Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:OCEL1-USE1 (FusionGDB2 ID:61320)

Fusion Gene Summary for OCEL1-USE1

Fusion gene summary

Fusion gene information	Fusion gene name: OCEL1-USE1
	Fusion gene ID: 61320
		Hgene	Tgene
	Gene symbol	OCEL1	USE1
	Gene ID	79629	65264
	Gene name	occludin/ELL domain containing 1	ubiquitin conjugating enzyme E2 Z
	Synonyms	FWP009\|S863-9	HOYS7\|USE1
	Cytomap	19p13.11	17q21.32
	Type of gene	protein-coding	protein-coding
	Description	occludin/ELL domain-containing protein 1	ubiquitin-conjugating enzyme E2 ZE2 ubiquitin-conjugating enzyme ZUBA6-specific enzyme E2uba6-specific E2 conjugating enzyme 1ubiquitin carrier protein Zubiquitin conjugating enzyme E2Zubiquitin-protein ligase Z
	Modification date	20200320	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000601576, ENST00000215061, ENST00000597836, ENST00000601529,	ENST00000263897, ENST00000445667, ENST00000379776, ENST00000595101, ENST00000596136,
Fusion gene scores	* DoF score	3 X 5 X 3=45	4 X 4 X 4=64
	# samples	3	4
	** MAII score	log2(3/45*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: OCEL1 [Title/Abstract] AND USE1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	OCEL1(17337125)-USE1(17330022), # samples:2
Anticipated loss of major functional domain due to fusion event.	OCEL1-USE1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	USE1	GO:0043065	positive regulation of apoptotic process	17464193

Fusion gene breakpoints across OCEL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across USE1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-A5-A7WK-01A	OCEL1	chr19	17337125	-	USE1	chr19	17330022	+
ChimerDB4	UCEC	TCGA-A5-A7WK	OCEL1	chr19	17337125	+	USE1	chr19	17330022	+
ChimerDB4	UCEC	TCGA-A5-A7WK	OCEL1	chr19	17337162	+	USE1	chr19	17330440	+
ChimerDB4	UCEC	TCGA-A5-A7WK	OCEL1	chr19	17338008	+	USE1	chr19	17330022	+
ChimerDB4	UCEC	TCGA-A5-A7WK	OCEL1	chr19	17338008	+	USE1	chr19	17330440	+
ChimerDB4	UCEC	TCGA-A5-A7WK	OCEL1	chr19	17338814	+	USE1	chr19	17329173	+

Top

Fusion Gene ORF analysis for OCEL1-USE1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000601576	ENST00000263897	OCEL1	chr19	17337125	+	USE1	chr19	17330022	+
3UTR-3CDS	ENST00000601576	ENST00000263897	OCEL1	chr19	17337162	+	USE1	chr19	17330440	+
3UTR-3CDS	ENST00000601576	ENST00000263897	OCEL1	chr19	17338008	+	USE1	chr19	17330022	+
3UTR-3CDS	ENST00000601576	ENST00000263897	OCEL1	chr19	17338008	+	USE1	chr19	17330440	+
3UTR-3CDS	ENST00000601576	ENST00000445667	OCEL1	chr19	17337125	+	USE1	chr19	17330022	+
3UTR-3CDS	ENST00000601576	ENST00000445667	OCEL1	chr19	17337162	+	USE1	chr19	17330440	+
3UTR-3CDS	ENST00000601576	ENST00000445667	OCEL1	chr19	17338008	+	USE1	chr19	17330022	+
3UTR-3CDS	ENST00000601576	ENST00000445667	OCEL1	chr19	17338008	+	USE1	chr19	17330440	+
3UTR-intron	ENST00000601576	ENST00000379776	OCEL1	chr19	17337125	+	USE1	chr19	17330022	+
3UTR-intron	ENST00000601576	ENST00000379776	OCEL1	chr19	17337162	+	USE1	chr19	17330440	+
3UTR-intron	ENST00000601576	ENST00000379776	OCEL1	chr19	17338008	+	USE1	chr19	17330022	+
3UTR-intron	ENST00000601576	ENST00000379776	OCEL1	chr19	17338008	+	USE1	chr19	17330440	+
3UTR-intron	ENST00000601576	ENST00000595101	OCEL1	chr19	17337125	+	USE1	chr19	17330022	+
3UTR-intron	ENST00000601576	ENST00000595101	OCEL1	chr19	17337162	+	USE1	chr19	17330440	+
3UTR-intron	ENST00000601576	ENST00000595101	OCEL1	chr19	17338008	+	USE1	chr19	17330022	+
3UTR-intron	ENST00000601576	ENST00000595101	OCEL1	chr19	17338008	+	USE1	chr19	17330440	+
3UTR-intron	ENST00000601576	ENST00000596136	OCEL1	chr19	17337125	+	USE1	chr19	17330022	+
3UTR-intron	ENST00000601576	ENST00000596136	OCEL1	chr19	17337162	+	USE1	chr19	17330440	+
3UTR-intron	ENST00000601576	ENST00000596136	OCEL1	chr19	17338008	+	USE1	chr19	17330022	+
3UTR-intron	ENST00000601576	ENST00000596136	OCEL1	chr19	17338008	+	USE1	chr19	17330440	+
5CDS-3UTR	ENST00000215061	ENST00000379776	OCEL1	chr19	17338814	+	USE1	chr19	17329173	+
5CDS-3UTR	ENST00000215061	ENST00000595101	OCEL1	chr19	17338814	+	USE1	chr19	17329173	+
5CDS-3UTR	ENST00000215061	ENST00000596136	OCEL1	chr19	17338814	+	USE1	chr19	17329173	+
5CDS-3UTR	ENST00000597836	ENST00000379776	OCEL1	chr19	17338814	+	USE1	chr19	17329173	+
5CDS-3UTR	ENST00000597836	ENST00000595101	OCEL1	chr19	17338814	+	USE1	chr19	17329173	+
5CDS-3UTR	ENST00000597836	ENST00000596136	OCEL1	chr19	17338814	+	USE1	chr19	17329173	+
5CDS-intron	ENST00000215061	ENST00000379776	OCEL1	chr19	17337125	+	USE1	chr19	17330022	+
5CDS-intron	ENST00000215061	ENST00000379776	OCEL1	chr19	17338008	+	USE1	chr19	17330022	+
5CDS-intron	ENST00000215061	ENST00000379776	OCEL1	chr19	17338008	+	USE1	chr19	17330440	+
5CDS-intron	ENST00000215061	ENST00000595101	OCEL1	chr19	17337125	+	USE1	chr19	17330022	+
5CDS-intron	ENST00000215061	ENST00000595101	OCEL1	chr19	17338008	+	USE1	chr19	17330022	+
5CDS-intron	ENST00000215061	ENST00000595101	OCEL1	chr19	17338008	+	USE1	chr19	17330440	+
5CDS-intron	ENST00000215061	ENST00000596136	OCEL1	chr19	17337125	+	USE1	chr19	17330022	+
5CDS-intron	ENST00000215061	ENST00000596136	OCEL1	chr19	17338008	+	USE1	chr19	17330022	+
5CDS-intron	ENST00000215061	ENST00000596136	OCEL1	chr19	17338008	+	USE1	chr19	17330440	+
5CDS-intron	ENST00000597836	ENST00000379776	OCEL1	chr19	17338008	+	USE1	chr19	17330022	+
5CDS-intron	ENST00000597836	ENST00000379776	OCEL1	chr19	17338008	+	USE1	chr19	17330440	+
5CDS-intron	ENST00000597836	ENST00000595101	OCEL1	chr19	17338008	+	USE1	chr19	17330022	+
5CDS-intron	ENST00000597836	ENST00000595101	OCEL1	chr19	17338008	+	USE1	chr19	17330440	+
5CDS-intron	ENST00000597836	ENST00000596136	OCEL1	chr19	17338008	+	USE1	chr19	17330022	+
5CDS-intron	ENST00000597836	ENST00000596136	OCEL1	chr19	17338008	+	USE1	chr19	17330440	+
5CDS-intron	ENST00000601529	ENST00000379776	OCEL1	chr19	17337125	+	USE1	chr19	17330022	+
5CDS-intron	ENST00000601529	ENST00000379776	OCEL1	chr19	17338008	+	USE1	chr19	17330022	+
5CDS-intron	ENST00000601529	ENST00000379776	OCEL1	chr19	17338008	+	USE1	chr19	17330440	+
5CDS-intron	ENST00000601529	ENST00000595101	OCEL1	chr19	17337125	+	USE1	chr19	17330022	+
5CDS-intron	ENST00000601529	ENST00000595101	OCEL1	chr19	17338008	+	USE1	chr19	17330022	+
5CDS-intron	ENST00000601529	ENST00000595101	OCEL1	chr19	17338008	+	USE1	chr19	17330440	+
5CDS-intron	ENST00000601529	ENST00000596136	OCEL1	chr19	17337125	+	USE1	chr19	17330022	+
5CDS-intron	ENST00000601529	ENST00000596136	OCEL1	chr19	17338008	+	USE1	chr19	17330022	+
5CDS-intron	ENST00000601529	ENST00000596136	OCEL1	chr19	17338008	+	USE1	chr19	17330440	+
Frame-shift	ENST00000215061	ENST00000263897	OCEL1	chr19	17337125	+	USE1	chr19	17330022	+
Frame-shift	ENST00000215061	ENST00000263897	OCEL1	chr19	17338814	+	USE1	chr19	17329173	+
Frame-shift	ENST00000215061	ENST00000445667	OCEL1	chr19	17337125	+	USE1	chr19	17330022	+
Frame-shift	ENST00000215061	ENST00000445667	OCEL1	chr19	17338814	+	USE1	chr19	17329173	+
Frame-shift	ENST00000597836	ENST00000263897	OCEL1	chr19	17338814	+	USE1	chr19	17329173	+
Frame-shift	ENST00000597836	ENST00000445667	OCEL1	chr19	17338814	+	USE1	chr19	17329173	+
Frame-shift	ENST00000601529	ENST00000263897	OCEL1	chr19	17337125	+	USE1	chr19	17330022	+
Frame-shift	ENST00000601529	ENST00000445667	OCEL1	chr19	17337125	+	USE1	chr19	17330022	+
In-frame	ENST00000215061	ENST00000263897	OCEL1	chr19	17338008	+	USE1	chr19	17330022	+
In-frame	ENST00000215061	ENST00000263897	OCEL1	chr19	17338008	+	USE1	chr19	17330440	+
In-frame	ENST00000215061	ENST00000445667	OCEL1	chr19	17338008	+	USE1	chr19	17330022	+
In-frame	ENST00000215061	ENST00000445667	OCEL1	chr19	17338008	+	USE1	chr19	17330440	+
In-frame	ENST00000597836	ENST00000263897	OCEL1	chr19	17338008	+	USE1	chr19	17330022	+
In-frame	ENST00000597836	ENST00000263897	OCEL1	chr19	17338008	+	USE1	chr19	17330440	+
In-frame	ENST00000597836	ENST00000445667	OCEL1	chr19	17338008	+	USE1	chr19	17330022	+
In-frame	ENST00000597836	ENST00000445667	OCEL1	chr19	17338008	+	USE1	chr19	17330440	+
In-frame	ENST00000601529	ENST00000263897	OCEL1	chr19	17338008	+	USE1	chr19	17330022	+
In-frame	ENST00000601529	ENST00000263897	OCEL1	chr19	17338008	+	USE1	chr19	17330440	+
In-frame	ENST00000601529	ENST00000445667	OCEL1	chr19	17338008	+	USE1	chr19	17330022	+
In-frame	ENST00000601529	ENST00000445667	OCEL1	chr19	17338008	+	USE1	chr19	17330440	+
intron-3CDS	ENST00000215061	ENST00000263897	OCEL1	chr19	17337162	+	USE1	chr19	17330440	+
intron-3CDS	ENST00000215061	ENST00000445667	OCEL1	chr19	17337162	+	USE1	chr19	17330440	+
intron-3CDS	ENST00000597836	ENST00000263897	OCEL1	chr19	17337125	+	USE1	chr19	17330022	+
intron-3CDS	ENST00000597836	ENST00000263897	OCEL1	chr19	17337162	+	USE1	chr19	17330440	+
intron-3CDS	ENST00000597836	ENST00000445667	OCEL1	chr19	17337125	+	USE1	chr19	17330022	+
intron-3CDS	ENST00000597836	ENST00000445667	OCEL1	chr19	17337162	+	USE1	chr19	17330440	+
intron-3CDS	ENST00000601529	ENST00000263897	OCEL1	chr19	17337162	+	USE1	chr19	17330440	+
intron-3CDS	ENST00000601529	ENST00000263897	OCEL1	chr19	17338814	+	USE1	chr19	17329173	+
intron-3CDS	ENST00000601529	ENST00000445667	OCEL1	chr19	17337162	+	USE1	chr19	17330440	+
intron-3CDS	ENST00000601529	ENST00000445667	OCEL1	chr19	17338814	+	USE1	chr19	17329173	+
intron-3CDS	ENST00000601576	ENST00000263897	OCEL1	chr19	17338814	+	USE1	chr19	17329173	+
intron-3CDS	ENST00000601576	ENST00000445667	OCEL1	chr19	17338814	+	USE1	chr19	17329173	+
intron-3UTR	ENST00000601529	ENST00000379776	OCEL1	chr19	17338814	+	USE1	chr19	17329173	+
intron-3UTR	ENST00000601529	ENST00000595101	OCEL1	chr19	17338814	+	USE1	chr19	17329173	+
intron-3UTR	ENST00000601529	ENST00000596136	OCEL1	chr19	17338814	+	USE1	chr19	17329173	+
intron-3UTR	ENST00000601576	ENST00000379776	OCEL1	chr19	17338814	+	USE1	chr19	17329173	+
intron-3UTR	ENST00000601576	ENST00000595101	OCEL1	chr19	17338814	+	USE1	chr19	17329173	+
intron-3UTR	ENST00000601576	ENST00000596136	OCEL1	chr19	17338814	+	USE1	chr19	17329173	+
intron-intron	ENST00000215061	ENST00000379776	OCEL1	chr19	17337162	+	USE1	chr19	17330440	+
intron-intron	ENST00000215061	ENST00000595101	OCEL1	chr19	17337162	+	USE1	chr19	17330440	+
intron-intron	ENST00000215061	ENST00000596136	OCEL1	chr19	17337162	+	USE1	chr19	17330440	+
intron-intron	ENST00000597836	ENST00000379776	OCEL1	chr19	17337125	+	USE1	chr19	17330022	+
intron-intron	ENST00000597836	ENST00000379776	OCEL1	chr19	17337162	+	USE1	chr19	17330440	+
intron-intron	ENST00000597836	ENST00000595101	OCEL1	chr19	17337125	+	USE1	chr19	17330022	+
intron-intron	ENST00000597836	ENST00000595101	OCEL1	chr19	17337162	+	USE1	chr19	17330440	+
intron-intron	ENST00000597836	ENST00000596136	OCEL1	chr19	17337125	+	USE1	chr19	17330022	+
intron-intron	ENST00000597836	ENST00000596136	OCEL1	chr19	17337162	+	USE1	chr19	17330440	+
intron-intron	ENST00000601529	ENST00000379776	OCEL1	chr19	17337162	+	USE1	chr19	17330440	+
intron-intron	ENST00000601529	ENST00000595101	OCEL1	chr19	17337162	+	USE1	chr19	17330440	+
intron-intron	ENST00000601529	ENST00000596136	OCEL1	chr19	17337162	+	USE1	chr19	17330440	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for OCEL1-USE1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
OCEL1	chr19	17338814	+	USE1	chr19	17329172	+	0.1920497	0.8079503
OCEL1	chr19	17338008	+	USE1	chr19	17330439	+	0.00234829	0.99765176
OCEL1	chr19	17338008	+	USE1	chr19	17330021	+	0.000261382	0.99973863
OCEL1	chr19	17337162	+	USE1	chr19	17330439	+	9.08E-06	0.99999094
OCEL1	chr19	17337125	+	USE1	chr19	17330021	+	6.88E-07	0.9999993
OCEL1	chr19	17338814	+	USE1	chr19	17329172	+	0.1920497	0.8079503
OCEL1	chr19	17338008	+	USE1	chr19	17330439	+	0.00234829	0.99765176
OCEL1	chr19	17338008	+	USE1	chr19	17330021	+	0.000261382	0.99973863
OCEL1	chr19	17337162	+	USE1	chr19	17330439	+	9.08E-06	0.99999094
OCEL1	chr19	17337125	+	USE1	chr19	17330021	+	6.88E-07	0.9999993

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for OCEL1-USE1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:17337125/chr19:17330022)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

OCEL1

chr19:17338008

chr19:17330022

ENST00000215061

28_106

150

265.0

Compositional bias

Note=Pro-rich

Hgene

OCEL1

chr19:17338008

chr19:17330440

ENST00000215061

28_106

150

265.0

Compositional bias

Note=Pro-rich

Tgene

USE1

chr19:17338008

chr19:17330022

ENST00000263897

152_231

140

260.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

USE1

chr19:17338008

chr19:17330022

ENST00000595101

152_231

136.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

USE1

chr19:17338008

chr19:17330022

ENST00000596136

152_231

147.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

USE1

chr19:17338008

chr19:17330440

ENST00000595101

152_231

136.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

USE1

chr19:17338008

chr19:17330440

ENST00000596136

152_231

140

147.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

USE1

chr19:17338008

chr19:17330022

ENST00000263897

253_259

140

260.0

Topological domain

Lumenal

Tgene

USE1

chr19:17338008

chr19:17330022

ENST00000595101

1_231

136.0

Topological domain

Cytoplasmic

Tgene

USE1

chr19:17338008

chr19:17330022

ENST00000595101

253_259

136.0

Topological domain

Lumenal

Tgene

USE1

chr19:17338008

chr19:17330022

ENST00000596136

1_231

147.0

Topological domain

Cytoplasmic

Tgene

USE1

chr19:17338008

chr19:17330022

ENST00000596136

253_259

147.0

Topological domain

Lumenal

Tgene

USE1

chr19:17338008

chr19:17330440

ENST00000263897

253_259

199

260.0

Topological domain

Lumenal

Tgene

USE1

chr19:17338008

chr19:17330440

ENST00000595101

1_231

136.0

Topological domain

Cytoplasmic

Tgene

USE1

chr19:17338008

chr19:17330440

ENST00000595101

253_259

136.0

Topological domain

Lumenal

Tgene

USE1

chr19:17338008

chr19:17330440

ENST00000596136

253_259

140

147.0

Topological domain

Lumenal

Tgene

USE1

chr19:17338008

chr19:17330022

ENST00000263897

232_252

140

260.0

Transmembrane

Helical%3B Anchor for type IV membrane protein

Tgene

USE1

chr19:17338008

chr19:17330022

ENST00000595101

232_252

136.0

Transmembrane

Helical%3B Anchor for type IV membrane protein

Tgene

USE1

chr19:17338008

chr19:17330022

ENST00000596136

232_252

147.0

Transmembrane

Helical%3B Anchor for type IV membrane protein

Tgene

USE1

chr19:17338008

chr19:17330440

ENST00000263897

232_252

199

260.0

Transmembrane

Helical%3B Anchor for type IV membrane protein

Tgene

USE1

chr19:17338008

chr19:17330440

ENST00000595101

232_252

136.0

Transmembrane

Helical%3B Anchor for type IV membrane protein

Tgene

USE1

chr19:17338008

chr19:17330440

ENST00000596136

232_252

140

147.0

Transmembrane

Helical%3B Anchor for type IV membrane protein

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

USE1

chr19:17338008

chr19:17330440

ENST00000263897

152_231

199

260.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

USE1

chr19:17338008

chr19:17330022

ENST00000263897

1_231

140

260.0

Topological domain

Cytoplasmic

Tgene

USE1

chr19:17338008

chr19:17330440

ENST00000263897

1_231

199

260.0

Topological domain

Cytoplasmic

Tgene

USE1

chr19:17338008

chr19:17330440

ENST00000596136

1_231

140

147.0

Topological domain

Cytoplasmic

Top

Fusion Gene Sequence for OCEL1-USE1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for OCEL1-USE1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for OCEL1-USE1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for OCEL1-USE1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source