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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ORMDL3-PPP1R1B (FusionGDB2 ID:61712)

Fusion Gene Summary for ORMDL3-PPP1R1B

Fusion gene summary

Fusion gene information	Fusion gene name: ORMDL3-PPP1R1B
	Fusion gene ID: 61712
		Hgene	Tgene
	Gene symbol	ORMDL3	PPP1R1B
	Gene ID	94103	84152
	Gene name	ORMDL sphingolipid biosynthesis regulator 3	protein phosphatase 1 regulatory inhibitor subunit 1B
	Synonyms	-	DARPP-32\|DARPP32
	Cytomap	17q21.1	17q12
	Type of gene	protein-coding	protein-coding
	Description	ORM1-like protein 3	protein phosphatase 1 regulatory subunit 1Bdopamine and cAMP-regulated neuronal phosphoprotein 32
	Modification date	20200329	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000304046, ENST00000394169, ENST00000579695, ENST00000582052, ENST00000584220,	ENST00000394265, ENST00000394267, ENST00000254079, ENST00000579000, ENST00000580825,
Fusion gene scores	* DoF score	6 X 6 X 4=144	17 X 10 X 9=1530
	# samples	7	26
	** MAII score	log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(26/1530*10)=-2.55694812455156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ORMDL3 [Title/Abstract] AND PPP1R1B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ORMDL3(38080283)-PPP1R1B(37785423), # samples:2
Anticipated loss of major functional domain due to fusion event.	ORMDL3-PPP1R1B seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PPP1R1B	GO:0032515	negative regulation of phosphoprotein phosphatase activity	10807923

Fusion gene breakpoints across ORMDL3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PPP1R1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-D1-A3JP-01A	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+

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Fusion Gene ORF analysis for ORMDL3-PPP1R1B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000304046	ENST00000394265	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+
5CDS-5UTR	ENST00000304046	ENST00000394267	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+
5CDS-5UTR	ENST00000394169	ENST00000394265	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+
5CDS-5UTR	ENST00000394169	ENST00000394267	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+
5CDS-5UTR	ENST00000579695	ENST00000394265	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+
5CDS-5UTR	ENST00000579695	ENST00000394267	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+
Frame-shift	ENST00000579695	ENST00000254079	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+
Frame-shift	ENST00000579695	ENST00000579000	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+
Frame-shift	ENST00000579695	ENST00000580825	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+
In-frame	ENST00000304046	ENST00000254079	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+
In-frame	ENST00000304046	ENST00000579000	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+
In-frame	ENST00000304046	ENST00000580825	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+
In-frame	ENST00000394169	ENST00000254079	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+
In-frame	ENST00000394169	ENST00000579000	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+
In-frame	ENST00000394169	ENST00000580825	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+
intron-3CDS	ENST00000582052	ENST00000254079	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+
intron-3CDS	ENST00000582052	ENST00000579000	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+
intron-3CDS	ENST00000582052	ENST00000580825	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+
intron-3CDS	ENST00000584220	ENST00000254079	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+
intron-3CDS	ENST00000584220	ENST00000579000	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+
intron-3CDS	ENST00000584220	ENST00000580825	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+
intron-5UTR	ENST00000582052	ENST00000394265	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+
intron-5UTR	ENST00000582052	ENST00000394267	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+
intron-5UTR	ENST00000584220	ENST00000394265	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+
intron-5UTR	ENST00000584220	ENST00000394267	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000304046	ORMDL3	chr17	38080283	-	ENST00000580825	PPP1R1B	chr17	37785423	+	983	314	41	847	268
ENST00000304046	ORMDL3	chr17	38080283	-	ENST00000254079	PPP1R1B	chr17	37785423	+	1609	314	41	847	268
ENST00000304046	ORMDL3	chr17	38080283	-	ENST00000579000	PPP1R1B	chr17	37785423	+	1506	314	41	748	235
ENST00000394169	ORMDL3	chr17	38080283	-	ENST00000580825	PPP1R1B	chr17	37785423	+	2338	1669	1495	2202	235
ENST00000394169	ORMDL3	chr17	38080283	-	ENST00000254079	PPP1R1B	chr17	37785423	+	2964	1669	1495	2202	235
ENST00000394169	ORMDL3	chr17	38080283	-	ENST00000579000	PPP1R1B	chr17	37785423	+	2861	1669	1495	2103	202

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000304046	ENST00000580825	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+	0.010393483	0.98960644
ENST00000304046	ENST00000254079	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+	0.007576624	0.9924233
ENST00000304046	ENST00000579000	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+	0.007406845	0.9925931
ENST00000394169	ENST00000580825	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+	0.008073447	0.99192655
ENST00000394169	ENST00000254079	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+	0.005531914	0.9944681
ENST00000394169	ENST00000579000	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+	0.005726485	0.9942735

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Fusion Genomic Features for ORMDL3-PPP1R1B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ORMDL3	chr17	38080282	-	PPP1R1B	chr17	37785422	+	2.68E-05	0.9999732
ORMDL3	chr17	38080282	-	PPP1R1B	chr17	37785422	+	2.68E-05	0.9999732

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ORMDL3-PPP1R1B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:38080283/chr17:37785423)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ORMDL3

chr17:38080283

chr17:37785423

ENST00000304046

1_21

154.0

Topological domain

Cytoplasmic

Hgene

ORMDL3

chr17:38080283

chr17:37785423

ENST00000394169

1_21

154.0

Topological domain

Cytoplasmic

Hgene

ORMDL3

chr17:38080283

chr17:37785423

ENST00000579695

1_21

154.0

Topological domain

Cytoplasmic

Hgene

ORMDL3

chr17:38080283

chr17:37785423

ENST00000304046

22_42

154.0

Transmembrane

Helical

Hgene

ORMDL3

chr17:38080283

chr17:37785423

ENST00000394169

22_42

154.0

Transmembrane

Helical

Hgene

ORMDL3

chr17:38080283

chr17:37785423

ENST00000579695

22_42

154.0

Transmembrane

Helical

Tgene

PPP1R1B

chr17:38080283

chr17:37785423

ENST00000254079

119_136

205.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Tgene

PPP1R1B

chr17:38080283

chr17:37785423

ENST00000394265

119_136

169.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Tgene

PPP1R1B

chr17:38080283

chr17:37785423

ENST00000394267

119_136

169.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Tgene

PPP1R1B

chr17:38080283

chr17:37785423

ENST00000580825

119_136

205.0

Compositional bias

Note=Asp/Glu-rich (acidic)

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ORMDL3

chr17:38080283

chr17:37785423

ENST00000304046

118_153

154.0

Topological domain

Cytoplasmic

Hgene

ORMDL3

chr17:38080283

chr17:37785423

ENST00000304046

43_94

154.0

Topological domain

Lumenal

Hgene

ORMDL3

chr17:38080283

chr17:37785423

ENST00000394169

118_153

154.0

Topological domain

Cytoplasmic

Hgene

ORMDL3

chr17:38080283

chr17:37785423

ENST00000394169

43_94

154.0

Topological domain

Lumenal

Hgene

ORMDL3

chr17:38080283

chr17:37785423

ENST00000579695

118_153

154.0

Topological domain

Cytoplasmic

Hgene

ORMDL3

chr17:38080283

chr17:37785423

ENST00000579695

43_94

154.0

Topological domain

Lumenal

Hgene

ORMDL3

chr17:38080283

chr17:37785423

ENST00000584220

118_153

138.0

Topological domain

Cytoplasmic

Hgene

ORMDL3

chr17:38080283

chr17:37785423

ENST00000584220

1_21

138.0

Topological domain

Cytoplasmic

Hgene

ORMDL3

chr17:38080283

chr17:37785423

ENST00000584220

43_94

138.0

Topological domain

Lumenal

Hgene

ORMDL3

chr17:38080283

chr17:37785423

ENST00000304046

95_117

154.0

Transmembrane

Helical

Hgene

ORMDL3

chr17:38080283

chr17:37785423

ENST00000394169

95_117

154.0

Transmembrane

Helical

Hgene

ORMDL3

chr17:38080283

chr17:37785423

ENST00000579695

95_117

154.0

Transmembrane

Helical

Hgene

ORMDL3

chr17:38080283

chr17:37785423

ENST00000584220

22_42

138.0

Transmembrane

Helical

Hgene

ORMDL3

chr17:38080283

chr17:37785423

ENST00000584220

95_117

138.0

Transmembrane

Helical

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Fusion Gene Sequence for ORMDL3-PPP1R1B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>61712_61712_1_ORMDL3-PPP1R1B_ORMDL3_chr17_38080283_ENST00000304046_PPP1R1B_chr17_37785423_ENST00000254079_length(transcript)=1609nt_BP=314nt
GATTCGGCCGGAGCTGCCAGCGGGGAGGCTGCAGCCGCGGGTTGTTACAGCTGCTGGAGCAGCAGCGGCCCCCGCTCCCGGGAACCGTTC
CCGGGCCGTTGATCTTCGGCCCCACACGAACAGCAGAGAGGGGCAGCAGGATGAATGTGGGCACAGCGCACAGCGAGGTGAACCCCAACA
CGCGGGTGATGAACAGCCGTGGCATCTGGCTCTCCTACGTGCTGGCCATCGGTCTCCTCCACATCGTGCTGCTGAGCATCCCGTTTGTGA
GTGTCCCTGTCGTCTGGACCCTCACCAACCTCATTCACAACATGATCCGGCGCAGGAGACCAACGCCTGCCATGCTGTTCCGGCTCTCAG
AGCACTCCTCACCAGAGGAGGAAGCCTCCCCCCACCAGAGAGCCTCAGGAGAGGGGCACCATCTCAAGTCGAAGAGACCCAACCCCTGTG
CCTACACACCACCTTCGCTGAAAGCTGTGCAGCGCATTGCTGAGTCTCACCTGCAGTCTATCAGCAATTTGAATGAGAACCAGGCCTCAG
AGGAGGAGGATGAGCTGGGGGAGCTTCGGGAGCTGGGTTATCCAAGAGAGGAAGATGAGGAGGAAGAGGAGGATGATGAAGAAGAGGAAG
AAGAAGAGGACAGCCAGGCTGAAGTCCTGAAGGTCATCAGGCAGTCTGCTGGGCAAAAGACAACCTGTGGCCAGGGTCTGGAAGGGCCCT
GGGAGCGCCCACCCCCTCTGGATGAGTCCGAGAGAGATGGAGGCTCTGAGGACCAAGTGGAAGACCCAGCACTAAGTGAGCCTGGGGAGG
AACCTCAGCGCCCTTCCCCCTCTGAGCCTGGCACATAGGCACCCAGCCTGCATCTCCCAGGAGGAAGTGGAGGGGACATCGCTGTTCCCC
AGAAACCCACTCTATCCTCACCCTGTTTTGTGCTCTTCCCCTCGCCTGCTAGGGCTGCGGCTTCTGACTTCTAGAAGACTAAGGCTGGTC
TGTGTTTGCTTGTTTGCCCACCTTTGGCTGATACCCAGAGAACCTGGGCACTTGCTGCCTGATGCCCACCCCTGCCAGTCATTCCTCCAT
TCACCCAGCGGGAGGTGGGATGTGAGACAGCCCACATTGGAAAATCCAGAAAACCGGGAACAGGGATTTGCCCTTCACAATTCTACTCCC
CAGATCCTCTCCCCTGGACACAGGAGACCCACAGGGCAGGACCCTAAGATCTGGGGAAAGGAGGTCCTGAGAACCTTGAGGTACCCTTAG
ATCCTTTTCTACCCACTTTCCTATGGAGGATTCCAAGTCACCACTTCTCTCACCGGCTTCTACCAGGGTCCAGGACTAAGGCGTTTTTCT
CCATAGCCTCAACATTTTGGGAATCTTCCCTTAATCACCCTTGCTCCTCCTGGGTGCCTGGAAGATGGACTGGCAGAGACCTCTTTGTTG
CGTTTTGTGCTTTGATGCCAGGAATGCCGCCTAGTTTATGTCCCCGGTGGGGCACACAGCGGGGGGCGCCAGGTTTTCCTTGTCCCCCAG

>61712_61712_1_ORMDL3-PPP1R1B_ORMDL3_chr17_38080283_ENST00000304046_PPP1R1B_chr17_37785423_ENST00000254079_length(amino acids)=268AA_BP=91
MLQLLEQQRPPLPGTVPGPLIFGPTRTAERGSRMNVGTAHSEVNPNTRVMNSRGIWLSYVLAIGLLHIVLLSIPFVSVPVVWTLTNLIHN
MIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQSISNLNENQASEEEDELGELRELGY

--------------------------------------------------------------
>61712_61712_2_ORMDL3-PPP1R1B_ORMDL3_chr17_38080283_ENST00000304046_PPP1R1B_chr17_37785423_ENST00000579000_length(transcript)=1506nt_BP=314nt
GATTCGGCCGGAGCTGCCAGCGGGGAGGCTGCAGCCGCGGGTTGTTACAGCTGCTGGAGCAGCAGCGGCCCCCGCTCCCGGGAACCGTTC
CCGGGCCGTTGATCTTCGGCCCCACACGAACAGCAGAGAGGGGCAGCAGGATGAATGTGGGCACAGCGCACAGCGAGGTGAACCCCAACA
CGCGGGTGATGAACAGCCGTGGCATCTGGCTCTCCTACGTGCTGGCCATCGGTCTCCTCCACATCGTGCTGCTGAGCATCCCGTTTGTGA
GTGTCCCTGTCGTCTGGACCCTCACCAACCTCATTCACAACATGATCCGGCGCAGGAGACCAACGCCTGCCATGCTGTTCCGGCTCTCAG
AGCACTCCTCACCAGCTGTGCAGCGCATTGCTGAGTCTCACCTGCAGTCTATCAGCAATTTGAATGAGAACCAGGCCTCAGAGGAGGAGG
ATGAGCTGGGGGAGCTTCGGGAGCTGGGTTATCCAAGAGAGGAAGATGAGGAGGAAGAGGAGGATGATGAAGAAGAGGAAGAAGAAGAGG
ACAGCCAGGCTGAAGTCCTGAAGGTCATCAGGCAGTCTGCTGGGCAAAAGACAACCTGTGGCCAGGGTCTGGAAGGGCCCTGGGAGCGCC
CACCCCCTCTGGATGAGTCCGAGAGAGATGGAGGCTCTGAGGACCAAGTGGAAGACCCAGCACTAAGTGAGCCTGGGGAGGAACCTCAGC
GCCCTTCCCCCTCTGAGCCTGGCACATAGGCACCCAGCCTGCATCTCCCAGGAGGAAGTGGAGGGGACATCGCTGTTCCCCAGAAACCCA
CTCTATCCTCACCCTGTTTTGTGCTCTTCCCCTCGCCTGCTAGGGCTGCGGCTTCTGACTTCTAGAAGACTAAGGCTGGTCTGTGTTTGC
TTGTTTGCCCACCTTTGGCTGATACCCAGAGAACCTGGGCACTTGCTGCCTGATGCCCACCCCTGCCAGTCATTCCTCCATTCACCCAGC
GGGAGGTGGGATGTGAGACAGCCCACATTGGAAAATCCAGAAAACCGGGAACAGGGATTTGCCCTTCACAATTCTACTCCCCAGATCCTC
TCCCCTGGACACAGGAGACCCACAGGGCAGGACCCTAAGATCTGGGGAAAGGAGGTCCTGAGAACCTTGAGGTACCCTTAGATCCTTTTC
TACCCACTTTCCTATGGAGGATTCCAAGTCACCACTTCTCTCACCGGCTTCTACCAGGGTCCAGGACTAAGGCGTTTTTCTCCATAGCCT
CAACATTTTGGGAATCTTCCCTTAATCACCCTTGCTCCTCCTGGGTGCCTGGAAGATGGACTGGCAGAGACCTCTTTGTTGCGTTTTGTG
CTTTGATGCCAGGAATGCCGCCTAGTTTATGTCCCCGGTGGGGCACACAGCGGGGGGCGCCAGGTTTTCCTTGTCCCCCAGCTGCTCTGC

>61712_61712_2_ORMDL3-PPP1R1B_ORMDL3_chr17_38080283_ENST00000304046_PPP1R1B_chr17_37785423_ENST00000579000_length(amino acids)=235AA_BP=91
MLQLLEQQRPPLPGTVPGPLIFGPTRTAERGSRMNVGTAHSEVNPNTRVMNSRGIWLSYVLAIGLLHIVLLSIPFVSVPVVWTLTNLIHN
MIRRRRPTPAMLFRLSEHSSPAVQRIAESHLQSISNLNENQASEEEDELGELRELGYPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSA

--------------------------------------------------------------
>61712_61712_3_ORMDL3-PPP1R1B_ORMDL3_chr17_38080283_ENST00000304046_PPP1R1B_chr17_37785423_ENST00000580825_length(transcript)=983nt_BP=314nt
GATTCGGCCGGAGCTGCCAGCGGGGAGGCTGCAGCCGCGGGTTGTTACAGCTGCTGGAGCAGCAGCGGCCCCCGCTCCCGGGAACCGTTC
CCGGGCCGTTGATCTTCGGCCCCACACGAACAGCAGAGAGGGGCAGCAGGATGAATGTGGGCACAGCGCACAGCGAGGTGAACCCCAACA
CGCGGGTGATGAACAGCCGTGGCATCTGGCTCTCCTACGTGCTGGCCATCGGTCTCCTCCACATCGTGCTGCTGAGCATCCCGTTTGTGA
GTGTCCCTGTCGTCTGGACCCTCACCAACCTCATTCACAACATGATCCGGCGCAGGAGACCAACGCCTGCCATGCTGTTCCGGCTCTCAG
AGCACTCCTCACCAGAGGAGGAAGCCTCCCCCCACCAGAGAGCCTCAGGAGAGGGGCACCATCTCAAGTCGAAGAGACCCAACCCCTGTG
CCTACACACCACCTTCGCTGAAAGCTGTGCAGCGCATTGCTGAGTCTCACCTGCAGTCTATCAGCAATTTGAATGAGAACCAGGCCTCAG
AGGAGGAGGATGAGCTGGGGGAGCTTCGGGAGCTGGGTTATCCAAGAGAGGAAGATGAGGAGGAAGAGGAGGATGATGAAGAAGAGGAAG
AAGAAGAGGACAGCCAGGCTGAAGTCCTGAAGGTCATCAGGCAGTCTGCTGGGCAAAAGACAACCTGTGGCCAGGGTCTGGAAGGGCCCT
GGGAGCGCCCACCCCCTCTGGATGAGTCCGAGAGAGATGGAGGCTCTGAGGACCAAGTGGAAGACCCAGCACTAAGTGAGCCTGGGGAGG
AACCTCAGCGCCCTTCCCCCTCTGAGCCTGGCACATAGGCACCCAGCCTGCATCTCCCAGGAGGAAGTGGAGGGGACATCGCTGTTCCCC

>61712_61712_3_ORMDL3-PPP1R1B_ORMDL3_chr17_38080283_ENST00000304046_PPP1R1B_chr17_37785423_ENST00000580825_length(amino acids)=268AA_BP=91
MLQLLEQQRPPLPGTVPGPLIFGPTRTAERGSRMNVGTAHSEVNPNTRVMNSRGIWLSYVLAIGLLHIVLLSIPFVSVPVVWTLTNLIHN
MIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQSISNLNENQASEEEDELGELRELGY

--------------------------------------------------------------
>61712_61712_4_ORMDL3-PPP1R1B_ORMDL3_chr17_38080283_ENST00000394169_PPP1R1B_chr17_37785423_ENST00000254079_length(transcript)=2964nt_BP=1669nt
GTGCTCCTCTTCCAGAAGACAGGAGGTTTGCTGTTGTGAGGGCTGCTCTTTCCTGGGGGAGGGAATGGGAAGGGCTCACCTGGTGGCTGC
CCTGGTGGTGCTCAGCCTTGGCTTGAGTGTCTGGCATACTGGCTGGGCCCGGATATTTGTATGTGGAGCCAAGAGGGTGGGGCGGGAAGG
AGGGGGAAAGAGCTACCAGCAAAAAAGTGGTTAACACAACAGAGTTGCTGCAGGCTCTGGTTTGAGGCAGGTTATGAAACCACATCAGGG
CCCAGCACTAAGCAGCCACCTGCCAGCTATGGCAGCAGAAGTTTTCGGCTCAACTCCTGTAGACCTAGTCGACCTCTGCCAGCCTCTTCT
CTCTGTTTCTCCCCATCTAGGGTAGGGGCCAGTTGGTTGTTTTACTAATGGAAGTGATATGTATCCATAGTCACACGAAAGTCTCAAGAG
TGTTTCCTCATTGCCAGTCTTTTTGTTAGTTTATTGATCTCTTCTTTTTCAGGGGTCTCTGGTGGTTTCCTGCTCTCAGGGCACCTAGTG
TTTAGGCTTCAGGAAGAAGCTTCTGAGGGTGTTGGCTAGGACCTAGGTCTAGGCTTTTCCTAGGCTCATCAAGTTTTGTTGGCTGCCCTG
TGAAAGCCAGAAAGGCGTATGGGGTCCTGTGATCTGGGATTCCCCAAGGCTTTTGGCACTCCTGGACAAATACTAGGAAGGGTTAGTGGA
CTTTCTATACCAGCACCCCTGTAGGTGCGGGTTACAGAGAGGTGATGGGGTGGCAGTTTCAGGTCAGACTTGGGAAGCTCTTTCCCTCTC
CTTAGTCAGAGTTAAGTCCTTCAGAGCCCTCACTTGTCAGCCACATGCCGCCCTCCCCTCTCAGGTGGAGGCTTTTGCGTAGCAGCTGTC
CCAGGGGCTGCTAGAGTAACTGAAGCCCCAAGGCCCTGGGAAGATAAACAATCTGAGCCAGCTCTGGCTTTCTAGATACTTGAATTTCTG
TTAGGCTCAATTATCCAGCCTAGTGGGCTGCGCTGATGGGTCCCAGGAGCATCTCTTCAATCAGAATGCGCCCCAGGCTGGCGCACGGGT
GTTTGCTTGTTGGGATGGCGTGTTGTGGGTCACATTTTCTCTGAGGTCTCTAAGCTTGGAGCTGTCTGAGAAGAGGAAACTTGCTCCTGT
TATCCTGGAAGTAAATAACTGGCCCCTGAGGACTCAGTCTCCTGTGCAGGGCCCTCAGGGATCTGGGGACAGCCAAACTCTGGATAAGGG
GCAGATCATTCCACCCCTTCCTTCTCTACTTCCCTCTGCTCACTGTGGGTTGCGGCCACCTCCTGGTTCCTCCTGCTGCAGGACTCCTAC
CGTTGGTGCTGGGCAGGGGAAGGCATGGTGCTAATATACACCTGGAAACAGGTGCTGAGAGGGGAGACTGAGTCCTCCTAAGTTGGGGTT
TGGGGAGATCCAGAATTGAAAAAATCAGAGGAGAACAGCAGAGAGGGGCAGCAGGATGAATGTGGGCACAGCGCACAGCGAGGTGAACCC
CAACACGCGGGTGATGAACAGCCGTGGCATCTGGCTCTCCTACGTGCTGGCCATCGGTCTCCTCCACATCGTGCTGCTGAGCATCCCGTT
TGTGAGTGTCCCTGTCGTCTGGACCCTCACCAACCTCATTCACAACATGATCCGGCGCAGGAGACCAACGCCTGCCATGCTGTTCCGGCT
CTCAGAGCACTCCTCACCAGAGGAGGAAGCCTCCCCCCACCAGAGAGCCTCAGGAGAGGGGCACCATCTCAAGTCGAAGAGACCCAACCC
CTGTGCCTACACACCACCTTCGCTGAAAGCTGTGCAGCGCATTGCTGAGTCTCACCTGCAGTCTATCAGCAATTTGAATGAGAACCAGGC
CTCAGAGGAGGAGGATGAGCTGGGGGAGCTTCGGGAGCTGGGTTATCCAAGAGAGGAAGATGAGGAGGAAGAGGAGGATGATGAAGAAGA
GGAAGAAGAAGAGGACAGCCAGGCTGAAGTCCTGAAGGTCATCAGGCAGTCTGCTGGGCAAAAGACAACCTGTGGCCAGGGTCTGGAAGG
GCCCTGGGAGCGCCCACCCCCTCTGGATGAGTCCGAGAGAGATGGAGGCTCTGAGGACCAAGTGGAAGACCCAGCACTAAGTGAGCCTGG
GGAGGAACCTCAGCGCCCTTCCCCCTCTGAGCCTGGCACATAGGCACCCAGCCTGCATCTCCCAGGAGGAAGTGGAGGGGACATCGCTGT
TCCCCAGAAACCCACTCTATCCTCACCCTGTTTTGTGCTCTTCCCCTCGCCTGCTAGGGCTGCGGCTTCTGACTTCTAGAAGACTAAGGC
TGGTCTGTGTTTGCTTGTTTGCCCACCTTTGGCTGATACCCAGAGAACCTGGGCACTTGCTGCCTGATGCCCACCCCTGCCAGTCATTCC
TCCATTCACCCAGCGGGAGGTGGGATGTGAGACAGCCCACATTGGAAAATCCAGAAAACCGGGAACAGGGATTTGCCCTTCACAATTCTA
CTCCCCAGATCCTCTCCCCTGGACACAGGAGACCCACAGGGCAGGACCCTAAGATCTGGGGAAAGGAGGTCCTGAGAACCTTGAGGTACC
CTTAGATCCTTTTCTACCCACTTTCCTATGGAGGATTCCAAGTCACCACTTCTCTCACCGGCTTCTACCAGGGTCCAGGACTAAGGCGTT
TTTCTCCATAGCCTCAACATTTTGGGAATCTTCCCTTAATCACCCTTGCTCCTCCTGGGTGCCTGGAAGATGGACTGGCAGAGACCTCTT
TGTTGCGTTTTGTGCTTTGATGCCAGGAATGCCGCCTAGTTTATGTCCCCGGTGGGGCACACAGCGGGGGGCGCCAGGTTTTCCTTGTCC

>61712_61712_4_ORMDL3-PPP1R1B_ORMDL3_chr17_38080283_ENST00000394169_PPP1R1B_chr17_37785423_ENST00000254079_length(amino acids)=235AA_BP=58
MNVGTAHSEVNPNTRVMNSRGIWLSYVLAIGLLHIVLLSIPFVSVPVVWTLTNLIHNMIRRRRPTPAMLFRLSEHSSPEEEASPHQRASG
EGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQSISNLNENQASEEEDELGELRELGYPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSA

--------------------------------------------------------------
>61712_61712_5_ORMDL3-PPP1R1B_ORMDL3_chr17_38080283_ENST00000394169_PPP1R1B_chr17_37785423_ENST00000579000_length(transcript)=2861nt_BP=1669nt
GTGCTCCTCTTCCAGAAGACAGGAGGTTTGCTGTTGTGAGGGCTGCTCTTTCCTGGGGGAGGGAATGGGAAGGGCTCACCTGGTGGCTGC
CCTGGTGGTGCTCAGCCTTGGCTTGAGTGTCTGGCATACTGGCTGGGCCCGGATATTTGTATGTGGAGCCAAGAGGGTGGGGCGGGAAGG
AGGGGGAAAGAGCTACCAGCAAAAAAGTGGTTAACACAACAGAGTTGCTGCAGGCTCTGGTTTGAGGCAGGTTATGAAACCACATCAGGG
CCCAGCACTAAGCAGCCACCTGCCAGCTATGGCAGCAGAAGTTTTCGGCTCAACTCCTGTAGACCTAGTCGACCTCTGCCAGCCTCTTCT
CTCTGTTTCTCCCCATCTAGGGTAGGGGCCAGTTGGTTGTTTTACTAATGGAAGTGATATGTATCCATAGTCACACGAAAGTCTCAAGAG
TGTTTCCTCATTGCCAGTCTTTTTGTTAGTTTATTGATCTCTTCTTTTTCAGGGGTCTCTGGTGGTTTCCTGCTCTCAGGGCACCTAGTG
TTTAGGCTTCAGGAAGAAGCTTCTGAGGGTGTTGGCTAGGACCTAGGTCTAGGCTTTTCCTAGGCTCATCAAGTTTTGTTGGCTGCCCTG
TGAAAGCCAGAAAGGCGTATGGGGTCCTGTGATCTGGGATTCCCCAAGGCTTTTGGCACTCCTGGACAAATACTAGGAAGGGTTAGTGGA
CTTTCTATACCAGCACCCCTGTAGGTGCGGGTTACAGAGAGGTGATGGGGTGGCAGTTTCAGGTCAGACTTGGGAAGCTCTTTCCCTCTC
CTTAGTCAGAGTTAAGTCCTTCAGAGCCCTCACTTGTCAGCCACATGCCGCCCTCCCCTCTCAGGTGGAGGCTTTTGCGTAGCAGCTGTC
CCAGGGGCTGCTAGAGTAACTGAAGCCCCAAGGCCCTGGGAAGATAAACAATCTGAGCCAGCTCTGGCTTTCTAGATACTTGAATTTCTG
TTAGGCTCAATTATCCAGCCTAGTGGGCTGCGCTGATGGGTCCCAGGAGCATCTCTTCAATCAGAATGCGCCCCAGGCTGGCGCACGGGT
GTTTGCTTGTTGGGATGGCGTGTTGTGGGTCACATTTTCTCTGAGGTCTCTAAGCTTGGAGCTGTCTGAGAAGAGGAAACTTGCTCCTGT
TATCCTGGAAGTAAATAACTGGCCCCTGAGGACTCAGTCTCCTGTGCAGGGCCCTCAGGGATCTGGGGACAGCCAAACTCTGGATAAGGG
GCAGATCATTCCACCCCTTCCTTCTCTACTTCCCTCTGCTCACTGTGGGTTGCGGCCACCTCCTGGTTCCTCCTGCTGCAGGACTCCTAC
CGTTGGTGCTGGGCAGGGGAAGGCATGGTGCTAATATACACCTGGAAACAGGTGCTGAGAGGGGAGACTGAGTCCTCCTAAGTTGGGGTT
TGGGGAGATCCAGAATTGAAAAAATCAGAGGAGAACAGCAGAGAGGGGCAGCAGGATGAATGTGGGCACAGCGCACAGCGAGGTGAACCC
CAACACGCGGGTGATGAACAGCCGTGGCATCTGGCTCTCCTACGTGCTGGCCATCGGTCTCCTCCACATCGTGCTGCTGAGCATCCCGTT
TGTGAGTGTCCCTGTCGTCTGGACCCTCACCAACCTCATTCACAACATGATCCGGCGCAGGAGACCAACGCCTGCCATGCTGTTCCGGCT
CTCAGAGCACTCCTCACCAGCTGTGCAGCGCATTGCTGAGTCTCACCTGCAGTCTATCAGCAATTTGAATGAGAACCAGGCCTCAGAGGA
GGAGGATGAGCTGGGGGAGCTTCGGGAGCTGGGTTATCCAAGAGAGGAAGATGAGGAGGAAGAGGAGGATGATGAAGAAGAGGAAGAAGA
AGAGGACAGCCAGGCTGAAGTCCTGAAGGTCATCAGGCAGTCTGCTGGGCAAAAGACAACCTGTGGCCAGGGTCTGGAAGGGCCCTGGGA
GCGCCCACCCCCTCTGGATGAGTCCGAGAGAGATGGAGGCTCTGAGGACCAAGTGGAAGACCCAGCACTAAGTGAGCCTGGGGAGGAACC
TCAGCGCCCTTCCCCCTCTGAGCCTGGCACATAGGCACCCAGCCTGCATCTCCCAGGAGGAAGTGGAGGGGACATCGCTGTTCCCCAGAA
ACCCACTCTATCCTCACCCTGTTTTGTGCTCTTCCCCTCGCCTGCTAGGGCTGCGGCTTCTGACTTCTAGAAGACTAAGGCTGGTCTGTG
TTTGCTTGTTTGCCCACCTTTGGCTGATACCCAGAGAACCTGGGCACTTGCTGCCTGATGCCCACCCCTGCCAGTCATTCCTCCATTCAC
CCAGCGGGAGGTGGGATGTGAGACAGCCCACATTGGAAAATCCAGAAAACCGGGAACAGGGATTTGCCCTTCACAATTCTACTCCCCAGA
TCCTCTCCCCTGGACACAGGAGACCCACAGGGCAGGACCCTAAGATCTGGGGAAAGGAGGTCCTGAGAACCTTGAGGTACCCTTAGATCC
TTTTCTACCCACTTTCCTATGGAGGATTCCAAGTCACCACTTCTCTCACCGGCTTCTACCAGGGTCCAGGACTAAGGCGTTTTTCTCCAT
AGCCTCAACATTTTGGGAATCTTCCCTTAATCACCCTTGCTCCTCCTGGGTGCCTGGAAGATGGACTGGCAGAGACCTCTTTGTTGCGTT
TTGTGCTTTGATGCCAGGAATGCCGCCTAGTTTATGTCCCCGGTGGGGCACACAGCGGGGGGCGCCAGGTTTTCCTTGTCCCCCAGCTGC

>61712_61712_5_ORMDL3-PPP1R1B_ORMDL3_chr17_38080283_ENST00000394169_PPP1R1B_chr17_37785423_ENST00000579000_length(amino acids)=202AA_BP=58
MNVGTAHSEVNPNTRVMNSRGIWLSYVLAIGLLHIVLLSIPFVSVPVVWTLTNLIHNMIRRRRPTPAMLFRLSEHSSPAVQRIAESHLQS
ISNLNENQASEEEDELGELRELGYPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSAGQKTTCGQGLEGPWERPPPLDESERDGGSEDQV

--------------------------------------------------------------
>61712_61712_6_ORMDL3-PPP1R1B_ORMDL3_chr17_38080283_ENST00000394169_PPP1R1B_chr17_37785423_ENST00000580825_length(transcript)=2338nt_BP=1669nt
GTGCTCCTCTTCCAGAAGACAGGAGGTTTGCTGTTGTGAGGGCTGCTCTTTCCTGGGGGAGGGAATGGGAAGGGCTCACCTGGTGGCTGC
CCTGGTGGTGCTCAGCCTTGGCTTGAGTGTCTGGCATACTGGCTGGGCCCGGATATTTGTATGTGGAGCCAAGAGGGTGGGGCGGGAAGG
AGGGGGAAAGAGCTACCAGCAAAAAAGTGGTTAACACAACAGAGTTGCTGCAGGCTCTGGTTTGAGGCAGGTTATGAAACCACATCAGGG
CCCAGCACTAAGCAGCCACCTGCCAGCTATGGCAGCAGAAGTTTTCGGCTCAACTCCTGTAGACCTAGTCGACCTCTGCCAGCCTCTTCT
CTCTGTTTCTCCCCATCTAGGGTAGGGGCCAGTTGGTTGTTTTACTAATGGAAGTGATATGTATCCATAGTCACACGAAAGTCTCAAGAG
TGTTTCCTCATTGCCAGTCTTTTTGTTAGTTTATTGATCTCTTCTTTTTCAGGGGTCTCTGGTGGTTTCCTGCTCTCAGGGCACCTAGTG
TTTAGGCTTCAGGAAGAAGCTTCTGAGGGTGTTGGCTAGGACCTAGGTCTAGGCTTTTCCTAGGCTCATCAAGTTTTGTTGGCTGCCCTG
TGAAAGCCAGAAAGGCGTATGGGGTCCTGTGATCTGGGATTCCCCAAGGCTTTTGGCACTCCTGGACAAATACTAGGAAGGGTTAGTGGA
CTTTCTATACCAGCACCCCTGTAGGTGCGGGTTACAGAGAGGTGATGGGGTGGCAGTTTCAGGTCAGACTTGGGAAGCTCTTTCCCTCTC
CTTAGTCAGAGTTAAGTCCTTCAGAGCCCTCACTTGTCAGCCACATGCCGCCCTCCCCTCTCAGGTGGAGGCTTTTGCGTAGCAGCTGTC
CCAGGGGCTGCTAGAGTAACTGAAGCCCCAAGGCCCTGGGAAGATAAACAATCTGAGCCAGCTCTGGCTTTCTAGATACTTGAATTTCTG
TTAGGCTCAATTATCCAGCCTAGTGGGCTGCGCTGATGGGTCCCAGGAGCATCTCTTCAATCAGAATGCGCCCCAGGCTGGCGCACGGGT
GTTTGCTTGTTGGGATGGCGTGTTGTGGGTCACATTTTCTCTGAGGTCTCTAAGCTTGGAGCTGTCTGAGAAGAGGAAACTTGCTCCTGT
TATCCTGGAAGTAAATAACTGGCCCCTGAGGACTCAGTCTCCTGTGCAGGGCCCTCAGGGATCTGGGGACAGCCAAACTCTGGATAAGGG
GCAGATCATTCCACCCCTTCCTTCTCTACTTCCCTCTGCTCACTGTGGGTTGCGGCCACCTCCTGGTTCCTCCTGCTGCAGGACTCCTAC
CGTTGGTGCTGGGCAGGGGAAGGCATGGTGCTAATATACACCTGGAAACAGGTGCTGAGAGGGGAGACTGAGTCCTCCTAAGTTGGGGTT
TGGGGAGATCCAGAATTGAAAAAATCAGAGGAGAACAGCAGAGAGGGGCAGCAGGATGAATGTGGGCACAGCGCACAGCGAGGTGAACCC
CAACACGCGGGTGATGAACAGCCGTGGCATCTGGCTCTCCTACGTGCTGGCCATCGGTCTCCTCCACATCGTGCTGCTGAGCATCCCGTT
TGTGAGTGTCCCTGTCGTCTGGACCCTCACCAACCTCATTCACAACATGATCCGGCGCAGGAGACCAACGCCTGCCATGCTGTTCCGGCT
CTCAGAGCACTCCTCACCAGAGGAGGAAGCCTCCCCCCACCAGAGAGCCTCAGGAGAGGGGCACCATCTCAAGTCGAAGAGACCCAACCC
CTGTGCCTACACACCACCTTCGCTGAAAGCTGTGCAGCGCATTGCTGAGTCTCACCTGCAGTCTATCAGCAATTTGAATGAGAACCAGGC
CTCAGAGGAGGAGGATGAGCTGGGGGAGCTTCGGGAGCTGGGTTATCCAAGAGAGGAAGATGAGGAGGAAGAGGAGGATGATGAAGAAGA
GGAAGAAGAAGAGGACAGCCAGGCTGAAGTCCTGAAGGTCATCAGGCAGTCTGCTGGGCAAAAGACAACCTGTGGCCAGGGTCTGGAAGG
GCCCTGGGAGCGCCCACCCCCTCTGGATGAGTCCGAGAGAGATGGAGGCTCTGAGGACCAAGTGGAAGACCCAGCACTAAGTGAGCCTGG
GGAGGAACCTCAGCGCCCTTCCCCCTCTGAGCCTGGCACATAGGCACCCAGCCTGCATCTCCCAGGAGGAAGTGGAGGGGACATCGCTGT

>61712_61712_6_ORMDL3-PPP1R1B_ORMDL3_chr17_38080283_ENST00000394169_PPP1R1B_chr17_37785423_ENST00000580825_length(amino acids)=235AA_BP=58
MNVGTAHSEVNPNTRVMNSRGIWLSYVLAIGLLHIVLLSIPFVSVPVVWTLTNLIHNMIRRRRPTPAMLFRLSEHSSPEEEASPHQRASG
EGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQSISNLNENQASEEEDELGELRELGYPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ORMDL3-PPP1R1B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ORMDL3-PPP1R1B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ORMDL3-PPP1R1B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source