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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:OPA3-TNPO1 (FusionGDB2 ID:61533)

Fusion Gene Summary for OPA3-TNPO1

check button Fusion gene summary
Fusion gene informationFusion gene name: OPA3-TNPO1
Fusion gene ID: 61533
HgeneTgene
Gene symbol

OPA3

TNPO1

Gene ID

80207

3842

Gene nameouter mitochondrial membrane lipid metabolism regulator OPA3transportin 1
SynonymsMGA3IPO2|KPNB2|MIP|MIP1|TRN
Cytomap

19q13.32

5q13.2

Type of geneprotein-codingprotein-coding
Descriptionoptic atrophy 3 proteinOPA3 outer mitochondrial membrane lipid metabolism regulatorOptic atrophy 3 (Iraqi-Jewish 'optic atrophy plus')optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)transportin-1M9 region interaction proteinimportin 2importin beta 2karyopherin (importin) beta 2karyopherin beta-2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000263275, ENST00000323060, 
ENST00000544371, 		ENST00000513944, 
ENST00000447967, ENST00000506351, 
ENST00000523768, ENST00000337273, 
ENST00000454282, 
Fusion gene scores* DoF score6 X 4 X 5=1208 X 8 X 5=320
# samples 78
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/320*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OPA3 [Title/Abstract] AND TNPO1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointOPA3(46087881)-TNPO1(72144212), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTNPO1

GO:0006606

protein import into nucleus

9144189


check buttonFusion gene breakpoints across OPA3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TNPO1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4READTCGA-EI-7002-01AOPA3chr19

46087881

-TNPO1chr5

72144212

+
ChimerDB4READTCGA-EI-7002OPA3chr19

46087881

-TNPO1chr5

72144212

+


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Fusion Gene ORF analysis for OPA3-TNPO1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000263275ENST00000513944OPA3chr19

46087881

-TNPO1chr5

72144212

+
5CDS-3UTRENST00000323060ENST00000513944OPA3chr19

46087881

-TNPO1chr5

72144212

+
5CDS-5UTRENST00000263275ENST00000447967OPA3chr19

46087881

-TNPO1chr5

72144212

+
5CDS-5UTRENST00000263275ENST00000506351OPA3chr19

46087881

-TNPO1chr5

72144212

+
5CDS-5UTRENST00000263275ENST00000523768OPA3chr19

46087881

-TNPO1chr5

72144212

+
5CDS-5UTRENST00000323060ENST00000447967OPA3chr19

46087881

-TNPO1chr5

72144212

+
5CDS-5UTRENST00000323060ENST00000506351OPA3chr19

46087881

-TNPO1chr5

72144212

+
5CDS-5UTRENST00000323060ENST00000523768OPA3chr19

46087881

-TNPO1chr5

72144212

+
In-frameENST00000263275ENST00000337273OPA3chr19

46087881

-TNPO1chr5

72144212

+
In-frameENST00000263275ENST00000454282OPA3chr19

46087881

-TNPO1chr5

72144212

+
In-frameENST00000323060ENST00000337273OPA3chr19

46087881

-TNPO1chr5

72144212

+
In-frameENST00000323060ENST00000454282OPA3chr19

46087881

-TNPO1chr5

72144212

+
intron-3CDSENST00000544371ENST00000337273OPA3chr19

46087881

-TNPO1chr5

72144212

+
intron-3CDSENST00000544371ENST00000454282OPA3chr19

46087881

-TNPO1chr5

72144212

+
intron-3UTRENST00000544371ENST00000513944OPA3chr19

46087881

-TNPO1chr5

72144212

+
intron-5UTRENST00000544371ENST00000447967OPA3chr19

46087881

-TNPO1chr5

72144212

+
intron-5UTRENST00000544371ENST00000506351OPA3chr19

46087881

-TNPO1chr5

72144212

+
intron-5UTRENST00000544371ENST00000523768OPA3chr19

46087881

-TNPO1chr5

72144212

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000323060OPA3chr1946087881-ENST00000337273TNPO1chr572144212+109622201452901918
ENST00000323060OPA3chr1946087881-ENST00000454282TNPO1chr572144212+84672201452751868
ENST00000263275OPA3chr1946087881-ENST00000337273TNPO1chr572144212+109391971222878918
ENST00000263275OPA3chr1946087881-ENST00000454282TNPO1chr572144212+84441971222728868

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000323060ENST00000337273OPA3chr1946087881-TNPO1chr572144212+6.61E-050.99993396
ENST00000323060ENST00000454282OPA3chr1946087881-TNPO1chr572144212+9.67E-050.9999033
ENST00000263275ENST00000337273OPA3chr1946087881-TNPO1chr572144212+6.59E-050.9999341
ENST00000263275ENST00000454282OPA3chr1946087881-TNPO1chr572144212+9.65E-050.99990344

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Fusion Genomic Features for OPA3-TNPO1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
OPA3chr1946087880-TNPO1chr572144211+1.26E-101
OPA3chr1946087880-TNPO1chr572144211+1.26E-101
OPA3chr1946087880-TNPO1chr572144211+1.26E-101
OPA3chr1946087880-TNPO1chr572144211+1.26E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for OPA3-TNPO1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:46087881/chr5:72144212)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTNPO1chr19:46087881chr5:72144212ENST00000337273025358_37653427.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneTNPO1chr19:46087881chr5:72144212ENST00000454282024358_37652688.3333333333335Compositional biasNote=Asp/Glu-rich (acidic)
TgeneTNPO1chr19:46087881chr5:72144212ENST00000506351025358_3760949.3333333333334Compositional biasNote=Asp/Glu-rich (acidic)
TgeneTNPO1chr19:46087881chr5:72144212ENST00000523768023358_3765849.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneTNPO1chr19:46087881chr5:72144212ENST0000033727302541_10953427.0DomainImportin N-terminal
TgeneTNPO1chr19:46087881chr5:72144212ENST0000045428202441_10952688.3333333333335DomainImportin N-terminal
TgeneTNPO1chr19:46087881chr5:72144212ENST0000050635102541_1090949.3333333333334DomainImportin N-terminal
TgeneTNPO1chr19:46087881chr5:72144212ENST0000052376802341_1095849.0DomainImportin N-terminal
TgeneTNPO1chr19:46087881chr5:72144212ENST00000337273025137_17453427.0RepeatHEAT 4
TgeneTNPO1chr19:46087881chr5:72144212ENST00000337273025181_21153427.0RepeatHEAT 5
TgeneTNPO1chr19:46087881chr5:72144212ENST0000033727302519_4653427.0RepeatHEAT 1
TgeneTNPO1chr19:46087881chr5:72144212ENST00000337273025224_25153427.0RepeatHEAT 6
TgeneTNPO1chr19:46087881chr5:72144212ENST00000337273025263_29053427.0RepeatHEAT 7
TgeneTNPO1chr19:46087881chr5:72144212ENST00000337273025306_39753427.0RepeatHEAT 8
TgeneTNPO1chr19:46087881chr5:72144212ENST00000337273025405_43353427.0RepeatHEAT 9
TgeneTNPO1chr19:46087881chr5:72144212ENST00000337273025445_47253427.0RepeatHEAT 10
TgeneTNPO1chr19:46087881chr5:72144212ENST00000337273025486_51953427.0RepeatHEAT 11
TgeneTNPO1chr19:46087881chr5:72144212ENST0000033727302551_8953427.0RepeatHEAT 2
TgeneTNPO1chr19:46087881chr5:72144212ENST00000337273025527_56053427.0RepeatHEAT 12
TgeneTNPO1chr19:46087881chr5:72144212ENST00000337273025568_60653427.0RepeatHEAT 13
TgeneTNPO1chr19:46087881chr5:72144212ENST00000337273025614_66553427.0RepeatHEAT 14
TgeneTNPO1chr19:46087881chr5:72144212ENST00000337273025676_70753427.0RepeatHEAT 15
TgeneTNPO1chr19:46087881chr5:72144212ENST00000337273025715_74853427.0RepeatHEAT 16
TgeneTNPO1chr19:46087881chr5:72144212ENST00000337273025756_79153427.0RepeatHEAT 17
TgeneTNPO1chr19:46087881chr5:72144212ENST00000337273025799_83253427.0RepeatHEAT 18
TgeneTNPO1chr19:46087881chr5:72144212ENST00000337273025841_87253427.0RepeatHEAT 19
TgeneTNPO1chr19:46087881chr5:72144212ENST00000337273025875_89553427.0RepeatHEAT 20
TgeneTNPO1chr19:46087881chr5:72144212ENST0000033727302598_13153427.0RepeatHEAT 3
TgeneTNPO1chr19:46087881chr5:72144212ENST00000454282024137_17452688.3333333333335RepeatHEAT 4
TgeneTNPO1chr19:46087881chr5:72144212ENST00000454282024181_21152688.3333333333335RepeatHEAT 5
TgeneTNPO1chr19:46087881chr5:72144212ENST0000045428202419_4652688.3333333333335RepeatHEAT 1
TgeneTNPO1chr19:46087881chr5:72144212ENST00000454282024224_25152688.3333333333335RepeatHEAT 6
TgeneTNPO1chr19:46087881chr5:72144212ENST00000454282024263_29052688.3333333333335RepeatHEAT 7
TgeneTNPO1chr19:46087881chr5:72144212ENST00000454282024306_39752688.3333333333335RepeatHEAT 8
TgeneTNPO1chr19:46087881chr5:72144212ENST00000454282024405_43352688.3333333333335RepeatHEAT 9
TgeneTNPO1chr19:46087881chr5:72144212ENST00000454282024445_47252688.3333333333335RepeatHEAT 10
TgeneTNPO1chr19:46087881chr5:72144212ENST00000454282024486_51952688.3333333333335RepeatHEAT 11
TgeneTNPO1chr19:46087881chr5:72144212ENST0000045428202451_8952688.3333333333335RepeatHEAT 2
TgeneTNPO1chr19:46087881chr5:72144212ENST00000454282024527_56052688.3333333333335RepeatHEAT 12
TgeneTNPO1chr19:46087881chr5:72144212ENST00000454282024568_60652688.3333333333335RepeatHEAT 13
TgeneTNPO1chr19:46087881chr5:72144212ENST00000454282024614_66552688.3333333333335RepeatHEAT 14
TgeneTNPO1chr19:46087881chr5:72144212ENST00000454282024676_70752688.3333333333335RepeatHEAT 15
TgeneTNPO1chr19:46087881chr5:72144212ENST00000454282024715_74852688.3333333333335RepeatHEAT 16
TgeneTNPO1chr19:46087881chr5:72144212ENST00000454282024756_79152688.3333333333335RepeatHEAT 17
TgeneTNPO1chr19:46087881chr5:72144212ENST00000454282024799_83252688.3333333333335RepeatHEAT 18
TgeneTNPO1chr19:46087881chr5:72144212ENST00000454282024841_87252688.3333333333335RepeatHEAT 19
TgeneTNPO1chr19:46087881chr5:72144212ENST00000454282024875_89552688.3333333333335RepeatHEAT 20
TgeneTNPO1chr19:46087881chr5:72144212ENST0000045428202498_13152688.3333333333335RepeatHEAT 3
TgeneTNPO1chr19:46087881chr5:72144212ENST00000506351025137_1740949.3333333333334RepeatHEAT 4
TgeneTNPO1chr19:46087881chr5:72144212ENST00000506351025181_2110949.3333333333334RepeatHEAT 5
TgeneTNPO1chr19:46087881chr5:72144212ENST0000050635102519_460949.3333333333334RepeatHEAT 1
TgeneTNPO1chr19:46087881chr5:72144212ENST00000506351025224_2510949.3333333333334RepeatHEAT 6
TgeneTNPO1chr19:46087881chr5:72144212ENST00000506351025263_2900949.3333333333334RepeatHEAT 7
TgeneTNPO1chr19:46087881chr5:72144212ENST00000506351025306_3970949.3333333333334RepeatHEAT 8
TgeneTNPO1chr19:46087881chr5:72144212ENST00000506351025405_4330949.3333333333334RepeatHEAT 9
TgeneTNPO1chr19:46087881chr5:72144212ENST00000506351025445_4720949.3333333333334RepeatHEAT 10
TgeneTNPO1chr19:46087881chr5:72144212ENST00000506351025486_5190949.3333333333334RepeatHEAT 11
TgeneTNPO1chr19:46087881chr5:72144212ENST0000050635102551_890949.3333333333334RepeatHEAT 2
TgeneTNPO1chr19:46087881chr5:72144212ENST00000506351025527_5600949.3333333333334RepeatHEAT 12
TgeneTNPO1chr19:46087881chr5:72144212ENST00000506351025568_6060949.3333333333334RepeatHEAT 13
TgeneTNPO1chr19:46087881chr5:72144212ENST00000506351025614_6650949.3333333333334RepeatHEAT 14
TgeneTNPO1chr19:46087881chr5:72144212ENST00000506351025676_7070949.3333333333334RepeatHEAT 15
TgeneTNPO1chr19:46087881chr5:72144212ENST00000506351025715_7480949.3333333333334RepeatHEAT 16
TgeneTNPO1chr19:46087881chr5:72144212ENST00000506351025756_7910949.3333333333334RepeatHEAT 17
TgeneTNPO1chr19:46087881chr5:72144212ENST00000506351025799_8320949.3333333333334RepeatHEAT 18
TgeneTNPO1chr19:46087881chr5:72144212ENST00000506351025841_8720949.3333333333334RepeatHEAT 19
TgeneTNPO1chr19:46087881chr5:72144212ENST00000506351025875_8950949.3333333333334RepeatHEAT 20
TgeneTNPO1chr19:46087881chr5:72144212ENST0000050635102598_1310949.3333333333334RepeatHEAT 3
TgeneTNPO1chr19:46087881chr5:72144212ENST00000523768023137_1745849.0RepeatHEAT 4
TgeneTNPO1chr19:46087881chr5:72144212ENST00000523768023181_2115849.0RepeatHEAT 5
TgeneTNPO1chr19:46087881chr5:72144212ENST0000052376802319_465849.0RepeatHEAT 1
TgeneTNPO1chr19:46087881chr5:72144212ENST00000523768023224_2515849.0RepeatHEAT 6
TgeneTNPO1chr19:46087881chr5:72144212ENST00000523768023263_2905849.0RepeatHEAT 7
TgeneTNPO1chr19:46087881chr5:72144212ENST00000523768023306_3975849.0RepeatHEAT 8
TgeneTNPO1chr19:46087881chr5:72144212ENST00000523768023405_4335849.0RepeatHEAT 9
TgeneTNPO1chr19:46087881chr5:72144212ENST00000523768023445_4725849.0RepeatHEAT 10
TgeneTNPO1chr19:46087881chr5:72144212ENST00000523768023486_5195849.0RepeatHEAT 11
TgeneTNPO1chr19:46087881chr5:72144212ENST0000052376802351_895849.0RepeatHEAT 2
TgeneTNPO1chr19:46087881chr5:72144212ENST00000523768023527_5605849.0RepeatHEAT 12
TgeneTNPO1chr19:46087881chr5:72144212ENST00000523768023568_6065849.0RepeatHEAT 13
TgeneTNPO1chr19:46087881chr5:72144212ENST00000523768023614_6655849.0RepeatHEAT 14
TgeneTNPO1chr19:46087881chr5:72144212ENST00000523768023676_7075849.0RepeatHEAT 15
TgeneTNPO1chr19:46087881chr5:72144212ENST00000523768023715_7485849.0RepeatHEAT 16
TgeneTNPO1chr19:46087881chr5:72144212ENST00000523768023756_7915849.0RepeatHEAT 17
TgeneTNPO1chr19:46087881chr5:72144212ENST00000523768023799_8325849.0RepeatHEAT 18
TgeneTNPO1chr19:46087881chr5:72144212ENST00000523768023841_8725849.0RepeatHEAT 19
TgeneTNPO1chr19:46087881chr5:72144212ENST00000523768023875_8955849.0RepeatHEAT 20
TgeneTNPO1chr19:46087881chr5:72144212ENST0000052376802398_1315849.0RepeatHEAT 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneOPA3chr19:46087881chr5:72144212ENST00000263275-12103_16347180.0Coiled coilOntology_term=ECO:0000255
HgeneOPA3chr19:46087881chr5:72144212ENST00000323060-12103_16347181.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for OPA3-TNPO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>61533_61533_1_OPA3-TNPO1_OPA3_chr19_46087881_ENST00000263275_TNPO1_chr5_72144212_ENST00000337273_length(transcript)=10939nt_BP=197nt
GTTGAGGCGCCCCGCCCAGTCAGCAAGGTTGCGCGTGCCCTGTGAGACCGCCAAGATGGTGGTGGGCGCGTTCCCTATGGCGAAGCTGCT
ATACTTGGGCATCCGGCAGGTCAGCAAGCCGCTTGCCAACCGTATTAAGGAGGCCGCCCGCCGAAGCGAGTTCTTCAAGACCTATATCTG
CCTCCCGCCGGCTCAACCAAACCAAGATGGAGTATGAGTGGAAACCTGACGAGCAAGGGCTTCAGCAAATCCTGCAGCTGTTGAAGGAGT
CCCAGTCCCCAGACACCACCATCCAGAGAACCGTGCAACAAAAACTGGAACAACTTAATCAGTATCCAGACTTTAACAACTACTTGATTT
TTGTTCTTACAAAATTAAAATCTGAAGATGAACCCACAAGATCATTGAGTGGTCTTATCTTGAAGAATAATGTGAAAGCACACTTTCAGA
ACTTCCCAAATGGTGTAACAGACTTTATTAAAAGTGAATGTTTAAATAATATTGGTGACTCCTCTCCTCTGATTAGAGCCACTGTTGGTA
TTTTGATCACAACTATAGCCTCCAAGGGAGAATTGCAGAATTGGCCTGACCTCTTACCAAAACTCTGTAGCCTGTTGGATTCTGAAGATT
ATAATACCTGTGAGGGAGCATTTGGTGCCCTTCAGAAGATTTGTGAAGATTCTGCTGAGATTTTAGACAGTGATGTTTTAGATCGTCCTC
TCAACATCATGATTCCCAAATTTTTACAGTTCTTCAAGCATAGTAGTCCAAAAATAAGGTCTCACGCTGTTGCATGTGTCAATCAGTTTA
TCATCAGTAGGACTCAAGCTCTAATGTTGCACATTGATTCTTTTATTGAGAATCTCTTTGCATTAGCTGGTGATGAAGAACCAGAGGTAC
GGAAAAATGTGTGCCGAGCACTTGTGATGTTGCTCGAAGTTCGAATGGATCGCCTGCTTCCTCACATGCATAATATAGTTGAGTACATGC
TACAGAGGACTCAAGATCAAGATGAAAATGTGGCTTTAGAAGCCTGTGAATTTTGGCTAACTTTAGCTGAACAGCCAATATGCAAAGATG
TACTCGTAAGGCATCTTCCTAAGTTGATTCCTGTGTTAGTGAATGGCATGAAGTACTCAGACATAGATATTATCCTACTTAAGGGTGATG
TTGAAGAAGACGAAACGATTCCTGATAGTGAACAGGATATACGGCCACGTTTTCACCGATCGAGGACGGTGGCTCAGCAGCATGATGAAG
ATGGAATTGAAGAGGAAGATGATGATGATGATGAAATTGATGATGATGATACAATTTCTGACTGGAATCTAAGAAAATGTTCTGCTGCTG
CCCTGGATGTTCTTGCAAATGTGTATCGTGATGAACTGCTGCCACATATTTTGCCCCTTTTGAAAGAATTACTTTTTCATCATGAATGGG
TTGTTAAAGAATCAGGCATTTTGGTTTTAGGAGCAATTGCTGAAGGTTGCATGCAGGGCATGATTCCATACTTGCCTGAGCTTATTCCTC
ACCTTATTCAGTGCCTCTCTGATAAAAAGGCTCTTGTGCGTTCCATAACATGCTGGACTCTTAGCCGCTATGCACACTGGGTGGTCAGCC
AGCCGCCAGACACGTACCTGAAGCCATTAATGACAGAATTGCTAAAGCGCATCCTGGACAGCAACAAGAGAGTACAAGAAGCTGCCTGCA
GTGCCTTTGCTACCCTAGAAGAGGAGGCTTGTACAGAACTTGTTCCTTACCTTGCTTATATACTTGATACCCTGGTCTTTGCATTTAGTA
AATACCAGCATAAGAACCTGCTCATTCTTTACGATGCCATAGGAACATTAGCAGATTCAGTAGGACATCATTTAAACAAACCAGAATATA
TTCAGATGCTAATGCCTCCACTGATCCAGAAATGGAACATGTTAAAGGATGAAGATAAAGATCTCTTCCCTTTACTTGAGTGCCTATCTT
CAGTTGCCACAGCACTGCAGTCTGGATTCCTTCCGTACTGTGAACCTGTGTATCAGCGTTGTGTAAACCTAGTACAGAAGACTCTTGCAC
AAGCCATGCTAAACAATGCTCAACCAGATCAATATGAAGCTCCAGATAAAGATTTTATGATAGTGGCTCTTGATTTACTGAGTGGCCTGG
CTGAAGGACTTGGAGGCAACATTGAACAGCTGGTAGCCCGAAGTAACATCCTGACACTAATGTATCAGTGCATGCAGGATAAAATGCCAG
AAGTTCGACAGAGTTCTTTTGCCCTGTTAGGTGACCTCACAAAAGCTTGCTTTCAGCATGTTAAGCCTTGTATAGCTGATTTCATGCCAA
TATTGGGAACCAACCTAAATCCAGAATTCATTTCAGTCTGCAACAATGCCACATGGGCAATTGGAGAAATCTCCATTCAAATGGGTATAG
AGATGCAGCCTTATATTCCTATGGTGTTGCACCAGCTTGTAGAAATCATTAACAGACCCAACACACCAAAGACGTTGTTAGAGAATACAG
CAATAACAATTGGTCGTCTTGGTTACGTTTGTCCTCAAGAGGTGGCCCCCATGCTACAGCAGTTTATAAGACCCTGGTGCACCTCTCTGA
GAAACATAAGAGACAATGAGGAAAAGGATTCAGCATTCCGTGGAATTTGTACCATGATCAGTGTGAATCCCAGTGGCGTAATCCAAGATT
TTATATTTTTTTGTGATGCCGTTGCATCATGGATTAACCCAAAAGATGATCTCAGAGACATGTTCTGTAAGATCCTTCATGGATTTAAAA
ATCAAGTTGGCGATGAAAATTGGAGGCGTTTCTCTGACCAGTTTCCTCTTCCCTTAAAAGAGCGTCTTGCAGCTTTTTATGGTGTTTAAT
CTAATACACTTAAGCTGCAGTCCCAAAATTAGGGGTCCTTCAGTCTTGGAGACTATAAGGGAGCCTCTGCACCCAGGGAAAATGTTACCC
TTTACAGGGGGGAAGGGTAAACCAGTAGGGAATACAGTACAATCCCAACCCTACTGGGAGGGGCGGGAGGGAGGTGTTGCCGTCACTGTA
TTAAGTCGATGTTGGGAAACGTTTTAACATCTGGAGCCTTTGTGGGTGGAAATATGTCTCCAGTTACAACTCCGCAGTGGATGTGAAGAA
GCAAAAAAAAAAAAATCTATTCAGTCTACTCACAAAACAGTACATTGTGGAATATTATGGGGAATTGTACCAAAACAAGAACCATATAAA
TGATGCCTAGGGACAAGAAAGAGGAACAATTCTATAGCGCACAATAAAGGAAACCTAAGAATGGGAGTTACAAATAGTAAAGAAGCTTTT
TTTTTTTTTTTAATTTAAAGTTTTTTTATGTAAGTTTTCCCACATGATGGGGCCTTGTTTTGCATGTTGATGAAGAACTACACAAAGAAA
ACTAATATAGTTAAAAGTCAGCTTGCCTTCCCGTAGTAGAAGCAGGTTCTTGGAAGTTACAATTTAAGGTACCCCAAAAAAGTTGGAAAT
AAAACAAAACAAACATAAACAATGAAGCACCCTGTGAAATGCCAAATGAGTCACTCCTTTTACCTTTTTTGGGGTGGGCAGGGAGGGAGG
AATAAATGGGGTTGGGCATATCAAACTAAAGATGACATCTTAATTTTGCATTGAACATTAATGTAGCGGATATAATTTGATGATTATACT
TCATTAGATTTAATTTCTAGGCCAAGATGTTACTTTTTAAAGTGCAGTTTAAGGTTCAGGCATGCATTCTGGCTCATAGTGGTTGAAAGT
AATTTAAATTAGTGGGAAAGTAGCATGCTTGCATCACATAGAGTGAGATTGGTATTCATTTACCTATGTTGCGCCAGTTTGTGTTGCAGT
TTACCAATTCAATATAGCCCTGCATTTAAAGTTCCTTTTTAAGATTTGTGGATTTTATTTTTATTAAGAACATAGATATATAAAGTACTG
TAGTTTACAGGTAGGCCTTGAAATATCTTTTTTAGGATCTGTTAGGAATAAGATTGATATTGTATTGTGTGTAACCTGCACAATGTGGAA
AGCTGATATACCTGTGCAAAATCTTTGCCTCTGTGCTGTCAGTGTGATGTGCTTTCTGCATGGTTATATACTACTAGTGATTTTATCAAA
ACTTCTAAAATTTAAATTACGTGGTAAAAGATCTGTAAAAGGCTGCATAAATGTTAGTTGGCACATAAAGACAATTGTAGAAGTTGAAAA
ATGATTGCTATATTTCAATGTTTATTCCCACTCAACATACTGCCTTCTAAGCTTCCCTTTTTTTGTTCAAAGCATGATCTTAAAGATATG
TTTAAGTTAATGGATGTAATGCAGGGTTCCTACACTGTATTTTGGCGCATGTTGGTGGCCCTCTGTGCCCTAGATATATGCACACAGGGT
GCAAGTTAAAAGCTACAGAGTGAAAGTTGGTTTGGATCCTCTTCATTTCATTTGTTTAGCTTTTCTGTTATTTTTCTCTACTTACATGTA
TTCCTGTGAATAAATCCTTGTTAAGTTAACCCTTTACTTTTCCTTCCATGTGTATTTTCTTATATACTGTGAATGTGAAAACCTAACTGG
TACACTTGATCTTGTGTTCATATGAAAGTGCAAGTCTTTATTAATTTGGATTGCCTGAACAGTGTATCCCATGATGATGAAGGAAAATGG
AGAGATTTTTCTTTTTAACTCTGCTGGTCAGAGATGAAGCCACGCCTTTCCATTTTTCAATGCTGCATATTTAATCTGCAACAAAAATGT
TAAGCCATAACAGCCTTTTTATATTTTAGTTTGTCACCTTTGCATTGCAGAATAAATACTGAATAACCATTTTTATAAGCAGTTGCTCCT
CTTTGCATGGTTCTATTCTCTAAAAGTGTTGAATGATACAGCCATTGCACTGAAGTTTGAGCTGTGTGCGTGTGAATTTATACTGTTTCA
AAAATTTCAAATGCATGGTAGCATGTAGAAAGGTTTTTGTTACTATGTGTGTGTGTGTGTTTTGTTTTGTTTTGTTCTGTTTTTTAACGT
TCTTTCACCTTTCCTCTACTTTGGCTTTGCAAATTTCAGTCTGTAGAGCCTGAAATTAAATTATTTTATAGTGCCTGATATTTTTAATAT
TATAAGTTGGATTCAAAGGGTATACAGCATTTTGTTTTCTAGTACCATTGCTTCACTGGGAGCTCAAAATTTGCCTCCCTGTTAGTCTTT
AATAACTGAGTAGAGTAGCTTTTTTATTCTTAGATTATAGTGATATTCTGTAGTGCTTCAAATACTTAGAATTCTAATATGAGAGATAGT
TTAATATTCTGGAATAGAGAGTATTTTAAATTGAAATGACCAAATTCGATTTAAAACAAACACATAACAATCTTCAGTAAAGTTATTTGA
ACCTGTGGTTGACAATTCTGTATTGACTAAAGGCAATATTGTCACCTGTCTCATTAAAAATTAGTTTCCAGTTAGGCAGATGAATAACAC
TATTAAAAATGCACCCAGTTTTGTAGTCACTTGACTTTTTTTTTTTATTTAAATGAAATTTAATTTGAAAATAGAAAATAAAATTAGGTA
AATATGACTGGCAACCTGAATTTGAGTTGGGATTCTTTGTGTATTTTTCCCCCTTGAGGTTATTGTTTCTTCCTAATTTATATTTCAGAT
ACATAGTGTAGAACAGGAATTTGCAGAAGCCATTTAAGTTATCTTTTGAGGTAAGCTCTGATTTAGCATTTATTCTGATAAAATCTAATA
CATCATGGGATATATATAAAGCAACTTAATTCTTGTGGTGTAGTCTTAATAGTTTTGAATGTTGACTGAATGTCTATAAAATTGTGAGTT
TGTCTTTGTTACATTCCAGTGTTTCTGCCTCTTGGCATGCTTAAAGCACGGCTTACTTCATCTGCTCCTTACACACTAAAATGCTGTTAG
TGTGCTCAACTACAGAAATAGCCGCTGCTAAGTGATGTAGATTTTCTACTTGAATATTTTTATGTTGTAGGAACCTCAGGAGGTCAGTGT
TTACTGTTTTATATATGCCTTCTTTTTCCTGTTTGAGCTTCTCTCTTTGAAGGATTCTAACAGAACAAAGCTGCTGATCAACCTAAGTTG
GAAACAGAAAGTGTAATTAATATAACTTAAATGCATGTTTGGCAGTTCCATGTTACAGTCCATTAGCGAGTGAACTTAGTGCCACAGGTA
TTCATTTATTCAGGAAAGAATTTTGCTTTTTGTATTGTCTAATCTCTTCAATGACTTCATACTGTGTAAAAAAAAATCACTTTTTAATAT
TTTTTGGTTGGTTATTTCCCAAATAATCAACATGTAAATAATCTTTTAAGAGCCAGTTCTGATGCTTTACATTATTGCTACTTGATTTTG
TTATGCAAGTTAGATTTCAGAAGAATAGATTTTAAAACACTTAACCAAGCCATTACATCTTAAAAACAAAACAAGTAGCATACATTTTGT
AATTAACATTGATAAACACTGTGATTTTTTTGGTTAAGACTTTTTCATTGATCTGAATTGCTTAAATTGCATATATTGTAAAATAGGATC
AGATGTATATTTTAAACTAATTTCAATGGATTTTCCTCTTGAAATGCTTTGTCTACTCAGTTATAAAATATTCAGATACAAGTTTTATCT
CAGGTGAATACTCTTGTATTGTTTTTGCTTTGGTGACATGCTTATAAAGGGTCATCCTAGTTACATTCTTTGTTTTTTAAGTGTATTTCA
TTGAGAATCTTTCCATTTAGTCTGATTTTTTTCCTAATATTCTAGCAGGCTGGGGTGGTATAAAGCCCTCCTGACAAGCCTTTTGCCTAC
AGGTTTACCTGAAAATGAGCTACATATGGTCGTCATTTTCTTCAAACTCTCAAAATAGGAAAGTGGAAATTTTTCTCCCCTATATAAAAT
TATTCTGCCTAGCAGAAATGCCAGAAATAAATTAATTGCATCTTAGTCTAAATTTAAGTCCTTTGCCATGAGGAAAAAGTGGTTTTTTGC
TTCATATGGTAAATCTATATTATTCATATTGAATGTATTAACAGATAATGGTGCAAAAGCATTCTTCCCAGGGGAAGAGTGTATCATGCA
TAACTGCAATTTAAGTCCTTCCTTTGATAATACTTCAAAACATACACAGCTTTGCTTACTGAATTATTTTTGCAAATAATACAAGGAGGG
GAAACTAACTTGCTACTAGTGTTGTTAATGAAGTATAGGCCTTGGAACATTTAAGAAAACTGGTCTTCAGATAGTTAAGGGCTTGGGATA
ATTTAAGTGAAAAGTGAGATCAGTAATGAGCTGTGTTGTTAACAATATTATCTGGTAATAATACCATGCAATATAGCGTTGTATACCAAC
TTAGTGCATTTTATACTGTATTAAATATGGAGATACTTCTAATGCCTCTCTAAAATTAAATTTTACATAAAAGTTAGTTTTATTCACCTT
TAGGCTTTCCAAGTGAATTGTGACTAATTTTTTCAATCTTACATAGATCTTTCACCCATTAGCATTACTTACGTAGATAATTCTTTATGC
CTAGTTATTATACATATTAATTTTTAAGGTATACATTTAAATTACACAATTGTTCATTGTGGTTTGTATCCCAGAATGTGTTGTGTTTTT
TAAAAGATGCATAATAGCTGAATGTATGCATGACTTTGAAAGAAGTTAAAATGGTGATTTTTTTTCACCTCTTGTACATTTTAAAACCAG
GCCAAATCTATTTGCCAAGCAGTGTATCACTAATAAGAAAAGCAGTTTTTCCTTTTATTGCAGTTTTTGTTTATCTGCCATAGAATTTCC
TTATACTGTGGCTTGGTATTATTCAAGATTAGCTATTTCGCTGGTATTACATCTTTTTAAAAGCCTATTATAACATGGTTAGCCTATAAG
GCAGTGTTGGTCCCCTTCTAATATTGGCCTCATAAAGGGGTTCCACTGTACTTTCCGCATATTACTGTGTTGTTGTTTTCCTTTGTGGAT
ATATAAGCAAATTGAGCTTGGGTGATTTTTATGGAGACAATAATTAGACAATACTGTATAATTAGTTTTACTTAATAGATTATCATCTTG
TGAGAAGAGATGTTTAAACGTGGTAAATCACTTCATATTACAAAACAGTTTTACACTTAATATGTTAACATTGGGTGCAATAATTTAGTA
GCATTAGCTTTAGTTACAAATATAACTGGATCTTTCTGCTGACAACTTAGGTTGTATGAGTTATGCTTAAAAGCTTTAAATCTGATGTTT
CCTGTACCTGCCACACTATGTTAGAATGTGTCCTTCAAACATATCCTCCTGCAACTTCTCAAACTGTACTAAATTGATATTTCTTGAAGT
CTAACTCTGTGCTAACAGATCTCCATTTTAAATAGAATACGGTTTTAATTTTTGATAAGCTGCTGAATTTTAAAGAGAGTTTTTTGGGGC
CACCAAATATTTTGGATCATGCAGAGAATATATATTGTACTGTAGTAATTTTGTATTTACATTTGTATGATGTGACATAATAGATGTGAA
TGTTAATCACTGCTTGACTATGTTAATAAAGTTGTTTAACTATAGATGTTGCACTCTGATTTTTAATGAAAGGAAATGAGTTTTCTTTTT
CCCTCTTACCCCATTTTGGATCTAGATAAGCCTTATGTTTTTTGGGATTTTTTTCCTTGTTTTTAGTTTGAGGTTTTGTTTTGTTTTTTC
CTTAGCTTACACATTAGTACACTTTTGTTGTTGAACATCATTTATTTCTTAAAACAAGTGTTTTCTTATTTGTATAGTATAGTAAAAACC
TGTTTTTCCACATTTTAACTTAACTCCTTGATGTGTTTTAAACAGTTGATTATAGGTTCTGCTGTTTGAGGATAGGGGACATACTATTCT
GTAAAAGGAATTAAAGGCGAAATTGTGAATATAAAAAGTTGATGTAAGGAGAGATTGCATGAGTGTGTATGAATGTATGTCCTATTAAGG
CTTCCTCTTTATCCTTCAAACAGTTAAGATTTGTAATTTGGGGAATTAACATTTATAAGAGTAATTTTTTCTTCAGGTTGTAAGGCATTA
ATATAGTTGCATGTTACTAATTAAATGTATTAACACATTTCAGGGAGTATGTGTGCATAACTGTCATGGTTTTTTTTGTTTTTTGTCTTG
TTTTTGAGATGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACAGTCTTGTCTCACTGCAACCTCTGCCTCCCGGGTTCAAAC
GACTCTCCTGCCTCAGCTTCCCAAGTAGTTGGGATTAAGGCATGTGCCGTCACACCCGGCTAACTTTTATATTTTCAGTAAAGATGGGGG
TTCACCATGTTGGCCAGGCTAGTCTCGAACTCCTGGCCTCAGGTGATCCACCTGTCTCGGCCTCTCAAAGTGTTGGGATTACAGCTGTGA
GCCACCATGCCTGGCCTTGTCATACAGCCTTTTGAGATTTAGAACAGGAAAGAGCCTAAAATTAAATCAGTACAATTCCAAAACTTTTAA
GAGAGGTGAGGCTTGGGTTTCTTTTTCTTTGTTACCTGGCCAAGAAAATATTTGAGAAGAGAGAGTTCTCTTGTGTTAACAAGAAAATAA
AATTGAAACTTGGACATCATGTTCTAAAACACAGCCTCAAGAGTTTAATATTCCAGAATTTTAGGACTTAGGTTGTGGGGAAAAGATAAT
TAAAGTCATCCTAATTCTTGTTCAAGATTAGGAACCAAAAGTCTTTTCTAAGTCGTCAATATTTTAGTGATACTAAAGCCCTATCCATTT
TATGCAAATGATCTTTTTCTTCTCAGTTCAGGTGATGAAACCATCGTAATGATAAATGAGTAAGGCTGGCTTAACAATTCTTGGACTGGC
GGGCATTCTTGTAATGAGTTCATAATCAGTATGACTCCACAATTTCACGTGATTCTTTAAGAATGATTGGAAAAGTGGCAGCAGGAACTA
CAGAGCTAACTTGAATTTCCTTTGTGTTCTATACAGTTGAATATGGAATTACCAAAGCTCTGTCATTTTAAAAATTCTTTATTTCTGAGT
TGTTAATTTGATGTAAAAGTGTAAGAACCCCCGAAACATCTCCATTATTCAGATAGACACAAATAATGTACACATCACAATTAGTATATA
TTTTTTTTAATTGAGAGGACTCTGGCTCTGTCTCCCAGTCTTCAGTGGCACGATATCTGCTCCCTGCAACTTCCGCCTCCTAGGTTCAAG
CAATTCTCCCATCTCAGCCTCCCAAGTAGCTGGGATTACAGGCGCACGCCACCAGGCCTGGCTAATTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTAGGAGAGAGTTTGGCCGTGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCGAGTGAACACCTCGAGTGGTACGCCCACCTTT
GCCTCCCAAATTGCTGGGATTACAGTTGTGAGCCACCGCCCCTGGCGACAATTTGTAAATTTAACGCAATTTCTAAACCATTGGCAAGAA
CAATACAGAGAAGAGTTGTTATACTGAGACCCTTTAGGTTTTTGTACCAGTCAATTCTTACATGCATGTTATGGCAGTCTCACTCTGATG
ATTTAAATCTTAAGTATTCTTTTCAAGCTTTGTGTTACTTCTTGAAGAACTTGAAACAATTTTAAGAAAGACAAGTGAACAGTTAAATGA
ATTGTAATACAACTACCTAGTGATAACTGCTGTTAATATCCTGTGCACATATATAAATATATGGTGAATTTGTGTTTTTAGTTATATCCA
GAATTGTTTGTTAATATACATGGACATACCTACATATTATTCTATAAGCAATTTATGCAACTGTCTTACTGTTGTTGGACATTCAGAAGT

>61533_61533_1_OPA3-TNPO1_OPA3_chr19_46087881_ENST00000263275_TNPO1_chr5_72144212_ENST00000337273_length(amino acids)=918AA_BP=23
MPTVLRRPPAEASSSRPISASRRLNQTKMEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEDE
PTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGAL
QKICEDSAEILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALVML
LEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSE
QDIRPRFHRSRTVAQQHDEDGIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILVLG
AIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEAC
TELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFL
PYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLG
DLTKACFQHVKPCIADFMPILGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRLGYVC
PQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRF

--------------------------------------------------------------
>61533_61533_2_OPA3-TNPO1_OPA3_chr19_46087881_ENST00000263275_TNPO1_chr5_72144212_ENST00000454282_length(transcript)=8444nt_BP=197nt
GTTGAGGCGCCCCGCCCAGTCAGCAAGGTTGCGCGTGCCCTGTGAGACCGCCAAGATGGTGGTGGGCGCGTTCCCTATGGCGAAGCTGCT
ATACTTGGGCATCCGGCAGGTCAGCAAGCCGCTTGCCAACCGTATTAAGGAGGCCGCCCGCCGAAGCGAGTTCTTCAAGACCTATATCTG
CCTCCCGCCGGCTCAACCAAACCAAGATGGAGTATGAGTGGAAACCTGACGAGCAAGGGCTTCAGCAAATCCTGCAGCTGTTGAAGGAGT
CCCAGTCCCCAGACACCACCATCCAGAGAACCGTGCAACAAAAACTGGAACAACTTAATCAGTATCCAGACTTTAACAACTACTTGATTT
TTGTTCTTACAAAATTAAAATCTGAAGGTATTTTGATCACAACTATAGCCTCCAAGGGAGAATTGCAGAATTGGCCTGACCTCTTACCAA
AACTCTGTAGCCTGTTGGATTCTGAAGATTATAATACCTGTGAGGGAGCATTTGGTGCCCTTCAGAAGATTTGTGAAGATTCTGCTGAGA
TTTTAGACAGTGATGTTTTAGATCGTCCTCTCAACATCATGATTCCCAAATTTTTACAGTTCTTCAAGCATAGTAGTCCAAAAATAAGGT
CTCACGCTGTTGCATGTGTCAATCAGTTTATCATCAGTAGGACTCAAGCTCTAATGTTGCACATTGATTCTTTTATTGAGAATCTCTTTG
CATTAGCTGGTGATGAAGAACCAGAGGTACGGAAAAATGTGTGCCGAGCACTTGTGATGTTGCTCGAAGTTCGAATGGATCGCCTGCTTC
CTCACATGCATAATATAGTTGAGTACATGCTACAGAGGACTCAAGATCAAGATGAAAATGTGGCTTTAGAAGCCTGTGAATTTTGGCTAA
CTTTAGCTGAACAGCCAATATGCAAAGATGTACTCGTAAGGCATCTTCCTAAGTTGATTCCTGTGTTAGTGAATGGCATGAAGTACTCAG
ACATAGATATTATCCTACTTAAGGGTGATGTTGAAGAAGACGAAACGATTCCTGATAGTGAACAGGATATACGGCCACGTTTTCACCGAT
CGAGGACGGTGGCTCAGCAGCATGATGAAGATGGAATTGAAGAGGAAGATGATGATGATGATGAAATTGATGATGATGATACAATTTCTG
ACTGGAATCTAAGAAAATGTTCTGCTGCTGCCCTGGATGTTCTTGCAAATGTGTATCGTGATGAACTGCTGCCACATATTTTGCCCCTTT
TGAAAGAATTACTTTTTCATCATGAATGGGTTGTTAAAGAATCAGGCATTTTGGTTTTAGGAGCAATTGCTGAAGGTTGCATGCAGGGCA
TGATTCCATACTTGCCTGAGCTTATTCCTCACCTTATTCAGTGCCTCTCTGATAAAAAGGCTCTTGTGCGTTCCATAACATGCTGGACTC
TTAGCCGCTATGCACACTGGGTGGTCAGCCAGCCGCCAGACACGTACCTGAAGCCATTAATGACAGAATTGCTAAAGCGCATCCTGGACA
GCAACAAGAGAGTACAAGAAGCTGCCTGCAGTGCCTTTGCTACCCTAGAAGAGGAGGCTTGTACAGAACTTGTTCCTTACCTTGCTTATA
TACTTGATACCCTGGTCTTTGCATTTAGTAAATACCAGCATAAGAACCTGCTCATTCTTTACGATGCCATAGGAACATTAGCAGATTCAG
TAGGACATCATTTAAACAAACCAGAATATATTCAGATGCTAATGCCTCCACTGATCCAGAAATGGAACATGTTAAAGGATGAAGATAAAG
ATCTCTTCCCTTTACTTGAGTGCCTATCTTCAGTTGCCACAGCACTGCAGTCTGGATTCCTTCCGTACTGTGAACCTGTGTATCAGCGTT
GTGTAAACCTAGTACAGAAGACTCTTGCACAAGCCATGCTAAACAATGCTCAACCAGATCAATATGAAGCTCCAGATAAAGATTTTATGA
TAGTGGCTCTTGATTTACTGAGTGGCCTGGCTGAAGGACTTGGAGGCAACATTGAACAGCTGGTAGCCCGAAGTAACATCCTGACACTAA
TGTATCAGTGCATGCAGGATAAAATGCCAGAAGTTCGACAGAGTTCTTTTGCCCTGTTAGGTGACCTCACAAAAGCTTGCTTTCAGCATG
TTAAGCCTTGTATAGCTGATTTCATGCCAATATTGGGAACCAACCTAAATCCAGAATTCATTTCAGTCTGCAACAATGCCACATGGGCAA
TTGGAGAAATCTCCATTCAAATGGGTATAGAGATGCAGCCTTATATTCCTATGGTGTTGCACCAGCTTGTAGAAATCATTAACAGACCCA
ACACACCAAAGACGTTGTTAGAGAATACAGCAATAACAATTGGTCGTCTTGGTTACGTTTGTCCTCAAGAGGTGGCCCCCATGCTACAGC
AGTTTATAAGACCCTGGTGCACCTCTCTGAGAAACATAAGAGACAATGAGGAAAAGGATTCAGCATTCCGTGGAATTTGTACCATGATCA
GTGTGAATCCCAGTGGCGTAATCCAAGATTTTATATTTTTTTGTGATGCCGTTGCATCATGGATTAACCCAAAAGATGATCTCAGAGACA
TGTTCTGTAAGATCCTTCATGGATTTAAAAATCAAGTTGGCGATGAAAATTGGAGGCGTTTCTCTGACCAGTTTCCTCTTCCCTTAAAAG
AGCGTCTTGCAGCTTTTTATGGTGTTTAATCTAATACACTTAAGCTGCAGTCCCAAAATTAGGGGTCCTTCAGTCTTGGAGACTATAAGG
GAGCCTCTGCACCCAGGGAAAATGTTACCCTTTACAGGGGGGAAGGGTAAACCAGTAGGGAATACAGTACAATCCCAACCCTACTGGGAG
GGGCGGGAGGGAGGTGTTGCCGTCACTGTATTAAGTCGATGTTGGGAAACGTTTTAACATCTGGAGCCTTTGTGGGTGGAAATATGTCTC
CAGTTACAACTCCGCAGTGGATGTGAAGAAGCAAAAAAAAAAAAATCTATTCAGTCTACTCACAAAACAGTACATTGTGGAATATTATGG
GGAATTGTACCAAAACAAGAACCATATAAATGATGCCTAGGGACAAGAAAGAGGAACAATTCTATAGCGCACAATAAAGGAAACCTAAGA
ATGGGAGTTACAAATAGTAAAGAAGCTTTTTTTTTTTTTTTAATTTAAAGTTTTTTTATGTAAGTTTTCCCACATGATGGGGCCTTGTTT
TGCATGTTGATGAAGAACTACACAAAGAAAACTAATATAGTTAAAAGTCAGCTTGCCTTCCCGTAGTAGAAGCAGGTTCTTGGAAGTTAC
AATTTAAGGTACCCCAAAAAAGTTGGAAATAAAACAAAACAAACATAAACAATGAAGCACCCTGTGAAATGCCAAATGAGTCACTCCTTT
TACCTTTTTTGGGGTGGGCAGGGAGGGAGGAATAAATGGGGTTGGGCATATCAAACTAAAGATGACATCTTAATTTTGCATTGAACATTA
ATGTAGCGGATATAATTTGATGATTATACTTCATTAGATTTAATTTCTAGGCCAAGATGTTACTTTTTAAAGTGCAGTTTAAGGTTCAGG
CATGCATTCTGGCTCATAGTGGTTGAAAGTAATTTAAATTAGTGGGAAAGTAGCATGCTTGCATCACATAGAGTGAGATTGGTATTCATT
TACCTATGTTGCGCCAGTTTGTGTTGCAGTTTACCAATTCAATATAGCCCTGCATTTAAAGTTCCTTTTTAAGATTTGTGGATTTTATTT
TTATTAAGAACATAGATATATAAAGTACTGTAGTTTACAGGTAGGCCTTGAAATATCTTTTTTAGGATCTGTTAGGAATAAGATTGATAT
TGTATTGTGTGTAACCTGCACAATGTGGAAAGCTGATATACCTGTGCAAAATCTTTGCCTCTGTGCTGTCAGTGTGATGTGCTTTCTGCA
TGGTTATATACTACTAGTGATTTTATCAAAACTTCTAAAATTTAAATTACGTGGTAAAAGATCTGTAAAAGGCTGCATAAATGTTAGTTG
GCACATAAAGACAATTGTAGAAGTTGAAAAATGATTGCTATATTTCAATGTTTATTCCCACTCAACATACTGCCTTCTAAGCTTCCCTTT
TTTTGTTCAAAGCATGATCTTAAAGATATGTTTAAGTTAATGGATGTAATGCAGGGTTCCTACACTGTATTTTGGCGCATGTTGGTGGCC
CTCTGTGCCCTAGATATATGCACACAGGGTGCAAGTTAAAAGCTACAGAGTGAAAGTTGGTTTGGATCCTCTTCATTTCATTTGTTTAGC
TTTTCTGTTATTTTTCTCTACTTACATGTATTCCTGTGAATAAATCCTTGTTAAGTTAACCCTTTACTTTTCCTTCCATGTGTATTTTCT
TATATACTGTGAATGTGAAAACCTAACTGGTACACTTGATCTTGTGTTCATATGAAAGTGCAAGTCTTTATTAATTTGGATTGCCTGAAC
AGTGTATCCCATGATGATGAAGGAAAATGGAGAGATTTTTCTTTTTAACTCTGCTGGTCAGAGATGAAGCCACGCCTTTCCATTTTTCAA
TGCTGCATATTTAATCTGCAACAAAAATGTTAAGCCATAACAGCCTTTTTATATTTTAGTTTGTCACCTTTGCATTGCAGAATAAATACT
GAATAACCATTTTTATAAGCAGTTGCTCCTCTTTGCATGGTTCTATTCTCTAAAAGTGTTGAATGATACAGCCATTGCACTGAAGTTTGA
GCTGTGTGCGTGTGAATTTATACTGTTTCAAAAATTTCAAATGCATGGTAGCATGTAGAAAGGTTTTTGTTACTATGTGTGTGTGTGTGT
TTTGTTTTGTTTTGTTCTGTTTTTTAACGTTCTTTCACCTTTCCTCTACTTTGGCTTTGCAAATTTCAGTCTGTAGAGCCTGAAATTAAA
TTATTTTATAGTGCCTGATATTTTTAATATTATAAGTTGGATTCAAAGGGTATACAGCATTTTGTTTTCTAGTACCATTGCTTCACTGGG
AGCTCAAAATTTGCCTCCCTGTTAGTCTTTAATAACTGAGTAGAGTAGCTTTTTTATTCTTAGATTATAGTGATATTCTGTAGTGCTTCA
AATACTTAGAATTCTAATATGAGAGATAGTTTAATATTCTGGAATAGAGAGTATTTTAAATTGAAATGACCAAATTCGATTTAAAACAAA
CACATAACAATCTTCAGTAAAGTTATTTGAACCTGTGGTTGACAATTCTGTATTGACTAAAGGCAATATTGTCACCTGTCTCATTAAAAA
TTAGTTTCCAGTTAGGCAGATGAATAACACTATTAAAAATGCACCCAGTTTTGTAGTCACTTGACTTTTTTTTTTTATTTAAATGAAATT
TAATTTGAAAATAGAAAATAAAATTAGGTAAATATGACTGGCAACCTGAATTTGAGTTGGGATTCTTTGTGTATTTTTCCCCCTTGAGGT
TATTGTTTCTTCCTAATTTATATTTCAGATACATAGTGTAGAACAGGAATTTGCAGAAGCCATTTAAGTTATCTTTTGAGGTAAGCTCTG
ATTTAGCATTTATTCTGATAAAATCTAATACATCATGGGATATATATAAAGCAACTTAATTCTTGTGGTGTAGTCTTAATAGTTTTGAAT
GTTGACTGAATGTCTATAAAATTGTGAGTTTGTCTTTGTTACATTCCAGTGTTTCTGCCTCTTGGCATGCTTAAAGCACGGCTTACTTCA
TCTGCTCCTTACACACTAAAATGCTGTTAGTGTGCTCAACTACAGAAATAGCCGCTGCTAAGTGATGTAGATTTTCTACTTGAATATTTT
TATGTTGTAGGAACCTCAGGAGGTCAGTGTTTACTGTTTTATATATGCCTTCTTTTTCCTGTTTGAGCTTCTCTCTTTGAAGGATTCTAA
CAGAACAAAGCTGCTGATCAACCTAAGTTGGAAACAGAAAGTGTAATTAATATAACTTAAATGCATGTTTGGCAGTTCCATGTTACAGTC
CATTAGCGAGTGAACTTAGTGCCACAGGTATTCATTTATTCAGGAAAGAATTTTGCTTTTTGTATTGTCTAATCTCTTCAATGACTTCAT
ACTGTGTAAAAAAAAATCACTTTTTAATATTTTTTGGTTGGTTATTTCCCAAATAATCAACATGTAAATAATCTTTTAAGAGCCAGTTCT
GATGCTTTACATTATTGCTACTTGATTTTGTTATGCAAGTTAGATTTCAGAAGAATAGATTTTAAAACACTTAACCAAGCCATTACATCT
TAAAAACAAAACAAGTAGCATACATTTTGTAATTAACATTGATAAACACTGTGATTTTTTTGGTTAAGACTTTTTCATTGATCTGAATTG
CTTAAATTGCATATATTGTAAAATAGGATCAGATGTATATTTTAAACTAATTTCAATGGATTTTCCTCTTGAAATGCTTTGTCTACTCAG
TTATAAAATATTCAGATACAAGTTTTATCTCAGGTGAATACTCTTGTATTGTTTTTGCTTTGGTGACATGCTTATAAAGGGTCATCCTAG
TTACATTCTTTGTTTTTTAAGTGTATTTCATTGAGAATCTTTCCATTTAGTCTGATTTTTTTCCTAATATTCTAGCAGGCTGGGGTGGTA
TAAAGCCCTCCTGACAAGCCTTTTGCCTACAGGTTTACCTGAAAATGAGCTACATATGGTCGTCATTTTCTTCAAACTCTCAAAATAGGA
AAGTGGAAATTTTTCTCCCCTATATAAAATTATTCTGCCTAGCAGAAATGCCAGAAATAAATTAATTGCATCTTAGTCTAAATTTAAGTC
CTTTGCCATGAGGAAAAAGTGGTTTTTTGCTTCATATGGTAAATCTATATTATTCATATTGAATGTATTAACAGATAATGGTGCAAAAGC
ATTCTTCCCAGGGGAAGAGTGTATCATGCATAACTGCAATTTAAGTCCTTCCTTTGATAATACTTCAAAACATACACAGCTTTGCTTACT
GAATTATTTTTGCAAATAATACAAGGAGGGGAAACTAACTTGCTACTAGTGTTGTTAATGAAGTATAGGCCTTGGAACATTTAAGAAAAC
TGGTCTTCAGATAGTTAAGGGCTTGGGATAATTTAAGTGAAAAGTGAGATCAGTAATGAGCTGTGTTGTTAACAATATTATCTGGTAATA
ATACCATGCAATATAGCGTTGTATACCAACTTAGTGCATTTTATACTGTATTAAATATGGAGATACTTCTAATGCCTCTCTAAAATTAAA
TTTTACATAAAAGTTAGTTTTATTCACCTTTAGGCTTTCCAAGTGAATTGTGACTAATTTTTTCAATCTTACATAGATCTTTCACCCATT
AGCATTACTTACGTAGATAATTCTTTATGCCTAGTTATTATACATATTAATTTTTAAGGTATACATTTAAATTACACAATTGTTCATTGT
GGTTTGTATCCCAGAATGTGTTGTGTTTTTTAAAAGATGCATAATAGCTGAATGTATGCATGACTTTGAAAGAAGTTAAAATGGTGATTT
TTTTTCACCTCTTGTACATTTTAAAACCAGGCCAAATCTATTTGCCAAGCAGTGTATCACTAATAAGAAAAGCAGTTTTTCCTTTTATTG
CAGTTTTTGTTTATCTGCCATAGAATTTCCTTATACTGTGGCTTGGTATTATTCAAGATTAGCTATTTCGCTGGTATTACATCTTTTTAA
AAGCCTATTATAACATGGTTAGCCTATAAGGCAGTGTTGGTCCCCTTCTAATATTGGCCTCATAAAGGGGTTCCACTGTACTTTCCGCAT
ATTACTGTGTTGTTGTTTTCCTTTGTGGATATATAAGCAAATTGAGCTTGGGTGATTTTTATGGAGACAATAATTAGACAATACTGTATA
ATTAGTTTTACTTAATAGATTATCATCTTGTGAGAAGAGATGTTTAAACGTGGTAAATCACTTCATATTACAAAACAGTTTTACACTTAA
TATGTTAACATTGGGTGCAATAATTTAGTAGCATTAGCTTTAGTTACAAATATAACTGGATCTTTCTGCTGACAACTTAGGTTGTATGAG
TTATGCTTAAAAGCTTTAAATCTGATGTTTCCTGTACCTGCCACACTATGTTAGAATGTGTCCTTCAAACATATCCTCCTGCAACTTCTC
AAACTGTACTAAATTGATATTTCTTGAAGTCTAACTCTGTGCTAACAGATCTCCATTTTAAATAGAATACGGTTTTAATTTTTGATAAGC
TGCTGAATTTTAAAGAGAGTTTTTTGGGGCCACCAAATATTTTGGATCATGCAGAGAATATATATTGTACTGTAGTAATTTTGTATTTAC

>61533_61533_2_OPA3-TNPO1_OPA3_chr19_46087881_ENST00000263275_TNPO1_chr5_72144212_ENST00000454282_length(amino acids)=868AA_BP=23
MPTVLRRPPAEASSSRPISASRRLNQTKMEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEGI
LITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVNQFI
ISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDV
LVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDEDGIEEEDDDDDEIDDDDTISDWNLRKCSAAA
LDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQ
PPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYI
QMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLA
EGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFISVCNNATWAIGEISIQMGIE
MQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDF

--------------------------------------------------------------
>61533_61533_3_OPA3-TNPO1_OPA3_chr19_46087881_ENST00000323060_TNPO1_chr5_72144212_ENST00000337273_length(transcript)=10962nt_BP=220nt
GAGGGCGGGGGAGGAGTGAAGAGGTTGAGGCGCCCCGCCCAGTCAGCAAGGTTGCGCGTGCCCTGTGAGACCGCCAAGATGGTGGTGGGC
GCGTTCCCTATGGCGAAGCTGCTATACTTGGGCATCCGGCAGGTCAGCAAGCCGCTTGCCAACCGTATTAAGGAGGCCGCCCGCCGAAGC
GAGTTCTTCAAGACCTATATCTGCCTCCCGCCGGCTCAACCAAACCAAGATGGAGTATGAGTGGAAACCTGACGAGCAAGGGCTTCAGCA
AATCCTGCAGCTGTTGAAGGAGTCCCAGTCCCCAGACACCACCATCCAGAGAACCGTGCAACAAAAACTGGAACAACTTAATCAGTATCC
AGACTTTAACAACTACTTGATTTTTGTTCTTACAAAATTAAAATCTGAAGATGAACCCACAAGATCATTGAGTGGTCTTATCTTGAAGAA
TAATGTGAAAGCACACTTTCAGAACTTCCCAAATGGTGTAACAGACTTTATTAAAAGTGAATGTTTAAATAATATTGGTGACTCCTCTCC
TCTGATTAGAGCCACTGTTGGTATTTTGATCACAACTATAGCCTCCAAGGGAGAATTGCAGAATTGGCCTGACCTCTTACCAAAACTCTG
TAGCCTGTTGGATTCTGAAGATTATAATACCTGTGAGGGAGCATTTGGTGCCCTTCAGAAGATTTGTGAAGATTCTGCTGAGATTTTAGA
CAGTGATGTTTTAGATCGTCCTCTCAACATCATGATTCCCAAATTTTTACAGTTCTTCAAGCATAGTAGTCCAAAAATAAGGTCTCACGC
TGTTGCATGTGTCAATCAGTTTATCATCAGTAGGACTCAAGCTCTAATGTTGCACATTGATTCTTTTATTGAGAATCTCTTTGCATTAGC
TGGTGATGAAGAACCAGAGGTACGGAAAAATGTGTGCCGAGCACTTGTGATGTTGCTCGAAGTTCGAATGGATCGCCTGCTTCCTCACAT
GCATAATATAGTTGAGTACATGCTACAGAGGACTCAAGATCAAGATGAAAATGTGGCTTTAGAAGCCTGTGAATTTTGGCTAACTTTAGC
TGAACAGCCAATATGCAAAGATGTACTCGTAAGGCATCTTCCTAAGTTGATTCCTGTGTTAGTGAATGGCATGAAGTACTCAGACATAGA
TATTATCCTACTTAAGGGTGATGTTGAAGAAGACGAAACGATTCCTGATAGTGAACAGGATATACGGCCACGTTTTCACCGATCGAGGAC
GGTGGCTCAGCAGCATGATGAAGATGGAATTGAAGAGGAAGATGATGATGATGATGAAATTGATGATGATGATACAATTTCTGACTGGAA
TCTAAGAAAATGTTCTGCTGCTGCCCTGGATGTTCTTGCAAATGTGTATCGTGATGAACTGCTGCCACATATTTTGCCCCTTTTGAAAGA
ATTACTTTTTCATCATGAATGGGTTGTTAAAGAATCAGGCATTTTGGTTTTAGGAGCAATTGCTGAAGGTTGCATGCAGGGCATGATTCC
ATACTTGCCTGAGCTTATTCCTCACCTTATTCAGTGCCTCTCTGATAAAAAGGCTCTTGTGCGTTCCATAACATGCTGGACTCTTAGCCG
CTATGCACACTGGGTGGTCAGCCAGCCGCCAGACACGTACCTGAAGCCATTAATGACAGAATTGCTAAAGCGCATCCTGGACAGCAACAA
GAGAGTACAAGAAGCTGCCTGCAGTGCCTTTGCTACCCTAGAAGAGGAGGCTTGTACAGAACTTGTTCCTTACCTTGCTTATATACTTGA
TACCCTGGTCTTTGCATTTAGTAAATACCAGCATAAGAACCTGCTCATTCTTTACGATGCCATAGGAACATTAGCAGATTCAGTAGGACA
TCATTTAAACAAACCAGAATATATTCAGATGCTAATGCCTCCACTGATCCAGAAATGGAACATGTTAAAGGATGAAGATAAAGATCTCTT
CCCTTTACTTGAGTGCCTATCTTCAGTTGCCACAGCACTGCAGTCTGGATTCCTTCCGTACTGTGAACCTGTGTATCAGCGTTGTGTAAA
CCTAGTACAGAAGACTCTTGCACAAGCCATGCTAAACAATGCTCAACCAGATCAATATGAAGCTCCAGATAAAGATTTTATGATAGTGGC
TCTTGATTTACTGAGTGGCCTGGCTGAAGGACTTGGAGGCAACATTGAACAGCTGGTAGCCCGAAGTAACATCCTGACACTAATGTATCA
GTGCATGCAGGATAAAATGCCAGAAGTTCGACAGAGTTCTTTTGCCCTGTTAGGTGACCTCACAAAAGCTTGCTTTCAGCATGTTAAGCC
TTGTATAGCTGATTTCATGCCAATATTGGGAACCAACCTAAATCCAGAATTCATTTCAGTCTGCAACAATGCCACATGGGCAATTGGAGA
AATCTCCATTCAAATGGGTATAGAGATGCAGCCTTATATTCCTATGGTGTTGCACCAGCTTGTAGAAATCATTAACAGACCCAACACACC
AAAGACGTTGTTAGAGAATACAGCAATAACAATTGGTCGTCTTGGTTACGTTTGTCCTCAAGAGGTGGCCCCCATGCTACAGCAGTTTAT
AAGACCCTGGTGCACCTCTCTGAGAAACATAAGAGACAATGAGGAAAAGGATTCAGCATTCCGTGGAATTTGTACCATGATCAGTGTGAA
TCCCAGTGGCGTAATCCAAGATTTTATATTTTTTTGTGATGCCGTTGCATCATGGATTAACCCAAAAGATGATCTCAGAGACATGTTCTG
TAAGATCCTTCATGGATTTAAAAATCAAGTTGGCGATGAAAATTGGAGGCGTTTCTCTGACCAGTTTCCTCTTCCCTTAAAAGAGCGTCT
TGCAGCTTTTTATGGTGTTTAATCTAATACACTTAAGCTGCAGTCCCAAAATTAGGGGTCCTTCAGTCTTGGAGACTATAAGGGAGCCTC
TGCACCCAGGGAAAATGTTACCCTTTACAGGGGGGAAGGGTAAACCAGTAGGGAATACAGTACAATCCCAACCCTACTGGGAGGGGCGGG
AGGGAGGTGTTGCCGTCACTGTATTAAGTCGATGTTGGGAAACGTTTTAACATCTGGAGCCTTTGTGGGTGGAAATATGTCTCCAGTTAC
AACTCCGCAGTGGATGTGAAGAAGCAAAAAAAAAAAAATCTATTCAGTCTACTCACAAAACAGTACATTGTGGAATATTATGGGGAATTG
TACCAAAACAAGAACCATATAAATGATGCCTAGGGACAAGAAAGAGGAACAATTCTATAGCGCACAATAAAGGAAACCTAAGAATGGGAG
TTACAAATAGTAAAGAAGCTTTTTTTTTTTTTTTAATTTAAAGTTTTTTTATGTAAGTTTTCCCACATGATGGGGCCTTGTTTTGCATGT
TGATGAAGAACTACACAAAGAAAACTAATATAGTTAAAAGTCAGCTTGCCTTCCCGTAGTAGAAGCAGGTTCTTGGAAGTTACAATTTAA
GGTACCCCAAAAAAGTTGGAAATAAAACAAAACAAACATAAACAATGAAGCACCCTGTGAAATGCCAAATGAGTCACTCCTTTTACCTTT
TTTGGGGTGGGCAGGGAGGGAGGAATAAATGGGGTTGGGCATATCAAACTAAAGATGACATCTTAATTTTGCATTGAACATTAATGTAGC
GGATATAATTTGATGATTATACTTCATTAGATTTAATTTCTAGGCCAAGATGTTACTTTTTAAAGTGCAGTTTAAGGTTCAGGCATGCAT
TCTGGCTCATAGTGGTTGAAAGTAATTTAAATTAGTGGGAAAGTAGCATGCTTGCATCACATAGAGTGAGATTGGTATTCATTTACCTAT
GTTGCGCCAGTTTGTGTTGCAGTTTACCAATTCAATATAGCCCTGCATTTAAAGTTCCTTTTTAAGATTTGTGGATTTTATTTTTATTAA
GAACATAGATATATAAAGTACTGTAGTTTACAGGTAGGCCTTGAAATATCTTTTTTAGGATCTGTTAGGAATAAGATTGATATTGTATTG
TGTGTAACCTGCACAATGTGGAAAGCTGATATACCTGTGCAAAATCTTTGCCTCTGTGCTGTCAGTGTGATGTGCTTTCTGCATGGTTAT
ATACTACTAGTGATTTTATCAAAACTTCTAAAATTTAAATTACGTGGTAAAAGATCTGTAAAAGGCTGCATAAATGTTAGTTGGCACATA
AAGACAATTGTAGAAGTTGAAAAATGATTGCTATATTTCAATGTTTATTCCCACTCAACATACTGCCTTCTAAGCTTCCCTTTTTTTGTT
CAAAGCATGATCTTAAAGATATGTTTAAGTTAATGGATGTAATGCAGGGTTCCTACACTGTATTTTGGCGCATGTTGGTGGCCCTCTGTG
CCCTAGATATATGCACACAGGGTGCAAGTTAAAAGCTACAGAGTGAAAGTTGGTTTGGATCCTCTTCATTTCATTTGTTTAGCTTTTCTG
TTATTTTTCTCTACTTACATGTATTCCTGTGAATAAATCCTTGTTAAGTTAACCCTTTACTTTTCCTTCCATGTGTATTTTCTTATATAC
TGTGAATGTGAAAACCTAACTGGTACACTTGATCTTGTGTTCATATGAAAGTGCAAGTCTTTATTAATTTGGATTGCCTGAACAGTGTAT
CCCATGATGATGAAGGAAAATGGAGAGATTTTTCTTTTTAACTCTGCTGGTCAGAGATGAAGCCACGCCTTTCCATTTTTCAATGCTGCA
TATTTAATCTGCAACAAAAATGTTAAGCCATAACAGCCTTTTTATATTTTAGTTTGTCACCTTTGCATTGCAGAATAAATACTGAATAAC
CATTTTTATAAGCAGTTGCTCCTCTTTGCATGGTTCTATTCTCTAAAAGTGTTGAATGATACAGCCATTGCACTGAAGTTTGAGCTGTGT
GCGTGTGAATTTATACTGTTTCAAAAATTTCAAATGCATGGTAGCATGTAGAAAGGTTTTTGTTACTATGTGTGTGTGTGTGTTTTGTTT
TGTTTTGTTCTGTTTTTTAACGTTCTTTCACCTTTCCTCTACTTTGGCTTTGCAAATTTCAGTCTGTAGAGCCTGAAATTAAATTATTTT
ATAGTGCCTGATATTTTTAATATTATAAGTTGGATTCAAAGGGTATACAGCATTTTGTTTTCTAGTACCATTGCTTCACTGGGAGCTCAA
AATTTGCCTCCCTGTTAGTCTTTAATAACTGAGTAGAGTAGCTTTTTTATTCTTAGATTATAGTGATATTCTGTAGTGCTTCAAATACTT
AGAATTCTAATATGAGAGATAGTTTAATATTCTGGAATAGAGAGTATTTTAAATTGAAATGACCAAATTCGATTTAAAACAAACACATAA
CAATCTTCAGTAAAGTTATTTGAACCTGTGGTTGACAATTCTGTATTGACTAAAGGCAATATTGTCACCTGTCTCATTAAAAATTAGTTT
CCAGTTAGGCAGATGAATAACACTATTAAAAATGCACCCAGTTTTGTAGTCACTTGACTTTTTTTTTTTATTTAAATGAAATTTAATTTG
AAAATAGAAAATAAAATTAGGTAAATATGACTGGCAACCTGAATTTGAGTTGGGATTCTTTGTGTATTTTTCCCCCTTGAGGTTATTGTT
TCTTCCTAATTTATATTTCAGATACATAGTGTAGAACAGGAATTTGCAGAAGCCATTTAAGTTATCTTTTGAGGTAAGCTCTGATTTAGC
ATTTATTCTGATAAAATCTAATACATCATGGGATATATATAAAGCAACTTAATTCTTGTGGTGTAGTCTTAATAGTTTTGAATGTTGACT
GAATGTCTATAAAATTGTGAGTTTGTCTTTGTTACATTCCAGTGTTTCTGCCTCTTGGCATGCTTAAAGCACGGCTTACTTCATCTGCTC
CTTACACACTAAAATGCTGTTAGTGTGCTCAACTACAGAAATAGCCGCTGCTAAGTGATGTAGATTTTCTACTTGAATATTTTTATGTTG
TAGGAACCTCAGGAGGTCAGTGTTTACTGTTTTATATATGCCTTCTTTTTCCTGTTTGAGCTTCTCTCTTTGAAGGATTCTAACAGAACA
AAGCTGCTGATCAACCTAAGTTGGAAACAGAAAGTGTAATTAATATAACTTAAATGCATGTTTGGCAGTTCCATGTTACAGTCCATTAGC
GAGTGAACTTAGTGCCACAGGTATTCATTTATTCAGGAAAGAATTTTGCTTTTTGTATTGTCTAATCTCTTCAATGACTTCATACTGTGT
AAAAAAAAATCACTTTTTAATATTTTTTGGTTGGTTATTTCCCAAATAATCAACATGTAAATAATCTTTTAAGAGCCAGTTCTGATGCTT
TACATTATTGCTACTTGATTTTGTTATGCAAGTTAGATTTCAGAAGAATAGATTTTAAAACACTTAACCAAGCCATTACATCTTAAAAAC
AAAACAAGTAGCATACATTTTGTAATTAACATTGATAAACACTGTGATTTTTTTGGTTAAGACTTTTTCATTGATCTGAATTGCTTAAAT
TGCATATATTGTAAAATAGGATCAGATGTATATTTTAAACTAATTTCAATGGATTTTCCTCTTGAAATGCTTTGTCTACTCAGTTATAAA
ATATTCAGATACAAGTTTTATCTCAGGTGAATACTCTTGTATTGTTTTTGCTTTGGTGACATGCTTATAAAGGGTCATCCTAGTTACATT
CTTTGTTTTTTAAGTGTATTTCATTGAGAATCTTTCCATTTAGTCTGATTTTTTTCCTAATATTCTAGCAGGCTGGGGTGGTATAAAGCC
CTCCTGACAAGCCTTTTGCCTACAGGTTTACCTGAAAATGAGCTACATATGGTCGTCATTTTCTTCAAACTCTCAAAATAGGAAAGTGGA
AATTTTTCTCCCCTATATAAAATTATTCTGCCTAGCAGAAATGCCAGAAATAAATTAATTGCATCTTAGTCTAAATTTAAGTCCTTTGCC
ATGAGGAAAAAGTGGTTTTTTGCTTCATATGGTAAATCTATATTATTCATATTGAATGTATTAACAGATAATGGTGCAAAAGCATTCTTC
CCAGGGGAAGAGTGTATCATGCATAACTGCAATTTAAGTCCTTCCTTTGATAATACTTCAAAACATACACAGCTTTGCTTACTGAATTAT
TTTTGCAAATAATACAAGGAGGGGAAACTAACTTGCTACTAGTGTTGTTAATGAAGTATAGGCCTTGGAACATTTAAGAAAACTGGTCTT
CAGATAGTTAAGGGCTTGGGATAATTTAAGTGAAAAGTGAGATCAGTAATGAGCTGTGTTGTTAACAATATTATCTGGTAATAATACCAT
GCAATATAGCGTTGTATACCAACTTAGTGCATTTTATACTGTATTAAATATGGAGATACTTCTAATGCCTCTCTAAAATTAAATTTTACA
TAAAAGTTAGTTTTATTCACCTTTAGGCTTTCCAAGTGAATTGTGACTAATTTTTTCAATCTTACATAGATCTTTCACCCATTAGCATTA
CTTACGTAGATAATTCTTTATGCCTAGTTATTATACATATTAATTTTTAAGGTATACATTTAAATTACACAATTGTTCATTGTGGTTTGT
ATCCCAGAATGTGTTGTGTTTTTTAAAAGATGCATAATAGCTGAATGTATGCATGACTTTGAAAGAAGTTAAAATGGTGATTTTTTTTCA
CCTCTTGTACATTTTAAAACCAGGCCAAATCTATTTGCCAAGCAGTGTATCACTAATAAGAAAAGCAGTTTTTCCTTTTATTGCAGTTTT
TGTTTATCTGCCATAGAATTTCCTTATACTGTGGCTTGGTATTATTCAAGATTAGCTATTTCGCTGGTATTACATCTTTTTAAAAGCCTA
TTATAACATGGTTAGCCTATAAGGCAGTGTTGGTCCCCTTCTAATATTGGCCTCATAAAGGGGTTCCACTGTACTTTCCGCATATTACTG
TGTTGTTGTTTTCCTTTGTGGATATATAAGCAAATTGAGCTTGGGTGATTTTTATGGAGACAATAATTAGACAATACTGTATAATTAGTT
TTACTTAATAGATTATCATCTTGTGAGAAGAGATGTTTAAACGTGGTAAATCACTTCATATTACAAAACAGTTTTACACTTAATATGTTA
ACATTGGGTGCAATAATTTAGTAGCATTAGCTTTAGTTACAAATATAACTGGATCTTTCTGCTGACAACTTAGGTTGTATGAGTTATGCT
TAAAAGCTTTAAATCTGATGTTTCCTGTACCTGCCACACTATGTTAGAATGTGTCCTTCAAACATATCCTCCTGCAACTTCTCAAACTGT
ACTAAATTGATATTTCTTGAAGTCTAACTCTGTGCTAACAGATCTCCATTTTAAATAGAATACGGTTTTAATTTTTGATAAGCTGCTGAA
TTTTAAAGAGAGTTTTTTGGGGCCACCAAATATTTTGGATCATGCAGAGAATATATATTGTACTGTAGTAATTTTGTATTTACATTTGTA
TGATGTGACATAATAGATGTGAATGTTAATCACTGCTTGACTATGTTAATAAAGTTGTTTAACTATAGATGTTGCACTCTGATTTTTAAT
GAAAGGAAATGAGTTTTCTTTTTCCCTCTTACCCCATTTTGGATCTAGATAAGCCTTATGTTTTTTGGGATTTTTTTCCTTGTTTTTAGT
TTGAGGTTTTGTTTTGTTTTTTCCTTAGCTTACACATTAGTACACTTTTGTTGTTGAACATCATTTATTTCTTAAAACAAGTGTTTTCTT
ATTTGTATAGTATAGTAAAAACCTGTTTTTCCACATTTTAACTTAACTCCTTGATGTGTTTTAAACAGTTGATTATAGGTTCTGCTGTTT
GAGGATAGGGGACATACTATTCTGTAAAAGGAATTAAAGGCGAAATTGTGAATATAAAAAGTTGATGTAAGGAGAGATTGCATGAGTGTG
TATGAATGTATGTCCTATTAAGGCTTCCTCTTTATCCTTCAAACAGTTAAGATTTGTAATTTGGGGAATTAACATTTATAAGAGTAATTT
TTTCTTCAGGTTGTAAGGCATTAATATAGTTGCATGTTACTAATTAAATGTATTAACACATTTCAGGGAGTATGTGTGCATAACTGTCAT
GGTTTTTTTTGTTTTTTGTCTTGTTTTTGAGATGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACAGTCTTGTCTCACTGCA
ACCTCTGCCTCCCGGGTTCAAACGACTCTCCTGCCTCAGCTTCCCAAGTAGTTGGGATTAAGGCATGTGCCGTCACACCCGGCTAACTTT
TATATTTTCAGTAAAGATGGGGGTTCACCATGTTGGCCAGGCTAGTCTCGAACTCCTGGCCTCAGGTGATCCACCTGTCTCGGCCTCTCA
AAGTGTTGGGATTACAGCTGTGAGCCACCATGCCTGGCCTTGTCATACAGCCTTTTGAGATTTAGAACAGGAAAGAGCCTAAAATTAAAT
CAGTACAATTCCAAAACTTTTAAGAGAGGTGAGGCTTGGGTTTCTTTTTCTTTGTTACCTGGCCAAGAAAATATTTGAGAAGAGAGAGTT
CTCTTGTGTTAACAAGAAAATAAAATTGAAACTTGGACATCATGTTCTAAAACACAGCCTCAAGAGTTTAATATTCCAGAATTTTAGGAC
TTAGGTTGTGGGGAAAAGATAATTAAAGTCATCCTAATTCTTGTTCAAGATTAGGAACCAAAAGTCTTTTCTAAGTCGTCAATATTTTAG
TGATACTAAAGCCCTATCCATTTTATGCAAATGATCTTTTTCTTCTCAGTTCAGGTGATGAAACCATCGTAATGATAAATGAGTAAGGCT
GGCTTAACAATTCTTGGACTGGCGGGCATTCTTGTAATGAGTTCATAATCAGTATGACTCCACAATTTCACGTGATTCTTTAAGAATGAT
TGGAAAAGTGGCAGCAGGAACTACAGAGCTAACTTGAATTTCCTTTGTGTTCTATACAGTTGAATATGGAATTACCAAAGCTCTGTCATT
TTAAAAATTCTTTATTTCTGAGTTGTTAATTTGATGTAAAAGTGTAAGAACCCCCGAAACATCTCCATTATTCAGATAGACACAAATAAT
GTACACATCACAATTAGTATATATTTTTTTTAATTGAGAGGACTCTGGCTCTGTCTCCCAGTCTTCAGTGGCACGATATCTGCTCCCTGC
AACTTCCGCCTCCTAGGTTCAAGCAATTCTCCCATCTCAGCCTCCCAAGTAGCTGGGATTACAGGCGCACGCCACCAGGCCTGGCTAATT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTAGGAGAGAGTTTGGCCGTGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCGAGTGAACA
CCTCGAGTGGTACGCCCACCTTTGCCTCCCAAATTGCTGGGATTACAGTTGTGAGCCACCGCCCCTGGCGACAATTTGTAAATTTAACGC
AATTTCTAAACCATTGGCAAGAACAATACAGAGAAGAGTTGTTATACTGAGACCCTTTAGGTTTTTGTACCAGTCAATTCTTACATGCAT
GTTATGGCAGTCTCACTCTGATGATTTAAATCTTAAGTATTCTTTTCAAGCTTTGTGTTACTTCTTGAAGAACTTGAAACAATTTTAAGA
AAGACAAGTGAACAGTTAAATGAATTGTAATACAACTACCTAGTGATAACTGCTGTTAATATCCTGTGCACATATATAAATATATGGTGA
ATTTGTGTTTTTAGTTATATCCAGAATTGTTTGTTAATATACATGGACATACCTACATATTATTCTATAAGCAATTTATGCAACTGTCTT

>61533_61533_3_OPA3-TNPO1_OPA3_chr19_46087881_ENST00000323060_TNPO1_chr5_72144212_ENST00000337273_length(amino acids)=918AA_BP=23
MPTVLRRPPAEASSSRPISASRRLNQTKMEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEDE
PTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGAL
QKICEDSAEILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALVML
LEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSE
QDIRPRFHRSRTVAQQHDEDGIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILVLG
AIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEAC
TELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFL
PYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLG
DLTKACFQHVKPCIADFMPILGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRLGYVC
PQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRF

--------------------------------------------------------------
>61533_61533_4_OPA3-TNPO1_OPA3_chr19_46087881_ENST00000323060_TNPO1_chr5_72144212_ENST00000454282_length(transcript)=8467nt_BP=220nt
GAGGGCGGGGGAGGAGTGAAGAGGTTGAGGCGCCCCGCCCAGTCAGCAAGGTTGCGCGTGCCCTGTGAGACCGCCAAGATGGTGGTGGGC
GCGTTCCCTATGGCGAAGCTGCTATACTTGGGCATCCGGCAGGTCAGCAAGCCGCTTGCCAACCGTATTAAGGAGGCCGCCCGCCGAAGC
GAGTTCTTCAAGACCTATATCTGCCTCCCGCCGGCTCAACCAAACCAAGATGGAGTATGAGTGGAAACCTGACGAGCAAGGGCTTCAGCA
AATCCTGCAGCTGTTGAAGGAGTCCCAGTCCCCAGACACCACCATCCAGAGAACCGTGCAACAAAAACTGGAACAACTTAATCAGTATCC
AGACTTTAACAACTACTTGATTTTTGTTCTTACAAAATTAAAATCTGAAGGTATTTTGATCACAACTATAGCCTCCAAGGGAGAATTGCA
GAATTGGCCTGACCTCTTACCAAAACTCTGTAGCCTGTTGGATTCTGAAGATTATAATACCTGTGAGGGAGCATTTGGTGCCCTTCAGAA
GATTTGTGAAGATTCTGCTGAGATTTTAGACAGTGATGTTTTAGATCGTCCTCTCAACATCATGATTCCCAAATTTTTACAGTTCTTCAA
GCATAGTAGTCCAAAAATAAGGTCTCACGCTGTTGCATGTGTCAATCAGTTTATCATCAGTAGGACTCAAGCTCTAATGTTGCACATTGA
TTCTTTTATTGAGAATCTCTTTGCATTAGCTGGTGATGAAGAACCAGAGGTACGGAAAAATGTGTGCCGAGCACTTGTGATGTTGCTCGA
AGTTCGAATGGATCGCCTGCTTCCTCACATGCATAATATAGTTGAGTACATGCTACAGAGGACTCAAGATCAAGATGAAAATGTGGCTTT
AGAAGCCTGTGAATTTTGGCTAACTTTAGCTGAACAGCCAATATGCAAAGATGTACTCGTAAGGCATCTTCCTAAGTTGATTCCTGTGTT
AGTGAATGGCATGAAGTACTCAGACATAGATATTATCCTACTTAAGGGTGATGTTGAAGAAGACGAAACGATTCCTGATAGTGAACAGGA
TATACGGCCACGTTTTCACCGATCGAGGACGGTGGCTCAGCAGCATGATGAAGATGGAATTGAAGAGGAAGATGATGATGATGATGAAAT
TGATGATGATGATACAATTTCTGACTGGAATCTAAGAAAATGTTCTGCTGCTGCCCTGGATGTTCTTGCAAATGTGTATCGTGATGAACT
GCTGCCACATATTTTGCCCCTTTTGAAAGAATTACTTTTTCATCATGAATGGGTTGTTAAAGAATCAGGCATTTTGGTTTTAGGAGCAAT
TGCTGAAGGTTGCATGCAGGGCATGATTCCATACTTGCCTGAGCTTATTCCTCACCTTATTCAGTGCCTCTCTGATAAAAAGGCTCTTGT
GCGTTCCATAACATGCTGGACTCTTAGCCGCTATGCACACTGGGTGGTCAGCCAGCCGCCAGACACGTACCTGAAGCCATTAATGACAGA
ATTGCTAAAGCGCATCCTGGACAGCAACAAGAGAGTACAAGAAGCTGCCTGCAGTGCCTTTGCTACCCTAGAAGAGGAGGCTTGTACAGA
ACTTGTTCCTTACCTTGCTTATATACTTGATACCCTGGTCTTTGCATTTAGTAAATACCAGCATAAGAACCTGCTCATTCTTTACGATGC
CATAGGAACATTAGCAGATTCAGTAGGACATCATTTAAACAAACCAGAATATATTCAGATGCTAATGCCTCCACTGATCCAGAAATGGAA
CATGTTAAAGGATGAAGATAAAGATCTCTTCCCTTTACTTGAGTGCCTATCTTCAGTTGCCACAGCACTGCAGTCTGGATTCCTTCCGTA
CTGTGAACCTGTGTATCAGCGTTGTGTAAACCTAGTACAGAAGACTCTTGCACAAGCCATGCTAAACAATGCTCAACCAGATCAATATGA
AGCTCCAGATAAAGATTTTATGATAGTGGCTCTTGATTTACTGAGTGGCCTGGCTGAAGGACTTGGAGGCAACATTGAACAGCTGGTAGC
CCGAAGTAACATCCTGACACTAATGTATCAGTGCATGCAGGATAAAATGCCAGAAGTTCGACAGAGTTCTTTTGCCCTGTTAGGTGACCT
CACAAAAGCTTGCTTTCAGCATGTTAAGCCTTGTATAGCTGATTTCATGCCAATATTGGGAACCAACCTAAATCCAGAATTCATTTCAGT
CTGCAACAATGCCACATGGGCAATTGGAGAAATCTCCATTCAAATGGGTATAGAGATGCAGCCTTATATTCCTATGGTGTTGCACCAGCT
TGTAGAAATCATTAACAGACCCAACACACCAAAGACGTTGTTAGAGAATACAGCAATAACAATTGGTCGTCTTGGTTACGTTTGTCCTCA
AGAGGTGGCCCCCATGCTACAGCAGTTTATAAGACCCTGGTGCACCTCTCTGAGAAACATAAGAGACAATGAGGAAAAGGATTCAGCATT
CCGTGGAATTTGTACCATGATCAGTGTGAATCCCAGTGGCGTAATCCAAGATTTTATATTTTTTTGTGATGCCGTTGCATCATGGATTAA
CCCAAAAGATGATCTCAGAGACATGTTCTGTAAGATCCTTCATGGATTTAAAAATCAAGTTGGCGATGAAAATTGGAGGCGTTTCTCTGA
CCAGTTTCCTCTTCCCTTAAAAGAGCGTCTTGCAGCTTTTTATGGTGTTTAATCTAATACACTTAAGCTGCAGTCCCAAAATTAGGGGTC
CTTCAGTCTTGGAGACTATAAGGGAGCCTCTGCACCCAGGGAAAATGTTACCCTTTACAGGGGGGAAGGGTAAACCAGTAGGGAATACAG
TACAATCCCAACCCTACTGGGAGGGGCGGGAGGGAGGTGTTGCCGTCACTGTATTAAGTCGATGTTGGGAAACGTTTTAACATCTGGAGC
CTTTGTGGGTGGAAATATGTCTCCAGTTACAACTCCGCAGTGGATGTGAAGAAGCAAAAAAAAAAAAATCTATTCAGTCTACTCACAAAA
CAGTACATTGTGGAATATTATGGGGAATTGTACCAAAACAAGAACCATATAAATGATGCCTAGGGACAAGAAAGAGGAACAATTCTATAG
CGCACAATAAAGGAAACCTAAGAATGGGAGTTACAAATAGTAAAGAAGCTTTTTTTTTTTTTTTAATTTAAAGTTTTTTTATGTAAGTTT
TCCCACATGATGGGGCCTTGTTTTGCATGTTGATGAAGAACTACACAAAGAAAACTAATATAGTTAAAAGTCAGCTTGCCTTCCCGTAGT
AGAAGCAGGTTCTTGGAAGTTACAATTTAAGGTACCCCAAAAAAGTTGGAAATAAAACAAAACAAACATAAACAATGAAGCACCCTGTGA
AATGCCAAATGAGTCACTCCTTTTACCTTTTTTGGGGTGGGCAGGGAGGGAGGAATAAATGGGGTTGGGCATATCAAACTAAAGATGACA
TCTTAATTTTGCATTGAACATTAATGTAGCGGATATAATTTGATGATTATACTTCATTAGATTTAATTTCTAGGCCAAGATGTTACTTTT
TAAAGTGCAGTTTAAGGTTCAGGCATGCATTCTGGCTCATAGTGGTTGAAAGTAATTTAAATTAGTGGGAAAGTAGCATGCTTGCATCAC
ATAGAGTGAGATTGGTATTCATTTACCTATGTTGCGCCAGTTTGTGTTGCAGTTTACCAATTCAATATAGCCCTGCATTTAAAGTTCCTT
TTTAAGATTTGTGGATTTTATTTTTATTAAGAACATAGATATATAAAGTACTGTAGTTTACAGGTAGGCCTTGAAATATCTTTTTTAGGA
TCTGTTAGGAATAAGATTGATATTGTATTGTGTGTAACCTGCACAATGTGGAAAGCTGATATACCTGTGCAAAATCTTTGCCTCTGTGCT
GTCAGTGTGATGTGCTTTCTGCATGGTTATATACTACTAGTGATTTTATCAAAACTTCTAAAATTTAAATTACGTGGTAAAAGATCTGTA
AAAGGCTGCATAAATGTTAGTTGGCACATAAAGACAATTGTAGAAGTTGAAAAATGATTGCTATATTTCAATGTTTATTCCCACTCAACA
TACTGCCTTCTAAGCTTCCCTTTTTTTGTTCAAAGCATGATCTTAAAGATATGTTTAAGTTAATGGATGTAATGCAGGGTTCCTACACTG
TATTTTGGCGCATGTTGGTGGCCCTCTGTGCCCTAGATATATGCACACAGGGTGCAAGTTAAAAGCTACAGAGTGAAAGTTGGTTTGGAT
CCTCTTCATTTCATTTGTTTAGCTTTTCTGTTATTTTTCTCTACTTACATGTATTCCTGTGAATAAATCCTTGTTAAGTTAACCCTTTAC
TTTTCCTTCCATGTGTATTTTCTTATATACTGTGAATGTGAAAACCTAACTGGTACACTTGATCTTGTGTTCATATGAAAGTGCAAGTCT
TTATTAATTTGGATTGCCTGAACAGTGTATCCCATGATGATGAAGGAAAATGGAGAGATTTTTCTTTTTAACTCTGCTGGTCAGAGATGA
AGCCACGCCTTTCCATTTTTCAATGCTGCATATTTAATCTGCAACAAAAATGTTAAGCCATAACAGCCTTTTTATATTTTAGTTTGTCAC
CTTTGCATTGCAGAATAAATACTGAATAACCATTTTTATAAGCAGTTGCTCCTCTTTGCATGGTTCTATTCTCTAAAAGTGTTGAATGAT
ACAGCCATTGCACTGAAGTTTGAGCTGTGTGCGTGTGAATTTATACTGTTTCAAAAATTTCAAATGCATGGTAGCATGTAGAAAGGTTTT
TGTTACTATGTGTGTGTGTGTGTTTTGTTTTGTTTTGTTCTGTTTTTTAACGTTCTTTCACCTTTCCTCTACTTTGGCTTTGCAAATTTC
AGTCTGTAGAGCCTGAAATTAAATTATTTTATAGTGCCTGATATTTTTAATATTATAAGTTGGATTCAAAGGGTATACAGCATTTTGTTT
TCTAGTACCATTGCTTCACTGGGAGCTCAAAATTTGCCTCCCTGTTAGTCTTTAATAACTGAGTAGAGTAGCTTTTTTATTCTTAGATTA
TAGTGATATTCTGTAGTGCTTCAAATACTTAGAATTCTAATATGAGAGATAGTTTAATATTCTGGAATAGAGAGTATTTTAAATTGAAAT
GACCAAATTCGATTTAAAACAAACACATAACAATCTTCAGTAAAGTTATTTGAACCTGTGGTTGACAATTCTGTATTGACTAAAGGCAAT
ATTGTCACCTGTCTCATTAAAAATTAGTTTCCAGTTAGGCAGATGAATAACACTATTAAAAATGCACCCAGTTTTGTAGTCACTTGACTT
TTTTTTTTTATTTAAATGAAATTTAATTTGAAAATAGAAAATAAAATTAGGTAAATATGACTGGCAACCTGAATTTGAGTTGGGATTCTT
TGTGTATTTTTCCCCCTTGAGGTTATTGTTTCTTCCTAATTTATATTTCAGATACATAGTGTAGAACAGGAATTTGCAGAAGCCATTTAA
GTTATCTTTTGAGGTAAGCTCTGATTTAGCATTTATTCTGATAAAATCTAATACATCATGGGATATATATAAAGCAACTTAATTCTTGTG
GTGTAGTCTTAATAGTTTTGAATGTTGACTGAATGTCTATAAAATTGTGAGTTTGTCTTTGTTACATTCCAGTGTTTCTGCCTCTTGGCA
TGCTTAAAGCACGGCTTACTTCATCTGCTCCTTACACACTAAAATGCTGTTAGTGTGCTCAACTACAGAAATAGCCGCTGCTAAGTGATG
TAGATTTTCTACTTGAATATTTTTATGTTGTAGGAACCTCAGGAGGTCAGTGTTTACTGTTTTATATATGCCTTCTTTTTCCTGTTTGAG
CTTCTCTCTTTGAAGGATTCTAACAGAACAAAGCTGCTGATCAACCTAAGTTGGAAACAGAAAGTGTAATTAATATAACTTAAATGCATG
TTTGGCAGTTCCATGTTACAGTCCATTAGCGAGTGAACTTAGTGCCACAGGTATTCATTTATTCAGGAAAGAATTTTGCTTTTTGTATTG
TCTAATCTCTTCAATGACTTCATACTGTGTAAAAAAAAATCACTTTTTAATATTTTTTGGTTGGTTATTTCCCAAATAATCAACATGTAA
ATAATCTTTTAAGAGCCAGTTCTGATGCTTTACATTATTGCTACTTGATTTTGTTATGCAAGTTAGATTTCAGAAGAATAGATTTTAAAA
CACTTAACCAAGCCATTACATCTTAAAAACAAAACAAGTAGCATACATTTTGTAATTAACATTGATAAACACTGTGATTTTTTTGGTTAA
GACTTTTTCATTGATCTGAATTGCTTAAATTGCATATATTGTAAAATAGGATCAGATGTATATTTTAAACTAATTTCAATGGATTTTCCT
CTTGAAATGCTTTGTCTACTCAGTTATAAAATATTCAGATACAAGTTTTATCTCAGGTGAATACTCTTGTATTGTTTTTGCTTTGGTGAC
ATGCTTATAAAGGGTCATCCTAGTTACATTCTTTGTTTTTTAAGTGTATTTCATTGAGAATCTTTCCATTTAGTCTGATTTTTTTCCTAA
TATTCTAGCAGGCTGGGGTGGTATAAAGCCCTCCTGACAAGCCTTTTGCCTACAGGTTTACCTGAAAATGAGCTACATATGGTCGTCATT
TTCTTCAAACTCTCAAAATAGGAAAGTGGAAATTTTTCTCCCCTATATAAAATTATTCTGCCTAGCAGAAATGCCAGAAATAAATTAATT
GCATCTTAGTCTAAATTTAAGTCCTTTGCCATGAGGAAAAAGTGGTTTTTTGCTTCATATGGTAAATCTATATTATTCATATTGAATGTA
TTAACAGATAATGGTGCAAAAGCATTCTTCCCAGGGGAAGAGTGTATCATGCATAACTGCAATTTAAGTCCTTCCTTTGATAATACTTCA
AAACATACACAGCTTTGCTTACTGAATTATTTTTGCAAATAATACAAGGAGGGGAAACTAACTTGCTACTAGTGTTGTTAATGAAGTATA
GGCCTTGGAACATTTAAGAAAACTGGTCTTCAGATAGTTAAGGGCTTGGGATAATTTAAGTGAAAAGTGAGATCAGTAATGAGCTGTGTT
GTTAACAATATTATCTGGTAATAATACCATGCAATATAGCGTTGTATACCAACTTAGTGCATTTTATACTGTATTAAATATGGAGATACT
TCTAATGCCTCTCTAAAATTAAATTTTACATAAAAGTTAGTTTTATTCACCTTTAGGCTTTCCAAGTGAATTGTGACTAATTTTTTCAAT
CTTACATAGATCTTTCACCCATTAGCATTACTTACGTAGATAATTCTTTATGCCTAGTTATTATACATATTAATTTTTAAGGTATACATT
TAAATTACACAATTGTTCATTGTGGTTTGTATCCCAGAATGTGTTGTGTTTTTTAAAAGATGCATAATAGCTGAATGTATGCATGACTTT
GAAAGAAGTTAAAATGGTGATTTTTTTTCACCTCTTGTACATTTTAAAACCAGGCCAAATCTATTTGCCAAGCAGTGTATCACTAATAAG
AAAAGCAGTTTTTCCTTTTATTGCAGTTTTTGTTTATCTGCCATAGAATTTCCTTATACTGTGGCTTGGTATTATTCAAGATTAGCTATT
TCGCTGGTATTACATCTTTTTAAAAGCCTATTATAACATGGTTAGCCTATAAGGCAGTGTTGGTCCCCTTCTAATATTGGCCTCATAAAG
GGGTTCCACTGTACTTTCCGCATATTACTGTGTTGTTGTTTTCCTTTGTGGATATATAAGCAAATTGAGCTTGGGTGATTTTTATGGAGA
CAATAATTAGACAATACTGTATAATTAGTTTTACTTAATAGATTATCATCTTGTGAGAAGAGATGTTTAAACGTGGTAAATCACTTCATA
TTACAAAACAGTTTTACACTTAATATGTTAACATTGGGTGCAATAATTTAGTAGCATTAGCTTTAGTTACAAATATAACTGGATCTTTCT
GCTGACAACTTAGGTTGTATGAGTTATGCTTAAAAGCTTTAAATCTGATGTTTCCTGTACCTGCCACACTATGTTAGAATGTGTCCTTCA
AACATATCCTCCTGCAACTTCTCAAACTGTACTAAATTGATATTTCTTGAAGTCTAACTCTGTGCTAACAGATCTCCATTTTAAATAGAA
TACGGTTTTAATTTTTGATAAGCTGCTGAATTTTAAAGAGAGTTTTTTGGGGCCACCAAATATTTTGGATCATGCAGAGAATATATATTG
TACTGTAGTAATTTTGTATTTACATTTGTATGATGTGACATAATAGATGTGAATGTTAATCACTGCTTGACTATGTTAATAAAGTTGTTT

>61533_61533_4_OPA3-TNPO1_OPA3_chr19_46087881_ENST00000323060_TNPO1_chr5_72144212_ENST00000454282_length(amino acids)=868AA_BP=23
MPTVLRRPPAEASSSRPISASRRLNQTKMEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEGI
LITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVNQFI
ISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDV
LVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDEDGIEEEDDDDDEIDDDDTISDWNLRKCSAAA
LDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQ
PPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYI
QMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLA
EGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFISVCNNATWAIGEISIQMGIE
MQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDF

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Fusion Gene PPI Analysis for OPA3-TNPO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for OPA3-TNPO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for OPA3-TNPO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource