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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ORAI2-CUX1 (FusionGDB2 ID:61652)

Fusion Gene Summary for ORAI2-CUX1

check button Fusion gene summary
Fusion gene informationFusion gene name: ORAI2-CUX1
Fusion gene ID: 61652
HgeneTgene
Gene symbol

ORAI2

CUX1

Gene ID

80228

1523

Gene nameORAI calcium release-activated calcium modulator 2cut like homeobox 1
SynonymsC7orf19|CBCIP2|MEM142B|TMEM142BCASP|CDP|CDP/Cut|CDP1|COY1|CUTL1|CUX|Clox|Cux/CDP|GDDI|GOLIM6|Nbla10317|p100|p110|p200|p75
Cytomap

7q22.1

7q22.1

Type of geneprotein-codingprotein-coding
Descriptionprotein orai-2CAP-binding protein complex interacting protein 2H_NH0514P08.8putative protein ORAI2-2transmembrane protein 142Bprotein CASPHomeobox protein cut-like 1CCAAT displacement proteinCUX1 gene Alternatively Spliced Productcut homologgolgi integral membrane protein 6homeobox protein cux-1putative protein product of Nbla10317
Modification date2020031320200320
UniProtAcc.

P39880

Ensembl transtripts involved in fusion geneENST00000488996, ENST00000356387, 
ENST00000403646, ENST00000478730, 
ENST00000473939, 		ENST00000292538, 
ENST00000393824, ENST00000437600, 
ENST00000560541, ENST00000292535, 
ENST00000360264, ENST00000425244, 
ENST00000546411, ENST00000547394, 
ENST00000549414, ENST00000550008, 
ENST00000556210, 
Fusion gene scores* DoF score4 X 4 X 3=4826 X 23 X 9=5382
# samples 429
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(29/5382*10)=-4.21401758562548
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ORAI2 [Title/Abstract] AND CUX1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointORAI2(102074108)-CUX1(101671378), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ORAI2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CUX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DU-8165-01AORAI2chr7

102074108

-CUX1chr7

101671378

+
ChimerDB4LGGTCGA-DU-8165-01AORAI2chr7

102074108

+CUX1chr7

101671378

+
ChimerDB4LGGTCGA-DU-8165ORAI2chr7

102074108

+CUX1chr7

101671378

+


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Fusion Gene ORF analysis for ORAI2-CUX1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000488996ENST00000292538ORAI2chr7

102074108

+CUX1chr7

101671378

+
3UTR-3CDSENST00000488996ENST00000393824ORAI2chr7

102074108

+CUX1chr7

101671378

+
3UTR-3CDSENST00000488996ENST00000437600ORAI2chr7

102074108

+CUX1chr7

101671378

+
3UTR-3UTRENST00000488996ENST00000560541ORAI2chr7

102074108

+CUX1chr7

101671378

+
3UTR-intronENST00000488996ENST00000292535ORAI2chr7

102074108

+CUX1chr7

101671378

+
3UTR-intronENST00000488996ENST00000360264ORAI2chr7

102074108

+CUX1chr7

101671378

+
3UTR-intronENST00000488996ENST00000425244ORAI2chr7

102074108

+CUX1chr7

101671378

+
3UTR-intronENST00000488996ENST00000546411ORAI2chr7

102074108

+CUX1chr7

101671378

+
3UTR-intronENST00000488996ENST00000547394ORAI2chr7

102074108

+CUX1chr7

101671378

+
3UTR-intronENST00000488996ENST00000549414ORAI2chr7

102074108

+CUX1chr7

101671378

+
3UTR-intronENST00000488996ENST00000550008ORAI2chr7

102074108

+CUX1chr7

101671378

+
3UTR-intronENST00000488996ENST00000556210ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-3CDSENST00000356387ENST00000292538ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-3CDSENST00000356387ENST00000393824ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-3CDSENST00000356387ENST00000437600ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-3CDSENST00000403646ENST00000292538ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-3CDSENST00000403646ENST00000393824ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-3CDSENST00000403646ENST00000437600ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-3CDSENST00000478730ENST00000292538ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-3CDSENST00000478730ENST00000393824ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-3CDSENST00000478730ENST00000437600ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-3UTRENST00000356387ENST00000560541ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-3UTRENST00000403646ENST00000560541ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-3UTRENST00000478730ENST00000560541ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-intronENST00000356387ENST00000292535ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-intronENST00000356387ENST00000360264ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-intronENST00000356387ENST00000425244ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-intronENST00000356387ENST00000546411ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-intronENST00000356387ENST00000547394ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-intronENST00000356387ENST00000549414ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-intronENST00000356387ENST00000550008ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-intronENST00000356387ENST00000556210ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-intronENST00000403646ENST00000292535ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-intronENST00000403646ENST00000360264ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-intronENST00000403646ENST00000425244ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-intronENST00000403646ENST00000546411ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-intronENST00000403646ENST00000547394ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-intronENST00000403646ENST00000549414ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-intronENST00000403646ENST00000550008ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-intronENST00000403646ENST00000556210ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-intronENST00000478730ENST00000292535ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-intronENST00000478730ENST00000360264ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-intronENST00000478730ENST00000425244ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-intronENST00000478730ENST00000546411ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-intronENST00000478730ENST00000547394ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-intronENST00000478730ENST00000549414ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-intronENST00000478730ENST00000550008ORAI2chr7

102074108

+CUX1chr7

101671378

+
5UTR-intronENST00000478730ENST00000556210ORAI2chr7

102074108

+CUX1chr7

101671378

+
intron-3CDSENST00000473939ENST00000292538ORAI2chr7

102074108

+CUX1chr7

101671378

+
intron-3CDSENST00000473939ENST00000393824ORAI2chr7

102074108

+CUX1chr7

101671378

+
intron-3CDSENST00000473939ENST00000437600ORAI2chr7

102074108

+CUX1chr7

101671378

+
intron-3UTRENST00000473939ENST00000560541ORAI2chr7

102074108

+CUX1chr7

101671378

+
intron-intronENST00000473939ENST00000292535ORAI2chr7

102074108

+CUX1chr7

101671378

+
intron-intronENST00000473939ENST00000360264ORAI2chr7

102074108

+CUX1chr7

101671378

+
intron-intronENST00000473939ENST00000425244ORAI2chr7

102074108

+CUX1chr7

101671378

+
intron-intronENST00000473939ENST00000546411ORAI2chr7

102074108

+CUX1chr7

101671378

+
intron-intronENST00000473939ENST00000547394ORAI2chr7

102074108

+CUX1chr7

101671378

+
intron-intronENST00000473939ENST00000549414ORAI2chr7

102074108

+CUX1chr7

101671378

+
intron-intronENST00000473939ENST00000550008ORAI2chr7

102074108

+CUX1chr7

101671378

+
intron-intronENST00000473939ENST00000556210ORAI2chr7

102074108

+CUX1chr7

101671378

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ORAI2-CUX1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ORAI2chr7102074108+CUX1chr7101671377+1.53E-070.9999999
ORAI2chr7102074108+CUX1chr7101671377+1.53E-070.9999999
ORAI2chr7102074108+CUX1chr7101671377+1.53E-070.9999999
ORAI2chr7102074108+CUX1chr7101671377+1.53E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ORAI2-CUX1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:102074108/:101671378)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CUX1

P39880

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ORAI2-CUX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ORAI2-CUX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ORAI2-CUX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ORAI2-CUX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource