000569818NXNchr17

882558

-WWOXchr16

79245504

+
intron-intronENST00000538650ENST00000355860NXNchr17

882559

-WWOXchr16

79245505

+
intron-intronENST00000538650ENST00000355860NXNchr17

882558

-WWOXchr16

79245504

+
intron-intronENST00000538650ENST00000408984NXNchr17

882559

-WWOXchr16

79245505

+
intron-intronENST00000538650ENST00000408984NXNchr17

882558

-WWOXchr16

79245504

+
intron-intronENST00000538650ENST00000565791NXNchr17

882559

-WWOXchr16

79245505

+
intron-intronENST00000538650ENST00000565791NXNchr17

882558

-WWOXchr16

79245504

+
intron-intronENST00000538650ENST00000569818NXNchr17

882559

-WWOXchr16

79245505

+
intron-intronENST00000538650ENST00000569818NXNchr17

882558

-WWOXchr16

79245504

+
intron-intronENST00000575801ENST00000355860NXNchr17

882559

-WWOXchr16

79245505

+
intron-intronENST00000575801ENST00000355860NXNchr17

882558

-WWOXchr16

79245504

+
intron-intronENST00000575801ENST00000408984NXNchr17

882559

-WWOXchr16

79245505

+
intron-intronENST00000575801ENST00000408984NXNchr17

882558

-WWOXchr16

79245504

+
intron-intronENST00000575801ENST00000565791NXNchr17

882559

-WWOXchr16

79245505

+
intron-intronENST00000575801ENST00000565791NXNchr17

882558

-WWOXchr16

79245504

+
intron-intronENST00000575801ENST00000569818NXNchr17

882559

-WWOXchr16

79245505

+
intron-intronENST00000575801ENST00000569818NXNchr17

882558

-WWOXchr16

79245504

+
intron-intronENST00000577098ENST00000355860NXNchr17

882559

-WWOXchr16

79245505

+
intron-intronENST00000577098ENST00000355860NXNchr17

882558

-WWOXchr16

79245504

+
intron-intronENST00000577098ENST00000408984NXNchr17

882559

-WWOXchr16

79245505

+
intron-intronENST00000577098ENST00000408984NXNchr17

882558

-WWOXchr16

79245504

+
intron-intronENST00000577098ENST00000565791NXNchr17

882559

-WWOXchr16

79245505

+
intron-intronENST00000577098ENST00000565791NXNchr17

882558

-WWOXchr16

79245504

+
intron-intronENST00000577098ENST00000569818NXNchr17

882559

-WWOXchr16

79245505

+
intron-intronENST00000577098ENST00000569818NXNchr17

882558

-WWOXchr16

79245504

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000336868NXNchr17882559-ENST00000539474WWOXchr1679245505+1512452208978256
ENST00000336868NXNchr17882558-ENST00000539474WWOXchr1679245504+1512452208978256

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000336868ENST00000539474NXNchr17882559-WWOXchr1679245505+0.136599120.8634009
ENST00000336868ENST00000539474NXNchr17882558-WWOXchr1679245504+0.136599120.8634009

Top

Fusion Genomic Features for NXN-WWOX


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NXNchr17882558-WWOXchr1679245504+1.15E-050.99998856
NXNchr17882558-WWOXchr1679245504+1.15E-050.99998856
NXNchr17882558-WWOXchr1679245504+1.15E-050.99998856
NXNchr17882558-WWOXchr1679245504+1.15E-050.99998856

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for NXN-WWOX


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:882559/chr16:79245505)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneWWOXchr17:882558chr16:79245504ENST000003558600616_490190.0DomainWW 1
TgeneWWOXchr17:882558chr16:79245504ENST000003558600657_900190.0DomainWW 2
TgeneWWOXchr17:882558chr16:79245504ENST0000040898401016_490311.6666666666667DomainWW 1
TgeneWWOXchr17:882558chr16:79245504ENST0000040898401057_900311.6666666666667DomainWW 2
TgeneWWOXchr17:882558chr16:79245504ENST000005698180116_49037.0DomainWW 1
TgeneWWOXchr17:882558chr16:79245504ENST000005698180157_90037.0DomainWW 2
TgeneWWOXchr17:882559chr16:79245505ENST000003558600616_490190.0DomainWW 1
TgeneWWOXchr17:882559chr16:79245505ENST000003558600657_900190.0DomainWW 2
TgeneWWOXchr17:882559chr16:79245505ENST0000040898401016_490311.6666666666667DomainWW 1
TgeneWWOXchr17:882559chr16:79245505ENST0000040898401057_900311.6666666666667DomainWW 2
TgeneWWOXchr17:882559chr16:79245505ENST000005698180116_49037.0DomainWW 1
TgeneWWOXchr17:882559chr16:79245505ENST000005698180157_90037.0DomainWW 2
TgeneWWOXchr17:882558chr16:79245504ENST000003558600650_550190.0MotifNuclear localization signal
TgeneWWOXchr17:882558chr16:79245504ENST0000040898401050_550311.6666666666667MotifNuclear localization signal
TgeneWWOXchr17:882558chr16:79245504ENST000005698180150_55037.0MotifNuclear localization signal
TgeneWWOXchr17:882559chr16:79245505ENST000003558600650_550190.0MotifNuclear localization signal
TgeneWWOXchr17:882559chr16:79245505ENST0000040898401050_550311.6666666666667MotifNuclear localization signal
TgeneWWOXchr17:882559chr16:79245505ENST000005698180150_55037.0MotifNuclear localization signal
TgeneWWOXchr17:882558chr16:79245504ENST0000035586006131_1370190.0Nucleotide bindingNADP
TgeneWWOXchr17:882558chr16:79245504ENST00000408984010131_1370311.6666666666667Nucleotide bindingNADP
TgeneWWOXchr17:882558chr16:79245504ENST0000056981801131_137037.0Nucleotide bindingNADP
TgeneWWOXchr17:882559chr16:79245505ENST0000035586006131_1370190.0Nucleotide bindingNADP
TgeneWWOXchr17:882559chr16:79245505ENST00000408984010131_1370311.6666666666667Nucleotide bindingNADP
TgeneWWOXchr17:882559chr16:79245505ENST0000056981801131_137037.0Nucleotide bindingNADP
TgeneWWOXchr17:882558chr16:79245504ENST0000035586006209_2730190.0RegionMediates targeting to the mitochondria
TgeneWWOXchr17:882558chr16:79245504ENST0000040265535209_273136312.0RegionMediates targeting to the mitochondria
TgeneWWOXchr17:882558chr16:79245504ENST0000040688446209_273172235.0RegionMediates targeting to the mitochondria
TgeneWWOXchr17:882558chr16:79245504ENST00000408984010209_2730311.6666666666667RegionMediates targeting to the mitochondria
TgeneWWOXchr17:882558chr16:79245504ENST0000056981801209_273037.0RegionMediates targeting to the mitochondria
TgeneWWOXchr17:882559chr16:79245505ENST0000035586006209_2730190.0RegionMediates targeting to the mitochondria
TgeneWWOXchr17:882559chr16:79245505ENST0000040265535209_273136312.0RegionMediates targeting to the mitochondria
TgeneWWOXchr17:882559chr16:79245505ENST0000040688446209_273172235.0RegionMediates targeting to the mitochondria
TgeneWWOXchr17:882559chr16:79245505ENST00000408984010209_2730311.6666666666667RegionMediates targeting to the mitochondria
TgeneWWOXchr17:882559chr16:79245505ENST0000056981801209_273037.0RegionMediates targeting to the mitochondria

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNXNchr17:882558chr16:79245504ENST00000336868-18167_321120436.0DomainThioredoxin
HgeneNXNchr17:882558chr16:79245504ENST00000537628-18167_3210187.0DomainThioredoxin
HgeneNXNchr17:882558chr16:79245504ENST00000575801-18167_3210328.0DomainThioredoxin
HgeneNXNchr17:882559chr16:79245505ENST00000336868-18167_321120436.0DomainThioredoxin
HgeneNXNchr17:882559chr16:79245505ENST00000537628-18167_3210187.0DomainThioredoxin
HgeneNXNchr17:882559chr16:79245505ENST00000575801-18167_3210328.0DomainThioredoxin
TgeneWWOXchr17:882558chr16:79245504ENST000004026553516_49136312.0DomainWW 1
TgeneWWOXchr17:882558chr16:79245504ENST000004026553557_90136312.0DomainWW 2
TgeneWWOXchr17:882558chr16:79245504ENST000004068844616_49172235.0DomainWW 1
TgeneWWOXchr17:882558chr16:79245504ENST000004068844657_90172235.0DomainWW 2
TgeneWWOXchr17:882558chr16:79245504ENST000005667807916_49352415.0DomainWW 1
TgeneWWOXchr17:882558chr16:79245504ENST000005667807957_90352415.0DomainWW 2
TgeneWWOXchr17:882559chr16:79245505ENST000004026553516_49136312.0DomainWW 1
TgeneWWOXchr17:882559chr16:79245505ENST000004026553557_90136312.0DomainWW 2
TgeneWWOXchr17:882559chr16:79245505ENST000004068844616_49172235.0DomainWW 1
TgeneWWOXchr17:882559chr16:79245505ENST000004068844657_90172235.0DomainWW 2
TgeneWWOXchr17:882559chr16:79245505ENST000005667807916_49352415.0DomainWW 1
TgeneWWOXchr17:882559chr16:79245505ENST000005667807957_90352415.0DomainWW 2
TgeneWWOXchr17:882558chr16:79245504ENST000004026553550_55136312.0MotifNuclear localization signal
TgeneWWOXchr17:882558chr16:79245504ENST000004068844650_55172235.0MotifNuclear localization signal
TgeneWWOXchr17:882558chr16:79245504ENST000005667807950_55352415.0MotifNuclear localization signal
TgeneWWOXchr17:882559chr16:79245505ENST000004026553550_55136312.0MotifNuclear localization signal
TgeneWWOXchr17:882559chr16:79245505ENST000004068844650_55172235.0MotifNuclear localization signal
TgeneWWOXchr17:882559chr16:79245505ENST000005667807950_55352415.0MotifNuclear localization signal
TgeneWWOXchr17:882558chr16:79245504ENST0000040265535131_137136312.0Nucleotide bindingNADP
TgeneWWOXchr17:882558chr16:79245504ENST0000040688446131_137172235.0Nucleotide bindingNADP
TgeneWWOXchr17:882558chr16:79245504ENST0000056678079131_137352415.0Nucleotide bindingNADP
TgeneWWOXchr17:882559chr16:79245505ENST0000040265535131_137136312.0Nucleotide bindingNADP
TgeneWWOXchr17:882559chr16:79245505ENST0000040688446131_137172235.0Nucleotide bindingNADP
TgeneWWOXchr17:882559chr16:79245505ENST0000056678079131_137352415.0Nucleotide bindingNADP
TgeneWWOXchr17:882558chr16:79245504ENST0000056678079209_273352415.0RegionMediates targeting to the mitochondria
TgeneWWOXchr17:882559chr16:79245505ENST0000056678079209_273352415.0RegionMediates targeting to the mitochondria


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Fusion Gene Sequence for NXN-WWOX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>61229_61229_1_NXN-WWOX_NXN_chr17_882558_ENST00000336868_WWOX_chr16_79245504_ENST00000539474_length(transcript)=1512nt_BP=452nt
CCCAGCGCCTGCCGCCGACGCCGCCGCCTCCTCCCGCCGCGCGGACCGTGGAGCGGGGTCGCAGCCGCCTGCCCGCCCTGCGGTGGGCCA
GGATGTCGGGCTTCCTGGAGGAGCTGCTCGGCGAGAAGCTGGTGACGGGCGGCGGCGAGGAGGTGGACGTGCACTCGCTGGGCGCCCGCG
GCATCTCGCTGCTGGGTCTCTACTTCGGCTGCAGCCTCAGCGCCCCCTGCGCGCAGCTCAGCGCCAGCCTGGCCGCCTTCTACGGGCGCC
TGCGGGGGGACGCGGCGGCCGGGCCGGGGCCGGGAGCGGGGGCCGGGGCGGCGGCGGAGCCCGAGCCGCGGCGGCGCCTGGAGATCGTCT
TCGTGTCCTCGGACCAGGACCAGCGGCAGTGGCAGGACTTCGTGCGGGACATGCCGTGGCTGGCGCTGCCCTACAAGGAGAAGCACAGGA
AGCAACAGGGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGAGGGATGTACTTCAACAACTGCTGCCGCT
GCATGCCCTCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCGAGAGGCTGATCCAAGAACGGCTTGGCAGCC
AGTCCGGCTAAGTGGAGCTCAGAGCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCCTCACGCAAGTGCCAGGGCTGGGCCCCTTCC
AAATGTCCCTCCAACACAGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCACAACAGAGTGAAAAATCTTAAGTACCAATGGGAAGCAGG
GAATTCCTGGGGTAAAGTATCACTTTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTTTCTGGTGGTGGCCTGTTTGAAAGTAAAAAC
CTGCTTGGTGTGTAGGTTCCGTATCTCCCTGGAGAAGCACCAGCAATTCTCTTTCTTTTACTGTTATAGAATAGCCTGAGGTCCCCTCGT
CCCATCCAGCTACCACCACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTCCTACTTAGGGAAGAAAAAGCAAGTGTTCACTGCTCCTTG
CTGCATTGATCCAGGAGATAATTGTTTCATTCATCCTGACCAAGACTGAGCCAGCTTAGCAACTGCTGGGGAGACAAATCTCAGAACCTT
GTCCCAGCCAGTGAGGATGACAGTGACACCCAGAGGGAGTAGAATACGCAGAACTACCAGGTGGCAAAGTACTTGTCATAGACTCCTTTG
CTAATGCTATGCAAAAAATTCTTTAGAGATTATAACAAATTTTTCAAATCATTCCTTAGATACCTTGAAAGGCAGGAAGGGAAGCGTATA
TACTTAAGAATACACAGGATATTTTGGGGGGCAGAGAATAAAACGTTAGTTAATCCCTTTGTCTGTCAATCACAGTCTCAGTTCTCTTGC

>61229_61229_1_NXN-WWOX_NXN_chr17_882558_ENST00000336868_WWOX_chr16_79245504_ENST00000539474_length(amino acids)=256AA_BP=81
MQPQRPLRAAQRQPGRLLRAPAGGRGGRAGAGSGGRGGGGARAAAAPGDRLRVLGPGPAAVAGLRAGHAVAGAALQGEAQEATGSCHHRV
LCCCPRTGGSGRDVLQQLLPLHALTRSSERRDGPDPVGAQREADPRTAWQPVRLSGAQSGWAHTPALCVSPHASARAGPLPNVPPTQIRK

--------------------------------------------------------------
>61229_61229_2_NXN-WWOX_NXN_chr17_882559_ENST00000336868_WWOX_chr16_79245505_ENST00000539474_length(transcript)=1512nt_BP=452nt
CCCAGCGCCTGCCGCCGACGCCGCCGCCTCCTCCCGCCGCGCGGACCGTGGAGCGGGGTCGCAGCCGCCTGCCCGCCCTGCGGTGGGCCA
GGATGTCGGGCTTCCTGGAGGAGCTGCTCGGCGAGAAGCTGGTGACGGGCGGCGGCGAGGAGGTGGACGTGCACTCGCTGGGCGCCCGCG
GCATCTCGCTGCTGGGTCTCTACTTCGGCTGCAGCCTCAGCGCCCCCTGCGCGCAGCTCAGCGCCAGCCTGGCCGCCTTCTACGGGCGCC
TGCGGGGGGACGCGGCGGCCGGGCCGGGGCCGGGAGCGGGGGCCGGGGCGGCGGCGGAGCCCGAGCCGCGGCGGCGCCTGGAGATCGTCT
TCGTGTCCTCGGACCAGGACCAGCGGCAGTGGCAGGACTTCGTGCGGGACATGCCGTGGCTGGCGCTGCCCTACAAGGAGAAGCACAGGA
AGCAACAGGGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGAGGGATGTACTTCAACAACTGCTGCCGCT
GCATGCCCTCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCGAGAGGCTGATCCAAGAACGGCTTGGCAGCC
AGTCCGGCTAAGTGGAGCTCAGAGCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCCTCACGCAAGTGCCAGGGCTGGGCCCCTTCC
AAATGTCCCTCCAACACAGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCACAACAGAGTGAAAAATCTTAAGTACCAATGGGAAGCAGG
GAATTCCTGGGGTAAAGTATCACTTTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTTTCTGGTGGTGGCCTGTTTGAAAGTAAAAAC
CTGCTTGGTGTGTAGGTTCCGTATCTCCCTGGAGAAGCACCAGCAATTCTCTTTCTTTTACTGTTATAGAATAGCCTGAGGTCCCCTCGT
CCCATCCAGCTACCACCACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTCCTACTTAGGGAAGAAAAAGCAAGTGTTCACTGCTCCTTG
CTGCATTGATCCAGGAGATAATTGTTTCATTCATCCTGACCAAGACTGAGCCAGCTTAGCAACTGCTGGGGAGACAAATCTCAGAACCTT
GTCCCAGCCAGTGAGGATGACAGTGACACCCAGAGGGAGTAGAATACGCAGAACTACCAGGTGGCAAAGTACTTGTCATAGACTCCTTTG
CTAATGCTATGCAAAAAATTCTTTAGAGATTATAACAAATTTTTCAAATCATTCCTTAGATACCTTGAAAGGCAGGAAGGGAAGCGTATA
TACTTAAGAATACACAGGATATTTTGGGGGGCAGAGAATAAAACGTTAGTTAATCCCTTTGTCTGTCAATCACAGTCTCAGTTCTCTTGC

>61229_61229_2_NXN-WWOX_NXN_chr17_882559_ENST00000336868_WWOX_chr16_79245505_ENST00000539474_length(amino acids)=256AA_BP=81
MQPQRPLRAAQRQPGRLLRAPAGGRGGRAGAGSGGRGGGGARAAAAPGDRLRVLGPGPAAVAGLRAGHAVAGAALQGEAQEATGSCHHRV
LCCCPRTGGSGRDVLQQLLPLHALTRSSERRDGPDPVGAQREADPRTAWQPVRLSGAQSGWAHTPALCVSPHASARAGPLPNVPPTQIRK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NXN-WWOX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneWWOXchr17:882558chr16:79245504ENST0000035586006125_4140190.0MAPT
TgeneWWOXchr17:882558chr16:79245504ENST00000408984010125_4140311.6666666666667MAPT
TgeneWWOXchr17:882558chr16:79245504ENST0000056981801125_414037.0MAPT
TgeneWWOXchr17:882559chr16:79245505ENST0000035586006125_4140190.0MAPT
TgeneWWOXchr17:882559chr16:79245505ENST00000408984010125_4140311.6666666666667MAPT
TgeneWWOXchr17:882559chr16:79245505ENST0000056981801125_414037.0MAPT


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneWWOXchr17:882558chr16:79245504ENST0000040265535125_414136.33333333333334312.0MAPT
TgeneWWOXchr17:882558chr16:79245504ENST0000040688446125_414172.0235.0MAPT
TgeneWWOXchr17:882558chr16:79245504ENST0000056678079125_414352.0415.0MAPT
TgeneWWOXchr17:882559chr16:79245505ENST0000040265535125_414136.33333333333334312.0MAPT
TgeneWWOXchr17:882559chr16:79245505ENST0000040688446125_414172.0235.0MAPT
TgeneWWOXchr17:882559chr16:79245505ENST0000056678079125_414352.0415.0MAPT


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NXN-WWOX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NXN-WWOX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource