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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:OLA1-SUN1 (FusionGDB2 ID:61465)

Fusion Gene Summary for OLA1-SUN1

check button Fusion gene summary
Fusion gene informationFusion gene name: OLA1-SUN1
Fusion gene ID: 61465
HgeneTgene
Gene symbol

OLA1

SUN1

Gene ID

29789

23353

Gene nameObg like ATPase 1Sad1 and UNC84 domain containing 1
SynonymsDOC45|GBP45|GTBP9|GTPBP9|PTD004UNC84A
Cytomap

2q31.1

7p22.3

Type of geneprotein-codingprotein-coding
Descriptionobg-like ATPase 1DNA damage-regulated overexpressed in cancer 45 proteinGTP-binding protein 9 (putative)GTP-binding protein PTD004homologous yeast-44.2 proteinSUN domain-containing protein 1Sad1 unc-84 domain protein 1protein unc-84 homolog Asad1/unc-84 protein-like 1unc-84 homolog A
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000284719, ENST00000409546, 
ENST00000428402, ENST00000344357, 
ENST00000392560, 		ENST00000389574, 
ENST00000401592, ENST00000403868, 
ENST00000405266, ENST00000413514, 
ENST00000425407, ENST00000452783, 
ENST00000457378, ENST00000469755, 
ENST00000456758, 
Fusion gene scores* DoF score10 X 5 X 8=40013 X 11 X 5=715
# samples 1216
** MAII scorelog2(12/400*10)=-1.73696559416621
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/715*10)=-2.15987133677839
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OLA1 [Title/Abstract] AND SUN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointOLA1(175087761)-SUN1(908986), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOLA1

GO:0046034

ATP metabolic process

17430889

TgeneSUN1

GO:0090286

cytoskeletal anchoring at nuclear membrane

18396275

TgeneSUN1

GO:0090292

nuclear matrix anchoring at nuclear membrane

18396275


check buttonFusion gene breakpoints across OLA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SUN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-IN-8462-11AOLA1chr2

175087761

-SUN1chr7

908986

+


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Fusion Gene ORF analysis for OLA1-SUN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000284719ENST00000389574OLA1chr2

175087761

-SUN1chr7

908986

+
5CDS-intronENST00000284719ENST00000401592OLA1chr2

175087761

-SUN1chr7

908986

+
5CDS-intronENST00000284719ENST00000403868OLA1chr2

175087761

-SUN1chr7

908986

+
5CDS-intronENST00000284719ENST00000405266OLA1chr2

175087761

-SUN1chr7

908986

+
5CDS-intronENST00000284719ENST00000413514OLA1chr2

175087761

-SUN1chr7

908986

+
5CDS-intronENST00000284719ENST00000425407OLA1chr2

175087761

-SUN1chr7

908986

+
5CDS-intronENST00000284719ENST00000452783OLA1chr2

175087761

-SUN1chr7

908986

+
5CDS-intronENST00000284719ENST00000457378OLA1chr2

175087761

-SUN1chr7

908986

+
5CDS-intronENST00000284719ENST00000469755OLA1chr2

175087761

-SUN1chr7

908986

+
5CDS-intronENST00000409546ENST00000389574OLA1chr2

175087761

-SUN1chr7

908986

+
5CDS-intronENST00000409546ENST00000401592OLA1chr2

175087761

-SUN1chr7

908986

+
5CDS-intronENST00000409546ENST00000403868OLA1chr2

175087761

-SUN1chr7

908986

+
5CDS-intronENST00000409546ENST00000405266OLA1chr2

175087761

-SUN1chr7

908986

+
5CDS-intronENST00000409546ENST00000413514OLA1chr2

175087761

-SUN1chr7

908986

+
5CDS-intronENST00000409546ENST00000425407OLA1chr2

175087761

-SUN1chr7

908986

+
5CDS-intronENST00000409546ENST00000452783OLA1chr2

175087761

-SUN1chr7

908986

+
5CDS-intronENST00000409546ENST00000457378OLA1chr2

175087761

-SUN1chr7

908986

+
5CDS-intronENST00000409546ENST00000469755OLA1chr2

175087761

-SUN1chr7

908986

+
5CDS-intronENST00000428402ENST00000389574OLA1chr2

175087761

-SUN1chr7

908986

+
5CDS-intronENST00000428402ENST00000401592OLA1chr2

175087761

-SUN1chr7

908986

+
5CDS-intronENST00000428402ENST00000403868OLA1chr2

175087761

-SUN1chr7

908986

+
5CDS-intronENST00000428402ENST00000405266OLA1chr2

175087761

-SUN1chr7

908986

+
5CDS-intronENST00000428402ENST00000413514OLA1chr2

175087761

-SUN1chr7

908986

+
5CDS-intronENST00000428402ENST00000425407OLA1chr2

175087761

-SUN1chr7

908986

+
5CDS-intronENST00000428402ENST00000452783OLA1chr2

175087761

-SUN1chr7

908986

+
5CDS-intronENST00000428402ENST00000457378OLA1chr2

175087761

-SUN1chr7

908986

+
5CDS-intronENST00000428402ENST00000469755OLA1chr2

175087761

-SUN1chr7

908986

+
5UTR-3CDSENST00000344357ENST00000456758OLA1chr2

175087761

-SUN1chr7

908986

+
5UTR-intronENST00000344357ENST00000389574OLA1chr2

175087761

-SUN1chr7

908986

+
5UTR-intronENST00000344357ENST00000401592OLA1chr2

175087761

-SUN1chr7

908986

+
5UTR-intronENST00000344357ENST00000403868OLA1chr2

175087761

-SUN1chr7

908986

+
5UTR-intronENST00000344357ENST00000405266OLA1chr2

175087761

-SUN1chr7

908986

+
5UTR-intronENST00000344357ENST00000413514OLA1chr2

175087761

-SUN1chr7

908986

+
5UTR-intronENST00000344357ENST00000425407OLA1chr2

175087761

-SUN1chr7

908986

+
5UTR-intronENST00000344357ENST00000452783OLA1chr2

175087761

-SUN1chr7

908986

+
5UTR-intronENST00000344357ENST00000457378OLA1chr2

175087761

-SUN1chr7

908986

+
5UTR-intronENST00000344357ENST00000469755OLA1chr2

175087761

-SUN1chr7

908986

+
Frame-shiftENST00000409546ENST00000456758OLA1chr2

175087761

-SUN1chr7

908986

+
In-frameENST00000284719ENST00000456758OLA1chr2

175087761

-SUN1chr7

908986

+
In-frameENST00000428402ENST00000456758OLA1chr2

175087761

-SUN1chr7

908986

+
intron-3CDSENST00000392560ENST00000456758OLA1chr2

175087761

-SUN1chr7

908986

+
intron-intronENST00000392560ENST00000389574OLA1chr2

175087761

-SUN1chr7

908986

+
intron-intronENST00000392560ENST00000401592OLA1chr2

175087761

-SUN1chr7

908986

+
intron-intronENST00000392560ENST00000403868OLA1chr2

175087761

-SUN1chr7

908986

+
intron-intronENST00000392560ENST00000405266OLA1chr2

175087761

-SUN1chr7

908986

+
intron-intronENST00000392560ENST00000413514OLA1chr2

175087761

-SUN1chr7

908986

+
intron-intronENST00000392560ENST00000425407OLA1chr2

175087761

-SUN1chr7

908986

+
intron-intronENST00000392560ENST00000452783OLA1chr2

175087761

-SUN1chr7

908986

+
intron-intronENST00000392560ENST00000457378OLA1chr2

175087761

-SUN1chr7

908986

+
intron-intronENST00000392560ENST00000469755OLA1chr2

175087761

-SUN1chr7

908986

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000284719OLA1chr2175087761-ENST00000456758SUN1chr7908986+258762064624186
ENST00000428402OLA1chr2175087761-ENST00000456758SUN1chr7908986+236439724401125

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000284719ENST00000456758OLA1chr2175087761-SUN1chr7908986+0.0421285070.95787156
ENST00000428402ENST00000456758OLA1chr2175087761-SUN1chr7908986+0.105570560.89442945

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Fusion Genomic Features for OLA1-SUN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
OLA1chr2175087760-SUN1chr7908985+8.37E-101
OLA1chr2175087760-SUN1chr7908985+8.37E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for OLA1-SUN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:175087761/chr7:908986)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOLA1chr2:175087761chr7:908986ENST00000284719-41132_37124397.0Nucleotide bindingATP
HgeneOLA1chr2:175087761chr7:908986ENST00000428402-4832_37124279.0Nucleotide bindingATP
TgeneSUN1chr2:175087761chr7:908986ENST0000040386805393_4300258.0Coiled coilOntology_term=ECO:0000255
TgeneSUN1chr2:175087761chr7:908986ENST0000040386805455_4930258.0Coiled coilOntology_term=ECO:0000255
TgeneSUN1chr2:175087761chr7:908986ENST0000040386805501_5230258.0Coiled coilOntology_term=ECO:0000255
TgeneSUN1chr2:175087761chr7:908986ENST0000045737807393_4300279.0Coiled coilOntology_term=ECO:0000255
TgeneSUN1chr2:175087761chr7:908986ENST0000045737807455_4930279.0Coiled coilOntology_term=ECO:0000255
TgeneSUN1chr2:175087761chr7:908986ENST0000045737807501_5230279.0Coiled coilOntology_term=ECO:0000255
TgeneSUN1chr2:175087761chr7:908986ENST000003895741418649_811577703.0DomainSUN
TgeneSUN1chr2:175087761chr7:908986ENST0000040386805649_8110258.0DomainSUN
TgeneSUN1chr2:175087761chr7:908986ENST000004254071418649_811577703.0DomainSUN
TgeneSUN1chr2:175087761chr7:908986ENST000004527831317649_811557683.0DomainSUN
TgeneSUN1chr2:175087761chr7:908986ENST0000045737807649_8110279.0DomainSUN
TgeneSUN1chr2:175087761chr7:908986ENST00000403868051_1380258.0RegionNote=LMNA-binding
TgeneSUN1chr2:175087761chr7:908986ENST0000040386805209_3020258.0RegionNote=SYNE2-binding
TgeneSUN1chr2:175087761chr7:908986ENST0000040386805223_3020258.0RegionNote=EMD-binding
TgeneSUN1chr2:175087761chr7:908986ENST00000457378071_1380279.0RegionNote=LMNA-binding
TgeneSUN1chr2:175087761chr7:908986ENST0000045737807209_3020279.0RegionNote=SYNE2-binding
TgeneSUN1chr2:175087761chr7:908986ENST0000045737807223_3020279.0RegionNote=EMD-binding
TgeneSUN1chr2:175087761chr7:908986ENST00000403868051_3150258.0Topological domainNuclear
TgeneSUN1chr2:175087761chr7:908986ENST0000040386805336_8120258.0Topological domainPerinuclear space
TgeneSUN1chr2:175087761chr7:908986ENST00000457378071_3150279.0Topological domainNuclear
TgeneSUN1chr2:175087761chr7:908986ENST0000045737807336_8120279.0Topological domainPerinuclear space
TgeneSUN1chr2:175087761chr7:908986ENST0000040386805316_3350258.0TransmembraneNote=Helical
TgeneSUN1chr2:175087761chr7:908986ENST0000045737807316_3350279.0TransmembraneNote=Helical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOLA1chr2:175087761chr7:908986ENST00000284719-41123_283124397.0DomainOBG-type G
HgeneOLA1chr2:175087761chr7:908986ENST00000284719-411304_387124397.0DomainTGS
HgeneOLA1chr2:175087761chr7:908986ENST00000344357-31023_2830239.0DomainOBG-type G
HgeneOLA1chr2:175087761chr7:908986ENST00000344357-310304_3870239.0DomainTGS
HgeneOLA1chr2:175087761chr7:908986ENST00000428402-4823_283124279.0DomainOBG-type G
HgeneOLA1chr2:175087761chr7:908986ENST00000428402-48304_387124279.0DomainTGS
HgeneOLA1chr2:175087761chr7:908986ENST00000284719-411267_274124397.0MotifNuclear export signal
HgeneOLA1chr2:175087761chr7:908986ENST00000344357-310267_2740239.0MotifNuclear export signal
HgeneOLA1chr2:175087761chr7:908986ENST00000428402-48267_274124279.0MotifNuclear export signal
HgeneOLA1chr2:175087761chr7:908986ENST00000344357-31032_370239.0Nucleotide bindingATP
TgeneSUN1chr2:175087761chr7:908986ENST000003895741418393_430577703.0Coiled coilOntology_term=ECO:0000255
TgeneSUN1chr2:175087761chr7:908986ENST000003895741418455_493577703.0Coiled coilOntology_term=ECO:0000255
TgeneSUN1chr2:175087761chr7:908986ENST000003895741418501_523577703.0Coiled coilOntology_term=ECO:0000255
TgeneSUN1chr2:175087761chr7:908986ENST000004015921519393_430660786.0Coiled coilOntology_term=ECO:0000255
TgeneSUN1chr2:175087761chr7:908986ENST000004015921519455_493660786.0Coiled coilOntology_term=ECO:0000255
TgeneSUN1chr2:175087761chr7:908986ENST000004015921519501_523660786.0Coiled coilOntology_term=ECO:0000255
TgeneSUN1chr2:175087761chr7:908986ENST000004254071418393_430577703.0Coiled coilOntology_term=ECO:0000255
TgeneSUN1chr2:175087761chr7:908986ENST000004254071418455_493577703.0Coiled coilOntology_term=ECO:0000255
TgeneSUN1chr2:175087761chr7:908986ENST000004254071418501_523577703.0Coiled coilOntology_term=ECO:0000255
TgeneSUN1chr2:175087761chr7:908986ENST000004527831317393_430557683.0Coiled coilOntology_term=ECO:0000255
TgeneSUN1chr2:175087761chr7:908986ENST000004527831317455_493557683.0Coiled coilOntology_term=ECO:0000255
TgeneSUN1chr2:175087761chr7:908986ENST000004527831317501_523557683.0Coiled coilOntology_term=ECO:0000255
TgeneSUN1chr2:175087761chr7:908986ENST000004015921519649_811660786.0DomainSUN
TgeneSUN1chr2:175087761chr7:908986ENST0000038957414181_138577703.0RegionNote=LMNA-binding
TgeneSUN1chr2:175087761chr7:908986ENST000003895741418209_302577703.0RegionNote=SYNE2-binding
TgeneSUN1chr2:175087761chr7:908986ENST000003895741418223_302577703.0RegionNote=EMD-binding
TgeneSUN1chr2:175087761chr7:908986ENST0000040159215191_138660786.0RegionNote=LMNA-binding
TgeneSUN1chr2:175087761chr7:908986ENST000004015921519209_302660786.0RegionNote=SYNE2-binding
TgeneSUN1chr2:175087761chr7:908986ENST000004015921519223_302660786.0RegionNote=EMD-binding
TgeneSUN1chr2:175087761chr7:908986ENST0000042540714181_138577703.0RegionNote=LMNA-binding
TgeneSUN1chr2:175087761chr7:908986ENST000004254071418209_302577703.0RegionNote=SYNE2-binding
TgeneSUN1chr2:175087761chr7:908986ENST000004254071418223_302577703.0RegionNote=EMD-binding
TgeneSUN1chr2:175087761chr7:908986ENST0000045278313171_138557683.0RegionNote=LMNA-binding
TgeneSUN1chr2:175087761chr7:908986ENST000004527831317209_302557683.0RegionNote=SYNE2-binding
TgeneSUN1chr2:175087761chr7:908986ENST000004527831317223_302557683.0RegionNote=EMD-binding
TgeneSUN1chr2:175087761chr7:908986ENST0000038957414181_315577703.0Topological domainNuclear
TgeneSUN1chr2:175087761chr7:908986ENST000003895741418336_812577703.0Topological domainPerinuclear space
TgeneSUN1chr2:175087761chr7:908986ENST0000040159215191_315660786.0Topological domainNuclear
TgeneSUN1chr2:175087761chr7:908986ENST000004015921519336_812660786.0Topological domainPerinuclear space
TgeneSUN1chr2:175087761chr7:908986ENST0000042540714181_315577703.0Topological domainNuclear
TgeneSUN1chr2:175087761chr7:908986ENST000004254071418336_812577703.0Topological domainPerinuclear space
TgeneSUN1chr2:175087761chr7:908986ENST0000045278313171_315557683.0Topological domainNuclear
TgeneSUN1chr2:175087761chr7:908986ENST000004527831317336_812557683.0Topological domainPerinuclear space
TgeneSUN1chr2:175087761chr7:908986ENST000003895741418316_335577703.0TransmembraneNote=Helical
TgeneSUN1chr2:175087761chr7:908986ENST000004015921519316_335660786.0TransmembraneNote=Helical
TgeneSUN1chr2:175087761chr7:908986ENST000004254071418316_335577703.0TransmembraneNote=Helical
TgeneSUN1chr2:175087761chr7:908986ENST000004527831317316_335557683.0TransmembraneNote=Helical


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Fusion Gene Sequence for OLA1-SUN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>61465_61465_1_OLA1-SUN1_OLA1_chr2_175087761_ENST00000284719_SUN1_chr7_908986_ENST00000456758_length(transcript)=2587nt_BP=620nt
CCCCGGCCGGTTAGGCCAATGGGCGGGACGCGCGGGCAAGGCGGGGAGGGGCGGGGCCCATGGTCTGCGCGCAGGTGCCGCTCGGCGCCC
GGCCCGCCCGTTCCGCCGCTGTCGCCGCCGTCGTGCGTGCCGCTCGGCGGAGGGGACGGGCCTGCGTTCTCTCCTCCTTCCTCCCCGCCT
CCAGCTGCCGGCAGGACCTTTCTCTCGCTGCCGCTGGGACCCCGTGTCATCGCCCAGGCCGAGCACGATGCCCCCTAAAAAGGGAGGTGA
TGGAATTAAACCACCCCCAATCATTGGAAGATTTGGAACCTCACTGAAAATTGGTATTGTTGGATTGCCAAATGTTGGGAAATCTACTTT
CTTCAATGTGTTAACCAATAGTCAGGCTTCAGCAGAAAACTTCCCGTTCTGCACTATTGATCCTAATGAGAGCAGAGTACCTGTGCCAGA
TGAAAGGTTTGACTTTCTTTGTCAATACCACAAACCAGCAAGCAAAATTCCTGCCTTTCTAAATGTGGTGGATATTGCTGGCCTTGTGAA
AGGAGCTCACAATGGGCAGGGCCTGGGGAATGCTTTTTTATCTCATATTAGTGCCTGTGATGGCATCTTTCATCTAACACCCTGACATTT
ACCCCGGTAACTGCTGGGCATTTAAAGGCTCCCAGGGGTACCTGGTGGTGAGGCTCTCCATGATGATCCACCCAGCCGCCTTCACTCTGG
AGCACATCCCTAAGACGCTGTCGCCAACAGGCAACATCAGCAGCGCCCCCAAGGACTTCGCCGTCTATGGATTAGAAAATGAGTATCAGG
AAGAAGGGCAGCTTCTGGGACAGTTCACGTATGATCAGGATGGGGAGTCGCTCCAGATGTTCCAGGCCCTGAAAAGACCCGACGACACAG
CTTTCCAAATAGTGGAACTTCGGATTTTTTCTAACTGGGGCCATCCTGAGTATACCTGTCTGTATCGGTTCAGAGTTCATGGCGAACCTG
TCAAGTGAAGACACTACTCATTATTTTTGTACATTTTTGTATATACTGGGACAGCGTGAAACACTGGAATCCTTCATGGACGAGGGCATA
TACAATGATGGGACAGTGCCACACTCCTTCAATAAACGTGGCTGCTGGCCAGAGGACGTGAGCGTGTGACGGGCGCCTTGGCGCCACCTG
TTGGGTGCTCACTGCCTCTGCAGGTGCAGAGGGGTCAGCAGCAGGAGAAGCGTGTTGAACACGTGGCTCTCAGACACTCCTTGTTTTTAA
CGGGAAGCTCTTTGCATTTGCATTTCCTCAACAAAGGAGCAAAGCAGAGGAAGCTGAGAGTCTGGCGTGTTCTTGACGCTTTGGTCTTCA
GCCTTGCACTGGCTCTTCTAAAGGACTTTTGGAGGGCAGATAATTTCATCTGTTAAATCCAACACACATTTCTTTCAGGGAAAAACAATG
TCACCAAATTTTCAGAGTTCTAAACTCCTTTCCTTCAAGCCGGAATTTTCCTTTTTTCAGCACCAGTAGGTACTAAGTCTCCAGATGGGG
AAATAACTAAAATGTGTTTTTCTGCTTTGTTCGCTCTTACTTCTGAGGAAGGTTTCCAGTCAGGACTCGCTGTACCAATATCCATGGAGG
AATATGGGAGCGTTTCGCTCTCCTTGTAGGCTGAAGTCAGTCTGACTTGAAGGGGCCTGGTTTGGATCTAAGCAAACACCCAGATGGGGT
TCTCTGGTCTCAGCAAGGCTTTTCCTGTTGGGAGTCACAGTAAACAGAAACCCAAAAATCTCATCTTGGGTGTTTTCAGGGCTTGTTTTG
AGTTTTGCTGAATAGGGAGCGCAAGACGCCCTGAGCCTCCCTCTCACTGGTGGTGATAAGAGGAGCCGTCTGGTGTGTCAGGGTCACGAA
CCCGTTACATTTCAGGACGATCCTTTTTCCTTCAGCAGCATTTCTTACTGGCTGTGGCTGGAATCTGCCTTTTATCACAGCTGTCACCAT
TCTCACGTGATTCTTGTGAGACTCTTTTTGGTTATAATTACTATTTAATATTTAGACTATTTTACTGAGCAGACTTTATAAATGAGATAT
CTACAAGGCACTTAAAGTGTTACAGATGTTTTACCTTAAGAATTATTTAAGTTGTGTTGGGTTAAGACAGTTTTCAGTGTACCGTAAATG
TTGTGTTTTCAGAAAAAGACAAAACGATGGTGCTGACTGGTTTTCTGTATATTGCACAACAGTCCTCAAATACACTGATGTATGAAACTA
TTCATACATCAAGCAGCATTTTTTTCACTCTCCTTAGAATTGGAACTATGCAGTTAAGGCAGATAAAATGTACAGATGTTTCATATATTA
CAGGTTACATATATAAATCAAAATTTCCTATATAAAACTGATTTGGGATTTGGGGTGGAAATATTTTGAATATTAATTTATTTTTAAAGA
TGCAAGATAGGACTTTGTGCAATGTATTTTTGTAAATGCTTTTCAAAATATCTGTCTTTGGTAGTGCTTCTGCTGCTGCCACCAAATTGA

>61465_61465_1_OLA1-SUN1_OLA1_chr2_175087761_ENST00000284719_SUN1_chr7_908986_ENST00000456758_length(amino acids)=186AA_BP=
MRAGAARRPARPFRRCRRRRACRSAEGTGLRSLLLPPRLQLPAGPFSRCRWDPVSSPRPSTMPPKKGGDGIKPPPIIGRFGTSLKIGIVG
LPNVGKSTFFNVLTNSQASAENFPFCTIDPNESRVPVPDERFDFLCQYHKPASKIPAFLNVVDIAGLVKGAHNGQGLGNAFLSHISACDG

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>61465_61465_2_OLA1-SUN1_OLA1_chr2_175087761_ENST00000428402_SUN1_chr7_908986_ENST00000456758_length(transcript)=2364nt_BP=397nt
GTGTCATCGCCCAGGCCGAGCACGATGCCCCCTAAAAAGGGAGGTGATGGAATTAAACCACCCCCAATCATTGGAAGATTTGGAACCTCA
CTGAAAATTGGTATTGTTGGATTGCCAAATGTTGGGAAATCTACTTTCTTCAATGTGTTAACCAATAGTCAGGCTTCAGCAGAAAACTTC
CCGTTCTGCACTATTGATCCTAATGAGAGCAGAGTACCTGTGCCAGATGAAAGGTTTGACTTTCTTTGTCAATACCACAAACCAGCAAGC
AAAATTCCTGCCTTTCTAAATGTGGTGGATATTGCTGGCCTTGTGAAAGGAGCTCACAATGGGCAGGGCCTGGGGAATGCTTTTTTATCT
CATATTAGTGCCTGTGATGGCATCTTTCATCTAACACCCTGACATTTACCCCGGTAACTGCTGGGCATTTAAAGGCTCCCAGGGGTACCT
GGTGGTGAGGCTCTCCATGATGATCCACCCAGCCGCCTTCACTCTGGAGCACATCCCTAAGACGCTGTCGCCAACAGGCAACATCAGCAG
CGCCCCCAAGGACTTCGCCGTCTATGGATTAGAAAATGAGTATCAGGAAGAAGGGCAGCTTCTGGGACAGTTCACGTATGATCAGGATGG
GGAGTCGCTCCAGATGTTCCAGGCCCTGAAAAGACCCGACGACACAGCTTTCCAAATAGTGGAACTTCGGATTTTTTCTAACTGGGGCCA
TCCTGAGTATACCTGTCTGTATCGGTTCAGAGTTCATGGCGAACCTGTCAAGTGAAGACACTACTCATTATTTTTGTACATTTTTGTATA
TACTGGGACAGCGTGAAACACTGGAATCCTTCATGGACGAGGGCATATACAATGATGGGACAGTGCCACACTCCTTCAATAAACGTGGCT
GCTGGCCAGAGGACGTGAGCGTGTGACGGGCGCCTTGGCGCCACCTGTTGGGTGCTCACTGCCTCTGCAGGTGCAGAGGGGTCAGCAGCA
GGAGAAGCGTGTTGAACACGTGGCTCTCAGACACTCCTTGTTTTTAACGGGAAGCTCTTTGCATTTGCATTTCCTCAACAAAGGAGCAAA
GCAGAGGAAGCTGAGAGTCTGGCGTGTTCTTGACGCTTTGGTCTTCAGCCTTGCACTGGCTCTTCTAAAGGACTTTTGGAGGGCAGATAA
TTTCATCTGTTAAATCCAACACACATTTCTTTCAGGGAAAAACAATGTCACCAAATTTTCAGAGTTCTAAACTCCTTTCCTTCAAGCCGG
AATTTTCCTTTTTTCAGCACCAGTAGGTACTAAGTCTCCAGATGGGGAAATAACTAAAATGTGTTTTTCTGCTTTGTTCGCTCTTACTTC
TGAGGAAGGTTTCCAGTCAGGACTCGCTGTACCAATATCCATGGAGGAATATGGGAGCGTTTCGCTCTCCTTGTAGGCTGAAGTCAGTCT
GACTTGAAGGGGCCTGGTTTGGATCTAAGCAAACACCCAGATGGGGTTCTCTGGTCTCAGCAAGGCTTTTCCTGTTGGGAGTCACAGTAA
ACAGAAACCCAAAAATCTCATCTTGGGTGTTTTCAGGGCTTGTTTTGAGTTTTGCTGAATAGGGAGCGCAAGACGCCCTGAGCCTCCCTC
TCACTGGTGGTGATAAGAGGAGCCGTCTGGTGTGTCAGGGTCACGAACCCGTTACATTTCAGGACGATCCTTTTTCCTTCAGCAGCATTT
CTTACTGGCTGTGGCTGGAATCTGCCTTTTATCACAGCTGTCACCATTCTCACGTGATTCTTGTGAGACTCTTTTTGGTTATAATTACTA
TTTAATATTTAGACTATTTTACTGAGCAGACTTTATAAATGAGATATCTACAAGGCACTTAAAGTGTTACAGATGTTTTACCTTAAGAAT
TATTTAAGTTGTGTTGGGTTAAGACAGTTTTCAGTGTACCGTAAATGTTGTGTTTTCAGAAAAAGACAAAACGATGGTGCTGACTGGTTT
TCTGTATATTGCACAACAGTCCTCAAATACACTGATGTATGAAACTATTCATACATCAAGCAGCATTTTTTTCACTCTCCTTAGAATTGG
AACTATGCAGTTAAGGCAGATAAAATGTACAGATGTTTCATATATTACAGGTTACATATATAAATCAAAATTTCCTATATAAAACTGATT
TGGGATTTGGGGTGGAAATATTTTGAATATTAATTTATTTTTAAAGATGCAAGATAGGACTTTGTGCAATGTATTTTTGTAAATGCTTTT
CAAAATATCTGTCTTTGGTAGTGCTTCTGCTGCTGCCACCAAATTGATAAGATGCTATTAAGAGGTTTAAATAAAGAGTTTTAATTTTTA

>61465_61465_2_OLA1-SUN1_OLA1_chr2_175087761_ENST00000428402_SUN1_chr7_908986_ENST00000456758_length(amino acids)=125AA_BP=
MPPKKGGDGIKPPPIIGRFGTSLKIGIVGLPNVGKSTFFNVLTNSQASAENFPFCTIDPNESRVPVPDERFDFLCQYHKPASKIPAFLNV

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Fusion Gene PPI Analysis for OLA1-SUN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for OLA1-SUN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for OLA1-SUN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource