FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:OAZ1-HMGB1 (FusionGDB2 ID:61279)

Fusion Gene Summary for OAZ1-HMGB1

check button Fusion gene summary
Fusion gene informationFusion gene name: OAZ1-HMGB1
Fusion gene ID: 61279
HgeneTgene
Gene symbol

OAZ1

HMGB1

Gene ID

4946

3146

Gene nameornithine decarboxylase antizyme 1high mobility group box 1
SynonymsAZ1|AZI|OAZHMG-1|HMG1|HMG3|SBP-1
Cytomap

19p13.3

13q12.3

Type of geneprotein-codingprotein-coding
Descriptionornithine decarboxylase antizyme 1ODC-Azantizyme 1high mobility group protein B1AmphoterinSulfoglucuronyl carbohydrate binding proteinhigh-mobility group (nonhistone chromosomal) protein 1
Modification date2020031320200329
UniProtAcc.

P09429

Ensembl transtripts involved in fusion geneENST00000322297, ENST00000582888, 
ENST00000583542, ENST00000602676, 
ENST00000588673, 		ENST00000326004, 
ENST00000339872, ENST00000341423, 
ENST00000399489, ENST00000399494, 
ENST00000405805, ENST00000468384, 
Fusion gene scores* DoF score19 X 7 X 8=106428 X 10 X 6=1680
# samples 1721
** MAII scorelog2(17/1064*10)=-2.64589149936349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/1680*10)=-3
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OAZ1 [Title/Abstract] AND HMGB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointOAZ1(2269743)-HMGB1(31037831), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOAZ1

GO:0045732

positive regulation of protein catabolic process

17900240

TgeneHMGB1

GO:0002218

activation of innate immune response

24971542

TgeneHMGB1

GO:0002643

regulation of tolerance induction

18631454

TgeneHMGB1

GO:0006357

regulation of transcription by RNA polymerase II

11748232

TgeneHMGB1

GO:0006954

inflammatory response

23146691

TgeneHMGB1

GO:0007204

positive regulation of cytosolic calcium ion concentration

22370717

TgeneHMGB1

GO:0017055

negative regulation of RNA polymerase II transcriptional preinitiation complex assembly

8006019

TgeneHMGB1

GO:0032072

regulation of restriction endodeoxyribonuclease activity

17803946

TgeneHMGB1

GO:0032425

positive regulation of mismatch repair

15014079

TgeneHMGB1

GO:0032689

negative regulation of interferon-gamma production

22473704

TgeneHMGB1

GO:0032733

positive regulation of interleukin-10 production

22473704

TgeneHMGB1

GO:0032755

positive regulation of interleukin-6 production

26961863

TgeneHMGB1

GO:0032757

positive regulation of interleukin-8 production

26961863

TgeneHMGB1

GO:0033151

V(D)J recombination

9166431

TgeneHMGB1

GO:0035711

T-helper 1 cell activation

22473704

TgeneHMGB1

GO:0043065

positive regulation of apoptotic process

19800306

TgeneHMGB1

GO:0043277

apoptotic cell clearance

18768881

TgeneHMGB1

GO:0043280

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

19800306

TgeneHMGB1

GO:0043371

negative regulation of CD4-positive, alpha-beta T cell differentiation

22473704

TgeneHMGB1

GO:0043388

positive regulation of DNA binding

11748232|19223331

TgeneHMGB1

GO:0043410

positive regulation of MAPK cascade

12765338

TgeneHMGB1

GO:0043537

negative regulation of blood vessel endothelial cell migration

23148224

TgeneHMGB1

GO:0045944

positive regulation of transcription by RNA polymerase II

19223331

TgeneHMGB1

GO:0046330

positive regulation of JNK cascade

12765338

TgeneHMGB1

GO:0050716

positive regulation of interleukin-1 secretion

12765338

TgeneHMGB1

GO:0070374

positive regulation of ERK1 and ERK2 cascade

22370717

TgeneHMGB1

GO:0090026

positive regulation of monocyte chemotaxis

22370717

TgeneHMGB1

GO:0097350

neutrophil clearance

18768881

TgeneHMGB1

GO:1990774

tumor necrosis factor secretion

12765338

TgeneHMGB1

GO:2000343

positive regulation of chemokine (C-X-C motif) ligand 2 production

26961863

TgeneHMGB1

GO:2000426

negative regulation of apoptotic cell clearance

20826760

TgeneHMGB1

GO:2000778

positive regulation of interleukin-6 secretion

12765338


check buttonFusion gene breakpoints across OAZ1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across HMGB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315404OAZ1chr19

2269743

+HMGB1chr13

31037831

-


Top

Fusion Gene ORF analysis for OAZ1-HMGB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000322297ENST00000326004OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000322297ENST00000339872OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000322297ENST00000341423OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000322297ENST00000399489OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000322297ENST00000399494OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000322297ENST00000405805OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000322297ENST00000468384OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000582888ENST00000326004OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000582888ENST00000339872OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000582888ENST00000341423OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000582888ENST00000399489OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000582888ENST00000399494OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000582888ENST00000405805OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000582888ENST00000468384OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000583542ENST00000326004OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000583542ENST00000339872OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000583542ENST00000341423OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000583542ENST00000399489OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000583542ENST00000399494OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000583542ENST00000405805OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000583542ENST00000468384OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000602676ENST00000326004OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000602676ENST00000339872OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000602676ENST00000341423OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000602676ENST00000399489OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000602676ENST00000399494OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000602676ENST00000405805OAZ1chr19

2269743

+HMGB1chr13

31037831

-
5CDS-5UTRENST00000602676ENST00000468384OAZ1chr19

2269743

+HMGB1chr13

31037831

-
intron-5UTRENST00000588673ENST00000326004OAZ1chr19

2269743

+HMGB1chr13

31037831

-
intron-5UTRENST00000588673ENST00000339872OAZ1chr19

2269743

+HMGB1chr13

31037831

-
intron-5UTRENST00000588673ENST00000341423OAZ1chr19

2269743

+HMGB1chr13

31037831

-
intron-5UTRENST00000588673ENST00000399489OAZ1chr19

2269743

+HMGB1chr13

31037831

-
intron-5UTRENST00000588673ENST00000399494OAZ1chr19

2269743

+HMGB1chr13

31037831

-
intron-5UTRENST00000588673ENST00000405805OAZ1chr19

2269743

+HMGB1chr13

31037831

-
intron-5UTRENST00000588673ENST00000468384OAZ1chr19

2269743

+HMGB1chr13

31037831

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for OAZ1-HMGB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for OAZ1-HMGB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:2269743/:31037831)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HMGB1

P09429

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability (Ref.71). Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury (PubMed:27362237). Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P12682, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:23303669, ECO:0000269|PubMed:25549101, ECO:0000269|PubMed:27362237, ECO:0000269|Ref.71, ECO:0000305|PubMed:23446148, ECO:0000305|PubMed:23519706, ECO:0000305|PubMed:23994764, ECO:0000305|PubMed:25048472}.; FUNCTION: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:20123072). May have an enhancing role in nucleotide excision repair (NER) (By similarity). However, effects in NER using in vitro systems have been reported conflictingly (PubMed:19446504, PubMed:19360789). May be involved in mismatch repair (MMR) and base excision repair (BER) pathways (PubMed:15014079, PubMed:16143102, PubMed:17803946). May be involved in double strand break repair such as non-homologous end joining (NHEJ) (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). In vitro can displace histone H1 from highly bent DNA (By similarity). Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding (By similarity). Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities (By similarity). Facilitates binding of TP53 to DNA (PubMed:23063560). Proposed to be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1; however, this function has been questioned (By similarity). Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:15014079, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:17803946, ECO:0000269|PubMed:19446504, ECO:0000269|PubMed:23063560, ECO:0000305|PubMed:19360789, ECO:0000305|PubMed:20123072}.; FUNCTION: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation (PubMed:20819940). Involved in oxidative stress-mediated autophagy (PubMed:21395369). Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury (By similarity). In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy (By similarity). Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity). {ECO:0000250|UniProtKB:P63158, ECO:0000269|PubMed:20819940, ECO:0000269|PubMed:21395369}.; FUNCTION: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22370717). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (By similarity). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (PubMed:24971542). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:12765338, PubMed:18354232, PubMed:19264983, PubMed:20547845, PubMed:24474694). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12 (PubMed:15607795). TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2 (PubMed:20547845). In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (PubMed:18354232, PubMed:21660935, PubMed:25660311). Contributes to tumor proliferation by association with ACER/RAGE (By similarity). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (PubMed:18250463). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (By similarity). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells (By similarity). In adaptive immunity may be involved in enhancing immunity through activation of effector T cells and suppression of regulatory T (TReg) cells (PubMed:15944249, PubMed:22473704). In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression (By similarity). Also reported to limit proliferation of T-cells (By similarity). Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production (PubMed:19064698). Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106 (PubMed:18631454). During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:12765338, ECO:0000269|PubMed:15607795, ECO:0000269|PubMed:15944249, ECO:0000269|PubMed:18250463, ECO:0000269|PubMed:18354232, ECO:0000269|PubMed:18631454, ECO:0000269|PubMed:19064698, ECO:0000269|PubMed:19264983, ECO:0000269|PubMed:20547845, ECO:0000269|PubMed:21660935, ECO:0000269|PubMed:22370717, ECO:0000269|PubMed:22473704, ECO:0000269|PubMed:24474694, ECO:0000269|PubMed:24971542, ECO:0000269|PubMed:25660311, ECO:0000269|Ref.8}.; FUNCTION: (Microbial infection) Critical for entry of human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63. Regulates the expression of the pro-viral genes ACE2 and CTSL through chromatin modulation. {ECO:0000269|Ref.71}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for OAZ1-HMGB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for OAZ1-HMGB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for OAZ1-HMGB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for OAZ1-HMGB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource