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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGAP44-MBP (FusionGDB2 ID:6123)

Fusion Gene Summary for ARHGAP44-MBP

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP44-MBP
Fusion gene ID: 6123
HgeneTgene
Gene symbol

ARHGAP44

MBP

Gene ID

9912

5553

Gene nameRho GTPase activating protein 44proteoglycan 2, pro eosinophil major basic protein
SynonymsNPC-A-10|RICH2BMPG|MBP|MBP1|proMBP
Cytomap

17p12

11q12.1

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 44Rho-type GTPase-activating protein RICH2RhoGAP interacting with CIP4 homologs protein 2rho GTPase-activating protein RICH2bone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Modification date2020031320200313
UniProtAcc

Q17R89

P02686

Ensembl transtripts involved in fusion geneENST00000262444, ENST00000340825, 
ENST00000379672, ENST00000578087, 
ENST00000354542, ENST00000355994, 
ENST00000382582, ENST00000397860, 
ENST00000397863, ENST00000397865, 
ENST00000397866, ENST00000397869, 
ENST00000397875, ENST00000487778, 
ENST00000526111, ENST00000527041, 
ENST00000528160, ENST00000578193, 
ENST00000579129, ENST00000580402, 
ENST00000359645, 
Fusion gene scores* DoF score9 X 8 X 6=43232 X 27 X 4=3456
# samples 932
** MAII scorelog2(9/432*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(32/3456*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP44 [Title/Abstract] AND MBP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP44(12856032)-MBP(74729011), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARHGAP44 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MBP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADT218537ARHGAP44chr17

12856032

-MBPchr18

74729011

-


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Fusion Gene ORF analysis for ARHGAP44-MBP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000262444ENST00000354542ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000262444ENST00000355994ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000262444ENST00000382582ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000262444ENST00000397860ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000262444ENST00000397863ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000262444ENST00000397865ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000262444ENST00000397866ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000262444ENST00000397869ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000262444ENST00000397875ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000262444ENST00000487778ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000262444ENST00000526111ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000262444ENST00000527041ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000262444ENST00000528160ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000262444ENST00000578193ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000262444ENST00000579129ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000262444ENST00000580402ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000340825ENST00000354542ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000340825ENST00000355994ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000340825ENST00000382582ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000340825ENST00000397860ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000340825ENST00000397863ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000340825ENST00000397865ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000340825ENST00000397866ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000340825ENST00000397869ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000340825ENST00000397875ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000340825ENST00000487778ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000340825ENST00000526111ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000340825ENST00000527041ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000340825ENST00000528160ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000340825ENST00000578193ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000340825ENST00000579129ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000340825ENST00000580402ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000379672ENST00000354542ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000379672ENST00000355994ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000379672ENST00000382582ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000379672ENST00000397860ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000379672ENST00000397863ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000379672ENST00000397865ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000379672ENST00000397866ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000379672ENST00000397869ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000379672ENST00000397875ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000379672ENST00000487778ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000379672ENST00000526111ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000379672ENST00000527041ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000379672ENST00000528160ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000379672ENST00000578193ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000379672ENST00000579129ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000379672ENST00000580402ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000578087ENST00000354542ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000578087ENST00000355994ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000578087ENST00000382582ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000578087ENST00000397860ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000578087ENST00000397863ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000578087ENST00000397865ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000578087ENST00000397866ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000578087ENST00000397869ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000578087ENST00000397875ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000578087ENST00000487778ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000578087ENST00000526111ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000578087ENST00000527041ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000578087ENST00000528160ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000578087ENST00000578193ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000578087ENST00000579129ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-5UTRENST00000578087ENST00000580402ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-intronENST00000262444ENST00000359645ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-intronENST00000340825ENST00000359645ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-intronENST00000379672ENST00000359645ARHGAP44chr17

12856032

-MBPchr18

74729011

-
intron-intronENST00000578087ENST00000359645ARHGAP44chr17

12856032

-MBPchr18

74729011

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ARHGAP44-MBP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARHGAP44-MBP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:12856032/:74729011)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP44

Q17R89

MBP

P02686

FUNCTION: GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed:11431473). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (By similarity). Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation (By similarity). In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation (By similarity). {ECO:0000250|UniProtKB:F1LQX4, ECO:0000250|UniProtKB:Q5SSM3, ECO:0000269|PubMed:11431473}.FUNCTION: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269|PubMed:8544862}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ARHGAP44-MBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ARHGAP44-MBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGAP44-MBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGAP44-MBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource