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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGAP8-XRCC6 (FusionGDB2 ID:6158)

Fusion Gene Summary for ARHGAP8-XRCC6

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP8-XRCC6
Fusion gene ID: 6158
HgeneTgene
Gene symbol

ARHGAP8

XRCC6

Gene ID

23779

2547

Gene nameRho GTPase activating protein 8X-ray repair cross complementing 6
SynonymsBPGAP1|PP610CTC75|CTCBF|G22P1|KU70|ML8|TLAA
Cytomap

22q13.31

22q13.2

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 8BCH domain-containing Cdc42GAP-like proteinBNIP-2 and Cdc42GAP homology domain-containing, proline-rich and Cdc42GAP-like protein subtype-1rho-type GTPase-activating protein 8X-ray repair cross-complementing protein 65'-dRP lyase Ku705'-deoxyribose-5-phosphate lyase Ku7070 kDa subunit of Ku antigenATP-dependent DNA helicase 2 subunit 1ATP-dependent DNA helicase II, 70 kDa subunitCTC box binding factor 75 kDa subunitDNA
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000336963, ENST00000356099, 
ENST00000389773, ENST00000389774, 
ENST00000517296, ENST00000469872, 
ENST00000359308, ENST00000360079, 
ENST00000402580, ENST00000405506, 
ENST00000405878, ENST00000428575, 
Fusion gene scores* DoF score5 X 6 X 5=1505 X 5 X 2=50
# samples 54
** MAII scorelog2(5/150*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/50*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP8 [Title/Abstract] AND XRCC6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP8(45182486)-XRCC6(42057335), # samples:1
ARHGAP8(45182486)-XRCC6(42054256), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGAP8

GO:0070374

positive regulation of ERK1 and ERK2 cascade

20179103

TgeneXRCC6

GO:0002218

activation of innate immune response

28712728

TgeneXRCC6

GO:0045860

positive regulation of protein kinase activity

22504299

TgeneXRCC6

GO:0045893

positive regulation of transcription, DNA-templated

12145306

TgeneXRCC6

GO:0071480

cellular response to gamma radiation

26359349

TgeneXRCC6

GO:0097680

double-strand break repair via classical nonhomologous end joining

24095731


check buttonFusion gene breakpoints across ARHGAP8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across XRCC6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-55-A4DG-01AARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
ChimerDB4LUADTCGA-55-A4DG-01AARHGAP8chr22

45182486

+XRCC6chr22

42057335

+


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Fusion Gene ORF analysis for ARHGAP8-XRCC6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000336963ENST00000359308ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000336963ENST00000360079ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000336963ENST00000402580ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000336963ENST00000405506ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000336963ENST00000405878ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000336963ENST00000428575ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000356099ENST00000359308ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000356099ENST00000360079ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000356099ENST00000402580ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000356099ENST00000405506ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000356099ENST00000405878ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000356099ENST00000428575ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000389773ENST00000359308ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000389773ENST00000360079ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000389773ENST00000402580ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000389773ENST00000405506ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000389773ENST00000405878ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000389773ENST00000428575ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000389774ENST00000359308ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000389774ENST00000360079ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000389774ENST00000402580ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000389774ENST00000405506ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000389774ENST00000405878ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000389774ENST00000428575ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000517296ENST00000359308ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000517296ENST00000360079ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000517296ENST00000402580ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000517296ENST00000405506ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000517296ENST00000405878ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
Frame-shiftENST00000517296ENST00000428575ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
In-frameENST00000336963ENST00000359308ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000336963ENST00000360079ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000336963ENST00000402580ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000336963ENST00000405506ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000336963ENST00000405878ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000336963ENST00000428575ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000356099ENST00000359308ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000356099ENST00000360079ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000356099ENST00000402580ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000356099ENST00000405506ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000356099ENST00000405878ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000356099ENST00000428575ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000389773ENST00000359308ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000389773ENST00000360079ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000389773ENST00000402580ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000389773ENST00000405506ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000389773ENST00000405878ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000389773ENST00000428575ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000389774ENST00000359308ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000389774ENST00000360079ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000389774ENST00000402580ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000389774ENST00000405506ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000389774ENST00000405878ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000389774ENST00000428575ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000517296ENST00000359308ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000517296ENST00000360079ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000517296ENST00000402580ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000517296ENST00000405506ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000517296ENST00000405878ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
In-frameENST00000517296ENST00000428575ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
intron-3CDSENST00000469872ENST00000359308ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
intron-3CDSENST00000469872ENST00000359308ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
intron-3CDSENST00000469872ENST00000360079ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
intron-3CDSENST00000469872ENST00000360079ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
intron-3CDSENST00000469872ENST00000402580ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
intron-3CDSENST00000469872ENST00000402580ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
intron-3CDSENST00000469872ENST00000405506ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
intron-3CDSENST00000469872ENST00000405506ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
intron-3CDSENST00000469872ENST00000405878ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
intron-3CDSENST00000469872ENST00000405878ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+
intron-3CDSENST00000469872ENST00000428575ARHGAP8chr22

45182486

+XRCC6chr22

42054256

+
intron-3CDSENST00000469872ENST00000428575ARHGAP8chr22

45182486

+XRCC6chr22

42057335

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000517296ARHGAP8chr2245182486+ENST00000360079XRCC6chr2242057335+137384101148382
ENST00000517296ARHGAP8chr2245182486+ENST00000402580XRCC6chr2242057335+137484101148382
ENST00000517296ARHGAP8chr2245182486+ENST00000428575XRCC6chr2242057335+137284101148382
ENST00000517296ARHGAP8chr2245182486+ENST00000359308XRCC6chr2242057335+137384101148382
ENST00000517296ARHGAP8chr2245182486+ENST00000405878XRCC6chr2242057335+137384101148382
ENST00000517296ARHGAP8chr2245182486+ENST00000405506XRCC6chr2242057335+136884101148382
ENST00000389773ARHGAP8chr2245182486+ENST00000360079XRCC6chr2242057335+9774450752250
ENST00000389773ARHGAP8chr2245182486+ENST00000402580XRCC6chr2242057335+9784450752250
ENST00000389773ARHGAP8chr2245182486+ENST00000428575XRCC6chr2242057335+9764450752250
ENST00000389773ARHGAP8chr2245182486+ENST00000359308XRCC6chr2242057335+9774450752250
ENST00000389773ARHGAP8chr2245182486+ENST00000405878XRCC6chr2242057335+9774450752250
ENST00000389773ARHGAP8chr2245182486+ENST00000405506XRCC6chr2242057335+9724450752250
ENST00000389774ARHGAP8chr2245182486+ENST00000360079XRCC6chr2242057335+75222072527151
ENST00000389774ARHGAP8chr2245182486+ENST00000402580XRCC6chr2242057335+75322072527151
ENST00000389774ARHGAP8chr2245182486+ENST00000428575XRCC6chr2242057335+75122072527151
ENST00000389774ARHGAP8chr2245182486+ENST00000359308XRCC6chr2242057335+75222072527151
ENST00000389774ARHGAP8chr2245182486+ENST00000405878XRCC6chr2242057335+75222072527151
ENST00000389774ARHGAP8chr2245182486+ENST00000405506XRCC6chr2242057335+74722072527151
ENST00000336963ARHGAP8chr2245182486+ENST00000360079XRCC6chr2242057335+70717527482151
ENST00000336963ARHGAP8chr2245182486+ENST00000402580XRCC6chr2242057335+70817527482151
ENST00000336963ARHGAP8chr2245182486+ENST00000428575XRCC6chr2242057335+70617527482151
ENST00000336963ARHGAP8chr2245182486+ENST00000359308XRCC6chr2242057335+70717527482151
ENST00000336963ARHGAP8chr2245182486+ENST00000405878XRCC6chr2242057335+70717527482151
ENST00000336963ARHGAP8chr2245182486+ENST00000405506XRCC6chr2242057335+70217527482151
ENST00000356099ARHGAP8chr2245182486+ENST00000360079XRCC6chr2242057335+70417224479151
ENST00000356099ARHGAP8chr2245182486+ENST00000402580XRCC6chr2242057335+70517224479151
ENST00000356099ARHGAP8chr2245182486+ENST00000428575XRCC6chr2242057335+70317224479151
ENST00000356099ARHGAP8chr2245182486+ENST00000359308XRCC6chr2242057335+70417224479151
ENST00000356099ARHGAP8chr2245182486+ENST00000405878XRCC6chr2242057335+70417224479151
ENST00000356099ARHGAP8chr2245182486+ENST00000405506XRCC6chr2242057335+69917224479151

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000517296ENST00000360079ARHGAP8chr2245182486+XRCC6chr2242057335+0.0048833430.9951167
ENST00000517296ENST00000402580ARHGAP8chr2245182486+XRCC6chr2242057335+0.0048559360.9951441
ENST00000517296ENST00000428575ARHGAP8chr2245182486+XRCC6chr2242057335+0.0048422290.9951578
ENST00000517296ENST00000359308ARHGAP8chr2245182486+XRCC6chr2242057335+0.0048833430.9951167
ENST00000517296ENST00000405878ARHGAP8chr2245182486+XRCC6chr2242057335+0.0048833430.9951167
ENST00000517296ENST00000405506ARHGAP8chr2245182486+XRCC6chr2242057335+0.0049735550.9950264
ENST00000389773ENST00000360079ARHGAP8chr2245182486+XRCC6chr2242057335+0.0055570410.994443
ENST00000389773ENST00000402580ARHGAP8chr2245182486+XRCC6chr2242057335+0.0054641930.9945358
ENST00000389773ENST00000428575ARHGAP8chr2245182486+XRCC6chr2242057335+0.0055948310.99440515
ENST00000389773ENST00000359308ARHGAP8chr2245182486+XRCC6chr2242057335+0.0055570410.994443
ENST00000389773ENST00000405878ARHGAP8chr2245182486+XRCC6chr2242057335+0.0055570410.994443
ENST00000389773ENST00000405506ARHGAP8chr2245182486+XRCC6chr2242057335+0.0056854380.9943145
ENST00000389774ENST00000360079ARHGAP8chr2245182486+XRCC6chr2242057335+0.0166455940.9833544
ENST00000389774ENST00000402580ARHGAP8chr2245182486+XRCC6chr2242057335+0.0162395430.9837605
ENST00000389774ENST00000428575ARHGAP8chr2245182486+XRCC6chr2242057335+0.016490110.98350996
ENST00000389774ENST00000359308ARHGAP8chr2245182486+XRCC6chr2242057335+0.0166455940.9833544
ENST00000389774ENST00000405878ARHGAP8chr2245182486+XRCC6chr2242057335+0.0166455940.9833544
ENST00000389774ENST00000405506ARHGAP8chr2245182486+XRCC6chr2242057335+0.0164076020.9835924
ENST00000336963ENST00000360079ARHGAP8chr2245182486+XRCC6chr2242057335+0.016819560.98318046
ENST00000336963ENST00000402580ARHGAP8chr2245182486+XRCC6chr2242057335+0.0163345730.9836654
ENST00000336963ENST00000428575ARHGAP8chr2245182486+XRCC6chr2242057335+0.0170723270.98292774
ENST00000336963ENST00000359308ARHGAP8chr2245182486+XRCC6chr2242057335+0.016819560.98318046
ENST00000336963ENST00000405878ARHGAP8chr2245182486+XRCC6chr2242057335+0.016819560.98318046
ENST00000336963ENST00000405506ARHGAP8chr2245182486+XRCC6chr2242057335+0.0168340360.983166
ENST00000356099ENST00000360079ARHGAP8chr2245182486+XRCC6chr2242057335+0.0166000520.9833999
ENST00000356099ENST00000402580ARHGAP8chr2245182486+XRCC6chr2242057335+0.0162089630.98379105
ENST00000356099ENST00000428575ARHGAP8chr2245182486+XRCC6chr2242057335+0.0168295760.98317045
ENST00000356099ENST00000359308ARHGAP8chr2245182486+XRCC6chr2242057335+0.0166000520.9833999
ENST00000356099ENST00000405878ARHGAP8chr2245182486+XRCC6chr2242057335+0.0166000520.9833999
ENST00000356099ENST00000405506ARHGAP8chr2245182486+XRCC6chr2242057335+0.016610110.9833899

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Fusion Genomic Features for ARHGAP8-XRCC6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARHGAP8chr2245182486+XRCC6chr2242057334+2.65E-060.9999974
ARHGAP8chr2245182486+XRCC6chr2242054255+2.16E-091
ARHGAP8chr2245182486+XRCC6chr2242057334+2.65E-060.9999974
ARHGAP8chr2245182486+XRCC6chr2242054255+2.16E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARHGAP8-XRCC6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:45182486/chr22:42057335)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

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* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneXRCC6chr22:45182486chr22:42057335ENST00000359308912573_607507610.0DomainSAP
TgeneXRCC6chr22:45182486chr22:42057335ENST000003600791013573_607507610.0DomainSAP
TgeneXRCC6chr22:45182486chr22:42057335ENST000004058781013573_607507610.0DomainSAP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP8chr22:45182486chr22:42057335ENST00000356099+21213_19926434.0DomainCRAL-TRIO
HgeneARHGAP8chr22:45182486chr22:42057335ENST00000356099+212226_41226434.0DomainRho-GAP
HgeneARHGAP8chr22:45182486chr22:42057335ENST00000389774+21313_19926465.0DomainCRAL-TRIO
HgeneARHGAP8chr22:45182486chr22:42057335ENST00000389774+213226_41226465.0DomainRho-GAP
TgeneXRCC6chr22:45182486chr22:42057335ENST0000035930891211_29507610.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneXRCC6chr22:45182486chr22:42057335ENST000003593089122_61507610.0Compositional biasNote=Ser-rich (potentially targets for phosphorylation)
TgeneXRCC6chr22:45182486chr22:42057335ENST00000359308912330_342507610.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneXRCC6chr22:45182486chr22:42057335ENST00000360079101311_29507610.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneXRCC6chr22:45182486chr22:42057335ENST0000036007910132_61507610.0Compositional biasNote=Ser-rich (potentially targets for phosphorylation)
TgeneXRCC6chr22:45182486chr22:42057335ENST000003600791013330_342507610.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneXRCC6chr22:45182486chr22:42057335ENST00000405878101311_29507610.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneXRCC6chr22:45182486chr22:42057335ENST0000040587810132_61507610.0Compositional biasNote=Ser-rich (potentially targets for phosphorylation)
TgeneXRCC6chr22:45182486chr22:42057335ENST000004058781013330_342507610.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneXRCC6chr22:45182486chr22:42057335ENST00000359308912261_468507610.0DomainNote=Ku
TgeneXRCC6chr22:45182486chr22:42057335ENST000003600791013261_468507610.0DomainNote=Ku
TgeneXRCC6chr22:45182486chr22:42057335ENST000004058781013261_468507610.0DomainNote=Ku


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Fusion Gene Sequence for ARHGAP8-XRCC6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6158_6158_1_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000336963_XRCC6_chr22_42057335_ENST00000359308_length(transcript)=707nt_BP=175nt
GGGGGCCGGCGGGGTCCGTGGCCAGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTG
GTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCC
AAGGTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAA
GTTACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTGGAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGC
AAGGGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCCTGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTG
CTGGAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCGCGTCCAGCTGCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGT
CCTCAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTACCCGACATAAGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTG

>6158_6158_1_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000336963_XRCC6_chr22_42057335_ENST00000359308_length(amino acids)=151AA_BP=49
MQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNE

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>6158_6158_2_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000336963_XRCC6_chr22_42057335_ENST00000360079_length(transcript)=707nt_BP=175nt
GGGGGCCGGCGGGGTCCGTGGCCAGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTG
GTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCC
AAGGTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAA
GTTACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTGGAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGC
AAGGGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCCTGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTG
CTGGAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCGCGTCCAGCTGCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGT
CCTCAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTACCCGACATAAGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTG

>6158_6158_2_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000336963_XRCC6_chr22_42057335_ENST00000360079_length(amino acids)=151AA_BP=49
MQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNE

--------------------------------------------------------------
>6158_6158_3_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000336963_XRCC6_chr22_42057335_ENST00000402580_length(transcript)=708nt_BP=175nt
GGGGGCCGGCGGGGTCCGTGGCCAGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTG
GTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCC
AAGGTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAA
GTTACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTGGAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGC
AAGGGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCCTGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTG
CTGGAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCGCGTCCAGCTGCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGT
CCTCAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTACCCGACATAAGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTG

>6158_6158_3_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000336963_XRCC6_chr22_42057335_ENST00000402580_length(amino acids)=151AA_BP=49
MQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNE

--------------------------------------------------------------
>6158_6158_4_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000336963_XRCC6_chr22_42057335_ENST00000405506_length(transcript)=702nt_BP=175nt
GGGGGCCGGCGGGGTCCGTGGCCAGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTG
GTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCC
AAGGTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAA
GTTACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTGGAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGC
AAGGGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCCTGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTG
CTGGAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCGCGTCCAGCTGCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGT
CCTCAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTACCCGACATAAGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTG

>6158_6158_4_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000336963_XRCC6_chr22_42057335_ENST00000405506_length(amino acids)=151AA_BP=49
MQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNE

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>6158_6158_5_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000336963_XRCC6_chr22_42057335_ENST00000405878_length(transcript)=707nt_BP=175nt
GGGGGCCGGCGGGGTCCGTGGCCAGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTG
GTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCC
AAGGTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAA
GTTACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTGGAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGC
AAGGGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCCTGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTG
CTGGAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCGCGTCCAGCTGCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGT
CCTCAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTACCCGACATAAGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTG

>6158_6158_5_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000336963_XRCC6_chr22_42057335_ENST00000405878_length(amino acids)=151AA_BP=49
MQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNE

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>6158_6158_6_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000336963_XRCC6_chr22_42057335_ENST00000428575_length(transcript)=706nt_BP=175nt
GGGGGCCGGCGGGGTCCGTGGCCAGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTG
GTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCC
AAGGTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAA
GTTACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTGGAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGC
AAGGGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCCTGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTG
CTGGAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCGCGTCCAGCTGCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGT
CCTCAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTACCCGACATAAGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTG

>6158_6158_6_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000336963_XRCC6_chr22_42057335_ENST00000428575_length(amino acids)=151AA_BP=49
MQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNE

--------------------------------------------------------------
>6158_6158_7_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000356099_XRCC6_chr22_42057335_ENST00000359308_length(transcript)=704nt_BP=172nt
GGCCGGCGGGGTCCGTGGCCAGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTGGTG
CCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCCAAG
GTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAAGTT
ACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTGGAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGCAAG
GGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCCTGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTGCTG
GAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCGCGTCCAGCTGCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGTCCT
CAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTACCCGACATAAGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTGCCA

>6158_6158_7_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000356099_XRCC6_chr22_42057335_ENST00000359308_length(amino acids)=151AA_BP=49
MQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNE

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>6158_6158_8_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000356099_XRCC6_chr22_42057335_ENST00000360079_length(transcript)=704nt_BP=172nt
GGCCGGCGGGGTCCGTGGCCAGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTGGTG
CCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCCAAG
GTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAAGTT
ACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTGGAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGCAAG
GGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCCTGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTGCTG
GAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCGCGTCCAGCTGCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGTCCT
CAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTACCCGACATAAGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTGCCA

>6158_6158_8_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000356099_XRCC6_chr22_42057335_ENST00000360079_length(amino acids)=151AA_BP=49
MQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNE

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>6158_6158_9_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000356099_XRCC6_chr22_42057335_ENST00000402580_length(transcript)=705nt_BP=172nt
GGCCGGCGGGGTCCGTGGCCAGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTGGTG
CCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCCAAG
GTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAAGTT
ACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTGGAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGCAAG
GGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCCTGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTGCTG
GAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCGCGTCCAGCTGCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGTCCT
CAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTACCCGACATAAGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTGCCA

>6158_6158_9_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000356099_XRCC6_chr22_42057335_ENST00000402580_length(amino acids)=151AA_BP=49
MQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNE

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>6158_6158_10_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000356099_XRCC6_chr22_42057335_ENST00000405506_length(transcript)=699nt_BP=172nt
GGCCGGCGGGGTCCGTGGCCAGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTGGTG
CCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCCAAG
GTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAAGTT
ACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTGGAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGCAAG
GGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCCTGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTGCTG
GAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCGCGTCCAGCTGCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGTCCT
CAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTACCCGACATAAGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTGCCA

>6158_6158_10_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000356099_XRCC6_chr22_42057335_ENST00000405506_length(amino acids)=151AA_BP=49
MQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNE

--------------------------------------------------------------
>6158_6158_11_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000356099_XRCC6_chr22_42057335_ENST00000405878_length(transcript)=704nt_BP=172nt
GGCCGGCGGGGTCCGTGGCCAGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTGGTG
CCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCCAAG
GTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAAGTT
ACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTGGAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGCAAG
GGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCCTGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTGCTG
GAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCGCGTCCAGCTGCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGTCCT
CAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTACCCGACATAAGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTGCCA

>6158_6158_11_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000356099_XRCC6_chr22_42057335_ENST00000405878_length(amino acids)=151AA_BP=49
MQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNE

--------------------------------------------------------------
>6158_6158_12_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000356099_XRCC6_chr22_42057335_ENST00000428575_length(transcript)=703nt_BP=172nt
GGCCGGCGGGGTCCGTGGCCAGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTGGTG
CCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCCAAG
GTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAAGTT
ACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTGGAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGCAAG
GGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCCTGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTGCTG
GAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCGCGTCCAGCTGCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGTCCT
CAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTACCCGACATAAGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTGCCA

>6158_6158_12_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000356099_XRCC6_chr22_42057335_ENST00000428575_length(amino acids)=151AA_BP=49
MQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNE

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>6158_6158_13_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000389773_XRCC6_chr22_42057335_ENST00000359308_length(transcript)=977nt_BP=445nt
ATGAGTTCGCCCAGCCTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGACGAGCGGGGCACGCAGCAGCGCCGGGCCTGCGCC
AACGCCACCTGGAACAGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAG
GGCGTCCGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCCTT
CGGGACAAGATTCGCTTCTATGAGGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTG
GTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCC
AAGGTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAA
GTTACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTGGAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGC
AAGGGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCCTGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTG
CTGGAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCGCGTCCAGCTGCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGT
CCTCAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTACCCGACATAAGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTG

>6158_6158_13_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000389773_XRCC6_chr22_42057335_ENST00000359308_length(amino acids)=250AA_BP=148
MSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEELQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGK

--------------------------------------------------------------
>6158_6158_14_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000389773_XRCC6_chr22_42057335_ENST00000360079_length(transcript)=977nt_BP=445nt
ATGAGTTCGCCCAGCCTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGACGAGCGGGGCACGCAGCAGCGCCGGGCCTGCGCC
AACGCCACCTGGAACAGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAG
GGCGTCCGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCCTT
CGGGACAAGATTCGCTTCTATGAGGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTG
GTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCC
AAGGTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAA
GTTACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTGGAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGC
AAGGGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCCTGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTG
CTGGAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCGCGTCCAGCTGCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGT
CCTCAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTACCCGACATAAGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTG

>6158_6158_14_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000389773_XRCC6_chr22_42057335_ENST00000360079_length(amino acids)=250AA_BP=148
MSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEELQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGK

--------------------------------------------------------------
>6158_6158_15_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000389773_XRCC6_chr22_42057335_ENST00000402580_length(transcript)=978nt_BP=445nt
ATGAGTTCGCCCAGCCTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGACGAGCGGGGCACGCAGCAGCGCCGGGCCTGCGCC
AACGCCACCTGGAACAGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAG
GGCGTCCGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCCTT
CGGGACAAGATTCGCTTCTATGAGGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTG
GTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCC
AAGGTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAA
GTTACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTGGAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGC
AAGGGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCCTGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTG
CTGGAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCGCGTCCAGCTGCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGT
CCTCAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTACCCGACATAAGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTG

>6158_6158_15_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000389773_XRCC6_chr22_42057335_ENST00000402580_length(amino acids)=250AA_BP=148
MSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEELQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGK

--------------------------------------------------------------
>6158_6158_16_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000389773_XRCC6_chr22_42057335_ENST00000405506_length(transcript)=972nt_BP=445nt
ATGAGTTCGCCCAGCCTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGACGAGCGGGGCACGCAGCAGCGCCGGGCCTGCGCC
AACGCCACCTGGAACAGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAG
GGCGTCCGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCCTT
CGGGACAAGATTCGCTTCTATGAGGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTG
GTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCC
AAGGTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAA
GTTACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTGGAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGC
AAGGGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCCTGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTG
CTGGAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCGCGTCCAGCTGCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGT
CCTCAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTACCCGACATAAGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTG

>6158_6158_16_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000389773_XRCC6_chr22_42057335_ENST00000405506_length(amino acids)=250AA_BP=148
MSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEELQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGK

--------------------------------------------------------------
>6158_6158_17_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000389773_XRCC6_chr22_42057335_ENST00000405878_length(transcript)=977nt_BP=445nt
ATGAGTTCGCCCAGCCTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGACGAGCGGGGCACGCAGCAGCGCCGGGCCTGCGCC
AACGCCACCTGGAACAGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAG
GGCGTCCGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCCTT
CGGGACAAGATTCGCTTCTATGAGGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTG
GTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCC
AAGGTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAA
GTTACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTGGAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGC
AAGGGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCCTGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTG
CTGGAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCGCGTCCAGCTGCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGT
CCTCAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTACCCGACATAAGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTG

>6158_6158_17_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000389773_XRCC6_chr22_42057335_ENST00000405878_length(amino acids)=250AA_BP=148
MSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEELQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGK

--------------------------------------------------------------
>6158_6158_18_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000389773_XRCC6_chr22_42057335_ENST00000428575_length(transcript)=976nt_BP=445nt
ATGAGTTCGCCCAGCCTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGACGAGCGGGGCACGCAGCAGCGCCGGGCCTGCGCC
AACGCCACCTGGAACAGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAG
GGCGTCCGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCCTT
CGGGACAAGATTCGCTTCTATGAGGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTG
GTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCC
AAGGTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAA
GTTACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTGGAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGC
AAGGGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCCTGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTG
CTGGAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCGCGTCCAGCTGCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGT
CCTCAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTACCCGACATAAGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTG

>6158_6158_18_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000389773_XRCC6_chr22_42057335_ENST00000428575_length(amino acids)=250AA_BP=148
MSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEELQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGK

--------------------------------------------------------------
>6158_6158_19_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000389774_XRCC6_chr22_42057335_ENST00000359308_length(transcript)=752nt_BP=220nt
ACGTCCGGGGAGGGGCCAGGTGAGCGGCAGACCCGGCACGCAGGTGGGGGCCGGCGGGGTCCGTGGCCAGAGCTGCAGAGAGACAAGGCG
GCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTGGTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCG
TTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCCAAGGTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAG
TTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAAGTTACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGG
CCCAAGGTGGAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGCAAGGGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCC
TGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTGCTGGAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCG
CGTCCAGCTGCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGTCCTCAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTA
CCCGACATAAGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTGCCATGGTGATGGTGTAGCCCTCCCACTTTGCTGTTCCTTACTTTA

>6158_6158_19_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000389774_XRCC6_chr22_42057335_ENST00000359308_length(amino acids)=151AA_BP=49
MQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNE

--------------------------------------------------------------
>6158_6158_20_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000389774_XRCC6_chr22_42057335_ENST00000360079_length(transcript)=752nt_BP=220nt
ACGTCCGGGGAGGGGCCAGGTGAGCGGCAGACCCGGCACGCAGGTGGGGGCCGGCGGGGTCCGTGGCCAGAGCTGCAGAGAGACAAGGCG
GCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTGGTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCG
TTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCCAAGGTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAG
TTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAAGTTACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGG
CCCAAGGTGGAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGCAAGGGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCC
TGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTGCTGGAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCG
CGTCCAGCTGCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGTCCTCAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTA
CCCGACATAAGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTGCCATGGTGATGGTGTAGCCCTCCCACTTTGCTGTTCCTTACTTTA

>6158_6158_20_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000389774_XRCC6_chr22_42057335_ENST00000360079_length(amino acids)=151AA_BP=49
MQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNE

--------------------------------------------------------------
>6158_6158_21_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000389774_XRCC6_chr22_42057335_ENST00000402580_length(transcript)=753nt_BP=220nt
ACGTCCGGGGAGGGGCCAGGTGAGCGGCAGACCCGGCACGCAGGTGGGGGCCGGCGGGGTCCGTGGCCAGAGCTGCAGAGAGACAAGGCG
GCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTGGTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCG
TTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCCAAGGTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAG
TTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAAGTTACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGG
CCCAAGGTGGAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGCAAGGGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCC
TGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTGCTGGAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCG
CGTCCAGCTGCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGTCCTCAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTA
CCCGACATAAGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTGCCATGGTGATGGTGTAGCCCTCCCACTTTGCTGTTCCTTACTTTA

>6158_6158_21_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000389774_XRCC6_chr22_42057335_ENST00000402580_length(amino acids)=151AA_BP=49
MQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNE

--------------------------------------------------------------
>6158_6158_22_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000389774_XRCC6_chr22_42057335_ENST00000405506_length(transcript)=747nt_BP=220nt
ACGTCCGGGGAGGGGCCAGGTGAGCGGCAGACCCGGCACGCAGGTGGGGGCCGGCGGGGTCCGTGGCCAGAGCTGCAGAGAGACAAGGCG
GCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTGGTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCG
TTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCCAAGGTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAG
TTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAAGTTACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGG
CCCAAGGTGGAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGCAAGGGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCC
TGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTGCTGGAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCG
CGTCCAGCTGCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGTCCTCAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTA
CCCGACATAAGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTGCCATGGTGATGGTGTAGCCCTCCCACTTTGCTGTTCCTTACTTTA

>6158_6158_22_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000389774_XRCC6_chr22_42057335_ENST00000405506_length(amino acids)=151AA_BP=49
MQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNE

--------------------------------------------------------------
>6158_6158_23_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000389774_XRCC6_chr22_42057335_ENST00000405878_length(transcript)=752nt_BP=220nt
ACGTCCGGGGAGGGGCCAGGTGAGCGGCAGACCCGGCACGCAGGTGGGGGCCGGCGGGGTCCGTGGCCAGAGCTGCAGAGAGACAAGGCG
GCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTGGTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCG
TTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCCAAGGTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAG
TTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAAGTTACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGG
CCCAAGGTGGAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGCAAGGGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCC
TGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTGCTGGAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCG
CGTCCAGCTGCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGTCCTCAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTA
CCCGACATAAGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTGCCATGGTGATGGTGTAGCCCTCCCACTTTGCTGTTCCTTACTTTA

>6158_6158_23_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000389774_XRCC6_chr22_42057335_ENST00000405878_length(amino acids)=151AA_BP=49
MQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNE

--------------------------------------------------------------
>6158_6158_24_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000389774_XRCC6_chr22_42057335_ENST00000428575_length(transcript)=751nt_BP=220nt
ACGTCCGGGGAGGGGCCAGGTGAGCGGCAGACCCGGCACGCAGGTGGGGGCCGGCGGGGTCCGTGGCCAGAGCTGCAGAGAGACAAGGCG
GCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTGGTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCG
TTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCCAAGGTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAG
TTTAAGGAGCTTGTTTACCCACCAGATTACAATCCTGAAGGGAAAGTTACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGG
CCCAAGGTGGAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGCAAGGGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCC
TGCCGGGCTTACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTGCTGGAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCG
CGTCCAGCTGCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGTCCTCAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTA
CCCGACATAAGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTGCCATGGTGATGGTGTAGCCCTCCCACTTTGCTGTTCCTTACTTTA

>6158_6158_24_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000389774_XRCC6_chr22_42057335_ENST00000428575_length(amino acids)=151AA_BP=49
MQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNE

--------------------------------------------------------------
>6158_6158_25_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000517296_XRCC6_chr22_42057335_ENST00000359308_length(transcript)=1373nt_BP=841nt
ATGAGGACTCTCCGCAGGTTGAAGTTCATGAGTTCGCCCAGCCTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGACGAGCGG
GGCACGCAGCAGCGCCGGGCCTGCGCCAACGCCACCTGGAACAGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCC
GACCAGGAGCTCTTCAGCCTCAACGAGGGCGTCCGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAG
CTGCTGACAAAAGGCATGGTGATCCTTCGGGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGAC
TTCTTCTTCAGTGACGTGCTGCCCATGCTGCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTG
CACTTCCGGAATGCCATCACCCTCAGTGTGAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATG
CTGCTGGTGCTGCAGGGGGTACATGAGTCCAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCA
TACCTGGGCACCTACGGCCTCCACTCCAGCGAGGGGCCCTTCACCCATTCCTGCATCCTGGAGCTGCAGAGAGACAAGGCGGCGGCGGCT
GCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTGGTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGAC
GTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCCAAGGTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAG
CTTGTTTACCCACCAGATTACAATCCTGAAGGGAAAGTTACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTG
GAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGCAAGGGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCCTGCCGGGCT
TACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTGCTGGAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCGCGTCCAGCT
GCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGTCCTCAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTACCCGACATA
AGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTGCCATGGTGATGGTGTAGCCCTCCCACTTTGCTGTTCCTTACTTTACTGCCTGAA

>6158_6158_25_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000517296_XRCC6_chr22_42057335_ENST00000359308_length(amino acids)=382AA_BP=280
MRTLRRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRQLLKTELGSFFTEYLQNQ
LLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQM
LLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILELQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYD
VARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNEGSGSKRPKVEYSEEELKTHISKGTLGKFTVPMLKEACRA

--------------------------------------------------------------
>6158_6158_26_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000517296_XRCC6_chr22_42057335_ENST00000360079_length(transcript)=1373nt_BP=841nt
ATGAGGACTCTCCGCAGGTTGAAGTTCATGAGTTCGCCCAGCCTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGACGAGCGG
GGCACGCAGCAGCGCCGGGCCTGCGCCAACGCCACCTGGAACAGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCC
GACCAGGAGCTCTTCAGCCTCAACGAGGGCGTCCGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAG
CTGCTGACAAAAGGCATGGTGATCCTTCGGGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGAC
TTCTTCTTCAGTGACGTGCTGCCCATGCTGCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTG
CACTTCCGGAATGCCATCACCCTCAGTGTGAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATG
CTGCTGGTGCTGCAGGGGGTACATGAGTCCAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCA
TACCTGGGCACCTACGGCCTCCACTCCAGCGAGGGGCCCTTCACCCATTCCTGCATCCTGGAGCTGCAGAGAGACAAGGCGGCGGCGGCT
GCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTGGTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGAC
GTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCCAAGGTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAG
CTTGTTTACCCACCAGATTACAATCCTGAAGGGAAAGTTACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTG
GAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGCAAGGGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCCTGCCGGGCT
TACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTGCTGGAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCGCGTCCAGCT
GCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGTCCTCAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTACCCGACATA
AGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTGCCATGGTGATGGTGTAGCCCTCCCACTTTGCTGTTCCTTACTTTACTGCCTGAA

>6158_6158_26_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000517296_XRCC6_chr22_42057335_ENST00000360079_length(amino acids)=382AA_BP=280
MRTLRRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRQLLKTELGSFFTEYLQNQ
LLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQM
LLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILELQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYD
VARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNEGSGSKRPKVEYSEEELKTHISKGTLGKFTVPMLKEACRA

--------------------------------------------------------------
>6158_6158_27_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000517296_XRCC6_chr22_42057335_ENST00000402580_length(transcript)=1374nt_BP=841nt
ATGAGGACTCTCCGCAGGTTGAAGTTCATGAGTTCGCCCAGCCTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGACGAGCGG
GGCACGCAGCAGCGCCGGGCCTGCGCCAACGCCACCTGGAACAGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCC
GACCAGGAGCTCTTCAGCCTCAACGAGGGCGTCCGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAG
CTGCTGACAAAAGGCATGGTGATCCTTCGGGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGAC
TTCTTCTTCAGTGACGTGCTGCCCATGCTGCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTG
CACTTCCGGAATGCCATCACCCTCAGTGTGAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATG
CTGCTGGTGCTGCAGGGGGTACATGAGTCCAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCA
TACCTGGGCACCTACGGCCTCCACTCCAGCGAGGGGCCCTTCACCCATTCCTGCATCCTGGAGCTGCAGAGAGACAAGGCGGCGGCGGCT
GCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTGGTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGAC
GTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCCAAGGTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAG
CTTGTTTACCCACCAGATTACAATCCTGAAGGGAAAGTTACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTG
GAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGCAAGGGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCCTGCCGGGCT
TACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTGCTGGAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCGCGTCCAGCT
GCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGTCCTCAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTACCCGACATA
AGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTGCCATGGTGATGGTGTAGCCCTCCCACTTTGCTGTTCCTTACTTTACTGCCTGAA

>6158_6158_27_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000517296_XRCC6_chr22_42057335_ENST00000402580_length(amino acids)=382AA_BP=280
MRTLRRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRQLLKTELGSFFTEYLQNQ
LLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQM
LLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILELQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYD
VARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNEGSGSKRPKVEYSEEELKTHISKGTLGKFTVPMLKEACRA

--------------------------------------------------------------
>6158_6158_28_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000517296_XRCC6_chr22_42057335_ENST00000405506_length(transcript)=1368nt_BP=841nt
ATGAGGACTCTCCGCAGGTTGAAGTTCATGAGTTCGCCCAGCCTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGACGAGCGG
GGCACGCAGCAGCGCCGGGCCTGCGCCAACGCCACCTGGAACAGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCC
GACCAGGAGCTCTTCAGCCTCAACGAGGGCGTCCGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAG
CTGCTGACAAAAGGCATGGTGATCCTTCGGGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGAC
TTCTTCTTCAGTGACGTGCTGCCCATGCTGCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTG
CACTTCCGGAATGCCATCACCCTCAGTGTGAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATG
CTGCTGGTGCTGCAGGGGGTACATGAGTCCAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCA
TACCTGGGCACCTACGGCCTCCACTCCAGCGAGGGGCCCTTCACCCATTCCTGCATCCTGGAGCTGCAGAGAGACAAGGCGGCGGCGGCT
GCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTGGTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGAC
GTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCCAAGGTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAG
CTTGTTTACCCACCAGATTACAATCCTGAAGGGAAAGTTACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTG
GAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGCAAGGGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCCTGCCGGGCT
TACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTGCTGGAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCGCGTCCAGCT
GCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGTCCTCAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTACCCGACATA
AGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTGCCATGGTGATGGTGTAGCCCTCCCACTTTGCTGTTCCTTACTTTACTGCCTGAA

>6158_6158_28_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000517296_XRCC6_chr22_42057335_ENST00000405506_length(amino acids)=382AA_BP=280
MRTLRRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRQLLKTELGSFFTEYLQNQ
LLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQM
LLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILELQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYD
VARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNEGSGSKRPKVEYSEEELKTHISKGTLGKFTVPMLKEACRA

--------------------------------------------------------------
>6158_6158_29_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000517296_XRCC6_chr22_42057335_ENST00000405878_length(transcript)=1373nt_BP=841nt
ATGAGGACTCTCCGCAGGTTGAAGTTCATGAGTTCGCCCAGCCTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGACGAGCGG
GGCACGCAGCAGCGCCGGGCCTGCGCCAACGCCACCTGGAACAGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCC
GACCAGGAGCTCTTCAGCCTCAACGAGGGCGTCCGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAG
CTGCTGACAAAAGGCATGGTGATCCTTCGGGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGAC
TTCTTCTTCAGTGACGTGCTGCCCATGCTGCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTG
CACTTCCGGAATGCCATCACCCTCAGTGTGAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATG
CTGCTGGTGCTGCAGGGGGTACATGAGTCCAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCA
TACCTGGGCACCTACGGCCTCCACTCCAGCGAGGGGCCCTTCACCCATTCCTGCATCCTGGAGCTGCAGAGAGACAAGGCGGCGGCGGCT
GCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTGGTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGAC
GTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCCAAGGTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAG
CTTGTTTACCCACCAGATTACAATCCTGAAGGGAAAGTTACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTG
GAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGCAAGGGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCCTGCCGGGCT
TACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTGCTGGAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCGCGTCCAGCT
GCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGTCCTCAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTACCCGACATA
AGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTGCCATGGTGATGGTGTAGCCCTCCCACTTTGCTGTTCCTTACTTTACTGCCTGAA

>6158_6158_29_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000517296_XRCC6_chr22_42057335_ENST00000405878_length(amino acids)=382AA_BP=280
MRTLRRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRQLLKTELGSFFTEYLQNQ
LLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQM
LLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILELQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYD
VARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNEGSGSKRPKVEYSEEELKTHISKGTLGKFTVPMLKEACRA

--------------------------------------------------------------
>6158_6158_30_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000517296_XRCC6_chr22_42057335_ENST00000428575_length(transcript)=1372nt_BP=841nt
ATGAGGACTCTCCGCAGGTTGAAGTTCATGAGTTCGCCCAGCCTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGACGAGCGG
GGCACGCAGCAGCGCCGGGCCTGCGCCAACGCCACCTGGAACAGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCC
GACCAGGAGCTCTTCAGCCTCAACGAGGGCGTCCGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAG
CTGCTGACAAAAGGCATGGTGATCCTTCGGGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGAC
TTCTTCTTCAGTGACGTGCTGCCCATGCTGCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTG
CACTTCCGGAATGCCATCACCCTCAGTGTGAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATG
CTGCTGGTGCTGCAGGGGGTACATGAGTCCAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCA
TACCTGGGCACCTACGGCCTCCACTCCAGCGAGGGGCCCTTCACCCATTCCTGCATCCTGGAGCTGCAGAGAGACAAGGCGGCGGCGGCT
GCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTGGTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGAC
GTGGCCAGACATGGCATTCTGCAGGTGGCAGTGCCCAAGGTTGAAGCAATGAATAAAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAG
CTTGTTTACCCACCAGATTACAATCCTGAAGGGAAAGTTACCAAGAGAAAACACGATAATGAAGGTTCTGGAAGCAAAAGGCCCAAGGTG
GAGTATTCAGAAGAGGAGCTGAAGACCCACATCAGCAAGGGTACGCTGGGCAAGTTCACTGTGCCCATGCTGAAAGAGGCCTGCCGGGCT
TACGGGCTGAAGAGTGGGCTGAAGAAGCAGGAGCTGCTGGAAGCCCTCACCAAGCACTTCCAGGACTGACCAGAGGCCGCGCGTCCAGCT
GCCCTTCCGCAGTGTGGCCAGGCTGCCTGGCCTTGTCCTCAGCCAGTTAAAATGTGTTTCTCCTGAGCTAGGAAGAGTCTACCCGACATA
AGTCGAGGGACTTTATGTTTTTGAGGCTTTCTGTTGCCATGGTGATGGTGTAGCCCTCCCACTTTGCTGTTCCTTACTTTACTGCCTGAA

>6158_6158_30_ARHGAP8-XRCC6_ARHGAP8_chr22_45182486_ENST00000517296_XRCC6_chr22_42057335_ENST00000428575_length(amino acids)=382AA_BP=280
MRTLRRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRQLLKTELGSFFTEYLQNQ
LLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQM
LLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILELQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYD
VARHGILQVAVPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNEGSGSKRPKVEYSEEELKTHISKGTLGKFTVPMLKEACRA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARHGAP8-XRCC6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneXRCC6chr22:45182486chr22:42057335ENST00000359308912550_609507.3333333333333610.0DEAF1
TgeneXRCC6chr22:45182486chr22:42057335ENST000003600791013550_609507.3333333333333610.0DEAF1
TgeneXRCC6chr22:45182486chr22:42057335ENST000004058781013550_609507.3333333333333610.0DEAF1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGAP8-XRCC6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGAP8-XRCC6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource