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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:OLA1-PDE11A (FusionGDB2 ID:61461)

Fusion Gene Summary for OLA1-PDE11A

check button Fusion gene summary
Fusion gene informationFusion gene name: OLA1-PDE11A
Fusion gene ID: 61461
HgeneTgene
Gene symbol

OLA1

PDE11A

Gene ID

29789

50940

Gene nameObg like ATPase 1phosphodiesterase 11A
SynonymsDOC45|GBP45|GTBP9|GTPBP9|PTD004PPNAD2
Cytomap

2q31.1

2q31.2

Type of geneprotein-codingprotein-coding
Descriptionobg-like ATPase 1DNA damage-regulated overexpressed in cancer 45 proteinGTP-binding protein 9 (putative)GTP-binding protein PTD004homologous yeast-44.2 proteindual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11AcAMP and cGMP cyclic nucleotide phosphodiesterase 11A
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000284719, ENST00000409546, 
ENST00000428402, ENST00000344357, 
ENST00000392560, 		ENST00000497003, 
ENST00000389683, ENST00000409504, 
ENST00000449286, ENST00000450799, 
ENST00000286063, ENST00000358450, 
Fusion gene scores* DoF score10 X 5 X 8=4008 X 5 X 6=240
# samples 1211
** MAII scorelog2(12/400*10)=-1.73696559416621
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/240*10)=-1.12553088208386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OLA1 [Title/Abstract] AND PDE11A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointOLA1(175087761)-PDE11A(178592900), # samples:1
Anticipated loss of major functional domain due to fusion event.OLA1-PDE11A seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
OLA1-PDE11A seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOLA1

GO:0046034

ATP metabolic process

17430889


check buttonFusion gene breakpoints across OLA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PDE11A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-75-6211-01AOLA1chr2

175087761

-PDE11Achr2

178592900

-


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Fusion Gene ORF analysis for OLA1-PDE11A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000284719ENST00000497003OLA1chr2

175087761

-PDE11Achr2

178592900

-
5CDS-5UTRENST00000409546ENST00000497003OLA1chr2

175087761

-PDE11Achr2

178592900

-
5CDS-5UTRENST00000428402ENST00000497003OLA1chr2

175087761

-PDE11Achr2

178592900

-
5CDS-intronENST00000284719ENST00000389683OLA1chr2

175087761

-PDE11Achr2

178592900

-
5CDS-intronENST00000284719ENST00000409504OLA1chr2

175087761

-PDE11Achr2

178592900

-
5CDS-intronENST00000284719ENST00000449286OLA1chr2

175087761

-PDE11Achr2

178592900

-
5CDS-intronENST00000284719ENST00000450799OLA1chr2

175087761

-PDE11Achr2

178592900

-
5CDS-intronENST00000409546ENST00000389683OLA1chr2

175087761

-PDE11Achr2

178592900

-
5CDS-intronENST00000409546ENST00000409504OLA1chr2

175087761

-PDE11Achr2

178592900

-
5CDS-intronENST00000409546ENST00000449286OLA1chr2

175087761

-PDE11Achr2

178592900

-
5CDS-intronENST00000409546ENST00000450799OLA1chr2

175087761

-PDE11Achr2

178592900

-
5CDS-intronENST00000428402ENST00000389683OLA1chr2

175087761

-PDE11Achr2

178592900

-
5CDS-intronENST00000428402ENST00000409504OLA1chr2

175087761

-PDE11Achr2

178592900

-
5CDS-intronENST00000428402ENST00000449286OLA1chr2

175087761

-PDE11Achr2

178592900

-
5CDS-intronENST00000428402ENST00000450799OLA1chr2

175087761

-PDE11Achr2

178592900

-
5UTR-3CDSENST00000344357ENST00000286063OLA1chr2

175087761

-PDE11Achr2

178592900

-
5UTR-3CDSENST00000344357ENST00000358450OLA1chr2

175087761

-PDE11Achr2

178592900

-
5UTR-5UTRENST00000344357ENST00000497003OLA1chr2

175087761

-PDE11Achr2

178592900

-
5UTR-intronENST00000344357ENST00000389683OLA1chr2

175087761

-PDE11Achr2

178592900

-
5UTR-intronENST00000344357ENST00000409504OLA1chr2

175087761

-PDE11Achr2

178592900

-
5UTR-intronENST00000344357ENST00000449286OLA1chr2

175087761

-PDE11Achr2

178592900

-
5UTR-intronENST00000344357ENST00000450799OLA1chr2

175087761

-PDE11Achr2

178592900

-
Frame-shiftENST00000409546ENST00000286063OLA1chr2

175087761

-PDE11Achr2

178592900

-
Frame-shiftENST00000409546ENST00000358450OLA1chr2

175087761

-PDE11Achr2

178592900

-
In-frameENST00000284719ENST00000286063OLA1chr2

175087761

-PDE11Achr2

178592900

-
In-frameENST00000284719ENST00000358450OLA1chr2

175087761

-PDE11Achr2

178592900

-
In-frameENST00000428402ENST00000286063OLA1chr2

175087761

-PDE11Achr2

178592900

-
In-frameENST00000428402ENST00000358450OLA1chr2

175087761

-PDE11Achr2

178592900

-
intron-3CDSENST00000392560ENST00000286063OLA1chr2

175087761

-PDE11Achr2

178592900

-
intron-3CDSENST00000392560ENST00000358450OLA1chr2

175087761

-PDE11Achr2

178592900

-
intron-5UTRENST00000392560ENST00000497003OLA1chr2

175087761

-PDE11Achr2

178592900

-
intron-intronENST00000392560ENST00000389683OLA1chr2

175087761

-PDE11Achr2

178592900

-
intron-intronENST00000392560ENST00000409504OLA1chr2

175087761

-PDE11Achr2

178592900

-
intron-intronENST00000392560ENST00000449286OLA1chr2

175087761

-PDE11Achr2

178592900

-
intron-intronENST00000392560ENST00000450799OLA1chr2

175087761

-PDE11Achr2

178592900

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000284719OLA1chr2175087761-ENST00000286063PDE11Achr2178592900-77896206351633332
ENST00000284719OLA1chr2175087761-ENST00000358450PDE11Achr2178592900-29726206351633332
ENST00000428402OLA1chr2175087761-ENST00000286063PDE11Achr2178592900-75663974121410332
ENST00000428402OLA1chr2175087761-ENST00000358450PDE11Achr2178592900-27493974121410332

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000284719ENST00000286063OLA1chr2175087761-PDE11Achr2178592900-0.0007511810.9992488
ENST00000284719ENST00000358450OLA1chr2175087761-PDE11Achr2178592900-0.0017429310.9982571
ENST00000428402ENST00000286063OLA1chr2175087761-PDE11Achr2178592900-0.0007672330.99923277
ENST00000428402ENST00000358450OLA1chr2175087761-PDE11Achr2178592900-0.0020073380.99799263

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Fusion Genomic Features for OLA1-PDE11A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for OLA1-PDE11A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:175087761/chr2:178592900)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOLA1chr2:175087761chr2:178592900ENST00000284719-41132_37124397.0Nucleotide bindingATP
HgeneOLA1chr2:175087761chr2:178592900ENST00000428402-4832_37124279.0Nucleotide bindingATP
TgenePDE11Achr2:175087761chr2:178592900ENST000003584501021402_558346684.0DomainNote=GAF 2
TgenePDE11Achr2:175087761chr2:178592900ENST000003584501021588_912346684.0DomainPDEase
TgenePDE11Achr2:175087761chr2:178592900ENST00000389683617217_370152490.0DomainNote=GAF 1
TgenePDE11Achr2:175087761chr2:178592900ENST00000389683617402_558152490.0DomainNote=GAF 2
TgenePDE11Achr2:175087761chr2:178592900ENST00000389683617588_912152490.0DomainPDEase
TgenePDE11Achr2:175087761chr2:178592900ENST00000409504820402_558238663.0DomainNote=GAF 2
TgenePDE11Achr2:175087761chr2:178592900ENST00000409504820588_912238663.0DomainPDEase
TgenePDE11Achr2:175087761chr2:178592900ENST00000449286819402_558238576.0DomainNote=GAF 2
TgenePDE11Achr2:175087761chr2:178592900ENST00000449286819588_912238576.0DomainPDEase

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOLA1chr2:175087761chr2:178592900ENST00000284719-41123_283124397.0DomainOBG-type G
HgeneOLA1chr2:175087761chr2:178592900ENST00000284719-411304_387124397.0DomainTGS
HgeneOLA1chr2:175087761chr2:178592900ENST00000344357-31023_2830239.0DomainOBG-type G
HgeneOLA1chr2:175087761chr2:178592900ENST00000344357-310304_3870239.0DomainTGS
HgeneOLA1chr2:175087761chr2:178592900ENST00000428402-4823_283124279.0DomainOBG-type G
HgeneOLA1chr2:175087761chr2:178592900ENST00000428402-48304_387124279.0DomainTGS
HgeneOLA1chr2:175087761chr2:178592900ENST00000284719-411267_274124397.0MotifNuclear export signal
HgeneOLA1chr2:175087761chr2:178592900ENST00000344357-310267_2740239.0MotifNuclear export signal
HgeneOLA1chr2:175087761chr2:178592900ENST00000428402-48267_274124279.0MotifNuclear export signal
HgeneOLA1chr2:175087761chr2:178592900ENST00000344357-31032_370239.0Nucleotide bindingATP
TgenePDE11Achr2:175087761chr2:178592900ENST00000286063920217_370596934.0DomainNote=GAF 1
TgenePDE11Achr2:175087761chr2:178592900ENST00000286063920402_558596934.0DomainNote=GAF 2
TgenePDE11Achr2:175087761chr2:178592900ENST00000286063920588_912596934.0DomainPDEase
TgenePDE11Achr2:175087761chr2:178592900ENST000003584501021217_370346684.0DomainNote=GAF 1
TgenePDE11Achr2:175087761chr2:178592900ENST00000409504820217_370238663.0DomainNote=GAF 1
TgenePDE11Achr2:175087761chr2:178592900ENST00000449286819217_370238576.0DomainNote=GAF 1


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Fusion Gene Sequence for OLA1-PDE11A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>61461_61461_1_OLA1-PDE11A_OLA1_chr2_175087761_ENST00000284719_PDE11A_chr2_178592900_ENST00000286063_length(transcript)=7789nt_BP=620nt
CCCCGGCCGGTTAGGCCAATGGGCGGGACGCGCGGGCAAGGCGGGGAGGGGCGGGGCCCATGGTCTGCGCGCAGGTGCCGCTCGGCGCCC
GGCCCGCCCGTTCCGCCGCTGTCGCCGCCGTCGTGCGTGCCGCTCGGCGGAGGGGACGGGCCTGCGTTCTCTCCTCCTTCCTCCCCGCCT
CCAGCTGCCGGCAGGACCTTTCTCTCGCTGCCGCTGGGACCCCGTGTCATCGCCCAGGCCGAGCACGATGCCCCCTAAAAAGGGAGGTGA
TGGAATTAAACCACCCCCAATCATTGGAAGATTTGGAACCTCACTGAAAATTGGTATTGTTGGATTGCCAAATGTTGGGAAATCTACTTT
CTTCAATGTGTTAACCAATAGTCAGGCTTCAGCAGAAAACTTCCCGTTCTGCACTATTGATCCTAATGAGAGCAGAGTACCTGTGCCAGA
TGAAAGGTTTGACTTTCTTTGTCAATACCACAAACCAGCAAGCAAAATTCCTGCCTTTCTAAATGTGGTGGATATTGCTGGCCTTGTGAA
AGGAGCTCACAATGGGCAGGGCCTGGGGAATGCTTTTTTATCTCATATTAGTGCCTGTGATGGCATCTTTCATCTAACACGCAGCCAACA
TCCCTCTGGTGTCAGAACTTGCCATCGATGACATTCATTTTGATGACTTTTCTCTCGACGTTGATGCCATGATCACAGCTGCTCTCCGGA
TGTTCATGGAGCTGGGGATGGTACAGAAATTTAAAATTGACTATGAGACACTGTGTAGGTGGCTTTTGACAGTGAGGAAAAACTATCGGA
TGGTTCTATACCACAACTGGAGACATGCCTTCAACGTGTGTCAGCTGATGTTCGCGATGTTAACCACTGCTGGGTTTCAAGACATTCTGA
CCGAGGTGGAAATTTTAGCGGTGATTGTGGGATGCCTGTGTCATGACCTCGACCACAGGGGAACCAACAATGCCTTCCAAGCTAAGAGTG
GCTCTGCCCTGGCCCAACTCTATGGAACCTCTGCTACCTTGGAGCATCACCATTTCAACCACGCCGTGATGATCCTTCAAAGTGAGGGTC
ACAATATCTTTGCTAACCTGTCCTCCAAGGAATATAGTGACCTTATGCAGCTTTTGAAGCAGTCAATATTGGCAACAGACCTCACGCTGT
ACTTTGAGAGGAGAACTGAATTCTTTGAACTTGTCAGTAAAGGAGAATACGATTGGAACATCAAAAACCATCGTGATATATTTCGATCAA
TGTTAATGACAGCCTGTGACCTTGGAGCCGTGACCAAACCGTGGGAGATCTCCAGACAGGTGGCAGAACTTGTAACCAGTGAGTTCTTCG
AACAAGGAGATCGGGAGAGATTAGAGCTCAAACTCACTCCTTCAGCAATTTTTGATCGGAACCGGAAGGATGAACTGCCTCGGTTGCAAC
TGGAGTGGATTGATAGCATCTGCATGCCTTTGTATCAGGCACTGGTGAAGGTCAACGTGAAACTGAAGCCGATGCTAGATTCAGTAGCTA
CAAACAGAAGTAAGTGGGAAGAGCTACACCAAAAACGACTGCTGGCCTCAACTGCCTCATCCTCCCCTGCCAGTGTTATGGTAGCCAAGG
AAGACAGGAACTAAACCTCCAGGTCAGCTGCAGCTGCAAAATGACTACAGCCTGAAGGGCCATTTTCAGTCCAGCAATGTCATCCTTTTG
TTCTTTTAGCTCAGAAAGACCTAACATCTCAAGGATGCACTGGGAAGCATGCCTGGGCTTTCACCTTGAAGCATGGTCAGCAGCAGAGAG
AGCAACGGGAAGGACAAAGAAAGAGGTGGGGCAGGGAGCACACCCCAGGACCCTCACTTTTCCCTAATGAACACGCATGGGCTGAAATGA
AGGCTCTGGGTAGGGGACTGTTTTGGATCCAAGGACCTGTGGACAGTCGGCCTACTTACTCTGAGCTGAGGGAACACTGAACAGTAAAAG
CGTCATTAGCGCTGCTTCGTTTTGTATAGGGCTTTTCTGTTTGTTACAAGCCAAACACTGCCTGTCTTTGCTTCCTGTCCCTGAATGCCT
TTTTGTGCCAGACTGTCCCAAGAATCCTAATTTGTATTCCATAGAGGTATTTTATTTTTAATCCTAGAGCTTCTTATTGATGGATCCTTT
AGAATTGCCTACCTAAAAGGTAAACTATACTATCCTTATAAATACTGATCAATCCCAGTTCTCCCCCTAAAAATGAATACATAGTAGGAC
TATAGCAAATGTGTTTGATGGGTAATTCTAGACTGGGACTATGGTACCCTTTTCCAGAGTTTTAAAATTCAACCTTCATTACAGACAAAG
TTTTCTCCCAGAAGGAATGGATTGATAGATTTTGATTAAAGTAAGGGTGGAAGGAAATCTGTAGCTGGATTTACCACAAGTGACATCTAG
AAACTATAGTTCACAGGACAGAGCAGAGCCATGGAGACTAAGCATTGACTACCTTGAGTTCTCCTAGTGAGGAGTTCTGGTATAAAATTT
AAGATTACTACCAGTAACCAACTTAAAGCAAACTATAGGGGTCCCTAATTTTGGATTTTTCCTTAAGTGTAAGAAACAATGCTTCAAATG
TTAAGAAATAACAGTCTGGGCAAAGAACGCATATTCTATAGGAAGCCAGGTTTACAATAGGTAAGAATAAACTGTATTAAGTAGATGTAA
TGACTAGAAAGCTGCTTTGCTCCCTATATTGAGAAATTGTGGACATGGTATGTGTTATCCAAAGAACATTGGGCTAGAAGATAGATTTCT
ATCCTTAGCTTTGGCATTATTGACTGGATTGACTTGAACAAGTCACTTAACTTCTACAAGCTTGTTTCCTTATTTGTCAAATTAGATTAC
ACTAGGAAACGATTCTCGAACATGTTTTAACCTTACAACTCTTTGTTCAAATAAATCTTTCAATGAATCCCCAACATATAAAACGTCAAA
AAGCTGAATTCCTATGTGAATTATAAGCAGGGTTTGGACATCCAGAGCACCTACAAACCTTCATCTCTTTGATTACGTACATGGGGGTCC
ACAGGGACTCTGAAGAGTTTGAAAATCCCTGGCCTAGATTAAACCTGAGAGCCATTCTAGCTCTTAAAAAAATCTGAAATTTACAAACCA
TTTTTCTTGTTATTGTTTTTGTTTCTTTGTTTGTTTGTTTTTTGAGACTGAGTTTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGT
GATCTCGGCTTACTGCAACCTCTGCTTCCTGGGTTCAAGCAATTCTCCAGCCTCAACCTCCTGAGAAGCTGGGATTACAGGTGCCTGCCA
CCACGCCTGGCTAATTTTTGTACTTTTAGTAGACACAGGGTTTCACCATGTTTGCCAGGCTGATCTCAAACTCCTGACCTCAGGTGAGCC
ACCCACCTCTGCCTCCGAAAGTGCTGGGATTACAGGCGTGAGCCACCGTACCCGGCCCTTGTTATTGTTATTAATCATTATCAATCATTA
ACTTTACAGATATTAAAGAAATAGGGGCCATGTTCTACATGCGACATTGTTTTCCTGGCACACAGTAGACAATTCAGGAAATGTCTGAAG
AAGGAATGGGTAAAATTAAGATACCAAAATGGAATTGAGGGGAGAGCAGGTAATTGTAGAGAAAAAGACTCTTTATGGCAAGAAACAAAG
TAAAAGAAATGTATAGACCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCAATTTGGAAGGCCGAGGCGGGCGGATCACGAGGTCAGGAG
ATCGAGACCGTCCTGGCTAACACGGTGAAACCCTGTCTCTACTAAAAAACACAAAACAAATTAGCCAGGCGCGGTGGCAGGCGTCTGTAG
TCCCAGCTACTGGGGAGGCTGAGGCAAGAGAATGGCGGGAACCCGCGAGGCGGAGCTTGCAGTGAGTCGAGATCACGTCACTGCCCTCCA
GCCTGGGCGACCAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGTATAAACCAGACTAAGAGGGGAATAA
AAGCAAGAAGAAAAAGAAACGTAAGAACACCAGTAAAGGAAAGACAGGGACCGAGACAGGTGGTTAAGGGAAATGAAAAAAAAAAAAAAA
AGGTGAAAGTCAATCCAAACAAAGAAAAATGGCACTTCCAACCAAAAAAAATGAAGGTGTAGAACCCTGTCATCAATTGCTCAGAAAAGA
GAGACACTTGAGCAGGGAGGGGTTTGAGAAAGGGGAGAAGGAAGGAGTGAGAGCCCTAAAAAATAATGTTCCTAGCTACCCTTTACAGCT
GTCTCTGCAGGGAAGACTGGAGAAAGTAGAGGGGGAAATGAATGCAGGAAGAAACTGCCTCTGCAGAGCAGGTAAGAGGAGGTTGTTCAG
ATTTATGGATTTTATTAAGCCAGTTTTCTGTATCACTCTGCTATAAAGGAAAATAGCTTCTGCAGGGCTGTCTCTCCTCCTTCAGGTGGG
GAACAAAGGGTGGGTGGAGTCAGGGACAGAGTCTGGTCTGCGAGATCGTGACGTGTCTGCAGCTCCGAAGCACTGCAGGTGTTTCTGGGT
AATGTGCCACATCATGTTTATATCACGAACGGGAATTGAAAATCAGTCTGTGTGAGGCAGAGATGAGCCCACATCTGTTATCCTCCCCAA
CAATAAATAAATAAATAGCCCAGACAAATGGATGCCAGTCCATCTACAGCAACATTTTAAAGCATGTGCTTTATGACAAAACTGGACCCA
GGGTCTGACAGAGACTGCAGGCTGCCGTGAGCACTGTAGCTATCCTGAACATTGATGCTACATATTGCTAAGGGGAACATAATTTATAGC
ATAAACCCTACAAGCTTCCACTAAGGTTGAGTTTTCCTCTCATTTTCTTGCCGTTTTATTGGCTTCACTGCATGGTTGCCAATAGCAACA
TCCACTGGTAGCAAGGGGAGTTCAACACCATTGCAATCTGCCATACAGTGGAGCCCTGACAATGTCAACCATCAATCTAGTAGCTGTTTG
TAATTGCCTCCATCTATTTCTCCTGTCTTGAGGTATCTTTCCTATTGTGGGTCAAGATTTAGAAACTGCTGACTAATGCCATGGGTCTGT
GTCTCCATGACTATGAAGCAGTGGACAGGAAGGTAGCAGCTTCCTGGTGCCAACAACCCCAGAGGTTAGAGGTTGAACTCTTGCGGGTTT
CAGGCGTTTTTAATCCCTTTTCTAAACAATTTATAATTTTGCAAGAATGTGAGGCATATGCAGTTATCCATATAATCTGCTTTTCCAAAA
AAGAGAAAGGAAGTTTCCCAGTCCTTATTATTAATGTTTATTTCCTATTGGAGAAAGACATTTGAAATATGAGCCTTCTTGTAAAAACTC
AAACTGACCAGATTATGTTTGCTTCCTCAGGTCTCTTGGCATTAATTGTTGAAATAACTTCATCCTACTTTTTCGATGAGATGTATTTTT
TTCAGACATATTTATTCTTACTAGTCACTATGTAGCTATTATGTGCACAATCTACAATGTAGTGGCAATCCTGGTGGGTAGGGACAGCTT
CACATACTGCAAAGGGTGCCATTCAGTGCATAGCAGACTGGAACTCCCTCCTAGCTTGGCCACCAGCTGAACCTGTAATCTTAGGACTCT
CCAAGTCTTAGAATCTCCATCTATTACATAAAAGCACTGACTTTTATTCAGTCCCCACACCAAAGGACCAAGACGTGTTTAGCTTTAAAG
AAATTTTCCAGATAATTTTCTTTTTTATTCTTCTCAAATAAAATAGCAACAAACCTAAAGCAGTCATCTTCTTAATAAAGACATAATAAA
ACTTACATATATGGGGTAGATGTAAGCACAATCATACTACAGATGTATCTTGAGCCTGTCTCTAATTATGATGAAAGATGTAGTCATCAA
TACAATTTAAAAAAAGATATGTCCTTTTTTTGAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGGGCAGTGGCACAATCACAGCCACTG
CAGCCTTGACCTCTCCAACTTAAGTGATCTTTCCTGCCTCAGCCTCATGAGTAGCTGGGACCACAGGTGTGCACCACCACACCCAGCTAA
ATTTTGTATTGTTTGTAAAGACGAGGCCTCACTATGCTGACCACACTGGTCTCGAACTCCTGGGCTCAAGCAATCCTCCTGCCTTGGCCT
CCCAAAGTGTTAGGGTTAGAGATATGAACCACCACACCCACCTTATATGTCCTTTTATTTCATAAAAAACAATTTTAGATTATCTGATAT
CACACATATCCCATAAATGGTAGTCATTAATTTAGAAGTGAATTTATAAAGTTAAGAGAAGTTAAAATTGCACATGCATTTTGTTTCTAA
AATCTGAGATGTCTATGCATTTCCAGGTATTGTATATTTGCAAATACATTGGGTTAGAAATCATCTTTAACATTTTGTGTTAGTGTAATA
ACAATATTATCTAATATTAATGCTGCCAGAATCCAGTTGCTTTTTCTGTGTATCAAAATTTATCATAACTTTTTCCACTTAACACTAGGT
AATTAAACAGAATCTGCCCAATTTATTCTGCAGTAAAATTATTTTAAAATCTATTTTTCCTGCTGACTCTTAGAAATTGCAGAAAGACAA
AAACCAGTTTCATCTCCAGTAATAGTGTGAAACAATTTCCTTCCAGTGGGACAGAAACCTAGACATACTAGGGAAAGATTTAAATATAAA
GAAAAATGCCTTGGCTGAAAAAAAAAAAAACCACCAAAACACAAAAAGGATTCATTAAAGCAACAGAACAAAACCTAATTTGGGACCCTA
AAAACTCTGGCAATGCCACTGTAATGAAGTTTCATTATCTGCTTCAGAGTAACAGTCTCTGAAATTGTTATTCTGCTACATGCTGTAAAG
AACTCCCAAAACTCAAATGTATCAGGAAATGTAAAGGTTAAGTCTGACTACAAGAAGGCCAAAATTGCACCAGCTTCCTAAGTGAAGAAT
AATAGAATAAAACATATAGAGGGCAGAAATAAAATGAGGTGTATCTGGAGAATTTCATGATGAGCATTTAGATTTAGCAATGCCCAATGT
CATGCTGACACTGTTTGTCATGACCTTGTCTTCAGCTAGTAATTTGGGGTTGTACTTTTTTAAATTTAATTTTGAATGTTCTTGCATGTT
TGGTACCTCTCTCCTCACTGCTAAAGATAAATTGTTTATCTGTATAACATAACTACACCAATGTCATTTTTGTATACGCTAGTACACAAA
TGTGTTTTTTTATTAAGTAATGAAGTATTTGCTGTGAAAAATGTATTATTTGTGCCACCGTTTATATCTGTGTTCATTTTCTGTGTGTAT
ATGCGTGTGTATTCGAATCTCAATTTTTCTTTTACTCTAGTTTAGATTAAGACATATTTAGATGAAATTTTAAAAATAACATTGGAAATA
GGAGGCTAAGTTTTGTTGAGTCTCATTCCCTTGGGGGGAAATTGCTTTTGCCATTTTATTTTCATGTACAATAACCTAAAAAGGATCTCC
TACTGACTTCCTTCCTAATTATTATTGTTTTACACGAAAGAAAGGAAATACGTTTTCAATTGAGTTGTTTGAAATCATTCACTTTGTGTA
GATTTCCCAGACTGATGTTTCATTGTAAGAATATTACATTATAGACAGGTTGGCCATTTCACAAGCAACTAATCCATAGTTTTGGAAGCC

>61461_61461_1_OLA1-PDE11A_OLA1_chr2_175087761_ENST00000284719_PDE11A_chr2_178592900_ENST00000286063_length(amino acids)=332AA_BP=
MVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTE
VEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYF
ERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLE

--------------------------------------------------------------
>61461_61461_2_OLA1-PDE11A_OLA1_chr2_175087761_ENST00000284719_PDE11A_chr2_178592900_ENST00000358450_length(transcript)=2972nt_BP=620nt
CCCCGGCCGGTTAGGCCAATGGGCGGGACGCGCGGGCAAGGCGGGGAGGGGCGGGGCCCATGGTCTGCGCGCAGGTGCCGCTCGGCGCCC
GGCCCGCCCGTTCCGCCGCTGTCGCCGCCGTCGTGCGTGCCGCTCGGCGGAGGGGACGGGCCTGCGTTCTCTCCTCCTTCCTCCCCGCCT
CCAGCTGCCGGCAGGACCTTTCTCTCGCTGCCGCTGGGACCCCGTGTCATCGCCCAGGCCGAGCACGATGCCCCCTAAAAAGGGAGGTGA
TGGAATTAAACCACCCCCAATCATTGGAAGATTTGGAACCTCACTGAAAATTGGTATTGTTGGATTGCCAAATGTTGGGAAATCTACTTT
CTTCAATGTGTTAACCAATAGTCAGGCTTCAGCAGAAAACTTCCCGTTCTGCACTATTGATCCTAATGAGAGCAGAGTACCTGTGCCAGA
TGAAAGGTTTGACTTTCTTTGTCAATACCACAAACCAGCAAGCAAAATTCCTGCCTTTCTAAATGTGGTGGATATTGCTGGCCTTGTGAA
AGGAGCTCACAATGGGCAGGGCCTGGGGAATGCTTTTTTATCTCATATTAGTGCCTGTGATGGCATCTTTCATCTAACACGCAGCCAACA
TCCCTCTGGTGTCAGAACTTGCCATCGATGACATTCATTTTGATGACTTTTCTCTCGACGTTGATGCCATGATCACAGCTGCTCTCCGGA
TGTTCATGGAGCTGGGGATGGTACAGAAATTTAAAATTGACTATGAGACACTGTGTAGGTGGCTTTTGACAGTGAGGAAAAACTATCGGA
TGGTTCTATACCACAACTGGAGACATGCCTTCAACGTGTGTCAGCTGATGTTCGCGATGTTAACCACTGCTGGGTTTCAAGACATTCTGA
CCGAGGTGGAAATTTTAGCGGTGATTGTGGGATGCCTGTGTCATGACCTCGACCACAGGGGAACCAACAATGCCTTCCAAGCTAAGAGTG
GCTCTGCCCTGGCCCAACTCTATGGAACCTCTGCTACCTTGGAGCATCACCATTTCAACCACGCCGTGATGATCCTTCAAAGTGAGGGTC
ACAATATCTTTGCTAACCTGTCCTCCAAGGAATATAGTGACCTTATGCAGCTTTTGAAGCAGTCAATATTGGCAACAGACCTCACGCTGT
ACTTTGAGAGGAGAACTGAATTCTTTGAACTTGTCAGTAAAGGAGAATACGATTGGAACATCAAAAACCATCGTGATATATTTCGATCAA
TGTTAATGACAGCCTGTGACCTTGGAGCCGTGACCAAACCGTGGGAGATCTCCAGACAGGTGGCAGAACTTGTAACCAGTGAGTTCTTCG
AACAAGGAGATCGGGAGAGATTAGAGCTCAAACTCACTCCTTCAGCAATTTTTGATCGGAACCGGAAGGATGAACTGCCTCGGTTGCAAC
TGGAGTGGATTGATAGCATCTGCATGCCTTTGTATCAGGCACTGGTGAAGGTCAACGTGAAACTGAAGCCGATGCTAGATTCAGTAGCTA
CAAACAGAAGTAAGTGGGAAGAGCTACACCAAAAACGACTGCTGGCCTCAACTGCCTCATCCTCCCCTGCCAGTGTTATGGTAGCCAAGG
AAGACAGGAACTAAACCTCCAGGTCAGCTGCAGCTGCAAAATGACTACAGCCTGAAGGGCCATTTTCAGTCCAGCAATGTCATCCTTTTG
TTCTTTTAGCTCAGAAAGACCTAACATCTCAAGGATGCACTGGGAAGCATGCCTGGGCTTTCACCTTGAAGCATGGTCAGCAGCAGAGAG
AGCAACGGGAAGGACAAAGAAAGAGGTGGGGCAGGGAGCACACCCCAGGACCCTCACTTTTCCCTAATGAACACGCATGGGCTGAAATGA
AGGCTCTGGGTAGGGGACTGTTTTGGATCCAAGGACCTGTGGACAGTCGGCCTACTTACTCTGAGCTGAGGGAACACTGAACAGTAAAAG
CGTCATTAGCGCTGCTTCGTTTTGTATAGGGCTTTTCTGTTTGTTACAAGCCAAACACTGCCTGTCTTTGCTTCCTGTCCCTGAATGCCT
TTTTGTGCCAGACTGTCCCAAGAATCCTAATTTGTATTCCATAGAGGTATTTTATTTTTAATCCTAGAGCTTCTTATTGATGGATCCTTT
AGAATTGCCTACCTAAAAGGTAAACTATACTATCCTTATAAATACTGATCAATCCCAGTTCTCCCCCTAAAAATGAATACATAGTAGGAC
TATAGCAAATGTGTTTGATGGGTAATTCTAGACTGGGACTATGGTACCCTTTTCCAGAGTTTTAAAATTCAACCTTCATTACAGACAAAG
TTTTCTCCCAGAAGGAATGGATTGATAGATTTTGATTAAAGTAAGGGTGGAAGGAAATCTGTAGCTGGATTTACCACAAGTGACATCTAG
AAACTATAGTTCACAGGACAGAGCAGAGCCATGGAGACTAAGCATTGACTACCTTGAGTTCTCCTAGTGAGGAGTTCTGGTATAAAATTT
AAGATTACTACCAGTAACCAACTTAAAGCAAACTATAGGGGTCCCTAATTTTGGATTTTTCCTTAAGTGTAAGAAACAATGCTTCAAATG
TTAAGAAATAACAGTCTGGGCAAAGAACGCATATTCTATAGGAAGCCAGGTTTACAATAGGTAAGAATAAACTGTATTAAGTAGATGTAA
TGACTAGAAAGCTGCTTTGCTCCCTATATTGAGAAATTGTGGACATGGTATGTGTTATCCAAAGAACATTGGGCTAGAAGATAGATTTCT
ATCCTTAGCTTTGGCATTATTGACTGGATTGACTTGAACAAGTCACTTAACTTCTACAAGCTTGTTTCCTTATTTGTCAAATTAGATTAC
ACTAGGAAACGATTCTCGAACATGTTTTAACCTTACAACTCTTTGTTCAAATAAATCTTTCAATGAATCCCCAACATATAAAACGTCAAA

>61461_61461_2_OLA1-PDE11A_OLA1_chr2_175087761_ENST00000284719_PDE11A_chr2_178592900_ENST00000358450_length(amino acids)=332AA_BP=
MVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTE
VEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYF
ERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLE

--------------------------------------------------------------
>61461_61461_3_OLA1-PDE11A_OLA1_chr2_175087761_ENST00000428402_PDE11A_chr2_178592900_ENST00000286063_length(transcript)=7566nt_BP=397nt
GTGTCATCGCCCAGGCCGAGCACGATGCCCCCTAAAAAGGGAGGTGATGGAATTAAACCACCCCCAATCATTGGAAGATTTGGAACCTCA
CTGAAAATTGGTATTGTTGGATTGCCAAATGTTGGGAAATCTACTTTCTTCAATGTGTTAACCAATAGTCAGGCTTCAGCAGAAAACTTC
CCGTTCTGCACTATTGATCCTAATGAGAGCAGAGTACCTGTGCCAGATGAAAGGTTTGACTTTCTTTGTCAATACCACAAACCAGCAAGC
AAAATTCCTGCCTTTCTAAATGTGGTGGATATTGCTGGCCTTGTGAAAGGAGCTCACAATGGGCAGGGCCTGGGGAATGCTTTTTTATCT
CATATTAGTGCCTGTGATGGCATCTTTCATCTAACACGCAGCCAACATCCCTCTGGTGTCAGAACTTGCCATCGATGACATTCATTTTGA
TGACTTTTCTCTCGACGTTGATGCCATGATCACAGCTGCTCTCCGGATGTTCATGGAGCTGGGGATGGTACAGAAATTTAAAATTGACTA
TGAGACACTGTGTAGGTGGCTTTTGACAGTGAGGAAAAACTATCGGATGGTTCTATACCACAACTGGAGACATGCCTTCAACGTGTGTCA
GCTGATGTTCGCGATGTTAACCACTGCTGGGTTTCAAGACATTCTGACCGAGGTGGAAATTTTAGCGGTGATTGTGGGATGCCTGTGTCA
TGACCTCGACCACAGGGGAACCAACAATGCCTTCCAAGCTAAGAGTGGCTCTGCCCTGGCCCAACTCTATGGAACCTCTGCTACCTTGGA
GCATCACCATTTCAACCACGCCGTGATGATCCTTCAAAGTGAGGGTCACAATATCTTTGCTAACCTGTCCTCCAAGGAATATAGTGACCT
TATGCAGCTTTTGAAGCAGTCAATATTGGCAACAGACCTCACGCTGTACTTTGAGAGGAGAACTGAATTCTTTGAACTTGTCAGTAAAGG
AGAATACGATTGGAACATCAAAAACCATCGTGATATATTTCGATCAATGTTAATGACAGCCTGTGACCTTGGAGCCGTGACCAAACCGTG
GGAGATCTCCAGACAGGTGGCAGAACTTGTAACCAGTGAGTTCTTCGAACAAGGAGATCGGGAGAGATTAGAGCTCAAACTCACTCCTTC
AGCAATTTTTGATCGGAACCGGAAGGATGAACTGCCTCGGTTGCAACTGGAGTGGATTGATAGCATCTGCATGCCTTTGTATCAGGCACT
GGTGAAGGTCAACGTGAAACTGAAGCCGATGCTAGATTCAGTAGCTACAAACAGAAGTAAGTGGGAAGAGCTACACCAAAAACGACTGCT
GGCCTCAACTGCCTCATCCTCCCCTGCCAGTGTTATGGTAGCCAAGGAAGACAGGAACTAAACCTCCAGGTCAGCTGCAGCTGCAAAATG
ACTACAGCCTGAAGGGCCATTTTCAGTCCAGCAATGTCATCCTTTTGTTCTTTTAGCTCAGAAAGACCTAACATCTCAAGGATGCACTGG
GAAGCATGCCTGGGCTTTCACCTTGAAGCATGGTCAGCAGCAGAGAGAGCAACGGGAAGGACAAAGAAAGAGGTGGGGCAGGGAGCACAC
CCCAGGACCCTCACTTTTCCCTAATGAACACGCATGGGCTGAAATGAAGGCTCTGGGTAGGGGACTGTTTTGGATCCAAGGACCTGTGGA
CAGTCGGCCTACTTACTCTGAGCTGAGGGAACACTGAACAGTAAAAGCGTCATTAGCGCTGCTTCGTTTTGTATAGGGCTTTTCTGTTTG
TTACAAGCCAAACACTGCCTGTCTTTGCTTCCTGTCCCTGAATGCCTTTTTGTGCCAGACTGTCCCAAGAATCCTAATTTGTATTCCATA
GAGGTATTTTATTTTTAATCCTAGAGCTTCTTATTGATGGATCCTTTAGAATTGCCTACCTAAAAGGTAAACTATACTATCCTTATAAAT
ACTGATCAATCCCAGTTCTCCCCCTAAAAATGAATACATAGTAGGACTATAGCAAATGTGTTTGATGGGTAATTCTAGACTGGGACTATG
GTACCCTTTTCCAGAGTTTTAAAATTCAACCTTCATTACAGACAAAGTTTTCTCCCAGAAGGAATGGATTGATAGATTTTGATTAAAGTA
AGGGTGGAAGGAAATCTGTAGCTGGATTTACCACAAGTGACATCTAGAAACTATAGTTCACAGGACAGAGCAGAGCCATGGAGACTAAGC
ATTGACTACCTTGAGTTCTCCTAGTGAGGAGTTCTGGTATAAAATTTAAGATTACTACCAGTAACCAACTTAAAGCAAACTATAGGGGTC
CCTAATTTTGGATTTTTCCTTAAGTGTAAGAAACAATGCTTCAAATGTTAAGAAATAACAGTCTGGGCAAAGAACGCATATTCTATAGGA
AGCCAGGTTTACAATAGGTAAGAATAAACTGTATTAAGTAGATGTAATGACTAGAAAGCTGCTTTGCTCCCTATATTGAGAAATTGTGGA
CATGGTATGTGTTATCCAAAGAACATTGGGCTAGAAGATAGATTTCTATCCTTAGCTTTGGCATTATTGACTGGATTGACTTGAACAAGT
CACTTAACTTCTACAAGCTTGTTTCCTTATTTGTCAAATTAGATTACACTAGGAAACGATTCTCGAACATGTTTTAACCTTACAACTCTT
TGTTCAAATAAATCTTTCAATGAATCCCCAACATATAAAACGTCAAAAAGCTGAATTCCTATGTGAATTATAAGCAGGGTTTGGACATCC
AGAGCACCTACAAACCTTCATCTCTTTGATTACGTACATGGGGGTCCACAGGGACTCTGAAGAGTTTGAAAATCCCTGGCCTAGATTAAA
CCTGAGAGCCATTCTAGCTCTTAAAAAAATCTGAAATTTACAAACCATTTTTCTTGTTATTGTTTTTGTTTCTTTGTTTGTTTGTTTTTT
GAGACTGAGTTTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGTGATCTCGGCTTACTGCAACCTCTGCTTCCTGGGTTCAAGCAAT
TCTCCAGCCTCAACCTCCTGAGAAGCTGGGATTACAGGTGCCTGCCACCACGCCTGGCTAATTTTTGTACTTTTAGTAGACACAGGGTTT
CACCATGTTTGCCAGGCTGATCTCAAACTCCTGACCTCAGGTGAGCCACCCACCTCTGCCTCCGAAAGTGCTGGGATTACAGGCGTGAGC
CACCGTACCCGGCCCTTGTTATTGTTATTAATCATTATCAATCATTAACTTTACAGATATTAAAGAAATAGGGGCCATGTTCTACATGCG
ACATTGTTTTCCTGGCACACAGTAGACAATTCAGGAAATGTCTGAAGAAGGAATGGGTAAAATTAAGATACCAAAATGGAATTGAGGGGA
GAGCAGGTAATTGTAGAGAAAAAGACTCTTTATGGCAAGAAACAAAGTAAAAGAAATGTATAGACCGGGCGCGGTGGCTCACGCCTGTAA
TCCCAGCAATTTGGAAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCGTCCTGGCTAACACGGTGAAACCCTGTCTCTACT
AAAAAACACAAAACAAATTAGCCAGGCGCGGTGGCAGGCGTCTGTAGTCCCAGCTACTGGGGAGGCTGAGGCAAGAGAATGGCGGGAACC
CGCGAGGCGGAGCTTGCAGTGAGTCGAGATCACGTCACTGCCCTCCAGCCTGGGCGACCAGCGAGACTCCGTCTCAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAGTATAAACCAGACTAAGAGGGGAATAAAAGCAAGAAGAAAAAGAAACGTAAGAACACCAGTAAAGGAAAG
ACAGGGACCGAGACAGGTGGTTAAGGGAAATGAAAAAAAAAAAAAAAAGGTGAAAGTCAATCCAAACAAAGAAAAATGGCACTTCCAACC
AAAAAAAATGAAGGTGTAGAACCCTGTCATCAATTGCTCAGAAAAGAGAGACACTTGAGCAGGGAGGGGTTTGAGAAAGGGGAGAAGGAA
GGAGTGAGAGCCCTAAAAAATAATGTTCCTAGCTACCCTTTACAGCTGTCTCTGCAGGGAAGACTGGAGAAAGTAGAGGGGGAAATGAAT
GCAGGAAGAAACTGCCTCTGCAGAGCAGGTAAGAGGAGGTTGTTCAGATTTATGGATTTTATTAAGCCAGTTTTCTGTATCACTCTGCTA
TAAAGGAAAATAGCTTCTGCAGGGCTGTCTCTCCTCCTTCAGGTGGGGAACAAAGGGTGGGTGGAGTCAGGGACAGAGTCTGGTCTGCGA
GATCGTGACGTGTCTGCAGCTCCGAAGCACTGCAGGTGTTTCTGGGTAATGTGCCACATCATGTTTATATCACGAACGGGAATTGAAAAT
CAGTCTGTGTGAGGCAGAGATGAGCCCACATCTGTTATCCTCCCCAACAATAAATAAATAAATAGCCCAGACAAATGGATGCCAGTCCAT
CTACAGCAACATTTTAAAGCATGTGCTTTATGACAAAACTGGACCCAGGGTCTGACAGAGACTGCAGGCTGCCGTGAGCACTGTAGCTAT
CCTGAACATTGATGCTACATATTGCTAAGGGGAACATAATTTATAGCATAAACCCTACAAGCTTCCACTAAGGTTGAGTTTTCCTCTCAT
TTTCTTGCCGTTTTATTGGCTTCACTGCATGGTTGCCAATAGCAACATCCACTGGTAGCAAGGGGAGTTCAACACCATTGCAATCTGCCA
TACAGTGGAGCCCTGACAATGTCAACCATCAATCTAGTAGCTGTTTGTAATTGCCTCCATCTATTTCTCCTGTCTTGAGGTATCTTTCCT
ATTGTGGGTCAAGATTTAGAAACTGCTGACTAATGCCATGGGTCTGTGTCTCCATGACTATGAAGCAGTGGACAGGAAGGTAGCAGCTTC
CTGGTGCCAACAACCCCAGAGGTTAGAGGTTGAACTCTTGCGGGTTTCAGGCGTTTTTAATCCCTTTTCTAAACAATTTATAATTTTGCA
AGAATGTGAGGCATATGCAGTTATCCATATAATCTGCTTTTCCAAAAAAGAGAAAGGAAGTTTCCCAGTCCTTATTATTAATGTTTATTT
CCTATTGGAGAAAGACATTTGAAATATGAGCCTTCTTGTAAAAACTCAAACTGACCAGATTATGTTTGCTTCCTCAGGTCTCTTGGCATT
AATTGTTGAAATAACTTCATCCTACTTTTTCGATGAGATGTATTTTTTTCAGACATATTTATTCTTACTAGTCACTATGTAGCTATTATG
TGCACAATCTACAATGTAGTGGCAATCCTGGTGGGTAGGGACAGCTTCACATACTGCAAAGGGTGCCATTCAGTGCATAGCAGACTGGAA
CTCCCTCCTAGCTTGGCCACCAGCTGAACCTGTAATCTTAGGACTCTCCAAGTCTTAGAATCTCCATCTATTACATAAAAGCACTGACTT
TTATTCAGTCCCCACACCAAAGGACCAAGACGTGTTTAGCTTTAAAGAAATTTTCCAGATAATTTTCTTTTTTATTCTTCTCAAATAAAA
TAGCAACAAACCTAAAGCAGTCATCTTCTTAATAAAGACATAATAAAACTTACATATATGGGGTAGATGTAAGCACAATCATACTACAGA
TGTATCTTGAGCCTGTCTCTAATTATGATGAAAGATGTAGTCATCAATACAATTTAAAAAAAGATATGTCCTTTTTTTGAGACAGGGTCT
TGCTCTGTCACCCAGGCTGGAGGGCAGTGGCACAATCACAGCCACTGCAGCCTTGACCTCTCCAACTTAAGTGATCTTTCCTGCCTCAGC
CTCATGAGTAGCTGGGACCACAGGTGTGCACCACCACACCCAGCTAAATTTTGTATTGTTTGTAAAGACGAGGCCTCACTATGCTGACCA
CACTGGTCTCGAACTCCTGGGCTCAAGCAATCCTCCTGCCTTGGCCTCCCAAAGTGTTAGGGTTAGAGATATGAACCACCACACCCACCT
TATATGTCCTTTTATTTCATAAAAAACAATTTTAGATTATCTGATATCACACATATCCCATAAATGGTAGTCATTAATTTAGAAGTGAAT
TTATAAAGTTAAGAGAAGTTAAAATTGCACATGCATTTTGTTTCTAAAATCTGAGATGTCTATGCATTTCCAGGTATTGTATATTTGCAA
ATACATTGGGTTAGAAATCATCTTTAACATTTTGTGTTAGTGTAATAACAATATTATCTAATATTAATGCTGCCAGAATCCAGTTGCTTT
TTCTGTGTATCAAAATTTATCATAACTTTTTCCACTTAACACTAGGTAATTAAACAGAATCTGCCCAATTTATTCTGCAGTAAAATTATT
TTAAAATCTATTTTTCCTGCTGACTCTTAGAAATTGCAGAAAGACAAAAACCAGTTTCATCTCCAGTAATAGTGTGAAACAATTTCCTTC
CAGTGGGACAGAAACCTAGACATACTAGGGAAAGATTTAAATATAAAGAAAAATGCCTTGGCTGAAAAAAAAAAAAACCACCAAAACACA
AAAAGGATTCATTAAAGCAACAGAACAAAACCTAATTTGGGACCCTAAAAACTCTGGCAATGCCACTGTAATGAAGTTTCATTATCTGCT
TCAGAGTAACAGTCTCTGAAATTGTTATTCTGCTACATGCTGTAAAGAACTCCCAAAACTCAAATGTATCAGGAAATGTAAAGGTTAAGT
CTGACTACAAGAAGGCCAAAATTGCACCAGCTTCCTAAGTGAAGAATAATAGAATAAAACATATAGAGGGCAGAAATAAAATGAGGTGTA
TCTGGAGAATTTCATGATGAGCATTTAGATTTAGCAATGCCCAATGTCATGCTGACACTGTTTGTCATGACCTTGTCTTCAGCTAGTAAT
TTGGGGTTGTACTTTTTTAAATTTAATTTTGAATGTTCTTGCATGTTTGGTACCTCTCTCCTCACTGCTAAAGATAAATTGTTTATCTGT
ATAACATAACTACACCAATGTCATTTTTGTATACGCTAGTACACAAATGTGTTTTTTTATTAAGTAATGAAGTATTTGCTGTGAAAAATG
TATTATTTGTGCCACCGTTTATATCTGTGTTCATTTTCTGTGTGTATATGCGTGTGTATTCGAATCTCAATTTTTCTTTTACTCTAGTTT
AGATTAAGACATATTTAGATGAAATTTTAAAAATAACATTGGAAATAGGAGGCTAAGTTTTGTTGAGTCTCATTCCCTTGGGGGGAAATT
GCTTTTGCCATTTTATTTTCATGTACAATAACCTAAAAAGGATCTCCTACTGACTTCCTTCCTAATTATTATTGTTTTACACGAAAGAAA
GGAAATACGTTTTCAATTGAGTTGTTTGAAATCATTCACTTTGTGTAGATTTCCCAGACTGATGTTTCATTGTAAGAATATTACATTATA
GACAGGTTGGCCATTTCACAAGCAACTAATCCATAGTTTTGGAAGCCCGCTTTAAGAGACCTGAATATCTTTGTTTTTAATAAAATACTT

>61461_61461_3_OLA1-PDE11A_OLA1_chr2_175087761_ENST00000428402_PDE11A_chr2_178592900_ENST00000286063_length(amino acids)=332AA_BP=
MVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTE
VEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYF
ERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLE

--------------------------------------------------------------
>61461_61461_4_OLA1-PDE11A_OLA1_chr2_175087761_ENST00000428402_PDE11A_chr2_178592900_ENST00000358450_length(transcript)=2749nt_BP=397nt
GTGTCATCGCCCAGGCCGAGCACGATGCCCCCTAAAAAGGGAGGTGATGGAATTAAACCACCCCCAATCATTGGAAGATTTGGAACCTCA
CTGAAAATTGGTATTGTTGGATTGCCAAATGTTGGGAAATCTACTTTCTTCAATGTGTTAACCAATAGTCAGGCTTCAGCAGAAAACTTC
CCGTTCTGCACTATTGATCCTAATGAGAGCAGAGTACCTGTGCCAGATGAAAGGTTTGACTTTCTTTGTCAATACCACAAACCAGCAAGC
AAAATTCCTGCCTTTCTAAATGTGGTGGATATTGCTGGCCTTGTGAAAGGAGCTCACAATGGGCAGGGCCTGGGGAATGCTTTTTTATCT
CATATTAGTGCCTGTGATGGCATCTTTCATCTAACACGCAGCCAACATCCCTCTGGTGTCAGAACTTGCCATCGATGACATTCATTTTGA
TGACTTTTCTCTCGACGTTGATGCCATGATCACAGCTGCTCTCCGGATGTTCATGGAGCTGGGGATGGTACAGAAATTTAAAATTGACTA
TGAGACACTGTGTAGGTGGCTTTTGACAGTGAGGAAAAACTATCGGATGGTTCTATACCACAACTGGAGACATGCCTTCAACGTGTGTCA
GCTGATGTTCGCGATGTTAACCACTGCTGGGTTTCAAGACATTCTGACCGAGGTGGAAATTTTAGCGGTGATTGTGGGATGCCTGTGTCA
TGACCTCGACCACAGGGGAACCAACAATGCCTTCCAAGCTAAGAGTGGCTCTGCCCTGGCCCAACTCTATGGAACCTCTGCTACCTTGGA
GCATCACCATTTCAACCACGCCGTGATGATCCTTCAAAGTGAGGGTCACAATATCTTTGCTAACCTGTCCTCCAAGGAATATAGTGACCT
TATGCAGCTTTTGAAGCAGTCAATATTGGCAACAGACCTCACGCTGTACTTTGAGAGGAGAACTGAATTCTTTGAACTTGTCAGTAAAGG
AGAATACGATTGGAACATCAAAAACCATCGTGATATATTTCGATCAATGTTAATGACAGCCTGTGACCTTGGAGCCGTGACCAAACCGTG
GGAGATCTCCAGACAGGTGGCAGAACTTGTAACCAGTGAGTTCTTCGAACAAGGAGATCGGGAGAGATTAGAGCTCAAACTCACTCCTTC
AGCAATTTTTGATCGGAACCGGAAGGATGAACTGCCTCGGTTGCAACTGGAGTGGATTGATAGCATCTGCATGCCTTTGTATCAGGCACT
GGTGAAGGTCAACGTGAAACTGAAGCCGATGCTAGATTCAGTAGCTACAAACAGAAGTAAGTGGGAAGAGCTACACCAAAAACGACTGCT
GGCCTCAACTGCCTCATCCTCCCCTGCCAGTGTTATGGTAGCCAAGGAAGACAGGAACTAAACCTCCAGGTCAGCTGCAGCTGCAAAATG
ACTACAGCCTGAAGGGCCATTTTCAGTCCAGCAATGTCATCCTTTTGTTCTTTTAGCTCAGAAAGACCTAACATCTCAAGGATGCACTGG
GAAGCATGCCTGGGCTTTCACCTTGAAGCATGGTCAGCAGCAGAGAGAGCAACGGGAAGGACAAAGAAAGAGGTGGGGCAGGGAGCACAC
CCCAGGACCCTCACTTTTCCCTAATGAACACGCATGGGCTGAAATGAAGGCTCTGGGTAGGGGACTGTTTTGGATCCAAGGACCTGTGGA
CAGTCGGCCTACTTACTCTGAGCTGAGGGAACACTGAACAGTAAAAGCGTCATTAGCGCTGCTTCGTTTTGTATAGGGCTTTTCTGTTTG
TTACAAGCCAAACACTGCCTGTCTTTGCTTCCTGTCCCTGAATGCCTTTTTGTGCCAGACTGTCCCAAGAATCCTAATTTGTATTCCATA
GAGGTATTTTATTTTTAATCCTAGAGCTTCTTATTGATGGATCCTTTAGAATTGCCTACCTAAAAGGTAAACTATACTATCCTTATAAAT
ACTGATCAATCCCAGTTCTCCCCCTAAAAATGAATACATAGTAGGACTATAGCAAATGTGTTTGATGGGTAATTCTAGACTGGGACTATG
GTACCCTTTTCCAGAGTTTTAAAATTCAACCTTCATTACAGACAAAGTTTTCTCCCAGAAGGAATGGATTGATAGATTTTGATTAAAGTA
AGGGTGGAAGGAAATCTGTAGCTGGATTTACCACAAGTGACATCTAGAAACTATAGTTCACAGGACAGAGCAGAGCCATGGAGACTAAGC
ATTGACTACCTTGAGTTCTCCTAGTGAGGAGTTCTGGTATAAAATTTAAGATTACTACCAGTAACCAACTTAAAGCAAACTATAGGGGTC
CCTAATTTTGGATTTTTCCTTAAGTGTAAGAAACAATGCTTCAAATGTTAAGAAATAACAGTCTGGGCAAAGAACGCATATTCTATAGGA
AGCCAGGTTTACAATAGGTAAGAATAAACTGTATTAAGTAGATGTAATGACTAGAAAGCTGCTTTGCTCCCTATATTGAGAAATTGTGGA
CATGGTATGTGTTATCCAAAGAACATTGGGCTAGAAGATAGATTTCTATCCTTAGCTTTGGCATTATTGACTGGATTGACTTGAACAAGT
CACTTAACTTCTACAAGCTTGTTTCCTTATTTGTCAAATTAGATTACACTAGGAAACGATTCTCGAACATGTTTTAACCTTACAACTCTT

>61461_61461_4_OLA1-PDE11A_OLA1_chr2_175087761_ENST00000428402_PDE11A_chr2_178592900_ENST00000358450_length(amino acids)=332AA_BP=
MVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTE
VEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYF
ERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLE

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Fusion Gene PPI Analysis for OLA1-PDE11A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for OLA1-PDE11A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for OLA1-PDE11A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource