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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:OGT-POLA1 (FusionGDB2 ID:61437)

Fusion Gene Summary for OGT-POLA1

check button Fusion gene summary
Fusion gene informationFusion gene name: OGT-POLA1
Fusion gene ID: 61437
HgeneTgene
Gene symbol

OGT

POLA1

Gene ID

8473

5422

Gene nameO-linked N-acetylglucosamine (GlcNAc) transferaseDNA polymerase alpha 1, catalytic subunit
SynonymsHINCUT-1|HRNT1|MRX106|O-GLCNAC|OGT1NSX|POLA|VEODS|p180
Cytomap

Xq13.1

Xp22.11-p21.3

Type of geneprotein-codingprotein-coding
DescriptionUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitO-GlcNAc transferase p110 subunitO-GlcNAc transferase subunit p110O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyDNA polymerase alpha catalytic subunitDNA polymerase alpha catalytic subunit p180polymerase (DNA directed), alpha 1, catalytic subunitpolymerase (DNA) alpha 1, catalytic subunitpolymerase (DNA-directed), alpha (70kD)
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000498566, ENST00000373701, 
ENST00000373719, 		ENST00000379059, 
ENST00000379068, ENST00000493342, 
Fusion gene scores* DoF score9 X 9 X 4=32410 X 10 X 7=700
# samples 1012
** MAII scorelog2(10/324*10)=-1.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/700*10)=-2.54432051622381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OGT [Title/Abstract] AND POLA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointOGT(70757922)-POLA1(24828015), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOGT

GO:0006110

regulation of glycolytic process

22923583

HgeneOGT

GO:0006493

protein O-linked glycosylation

21240259|21285374|22923583|23222540|23352454|24474760

HgeneOGT

GO:0006915

apoptotic process

20824293

HgeneOGT

GO:0032868

response to insulin

18288188

HgeneOGT

GO:0035020

regulation of Rac protein signal transduction

18288188

HgeneOGT

GO:0043981

histone H4-K5 acetylation

20018852

HgeneOGT

GO:0043982

histone H4-K8 acetylation

20018852

HgeneOGT

GO:0043984

histone H4-K16 acetylation

20018852

HgeneOGT

GO:0045862

positive regulation of proteolysis

21285374

HgeneOGT

GO:0045944

positive regulation of transcription by RNA polymerase II

23222540|23353889

HgeneOGT

GO:0046626

regulation of insulin receptor signaling pathway

18288188

HgeneOGT

GO:0048015

phosphatidylinositol-mediated signaling

18288188

TgenePOLA1

GO:0006269

DNA replication, synthesis of RNA primer

2175912

TgenePOLA1

GO:0006270

DNA replication initiation

2175912

TgenePOLA1

GO:0006272

leading strand elongation

2175912|7910375

TgenePOLA1

GO:0006273

lagging strand elongation

2175912|7910375

TgenePOLA1

GO:0006281

DNA repair

3335506


check buttonFusion gene breakpoints across OGT (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across POLA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-KK-A8IC-01AOGTchrX

70757922

-POLA1chrX

24828015

+
ChimerDB4PRADTCGA-KK-A8IC-01AOGTchrX

70757922

+POLA1chrX

24828015

+
ChimerDB4PRADTCGA-KK-A8ICOGTchrX

70757922

+POLA1chrX

24828015

+


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Fusion Gene ORF analysis for OGT-POLA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000498566ENST00000379059OGTchrX

70757922

+POLA1chrX

24828015

+
3UTR-3CDSENST00000498566ENST00000379068OGTchrX

70757922

+POLA1chrX

24828015

+
3UTR-intronENST00000498566ENST00000493342OGTchrX

70757922

+POLA1chrX

24828015

+
5CDS-intronENST00000373701ENST00000493342OGTchrX

70757922

+POLA1chrX

24828015

+
5CDS-intronENST00000373719ENST00000493342OGTchrX

70757922

+POLA1chrX

24828015

+
In-frameENST00000373701ENST00000379059OGTchrX

70757922

+POLA1chrX

24828015

+
In-frameENST00000373701ENST00000379068OGTchrX

70757922

+POLA1chrX

24828015

+
In-frameENST00000373719ENST00000379059OGTchrX

70757922

+POLA1chrX

24828015

+
In-frameENST00000373719ENST00000379068OGTchrX

70757922

+POLA1chrX

24828015

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373719OGTchrX70757922+ENST00000379068POLA1chrX24828015+3158679672121684
ENST00000373719OGTchrX70757922+ENST00000379059POLA1chrX24828015+3158679672121684
ENST00000373701OGTchrX70757922+ENST00000379068POLA1chrX24828015+3088609272051674
ENST00000373701OGTchrX70757922+ENST00000379059POLA1chrX24828015+3088609272051674

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373719ENST00000379068OGTchrX70757922+POLA1chrX24828015+0.0010641850.99893576
ENST00000373719ENST00000379059OGTchrX70757922+POLA1chrX24828015+0.0010641850.99893576
ENST00000373701ENST00000379068OGTchrX70757922+POLA1chrX24828015+0.0019241510.99807584
ENST00000373701ENST00000379059OGTchrX70757922+POLA1chrX24828015+0.0019241510.99807584

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Fusion Genomic Features for OGT-POLA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
OGTchrX70757922+POLA1chrX24828014+4.27E-050.9999573
OGTchrX70757922+POLA1chrX24828014+4.27E-050.9999573
OGTchrX70757922+POLA1chrX24828014+4.27E-050.9999573
OGTchrX70757922+POLA1chrX24828014+4.27E-050.9999573

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for OGT-POLA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:70757922/chrX:24828015)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOGTchrX:70757922chrX:24828015ENST00000373701+32221_541441037.0RepeatNote=TPR 1
HgeneOGTchrX:70757922chrX:24828015ENST00000373701+32289_1221441037.0RepeatNote=TPR 2
HgeneOGTchrX:70757922chrX:24828015ENST00000373719+322123_1561541047.0RepeatNote=TPR 3
HgeneOGTchrX:70757922chrX:24828015ENST00000373719+32221_541541047.0RepeatNote=TPR 1
HgeneOGTchrX:70757922chrX:24828015ENST00000373719+32289_1221541047.0RepeatNote=TPR 2
TgenePOLA1chrX:70757922chrX:24828015ENST0000037905925371047_10509821463.0Compositional biasNote=Poly-Leu
TgenePOLA1chrX:70757922chrX:24828015ENST0000037905925371051_10549821463.0Compositional biasNote=Poly-Lys
TgenePOLA1chrX:70757922chrX:24828015ENST0000037905925371348_13749821463.0MotifCysB motif
TgenePOLA1chrX:70757922chrX:24828015ENST0000037905925371245_13769821463.0RegionDNA-binding
TgenePOLA1chrX:70757922chrX:24828015ENST0000037905925371283_13189821463.0Zinc fingerCysA-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOGTchrX:70757922chrX:24828015ENST00000373701+322487_5031441037.0MotifNuclear localization signal
HgeneOGTchrX:70757922chrX:24828015ENST00000373719+322487_5031541047.0MotifNuclear localization signal
HgeneOGTchrX:70757922chrX:24828015ENST00000373701+322906_9081441037.0Nucleotide bindingUDP
HgeneOGTchrX:70757922chrX:24828015ENST00000373701+322911_9141441037.0Nucleotide bindingUDP
HgeneOGTchrX:70757922chrX:24828015ENST00000373701+322930_9321441037.0Nucleotide bindingUDP
HgeneOGTchrX:70757922chrX:24828015ENST00000373719+322906_9081541047.0Nucleotide bindingUDP
HgeneOGTchrX:70757922chrX:24828015ENST00000373719+322911_9141541047.0Nucleotide bindingUDP
HgeneOGTchrX:70757922chrX:24828015ENST00000373719+322930_9321541047.0Nucleotide bindingUDP
HgeneOGTchrX:70757922chrX:24828015ENST00000373701+322991_10101441037.0RegionNote=Required for phosphatidylinositol 3%2C4%2C5-triphosphate binding
HgeneOGTchrX:70757922chrX:24828015ENST00000373719+322991_10101541047.0RegionNote=Required for phosphatidylinositol 3%2C4%2C5-triphosphate binding
HgeneOGTchrX:70757922chrX:24828015ENST00000373701+322123_1561441037.0RepeatNote=TPR 3
HgeneOGTchrX:70757922chrX:24828015ENST00000373701+322157_1901441037.0RepeatNote=TPR 4
HgeneOGTchrX:70757922chrX:24828015ENST00000373701+322191_2241441037.0RepeatNote=TPR 5
HgeneOGTchrX:70757922chrX:24828015ENST00000373701+322225_2581441037.0RepeatNote=TPR 6
HgeneOGTchrX:70757922chrX:24828015ENST00000373701+322259_2921441037.0RepeatNote=TPR 7
HgeneOGTchrX:70757922chrX:24828015ENST00000373701+322293_3261441037.0RepeatNote=TPR 8
HgeneOGTchrX:70757922chrX:24828015ENST00000373701+322327_3601441037.0RepeatNote=TPR 9
HgeneOGTchrX:70757922chrX:24828015ENST00000373701+322361_3941441037.0RepeatNote=TPR 10
HgeneOGTchrX:70757922chrX:24828015ENST00000373701+322395_4281441037.0RepeatNote=TPR 11
HgeneOGTchrX:70757922chrX:24828015ENST00000373701+322429_4621441037.0RepeatNote=TPR 12
HgeneOGTchrX:70757922chrX:24828015ENST00000373701+322463_4731441037.0RepeatNote=TPR 13%3B truncated
HgeneOGTchrX:70757922chrX:24828015ENST00000373719+322157_1901541047.0RepeatNote=TPR 4
HgeneOGTchrX:70757922chrX:24828015ENST00000373719+322191_2241541047.0RepeatNote=TPR 5
HgeneOGTchrX:70757922chrX:24828015ENST00000373719+322225_2581541047.0RepeatNote=TPR 6
HgeneOGTchrX:70757922chrX:24828015ENST00000373719+322259_2921541047.0RepeatNote=TPR 7
HgeneOGTchrX:70757922chrX:24828015ENST00000373719+322293_3261541047.0RepeatNote=TPR 8
HgeneOGTchrX:70757922chrX:24828015ENST00000373719+322327_3601541047.0RepeatNote=TPR 9
HgeneOGTchrX:70757922chrX:24828015ENST00000373719+322361_3941541047.0RepeatNote=TPR 10
HgeneOGTchrX:70757922chrX:24828015ENST00000373719+322395_4281541047.0RepeatNote=TPR 11
HgeneOGTchrX:70757922chrX:24828015ENST00000373719+322429_4621541047.0RepeatNote=TPR 12
HgeneOGTchrX:70757922chrX:24828015ENST00000373719+322463_4731541047.0RepeatNote=TPR 13%3B truncated
TgenePOLA1chrX:70757922chrX:24828015ENST00000379059253775_1129821463.0Compositional biasNote=Asp-rich
TgenePOLA1chrX:70757922chrX:24828015ENST000003790592537650_7159821463.0RegionDNA-binding


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Fusion Gene Sequence for OGT-POLA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>61437_61437_1_OGT-POLA1_OGT_chrX_70757922_ENST00000373701_POLA1_chrX_24828015_ENST00000379059_length(transcript)=3088nt_BP=609nt
TAGATGGTCAATTAGAGTTCCCAGGGTTTGAAGCCTGTAACTGCTGCCGCCGCTCAAGCCCTCCAGAGCATTGCTACGGCTGCTGCCCTT
GTACTACTACCTCCAAATACGTTCTTGCTGGTAGTGGCGGCAGCAGGACCAATTACCTCTTTTTTGCTCTCCCTCGAGAAGCTCCAGATG
GCGTCTTCCGTGGGCAACGTGGCCGACAGCACAGGGTTAGCTGAGTTGGCACATCGAGAATATCAGGCAGGAGATTTTGAGGCAGCTGAG
AGACACTGCATGCAGCTCTGGAGACAAGAGCCAGACAATACTGGTGTGCTTTTATTACTTTCATCTATACACTTCCAGTGTCGAAGGCTG
GACAGATCTGCTCACTTTAGCACTCTGGCAATTAAACAGAACCCCCTTCTGGCAGAAGCTTATTCGAATTTGGGGAATGTGTACAAGGAA
AGAGGGCAGTTGCAGGAGGCAATTGAGCATTATCGACATGCATTGCGTCTCAAACCTGATTTCATCGATGGTTATATTAACCTGGCAGCC
GCCTTGGTAGCAGCGGGTGACATGGAAGGGGCAGTACAAGCTTACGTCTCTGCTCTTCAGTACAATCCTATTTTGATGCATACGAAAGAG
ATGGTACAAAAGATGAATCTTGAAGTTATTTATGGAGATACAGATTCAATTATGATAAACACCAATAGCACCAATCTGGAAGAAGTATTT
AAGTTGGGAAACAAGGTAAAAAGTGAAGTGAATAAGTTGTACAAACTGCTTGAAATAGACATTGATGGGGTTTTCAAGTCTCTGCTACTG
CTGAAAAAAAAGAAGTACGCTGCTCTGGTTGTTGAGCCAACGTCGGATGGGAATTATGTCACCAAACAGGAGCTCAAAGGATTAGATATA
GTTAGAAGAGATTGGTGTGATCTTGCTAAAGACACTGGAAACTTTGTGATTGGCCAGATTCTTTCTGATCAAAGCCGGGACACTATAGTG
GAAAACATTCAGAAGAGGCTGATAGAAATTGGAGAAAATGTGCTAAATGGCAGTGTCCCAGTGAGCCAGTTTGAAATTAACAAGGCATTG
ACAAAGGATCCCCAGGATTACCCTGATAAAAAAAGCCTACCTCATGTACATGTTGCCCTCTGGATAAATTCTCAAGGAGGCAGAAAGGTG
AAAGCTGGAGATACTGTGTCATATGTCATCTGTCAGGATGGATCAAACCTCACTGCAAGTCAGAGGGCCTATGCGCCTGAGCAGCTGCAG
AAACAGGATAATCTAACCATTGACACCCAGTACTACCTGGCCCAGCAGATCCACCCAGTCGTGGCTCGGATCTGTGAACCAATAGACGGA
ATTGATGCTGTCCTCATTGCAACGTGGTTGGGACTTGACCCCACCCAATTTAGAGTTCATCATTATCATAAAGATGAAGAGAATGATGCT
CTACTTGGTGGCCCAGCACAGCTCACTGATGAAGAGAAATACAGGGACTGTGAAAGATTCAAATGTCCATGCCCTACATGTGGAACTGAG
AATATTTATGATAATGTCTTTGATGGTTCGGGAACAGATATGGAGCCCAGCTTGTATCGTTGCAGTAACATCGATTGTAAGGCTTCACCT
CTGACCTTTACAGTACAACTGAGCAACAAATTGATCATGGACATTAGACGTTTCATTAAAAAGTACTATGATGGCTGGTTGATATGTGAA
GAGCCAACCTGTCGCAATCGAACTCGTCACCTTCCCCTTCAATTCTCCCGAACTGGGCCTCTTTGCCCAGCCTGCATGAAAGCTACACTT
CAACCAGAGTATTCTGACAAGTCCCTGTACACCCAGCTGTGCTTTTACCGGTACATTTTTGATGCGGAGTGTGCACTGGAGAAACTTACT
ACCGATCATGAGAAAGATAAATTGAAGAAGCAATTTTTTACCCCCAAAGTTCTGCAGGACTACAGAAAACTCAAGAACACAGCAGAGCAA
TTCTTGTCCCGAAGTGGCTACTCCGAAGTGAATCTGAGCAAACTCTTCGCTGGTTGTGCCGTGAAATCCTAAGGGAATCCCAGGAGTAAC
CAAGGAGGGGGTAGTTGAAAAATCCCAGCTTCCTCTGTGCCTCCACTCTGGCCCTAAATGCTCCTCCAGCATCTGTTTCTCCCTTGGGAC
TGTGTCTCATGTTTGTGTGAATGTAGACCAGGAAAGGGGGCTGCAAAAATGTTGAGTCTAATGTTCGTAAGCATCATAGAAATTCCTGTC
TTCATATTAAGATGTACTGCTTTAAAACACAACTCCAGAGCCCCTCCCCAAGCTCCCCTCCCCAAGCTCCTGAAGACCCGGTTTCTGAGG
GAGGGAAATTGCTACTTGGATTGAGAGTAGCTGGAATGTAAGTGACCCCAGGCTTTGCCTCAGGGCCTTTAGCCTATGTCCCCCCCACAT
AAAGAGAGCTTCTCAGAGCCTGACTGAAGAGCTGACGTTTTGCTTTTTCATATGCCAATTAAACCCGGTCTAAATCCAAATGCTTCTCCA
GCCATCCAGGAGTGGCTGTCCTTTTCAGTCTTGTCTTTTATATAGGTAGCTGAGGGGGAAGATTTAGAAGCCTTGCACTCACTAAATAGA
TTAAACAGAGCAGGCTTGTTTGTTGAATTGCTCCAAAGTCCAACAGACACACACTGAGCAGGTGTTTTACACTCACATTCCCTTTTTGCC
CCTTAAATAGAAAGTGCAGGTAAAGGTTTATACAACAAGAAAGCACATTGAAAATAATTTGATACTCTAACAATCCATTAACATGTGTAG
GGGTTACGGTGAGGATCACTGTGTTGTATTCAGAAAAACGGGGAGAGGGATGCTTAATTGGCCCTGGCGCTTGCTATTTTTTTCTCATTT
CTTCACAATAGGACCGTCTTTGGCAGCAGCAAAATGTATTTCAGTATGGCAGTCTTTCCTCTCTTACATTATTGGTAAGATTATACTAAC
AAAATGTTTCCCCTTGTACAATTATGCTGTGTTTTTAAAAAACATTGACCTGTGTGTTTTTATAAAAGAAAAAGTATGTTGTGCCTTCTT

>61437_61437_1_OGT-POLA1_OGT_chrX_70757922_ENST00000373701_POLA1_chrX_24828015_ENST00000379059_length(amino acids)=674AA_BP=194
MKPVTAAAAQALQSIATAAALVLLPPNTFLLVVAAAGPITSFLLSLEKLQMASSVGNVADSTGLAELAHREYQAGDFEAAERHCMQLWRQ
EPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME
GAVQAYVSALQYNPILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKLLEIDIDGVFKSLLLLKKKKYAAL
VVEPTSDGNYVTKQELKGLDIVRRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKDPQDYPD
KKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVLIATW
LGLDPTQFRVHHYHKDEENDALLGGPAQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKASPLTFTVQLSN
KLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQPEYSDKSLYTQLCFYRYIFDAECALEKLTTDHEKDKLK

--------------------------------------------------------------
>61437_61437_2_OGT-POLA1_OGT_chrX_70757922_ENST00000373701_POLA1_chrX_24828015_ENST00000379068_length(transcript)=3088nt_BP=609nt
TAGATGGTCAATTAGAGTTCCCAGGGTTTGAAGCCTGTAACTGCTGCCGCCGCTCAAGCCCTCCAGAGCATTGCTACGGCTGCTGCCCTT
GTACTACTACCTCCAAATACGTTCTTGCTGGTAGTGGCGGCAGCAGGACCAATTACCTCTTTTTTGCTCTCCCTCGAGAAGCTCCAGATG
GCGTCTTCCGTGGGCAACGTGGCCGACAGCACAGGGTTAGCTGAGTTGGCACATCGAGAATATCAGGCAGGAGATTTTGAGGCAGCTGAG
AGACACTGCATGCAGCTCTGGAGACAAGAGCCAGACAATACTGGTGTGCTTTTATTACTTTCATCTATACACTTCCAGTGTCGAAGGCTG
GACAGATCTGCTCACTTTAGCACTCTGGCAATTAAACAGAACCCCCTTCTGGCAGAAGCTTATTCGAATTTGGGGAATGTGTACAAGGAA
AGAGGGCAGTTGCAGGAGGCAATTGAGCATTATCGACATGCATTGCGTCTCAAACCTGATTTCATCGATGGTTATATTAACCTGGCAGCC
GCCTTGGTAGCAGCGGGTGACATGGAAGGGGCAGTACAAGCTTACGTCTCTGCTCTTCAGTACAATCCTATTTTGATGCATACGAAAGAG
ATGGTACAAAAGATGAATCTTGAAGTTATTTATGGAGATACAGATTCAATTATGATAAACACCAATAGCACCAATCTGGAAGAAGTATTT
AAGTTGGGAAACAAGGTAAAAAGTGAAGTGAATAAGTTGTACAAACTGCTTGAAATAGACATTGATGGGGTTTTCAAGTCTCTGCTACTG
CTGAAAAAAAAGAAGTACGCTGCTCTGGTTGTTGAGCCAACGTCGGATGGGAATTATGTCACCAAACAGGAGCTCAAAGGATTAGATATA
GTTAGAAGAGATTGGTGTGATCTTGCTAAAGACACTGGAAACTTTGTGATTGGCCAGATTCTTTCTGATCAAAGCCGGGACACTATAGTG
GAAAACATTCAGAAGAGGCTGATAGAAATTGGAGAAAATGTGCTAAATGGCAGTGTCCCAGTGAGCCAGTTTGAAATTAACAAGGCATTG
ACAAAGGATCCCCAGGATTACCCTGATAAAAAAAGCCTACCTCATGTACATGTTGCCCTCTGGATAAATTCTCAAGGAGGCAGAAAGGTG
AAAGCTGGAGATACTGTGTCATATGTCATCTGTCAGGATGGATCAAACCTCACTGCAAGTCAGAGGGCCTATGCGCCTGAGCAGCTGCAG
AAACAGGATAATCTAACCATTGACACCCAGTACTACCTGGCCCAGCAGATCCACCCAGTCGTGGCTCGGATCTGTGAACCAATAGACGGA
ATTGATGCTGTCCTCATTGCAACGTGGTTGGGACTTGACCCCACCCAATTTAGAGTTCATCATTATCATAAAGATGAAGAGAATGATGCT
CTACTTGGTGGCCCAGCACAGCTCACTGATGAAGAGAAATACAGGGACTGTGAAAGATTCAAATGTCCATGCCCTACATGTGGAACTGAG
AATATTTATGATAATGTCTTTGATGGTTCGGGAACAGATATGGAGCCCAGCTTGTATCGTTGCAGTAACATCGATTGTAAGGCTTCACCT
CTGACCTTTACAGTACAACTGAGCAACAAATTGATCATGGACATTAGACGTTTCATTAAAAAGTACTATGATGGCTGGTTGATATGTGAA
GAGCCAACCTGTCGCAATCGAACTCGTCACCTTCCCCTTCAATTCTCCCGAACTGGGCCTCTTTGCCCAGCCTGCATGAAAGCTACACTT
CAACCAGAGTATTCTGACAAGTCCCTGTACACCCAGCTGTGCTTTTACCGGTACATTTTTGATGCGGAGTGTGCACTGGAGAAACTTACT
ACCGATCATGAGAAAGATAAATTGAAGAAGCAATTTTTTACCCCCAAAGTTCTGCAGGACTACAGAAAACTCAAGAACACAGCAGAGCAA
TTCTTGTCCCGAAGTGGCTACTCCGAAGTGAATCTGAGCAAACTCTTCGCTGGTTGTGCCGTGAAATCCTAAGGGAATCCCAGGAGTAAC
CAAGGAGGGGGTAGTTGAAAAATCCCAGCTTCCTCTGTGCCTCCACTCTGGCCCTAAATGCTCCTCCAGCATCTGTTTCTCCCTTGGGAC
TGTGTCTCATGTTTGTGTGAATGTAGACCAGGAAAGGGGGCTGCAAAAATGTTGAGTCTAATGTTCGTAAGCATCATAGAAATTCCTGTC
TTCATATTAAGATGTACTGCTTTAAAACACAACTCCAGAGCCCCTCCCCAAGCTCCCCTCCCCAAGCTCCTGAAGACCCGGTTTCTGAGG
GAGGGAAATTGCTACTTGGATTGAGAGTAGCTGGAATGTAAGTGACCCCAGGCTTTGCCTCAGGGCCTTTAGCCTATGTCCCCCCCACAT
AAAGAGAGCTTCTCAGAGCCTGACTGAAGAGCTGACGTTTTGCTTTTTCATATGCCAATTAAACCCGGTCTAAATCCAAATGCTTCTCCA
GCCATCCAGGAGTGGCTGTCCTTTTCAGTCTTGTCTTTTATATAGGTAGCTGAGGGGGAAGATTTAGAAGCCTTGCACTCACTAAATAGA
TTAAACAGAGCAGGCTTGTTTGTTGAATTGCTCCAAAGTCCAACAGACACACACTGAGCAGGTGTTTTACACTCACATTCCCTTTTTGCC
CCTTAAATAGAAAGTGCAGGTAAAGGTTTATACAACAAGAAAGCACATTGAAAATAATTTGATACTCTAACAATCCATTAACATGTGTAG
GGGTTACGGTGAGGATCACTGTGTTGTATTCAGAAAAACGGGGAGAGGGATGCTTAATTGGCCCTGGCGCTTGCTATTTTTTTCTCATTT
CTTCACAATAGGACCGTCTTTGGCAGCAGCAAAATGTATTTCAGTATGGCAGTCTTTCCTCTCTTACATTATTGGTAAGATTATACTAAC
AAAATGTTTCCCCTTGTACAATTATGCTGTGTTTTTAAAAAACATTGACCTGTGTGTTTTTATAAAAGAAAAAGTATGTTGTGCCTTCTT

>61437_61437_2_OGT-POLA1_OGT_chrX_70757922_ENST00000373701_POLA1_chrX_24828015_ENST00000379068_length(amino acids)=674AA_BP=194
MKPVTAAAAQALQSIATAAALVLLPPNTFLLVVAAAGPITSFLLSLEKLQMASSVGNVADSTGLAELAHREYQAGDFEAAERHCMQLWRQ
EPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME
GAVQAYVSALQYNPILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKLLEIDIDGVFKSLLLLKKKKYAAL
VVEPTSDGNYVTKQELKGLDIVRRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKDPQDYPD
KKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVLIATW
LGLDPTQFRVHHYHKDEENDALLGGPAQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKASPLTFTVQLSN
KLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQPEYSDKSLYTQLCFYRYIFDAECALEKLTTDHEKDKLK

--------------------------------------------------------------
>61437_61437_3_OGT-POLA1_OGT_chrX_70757922_ENST00000373719_POLA1_chrX_24828015_ENST00000379059_length(transcript)=3158nt_BP=679nt
GGCCGAGGAGCCGTCGCCGCCATTTCAAGACCGTACTAGGTAGATGGTCAATTAGAGTTCCCAGGGTTTGAAGCCTGTAACTGCTGCCGC
CGCTCAAGCCCTCCAGAGCATTGCTACGGCTGCTGCCCTTGTACTACTACCTCCAAATACGTTCTTGCTGGTAGTGGCGGCAGCAGGACC
AATTACCTCTTTTTTGCTCTCCCTCGAGAAGCTCCAGATGGCGTCTTCCGTGGGCAACGTGGCCGACAGCACAGAACCAACGAAACGTAT
GCTTTCCTTCCAAGGGTTAGCTGAGTTGGCACATCGAGAATATCAGGCAGGAGATTTTGAGGCAGCTGAGAGACACTGCATGCAGCTCTG
GAGACAAGAGCCAGACAATACTGGTGTGCTTTTATTACTTTCATCTATACACTTCCAGTGTCGAAGGCTGGACAGATCTGCTCACTTTAG
CACTCTGGCAATTAAACAGAACCCCCTTCTGGCAGAAGCTTATTCGAATTTGGGGAATGTGTACAAGGAAAGAGGGCAGTTGCAGGAGGC
AATTGAGCATTATCGACATGCATTGCGTCTCAAACCTGATTTCATCGATGGTTATATTAACCTGGCAGCCGCCTTGGTAGCAGCGGGTGA
CATGGAAGGGGCAGTACAAGCTTACGTCTCTGCTCTTCAGTACAATCCTATTTTGATGCATACGAAAGAGATGGTACAAAAGATGAATCT
TGAAGTTATTTATGGAGATACAGATTCAATTATGATAAACACCAATAGCACCAATCTGGAAGAAGTATTTAAGTTGGGAAACAAGGTAAA
AAGTGAAGTGAATAAGTTGTACAAACTGCTTGAAATAGACATTGATGGGGTTTTCAAGTCTCTGCTACTGCTGAAAAAAAAGAAGTACGC
TGCTCTGGTTGTTGAGCCAACGTCGGATGGGAATTATGTCACCAAACAGGAGCTCAAAGGATTAGATATAGTTAGAAGAGATTGGTGTGA
TCTTGCTAAAGACACTGGAAACTTTGTGATTGGCCAGATTCTTTCTGATCAAAGCCGGGACACTATAGTGGAAAACATTCAGAAGAGGCT
GATAGAAATTGGAGAAAATGTGCTAAATGGCAGTGTCCCAGTGAGCCAGTTTGAAATTAACAAGGCATTGACAAAGGATCCCCAGGATTA
CCCTGATAAAAAAAGCCTACCTCATGTACATGTTGCCCTCTGGATAAATTCTCAAGGAGGCAGAAAGGTGAAAGCTGGAGATACTGTGTC
ATATGTCATCTGTCAGGATGGATCAAACCTCACTGCAAGTCAGAGGGCCTATGCGCCTGAGCAGCTGCAGAAACAGGATAATCTAACCAT
TGACACCCAGTACTACCTGGCCCAGCAGATCCACCCAGTCGTGGCTCGGATCTGTGAACCAATAGACGGAATTGATGCTGTCCTCATTGC
AACGTGGTTGGGACTTGACCCCACCCAATTTAGAGTTCATCATTATCATAAAGATGAAGAGAATGATGCTCTACTTGGTGGCCCAGCACA
GCTCACTGATGAAGAGAAATACAGGGACTGTGAAAGATTCAAATGTCCATGCCCTACATGTGGAACTGAGAATATTTATGATAATGTCTT
TGATGGTTCGGGAACAGATATGGAGCCCAGCTTGTATCGTTGCAGTAACATCGATTGTAAGGCTTCACCTCTGACCTTTACAGTACAACT
GAGCAACAAATTGATCATGGACATTAGACGTTTCATTAAAAAGTACTATGATGGCTGGTTGATATGTGAAGAGCCAACCTGTCGCAATCG
AACTCGTCACCTTCCCCTTCAATTCTCCCGAACTGGGCCTCTTTGCCCAGCCTGCATGAAAGCTACACTTCAACCAGAGTATTCTGACAA
GTCCCTGTACACCCAGCTGTGCTTTTACCGGTACATTTTTGATGCGGAGTGTGCACTGGAGAAACTTACTACCGATCATGAGAAAGATAA
ATTGAAGAAGCAATTTTTTACCCCCAAAGTTCTGCAGGACTACAGAAAACTCAAGAACACAGCAGAGCAATTCTTGTCCCGAAGTGGCTA
CTCCGAAGTGAATCTGAGCAAACTCTTCGCTGGTTGTGCCGTGAAATCCTAAGGGAATCCCAGGAGTAACCAAGGAGGGGGTAGTTGAAA
AATCCCAGCTTCCTCTGTGCCTCCACTCTGGCCCTAAATGCTCCTCCAGCATCTGTTTCTCCCTTGGGACTGTGTCTCATGTTTGTGTGA
ATGTAGACCAGGAAAGGGGGCTGCAAAAATGTTGAGTCTAATGTTCGTAAGCATCATAGAAATTCCTGTCTTCATATTAAGATGTACTGC
TTTAAAACACAACTCCAGAGCCCCTCCCCAAGCTCCCCTCCCCAAGCTCCTGAAGACCCGGTTTCTGAGGGAGGGAAATTGCTACTTGGA
TTGAGAGTAGCTGGAATGTAAGTGACCCCAGGCTTTGCCTCAGGGCCTTTAGCCTATGTCCCCCCCACATAAAGAGAGCTTCTCAGAGCC
TGACTGAAGAGCTGACGTTTTGCTTTTTCATATGCCAATTAAACCCGGTCTAAATCCAAATGCTTCTCCAGCCATCCAGGAGTGGCTGTC
CTTTTCAGTCTTGTCTTTTATATAGGTAGCTGAGGGGGAAGATTTAGAAGCCTTGCACTCACTAAATAGATTAAACAGAGCAGGCTTGTT
TGTTGAATTGCTCCAAAGTCCAACAGACACACACTGAGCAGGTGTTTTACACTCACATTCCCTTTTTGCCCCTTAAATAGAAAGTGCAGG
TAAAGGTTTATACAACAAGAAAGCACATTGAAAATAATTTGATACTCTAACAATCCATTAACATGTGTAGGGGTTACGGTGAGGATCACT
GTGTTGTATTCAGAAAAACGGGGAGAGGGATGCTTAATTGGCCCTGGCGCTTGCTATTTTTTTCTCATTTCTTCACAATAGGACCGTCTT
TGGCAGCAGCAAAATGTATTTCAGTATGGCAGTCTTTCCTCTCTTACATTATTGGTAAGATTATACTAACAAAATGTTTCCCCTTGTACA
ATTATGCTGTGTTTTTAAAAAACATTGACCTGTGTGTTTTTATAAAAGAAAAAGTATGTTGTGCCTTCTTCTTAAGAATAAAGTTTTCTA

>61437_61437_3_OGT-POLA1_OGT_chrX_70757922_ENST00000373719_POLA1_chrX_24828015_ENST00000379059_length(amino acids)=684AA_BP=204
MKPVTAAAAQALQSIATAAALVLLPPNTFLLVVAAAGPITSFLLSLEKLQMASSVGNVADSTEPTKRMLSFQGLAELAHREYQAGDFEAA
ERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLA
AALVAAGDMEGAVQAYVSALQYNPILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKLLEIDIDGVFKSLL
LLKKKKYAALVVEPTSDGNYVTKQELKGLDIVRRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKA
LTKDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEPID
GIDAVLIATWLGLDPTQFRVHHYHKDEENDALLGGPAQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKAS
PLTFTVQLSNKLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQPEYSDKSLYTQLCFYRYIFDAECALEKL

--------------------------------------------------------------
>61437_61437_4_OGT-POLA1_OGT_chrX_70757922_ENST00000373719_POLA1_chrX_24828015_ENST00000379068_length(transcript)=3158nt_BP=679nt
GGCCGAGGAGCCGTCGCCGCCATTTCAAGACCGTACTAGGTAGATGGTCAATTAGAGTTCCCAGGGTTTGAAGCCTGTAACTGCTGCCGC
CGCTCAAGCCCTCCAGAGCATTGCTACGGCTGCTGCCCTTGTACTACTACCTCCAAATACGTTCTTGCTGGTAGTGGCGGCAGCAGGACC
AATTACCTCTTTTTTGCTCTCCCTCGAGAAGCTCCAGATGGCGTCTTCCGTGGGCAACGTGGCCGACAGCACAGAACCAACGAAACGTAT
GCTTTCCTTCCAAGGGTTAGCTGAGTTGGCACATCGAGAATATCAGGCAGGAGATTTTGAGGCAGCTGAGAGACACTGCATGCAGCTCTG
GAGACAAGAGCCAGACAATACTGGTGTGCTTTTATTACTTTCATCTATACACTTCCAGTGTCGAAGGCTGGACAGATCTGCTCACTTTAG
CACTCTGGCAATTAAACAGAACCCCCTTCTGGCAGAAGCTTATTCGAATTTGGGGAATGTGTACAAGGAAAGAGGGCAGTTGCAGGAGGC
AATTGAGCATTATCGACATGCATTGCGTCTCAAACCTGATTTCATCGATGGTTATATTAACCTGGCAGCCGCCTTGGTAGCAGCGGGTGA
CATGGAAGGGGCAGTACAAGCTTACGTCTCTGCTCTTCAGTACAATCCTATTTTGATGCATACGAAAGAGATGGTACAAAAGATGAATCT
TGAAGTTATTTATGGAGATACAGATTCAATTATGATAAACACCAATAGCACCAATCTGGAAGAAGTATTTAAGTTGGGAAACAAGGTAAA
AAGTGAAGTGAATAAGTTGTACAAACTGCTTGAAATAGACATTGATGGGGTTTTCAAGTCTCTGCTACTGCTGAAAAAAAAGAAGTACGC
TGCTCTGGTTGTTGAGCCAACGTCGGATGGGAATTATGTCACCAAACAGGAGCTCAAAGGATTAGATATAGTTAGAAGAGATTGGTGTGA
TCTTGCTAAAGACACTGGAAACTTTGTGATTGGCCAGATTCTTTCTGATCAAAGCCGGGACACTATAGTGGAAAACATTCAGAAGAGGCT
GATAGAAATTGGAGAAAATGTGCTAAATGGCAGTGTCCCAGTGAGCCAGTTTGAAATTAACAAGGCATTGACAAAGGATCCCCAGGATTA
CCCTGATAAAAAAAGCCTACCTCATGTACATGTTGCCCTCTGGATAAATTCTCAAGGAGGCAGAAAGGTGAAAGCTGGAGATACTGTGTC
ATATGTCATCTGTCAGGATGGATCAAACCTCACTGCAAGTCAGAGGGCCTATGCGCCTGAGCAGCTGCAGAAACAGGATAATCTAACCAT
TGACACCCAGTACTACCTGGCCCAGCAGATCCACCCAGTCGTGGCTCGGATCTGTGAACCAATAGACGGAATTGATGCTGTCCTCATTGC
AACGTGGTTGGGACTTGACCCCACCCAATTTAGAGTTCATCATTATCATAAAGATGAAGAGAATGATGCTCTACTTGGTGGCCCAGCACA
GCTCACTGATGAAGAGAAATACAGGGACTGTGAAAGATTCAAATGTCCATGCCCTACATGTGGAACTGAGAATATTTATGATAATGTCTT
TGATGGTTCGGGAACAGATATGGAGCCCAGCTTGTATCGTTGCAGTAACATCGATTGTAAGGCTTCACCTCTGACCTTTACAGTACAACT
GAGCAACAAATTGATCATGGACATTAGACGTTTCATTAAAAAGTACTATGATGGCTGGTTGATATGTGAAGAGCCAACCTGTCGCAATCG
AACTCGTCACCTTCCCCTTCAATTCTCCCGAACTGGGCCTCTTTGCCCAGCCTGCATGAAAGCTACACTTCAACCAGAGTATTCTGACAA
GTCCCTGTACACCCAGCTGTGCTTTTACCGGTACATTTTTGATGCGGAGTGTGCACTGGAGAAACTTACTACCGATCATGAGAAAGATAA
ATTGAAGAAGCAATTTTTTACCCCCAAAGTTCTGCAGGACTACAGAAAACTCAAGAACACAGCAGAGCAATTCTTGTCCCGAAGTGGCTA
CTCCGAAGTGAATCTGAGCAAACTCTTCGCTGGTTGTGCCGTGAAATCCTAAGGGAATCCCAGGAGTAACCAAGGAGGGGGTAGTTGAAA
AATCCCAGCTTCCTCTGTGCCTCCACTCTGGCCCTAAATGCTCCTCCAGCATCTGTTTCTCCCTTGGGACTGTGTCTCATGTTTGTGTGA
ATGTAGACCAGGAAAGGGGGCTGCAAAAATGTTGAGTCTAATGTTCGTAAGCATCATAGAAATTCCTGTCTTCATATTAAGATGTACTGC
TTTAAAACACAACTCCAGAGCCCCTCCCCAAGCTCCCCTCCCCAAGCTCCTGAAGACCCGGTTTCTGAGGGAGGGAAATTGCTACTTGGA
TTGAGAGTAGCTGGAATGTAAGTGACCCCAGGCTTTGCCTCAGGGCCTTTAGCCTATGTCCCCCCCACATAAAGAGAGCTTCTCAGAGCC
TGACTGAAGAGCTGACGTTTTGCTTTTTCATATGCCAATTAAACCCGGTCTAAATCCAAATGCTTCTCCAGCCATCCAGGAGTGGCTGTC
CTTTTCAGTCTTGTCTTTTATATAGGTAGCTGAGGGGGAAGATTTAGAAGCCTTGCACTCACTAAATAGATTAAACAGAGCAGGCTTGTT
TGTTGAATTGCTCCAAAGTCCAACAGACACACACTGAGCAGGTGTTTTACACTCACATTCCCTTTTTGCCCCTTAAATAGAAAGTGCAGG
TAAAGGTTTATACAACAAGAAAGCACATTGAAAATAATTTGATACTCTAACAATCCATTAACATGTGTAGGGGTTACGGTGAGGATCACT
GTGTTGTATTCAGAAAAACGGGGAGAGGGATGCTTAATTGGCCCTGGCGCTTGCTATTTTTTTCTCATTTCTTCACAATAGGACCGTCTT
TGGCAGCAGCAAAATGTATTTCAGTATGGCAGTCTTTCCTCTCTTACATTATTGGTAAGATTATACTAACAAAATGTTTCCCCTTGTACA
ATTATGCTGTGTTTTTAAAAAACATTGACCTGTGTGTTTTTATAAAAGAAAAAGTATGTTGTGCCTTCTTCTTAAGAATAAAGTTTTCTA

>61437_61437_4_OGT-POLA1_OGT_chrX_70757922_ENST00000373719_POLA1_chrX_24828015_ENST00000379068_length(amino acids)=684AA_BP=204
MKPVTAAAAQALQSIATAAALVLLPPNTFLLVVAAAGPITSFLLSLEKLQMASSVGNVADSTEPTKRMLSFQGLAELAHREYQAGDFEAA
ERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLA
AALVAAGDMEGAVQAYVSALQYNPILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKLLEIDIDGVFKSLL
LLKKKKYAALVVEPTSDGNYVTKQELKGLDIVRRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKA
LTKDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEPID
GIDAVLIATWLGLDPTQFRVHHYHKDEENDALLGGPAQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKAS
PLTFTVQLSNKLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQPEYSDKSLYTQLCFYRYIFDAECALEKL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for OGT-POLA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for OGT-POLA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for OGT-POLA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource