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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:OBSL1-STK11IP (FusionGDB2 ID:61314)

Fusion Gene Summary for OBSL1-STK11IP

Fusion gene summary

Fusion gene information	Fusion gene name: OBSL1-STK11IP
	Fusion gene ID: 61314
		Hgene	Tgene
	Gene symbol	OBSL1	STK11IP
	Gene ID	23363	114790
	Gene name	obscurin like cytoskeletal adaptor 1	serine/threonine kinase 11 interacting protein
	Synonyms	-	LIP1\|LKB1IP\|STK11IP1
	Cytomap	2q35	2q35
	Type of gene	protein-coding	protein-coding
	Description	obscurin-like protein 1obscurin like 1	serine/threonine-protein kinase 11-interacting proteinLKB1-interacting protein 1STK11 interacting protein
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000265318, ENST00000289656, ENST00000373873, ENST00000373876, ENST00000404537, ENST00000603926, ENST00000265317, ENST00000491370,	ENST00000459692, ENST00000295641, ENST00000456909,
Fusion gene scores	* DoF score	5 X 7 X 5=175	1 X 5 X 1=5
	# samples	5	1
	** MAII score	log2(5/175*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/5*10)=1
Context	PubMed: OBSL1 [Title/Abstract] AND STK11IP [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	OBSL1(220429328)-STK11IP(220468678), # samples:1 OBSL1(220429963)-STK11IP(220466430), # samples:1 OBSL1(220429963)-STK11IP(220466488), # samples:1 OBSL1(220429963)-STK11IP(220468194), # samples:1 OBSL1(220430127)-STK11IP(220467497), # samples:1 OBSL1(220431310)-STK11IP(220467497), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	STK11IP	GO:0008104	protein localization	11741830

Fusion gene breakpoints across OBSL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across STK11IP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-23-1023-01R	OBSL1	chr2	220429328	-	STK11IP	chr2	220468678	-
ChimerDB4	OV	TCGA-23-1023-01R	OBSL1	chr2	220429963	-	STK11IP	chr2	220466430	-
ChimerDB4	OV	TCGA-23-1023-01R	OBSL1	chr2	220429963	-	STK11IP	chr2	220466488	-
ChimerDB4	OV	TCGA-23-1023-01R	OBSL1	chr2	220429963	-	STK11IP	chr2	220468194	-
ChimerDB4	OV	TCGA-23-1023-01R	OBSL1	chr2	220430127	-	STK11IP	chr2	220467497	-
ChimerDB4	OV	TCGA-23-1023-01R	OBSL1	chr2	220431310	-	STK11IP	chr2	220467497	-

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Fusion Gene ORF analysis for OBSL1-STK11IP

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000265318	ENST00000459692	OBSL1	chr2	220429963	-	STK11IP	chr2	220466430	-
5CDS-3UTR	ENST00000289656	ENST00000459692	OBSL1	chr2	220429963	-	STK11IP	chr2	220466430	-
5CDS-3UTR	ENST00000373873	ENST00000459692	OBSL1	chr2	220429963	-	STK11IP	chr2	220466430	-
5CDS-3UTR	ENST00000373876	ENST00000459692	OBSL1	chr2	220429963	-	STK11IP	chr2	220466430	-
5CDS-3UTR	ENST00000404537	ENST00000459692	OBSL1	chr2	220429963	-	STK11IP	chr2	220466430	-
5CDS-3UTR	ENST00000603926	ENST00000459692	OBSL1	chr2	220429963	-	STK11IP	chr2	220466430	-
5CDS-intron	ENST00000265318	ENST00000295641	OBSL1	chr2	220429963	-	STK11IP	chr2	220466488	-
5CDS-intron	ENST00000265318	ENST00000295641	OBSL1	chr2	220429963	-	STK11IP	chr2	220468194	-
5CDS-intron	ENST00000265318	ENST00000456909	OBSL1	chr2	220429963	-	STK11IP	chr2	220466488	-
5CDS-intron	ENST00000265318	ENST00000456909	OBSL1	chr2	220429963	-	STK11IP	chr2	220468194	-
5CDS-intron	ENST00000265318	ENST00000459692	OBSL1	chr2	220429963	-	STK11IP	chr2	220466488	-
5CDS-intron	ENST00000265318	ENST00000459692	OBSL1	chr2	220429963	-	STK11IP	chr2	220468194	-
5CDS-intron	ENST00000289656	ENST00000295641	OBSL1	chr2	220429963	-	STK11IP	chr2	220466488	-
5CDS-intron	ENST00000289656	ENST00000295641	OBSL1	chr2	220429963	-	STK11IP	chr2	220468194	-
5CDS-intron	ENST00000289656	ENST00000456909	OBSL1	chr2	220429963	-	STK11IP	chr2	220466488	-
5CDS-intron	ENST00000289656	ENST00000456909	OBSL1	chr2	220429963	-	STK11IP	chr2	220468194	-
5CDS-intron	ENST00000289656	ENST00000459692	OBSL1	chr2	220429963	-	STK11IP	chr2	220466488	-
5CDS-intron	ENST00000289656	ENST00000459692	OBSL1	chr2	220429963	-	STK11IP	chr2	220468194	-
5CDS-intron	ENST00000373873	ENST00000295641	OBSL1	chr2	220429963	-	STK11IP	chr2	220466488	-
5CDS-intron	ENST00000373873	ENST00000295641	OBSL1	chr2	220429963	-	STK11IP	chr2	220468194	-
5CDS-intron	ENST00000373873	ENST00000456909	OBSL1	chr2	220429963	-	STK11IP	chr2	220466488	-
5CDS-intron	ENST00000373873	ENST00000456909	OBSL1	chr2	220429963	-	STK11IP	chr2	220468194	-
5CDS-intron	ENST00000373873	ENST00000459692	OBSL1	chr2	220429963	-	STK11IP	chr2	220466488	-
5CDS-intron	ENST00000373873	ENST00000459692	OBSL1	chr2	220429963	-	STK11IP	chr2	220468194	-
5CDS-intron	ENST00000373876	ENST00000295641	OBSL1	chr2	220429963	-	STK11IP	chr2	220466488	-
5CDS-intron	ENST00000373876	ENST00000295641	OBSL1	chr2	220429963	-	STK11IP	chr2	220468194	-
5CDS-intron	ENST00000373876	ENST00000456909	OBSL1	chr2	220429963	-	STK11IP	chr2	220466488	-
5CDS-intron	ENST00000373876	ENST00000456909	OBSL1	chr2	220429963	-	STK11IP	chr2	220468194	-
5CDS-intron	ENST00000373876	ENST00000459692	OBSL1	chr2	220429963	-	STK11IP	chr2	220466488	-
5CDS-intron	ENST00000373876	ENST00000459692	OBSL1	chr2	220429963	-	STK11IP	chr2	220468194	-
5CDS-intron	ENST00000404537	ENST00000295641	OBSL1	chr2	220429963	-	STK11IP	chr2	220466488	-
5CDS-intron	ENST00000404537	ENST00000295641	OBSL1	chr2	220429963	-	STK11IP	chr2	220468194	-
5CDS-intron	ENST00000404537	ENST00000456909	OBSL1	chr2	220429963	-	STK11IP	chr2	220466488	-
5CDS-intron	ENST00000404537	ENST00000456909	OBSL1	chr2	220429963	-	STK11IP	chr2	220468194	-
5CDS-intron	ENST00000404537	ENST00000459692	OBSL1	chr2	220429963	-	STK11IP	chr2	220466488	-
5CDS-intron	ENST00000404537	ENST00000459692	OBSL1	chr2	220429963	-	STK11IP	chr2	220468194	-
5CDS-intron	ENST00000603926	ENST00000295641	OBSL1	chr2	220429963	-	STK11IP	chr2	220466488	-
5CDS-intron	ENST00000603926	ENST00000295641	OBSL1	chr2	220429963	-	STK11IP	chr2	220468194	-
5CDS-intron	ENST00000603926	ENST00000456909	OBSL1	chr2	220429963	-	STK11IP	chr2	220466488	-
5CDS-intron	ENST00000603926	ENST00000456909	OBSL1	chr2	220429963	-	STK11IP	chr2	220468194	-
5CDS-intron	ENST00000603926	ENST00000459692	OBSL1	chr2	220429963	-	STK11IP	chr2	220466488	-
5CDS-intron	ENST00000603926	ENST00000459692	OBSL1	chr2	220429963	-	STK11IP	chr2	220468194	-
Frame-shift	ENST00000289656	ENST00000295641	OBSL1	chr2	220429963	-	STK11IP	chr2	220466430	-
Frame-shift	ENST00000289656	ENST00000456909	OBSL1	chr2	220429963	-	STK11IP	chr2	220466430	-
Frame-shift	ENST00000373873	ENST00000295641	OBSL1	chr2	220429963	-	STK11IP	chr2	220466430	-
Frame-shift	ENST00000373873	ENST00000456909	OBSL1	chr2	220429963	-	STK11IP	chr2	220466430	-
Frame-shift	ENST00000373876	ENST00000295641	OBSL1	chr2	220429963	-	STK11IP	chr2	220466430	-
Frame-shift	ENST00000373876	ENST00000456909	OBSL1	chr2	220429963	-	STK11IP	chr2	220466430	-
Frame-shift	ENST00000404537	ENST00000295641	OBSL1	chr2	220429963	-	STK11IP	chr2	220466430	-
Frame-shift	ENST00000404537	ENST00000456909	OBSL1	chr2	220429963	-	STK11IP	chr2	220466430	-
Frame-shift	ENST00000603926	ENST00000295641	OBSL1	chr2	220429963	-	STK11IP	chr2	220466430	-
Frame-shift	ENST00000603926	ENST00000456909	OBSL1	chr2	220429963	-	STK11IP	chr2	220466430	-
In-frame	ENST00000265318	ENST00000295641	OBSL1	chr2	220429963	-	STK11IP	chr2	220466430	-
In-frame	ENST00000265318	ENST00000456909	OBSL1	chr2	220429963	-	STK11IP	chr2	220466430	-
intron-3CDS	ENST00000265317	ENST00000295641	OBSL1	chr2	220429963	-	STK11IP	chr2	220466430	-
intron-3CDS	ENST00000265317	ENST00000456909	OBSL1	chr2	220429963	-	STK11IP	chr2	220466430	-
intron-3CDS	ENST00000491370	ENST00000295641	OBSL1	chr2	220429963	-	STK11IP	chr2	220466430	-
intron-3CDS	ENST00000491370	ENST00000456909	OBSL1	chr2	220429963	-	STK11IP	chr2	220466430	-
intron-3UTR	ENST00000265317	ENST00000459692	OBSL1	chr2	220429963	-	STK11IP	chr2	220466430	-
intron-3UTR	ENST00000491370	ENST00000459692	OBSL1	chr2	220429963	-	STK11IP	chr2	220466430	-
intron-intron	ENST00000265317	ENST00000295641	OBSL1	chr2	220429328	-	STK11IP	chr2	220468678	-
intron-intron	ENST00000265317	ENST00000295641	OBSL1	chr2	220429963	-	STK11IP	chr2	220466488	-
intron-intron	ENST00000265317	ENST00000295641	OBSL1	chr2	220429963	-	STK11IP	chr2	220468194	-
intron-intron	ENST00000265317	ENST00000295641	OBSL1	chr2	220430127	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000265317	ENST00000295641	OBSL1	chr2	220431310	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000265317	ENST00000456909	OBSL1	chr2	220429328	-	STK11IP	chr2	220468678	-
intron-intron	ENST00000265317	ENST00000456909	OBSL1	chr2	220429963	-	STK11IP	chr2	220466488	-
intron-intron	ENST00000265317	ENST00000456909	OBSL1	chr2	220429963	-	STK11IP	chr2	220468194	-
intron-intron	ENST00000265317	ENST00000456909	OBSL1	chr2	220430127	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000265317	ENST00000456909	OBSL1	chr2	220431310	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000265317	ENST00000459692	OBSL1	chr2	220429328	-	STK11IP	chr2	220468678	-
intron-intron	ENST00000265317	ENST00000459692	OBSL1	chr2	220429963	-	STK11IP	chr2	220466488	-
intron-intron	ENST00000265317	ENST00000459692	OBSL1	chr2	220429963	-	STK11IP	chr2	220468194	-
intron-intron	ENST00000265317	ENST00000459692	OBSL1	chr2	220430127	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000265317	ENST00000459692	OBSL1	chr2	220431310	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000265318	ENST00000295641	OBSL1	chr2	220429328	-	STK11IP	chr2	220468678	-
intron-intron	ENST00000265318	ENST00000295641	OBSL1	chr2	220430127	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000265318	ENST00000295641	OBSL1	chr2	220431310	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000265318	ENST00000456909	OBSL1	chr2	220429328	-	STK11IP	chr2	220468678	-
intron-intron	ENST00000265318	ENST00000456909	OBSL1	chr2	220430127	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000265318	ENST00000456909	OBSL1	chr2	220431310	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000265318	ENST00000459692	OBSL1	chr2	220429328	-	STK11IP	chr2	220468678	-
intron-intron	ENST00000265318	ENST00000459692	OBSL1	chr2	220430127	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000265318	ENST00000459692	OBSL1	chr2	220431310	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000289656	ENST00000295641	OBSL1	chr2	220429328	-	STK11IP	chr2	220468678	-
intron-intron	ENST00000289656	ENST00000295641	OBSL1	chr2	220430127	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000289656	ENST00000295641	OBSL1	chr2	220431310	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000289656	ENST00000456909	OBSL1	chr2	220429328	-	STK11IP	chr2	220468678	-
intron-intron	ENST00000289656	ENST00000456909	OBSL1	chr2	220430127	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000289656	ENST00000456909	OBSL1	chr2	220431310	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000289656	ENST00000459692	OBSL1	chr2	220429328	-	STK11IP	chr2	220468678	-
intron-intron	ENST00000289656	ENST00000459692	OBSL1	chr2	220430127	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000289656	ENST00000459692	OBSL1	chr2	220431310	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000373873	ENST00000295641	OBSL1	chr2	220429328	-	STK11IP	chr2	220468678	-
intron-intron	ENST00000373873	ENST00000295641	OBSL1	chr2	220430127	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000373873	ENST00000295641	OBSL1	chr2	220431310	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000373873	ENST00000456909	OBSL1	chr2	220429328	-	STK11IP	chr2	220468678	-
intron-intron	ENST00000373873	ENST00000456909	OBSL1	chr2	220430127	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000373873	ENST00000456909	OBSL1	chr2	220431310	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000373873	ENST00000459692	OBSL1	chr2	220429328	-	STK11IP	chr2	220468678	-
intron-intron	ENST00000373873	ENST00000459692	OBSL1	chr2	220430127	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000373873	ENST00000459692	OBSL1	chr2	220431310	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000373876	ENST00000295641	OBSL1	chr2	220429328	-	STK11IP	chr2	220468678	-
intron-intron	ENST00000373876	ENST00000295641	OBSL1	chr2	220430127	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000373876	ENST00000295641	OBSL1	chr2	220431310	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000373876	ENST00000456909	OBSL1	chr2	220429328	-	STK11IP	chr2	220468678	-
intron-intron	ENST00000373876	ENST00000456909	OBSL1	chr2	220430127	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000373876	ENST00000456909	OBSL1	chr2	220431310	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000373876	ENST00000459692	OBSL1	chr2	220429328	-	STK11IP	chr2	220468678	-
intron-intron	ENST00000373876	ENST00000459692	OBSL1	chr2	220430127	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000373876	ENST00000459692	OBSL1	chr2	220431310	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000404537	ENST00000295641	OBSL1	chr2	220429328	-	STK11IP	chr2	220468678	-
intron-intron	ENST00000404537	ENST00000295641	OBSL1	chr2	220430127	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000404537	ENST00000295641	OBSL1	chr2	220431310	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000404537	ENST00000456909	OBSL1	chr2	220429328	-	STK11IP	chr2	220468678	-
intron-intron	ENST00000404537	ENST00000456909	OBSL1	chr2	220430127	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000404537	ENST00000456909	OBSL1	chr2	220431310	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000404537	ENST00000459692	OBSL1	chr2	220429328	-	STK11IP	chr2	220468678	-
intron-intron	ENST00000404537	ENST00000459692	OBSL1	chr2	220430127	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000404537	ENST00000459692	OBSL1	chr2	220431310	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000491370	ENST00000295641	OBSL1	chr2	220429328	-	STK11IP	chr2	220468678	-
intron-intron	ENST00000491370	ENST00000295641	OBSL1	chr2	220429963	-	STK11IP	chr2	220466488	-
intron-intron	ENST00000491370	ENST00000295641	OBSL1	chr2	220429963	-	STK11IP	chr2	220468194	-
intron-intron	ENST00000491370	ENST00000295641	OBSL1	chr2	220430127	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000491370	ENST00000295641	OBSL1	chr2	220431310	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000491370	ENST00000456909	OBSL1	chr2	220429328	-	STK11IP	chr2	220468678	-
intron-intron	ENST00000491370	ENST00000456909	OBSL1	chr2	220429963	-	STK11IP	chr2	220466488	-
intron-intron	ENST00000491370	ENST00000456909	OBSL1	chr2	220429963	-	STK11IP	chr2	220468194	-
intron-intron	ENST00000491370	ENST00000456909	OBSL1	chr2	220430127	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000491370	ENST00000456909	OBSL1	chr2	220431310	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000491370	ENST00000459692	OBSL1	chr2	220429328	-	STK11IP	chr2	220468678	-
intron-intron	ENST00000491370	ENST00000459692	OBSL1	chr2	220429963	-	STK11IP	chr2	220466488	-
intron-intron	ENST00000491370	ENST00000459692	OBSL1	chr2	220429963	-	STK11IP	chr2	220468194	-
intron-intron	ENST00000491370	ENST00000459692	OBSL1	chr2	220430127	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000491370	ENST00000459692	OBSL1	chr2	220431310	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000603926	ENST00000295641	OBSL1	chr2	220429328	-	STK11IP	chr2	220468678	-
intron-intron	ENST00000603926	ENST00000295641	OBSL1	chr2	220430127	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000603926	ENST00000295641	OBSL1	chr2	220431310	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000603926	ENST00000456909	OBSL1	chr2	220429328	-	STK11IP	chr2	220468678	-
intron-intron	ENST00000603926	ENST00000456909	OBSL1	chr2	220430127	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000603926	ENST00000456909	OBSL1	chr2	220431310	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000603926	ENST00000459692	OBSL1	chr2	220429328	-	STK11IP	chr2	220468678	-
intron-intron	ENST00000603926	ENST00000459692	OBSL1	chr2	220430127	-	STK11IP	chr2	220467497	-
intron-intron	ENST00000603926	ENST00000459692	OBSL1	chr2	220431310	-	STK11IP	chr2	220467497	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for OBSL1-STK11IP

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for OBSL1-STK11IP

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:220429328/chr2:220468678)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000373873

128_225

802

1026.0

Domain

Note=Ig-like 2

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000373873

12_100

802

1026.0

Domain

Note=Ig-like 1

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000373873

243_330

802

1026.0

Domain

Note=Ig-like 3

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000373873

339_425

802

1026.0

Domain

Note=Ig-like 4

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000373873

517_615

802

1026.0

Domain

Fibronectin type-III

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000373873

714_800

802

1026.0

Domain

Note=Ig-like 5

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000404537

128_225

802

1897.0

Domain

Note=Ig-like 2

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000404537

12_100

802

1897.0

Domain

Note=Ig-like 1

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000404537

243_330

802

1897.0

Domain

Note=Ig-like 3

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000404537

339_425

802

1897.0

Domain

Note=Ig-like 4

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000404537

517_615

802

1897.0

Domain

Fibronectin type-III

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000404537

714_800

802

1897.0

Domain

Note=Ig-like 5

Tgene

STK11IP

chr2:220429963

chr2:220466430

ENST00000295641

474_593

1100.0

Compositional bias

Note=Glu-rich

Tgene

STK11IP

chr2:220429963

chr2:220466430

ENST00000295641

109_130

1100.0

Repeat

Note=LRR 1

Tgene

STK11IP

chr2:220429963

chr2:220466430

ENST00000295641

132_152

1100.0

Repeat

Note=LRR 2

Tgene

STK11IP

chr2:220429963

chr2:220466430

ENST00000295641

164_185

1100.0

Repeat

Note=LRR 3

Tgene

STK11IP

chr2:220429963

chr2:220466430

ENST00000295641

187_209

1100.0

Repeat

Note=LRR 4

Tgene

STK11IP

chr2:220429963

chr2:220466430

ENST00000295641

210_231

1100.0

Repeat

Note=LRR 5

Tgene

STK11IP

chr2:220429963

chr2:220466430

ENST00000295641

233_254

1100.0

Repeat

Note=LRR 6

Tgene

STK11IP

chr2:220429963

chr2:220466430

ENST00000295641

255_276

1100.0

Repeat

Note=LRR 7

Tgene

STK11IP

chr2:220429963

chr2:220466430

ENST00000295641

280_301

1100.0

Repeat

Note=LRR 8

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000373873

1078_1172

802

1026.0

Domain

Note=Ig-like 9

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000373873

1174_1261

802

1026.0

Domain

Note=Ig-like 10

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000373873

1265_1357

802

1026.0

Domain

Note=Ig-like 11

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000373873

1357_1534

802

1026.0

Domain

Note=Ig-like 12

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000373873

1628_1720

802

1026.0

Domain

Note=Ig-like 13

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000373873

1794_1896

802

1026.0

Domain

Note=Ig-like 14

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000373873

804_893

802

1026.0

Domain

Note=Ig-like 6

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000373873

902_982

802

1026.0

Domain

Note=Ig-like 7

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000373873

986_1075

802

1026.0

Domain

Note=Ig-like 8

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000404537

1078_1172

802

1897.0

Domain

Note=Ig-like 9

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000404537

1174_1261

802

1897.0

Domain

Note=Ig-like 10

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000404537

1265_1357

802

1897.0

Domain

Note=Ig-like 11

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000404537

1357_1534

802

1897.0

Domain

Note=Ig-like 12

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000404537

1628_1720

802

1897.0

Domain

Note=Ig-like 13

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000404537

1794_1896

802

1897.0

Domain

Note=Ig-like 14

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000404537

804_893

802

1897.0

Domain

Note=Ig-like 6

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000404537

902_982

802

1897.0

Domain

Note=Ig-like 7

Hgene

OBSL1

chr2:220429963

chr2:220466430

ENST00000404537

986_1075

802

1897.0

Domain

Note=Ig-like 8

Top

Fusion Gene Sequence for OBSL1-STK11IP

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for OBSL1-STK11IP

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	OBSL1	chr2:220429963	chr2:220466430	ENST00000373873	-	6	9	17_19	802.3333333333334	1026.0	TTN
Hgene	OBSL1	chr2:220429963	chr2:220466430	ENST00000373873	-	6	9	85_94	802.3333333333334	1026.0	TTN
Hgene	OBSL1	chr2:220429963	chr2:220466430	ENST00000404537	-	6	21	17_19	802.3333333333334	1897.0	TTN
Hgene	OBSL1	chr2:220429963	chr2:220466430	ENST00000404537	-	6	21	85_94	802.3333333333334	1897.0	TTN

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for OBSL1-STK11IP

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for OBSL1-STK11IP

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source