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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGDIA-ERBB3 (FusionGDB2 ID:6161)

Fusion Gene Summary for ARHGDIA-ERBB3

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGDIA-ERBB3
Fusion gene ID: 6161
HgeneTgene
Gene symbol

ARHGDIA

ERBB3

Gene ID

396

2065

Gene nameRho GDP dissociation inhibitor alphaerb-b2 receptor tyrosine kinase 3
SynonymsGDIA1|HEL-S-47e|NPHS8|RHOGDI|RHOGDI-1ErbB-3|FERLK|HER3|LCCS2|MDA-BF-1|c-erbB-3|c-erbB3|erbB3-S|p180-ErbB3|p45-sErbB3|p85-sErbB3
Cytomap

17q25.3

12q13.2

Type of geneprotein-codingprotein-coding
Descriptionrho GDP-dissociation inhibitor 1GDP-dissociation inhibitor, aplysia RAS-related 1Rho GDP dissociation inhibitor (GDI) alphaepididymis secretory sperm binding protein Li 47ereceptor tyrosine-protein kinase erbB-3human epidermal growth factor receptor 3proto-oncogene-like protein c-ErbB-3tyrosine kinase-type cell surface receptor HER3v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
Modification date2020032720200327
UniProtAcc

P52565

P21860

Ensembl transtripts involved in fusion geneENST00000269321, ENST00000582520, 
ENST00000400721, ENST00000541078, 
ENST00000580685, ENST00000581876, 
ENST00000584461, 		ENST00000267101, 
ENST00000411731, ENST00000415288, 
ENST00000450146, ENST00000549832, 
ENST00000553131, 
Fusion gene scores* DoF score7 X 4 X 4=11228 X 12 X 14=4704
# samples 728
** MAII scorelog2(7/112*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/4704*10)=-4.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGDIA [Title/Abstract] AND ERBB3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGDIA(79825598)-ERBB3(56492035), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneERBB3

GO:0007162

negative regulation of cell adhesion

7556068

TgeneERBB3

GO:0007165

signal transduction

10572067

TgeneERBB3

GO:0009968

negative regulation of signal transduction

11389077

TgeneERBB3

GO:0014065

phosphatidylinositol 3-kinase signaling

7556068

TgeneERBB3

GO:0042127

regulation of cell proliferation

11389077

TgeneERBB3

GO:0051048

negative regulation of secretion

10559227


check buttonFusion gene breakpoints across ARHGDIA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ERBB3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-BA-5555-01AARHGDIAchr17

79825598

-ERBB3chr12

56492035

+


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Fusion Gene ORF analysis for ARHGDIA-ERBB3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000269321ENST00000267101ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
5CDS-intronENST00000269321ENST00000411731ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
5CDS-intronENST00000269321ENST00000415288ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
5CDS-intronENST00000269321ENST00000450146ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
5CDS-intronENST00000269321ENST00000549832ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
5CDS-intronENST00000269321ENST00000553131ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
5CDS-intronENST00000582520ENST00000267101ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
5CDS-intronENST00000582520ENST00000411731ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
5CDS-intronENST00000582520ENST00000415288ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
5CDS-intronENST00000582520ENST00000450146ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
5CDS-intronENST00000582520ENST00000549832ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
5CDS-intronENST00000582520ENST00000553131ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000400721ENST00000267101ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000400721ENST00000411731ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000400721ENST00000415288ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000400721ENST00000450146ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000400721ENST00000549832ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000400721ENST00000553131ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000541078ENST00000267101ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000541078ENST00000411731ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000541078ENST00000415288ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000541078ENST00000450146ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000541078ENST00000549832ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000541078ENST00000553131ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000580685ENST00000267101ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000580685ENST00000411731ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000580685ENST00000415288ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000580685ENST00000450146ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000580685ENST00000549832ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000580685ENST00000553131ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000581876ENST00000267101ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000581876ENST00000411731ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000581876ENST00000415288ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000581876ENST00000450146ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000581876ENST00000549832ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000581876ENST00000553131ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000584461ENST00000267101ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000584461ENST00000411731ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000584461ENST00000415288ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000584461ENST00000450146ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000584461ENST00000549832ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+
intron-intronENST00000584461ENST00000553131ARHGDIAchr17

79825598

-ERBB3chr12

56492035

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ARHGDIA-ERBB3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARHGDIAchr1779825596-ERBB3chr1256492034+0.0007143840.99928564
ARHGDIAchr1779825596-ERBB3chr1256492034+0.0007143840.99928564

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARHGDIA-ERBB3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:79825598/:56492035)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGDIA

P52565

ERBB3

P21860

FUNCTION: Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269|PubMed:20400958, ECO:0000269|PubMed:23434736}.FUNCTION: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). {ECO:0000269|PubMed:15358134, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:27416908}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ARHGDIA-ERBB3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ARHGDIA-ERBB3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGDIA-ERBB3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGDIA-ERBB3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource