Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ARHGAP6-MBD1 (FusionGDB2 ID:6151)

Fusion Gene Summary for ARHGAP6-MBD1

Fusion gene summary

Fusion gene information	Fusion gene name: ARHGAP6-MBD1
	Fusion gene ID: 6151
		Hgene	Tgene
	Gene symbol	ARHGAP6	MBD1
	Gene ID	395	4152
	Gene name	Rho GTPase activating protein 6	methyl-CpG binding domain protein 1
	Synonyms	RHOGAP6\|RHOGAPX-1	CXXC3\|PCM1\|RFT
	Cytomap	Xp22.2	18q21.1
	Type of gene	protein-coding	protein-coding
	Description	rho GTPase-activating protein 6Rho-type GTPase-activating protein RhoGAPX-1rho-type GTPase-activating protein 6	methyl-CpG-binding domain protein 1CXXC-type zinc finger protein 3methyl-CpG binding domain protein 1 isoform PCM1protein containing methyl-CpG-binding domain 1the regulator of fibroblast growth factor 2 (FGF-2) transcription
	Modification date	20200313	20200313
	UniProtAcc	O43182	Q9UIS9
	Ensembl transtripts involved in fusion gene	ENST00000303025, ENST00000337414, ENST00000380718, ENST00000380732, ENST00000380736, ENST00000413512, ENST00000491514, ENST00000534860,	ENST00000339998, ENST00000591416, ENST00000269468, ENST00000269471, ENST00000347968, ENST00000349085, ENST00000353909, ENST00000382948, ENST00000398488, ENST00000398493, ENST00000398495, ENST00000424334, ENST00000436910, ENST00000457839, ENST00000585595, ENST00000585672, ENST00000587605, ENST00000588937, ENST00000590208, ENST00000591535,
Fusion gene scores	* DoF score	5 X 5 X 3=75	3 X 3 X 2=18
	# samples	6	3
	** MAII score	log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ARHGAP6 [Title/Abstract] AND MBD1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ARHGAP6(11679223)-MBD1(47796443), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ARHGAP6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MBD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	AK027253	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-

Top

Fusion Gene ORF analysis for ARHGAP6-MBD1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000303025	ENST00000339998	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-3UTR	ENST00000303025	ENST00000591416	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-3UTR	ENST00000337414	ENST00000339998	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-3UTR	ENST00000337414	ENST00000591416	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-3UTR	ENST00000380718	ENST00000339998	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-3UTR	ENST00000380718	ENST00000591416	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-3UTR	ENST00000380732	ENST00000339998	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-3UTR	ENST00000380732	ENST00000591416	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-3UTR	ENST00000380736	ENST00000339998	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-3UTR	ENST00000380736	ENST00000591416	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-3UTR	ENST00000413512	ENST00000339998	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-3UTR	ENST00000413512	ENST00000591416	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-3UTR	ENST00000491514	ENST00000339998	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-3UTR	ENST00000491514	ENST00000591416	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-3UTR	ENST00000534860	ENST00000339998	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-3UTR	ENST00000534860	ENST00000591416	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000303025	ENST00000269468	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000303025	ENST00000269471	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000303025	ENST00000347968	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000303025	ENST00000349085	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000303025	ENST00000353909	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000303025	ENST00000382948	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000303025	ENST00000398488	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000303025	ENST00000398493	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000303025	ENST00000398495	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000303025	ENST00000424334	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000303025	ENST00000436910	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000303025	ENST00000457839	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000303025	ENST00000585595	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000303025	ENST00000585672	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000303025	ENST00000587605	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000303025	ENST00000588937	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000303025	ENST00000590208	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000303025	ENST00000591535	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000337414	ENST00000269468	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000337414	ENST00000269471	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000337414	ENST00000347968	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000337414	ENST00000349085	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000337414	ENST00000353909	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000337414	ENST00000382948	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000337414	ENST00000398488	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000337414	ENST00000398493	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000337414	ENST00000398495	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000337414	ENST00000424334	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000337414	ENST00000436910	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000337414	ENST00000457839	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000337414	ENST00000585595	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000337414	ENST00000585672	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000337414	ENST00000587605	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000337414	ENST00000588937	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000337414	ENST00000590208	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000337414	ENST00000591535	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380718	ENST00000269468	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380718	ENST00000269471	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380718	ENST00000347968	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380718	ENST00000349085	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380718	ENST00000353909	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380718	ENST00000382948	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380718	ENST00000398488	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380718	ENST00000398493	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380718	ENST00000398495	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380718	ENST00000424334	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380718	ENST00000436910	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380718	ENST00000457839	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380718	ENST00000585595	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380718	ENST00000585672	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380718	ENST00000587605	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380718	ENST00000588937	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380718	ENST00000590208	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380718	ENST00000591535	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380732	ENST00000269468	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380732	ENST00000269471	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380732	ENST00000347968	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380732	ENST00000349085	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380732	ENST00000353909	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380732	ENST00000382948	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380732	ENST00000398488	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380732	ENST00000398493	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380732	ENST00000398495	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380732	ENST00000424334	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380732	ENST00000436910	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380732	ENST00000457839	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380732	ENST00000585595	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380732	ENST00000585672	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380732	ENST00000587605	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380732	ENST00000588937	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380732	ENST00000590208	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380732	ENST00000591535	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380736	ENST00000269468	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380736	ENST00000269471	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380736	ENST00000347968	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380736	ENST00000349085	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380736	ENST00000353909	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380736	ENST00000382948	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380736	ENST00000398488	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380736	ENST00000398493	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380736	ENST00000398495	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380736	ENST00000424334	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380736	ENST00000436910	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380736	ENST00000457839	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380736	ENST00000585595	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380736	ENST00000585672	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380736	ENST00000587605	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380736	ENST00000588937	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380736	ENST00000590208	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000380736	ENST00000591535	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000413512	ENST00000269468	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000413512	ENST00000269471	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000413512	ENST00000347968	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000413512	ENST00000349085	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000413512	ENST00000353909	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000413512	ENST00000382948	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000413512	ENST00000398488	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000413512	ENST00000398493	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000413512	ENST00000398495	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000413512	ENST00000424334	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000413512	ENST00000436910	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000413512	ENST00000457839	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000413512	ENST00000585595	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000413512	ENST00000585672	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000413512	ENST00000587605	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000413512	ENST00000588937	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000413512	ENST00000590208	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000413512	ENST00000591535	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000491514	ENST00000269468	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000491514	ENST00000269471	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000491514	ENST00000347968	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000491514	ENST00000349085	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000491514	ENST00000353909	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000491514	ENST00000382948	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000491514	ENST00000398488	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000491514	ENST00000398493	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000491514	ENST00000398495	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000491514	ENST00000424334	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000491514	ENST00000436910	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000491514	ENST00000457839	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000491514	ENST00000585595	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000491514	ENST00000585672	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000491514	ENST00000587605	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000491514	ENST00000588937	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000491514	ENST00000590208	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000491514	ENST00000591535	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000534860	ENST00000269468	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000534860	ENST00000269471	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000534860	ENST00000347968	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000534860	ENST00000349085	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000534860	ENST00000353909	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000534860	ENST00000382948	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000534860	ENST00000398488	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000534860	ENST00000398493	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000534860	ENST00000398495	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000534860	ENST00000424334	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000534860	ENST00000436910	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000534860	ENST00000457839	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000534860	ENST00000585595	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000534860	ENST00000585672	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000534860	ENST00000587605	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000534860	ENST00000588937	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000534860	ENST00000590208	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-
intron-intron	ENST00000534860	ENST00000591535	ARHGAP6	chrX	11679223	-	MBD1	chr18	47796443	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for ARHGAP6-MBD1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ARHGAP6-MBD1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:11679223/:47796443)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ARHGAP6 O43182	MBD1 Q9UIS9
FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269\|PubMed:10699171}.	FUNCTION: Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. {ECO:0000269\|PubMed:10454587, ECO:0000269\|PubMed:10648624, ECO:0000269\|PubMed:12665582, ECO:0000269\|PubMed:12697822, ECO:0000269\|PubMed:12711603, ECO:0000269\|PubMed:14555760, ECO:0000269\|PubMed:14610093, ECO:0000269\|PubMed:9207790, ECO:0000269\|PubMed:9774669}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for ARHGAP6-MBD1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for ARHGAP6-MBD1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ARHGAP6-MBD1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ARHGAP6-MBD1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source